{"tmp":{"short":"CC BY (4.0)","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","image":"/images/cc_by.png","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode"},"day":"23","year":"2015","publisher":"Public Library of Science","ec_funded":1,"date_published":"2015-03-23T00:00:00Z","scopus_import":1,"quality_controlled":"1","title":"Evolution of bow-tie architectures in biology","oa_version":"Published Version","issue":"3","publist_id":"5278","language":[{"iso":"eng"}],"file":[{"content_type":"application/pdf","file_size":1811647,"date_created":"2018-12-12T10:15:39Z","checksum":"b8aa66f450ff8de393014b87ec7d2efb","access_level":"open_access","relation":"main_file","file_name":"IST-2016-452-v1+1_journal.pcbi.1004055.pdf","creator":"system","file_id":"5161","date_updated":"2020-07-14T12:45:17Z"}],"intvolume":"        11","pubrep_id":"452","project":[{"_id":"25681D80-B435-11E9-9278-68D0E5697425","grant_number":"291734","call_identifier":"FP7","name":"International IST Postdoc Fellowship Programme"}],"status":"public","oa":1,"file_date_updated":"2020-07-14T12:45:17Z","user_id":"3E5EF7F0-F248-11E8-B48F-1D18A9856A87","ddc":["576"],"department":[{"_id":"GaTk"}],"article_processing_charge":"No","month":"03","date_created":"2018-12-11T11:54:14Z","citation":{"ama":"Friedlander T, Mayo A, Tlusty T, Alon U. Evolution of bow-tie architectures in biology. <i>PLoS Computational Biology</i>. 2015;11(3). doi:<a href=\"https://doi.org/10.1371/journal.pcbi.1004055\">10.1371/journal.pcbi.1004055</a>","mla":"Friedlander, Tamar, et al. “Evolution of Bow-Tie Architectures in Biology.” <i>PLoS Computational Biology</i>, vol. 11, no. 3, Public Library of Science, 2015, doi:<a href=\"https://doi.org/10.1371/journal.pcbi.1004055\">10.1371/journal.pcbi.1004055</a>.","short":"T. Friedlander, A. Mayo, T. Tlusty, U. Alon, PLoS Computational Biology 11 (2015).","ieee":"T. Friedlander, A. Mayo, T. Tlusty, and U. Alon, “Evolution of bow-tie architectures in biology,” <i>PLoS Computational Biology</i>, vol. 11, no. 3. Public Library of Science, 2015.","ista":"Friedlander T, Mayo A, Tlusty T, Alon U. 2015. Evolution of bow-tie architectures in biology. PLoS Computational Biology. 11(3).","chicago":"Friedlander, Tamar, Avraham Mayo, Tsvi Tlusty, and Uri Alon. “Evolution of Bow-Tie Architectures in Biology.” <i>PLoS Computational Biology</i>. Public Library of Science, 2015. <a href=\"https://doi.org/10.1371/journal.pcbi.1004055\">https://doi.org/10.1371/journal.pcbi.1004055</a>.","apa":"Friedlander, T., Mayo, A., Tlusty, T., &#38; Alon, U. (2015). Evolution of bow-tie architectures in biology. <i>PLoS Computational Biology</i>. Public Library of Science. <a href=\"https://doi.org/10.1371/journal.pcbi.1004055\">https://doi.org/10.1371/journal.pcbi.1004055</a>"},"related_material":{"record":[{"relation":"research_data","id":"9718","status":"public"},{"relation":"research_data","status":"public","id":"9773"}]},"_id":"1827","author":[{"first_name":"Tamar","full_name":"Friedlander, Tamar","id":"36A5845C-F248-11E8-B48F-1D18A9856A87","last_name":"Friedlander"},{"first_name":"Avraham","full_name":"Mayo, Avraham","last_name":"Mayo"},{"last_name":"Tlusty","full_name":"Tlusty, Tsvi","first_name":"Tsvi"},{"last_name":"Alon","first_name":"Uri","full_name":"Alon, Uri"}],"doi":"10.1371/journal.pcbi.1004055","abstract":[{"lang":"eng","text":"Bow-tie or hourglass structure is a common architectural feature found in many biological systems. A bow-tie in a multi-layered structure occurs when intermediate layers have much fewer components than the input and output layers. Examples include metabolism where a handful of building blocks mediate between multiple input nutrients and multiple output biomass components, and signaling networks where information from numerous receptor types passes through a small set of signaling pathways to regulate multiple output genes. Little is known, however, about how bow-tie architectures evolve. Here, we address the evolution of bow-tie architectures using simulations of multi-layered systems evolving to fulfill a given input-output goal. We find that bow-ties spontaneously evolve when the information in the evolutionary goal can be compressed. Mathematically speaking, bow-ties evolve when the rank of the input-output matrix describing the evolutionary goal is deficient. The maximal compression possible (the rank of the goal) determines the size of the narrowest part of the network—that is the bow-tie. A further requirement is that a process is active to reduce the number of links in the network, such as product-rule mutations, otherwise a non-bow-tie solution is found in the evolutionary simulations. This offers a mechanism to understand a common architectural principle of biological systems, and a way to quantitate the effective rank of the goals under which they evolved."}],"publication_status":"published","publication":"PLoS Computational Biology","type":"journal_article","has_accepted_license":"1","date_updated":"2023-02-23T14:07:51Z","volume":11}