{"extern":"1","type":"journal_article","date_updated":"2022-07-18T08:57:04Z","volume":312,"publication_identifier":{"issn":["0036-8075","1095-9203"]},"_id":"11118","doi":"10.1126/science.1124196","author":[{"first_name":"Maximiliano A.","full_name":"D'Angelo, Maximiliano A.","last_name":"D'Angelo"},{"last_name":"Anderson","first_name":"Daniel J.","full_name":"Anderson, Daniel J."},{"last_name":"Richard","first_name":"Erin","full_name":"Richard, Erin"},{"first_name":"Martin W","full_name":"HETZER, Martin W","orcid":"0000-0002-2111-992X","last_name":"HETZER","id":"86c0d31b-b4eb-11ec-ac5a-eae7b2e135ed"}],"abstract":[{"lang":"eng","text":"Nuclear pore complexes are multiprotein channels that span the double lipid bilayer of the nuclear envelope. How new pores are inserted into the intact nuclear envelope of proliferating and differentiating eukaryotic cells is unknown. We found that the Nup107-160 complex was incorporated into assembly sites in the nuclear envelope from both the nucleoplasmic and the cytoplasmic sides. Nuclear pore insertion required the generation of Ran guanosine triphosphate in the nuclear and cytoplasmic compartments. Newly formed nuclear pore complexes did not contain structural components of preexisting pores, suggesting that they can form de novo."}],"publication_status":"published","publication":"Science","article_processing_charge":"No","month":"04","date_created":"2022-04-07T07:56:32Z","citation":{"ieee":"M. A. D’Angelo, D. J. Anderson, E. Richard, and M. Hetzer, “Nuclear pores form de novo from both sides of the nuclear envelope,” <i>Science</i>, vol. 312, no. 5772. American Association for the Advancement of Science, pp. 440–443, 2006.","mla":"D’Angelo, Maximiliano A., et al. “Nuclear Pores Form de Novo from Both Sides of the Nuclear Envelope.” <i>Science</i>, vol. 312, no. 5772, American Association for the Advancement of Science, 2006, pp. 440–43, doi:<a href=\"https://doi.org/10.1126/science.1124196\">10.1126/science.1124196</a>.","ama":"D’Angelo MA, Anderson DJ, Richard E, Hetzer M. Nuclear pores form de novo from both sides of the nuclear envelope. <i>Science</i>. 2006;312(5772):440-443. doi:<a href=\"https://doi.org/10.1126/science.1124196\">10.1126/science.1124196</a>","short":"M.A. D’Angelo, D.J. Anderson, E. Richard, M. Hetzer, Science 312 (2006) 440–443.","apa":"D’Angelo, M. A., Anderson, D. J., Richard, E., &#38; Hetzer, M. (2006). Nuclear pores form de novo from both sides of the nuclear envelope. <i>Science</i>. American Association for the Advancement of Science. <a href=\"https://doi.org/10.1126/science.1124196\">https://doi.org/10.1126/science.1124196</a>","chicago":"D’Angelo, Maximiliano A., Daniel J. Anderson, Erin Richard, and Martin Hetzer. “Nuclear Pores Form de Novo from Both Sides of the Nuclear Envelope.” <i>Science</i>. American Association for the Advancement of Science, 2006. <a href=\"https://doi.org/10.1126/science.1124196\">https://doi.org/10.1126/science.1124196</a>.","ista":"D’Angelo MA, Anderson DJ, Richard E, Hetzer M. 2006. Nuclear pores form de novo from both sides of the nuclear envelope. Science. 312(5772), 440–443."},"external_id":{"pmid":["16627745"]},"status":"public","page":"440-443","user_id":"72615eeb-f1f3-11ec-aa25-d4573ddc34fd","language":[{"iso":"eng"}],"intvolume":"       312","quality_controlled":"1","scopus_import":"1","title":"Nuclear pores form de novo from both sides of the nuclear envelope","oa_version":"None","issue":"5772","keyword":["Multidisciplinary"],"pmid":1,"day":"21","article_type":"original","publisher":"American Association for the Advancement of Science","year":"2006","date_published":"2006-04-21T00:00:00Z"}