Geometric control and modeling of genome reprogramming - Uhler, Caroline; Shivashankar, G V (BioArchitecture, 2016)
Cell geometry is tightly coupled to gene expression patterns within the tissue microenvironment. This perspective synthesizes evidence that the 3D organization of chromosomes is a critical intermediate for geometric control of genomic programs. Using a combination of experiments and modeling we outline approaches to decipher the mechano-genomic code that governs cellular homeostasis and reprogramming.
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Keywords: article