{"publication":"RSC Advances","publication_status":"published","issue":"26","oa_version":"None","abstract":[{"lang":"eng","text":"A method for the direct lithiation of terminal alkynes and heterocycles with subsequent carboxylation in a continuous flow format was developed. This method provides carboxylic acids at ambient conditions within less than five seconds with only little excess of the organometallic base and CO2."}],"article_number":"13430","doi":"10.1039/c4ra01442a","author":[{"id":"93e5e5b2-0da6-11ed-8a41-af589a024726","last_name":"Pieber","orcid":"0000-0001-8689-388X","first_name":"Bartholomäus","full_name":"Pieber, Bartholomäus"},{"first_name":"Toma","full_name":"Glasnov, Toma","last_name":"Glasnov"},{"first_name":"C. O.","full_name":"Kappe, C. O.","last_name":"Kappe"}],"_id":"11987","title":"Flash carboxylation: Fast lithiation–carboxylation sequence at room temperature in continuous flow","quality_controlled":"1","scopus_import":"1","intvolume":"         4","publication_identifier":{"eissn":["2046-2069"]},"language":[{"iso":"eng"}],"volume":4,"date_updated":"2023-02-21T10:10:31Z","type":"journal_article","extern":"1","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","date_published":"2014-03-03T00:00:00Z","year":"2014","status":"public","article_type":"letter_note","publisher":"Royal Society of Chemistry","day":"03","citation":{"ieee":"B. Pieber, T. Glasnov, and C. O. Kappe, “Flash carboxylation: Fast lithiation–carboxylation sequence at room temperature in continuous flow,” <i>RSC Advances</i>, vol. 4, no. 26. Royal Society of Chemistry, 2014.","ama":"Pieber B, Glasnov T, Kappe CO. Flash carboxylation: Fast lithiation–carboxylation sequence at room temperature in continuous flow. <i>RSC Advances</i>. 2014;4(26). doi:<a href=\"https://doi.org/10.1039/c4ra01442a\">10.1039/c4ra01442a</a>","mla":"Pieber, Bartholomäus, et al. “Flash Carboxylation: Fast Lithiation–Carboxylation Sequence at Room Temperature in Continuous Flow.” <i>RSC Advances</i>, vol. 4, no. 26, 13430, Royal Society of Chemistry, 2014, doi:<a href=\"https://doi.org/10.1039/c4ra01442a\">10.1039/c4ra01442a</a>.","short":"B. Pieber, T. Glasnov, C.O. Kappe, RSC Advances 4 (2014).","apa":"Pieber, B., Glasnov, T., &#38; Kappe, C. O. (2014). Flash carboxylation: Fast lithiation–carboxylation sequence at room temperature in continuous flow. <i>RSC Advances</i>. Royal Society of Chemistry. <a href=\"https://doi.org/10.1039/c4ra01442a\">https://doi.org/10.1039/c4ra01442a</a>","ista":"Pieber B, Glasnov T, Kappe CO. 2014. Flash carboxylation: Fast lithiation–carboxylation sequence at room temperature in continuous flow. RSC Advances. 4(26), 13430.","chicago":"Pieber, Bartholomäus, Toma Glasnov, and C. O. Kappe. “Flash Carboxylation: Fast Lithiation–Carboxylation Sequence at Room Temperature in Continuous Flow.” <i>RSC Advances</i>. Royal Society of Chemistry, 2014. <a href=\"https://doi.org/10.1039/c4ra01442a\">https://doi.org/10.1039/c4ra01442a</a>."},"date_created":"2022-08-25T11:48:19Z","month":"03","article_processing_charge":"No"}