{"_id":"1723","author":[{"full_name":"Escudero, Luis M","first_name":"Luis","last_name":"Escudero"},{"last_name":"Costa","first_name":"Luciano","full_name":"Costa, Luciano"},{"first_name":"Anna","full_name":"Anna Kicheva","orcid":"0000-0003-4509-4998","last_name":"Kicheva","id":"3959A2A0-F248-11E8-B48F-1D18A9856A87"},{"last_name":"Briscoe","full_name":"Briscoe, James","first_name":"James"},{"last_name":"Freeman","full_name":"Freeman, Matthew","first_name":"Matthew"},{"last_name":"Babu","first_name":"Madan","full_name":"Babu, Madan M"}],"doi":"10.1038/ncomms1536","quality_controlled":0,"title":"Epithelial organisation revealed by a network of cellular contacts","publication_status":"published","issue":"1","publication":"Nature Communications","abstract":[{"lang":"eng","text":"The emergence of differences in the arrangement of cells is the first step towards the establishment of many organs. Understanding this process is limited by the lack of systematic characterization of epithelial organisation. Here we apply network theory at the scale of individual cells to uncover patterns in cell-to-cell contacts that govern epithelial organisation. We provide an objective characterisation of epithelia using network representation, where cells are nodes and cell contacts are links. The features of individual cells, together with attributes of the cellular network, produce a defining signature that distinguishes epithelia from different organs, species, developmental stages and genetic conditions. The approach permits characterization, quantification and classification of normal and perturbed epithelia, and establishes a framework for understanding molecular mechanisms that underpin the architecture of complex tissues."}],"date_updated":"2021-01-12T06:52:46Z","publist_id":"5405","volume":2,"extern":1,"type":"journal_article","intvolume":"         2","status":"public","publisher":"Nature Publishing Group","year":"2011","day":"01","date_published":"2011-01-01T00:00:00Z","acknowledgement":"We acknowledge the MRC for funding, M.M.B. acknowledges Darwin College, EMBO YIP and Schlumberger Ltd for support. L.M.E. is funded by the Marie Curie and the EMBO fellowships. L.d.F.C. is grateful to FAPESP (05/00587-5) and CNPq (301303/06-1) for financial support. Part of this work was performed during a Visiting Scholarship to L.d.F.C. from St Catharine's College, University of Cambridge. J.B. is supported by the MRC (UK) and A.K. by a FEBS fellowship","citation":{"ista":"Escudero L, Costa L, Kicheva A, Briscoe J, Freeman M, Babu M. 2011. Epithelial organisation revealed by a network of cellular contacts. Nature Communications. 2(1).","chicago":"Escudero, Luis, Luciano Costa, Anna Kicheva, James Briscoe, Matthew Freeman, and Madan Babu. “Epithelial Organisation Revealed by a Network of Cellular Contacts.” <i>Nature Communications</i>. Nature Publishing Group, 2011. <a href=\"https://doi.org/10.1038/ncomms1536\">https://doi.org/10.1038/ncomms1536</a>.","apa":"Escudero, L., Costa, L., Kicheva, A., Briscoe, J., Freeman, M., &#38; Babu, M. (2011). Epithelial organisation revealed by a network of cellular contacts. <i>Nature Communications</i>. Nature Publishing Group. <a href=\"https://doi.org/10.1038/ncomms1536\">https://doi.org/10.1038/ncomms1536</a>","ama":"Escudero L, Costa L, Kicheva A, Briscoe J, Freeman M, Babu M. Epithelial organisation revealed by a network of cellular contacts. <i>Nature Communications</i>. 2011;2(1). doi:<a href=\"https://doi.org/10.1038/ncomms1536\">10.1038/ncomms1536</a>","mla":"Escudero, Luis, et al. “Epithelial Organisation Revealed by a Network of Cellular Contacts.” <i>Nature Communications</i>, vol. 2, no. 1, Nature Publishing Group, 2011, doi:<a href=\"https://doi.org/10.1038/ncomms1536\">10.1038/ncomms1536</a>.","short":"L. Escudero, L. Costa, A. Kicheva, J. Briscoe, M. Freeman, M. Babu, Nature Communications 2 (2011).","ieee":"L. Escudero, L. Costa, A. Kicheva, J. Briscoe, M. Freeman, and M. Babu, “Epithelial organisation revealed by a network of cellular contacts,” <i>Nature Communications</i>, vol. 2, no. 1. Nature Publishing Group, 2011."},"month":"01","date_created":"2018-12-11T11:53:40Z"}