{"intvolume":"       124","language":[{"iso":"eng"}],"publist_id":"5211","date_updated":"2021-01-12T06:53:50Z","volume":124,"type":"journal_article","publication_status":"published","publication":"Blood","issue":"21","oa_version":"None","abstract":[{"lang":"eng","text":"Unbiased high-throughput massively parallel sequencing methods have transformed the process of discovery of novel putative driver gene mutations in cancer. In chronic lymphocytic leukemia (CLL), these methods have yielded several unexpected findings, including the driver genes SF3B1, NOTCH1 and POT1. Recent analysis, utilizing down-sampling of existing datasets, has shown that the discovery process of putative drivers is far from complete across cancer. In CLL, while driver gene mutations affecting >10% of patients were efficiently discovered with previously published CLL cohorts of up to 160 samples subjected to whole exome sequencing (WES), this sample size has only 0.78 power to detect drivers affecting 5% of patients, and only 0.12 power for drivers affecting 2% of patients. These calculations emphasize the need to apply unbiased WES to larger patient cohorts."}],"_id":"1884","main_file_link":[{"url":"http://www.bloodjournal.org/content/124/21/1952?sso-checked=true"}],"author":[{"last_name":"Landau","full_name":"Landau, Dan","first_name":"Dan"},{"full_name":"Stewart, Chip","first_name":"Chip","last_name":"Stewart"},{"id":"4A918E98-F248-11E8-B48F-1D18A9856A87","last_name":"Reiter","orcid":"0000-0002-0170-7353","first_name":"Johannes","full_name":"Reiter, Johannes"},{"last_name":"Lawrence","first_name":"Michael","full_name":"Lawrence, Michael"},{"last_name":"Sougnez","full_name":"Sougnez, Carrie","first_name":"Carrie"},{"full_name":"Brown, Jennifer","first_name":"Jennifer","last_name":"Brown"},{"last_name":"Lopez Guillermo","first_name":"Armando","full_name":"Lopez Guillermo, Armando"},{"last_name":"Gabriel","first_name":"Stacey","full_name":"Gabriel, Stacey"},{"first_name":"Eric","full_name":"Lander, Eric","last_name":"Lander"},{"full_name":"Neuberg, Donna","first_name":"Donna","last_name":"Neuberg"},{"last_name":"López Otín","first_name":"Carlos","full_name":"López Otín, Carlos"},{"full_name":"Campo, Elias","first_name":"Elias","last_name":"Campo"},{"first_name":"Gad","full_name":"Getz, Gad","last_name":"Getz"},{"first_name":"Catherine","full_name":"Wu, Catherine","last_name":"Wu"}],"title":"Novel putative driver gene mutations in chronic lymphocytic leukemia (CLL): results from a combined analysis of whole exome sequencing of 262 primary CLL aamples","citation":{"apa":"Landau, D., Stewart, C., Reiter, J., Lawrence, M., Sougnez, C., Brown, J., … Wu, C. (2014). Novel putative driver gene mutations in chronic lymphocytic leukemia (CLL): results from a combined analysis of whole exome sequencing of 262 primary CLL aamples. <i>Blood</i>. American Society of Hematology.","ista":"Landau D, Stewart C, Reiter J, Lawrence M, Sougnez C, Brown J, Lopez Guillermo A, Gabriel S, Lander E, Neuberg D, López Otín C, Campo E, Getz G, Wu C. 2014. Novel putative driver gene mutations in chronic lymphocytic leukemia (CLL): results from a combined analysis of whole exome sequencing of 262 primary CLL aamples. Blood. 124(21), 1952–1952.","chicago":"Landau, Dan, Chip Stewart, Johannes Reiter, Michael Lawrence, Carrie Sougnez, Jennifer Brown, Armando Lopez Guillermo, et al. “Novel Putative Driver Gene Mutations in Chronic Lymphocytic Leukemia (CLL): Results from a Combined Analysis of Whole Exome Sequencing of 262 Primary CLL Aamples.” <i>Blood</i>. American Society of Hematology, 2014.","ieee":"D. Landau <i>et al.</i>, “Novel putative driver gene mutations in chronic lymphocytic leukemia (CLL): results from a combined analysis of whole exome sequencing of 262 primary CLL aamples,” <i>Blood</i>, vol. 124, no. 21. American Society of Hematology, pp. 1952–1952, 2014.","short":"D. Landau, C. Stewart, J. Reiter, M. Lawrence, C. Sougnez, J. Brown, A. Lopez Guillermo, S. Gabriel, E. Lander, D. Neuberg, C. López Otín, E. Campo, G. Getz, C. Wu, Blood 124 (2014) 1952–1952.","mla":"Landau, Dan, et al. “Novel Putative Driver Gene Mutations in Chronic Lymphocytic Leukemia (CLL): Results from a Combined Analysis of Whole Exome Sequencing of 262 Primary CLL Aamples.” <i>Blood</i>, vol. 124, no. 21, American Society of Hematology, 2014, pp. 1952–1952.","ama":"Landau D, Stewart C, Reiter J, et al. Novel putative driver gene mutations in chronic lymphocytic leukemia (CLL): results from a combined analysis of whole exome sequencing of 262 primary CLL aamples. <i>Blood</i>. 2014;124(21):1952-1952."},"month":"12","date_created":"2018-12-11T11:54:32Z","department":[{"_id":"KrCh"}],"user_id":"4435EBFC-F248-11E8-B48F-1D18A9856A87","date_published":"2014-12-04T00:00:00Z","publisher":"American Society of Hematology","status":"public","year":"2014","page":"1952 - 1952","day":"04"}