{"volume":11,"intvolume":"        11","year":"2021","acknowledgement":"This project was funded by an SNSF Eccellenza Grant to MRR (PCEGP3-181181), and by core funding from the Institute of Science and Technology Austria. We would like to thank the participants of the study and all the midwives and doctors for the computerized obstetrical data.","isi":1,"file_date_updated":"2021-10-05T14:56:48Z","ddc":["618"],"has_accepted_license":"1","author":[{"full_name":"Robinson, Matthew Richard","id":"E5D42276-F5DA-11E9-8E24-6303E6697425","last_name":"Robinson","first_name":"Matthew Richard","orcid":"0000-0001-8982-8813"},{"first_name":"Marion","last_name":"Patxot","full_name":"Patxot, Marion"},{"last_name":"Stojanov","first_name":"Miloš","full_name":"Stojanov, Miloš"},{"last_name":"Blum","first_name":"Sabine","full_name":"Blum, Sabine"},{"first_name":"David","last_name":"Baud","full_name":"Baud, David"}],"publication":"Scientific Reports","doi":"10.1038/s41598-021-98411-z","publication_identifier":{"eissn":["2045-2322"]},"external_id":{"isi":["000701575500083"],"pmid":["34584125"]},"citation":{"short":"M.R. Robinson, M. Patxot, M. Stojanov, S. Blum, D. Baud, Scientific Reports 11 (2021).","chicago":"Robinson, Matthew Richard, Marion Patxot, Miloš Stojanov, Sabine Blum, and David Baud. “Postpartum Hemorrhage Risk Is Driven by Changes in Blood Composition through Pregnancy.” <i>Scientific Reports</i>. Springer Nature, 2021. <a href=\"https://doi.org/10.1038/s41598-021-98411-z\">https://doi.org/10.1038/s41598-021-98411-z</a>.","apa":"Robinson, M. R., Patxot, M., Stojanov, M., Blum, S., &#38; Baud, D. (2021). Postpartum hemorrhage risk is driven by changes in blood composition through pregnancy. <i>Scientific Reports</i>. Springer Nature. <a href=\"https://doi.org/10.1038/s41598-021-98411-z\">https://doi.org/10.1038/s41598-021-98411-z</a>","ista":"Robinson MR, Patxot M, Stojanov M, Blum S, Baud D. 2021. Postpartum hemorrhage risk is driven by changes in blood composition through pregnancy. Scientific Reports. 11, 19238.","ama":"Robinson MR, Patxot M, Stojanov M, Blum S, Baud D. Postpartum hemorrhage risk is driven by changes in blood composition through pregnancy. <i>Scientific Reports</i>. 2021;11. doi:<a href=\"https://doi.org/10.1038/s41598-021-98411-z\">10.1038/s41598-021-98411-z</a>","ieee":"M. R. Robinson, M. Patxot, M. Stojanov, S. Blum, and D. Baud, “Postpartum hemorrhage risk is driven by changes in blood composition through pregnancy,” <i>Scientific Reports</i>, vol. 11. Springer Nature, 2021.","mla":"Robinson, Matthew Richard, et al. “Postpartum Hemorrhage Risk Is Driven by Changes in Blood Composition through Pregnancy.” <i>Scientific Reports</i>, vol. 11, 19238, Springer Nature, 2021, doi:<a href=\"https://doi.org/10.1038/s41598-021-98411-z\">10.1038/s41598-021-98411-z</a>."},"article_type":"original","article_number":"19238","_id":"10069","language":[{"iso":"eng"}],"date_created":"2021-10-03T22:01:21Z","user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","oa_version":"Published Version","oa":1,"scopus_import":"1","publisher":"Springer Nature","status":"public","quality_controlled":"1","title":"Postpartum hemorrhage risk is driven by changes in blood composition through pregnancy","day":"28","type":"journal_article","file":[{"file_name":"2021_ScientificReports_Robinson.pdf","creator":"cchlebak","access_level":"open_access","content_type":"application/pdf","relation":"main_file","checksum":"f002ec22f609f58e1263b79e7f79601e","date_created":"2021-10-05T14:56:48Z","file_size":6970368,"file_id":"10091","success":1,"date_updated":"2021-10-05T14:56:48Z"}],"pmid":1,"date_updated":"2023-08-14T07:05:15Z","tmp":{"image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","short":"CC BY (4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode"},"article_processing_charge":"Yes","month":"09","date_published":"2021-09-28T00:00:00Z","publication_status":"published","abstract":[{"lang":"eng","text":"The extent to which women differ in the course of blood cell counts throughout pregnancy, and the importance of these changes to pregnancy outcomes has not been well defined. Here, we develop a series of statistical analyses of repeated measures data to reveal the degree to which women differ in the course of pregnancy, predict the changes that occur, and determine the importance of these changes for post-partum hemorrhage (PPH) which is one of the leading causes of maternal mortality. We present a prospective cohort of 4082 births recorded at the University Hospital, Lausanne, Switzerland between 2009 and 2014 where full labour records could be obtained, along with complete blood count data taken at hospital admission. We find significant differences, at a [Formula: see text] level, among women in how blood count values change through pregnancy for mean corpuscular hemoglobin, mean corpuscular volume, mean platelet volume, platelet count and red cell distribution width. We find evidence that almost all complete blood count values show trimester-specific associations with PPH. For example, high platelet count (OR 1.20, 95% CI 1.01-1.53), high mean platelet volume (OR 1.58, 95% CI 1.04-2.08), and high erythrocyte levels (OR 1.36, 95% CI 1.01-1.57) in trimester 1 increased PPH, but high values in trimester 3 decreased PPH risk (OR 0.85, 0.79, 0.67 respectively). We show that differences among women in the course of blood cell counts throughout pregnancy have an important role in shaping pregnancy outcome and tracking blood count value changes through pregnancy improves identification of women at increased risk of postpartum hemorrhage. This study provides greater understanding of the complex changes in blood count values that occur through pregnancy and provides indicators to guide the stratification of patients into risk groups."}],"department":[{"_id":"MaRo"}]}