{"scopus_import":"1","quality_controlled":"1","title":"Dynamic clustering regulates activity of mechanosensitive membrane channels","main_file_link":[{"url":"https://www.biorxiv.org/content/10.1101/553248","open_access":"1"}],"oa_version":"Preprint","issue":"4","language":[{"iso":"eng"}],"intvolume":"       124","day":"31","year":"2020","article_type":"original","publisher":"American Physical Society","date_published":"2020-01-31T00:00:00Z","keyword":["general physics and astronomy"],"pmid":1,"_id":"10353","doi":"10.1103/physrevlett.124.048102","author":[{"first_name":"Alexandru","full_name":"Paraschiv, Alexandru","last_name":"Paraschiv"},{"last_name":"Hegde","full_name":"Hegde, Smitha","first_name":"Smitha"},{"first_name":"Raman","full_name":"Ganti, Raman","last_name":"Ganti"},{"last_name":"Pilizota","first_name":"Teuta","full_name":"Pilizota, Teuta"},{"last_name":"Šarić","id":"bf63d406-f056-11eb-b41d-f263a6566d8b","full_name":"Šarić, Anđela","first_name":"Anđela","orcid":"0000-0002-7854-2139"}],"article_number":"048102","abstract":[{"lang":"eng","text":"Experiments have suggested that bacterial mechanosensitive channels separate into 2D clusters, the role of which is unclear. By developing a coarse-grained computer model we find that clustering promotes the channel closure, which is highly dependent on the channel concentration and membrane stress. This behaviour yields a tightly regulated gating system, whereby at high tensions channels gate individually, and at lower tensions the channels spontaneously aggregate and inactivate. We implement this positive feedback into the model for cell volume regulation, and find that the channel clustering protects the cell against excessive loss of cytoplasmic content."}],"publication":"Physical Review Letters","publication_status":"published","extern":"1","type":"journal_article","date_updated":"2021-11-26T11:21:12Z","volume":124,"publication_identifier":{"issn":["0031-9007"],"eissn":["1079-7114"]},"external_id":{"pmid":["32058787"]},"status":"public","oa":1,"user_id":"8b945eb4-e2f2-11eb-945a-df72226e66a9","acknowledgement":"We thank Samantha Miller, Bert Poolman, and the members of Šarić and Pilizota laboratories for useful discussion. We acknowledge support from the Engineering and Physical Sciences Research Council (A.P. and A.Š.), the UCL Institute for the Physics of Living Systems (A.P. and A.Š.), Darwin Trust of University of Edinburgh (H.S.), Industrial Biotechnology Innovation Centre (H.S. and T.P.), BBSRC Council Crossing Biological Membrane Network (H.S. and T.P.), BBSRC/EPSRC/MRC Synthetic Biology Research Centre (T.P.), and the Royal Society (A.Š.).","article_processing_charge":"No","month":"01","date_created":"2021-11-26T09:57:01Z","citation":{"apa":"Paraschiv, A., Hegde, S., Ganti, R., Pilizota, T., &#38; Šarić, A. (2020). Dynamic clustering regulates activity of mechanosensitive membrane channels. <i>Physical Review Letters</i>. American Physical Society. <a href=\"https://doi.org/10.1103/physrevlett.124.048102\">https://doi.org/10.1103/physrevlett.124.048102</a>","chicago":"Paraschiv, Alexandru, Smitha Hegde, Raman Ganti, Teuta Pilizota, and Anđela Šarić. “Dynamic Clustering Regulates Activity of Mechanosensitive Membrane Channels.” <i>Physical Review Letters</i>. American Physical Society, 2020. <a href=\"https://doi.org/10.1103/physrevlett.124.048102\">https://doi.org/10.1103/physrevlett.124.048102</a>.","ista":"Paraschiv A, Hegde S, Ganti R, Pilizota T, Šarić A. 2020. Dynamic clustering regulates activity of mechanosensitive membrane channels. Physical Review Letters. 124(4), 048102.","ieee":"A. Paraschiv, S. Hegde, R. Ganti, T. Pilizota, and A. Šarić, “Dynamic clustering regulates activity of mechanosensitive membrane channels,” <i>Physical Review Letters</i>, vol. 124, no. 4. American Physical Society, 2020.","ama":"Paraschiv A, Hegde S, Ganti R, Pilizota T, Šarić A. Dynamic clustering regulates activity of mechanosensitive membrane channels. <i>Physical Review Letters</i>. 2020;124(4). doi:<a href=\"https://doi.org/10.1103/physrevlett.124.048102\">10.1103/physrevlett.124.048102</a>","mla":"Paraschiv, Alexandru, et al. “Dynamic Clustering Regulates Activity of Mechanosensitive Membrane Channels.” <i>Physical Review Letters</i>, vol. 124, no. 4, 048102, American Physical Society, 2020, doi:<a href=\"https://doi.org/10.1103/physrevlett.124.048102\">10.1103/physrevlett.124.048102</a>.","short":"A. Paraschiv, S. Hegde, R. Ganti, T. Pilizota, A. Šarić, Physical Review Letters 124 (2020)."}}