{"publication_identifier":{"eissn":["2058-9883"]},"volume":5,"date_updated":"2023-02-21T10:10:28Z","type":"journal_article","extern":"1","publication_status":"published","publication":"Reaction Chemistry and Engineering","abstract":[{"text":"Carbon nitride materials have emerged as an efficient and sustainable class of heterogeneous photocatalysts, particularly when paired with nickel in dual catalytic cross-coupling reactions. Performing these transformations on larger scales using a continuous process is difficult due to the problems associated with handling solids in flow. By combining an oscillatory pump with a microstructured plug flow photoreactor, a stable suspension of the photocatalyst can be maintained, circumventing clogging of the reactor channels. Through careful tuning of the oscillator properties, the residence time distribution (RTD) was optimized, whilst maintaining a stable catalyst suspension. Short residence times (20 min) were achieved using optimized conditions and the recyclability of the photocatalyst was demonstrated over 10 cycles with no loss of activity. During a stable 4.5 hour scale-out demonstration, the model substrate could be isolated on 12 g scale (90% yield, 2.67 g h−1). Moreover, the method was applied for the gram scale synthesis of an intermediate of the active pharmaceutical ingredient tetracaine.","lang":"eng"}],"doi":"10.1039/d0re00036a","author":[{"last_name":"Rosso","first_name":"Cristian","full_name":"Rosso, Cristian"},{"last_name":"Gisbertz","full_name":"Gisbertz, Sebastian","first_name":"Sebastian"},{"first_name":"Jason D.","full_name":"Williams, Jason D.","last_name":"Williams"},{"last_name":"Gemoets","first_name":"Hannes P. L.","full_name":"Gemoets, Hannes P. L."},{"full_name":"Debrouwer, Wouter","first_name":"Wouter","last_name":"Debrouwer"},{"last_name":"Pieber","id":"93e5e5b2-0da6-11ed-8a41-af589a024726","first_name":"Bartholomäus","full_name":"Pieber, Bartholomäus","orcid":"0000-0001-8689-388X"},{"first_name":"C. Oliver","full_name":"Kappe, C. Oliver","last_name":"Kappe"}],"_id":"11986","citation":{"ista":"Rosso C, Gisbertz S, Williams JD, Gemoets HPL, Debrouwer W, Pieber B, Kappe CO. 2020. An oscillatory plug flow photoreactor facilitates semi-heterogeneous dual nickel/carbon nitride photocatalytic C–N couplings. Reaction Chemistry and Engineering. 5(3), 597–604.","chicago":"Rosso, Cristian, Sebastian Gisbertz, Jason D. Williams, Hannes P. L. Gemoets, Wouter Debrouwer, Bartholomäus Pieber, and C. Oliver Kappe. “An Oscillatory Plug Flow Photoreactor Facilitates Semi-Heterogeneous Dual Nickel/Carbon Nitride Photocatalytic C–N Couplings.” <i>Reaction Chemistry and Engineering</i>. Royal Society of Chemistry, 2020. <a href=\"https://doi.org/10.1039/d0re00036a\">https://doi.org/10.1039/d0re00036a</a>.","apa":"Rosso, C., Gisbertz, S., Williams, J. D., Gemoets, H. P. L., Debrouwer, W., Pieber, B., &#38; Kappe, C. O. (2020). An oscillatory plug flow photoreactor facilitates semi-heterogeneous dual nickel/carbon nitride photocatalytic C–N couplings. <i>Reaction Chemistry and Engineering</i>. Royal Society of Chemistry. <a href=\"https://doi.org/10.1039/d0re00036a\">https://doi.org/10.1039/d0re00036a</a>","short":"C. Rosso, S. Gisbertz, J.D. Williams, H.P.L. Gemoets, W. Debrouwer, B. Pieber, C.O. Kappe, Reaction Chemistry and Engineering 5 (2020) 597–604.","mla":"Rosso, Cristian, et al. “An Oscillatory Plug Flow Photoreactor Facilitates Semi-Heterogeneous Dual Nickel/Carbon Nitride Photocatalytic C–N Couplings.” <i>Reaction Chemistry and Engineering</i>, vol. 5, no. 3, Royal Society of Chemistry, 2020, pp. 597–604, doi:<a href=\"https://doi.org/10.1039/d0re00036a\">10.1039/d0re00036a</a>.","ama":"Rosso C, Gisbertz S, Williams JD, et al. An oscillatory plug flow photoreactor facilitates semi-heterogeneous dual nickel/carbon nitride photocatalytic C–N couplings. <i>Reaction Chemistry and Engineering</i>. 2020;5(3):597-604. doi:<a href=\"https://doi.org/10.1039/d0re00036a\">10.1039/d0re00036a</a>","ieee":"C. Rosso <i>et al.</i>, “An oscillatory plug flow photoreactor facilitates semi-heterogeneous dual nickel/carbon nitride photocatalytic C–N couplings,” <i>Reaction Chemistry and Engineering</i>, vol. 5, no. 3. Royal Society of Chemistry, pp. 597–604, 2020."},"date_created":"2022-08-25T11:45:02Z","month":"03","article_processing_charge":"No","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","oa":1,"page":"597-604","status":"public","intvolume":"         5","language":[{"iso":"eng"}],"issue":"3","oa_version":"Published Version","main_file_link":[{"open_access":"1","url":"https://doi.org/10.1039/D0RE00036A"}],"title":"An oscillatory plug flow photoreactor facilitates semi-heterogeneous dual nickel/carbon nitride photocatalytic C–N couplings","quality_controlled":"1","scopus_import":"1","date_published":"2020-03-01T00:00:00Z","year":"2020","publisher":"Royal Society of Chemistry","article_type":"original","day":"01"}