{"file_date_updated":"2020-07-14T12:45:03Z","isi":1,"ddc":["570"],"intvolume":"        14","publist_id":"7762","volume":14,"year":"2018","citation":{"short":"T. Fehrentz, F. Huber, N. Hartrampf, T. Bruegmann, J. Frank, N. Fine, D. Malan, J.G. Danzl, D. Tikhonov, M. Sumser, P. Sasse, D. Hodson, B. Zhorov, N. Klocker, D. Trauner, Nature Chemical Biology 14 (2018) 764–767.","apa":"Fehrentz, T., Huber, F., Hartrampf, N., Bruegmann, T., Frank, J., Fine, N., … Trauner, D. (2018). Optical control of L-type Ca2+ channels using a diltiazem photoswitch. <i>Nature Chemical Biology</i>. Nature Publishing Group. <a href=\"https://doi.org/10.1038/s41589-018-0090-8\">https://doi.org/10.1038/s41589-018-0090-8</a>","ista":"Fehrentz T, Huber F, Hartrampf N, Bruegmann T, Frank J, Fine N, Malan D, Danzl JG, Tikhonov D, Sumser M, Sasse P, Hodson D, Zhorov B, Klocker N, Trauner D. 2018. Optical control of L-type Ca2+ channels using a diltiazem photoswitch. Nature Chemical Biology. 14(8), 764–767.","chicago":"Fehrentz, Timm, Florian Huber, Nina Hartrampf, Tobias Bruegmann, James Frank, Nicholas Fine, Daniela Malan, et al. “Optical Control of L-Type Ca2+ Channels Using a Diltiazem Photoswitch.” <i>Nature Chemical Biology</i>. Nature Publishing Group, 2018. <a href=\"https://doi.org/10.1038/s41589-018-0090-8\">https://doi.org/10.1038/s41589-018-0090-8</a>.","ama":"Fehrentz T, Huber F, Hartrampf N, et al. Optical control of L-type Ca2+ channels using a diltiazem photoswitch. <i>Nature Chemical Biology</i>. 2018;14(8):764-767. doi:<a href=\"https://doi.org/10.1038/s41589-018-0090-8\">10.1038/s41589-018-0090-8</a>","ieee":"T. Fehrentz <i>et al.</i>, “Optical control of L-type Ca2+ channels using a diltiazem photoswitch,” <i>Nature Chemical Biology</i>, vol. 14, no. 8. Nature Publishing Group, pp. 764–767, 2018.","mla":"Fehrentz, Timm, et al. “Optical Control of L-Type Ca2+ Channels Using a Diltiazem Photoswitch.” <i>Nature Chemical Biology</i>, vol. 14, no. 8, Nature Publishing Group, 2018, pp. 764–67, doi:<a href=\"https://doi.org/10.1038/s41589-018-0090-8\">10.1038/s41589-018-0090-8</a>."},"article_type":"original","language":[{"iso":"eng"}],"_id":"159","page":"764 - 767","doi":"10.1038/s41589-018-0090-8","has_accepted_license":"1","author":[{"full_name":"Fehrentz, Timm","first_name":"Timm","last_name":"Fehrentz"},{"full_name":"Huber, Florian","last_name":"Huber","first_name":"Florian"},{"full_name":"Hartrampf, Nina","first_name":"Nina","last_name":"Hartrampf"},{"last_name":"Bruegmann","first_name":"Tobias","full_name":"Bruegmann, Tobias"},{"first_name":"James","last_name":"Frank","full_name":"Frank, James"},{"full_name":"Fine, Nicholas","last_name":"Fine","first_name":"Nicholas"},{"first_name":"Daniela","last_name":"Malan","full_name":"Malan, Daniela"},{"orcid":"0000-0001-8559-3973","id":"42EFD3B6-F248-11E8-B48F-1D18A9856A87","full_name":"Danzl, Johann G","first_name":"Johann G","last_name":"Danzl"},{"full_name":"Tikhonov, Denis","last_name":"Tikhonov","first_name":"Denis"},{"first_name":"Maritn","last_name":"Sumser","full_name":"Sumser, Maritn"},{"full_name":"Sasse, Philipp","last_name":"Sasse","first_name":"Philipp"},{"full_name":"Hodson, David","last_name":"Hodson","first_name":"David"},{"first_name":"Boris","last_name":"Zhorov","full_name":"Zhorov, Boris"},{"first_name":"Nikolaj","last_name":"Klocker","full_name":"Klocker, Nikolaj"},{"full_name":"Trauner, Dirk","first_name":"Dirk","last_name":"Trauner"}],"publication":"Nature Chemical Biology","external_id":{"isi":["000438970200010"]},"title":"Optical control of L-type Ca2+ channels using a diltiazem photoswitch","quality_controlled":"1","related_material":{"link":[{"url":"https://doi.org/10.1038/s41589-021-00744-3","relation":"erratum"}]},"status":"public","oa":1,"oa_version":"Submitted Version","date_created":"2018-12-11T11:44:56Z","user_id":"c635000d-4b10-11ee-a964-aac5a93f6ac1","publisher":"Nature Publishing Group","scopus_import":"1","date_published":"2018-07-16T00:00:00Z","publication_status":"published","issue":"8","department":[{"_id":"JoDa"}],"abstract":[{"text":"L-type Ca2+ channels (LTCCs) play a crucial role in excitation-contraction coupling and release of hormones from secretory cells. They are targets of antihypertensive and antiarrhythmic drugs such as diltiazem. Here, we present a photoswitchable diltiazem, FHU-779, which can be used to reversibly block endogenous LTCCs by light. FHU-779 is as potent as diltiazem and can be used to place pancreatic β-cell function and cardiac activity under optical control.","lang":"eng"}],"file":[{"date_updated":"2020-07-14T12:45:03Z","file_id":"7832","date_created":"2020-05-14T12:14:09Z","file_size":6321000,"checksum":"d42935094ec845f54a0688bf12986d62","relation":"main_file","content_type":"application/pdf","creator":"dernst","access_level":"open_access","file_name":"2018_NatureChemicalBiology_Fehrentz.pdf"}],"type":"journal_article","day":"16","month":"07","article_processing_charge":"No","date_updated":"2023-09-13T09:36:35Z"}