{"publisher":"National Academy of Sciences","scopus_import":"1","oa_version":"Published Version","oa":1,"date_created":"2023-08-13T22:01:12Z","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","title":"Nuclear spin effects in biological processes","quality_controlled":"1","status":"public","month":"07","article_processing_charge":"Yes (in subscription journal)","date_updated":"2023-10-17T11:45:25Z","pmid":1,"tmp":{"legal_code_url":"https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode","image":"/images/cc_by_nc_nd.png","name":"Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)","short":"CC BY-NC-ND (4.0)"},"type":"journal_article","file":[{"success":1,"file_id":"14047","file_size":1003092,"date_created":"2023-08-14T07:43:45Z","date_updated":"2023-08-14T07:43:45Z","content_type":"application/pdf","creator":"dernst","access_level":"open_access","file_name":"2023_PNAS_Vardi.pdf","checksum":"a5ed64788a5acef9b9a300a26fa5a177","relation":"main_file"}],"day":"31","department":[{"_id":"MiLe"}],"abstract":[{"lang":"eng","text":"Traditionally, nuclear spin is not considered to affect biological processes. Recently, this has changed as isotopic fractionation that deviates from classical mass dependence was reported both in vitro and in vivo. In these cases, the isotopic effect correlates with the nuclear magnetic spin. Here, we show nuclear spin effects using stable oxygen isotopes (16O, 17O, and 18O) in two separate setups: an artificial dioxygen production system and biological aquaporin channels in cells. We observe that oxygen dynamics in chiral environments (in particular its transport) depend on nuclear spin, suggesting future applications for controlled isotope separation to be used, for instance, in NMR. To demonstrate the mechanism behind our findings, we formulate theoretical models based on a nuclear-spin-enhanced switch between electronic spin states. Accounting for the role of nuclear spin in biology can provide insights into the role of quantum effects in living systems and help inspire the development of future biotechnology solutions."}],"date_published":"2023-07-31T00:00:00Z","publication_status":"published","issue":"32","year":"2023","intvolume":"       120","volume":120,"project":[{"_id":"2688CF98-B435-11E9-9278-68D0E5697425","name":"Angulon: physics and applications of a new quasiparticle","grant_number":"801770","call_identifier":"H2020"}],"ddc":["530"],"acknowledgement":"N.M.-S. acknowledges the support of the Ministry of Energy, Israel, as part of the scholarship program for graduate students in the fields of energy. M.L. acknowledges support by the European Research Council (ERC) Starting Grant No. 801770 (ANGULON). Y.P. acknowledges the support of the Ministry of Innovation, Science and Technology, Israel Grant No. 1001593872. Y.P acknowledges the support of the BSF-NSF 094 Grant No. 2022503.","file_date_updated":"2023-08-14T07:43:45Z","external_id":{"pmid":["37523549"]},"publication_identifier":{"eissn":["1091-6490"]},"has_accepted_license":"1","publication":"Proceedings of the National Academy of Sciences of the United States of America","author":[{"last_name":"Vardi","first_name":"Ofek","full_name":"Vardi, Ofek"},{"full_name":"Maroudas-Sklare, Naama","first_name":"Naama","last_name":"Maroudas-Sklare"},{"full_name":"Kolodny, Yuval","last_name":"Kolodny","first_name":"Yuval"},{"orcid":"0000-0003-0393-5525","full_name":"Volosniev, Artem","id":"37D278BC-F248-11E8-B48F-1D18A9856A87","last_name":"Volosniev","first_name":"Artem"},{"full_name":"Saragovi, Amijai","first_name":"Amijai","last_name":"Saragovi"},{"first_name":"Nir","last_name":"Galili","full_name":"Galili, Nir"},{"last_name":"Ferrera","first_name":"Stav","full_name":"Ferrera, Stav"},{"orcid":"0000-0001-9666-3543","full_name":"Ghazaryan, Areg","id":"4AF46FD6-F248-11E8-B48F-1D18A9856A87","last_name":"Ghazaryan","first_name":"Areg"},{"full_name":"Yuran, Nir","last_name":"Yuran","first_name":"Nir"},{"last_name":"Affek","first_name":"Hagit P.","full_name":"Affek, Hagit P."},{"first_name":"Boaz","last_name":"Luz","full_name":"Luz, Boaz"},{"full_name":"Goldsmith, Yonaton","last_name":"Goldsmith","first_name":"Yonaton"},{"first_name":"Nir","last_name":"Keren","full_name":"Keren, Nir"},{"first_name":"Shira","last_name":"Yochelis","full_name":"Yochelis, Shira"},{"full_name":"Halevy, Itay","first_name":"Itay","last_name":"Halevy"},{"last_name":"Lemeshko","first_name":"Mikhail","full_name":"Lemeshko, Mikhail","id":"37CB05FA-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-6990-7802"},{"full_name":"Paltiel, Yossi","last_name":"Paltiel","first_name":"Yossi"}],"doi":"10.1073/pnas.2300828120","_id":"14037","article_number":"e2300828120","language":[{"iso":"eng"}],"citation":{"ista":"Vardi O, Maroudas-Sklare N, Kolodny Y, Volosniev A, Saragovi A, Galili N, Ferrera S, Ghazaryan A, Yuran N, Affek HP, Luz B, Goldsmith Y, Keren N, Yochelis S, Halevy I, Lemeshko M, Paltiel Y. 2023. Nuclear spin effects in biological processes. Proceedings of the National Academy of Sciences of the United States of America. 120(32), e2300828120.","chicago":"Vardi, Ofek, Naama Maroudas-Sklare, Yuval Kolodny, Artem Volosniev, Amijai Saragovi, Nir Galili, Stav Ferrera, et al. “Nuclear Spin Effects in Biological Processes.” <i>Proceedings of the National Academy of Sciences of the United States of America</i>. National Academy of Sciences, 2023. <a href=\"https://doi.org/10.1073/pnas.2300828120\">https://doi.org/10.1073/pnas.2300828120</a>.","apa":"Vardi, O., Maroudas-Sklare, N., Kolodny, Y., Volosniev, A., Saragovi, A., Galili, N., … Paltiel, Y. (2023). Nuclear spin effects in biological processes. <i>Proceedings of the National Academy of Sciences of the United States of America</i>. National Academy of Sciences. <a href=\"https://doi.org/10.1073/pnas.2300828120\">https://doi.org/10.1073/pnas.2300828120</a>","ama":"Vardi O, Maroudas-Sklare N, Kolodny Y, et al. Nuclear spin effects in biological processes. <i>Proceedings of the National Academy of Sciences of the United States of America</i>. 2023;120(32). doi:<a href=\"https://doi.org/10.1073/pnas.2300828120\">10.1073/pnas.2300828120</a>","short":"O. Vardi, N. Maroudas-Sklare, Y. Kolodny, A. Volosniev, A. Saragovi, N. Galili, S. Ferrera, A. Ghazaryan, N. Yuran, H.P. Affek, B. Luz, Y. Goldsmith, N. Keren, S. Yochelis, I. Halevy, M. Lemeshko, Y. Paltiel, Proceedings of the National Academy of Sciences of the United States of America 120 (2023).","mla":"Vardi, Ofek, et al. “Nuclear Spin Effects in Biological Processes.” <i>Proceedings of the National Academy of Sciences of the United States of America</i>, vol. 120, no. 32, e2300828120, National Academy of Sciences, 2023, doi:<a href=\"https://doi.org/10.1073/pnas.2300828120\">10.1073/pnas.2300828120</a>.","ieee":"O. Vardi <i>et al.</i>, “Nuclear spin effects in biological processes,” <i>Proceedings of the National Academy of Sciences of the United States of America</i>, vol. 120, no. 32. National Academy of Sciences, 2023."},"article_type":"original","ec_funded":1}