{"_id":"12939","author":[{"last_name":"Karg","full_name":"Karg, Cornelia A.","first_name":"Cornelia A."},{"last_name":"Wang","first_name":"Pengyu","full_name":"Wang, Pengyu"},{"full_name":"Kluibenschedl, Florian","first_name":"Florian","id":"7499e70e-eb2c-11ec-b98b-f925648bc9d9","last_name":"Kluibenschedl"},{"full_name":"Müller, Thomas","first_name":"Thomas","last_name":"Müller"},{"last_name":"Allmendinger","full_name":"Allmendinger, Lars","first_name":"Lars"},{"first_name":"Angelika M.","full_name":"Vollmar, Angelika M.","last_name":"Vollmar"},{"last_name":"Moser","first_name":"Simone","full_name":"Moser, Simone"}],"doi":"10.1002/ejoc.202000692","abstract":[{"text":"Linear tetrapyrroles, called phyllobilins, are obtained as major catabolites upon chlorophyll degradation. Primarily, colorless phylloleucobilins featuring four deconjugated pyrrole units were identified. Their yellow counterparts, phylloxanthobilins, were discovered more recently. Although the two catabolites differ only by one double bond, physicochemical properties are very distinct. Moreover, the presence of the double bond seems to enhance physiologically relevant bioactivities: in contrast to phylloleucobilin, we identified a potent anti-proliferative activity for a phylloxanthobilin, and show that this natural product induces apoptotic cell death and a cell cycle arrest in cancer cells. Interestingly, upon modifying inactive phylloleucobilin by esterification, an anti-proliferative activity can be observed that increases with the chain lengths of the alkyl esters. We provide first evidence for anti-cancer activity of phyllobilins, report a novel plant source for a phylloxanthobilin, and by using paper spray MS, show that these bioactive yellow chlorophyll catabolites are more prevalent in Nature than previously assumed.","lang":"eng"}],"publication_status":"published","publication":"European Journal of Organic Chemistry","extern":"1","type":"journal_article","date_updated":"2023-05-15T07:57:14Z","volume":2020,"publication_identifier":{"issn":["1434-193X","1099-0690"]},"status":"public","page":"4499-4509","oa":1,"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","article_processing_charge":"No","month":"08","date_created":"2023-05-10T14:49:30Z","citation":{"apa":"Karg, C. A., Wang, P., Kluibenschedl, F., Müller, T., Allmendinger, L., Vollmar, A. M., &#38; Moser, S. (2020). Phylloxanthobilins are abundant linear tetrapyrroles from chlorophyll breakdown with activities against cancer cells. <i>European Journal of Organic Chemistry</i>. Wiley. <a href=\"https://doi.org/10.1002/ejoc.202000692\">https://doi.org/10.1002/ejoc.202000692</a>","chicago":"Karg, Cornelia A., Pengyu Wang, Florian Kluibenschedl, Thomas Müller, Lars Allmendinger, Angelika M. Vollmar, and Simone Moser. “Phylloxanthobilins Are Abundant Linear Tetrapyrroles from Chlorophyll Breakdown with Activities against Cancer Cells.” <i>European Journal of Organic Chemistry</i>. Wiley, 2020. <a href=\"https://doi.org/10.1002/ejoc.202000692\">https://doi.org/10.1002/ejoc.202000692</a>.","ista":"Karg CA, Wang P, Kluibenschedl F, Müller T, Allmendinger L, Vollmar AM, Moser S. 2020. Phylloxanthobilins are abundant linear tetrapyrroles from chlorophyll breakdown with activities against cancer cells. European Journal of Organic Chemistry. 2020(29), 4499–4509.","ieee":"C. A. Karg <i>et al.</i>, “Phylloxanthobilins are abundant linear tetrapyrroles from chlorophyll breakdown with activities against cancer cells,” <i>European Journal of Organic Chemistry</i>, vol. 2020, no. 29. Wiley, pp. 4499–4509, 2020.","short":"C.A. Karg, P. Wang, F. Kluibenschedl, T. Müller, L. Allmendinger, A.M. Vollmar, S. Moser, European Journal of Organic Chemistry 2020 (2020) 4499–4509.","mla":"Karg, Cornelia A., et al. “Phylloxanthobilins Are Abundant Linear Tetrapyrroles from Chlorophyll Breakdown with Activities against Cancer Cells.” <i>European Journal of Organic Chemistry</i>, vol. 2020, no. 29, Wiley, 2020, pp. 4499–509, doi:<a href=\"https://doi.org/10.1002/ejoc.202000692\">10.1002/ejoc.202000692</a>.","ama":"Karg CA, Wang P, Kluibenschedl F, et al. Phylloxanthobilins are abundant linear tetrapyrroles from chlorophyll breakdown with activities against cancer cells. <i>European Journal of Organic Chemistry</i>. 2020;2020(29):4499-4509. doi:<a href=\"https://doi.org/10.1002/ejoc.202000692\">10.1002/ejoc.202000692</a>"},"scopus_import":"1","quality_controlled":"1","title":"Phylloxanthobilins are abundant linear tetrapyrroles from chlorophyll breakdown with activities against cancer cells","main_file_link":[{"url":"https://doi.org/10.1002/ejoc.202000692","open_access":"1"}],"oa_version":"Published Version","issue":"29","language":[{"iso":"eng"}],"intvolume":"      2020","day":"09","publisher":"Wiley","year":"2020","article_type":"original","date_published":"2020-08-09T00:00:00Z","keyword":["Organic Chemistry","Physical and Theoretical Chemistry"]}