{"day":"29","page":"771 - 774","publisher":"American Association for the Advancement of Science","year":"2005","status":"public","date_published":"2005-07-29T00:00:00Z","acknowledgement":"This work was funded by the Medical Research Council.","date_created":"2018-12-11T11:54:56Z","month":"07","citation":{"ama":"Hinchliffe P, Sazanov LA. Biochemistry: Organization of iron-sulfur clusters in respiratory complex I. <i>Science</i>. 2005;309(5735):771-774. doi:<a href=\"https://doi.org/10.1126/science.1113988\">10.1126/science.1113988</a>","mla":"Hinchliffe, Philip, and Leonid A. Sazanov. “Biochemistry: Organization of Iron-Sulfur Clusters in Respiratory Complex I.” <i>Science</i>, vol. 309, no. 5735, American Association for the Advancement of Science, 2005, pp. 771–74, doi:<a href=\"https://doi.org/10.1126/science.1113988\">10.1126/science.1113988</a>.","short":"P. Hinchliffe, L.A. Sazanov, Science 309 (2005) 771–774.","ieee":"P. Hinchliffe and L. A. Sazanov, “Biochemistry: Organization of iron-sulfur clusters in respiratory complex I,” <i>Science</i>, vol. 309, no. 5735. American Association for the Advancement of Science, pp. 771–774, 2005.","chicago":"Hinchliffe, Philip, and Leonid A Sazanov. “Biochemistry: Organization of Iron-Sulfur Clusters in Respiratory Complex I.” <i>Science</i>. American Association for the Advancement of Science, 2005. <a href=\"https://doi.org/10.1126/science.1113988\">https://doi.org/10.1126/science.1113988</a>.","ista":"Hinchliffe P, Sazanov LA. 2005. Biochemistry: Organization of iron-sulfur clusters in respiratory complex I. Science. 309(5735), 771–774.","apa":"Hinchliffe, P., &#38; Sazanov, L. A. (2005). Biochemistry: Organization of iron-sulfur clusters in respiratory complex I. <i>Science</i>. American Association for the Advancement of Science. <a href=\"https://doi.org/10.1126/science.1113988\">https://doi.org/10.1126/science.1113988</a>"},"title":"Biochemistry: Organization of iron-sulfur clusters in respiratory complex I","quality_controlled":0,"doi":"10.1126/science.1113988","author":[{"last_name":"Hinchliffe","full_name":"Hinchliffe, Philip ","first_name":"Philip"},{"last_name":"Sazanov","id":"338D39FE-F248-11E8-B48F-1D18A9856A87","first_name":"Leonid A","full_name":"Leonid Sazanov","orcid":"0000-0002-0977-7989"}],"_id":"1962","abstract":[{"text":"\n\nComplex I of respiratory chains plays a central role in bioenergetics and is implicated in many human neurodegenerative diseases. An understanding of its mechanism requires a knowledge of the organization of redox centers. The arrangement of iron-sulfur clusters in the hydrophilic domain of complex I from Thermus thermophilus has been determined with the use of x-ray crystallography. One binuclear and six tetranuclear clusters are arranged, maximally 14 angstroms apart, in an 84-angstrom-long electron transfer chain. The binuclear cluster N1a and the tetranuclear cluster N7 are not in this pathway. Cluster N1a may play a role in the prevention of oxidative damage. The structure provides a framework for the interpretation of the large amounts of data accumulated on complex I.","lang":"eng"}],"issue":"5735","publication":"Science","publication_status":"published","type":"journal_article","extern":1,"volume":309,"date_updated":"2021-01-12T06:54:22Z","publist_id":"5122","intvolume":"       309"}