{"status":"public","page":"7804-7817","external_id":{"arxiv":["1608.05788"],"pmid":["27722701"]},"user_id":"8b945eb4-e2f2-11eb-945a-df72226e66a9","oa":1,"article_processing_charge":"No","citation":{"ieee":"S. J. Bachmann <i>et al.</i>, “Melting transition in lipid vesicles functionalised by mobile DNA linkers,” <i>Soft Matter</i>, vol. 12, no. 37. Royal Society of Chemistry, pp. 7804–7817, 2016.","short":"S.J. Bachmann, J. Kotar, L. Parolini, A. Šarić, P. Cicuta, L. Di Michele, B.M. Mognetti, Soft Matter 12 (2016) 7804–7817.","mla":"Bachmann, Stephan Jan, et al. “Melting Transition in Lipid Vesicles Functionalised by Mobile DNA Linkers.” <i>Soft Matter</i>, vol. 12, no. 37, Royal Society of Chemistry, 2016, pp. 7804–17, doi:<a href=\"https://doi.org/10.1039/c6sm01515h\">10.1039/c6sm01515h</a>.","ama":"Bachmann SJ, Kotar J, Parolini L, et al. Melting transition in lipid vesicles functionalised by mobile DNA linkers. <i>Soft Matter</i>. 2016;12(37):7804-7817. doi:<a href=\"https://doi.org/10.1039/c6sm01515h\">10.1039/c6sm01515h</a>","apa":"Bachmann, S. J., Kotar, J., Parolini, L., Šarić, A., Cicuta, P., Di Michele, L., &#38; Mognetti, B. M. (2016). Melting transition in lipid vesicles functionalised by mobile DNA linkers. <i>Soft Matter</i>. Royal Society of Chemistry. <a href=\"https://doi.org/10.1039/c6sm01515h\">https://doi.org/10.1039/c6sm01515h</a>","chicago":"Bachmann, Stephan Jan, Jurij Kotar, Lucia Parolini, Anđela Šarić, Pietro Cicuta, Lorenzo Di Michele, and Bortolo Matteo Mognetti. “Melting Transition in Lipid Vesicles Functionalised by Mobile DNA Linkers.” <i>Soft Matter</i>. Royal Society of Chemistry, 2016. <a href=\"https://doi.org/10.1039/c6sm01515h\">https://doi.org/10.1039/c6sm01515h</a>.","ista":"Bachmann SJ, Kotar J, Parolini L, Šarić A, Cicuta P, Di Michele L, Mognetti BM. 2016. Melting transition in lipid vesicles functionalised by mobile DNA linkers. Soft Matter. 12(37), 7804–7817."},"month":"08","date_created":"2021-11-29T11:09:55Z","_id":"10381","doi":"10.1039/c6sm01515h","author":[{"full_name":"Bachmann, Stephan Jan","first_name":"Stephan Jan","last_name":"Bachmann"},{"full_name":"Kotar, Jurij","first_name":"Jurij","last_name":"Kotar"},{"full_name":"Parolini, Lucia","first_name":"Lucia","last_name":"Parolini"},{"last_name":"Šarić","id":"bf63d406-f056-11eb-b41d-f263a6566d8b","first_name":"Anđela","full_name":"Šarić, Anđela","orcid":"0000-0002-7854-2139"},{"first_name":"Pietro","full_name":"Cicuta, Pietro","last_name":"Cicuta"},{"last_name":"Di Michele","first_name":"Lorenzo","full_name":"Di Michele, Lorenzo"},{"full_name":"Mognetti, Bortolo Matteo","first_name":"Bortolo Matteo","last_name":"Mognetti"}],"publication":"Soft Matter","publication_status":"published","abstract":[{"lang":"eng","text":"We study phase behaviour of lipid-bilayer vesicles functionalised by ligand–receptor complexes made of synthetic DNA by introducing a modelling framework and a dedicated experimental platform. In particular, we perform Monte Carlo simulations that combine a coarse grained description of the lipid bilayer with state of art analytical models for multivalent ligand–receptor interactions. Using density of state calculations, we derive the partition function in pairs of vesicles and compute the number of ligand–receptor bonds as a function of temperature. Numerical results are compared to microscopy and fluorimetry experiments on large unilamellar vesicles decorated by DNA linkers carrying complementary overhangs. We find that vesicle aggregation is suppressed when the total number of linkers falls below a threshold value. Within the model proposed here, this is due to the higher configurational costs required to form inter-vesicle bridges as compared to intra-vesicle loops, which are in turn related to membrane deformability. Our findings and our numerical/experimental methodologies are applicable to the rational design of liposomes used as functional materials and drug delivery applications, as well as to study inter-membrane interactions in living systems, such as cell adhesion."}],"date_updated":"2021-11-29T13:09:00Z","volume":12,"extern":"1","type":"journal_article","publication_identifier":{"eissn":["1744-6848"],"issn":["1744-683X"]},"year":"2016","article_type":"original","publisher":"Royal Society of Chemistry","day":"19","date_published":"2016-08-19T00:00:00Z","pmid":1,"keyword":["condensed matter physics","general chemistry"],"main_file_link":[{"open_access":"1","url":"https://arxiv.org/abs/1608.05788"}],"scopus_import":"1","quality_controlled":"1","title":"Melting transition in lipid vesicles functionalised by mobile DNA linkers","issue":"37","oa_version":"Preprint","intvolume":"        12","language":[{"iso":"eng"}]}