{"pmid":1,"day":"10","year":"1992","article_type":"original","publisher":"Izdatel'stvo Nauka","date_published":"1992-10-10T00:00:00Z","publist_id":"5138","language":[{"iso":"eng"}],"intvolume":"        57","title":"Effect of superlow doses (10(-18)-10-(-14) M) of biologically active substances: general rules, features, and possible mechanisms","quality_controlled":"1","main_file_link":[{"url":"https://europepmc.org/article/med/1457592"}],"oa_version":"None","issue":"10","article_processing_charge":"No","date_created":"2018-12-11T11:54:51Z","month":"10","citation":{"mla":"Sazanov, Leonid A., and Sergei Zaǐtsev. “Effect of Superlow Doses (10(-18)-10-(-14) M) of Biologically Active Substances: General Rules, Features, and Possible Mechanisms.” <i>Biochemistry (Moscow)</i>, vol. 57, no. 10, Izdatel’stvo Nauka, 1992, pp. 1443–60.","ama":"Sazanov LA, Zaǐtsev S. Effect of superlow doses (10(-18)-10-(-14) M) of biologically active substances: general rules, features, and possible mechanisms. <i>Biochemistry (Moscow)</i>. 1992;57(10):1443-1460.","short":"L.A. Sazanov, S. Zaǐtsev, Biochemistry (Moscow) 57 (1992) 1443–1460.","ieee":"L. A. Sazanov and S. Zaǐtsev, “Effect of superlow doses (10(-18)-10-(-14) M) of biologically active substances: general rules, features, and possible mechanisms,” <i>Biochemistry (Moscow)</i>, vol. 57, no. 10. Izdatel’stvo Nauka, pp. 1443–1460, 1992.","chicago":"Sazanov, Leonid A, and Sergei Zaǐtsev. “Effect of Superlow Doses (10(-18)-10-(-14) M) of Biologically Active Substances: General Rules, Features, and Possible Mechanisms.” <i>Biochemistry (Moscow)</i>. Izdatel’stvo Nauka, 1992.","ista":"Sazanov LA, Zaǐtsev S. 1992. Effect of superlow doses (10(-18)-10-(-14) M) of biologically active substances: general rules, features, and possible mechanisms. Biochemistry (Moscow). 57(10), 1443–1460.","apa":"Sazanov, L. A., &#38; Zaǐtsev, S. (1992). Effect of superlow doses (10(-18)-10-(-14) M) of biologically active substances: general rules, features, and possible mechanisms. <i>Biochemistry (Moscow)</i>. Izdatel’stvo Nauka."},"external_id":{"pmid":["1457592 "]},"page":"1443 - 1460","status":"public","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","type":"journal_article","extern":"1","volume":57,"date_updated":"2022-03-21T10:47:19Z","publication_identifier":{"issn":["0006-2979"]},"author":[{"id":"338D39FE-F248-11E8-B48F-1D18A9856A87","last_name":"Sazanov","orcid":"0000-0002-0977-7989","first_name":"Leonid A","full_name":"Sazanov, Leonid A"},{"last_name":"Zaǐtsev","full_name":"Zaǐtsev, Sergei","first_name":"Sergei"}],"_id":"1945","abstract":[{"text":"The effects of ultra-low (10(-18)-10(-14) M) doses (ULD) of biologically active substances have been reviewed in terms of common regularities of ULD effects and peculiarities of action of various groups of compounds. The most common and at the same time paradoxical regularities of ULD action are bi- or polymodal patterns of dose dependence, absence or presence of an inverse effect at higher doses, and instability of ULD effect. Possible mechanisms of ULD action including the mechanism based on the adaptation theory are discussed.","lang":"eng"}],"publication_status":"published","publication":"Biochemistry (Moscow)"}