{"doi":"10.3389/fphy.2023.1202132","publication":"Frontiers in Physics","acknowledged_ssus":[{"_id":"EM-Fac"}],"intvolume":"        11","article_type":"original","publication_identifier":{"eissn":["2296-424X"]},"language":[{"iso":"eng"}],"year":"2023","date_updated":"2023-12-13T12:04:10Z","day":"14","external_id":{"isi":["001038636400001"]},"oa":1,"has_accepted_license":"1","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","publisher":"Frontiers","abstract":[{"lang":"eng","text":"The use of multimodal readout mechanisms next to label-free real-time monitoring of biomolecular interactions can provide valuable insight into surface-based reaction mechanisms. To this end, the combination of an electrolyte-gated field-effect transistor (EG-FET) with a fiber optic-coupled surface plasmon resonance (FO-SPR) probe serving as gate electrode has been investigated to deconvolute surface mass and charge density variations associated to surface reactions. However, applying an electrochemical potential on such gold-coated FO-SPR gate electrodes can induce gradual morphological changes of the thin gold film, leading to an irreversible blue-shift of the SPR wavelength and a substantial signal drift. We show that mild annealing leads to optical and electronic signal stabilization (20-fold lower signal drift than as-sputtered fiber optic gates) and improved overall analytical performance characteristics. The thermal treatment prevents morphological changes of the thin gold-film occurring during operation, hence providing reliable and stable data immediately upon gate voltage application. Thus, the readout output of both transducing principles, the optical FO-SPR and electronic EG-FET, stays constant throughout the whole sensing time-window and the long-term effect of thermal treatment is also improved, providing stable signals even after 1 year of storage. Annealing should therefore be considered a necessary modification for applying fiber optic gate electrodes in real-time multimodal investigations of surface reactions at the solid-liquid interface."}],"isi":1,"oa_version":"Published Version","tmp":{"image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","short":"CC BY (4.0)"},"ddc":["530"],"article_processing_charge":"Yes","type":"journal_article","department":[{"_id":"MaIb"}],"volume":11,"quality_controlled":"1","publication_status":"published","_id":"13968","file":[{"creator":"dernst","success":1,"content_type":"application/pdf","checksum":"fb36dda665e57bab006a000bf0faacd5","access_level":"open_access","file_name":"2023_FrontiersPhysics_Hasler.pdf","file_id":"13978","date_created":"2023-08-07T07:48:11Z","relation":"main_file","file_size":2421758,"date_updated":"2023-08-07T07:48:11Z"}],"status":"public","citation":{"short":"R. Hasler, M.H. Steger-Polt, C. Reiner-Rozman, S. Fossati, S. Lee, P. Aspermair, C. Kleber, M. Ibáñez, J. Dostalek, W. Knoll, Frontiers in Physics 11 (2023).","apa":"Hasler, R., Steger-Polt, M. H., Reiner-Rozman, C., Fossati, S., Lee, S., Aspermair, P., … Knoll, W. (2023). Optical and electronic signal stabilization of plasmonic fiber optic gate electrodes: Towards improved real-time dual-mode biosensing. <i>Frontiers in Physics</i>. Frontiers. <a href=\"https://doi.org/10.3389/fphy.2023.1202132\">https://doi.org/10.3389/fphy.2023.1202132</a>","mla":"Hasler, Roger, et al. “Optical and Electronic Signal Stabilization of Plasmonic Fiber Optic Gate Electrodes: Towards Improved Real-Time Dual-Mode Biosensing.” <i>Frontiers in Physics</i>, vol. 11, 1202132, Frontiers, 2023, doi:<a href=\"https://doi.org/10.3389/fphy.2023.1202132\">10.3389/fphy.2023.1202132</a>.","ista":"Hasler R, Steger-Polt MH, Reiner-Rozman C, Fossati S, Lee S, Aspermair P, Kleber C, Ibáñez M, Dostalek J, Knoll W. 2023. Optical and electronic signal stabilization of plasmonic fiber optic gate electrodes: Towards improved real-time dual-mode biosensing. Frontiers in Physics. 11, 1202132.","ieee":"R. Hasler <i>et al.</i>, “Optical and electronic signal stabilization of plasmonic fiber optic gate electrodes: Towards improved real-time dual-mode biosensing,” <i>Frontiers in Physics</i>, vol. 11. Frontiers, 2023.","ama":"Hasler R, Steger-Polt MH, Reiner-Rozman C, et al. Optical and electronic signal stabilization of plasmonic fiber optic gate electrodes: Towards improved real-time dual-mode biosensing. <i>Frontiers in Physics</i>. 2023;11. doi:<a href=\"https://doi.org/10.3389/fphy.2023.1202132\">10.3389/fphy.2023.1202132</a>","chicago":"Hasler, Roger, Marie Helene Steger-Polt, Ciril Reiner-Rozman, Stefan Fossati, Seungho Lee, Patrik Aspermair, Christoph Kleber, Maria Ibáñez, Jakub Dostalek, and Wolfgang Knoll. “Optical and Electronic Signal Stabilization of Plasmonic Fiber Optic Gate Electrodes: Towards Improved Real-Time Dual-Mode Biosensing.” <i>Frontiers in Physics</i>. Frontiers, 2023. <a href=\"https://doi.org/10.3389/fphy.2023.1202132\">https://doi.org/10.3389/fphy.2023.1202132</a>."},"author":[{"full_name":"Hasler, Roger","last_name":"Hasler","first_name":"Roger"},{"full_name":"Steger-Polt, Marie Helene","first_name":"Marie Helene","last_name":"Steger-Polt"},{"first_name":"Ciril","last_name":"Reiner-Rozman","full_name":"Reiner-Rozman, Ciril"},{"full_name":"Fossati, Stefan","last_name":"Fossati","first_name":"Stefan"},{"full_name":"Lee, Seungho","id":"BB243B88-D767-11E9-B658-BC13E6697425","first_name":"Seungho","last_name":"Lee","orcid":"0000-0002-6962-8598"},{"first_name":"Patrik","last_name":"Aspermair","full_name":"Aspermair, Patrik"},{"first_name":"Christoph","last_name":"Kleber","full_name":"Kleber, Christoph"},{"orcid":"0000-0001-5013-2843","id":"43C61214-F248-11E8-B48F-1D18A9856A87","first_name":"Maria","last_name":"Ibáñez","full_name":"Ibáñez, Maria"},{"first_name":"Jakub","last_name":"Dostalek","full_name":"Dostalek, Jakub"},{"full_name":"Knoll, Wolfgang","last_name":"Knoll","first_name":"Wolfgang"}],"month":"07","article_number":"1202132","scopus_import":"1","acknowledgement":"This project has received funding from the European Union’s Horizon 2020 Research and Innovation Programme under the Marie Skłodowska-Curie grant agreement No. 813863–BORGES. We further thank the office of the Federal Government of Lower Austria, K3-Group–Culture, Science and Education, for their financial support as part of the project “Responsive Wound Dressing”. We gratefully acknowledge the financial support from the Austrian Research Promotion Agency (FFG; 888067).\r\nWe thank the Electron Microscopy Facility at IST Austria for their support with sputter coating the FO tips and Bernhard Pichler from AIT for software development to facilitate data evaluation.","date_created":"2023-08-06T22:01:11Z","file_date_updated":"2023-08-07T07:48:11Z","date_published":"2023-07-14T00:00:00Z","title":"Optical and electronic signal stabilization of plasmonic fiber optic gate electrodes: Towards improved real-time dual-mode biosensing"}