{"title":"Local retinal circuits of melanopsin-containing ganglion cells identified by transsynaptic viral tracing","quality_controlled":0,"acknowledgement":"This study was supported by Office of Naval Research Multidisciplinary University Research Initiative [ONR MURI] and Naval International Cooperative Opportunities in Science and Technology Program [NICOP] grants, a Marie Curie Excellence Grant, a Human Frontier Science Program [HFSP] Young Investigator grant, and Friedrich Miescher Institute funds to B.R.","status":"public","publisher":"Cell Press","year":"2007","intvolume":"        17","volume":17,"publist_id":"5313","date_created":"2018-12-11T11:54:04Z","_id":"1797","abstract":[{"lang":"eng","text":"Intrinsically photosensitive melanopsin-containing retinal ganglion cells (ipRGCs) control important physiological processes, including the circadian rhythm, the pupillary reflex, and the suppression of locomotor behavior (reviewed in [1]). ipRGCs are also activated by classical photoreceptors, the rods and cones, through local retinal circuits [2, 3]. ipRGCs can be transsynaptically labeled through the pupillary-reflex circuit with the derivatives of the Bartha strain of the alphaherpesvirus pseudorabies virus(PRV) [4, 5] that express GFP [6-12]. Bartha-strain derivatives spread only in the retrograde direction [13]. There is evidence that infected cells function normally for a while during GFP expression [7]. Here we combine transsynaptic PRV labeling, two-photon laser microscopy, and electrophysiological techniques to trace the local circuit of different ipRGC subtypes in the mouse retina and record light-evoked activity from the transsynaptically labeled ganglion cells. First, we show that ipRGCs are connected by monostratified amacrine cells that provide strong inhibition from classical-photoreceptor-driven circuits. Second, we show evidence that dopaminergic interplexiform cells are synaptically connected to ipRGCs. The latter finding provides a circuitry link between light-dark adaptation and ipRGC function."}],"citation":{"ieee":"T. Viney <i>et al.</i>, “Local retinal circuits of melanopsin-containing ganglion cells identified by transsynaptic viral tracing,” <i>Current Biology</i>, vol. 17, no. 11. Cell Press, pp. 981–988, 2007.","mla":"Viney, Tim, et al. “Local Retinal Circuits of Melanopsin-Containing Ganglion Cells Identified by Transsynaptic Viral Tracing.” <i>Current Biology</i>, vol. 17, no. 11, Cell Press, 2007, pp. 981–88, doi:<a href=\"https://doi.org/10.1016/j.cub.2007.04.058\">10.1016/j.cub.2007.04.058</a>.","short":"T. Viney, K. Bálint, D. Hillier, S. Siegert, Z. Boldogköi, L. Enquist, M. Meister, C. Cepko, B. Roska, Current Biology 17 (2007) 981–988.","ista":"Viney T, Bálint K, Hillier D, Siegert S, Boldogköi Z, Enquist L, Meister M, Cepko C, Roska B. 2007. Local retinal circuits of melanopsin-containing ganglion cells identified by transsynaptic viral tracing. Current Biology. 17(11), 981–988.","apa":"Viney, T., Bálint, K., Hillier, D., Siegert, S., Boldogköi, Z., Enquist, L., … Roska, B. (2007). Local retinal circuits of melanopsin-containing ganglion cells identified by transsynaptic viral tracing. <i>Current Biology</i>. Cell Press. <a href=\"https://doi.org/10.1016/j.cub.2007.04.058\">https://doi.org/10.1016/j.cub.2007.04.058</a>","chicago":"Viney, Tim, Kamill Bálint, Dániel Hillier, Sandra Siegert, Zsolt Boldogköi, Lynn Enquist, Markus Meister, Constance Cepko, and Botond Roska. “Local Retinal Circuits of Melanopsin-Containing Ganglion Cells Identified by Transsynaptic Viral Tracing.” <i>Current Biology</i>. Cell Press, 2007. <a href=\"https://doi.org/10.1016/j.cub.2007.04.058\">https://doi.org/10.1016/j.cub.2007.04.058</a>.","ama":"Viney T, Bálint K, Hillier D, et al. Local retinal circuits of melanopsin-containing ganglion cells identified by transsynaptic viral tracing. <i>Current Biology</i>. 2007;17(11):981-988. doi:<a href=\"https://doi.org/10.1016/j.cub.2007.04.058\">10.1016/j.cub.2007.04.058</a>"},"extern":1,"publication_status":"published","date_published":"2007-06-05T00:00:00Z","issue":"11","month":"06","date_updated":"2021-01-12T06:53:15Z","type":"journal_article","doi":"10.1016/j.cub.2007.04.058","page":"981 - 988","author":[{"first_name":"Tim","last_name":"Viney","full_name":"Viney, Tim J"},{"last_name":"Bálint","first_name":"Kamill","full_name":"Bálint, Kamill"},{"full_name":"Hillier, Dániel","first_name":"Dániel","last_name":"Hillier"},{"last_name":"Siegert","first_name":"Sandra","full_name":"Sandra Siegert","id":"36ACD32E-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0001-8635-0877"},{"full_name":"Boldogköi, Zsolt S","last_name":"Boldogköi","first_name":"Zsolt"},{"full_name":"Enquist, Lynn W","last_name":"Enquist","first_name":"Lynn"},{"full_name":"Meister, Markus","first_name":"Markus","last_name":"Meister"},{"full_name":"Cepko, Constance L","first_name":"Constance","last_name":"Cepko"},{"full_name":"Roska, Botond M","first_name":"Botond","last_name":"Roska"}],"publication":"Current Biology","day":"05"}