{"abstract":[{"text":"The multicellular organization of diverse systems, including embryos, intestines, and tumors relies on coordinated cell migration in curved environments. In these settings, cells establish supracellular patterns of motion, including collective rotation and invasion. While such collective modes have been studied extensively in flat systems, the consequences of geometrical and topological constraints on collective migration in curved systems are largely unknown. Here, we discover a collective mode of cell migration in rotating spherical tissues manifesting as a propagating single-wavelength velocity wave. This wave is accompanied by an apparently incompressible supracellular flow pattern featuring topological defects as dictated by the spherical topology. Using a minimal active particle model, we reveal that this collective mode arises from the effect of curvature on the active flocking behavior of a cell layer confined to a spherical surface. Our results thus identify curvature-induced velocity waves as a mode of collective cell migration, impacting the dynamical organization of 3D curved tissues.","lang":"eng"}],"department":[{"_id":"EdHa"}],"publication_status":"published","date_published":"2023-03-24T00:00:00Z","tmp":{"image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","short":"CC BY (4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode"},"date_updated":"2023-08-01T14:05:30Z","pmid":1,"article_processing_charge":"No","month":"03","day":"24","file":[{"relation":"main_file","checksum":"54f06f9eee11d43bab253f3492c983ba","file_name":"2023_NatureComm_Brandstaetter.pdf","creator":"dernst","access_level":"open_access","content_type":"application/pdf","date_updated":"2023-04-11T06:27:00Z","file_size":4146777,"date_created":"2023-04-11T06:27:00Z","file_id":"12821","success":1}],"type":"journal_article","status":"public","title":"Curvature induces active velocity waves in rotating spherical tissues","quality_controlled":"1","scopus_import":"1","publisher":"Springer Nature","date_created":"2023-04-09T22:01:00Z","user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","oa":1,"oa_version":"Published Version","language":[{"iso":"eng"}],"_id":"12818","article_number":"1643","article_type":"original","citation":{"short":"T. Brandstätter, D. Brückner, Y.L. Han, R. Alert, M. Guo, C.P. Broedersz, Nature Communications 14 (2023).","chicago":"Brandstätter, Tom, David Brückner, Yu Long Han, Ricard Alert, Ming Guo, and Chase P. Broedersz. “Curvature Induces Active Velocity Waves in Rotating Spherical Tissues.” <i>Nature Communications</i>. Springer Nature, 2023. <a href=\"https://doi.org/10.1038/s41467-023-37054-2\">https://doi.org/10.1038/s41467-023-37054-2</a>.","ista":"Brandstätter T, Brückner D, Han YL, Alert R, Guo M, Broedersz CP. 2023. Curvature induces active velocity waves in rotating spherical tissues. Nature Communications. 14, 1643.","apa":"Brandstätter, T., Brückner, D., Han, Y. L., Alert, R., Guo, M., &#38; Broedersz, C. P. (2023). Curvature induces active velocity waves in rotating spherical tissues. <i>Nature Communications</i>. Springer Nature. <a href=\"https://doi.org/10.1038/s41467-023-37054-2\">https://doi.org/10.1038/s41467-023-37054-2</a>","ama":"Brandstätter T, Brückner D, Han YL, Alert R, Guo M, Broedersz CP. Curvature induces active velocity waves in rotating spherical tissues. <i>Nature Communications</i>. 2023;14. doi:<a href=\"https://doi.org/10.1038/s41467-023-37054-2\">10.1038/s41467-023-37054-2</a>","ieee":"T. Brandstätter, D. Brückner, Y. L. Han, R. Alert, M. Guo, and C. P. Broedersz, “Curvature induces active velocity waves in rotating spherical tissues,” <i>Nature Communications</i>, vol. 14. Springer Nature, 2023.","mla":"Brandstätter, Tom, et al. “Curvature Induces Active Velocity Waves in Rotating Spherical Tissues.” <i>Nature Communications</i>, vol. 14, 1643, Springer Nature, 2023, doi:<a href=\"https://doi.org/10.1038/s41467-023-37054-2\">10.1038/s41467-023-37054-2</a>."},"publication_identifier":{"eissn":["2041-1723"]},"external_id":{"pmid":["36964141"],"isi":["000959887700008"]},"doi":"10.1038/s41467-023-37054-2","has_accepted_license":"1","publication":"Nature Communications","author":[{"full_name":"Brandstätter, Tom","first_name":"Tom","last_name":"Brandstätter"},{"orcid":"0000-0001-7205-2975","id":"e1e86031-6537-11eb-953a-f7ab92be508d","full_name":"Brückner, David","first_name":"David","last_name":"Brückner"},{"first_name":"Yu Long","last_name":"Han","full_name":"Han, Yu Long"},{"first_name":"Ricard","last_name":"Alert","full_name":"Alert, Ricard"},{"full_name":"Guo, Ming","first_name":"Ming","last_name":"Guo"},{"first_name":"Chase P.","last_name":"Broedersz","full_name":"Broedersz, Chase P."}],"ddc":["570"],"isi":1,"acknowledgement":"We thank H. Abbaszadeh, M.J. Bowick, G. Gradziuk, M.C. Marchetti, and S. Shankar for their helpful discussions. Funded by the Deutsche Forschungsgemeinschaft (DFG, German Research Foundation)—Project-ID 201269156-SFB 1032 (Project B12). D.B.B. is a NOMIS fellow supported by the NOMIS foundation and was in part supported by a DFG fellowship within the Graduate School of Quantitative Biosciences Munich (QBM) and Joachim Herz Stiftung. R.A. acknowledges support from the Human Frontier Science Program (LT000475/2018-C) and from the National Science Foundation, through the Center for the Physics of Biological Function (PHY-1734030). M.G. acknowledges support from NIH R01GM140108 and Alfred Sloan Foundation. Funded by the Deutsche Forschungsgemeinschaft (DFG, German Research Foundation)—Project-ID 201269156-SFB 1032 (Project B12).Open Access funding enabled and organized by Projekt DEAL.","file_date_updated":"2023-04-11T06:27:00Z","year":"2023","volume":14,"intvolume":"        14"}