{"department":[{"_id":"GradSch"},{"_id":"MaJö"}],"abstract":[{"text":"All visual experiences of the vertebrates begin with light being converted into electrical signals\r\nby the eye retina. Retinal ganglion cells (RGCs) are the neurons of the innermost layer of the\r\nmammal retina, and they transmit visual information to the rest of the brain.\r\nIt has been shown that RGCs vary in their morphology and genetic profiles, moreover they can\r\nbe unambiguously grouped into subtypes that share the same morphological and/or molecular\r\nproperties. However, in terms of RGCs function, it remains unclear how many distinct types\r\nthere are and what response properties their typology relies on. Even given the recent studies\r\nthat successfully classified RGCs in a patch of the retina [1] and in scotopic conditions [2], the\r\nquestion remains whether the found subtypes persist across the entire retina.\r\nIn this work, using a novel imaging method, we show that, when sampled from a large portion\r\nof the retina, RGCs can not be clearly divided into functional subtypes. We found that in\r\nphotopic conditions, which implies more prominent natural scene statistic differences across\r\nthe visual field, response properties can be exhibited by cells differently depending on their\r\nlocation in the retina, which leads to formation of a gradient of features rather than distinct\r\nclasses.\r\nThis finding suggests that RGCs follow a global organization across the visual field of the\r\nanimal, adapting each RGC subtype to the requirements imposed by the natural scene statistics.","lang":"eng"}],"publication_status":"published","date_published":"2023-02-08T00:00:00Z","article_processing_charge":"No","month":"02","supervisor":[{"last_name":"Jösch","first_name":"Maximilian A","id":"2BD278E6-F248-11E8-B48F-1D18A9856A87","full_name":"Jösch, Maximilian A","orcid":"0000-0002-3937-1330"}],"tmp":{"legal_code_url":"https://creativecommons.org/licenses/by-nc-sa/4.0/legalcode","short":"CC BY-NC-SA (4.0)","image":"/images/cc_by_nc_sa.png","name":"Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)"},"date_updated":"2024-02-09T23:30:04Z","file":[{"checksum":"57d8da3a6c749eb1556b7435fe266a5f","relation":"main_file","creator":"cchlebak","access_level":"open_access","embargo":"2024-02-08","file_name":"Thesis_Kseniia___ISTA__istaustriathesis_PDF-A.pdf","content_type":"application/pdf","date_updated":"2024-02-09T23:30:03Z","file_size":8369317,"date_created":"2023-02-09T08:03:32Z","file_id":"12532"},{"checksum":"87fb44318e4f9eb9da2ad9ad6ca8e76f","relation":"source_file","creator":"cchlebak","access_level":"closed","embargo_to":"open_access","file_name":"Thesis Kseniia - ISTA [istaustriathesis]-FINAL.zip","content_type":"application/x-zip-compressed","date_updated":"2024-02-09T23:30:03Z","date_created":"2023-02-10T09:32:06Z","file_size":11204408,"file_id":"12535"}],"license":"https://creativecommons.org/licenses/by-nc-sa/4.0/","type":"dissertation","degree_awarded":"MS","day":"08","alternative_title":["ISTA Master's Thesis"],"title":"Panoramic functional gradients across the mouse retina","status":"public","publisher":"Institute of Science and Technology Austria","oa":1,"oa_version":"Published Version","date_created":"2023-02-09T07:45:05Z","user_id":"c635000d-4b10-11ee-a964-aac5a93f6ac1","language":[{"iso":"eng"}],"_id":"12531","citation":{"mla":"Kirillova, Kseniia. <i>Panoramic Functional Gradients across the Mouse Retina</i>. Institute of Science and Technology Austria, 2023, doi:<a href=\"https://doi.org/10.15479/at:ista:12531\">10.15479/at:ista:12531</a>.","ieee":"K. Kirillova, “Panoramic functional gradients across the mouse retina,” Institute of Science and Technology Austria, 2023.","apa":"Kirillova, K. (2023). <i>Panoramic functional gradients across the mouse retina</i>. Institute of Science and Technology Austria. <a href=\"https://doi.org/10.15479/at:ista:12531\">https://doi.org/10.15479/at:ista:12531</a>","ista":"Kirillova K. 2023. Panoramic functional gradients across the mouse retina. Institute of Science and Technology Austria.","chicago":"Kirillova, Kseniia. “Panoramic Functional Gradients across the Mouse Retina.” Institute of Science and Technology Austria, 2023. <a href=\"https://doi.org/10.15479/at:ista:12531\">https://doi.org/10.15479/at:ista:12531</a>.","ama":"Kirillova K. Panoramic functional gradients across the mouse retina. 2023. doi:<a href=\"https://doi.org/10.15479/at:ista:12531\">10.15479/at:ista:12531</a>","short":"K. Kirillova, Panoramic Functional Gradients across the Mouse Retina, Institute of Science and Technology Austria, 2023."},"publication_identifier":{"issn":["2791-4585"]},"page":"46","doi":"10.15479/at:ista:12531","has_accepted_license":"1","author":[{"full_name":"Kirillova, Kseniia","id":"8e3f931e-dc85-11ea-9058-e7b957bf23f0","first_name":"Kseniia","last_name":"Kirillova"}],"ddc":["570"],"file_date_updated":"2024-02-09T23:30:03Z","year":"2023"}