{"article_type":"original","publisher":"American Physical Society","year":"2020","day":"23","tmp":{"short":"CC BY (4.0)","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","image":"/images/cc_by.png","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode"},"date_published":"2020-11-23T00:00:00Z","pmid":1,"main_file_link":[{"url":"https://www.biorxiv.org/content/10.1101/2020.02.27.968149v1","open_access":"1"}],"quality_controlled":"1","scopus_import":"1","title":"Exploring the design rules for efficient membrane-reshaping nanostructures","issue":"22","oa_version":"Published Version","file":[{"file_size":844353,"content_type":"application/pdf","file_id":"10345","creator":"cchlebak","date_updated":"2021-11-26T07:16:49Z","date_created":"2021-11-26T07:16:49Z","checksum":"fbf2e1415e332d6add90222d60401a1d","access_level":"open_access","success":1,"relation":"main_file","file_name":"2020_PhysRevLett_Forster.pdf"}],"intvolume":"       125","language":[{"iso":"eng"}],"status":"public","external_id":{"pmid":["33315453"]},"ddc":["530"],"user_id":"8b945eb4-e2f2-11eb-945a-df72226e66a9","oa":1,"file_date_updated":"2021-11-26T07:16:49Z","acknowledgement":"We acknowledge support from EPSRC (J. C. F.), MRC (B. B. and A. Š.), the ERC StG 802960 “NEPA” (J. K. and A. Š.), the Royal Society (A. Š.), and the United Kingdom Materials and Molecular Modelling Hub for computational resources, which is partially funded by EPSRC (EP/P020194/1).","article_processing_charge":"No","citation":{"short":"J.C. Forster, J. Krausser, M.R. Vuyyuru, B. Baum, A. Šarić, Physical Review Letters 125 (2020).","ama":"Forster JC, Krausser J, Vuyyuru MR, Baum B, Šarić A. Exploring the design rules for efficient membrane-reshaping nanostructures. <i>Physical Review Letters</i>. 2020;125(22). doi:<a href=\"https://doi.org/10.1103/physrevlett.125.228101\">10.1103/physrevlett.125.228101</a>","mla":"Forster, Joel C., et al. “Exploring the Design Rules for Efficient Membrane-Reshaping Nanostructures.” <i>Physical Review Letters</i>, vol. 125, no. 22, 228101, American Physical Society, 2020, doi:<a href=\"https://doi.org/10.1103/physrevlett.125.228101\">10.1103/physrevlett.125.228101</a>.","ieee":"J. C. Forster, J. Krausser, M. R. Vuyyuru, B. Baum, and A. Šarić, “Exploring the design rules for efficient membrane-reshaping nanostructures,” <i>Physical Review Letters</i>, vol. 125, no. 22. American Physical Society, 2020.","chicago":"Forster, Joel C., Johannes Krausser, Manish R. Vuyyuru, Buzz Baum, and Anđela Šarić. “Exploring the Design Rules for Efficient Membrane-Reshaping Nanostructures.” <i>Physical Review Letters</i>. American Physical Society, 2020. <a href=\"https://doi.org/10.1103/physrevlett.125.228101\">https://doi.org/10.1103/physrevlett.125.228101</a>.","ista":"Forster JC, Krausser J, Vuyyuru MR, Baum B, Šarić A. 2020. Exploring the design rules for efficient membrane-reshaping nanostructures. Physical Review Letters. 125(22), 228101.","apa":"Forster, J. C., Krausser, J., Vuyyuru, M. R., Baum, B., &#38; Šarić, A. (2020). Exploring the design rules for efficient membrane-reshaping nanostructures. <i>Physical Review Letters</i>. American Physical Society. <a href=\"https://doi.org/10.1103/physrevlett.125.228101\">https://doi.org/10.1103/physrevlett.125.228101</a>"},"month":"11","date_created":"2021-11-26T07:10:43Z","_id":"10344","author":[{"full_name":"Forster, Joel C.","first_name":"Joel C.","last_name":"Forster"},{"last_name":"Krausser","full_name":"Krausser, Johannes","first_name":"Johannes"},{"last_name":"Vuyyuru","first_name":"Manish R.","full_name":"Vuyyuru, Manish R."},{"last_name":"Baum","first_name":"Buzz","full_name":"Baum, Buzz"},{"last_name":"Šarić","id":"bf63d406-f056-11eb-b41d-f263a6566d8b","full_name":"Šarić, Anđela","first_name":"Anđela","orcid":"0000-0002-7854-2139"}],"doi":"10.1103/physrevlett.125.228101","publication":"Physical Review Letters","publication_status":"published","abstract":[{"lang":"eng","text":"In this study, we investigate the role of the surface patterning of nanostructures for cell membrane reshaping. To accomplish this, we combine an evolutionary algorithm with coarse-grained molecular dynamics simulations and explore the solution space of ligand patterns on a nanoparticle that promote efficient and reliable cell uptake. Surprisingly, we find that in the regime of low ligand number the best-performing structures are characterized by ligands arranged into long one-dimensional chains that pattern the surface of the particle. We show that these chains of ligands provide particles with high rotational freedom and they lower the free energy barrier for membrane crossing. Our approach reveals a set of nonintuitive design rules that can be used to inform artificial nanoparticle construction and the search for inhibitors of viral entry."}],"article_number":"228101","date_updated":"2021-11-30T08:33:14Z","volume":125,"extern":"1","type":"journal_article","has_accepted_license":"1","publication_identifier":{"issn":["0031-9007"],"eissn":["1079-7114"]}}