{"tmp":{"legal_code_url":"https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode","image":"/images/cc_by_nc_nd.png","name":"Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)","short":"CC BY-NC-ND (4.0)"},"date_updated":"2023-08-04T09:36:21Z","pmid":1,"month":"11","article_processing_charge":"No","day":"01","file":[{"access_level":"open_access","creator":"dernst","file_name":"2022_EuropJourHaematology_Patxot.pdf","content_type":"application/pdf","checksum":"a676d732f67c2990197e34f96b219370","relation":"main_file","file_size":1225073,"date_created":"2023-01-27T11:42:43Z","success":1,"file_id":"12426","date_updated":"2023-01-27T11:42:43Z"}],"type":"journal_article","abstract":[{"text":"Background: About 800 women die every day worldwide from pregnancy-related complications, including excessive blood loss, infections and high-blood pressure (World Health Organization, 2019). To improve screening for high-risk pregnancies, we set out to identify patterns of maternal hematological changes associated with future pregnancy complications.\r\n\r\nMethods: Using mixed effects models, we established changes in 14 complete blood count (CBC) parameters for 1710 healthy pregnancies and compared them to measurements from 98 pregnancy-induced hypertension, 106 gestational diabetes and 339 postpartum hemorrhage cases.\r\n\r\nResults: Results show interindividual variations, but good individual repeatability in CBC values during physiological pregnancies, allowing the identification of specific alterations in women with obstetric complications. For example, in women with uncomplicated pregnancies, haemoglobin count decreases of 0.12 g/L (95% CI −0.16, −0.09) significantly per gestation week (p value <.001). Interestingly, this decrease is three times more pronounced in women who will develop pregnancy-induced hypertension, with an additional decrease of 0.39 g/L (95% CI −0.51, −0.26). We also confirm that obstetric complications and white CBC predict the likelihood of giving birth earlier during pregnancy.\r\n\r\nConclusion: We provide a comprehensive description of the associations between haematological changes through pregnancy and three major obstetric complications to support strategies for prevention, early-diagnosis and maternal care.","lang":"eng"}],"department":[{"_id":"MaRo"}],"issue":"5","date_published":"2022-11-01T00:00:00Z","publication_status":"published","scopus_import":"1","publisher":"Wiley","user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","date_created":"2023-01-16T09:50:58Z","oa":1,"oa_version":"Published Version","status":"public","quality_controlled":"1","title":"Haematological changes from conception to childbirth: An indicator of major pregnancy complications","publication_identifier":{"eissn":["1600-0609"],"issn":["0902-4441"]},"external_id":{"pmid":["36059200"],"isi":["000849690500001"]},"page":"566-575","doi":"10.1111/ejh.13844","author":[{"full_name":"Patxot, Marion","last_name":"Patxot","first_name":"Marion"},{"first_name":"Miloš","last_name":"Stojanov","full_name":"Stojanov, Miloš"},{"full_name":"Ojavee, Sven Erik","last_name":"Ojavee","first_name":"Sven Erik"},{"full_name":"Gobert, Rosanna Pescini","last_name":"Gobert","first_name":"Rosanna Pescini"},{"last_name":"Kutalik","first_name":"Zoltán","full_name":"Kutalik, Zoltán"},{"full_name":"Gavillet, Mathilde","first_name":"Mathilde","last_name":"Gavillet"},{"first_name":"David","last_name":"Baud","full_name":"Baud, David"},{"orcid":"0000-0001-8982-8813","id":"E5D42276-F5DA-11E9-8E24-6303E6697425","full_name":"Robinson, Matthew Richard","last_name":"Robinson","first_name":"Matthew Richard"}],"publication":"European Journal of Haematology","has_accepted_license":"1","language":[{"iso":"eng"}],"_id":"12235","citation":{"ieee":"M. Patxot <i>et al.</i>, “Haematological changes from conception to childbirth: An indicator of major pregnancy complications,” <i>European Journal of Haematology</i>, vol. 109, no. 5. Wiley, pp. 566–575, 2022.","mla":"Patxot, Marion, et al. “Haematological Changes from Conception to Childbirth: An Indicator of Major Pregnancy Complications.” <i>European Journal of Haematology</i>, vol. 109, no. 5, Wiley, 2022, pp. 566–75, doi:<a href=\"https://doi.org/10.1111/ejh.13844\">10.1111/ejh.13844</a>.","short":"M. Patxot, M. Stojanov, S.E. Ojavee, R.P. Gobert, Z. Kutalik, M. Gavillet, D. Baud, M.R. Robinson, European Journal of Haematology 109 (2022) 566–575.","ama":"Patxot M, Stojanov M, Ojavee SE, et al. Haematological changes from conception to childbirth: An indicator of major pregnancy complications. <i>European Journal of Haematology</i>. 2022;109(5):566-575. doi:<a href=\"https://doi.org/10.1111/ejh.13844\">10.1111/ejh.13844</a>","ista":"Patxot M, Stojanov M, Ojavee SE, Gobert RP, Kutalik Z, Gavillet M, Baud D, Robinson MR. 2022. Haematological changes from conception to childbirth: An indicator of major pregnancy complications. European Journal of Haematology. 109(5), 566–575.","chicago":"Patxot, Marion, Miloš Stojanov, Sven Erik Ojavee, Rosanna Pescini Gobert, Zoltán Kutalik, Mathilde Gavillet, David Baud, and Matthew Richard Robinson. “Haematological Changes from Conception to Childbirth: An Indicator of Major Pregnancy Complications.” <i>European Journal of Haematology</i>. Wiley, 2022. <a href=\"https://doi.org/10.1111/ejh.13844\">https://doi.org/10.1111/ejh.13844</a>.","apa":"Patxot, M., Stojanov, M., Ojavee, S. E., Gobert, R. P., Kutalik, Z., Gavillet, M., … Robinson, M. R. (2022). Haematological changes from conception to childbirth: An indicator of major pregnancy complications. <i>European Journal of Haematology</i>. Wiley. <a href=\"https://doi.org/10.1111/ejh.13844\">https://doi.org/10.1111/ejh.13844</a>"},"article_type":"original","year":"2022","volume":109,"intvolume":"       109","ddc":["570","610"],"acknowledgement":"This project was funded by an SNSF Eccellenza Grant to MRR (PCEGP3-181181), and by core funding from the Institute of Science and Technology Austria. We would like to thank the participants of the study and all the midwives and doctors involved for the computerized obstetrical data from the CHUV Maternity Hospital. Open access funding provided by Universite de Lausanne.","isi":1,"keyword":["Hematology","General Medicine"],"file_date_updated":"2023-01-27T11:42:43Z"}