{"acknowledgement":"EK is supported by an EMBO LTF, AK by a FEBS fellowship, and JB by MRC (UK) and the Wellcome Trust","citation":{"apa":"Kutějová, E., Briscoe, J., &#38; Kicheva, A. (2009). Temporal dynamics of patterning by morphogen gradients. <i>Current Opinion in Genetics &#38; Development</i>. Elsevier. <a href=\"https://doi.org/10.1016/j.gde.2009.05.004\">https://doi.org/10.1016/j.gde.2009.05.004</a>","ista":"Kutějová E, Briscoe J, Kicheva A. 2009. Temporal dynamics of patterning by morphogen gradients. Current Opinion in Genetics &#38; Development. 19(4), 315–322.","chicago":"Kutějová, Eva, James Briscoe, and Anna Kicheva. “Temporal Dynamics of Patterning by Morphogen Gradients.” <i>Current Opinion in Genetics &#38; Development</i>. Elsevier, 2009. <a href=\"https://doi.org/10.1016/j.gde.2009.05.004\">https://doi.org/10.1016/j.gde.2009.05.004</a>.","ieee":"E. Kutějová, J. Briscoe, and A. Kicheva, “Temporal dynamics of patterning by morphogen gradients,” <i>Current Opinion in Genetics &#38; Development</i>, vol. 19, no. 4. Elsevier, pp. 315–322, 2009.","short":"E. Kutějová, J. Briscoe, A. Kicheva, Current Opinion in Genetics &#38; Development 19 (2009) 315–322.","ama":"Kutějová E, Briscoe J, Kicheva A. Temporal dynamics of patterning by morphogen gradients. <i>Current Opinion in Genetics &#38; Development</i>. 2009;19(4):315-322. doi:<a href=\"https://doi.org/10.1016/j.gde.2009.05.004\">10.1016/j.gde.2009.05.004</a>","mla":"Kutějová, Eva, et al. “Temporal Dynamics of Patterning by Morphogen Gradients.” <i>Current Opinion in Genetics &#38; Development</i>, vol. 19, no. 4, Elsevier, 2009, pp. 315–22, doi:<a href=\"https://doi.org/10.1016/j.gde.2009.05.004\">10.1016/j.gde.2009.05.004</a>."},"date_created":"2018-12-11T11:53:38Z","month":"08","page":"315 - 322","status":"public","publisher":"Elsevier","year":"2009","day":"01","date_published":"2009-08-01T00:00:00Z","volume":19,"publist_id":"5410","date_updated":"2021-01-12T06:52:44Z","type":"journal_article","extern":1,"intvolume":"        19","doi":"10.1016/j.gde.2009.05.004","author":[{"first_name":"Eva","full_name":"Kutějová, Eva","last_name":"Kutějová"},{"last_name":"Briscoe","full_name":"Briscoe, James","first_name":"James"},{"last_name":"Kicheva","id":"3959A2A0-F248-11E8-B48F-1D18A9856A87","full_name":"Anna Kicheva","first_name":"Anna","orcid":"0000-0003-4509-4998"}],"_id":"1718","title":"Temporal dynamics of patterning by morphogen gradients","quality_controlled":0,"issue":"4","publication":"Current Opinion in Genetics & Development","publication_status":"published","abstract":[{"text":"Morphogens act as graded positional cues to control cell fate specification in many developing tissues. This concept, in which a signaling gradient regulates differential gene expression in a concentration-dependent manner, has received considerable experimental support. Nevertheless, several recent studies have challenged the straightforward model of morphogen activity. In particular, the observation that pattern formation is a dynamic process has raised questions about the influence of time on morphogen activity. Here we propose that the spatiotemporal dynamics of the cellular response to a morphogen gradient depend on a combination of temporal alterations to the morphogen gradient itself, the dynamics of its signal transduction and downstream interactions between target genes.","lang":"eng"}]}