{"publication_status":"published","issue":"6021","publication":"Science","abstract":[{"text":"Morphogens, such as Decapentaplegic (Dpp) in the fly imaginal discs, form graded concentration profiles that control patterning and growth of developing organs. In the imaginal discs, proliferative growth is homogeneous in space, posing the conundrum of how morphogen concentration gradients could control position-independent growth. To understand the mechanism of proliferation control by the Dpp gradient, we quantified Dpp concentration and signaling levels during wing disc growth. Both Dpp concentration and signaling gradients scale with tissue size during development. On average, cells divide when Dpp signaling levels have increased by 50%. Our observations are consistent with a growth control mechanism based on temporal changes of cellular morphogen signaling levels. For a scaling gradient, this mechanism generates position-independent growth rates.","lang":"eng"}],"_id":"1724","doi":"10.1126/science.1200037","author":[{"last_name":"Wartlick","first_name":"Ortrud","full_name":"Wartlick, Ortrud"},{"first_name":"Peer","full_name":"Mumcu, Peer","last_name":"Mumcu"},{"orcid":"0000-0003-4509-4998","full_name":"Anna Kicheva","first_name":"Anna","id":"3959A2A0-F248-11E8-B48F-1D18A9856A87","last_name":"Kicheva"},{"last_name":"Bittig","full_name":"Bittig, Thomas","first_name":"Thomas"},{"first_name":"Carole","full_name":"Seum, Carole","last_name":"Seum"},{"first_name":"Frank","full_name":"Jülicher, Frank","last_name":"Jülicher"},{"last_name":"González Gaitán","first_name":"Marcos","full_name":"González-Gaitán, Marcos A"}],"quality_controlled":0,"title":"Dynamics of Dpp signaling and proliferation control","intvolume":"       331","date_updated":"2021-01-12T06:52:46Z","publist_id":"5406","volume":331,"extern":1,"type":"journal_article","date_published":"2011-03-04T00:00:00Z","status":"public","year":"2011","publisher":"American Association for the Advancement of Science","page":"1154 - 1159","day":"04","citation":{"short":"O. Wartlick, P. Mumcu, A. Kicheva, T. Bittig, C. Seum, F. Jülicher, M. González Gaitán, Science 331 (2011) 1154–1159.","mla":"Wartlick, Ortrud, et al. “Dynamics of Dpp Signaling and Proliferation Control.” <i>Science</i>, vol. 331, no. 6021, American Association for the Advancement of Science, 2011, pp. 1154–59, doi:<a href=\"https://doi.org/10.1126/science.1200037\">10.1126/science.1200037</a>.","ama":"Wartlick O, Mumcu P, Kicheva A, et al. Dynamics of Dpp signaling and proliferation control. <i>Science</i>. 2011;331(6021):1154-1159. doi:<a href=\"https://doi.org/10.1126/science.1200037\">10.1126/science.1200037</a>","ieee":"O. Wartlick <i>et al.</i>, “Dynamics of Dpp signaling and proliferation control,” <i>Science</i>, vol. 331, no. 6021. American Association for the Advancement of Science, pp. 1154–1159, 2011.","chicago":"Wartlick, Ortrud, Peer Mumcu, Anna Kicheva, Thomas Bittig, Carole Seum, Frank Jülicher, and Marcos González Gaitán. “Dynamics of Dpp Signaling and Proliferation Control.” <i>Science</i>. American Association for the Advancement of Science, 2011. <a href=\"https://doi.org/10.1126/science.1200037\">https://doi.org/10.1126/science.1200037</a>.","ista":"Wartlick O, Mumcu P, Kicheva A, Bittig T, Seum C, Jülicher F, González Gaitán M. 2011. Dynamics of Dpp signaling and proliferation control. Science. 331(6021), 1154–1159.","apa":"Wartlick, O., Mumcu, P., Kicheva, A., Bittig, T., Seum, C., Jülicher, F., &#38; González Gaitán, M. (2011). Dynamics of Dpp signaling and proliferation control. <i>Science</i>. American Association for the Advancement of Science. <a href=\"https://doi.org/10.1126/science.1200037\">https://doi.org/10.1126/science.1200037</a>"},"month":"03","date_created":"2018-12-11T11:53:40Z","acknowledgement":"P.M., T.B., and F.J. were supported by the Max-Planck-Gesellschaft. O.W., A.K., C.S., and M.G.-G. were supported by Geneva University and by European Research Council advanced investigator grant (SARA), SystemsX (LipidX), Swiss National Science Foundation (SNF), National Centre of Competence in Research (NCCR) chemical biology and Frontiers in Genetics and R'equip grants"}