---
_id: '14479'
abstract:
- lang: eng
text: 'In animals, parasitic infections impose significant fitness costs.1,2,3,4,5,6
Infected animals can alter their feeding behavior to resist infection,7,8,9,10,11,12
but parasites can manipulate animal foraging behavior to their own benefits.13,14,15,16
How nutrition influences host-parasite interactions is not well understood, as
studies have mainly focused on the host and less on the parasite.9,12,17,18,19,20,21,22,23
We used the nutritional geometry framework24 to investigate the role of amino
acids (AA) and carbohydrates (C) in a host-parasite system: the Argentine ant,
Linepithema humile, and the entomopathogenic fungus, Metarhizium brunneum. First,
using 18 diets varying in AA:C composition, we established that the fungus performed
best on the high-amino-acid diet 1:4. Second, we found that the fungus reached
this optimal diet when given various diet pairings, revealing its ability to cope
with nutritional challenges. Third, we showed that the optimal fungal diet reduced
the lifespan of healthy ants when compared with a high-carbohydrate diet but had
no effect on infected ants. Fourth, we revealed that infected ant colonies, given
a choice between the optimal fungal diet and a high-carbohydrate diet, chose the
optimal fungal diet, whereas healthy colonies avoided it. Lastly, by disentangling
fungal infection from host immune response, we demonstrated that infected ants
foraged on the optimal fungal diet in response to immune activation and not as
a result of parasite manipulation. Therefore, we revealed that infected ant colonies
chose a diet that is costly for survival in the long term but beneficial in the
short term—a form of collective self-medication.'
acknowledgement: We are sincerely grateful to the referees for their valuable comments
and suggestions, which helped us to improve the paper. We are thankful to Jorgen
Eilenberg and Nicolai V. Meyling for the fungal strain, to Simon Tragust, Abel Bernadou,
and Brian Lazarro for insightful discussions, to Iago Sanmartín-Villar, Léa Briard,
Céline Maitrel, and Nolwenn Rissen for their help with the experiments. Furthermore,
we thank Anna V. Grasse for help with the immune gene expression analyses. We thank
Sergio Ibarra for creating the graphical abstract. E.C. was supported by a Fyssen
Foundation grant and the Alexander von Humboldt Foundation. A.D. was supported by
the CNRS.
article_processing_charge: No
article_type: original
author:
- first_name: Eniko
full_name: Csata, Eniko
last_name: Csata
- first_name: Alfonso
full_name: Perez-Escudero, Alfonso
last_name: Perez-Escudero
- first_name: Emmanuel
full_name: Laury, Emmanuel
last_name: Laury
- first_name: Hanna
full_name: Leitner, Hanna
id: 8fc5c6f6-5903-11ec-abad-c83f046253e7
last_name: Leitner
- first_name: Gerard
full_name: Latil, Gerard
last_name: Latil
- first_name: Juerge
full_name: Heinze, Juerge
last_name: Heinze
- first_name: Stephen
full_name: Simpson, Stephen
last_name: Simpson
- first_name: Sylvia
full_name: Cremer, Sylvia
id: 2F64EC8C-F248-11E8-B48F-1D18A9856A87
last_name: Cremer
orcid: 0000-0002-2193-3868
- first_name: Audrey
full_name: Dussutour, Audrey
last_name: Dussutour
citation:
ama: Csata E, Perez-Escudero A, Laury E, et al. Fungal infection alters collective
nutritional intake of ant colonies. Current Biology. 2024;34(4):902-909.e6.
doi:10.1016/j.cub.2024.01.017
apa: Csata, E., Perez-Escudero, A., Laury, E., Leitner, H., Latil, G., Heinze, J.,
… Dussutour, A. (2024). Fungal infection alters collective nutritional intake
of ant colonies. Current Biology. Elsevier. https://doi.org/10.1016/j.cub.2024.01.017
chicago: Csata, Eniko, Alfonso Perez-Escudero, Emmanuel Laury, Hanna Leitner, Gerard
Latil, Juerge Heinze, Stephen Simpson, Sylvia Cremer, and Audrey Dussutour. “Fungal
Infection Alters Collective Nutritional Intake of Ant Colonies.” Current Biology.
Elsevier, 2024. https://doi.org/10.1016/j.cub.2024.01.017.
ieee: E. Csata et al., “Fungal infection alters collective nutritional intake
of ant colonies,” Current Biology, vol. 34, no. 4. Elsevier, p. 902–909.e6,
2024.
ista: Csata E, Perez-Escudero A, Laury E, Leitner H, Latil G, Heinze J, Simpson
S, Cremer S, Dussutour A. 2024. Fungal infection alters collective nutritional
intake of ant colonies. Current Biology. 34(4), 902–909.e6.
mla: Csata, Eniko, et al. “Fungal Infection Alters Collective Nutritional Intake
of Ant Colonies.” Current Biology, vol. 34, no. 4, Elsevier, 2024, p. 902–909.e6,
doi:10.1016/j.cub.2024.01.017.
short: E. Csata, A. Perez-Escudero, E. Laury, H. Leitner, G. Latil, J. Heinze, S.
Simpson, S. Cremer, A. Dussutour, Current Biology 34 (2024) 902–909.e6.
dataavailabilitystatement: no DAS
date_created: 2023-10-31T13:30:20Z
date_published: 2024-02-26T00:00:00Z
date_updated: 2026-03-18T11:15:21Z
day: '26'
department:
- _id: SyCr
doi: 10.1016/j.cub.2024.01.017
external_id:
pmid:
- '38307022'
intvolume: ' 34'
issue: '4'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://doi.org/10.1101/2023.10.26.564092
month: '02'
oa: 1
oa_version: Preprint
page: 902-909.e6
pmid: 1
publication: Current Biology
publication_identifier:
eissn:
- 1879-0445
issn:
- 0960-9822
issnl:
- 1234-5678
publication_status: published
publisher: Elsevier
quality_controlled: '1'
researchdata_availability: unclear
scopus_import: '1'
status: public
supplementarymaterial: yes
title: Fungal infection alters collective nutritional intake of ant colonies
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 34
year: '2024'
...
---
_id: '14478'
abstract:
- lang: eng
text: Entire chromosomes are typically only transmitted vertically from one generation
to the next. The horizontal transfer of such chromosomes has long been considered
improbable, yet gained recent support in several pathogenic fungi where it may
affect the fitness or host specificity. To date, it is unknown how these transfers
occur, how common they are and whether they can occur between different species.
In this study, we show multiple independent instances of horizontal transfers
of the same accessory chromosome between two distinct strains of the asexual entomopathogenic
fungusMetarhizium robertsiiduring experimental co-infection
of its insect host, the Argentine ant. Notably, only the one chromosome – but
no other – was transferred from the donor to the recipient strain. The recipient
strain, now harboring the accessory chromosome, exhibited a competitive advantage
under certain host conditions. By phylogenetic analysis we further demonstrate
that the same accessory chromosome was horizontally transferred in a natural environment
betweenM. robertsiiand another congeneric insect pathogen,M.
guizhouense. Hence horizontal chromosome transfer is not limited
to the observed frequent events within species during experimental infections
but also occurs naturally across species. The transferred accessory chromosome
contains genes that might be involved in its preferential horizontal transfer,
encoding putative histones and histone-modifying enzymes, but also putative virulence
factors that may support its establishment. Our study reveals that both intra-
and interspecies horizontal transfer of entire chromosomes is more frequent than
previously assumed, likely representing a not uncommon mechanism for gene exchange.Significance
StatementThe enormous success of bacterial pathogens has
been attributed to their ability to exchange genetic material between one another.
Similarly, in eukaryotes, horizontal transfer of genetic material allowed the
spread of virulence factors across species. The horizontal transfer of whole chromosomes
could be an important pathway for such exchange of genetic material, but little
is known about the origin of transferable chromosomes and how frequently they
are exchanged. Here, we show that the transfer of accessory chromosomes - chromosomes
that are non-essential but may provide fitness benefits - is common during fungal
co-infections and is even possible between distant pathogenic species, highlighting
the importance of horizontal gene transfer via chromosome transfer also for the
evolution and function of eukaryotic pathogens.
acknowledgement: We thank Bernhardt Steinwender, Jorgen Eilenberg and Nicolai V. Meyling
for the fungal strains. We further thank Chengshu Wang for providing the short sequencing
reads for M. guizhouense ARESF977 he used for his published genome assembly, and
Kristian Ullrich for help in the bioinformatics analysis for methylation pattern
in Nanopore reads, and the Vienna BioCenter and the Max Planck Society for the use
of their sequencing centers. We thank Barbara Milutinović and Hinrich Schulenburg
for discussion, and Tal Dagan and Jens Rolff for comments on a previous version
of the manuscript. Fig1 A was created with BioRender.com. This study received funding
by the European Research Council (ERC) under the European Union’s Horizon 2020 Research
and Innovation Programme (No. 771402; EPIDEMICSonCHIP) to S.C. and by the German
Research Foundation (DFG grant HA9263/1-1) to M.H.
article_processing_charge: No
author:
- first_name: Michael
full_name: Habig, Michael
last_name: Habig
- first_name: Anna V
full_name: Grasse, Anna V
id: 406F989C-F248-11E8-B48F-1D18A9856A87
last_name: Grasse
- first_name: Judith
full_name: Müller, Judith
last_name: Müller
- first_name: Eva H.
full_name: Stukenbrock, Eva H.
last_name: Stukenbrock
- first_name: Hanna
full_name: Leitner, Hanna
id: 8fc5c6f6-5903-11ec-abad-c83f046253e7
last_name: Leitner
- first_name: Sylvia
full_name: Cremer, Sylvia
id: 2F64EC8C-F248-11E8-B48F-1D18A9856A87
last_name: Cremer
orcid: 0000-0002-2193-3868
citation:
ama: Habig M, Grasse AV, Müller J, Stukenbrock EH, Leitner H, Cremer S. Frequent
horizontal chromosome transfer between asexual fungal insect pathogens. bioRxiv.
doi:10.1101/2023.09.18.558174
apa: Habig, M., Grasse, A. V., Müller, J., Stukenbrock, E. H., Leitner, H., &
Cremer, S. (n.d.). Frequent horizontal chromosome transfer between asexual fungal
insect pathogens. bioRxiv. https://doi.org/10.1101/2023.09.18.558174
chicago: Habig, Michael, Anna V Grasse, Judith Müller, Eva H. Stukenbrock, Hanna
Leitner, and Sylvia Cremer. “Frequent Horizontal Chromosome Transfer between Asexual
Fungal Insect Pathogens.” BioRxiv, n.d. https://doi.org/10.1101/2023.09.18.558174.
ieee: M. Habig, A. V. Grasse, J. Müller, E. H. Stukenbrock, H. Leitner, and S. Cremer,
“Frequent horizontal chromosome transfer between asexual fungal insect pathogens,”
bioRxiv. .
ista: Habig M, Grasse AV, Müller J, Stukenbrock EH, Leitner H, Cremer S. Frequent
horizontal chromosome transfer between asexual fungal insect pathogens. bioRxiv,
10.1101/2023.09.18.558174.
mla: Habig, Michael, et al. “Frequent Horizontal Chromosome Transfer between Asexual
Fungal Insect Pathogens.” BioRxiv, doi:10.1101/2023.09.18.558174.
short: M. Habig, A.V. Grasse, J. Müller, E.H. Stukenbrock, H. Leitner, S. Cremer,
BioRxiv (n.d.).
date_created: 2023-10-31T13:30:00Z
date_published: 2023-09-19T00:00:00Z
date_updated: 2023-11-07T11:20:54Z
day: '19'
department:
- _id: SyCr
doi: 10.1101/2023.09.18.558174
ec_funded: 1
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://doi.org/10.1101/2023.09.18.558174
month: '09'
oa: 1
oa_version: Preprint
project:
- _id: 2649B4DE-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '771402'
name: Epidemics in ant societies on a chip
publication: bioRxiv
publication_status: submitted
status: public
title: Frequent horizontal chromosome transfer between asexual fungal insect pathogens
type: preprint
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '2023'
...
---
_id: '13127'
abstract:
- lang: eng
text: Cooperative disease defense emerges as group-level collective behavior, yet
how group members make the underlying individual decisions is poorly understood.
Using garden ants and fungal pathogens as an experimental model, we derive the
rules governing individual ant grooming choices and show how they produce colony-level
hygiene. Time-resolved behavioral analysis, pathogen quantification, and probabilistic
modeling reveal that ants increase grooming and preferentially target highly-infectious
individuals when perceiving high pathogen load, but transiently suppress grooming
after having been groomed by nestmates. Ants thus react to both, the infectivity
of others and the social feedback they receive on their own contagiousness. While
inferred solely from momentary ant decisions, these behavioral rules quantitatively
predict hour-long experimental dynamics, and synergistically combine into efficient
colony-wide pathogen removal. Our analyses show that noisy individual decisions
based on only local, incomplete, yet dynamically-updated information on pathogen
threat and social feedback can lead to potent collective disease defense.
acknowledged_ssus:
- _id: LifeSc
acknowledgement: We thank Mike Bidochka for the fungal strains, the ISTA Social Immunity
Team for ant collection, Hanna Leitner for experimental and molecular support, Jennifer
Robb and Lukas Lindorfer for microscopy, and the LabSupport Facility at ISTA for
general laboratory support. We further thank Victor Mireles, Iain Couzin, Fabian
Theis and the Social Immunity Team for continued feedback throughout, and Michael
Sixt, Yuko Ulrich, Koos Boomsma, Erika Dawson, Megan Kutzer and Hinrich Schulenburg
for comments on the manuscript. This project has received funding from the European
Research Council (ERC) under the European Union’s Horizon 2020 research and innovation
program (Grant No. 771402; EPIDEMICSonCHIP) to SC, from the Scientific Grant Agency
of the Slovak Republic (Grant No. 1/0521/20) to KB, and the Human Frontier Science
Program (Grant No. RGP0065/2012) to GT.
article_number: '3232'
article_processing_charge: Yes
article_type: original
author:
- first_name: Barbara E
full_name: Casillas Perez, Barbara E
id: 351ED2AA-F248-11E8-B48F-1D18A9856A87
last_name: Casillas Perez
- first_name: Katarína
full_name: Bod'Ová, Katarína
id: 2BA24EA0-F248-11E8-B48F-1D18A9856A87
last_name: Bod'Ová
orcid: 0000-0002-7214-0171
- first_name: Anna V
full_name: Grasse, Anna V
id: 406F989C-F248-11E8-B48F-1D18A9856A87
last_name: Grasse
- first_name: Gašper
full_name: Tkačik, Gašper
id: 3D494DCA-F248-11E8-B48F-1D18A9856A87
last_name: Tkačik
orcid: 0000-0002-6699-1455
- first_name: Sylvia
full_name: Cremer, Sylvia
id: 2F64EC8C-F248-11E8-B48F-1D18A9856A87
last_name: Cremer
orcid: 0000-0002-2193-3868
citation:
ama: Casillas Perez BE, Bodova K, Grasse AV, Tkačik G, Cremer S. Dynamic pathogen
detection and social feedback shape collective hygiene in ants. Nature Communications.
2023;14. doi:10.1038/s41467-023-38947-y
apa: Casillas Perez, B. E., Bodova, K., Grasse, A. V., Tkačik, G., & Cremer,
S. (2023). Dynamic pathogen detection and social feedback shape collective hygiene
in ants. Nature Communications. Springer Nature. https://doi.org/10.1038/s41467-023-38947-y
chicago: Casillas Perez, Barbara E, Katarina Bodova, Anna V Grasse, Gašper Tkačik,
and Sylvia Cremer. “Dynamic Pathogen Detection and Social Feedback Shape Collective
Hygiene in Ants.” Nature Communications. Springer Nature, 2023. https://doi.org/10.1038/s41467-023-38947-y.
ieee: B. E. Casillas Perez, K. Bodova, A. V. Grasse, G. Tkačik, and S. Cremer, “Dynamic
pathogen detection and social feedback shape collective hygiene in ants,” Nature
Communications, vol. 14. Springer Nature, 2023.
ista: Casillas Perez BE, Bodova K, Grasse AV, Tkačik G, Cremer S. 2023. Dynamic
pathogen detection and social feedback shape collective hygiene in ants. Nature
Communications. 14, 3232.
mla: Casillas Perez, Barbara E., et al. “Dynamic Pathogen Detection and Social Feedback
Shape Collective Hygiene in Ants.” Nature Communications, vol. 14, 3232,
Springer Nature, 2023, doi:10.1038/s41467-023-38947-y.
short: B.E. Casillas Perez, K. Bodova, A.V. Grasse, G. Tkačik, S. Cremer, Nature
Communications 14 (2023).
date_created: 2023-06-11T22:00:40Z
date_published: 2023-06-03T00:00:00Z
date_updated: 2023-08-07T13:09:09Z
day: '03'
ddc:
- '570'
department:
- _id: SyCr
- _id: GaTk
doi: 10.1038/s41467-023-38947-y
ec_funded: 1
external_id:
isi:
- '001002562700005'
pmid:
- '37270641'
file:
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date_updated: 2023-06-13T08:05:46Z
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file_date_updated: 2023-06-13T08:05:46Z
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month: '06'
oa: 1
oa_version: Published Version
pmid: 1
project:
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call_identifier: H2020
grant_number: '771402'
name: Epidemics in ant societies on a chip
- _id: 255008E4-B435-11E9-9278-68D0E5697425
grant_number: RGP0065/2012
name: Information processing and computation in fish groups
publication: Nature Communications
publication_identifier:
eissn:
- 2041-1723
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
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record:
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relation: research_data
status: public
scopus_import: '1'
status: public
title: Dynamic pathogen detection and social feedback shape collective hygiene in
ants
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 14
year: '2023'
...
---
_id: '13984'
abstract:
- lang: eng
text: "Social insects fight disease using their individual immune systems and the
cooperative\r\nsanitary behaviors of colony members. These social defenses are
well explored against\r\nexternally-infecting pathogens, but little is known about
defense strategies against\r\ninternally-infecting pathogens, such as viruses.
Viruses are ubiquitous and in the last decades\r\nit has become evident that also
many ant species harbor viruses. We present one of the first\r\nstudies addressing
transmission dynamics and collective disease defenses against viruses in\r\nants
on a mechanistic level. I successfully established an experimental ant host –
viral\r\npathogen system as a model for the defense strategies used by social
insects against internal\r\npathogen infections, as outlined in the third chapter.
In particular, we studied how garden ants\r\n(Lasius neglectus) defend themselves
and their colonies against the generalist insect virus\r\nCrPV (cricket paralysis
virus). We chose microinjections of virus directly into the ants’\r\nhemolymph
because it allowed us to use a defined exposure dose. Here we show that this is
a\r\ngood model system, as the virus is replicating and thus infecting the host.
The ants mount a\r\nclear individual immune response against the viral infection,
which is characterized by a\r\nspecific siRNA pattern, namely siRNAs mapping against
the viral genome with a peak of 21\r\nand 22 bp long fragments. The onset of this
immune response is consistent with the timeline\r\nof viral replication that starts
already within two days post injection. The disease manifests in\r\ndecreased
survival over a course of two to three weeks.\r\nRegarding group living, we find
that infected ants show a strong individual immune response,\r\nbut that their
course of disease is little affected by nestmate presence, as described in chapter\r\nfour.
Hence, we do not find social immunity in the context of viral infections in ants.\r\nNestmates,
however, can contract the virus. Using Drosophila S2R+ cells in culture, we\r\nshowed
that 94 % of the nestmates contract active virus within four days of social contact
to\r\nan infected individual. Virus is transmitted in low doses, thus not causing
disease\r\ntransmission within the colony. While virus can be transmitted during
short direct contacts,\r\nwe also assume transmission from deceased ants and show
that the nestmates’ immune\r\nsystem gets activated after contracting a low viral
dose. We find considerable potential for\r\nindirect transmission via the nest
space. Virus is shed to the nest, where it stays viable for one\r\nweek and is
also picked up by other ants. Apart from that, we want to underline the potential\r\nof
ant poison as antiviral agent. We determined that ant poison successfully inactivates
CrPV\r\nin vitro. However, we found no evidence for effective poison use to sanitize
the nest space.\r\nOn the other hand, local application of ant poison by oral
poison uptake, which is part of the\r\nants prophylactic behavioral repertoire,
probably contributes to keeping the gut of each\r\nindividual sanitized. We hypothesize
that oral poison uptake might be the reason why we did\r\nnot find viable virus
in the trophallactic fluid.\r\nThe fifth chapter encompasses preliminary data
on potential social immunization. However,\r\nour experiments do not confirm an
actual survival benefit for the nestmates upon pathogen\r\nchallenge under the
given experimental settings. Nevertheless, we do not want to rule out the\r\npossibility
for nestmate immunization, but rather emphasize that considering different\r\nexperimental
timelines and viral doses would provide a multitude of options for follow-up\r\nexperiments.\r\nIn
conclusion, we find that prophylactic individual behaviors, such as oral poison
uptake,\r\nmight play a role in preventing viral disease transmission. Compared
to colony defense\r\nagainst external pathogens, internal pathogen infections
require a stronger component of\r\nindividual physiological immunity than behavioral
social immunity, yet could still lead to\r\ncollective protection."
acknowledged_ssus:
- _id: LifeSc
alternative_title:
- ISTA Thesis
article_processing_charge: No
author:
- first_name: Anna
full_name: Franschitz, Anna
id: 480826C8-F248-11E8-B48F-1D18A9856A87
last_name: Franschitz
citation:
ama: Franschitz A. Individual and social immunity against viral infections in ants.
2023. doi:10.15479/at:ista:13984
apa: Franschitz, A. (2023). Individual and social immunity against viral infections
in ants. Institute of Science and Technology Austria. https://doi.org/10.15479/at:ista:13984
chicago: Franschitz, Anna. “Individual and Social Immunity against Viral Infections
in Ants.” Institute of Science and Technology Austria, 2023. https://doi.org/10.15479/at:ista:13984.
ieee: A. Franschitz, “Individual and social immunity against viral infections in
ants,” Institute of Science and Technology Austria, 2023.
ista: Franschitz A. 2023. Individual and social immunity against viral infections
in ants. Institute of Science and Technology Austria.
mla: Franschitz, Anna. Individual and Social Immunity against Viral Infections
in Ants. Institute of Science and Technology Austria, 2023, doi:10.15479/at:ista:13984.
short: A. Franschitz, Individual and Social Immunity against Viral Infections in
Ants, Institute of Science and Technology Austria, 2023.
date_created: 2023-08-08T15:33:29Z
date_published: 2023-08-08T00:00:00Z
date_updated: 2024-03-01T15:25:17Z
day: '08'
ddc:
- '570'
- '577'
degree_awarded: PhD
department:
- _id: GradSch
- _id: SyCr
doi: 10.15479/at:ista:13984
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creator: cchlebak
date_created: 2024-03-01T08:56:06Z
date_updated: 2024-03-01T12:58:14Z
description: For printing purposes
file_id: '15044'
file_name: Print_Version_Franschitz_Anna_Thesis.pdf
file_size: 10416761
relation: other
title: Print Version
file_date_updated: 2024-03-01T12:58:14Z
has_accepted_license: '1'
language:
- iso: eng
month: '08'
oa_version: Published Version
page: '89'
publication_identifier:
isbn:
- 978-3-99078-034-3
issn:
- 2663 - 337X
publication_status: published
publisher: Institute of Science and Technology Austria
status: public
supervisor:
- first_name: Sylvia
full_name: Cremer, Sylvia
id: 2F64EC8C-F248-11E8-B48F-1D18A9856A87
last_name: Cremer
orcid: 0000-0002-2193-3868
title: Individual and social immunity against viral infections in ants
type: dissertation
user_id: 8b945eb4-e2f2-11eb-945a-df72226e66a9
year: '2023'
...
---
_id: '12469'
abstract:
- lang: eng
text: 'Hosts can carry many viruses in their bodies, but not all of them cause disease.
We studied ants as a social host to determine both their overall viral repertoire
and the subset of actively infecting viruses across natural populations of three
subfamilies: the Argentine ant (Linepithema humile, Dolichoderinae), the invasive
garden ant (Lasius neglectus, Formicinae) and the red ant (Myrmica rubra, Myrmicinae).
We used a dual sequencing strategy to reconstruct complete virus genomes by RNA-seq
and to simultaneously determine the small interfering RNAs (siRNAs) by small RNA
sequencing (sRNA-seq), which constitute the host antiviral RNAi immune response.
This approach led to the discovery of 41 novel viruses in ants and revealed a
host ant-specific RNAi response (21 vs. 22 nt siRNAs) in the different ant species.
The efficiency of the RNAi response (sRNA/RNA read count ratio) depended on the
virus and the respective ant species, but not its population. Overall, we found
the highest virus abundance and diversity per population in Li. humile, followed
by La. neglectus and M. rubra. Argentine ants also shared a high proportion of
viruses between populations, whilst overlap was nearly absent in M. rubra. Only
one of the 59 viruses was found to infect two of the ant species as hosts, revealing
high host-specificity in active infections. In contrast, six viruses actively
infected one ant species, but were found as contaminants only in the others. Disentangling
spillover of disease-causing infection from non-infecting contamination across
species is providing relevant information for disease ecology and ecosystem management.'
acknowledgement: "We thank D.J. Obbard for sharing the details of the dual RNA-seq/sRNA-seq
approach, S.\r\nMetzler and R. Ferrigato for the photographs (Figure 1), M. Konrad,
B. Casillas-Perez, C.D.\r\nPull and X. Espadaler for help with ant collection, and
the Social Immunity Team at IST\r\nAustria, in particular J. Robb, A. Franschitz,
E. Naderlinger, E. Dawson and B. Casillas-Perez\r\nfor support and comments on the
manuscript. The study was funded by the Austrian Science\r\nFund (FWF; M02076-B25
to MAF) and the Academy of Finland (343022 to LV). "
article_number: '1119002'
article_processing_charge: Yes (via OA deal)
article_type: original
author:
- first_name: Lumi
full_name: Viljakainen, Lumi
last_name: Viljakainen
- first_name: Matthias
full_name: Fürst, Matthias
id: 393B1196-F248-11E8-B48F-1D18A9856A87
last_name: Fürst
orcid: 0000-0002-3712-925X
- first_name: Anna V
full_name: Grasse, Anna V
id: 406F989C-F248-11E8-B48F-1D18A9856A87
last_name: Grasse
- first_name: Jaana
full_name: Jurvansuu, Jaana
last_name: Jurvansuu
- first_name: Jinook
full_name: Oh, Jinook
id: 403169A4-080F-11EA-9993-BF3F3DDC885E
last_name: Oh
orcid: 0000-0001-7425-2372
- first_name: Lassi
full_name: Tolonen, Lassi
last_name: Tolonen
- first_name: Thomas
full_name: Eder, Thomas
last_name: Eder
- first_name: Thomas
full_name: Rattei, Thomas
last_name: Rattei
- first_name: Sylvia
full_name: Cremer, Sylvia
id: 2F64EC8C-F248-11E8-B48F-1D18A9856A87
last_name: Cremer
orcid: 0000-0002-2193-3868
citation:
ama: Viljakainen L, Fürst M, Grasse AV, et al. Antiviral immune response reveals
host-specific virus infections in natural ant populations. Frontiers in Microbiology.
2023;14. doi:10.3389/fmicb.2023.1119002
apa: Viljakainen, L., Fürst, M., Grasse, A. V., Jurvansuu, J., Oh, J., Tolonen,
L., … Cremer, S. (2023). Antiviral immune response reveals host-specific virus
infections in natural ant populations. Frontiers in Microbiology. Frontiers.
https://doi.org/10.3389/fmicb.2023.1119002
chicago: Viljakainen, Lumi, Matthias Fürst, Anna V Grasse, Jaana Jurvansuu, Jinook
Oh, Lassi Tolonen, Thomas Eder, Thomas Rattei, and Sylvia Cremer. “Antiviral Immune
Response Reveals Host-Specific Virus Infections in Natural Ant Populations.” Frontiers
in Microbiology. Frontiers, 2023. https://doi.org/10.3389/fmicb.2023.1119002.
ieee: L. Viljakainen et al., “Antiviral immune response reveals host-specific
virus infections in natural ant populations,” Frontiers in Microbiology,
vol. 14. Frontiers, 2023.
ista: Viljakainen L, Fürst M, Grasse AV, Jurvansuu J, Oh J, Tolonen L, Eder T, Rattei
T, Cremer S. 2023. Antiviral immune response reveals host-specific virus infections
in natural ant populations. Frontiers in Microbiology. 14, 1119002.
mla: Viljakainen, Lumi, et al. “Antiviral Immune Response Reveals Host-Specific
Virus Infections in Natural Ant Populations.” Frontiers in Microbiology,
vol. 14, 1119002, Frontiers, 2023, doi:10.3389/fmicb.2023.1119002.
short: L. Viljakainen, M. Fürst, A.V. Grasse, J. Jurvansuu, J. Oh, L. Tolonen, T.
Eder, T. Rattei, S. Cremer, Frontiers in Microbiology 14 (2023).
date_created: 2023-01-31T08:13:40Z
date_published: 2023-03-16T00:00:00Z
date_updated: 2023-08-01T12:39:58Z
day: '16'
ddc:
- '570'
department:
- _id: SyCr
doi: 10.3389/fmicb.2023.1119002
external_id:
isi:
- '000961542100001'
pmid:
- 'PPR559293 '
file:
- access_level: open_access
checksum: cd52292963acce1111634d9fac08c699
content_type: application/pdf
creator: dernst
date_created: 2023-04-17T07:49:09Z
date_updated: 2023-04-17T07:49:09Z
file_id: '12843'
file_name: 2023_FrontMicrobiology_Viljakainen.pdf
file_size: 4866332
relation: main_file
success: 1
file_date_updated: 2023-04-17T07:49:09Z
has_accepted_license: '1'
intvolume: ' 14'
isi: 1
language:
- iso: eng
month: '03'
oa: 1
oa_version: Published Version
pmid: 1
project:
- _id: 25DF61D8-B435-11E9-9278-68D0E5697425
call_identifier: FWF
grant_number: M02076
name: Viral pathogens and social immunity in ants
publication: Frontiers in Microbiology
publication_identifier:
eissn:
- 1664-302X
publication_status: published
publisher: Frontiers
quality_controlled: '1'
scopus_import: '1'
status: public
title: Antiviral immune response reveals host-specific virus infections in natural
ant populations
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 14
year: '2023'
...
---
_id: '12543'
abstract:
- lang: eng
text: Treating sick group members is a hallmark of collective disease defence in
vertebrates and invertebrates alike. Despite substantial effects on pathogen fitness
and epidemiology, it is still largely unknown how pathogens react to the selection
pressure imposed by care intervention. Using social insects and pathogenic fungi,
we here performed a serial passage experiment in the presence or absence of colony
members, which provide social immunity by grooming off infectious spores from
exposed individuals. We found specific effects on pathogen diversity, virulence
and transmission. Under selection of social immunity, pathogens invested into
higher spore production, but spores were less virulent. Notably, they also elicited
a lower grooming response in colony members, compared with spores from the individual
host selection lines. Chemical spore analysis suggested that the spores from social
selection lines escaped the caregivers’ detection by containing lower levels of
ergosterol, a key fungal membrane component. Experimental application of chemically
pure ergosterol indeed induced sanitary grooming, supporting its role as a microbe-associated
cue triggering host social immunity against fungal pathogens. By reducing this
detection cue, pathogens were able to evade the otherwise very effective collective
disease defences of their social hosts.
acknowledged_ssus:
- _id: LifeSc
acknowledgement: We thank B. M. Steinwender, N. V. Meyling and J. Eilenberg for the
fungal strains; J. Anaya-Rojas for statistical advice; the Social Immunity team
at ISTA for ant collection and experimental help, in particular H. Leitner, and
the ISTA Lab Support Facility for general laboratory support; D. Ebert, H. Schulenburg
and J. Heinze for continued project discussion; and M. Sixt, R. Roemhild and the
Social Immunity team for comments on the manuscript. The study was funded by the
German Research Foundation (CR118/3-1) within the Framework of the Priority Program
SPP 1399, and the European Research Council (ERC) under the European Union’s Horizon
2020 Research and Innovation Programme (No. 771402; EPIDEMICSonCHIP), both to S.C.
article_processing_charge: No
article_type: original
author:
- first_name: Miriam
full_name: Stock, Miriam
id: 42462816-F248-11E8-B48F-1D18A9856A87
last_name: Stock
- first_name: Barbara
full_name: Milutinovic, Barbara
id: 2CDC32B8-F248-11E8-B48F-1D18A9856A87
last_name: Milutinovic
orcid: 0000-0002-8214-4758
- first_name: Michaela
full_name: Hönigsberger, Michaela
id: 953894f3-25bd-11ec-8556-f70a9d38ef60
last_name: Hönigsberger
- first_name: Anna V
full_name: Grasse, Anna V
id: 406F989C-F248-11E8-B48F-1D18A9856A87
last_name: Grasse
- first_name: Florian
full_name: Wiesenhofer, Florian
id: 39523C54-F248-11E8-B48F-1D18A9856A87
last_name: Wiesenhofer
- first_name: Niklas
full_name: Kampleitner, Niklas
id: 2AC57FAC-F248-11E8-B48F-1D18A9856A87
last_name: Kampleitner
- first_name: Madhumitha
full_name: Narasimhan, Madhumitha
id: 44BF24D0-F248-11E8-B48F-1D18A9856A87
last_name: Narasimhan
orcid: 0000-0002-8600-0671
- first_name: Thomas
full_name: Schmitt, Thomas
last_name: Schmitt
- first_name: Sylvia
full_name: Cremer, Sylvia
id: 2F64EC8C-F248-11E8-B48F-1D18A9856A87
last_name: Cremer
orcid: 0000-0002-2193-3868
citation:
ama: Stock M, Milutinovic B, Hönigsberger M, et al. Pathogen evasion of social immunity.
Nature Ecology and Evolution. 2023;7:450-460. doi:10.1038/s41559-023-01981-6
apa: Stock, M., Milutinovic, B., Hönigsberger, M., Grasse, A. V., Wiesenhofer, F.,
Kampleitner, N., … Cremer, S. (2023). Pathogen evasion of social immunity. Nature
Ecology and Evolution. Springer Nature. https://doi.org/10.1038/s41559-023-01981-6
chicago: Stock, Miriam, Barbara Milutinovic, Michaela Hönigsberger, Anna V Grasse,
Florian Wiesenhofer, Niklas Kampleitner, Madhumitha Narasimhan, Thomas Schmitt,
and Sylvia Cremer. “Pathogen Evasion of Social Immunity.” Nature Ecology and
Evolution. Springer Nature, 2023. https://doi.org/10.1038/s41559-023-01981-6.
ieee: M. Stock et al., “Pathogen evasion of social immunity,” Nature Ecology
and Evolution, vol. 7. Springer Nature, pp. 450–460, 2023.
ista: Stock M, Milutinovic B, Hönigsberger M, Grasse AV, Wiesenhofer F, Kampleitner
N, Narasimhan M, Schmitt T, Cremer S. 2023. Pathogen evasion of social immunity.
Nature Ecology and Evolution. 7, 450–460.
mla: Stock, Miriam, et al. “Pathogen Evasion of Social Immunity.” Nature Ecology
and Evolution, vol. 7, Springer Nature, 2023, pp. 450–60, doi:10.1038/s41559-023-01981-6.
short: M. Stock, B. Milutinovic, M. Hönigsberger, A.V. Grasse, F. Wiesenhofer, N.
Kampleitner, M. Narasimhan, T. Schmitt, S. Cremer, Nature Ecology and Evolution
7 (2023) 450–460.
date_created: 2023-02-12T23:00:59Z
date_published: 2023-03-01T00:00:00Z
date_updated: 2023-08-16T11:55:48Z
day: '01'
ddc:
- '570'
department:
- _id: SyCr
- _id: LifeSc
- _id: JiFr
doi: 10.1038/s41559-023-01981-6
ec_funded: 1
external_id:
isi:
- '000924572800001'
pmid:
- '36732670'
file:
- access_level: open_access
checksum: 8244f4650a0e7aeea488d1bcd4a31702
content_type: application/pdf
creator: dernst
date_created: 2023-08-16T11:54:59Z
date_updated: 2023-08-16T11:54:59Z
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file_date_updated: 2023-08-16T11:54:59Z
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intvolume: ' 7'
isi: 1
language:
- iso: eng
month: '03'
oa: 1
oa_version: Published Version
page: 450-460
pmid: 1
project:
- _id: 2649B4DE-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '771402'
name: Epidemics in ant societies on a chip
- _id: 25DAF0B2-B435-11E9-9278-68D0E5697425
grant_number: CR-118/3-1
name: Host-Parasite Coevolution
publication: Nature Ecology and Evolution
publication_identifier:
eissn:
- 2397-334X
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
related_material:
link:
- description: News on ISTA website
relation: press_release
url: https://ista.ac.at/en/news/how-sneaky-germs-hide-from-ants/
scopus_import: '1'
status: public
title: Pathogen evasion of social immunity
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 7
year: '2023'
...
---
_id: '12693'
abstract:
- lang: eng
text: See Readme File for further information.
article_processing_charge: No
author:
- first_name: Sylvia
full_name: Cremer, Sylvia
id: 2F64EC8C-F248-11E8-B48F-1D18A9856A87
last_name: Cremer
orcid: 0000-0002-2193-3868
citation:
ama: 'Cremer S. Source data for Metzler et al, 2023: Trade-offs between immunity
and competitive ability in fighting ant males . 2023. doi:10.15479/AT:ISTA:12693'
apa: 'Cremer, S. (2023). Source data for Metzler et al, 2023: Trade-offs between
immunity and competitive ability in fighting ant males . Institute of Science
and Technology Austria. https://doi.org/10.15479/AT:ISTA:12693'
chicago: 'Cremer, Sylvia. “Source Data for Metzler et Al, 2023: Trade-Offs between
Immunity and Competitive Ability in Fighting Ant Males .” Institute of Science
and Technology Austria, 2023. https://doi.org/10.15479/AT:ISTA:12693.'
ieee: 'S. Cremer, “Source data for Metzler et al, 2023: Trade-offs between immunity
and competitive ability in fighting ant males .” Institute of Science and Technology
Austria, 2023.'
ista: 'Cremer S. 2023. Source data for Metzler et al, 2023: Trade-offs between immunity
and competitive ability in fighting ant males , Institute of Science and Technology
Austria, 10.15479/AT:ISTA:12693.'
mla: 'Cremer, Sylvia. Source Data for Metzler et Al, 2023: Trade-Offs between
Immunity and Competitive Ability in Fighting Ant Males . Institute of Science
and Technology Austria, 2023, doi:10.15479/AT:ISTA:12693.'
short: S. Cremer, (2023).
contributor:
- contributor_type: data_collector
first_name: Sina
id: 48204546-F248-11E8-B48F-1D18A9856A87
last_name: Metzler
- contributor_type: data_collector
first_name: Jessica
id: 21516227-15aa-11ec-9fb2-c6e8ffc155d3
last_name: Kirchner
- contributor_type: data_collector
first_name: Anna V
id: 406F989C-F248-11E8-B48F-1D18A9856A87
last_name: Grasse
date_created: 2023-02-28T06:38:37Z
date_published: 2023-02-28T00:00:00Z
date_updated: 2023-12-13T11:13:13Z
day: '28'
ddc:
- '570'
department:
- _id: SyCr
doi: 10.15479/AT:ISTA:12693
file:
- access_level: open_access
checksum: c1565d655ca05601acfd84e0d12b8563
content_type: application/pdf
creator: scremer
date_created: 2023-02-28T06:34:08Z
date_updated: 2023-02-28T06:34:08Z
file_id: '12694'
file_name: Metzler_ReadMe.pdf
file_size: 77070
relation: main_file
success: 1
- access_level: open_access
checksum: 75c4c4948563d6261cb7548f80d909f1
content_type: application/vnd.openxmlformats-officedocument.spreadsheetml.sheet
creator: scremer
date_created: 2023-02-28T06:34:12Z
date_updated: 2023-02-28T06:34:12Z
file_id: '12695'
file_name: Metzler_RepositoryData.xlsx
file_size: 88001
relation: main_file
success: 1
file_date_updated: 2023-02-28T06:34:12Z
has_accepted_license: '1'
license: https://creativecommons.org/licenses/by-nc/4.0/
month: '02'
oa: 1
oa_version: Published Version
publisher: Institute of Science and Technology Austria
related_material:
record:
- id: '12696'
relation: used_in_publication
status: public
status: public
title: 'Source data for Metzler et al, 2023: Trade-offs between immunity and competitive
ability in fighting ant males '
tmp:
image: /images/cc_by_nc.png
legal_code_url: https://creativecommons.org/licenses/by-nc/4.0/legalcode
name: Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0)
short: CC BY-NC (4.0)
type: research_data
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '2023'
...
---
_id: '12696'
abstract:
- lang: eng
text: "Background: Fighting disease while fighting rivals exposes males to constraints
and tradeoffs during male-male competition. We here tested how both the stage
and intensity of infection with the fungal pathogen Metarhizium robertsii interfered
with fighting success in Cardiocondyla obscurior ant males. Males of this species
have evolved long lifespans during which they can gain many matings with the young
queens of the colony, if successful in male-male competition. Since male fights
occur inside the colony, the outcome of male-male competition can further be biased
by interference of the colony’s worker force.\r\nResults: We found that severe,
but not yet mild, infection strongly impaired male fighting success. In late-stage
infection, this could be attributed to worker aggression directed towards the
infected rather than the healthy male and an already very high male morbidity
even in the absence of fighting. Shortly after pathogen exposure, however, male
mortality was particularly increased during combat. Since these males mounted
a strong immune response, their reduced fighting success suggests a trade-off
between immune investment and competitive ability already early in the infection.
Even if the males themselves showed no difference in the number of attacks they
raised against their healthy rivals across infection stages and levels, severely
infected males were thus losing in male-male competition from an early stage of
infection on.\r\nConclusions: Males of the ant C. obscurior have evolved high
immune investment, triggering an effective immune response very fast after fungal
exposure. This allows them to cope with mild pathogen exposures without cost to
their success in male-male competition, and hence to gain multiple mating opportunities
with the emerging virgin queens of the colony. Under severe infection, however,
they are weak fighters and rarely survive a combat already at early infection
when raising an immune response, as well as at progressed infection, when they
are morbid and preferentially targeted by worker aggression. Workers thereby remove
males that pose a future disease threat by biasing male-male competition. Our
study thus revealed a novel social immunity mechanism how social insect workers
protect the colony against disease risk."
acknowledged_ssus:
- _id: LifeSc
acknowledgement: "We are thankful to Mike Bidochka for the fungal strain, Lukas Schrader
for sharing the C. obscurior genome data for primer development, the Lab Support
Facility of ISTA for general laboratory support and help with the permit approval
procedures, and the Finca El Quinto for letting us collect ants on their property.
We thank the Social Immunity Team at ISTA for help with ant collection and experimental
help, in particular Elina Hanhimäki and Marta Gorecka for behavioural observation,
and Elisabeth Naderlinger for spore load PCRs. We further thank the Social Immunity
Team and Jürgen Heinze for continued discussion and comments on the manuscript.\r\nOpen
access funding provided by Institute of Science and Technology Austria (ISTA). This
project received funding from the European Research Council (ERC) under the European
Union’s Horizon 2020 research and innovation programme (grant agreement No 771402
to SC). "
article_number: '37'
article_processing_charge: Yes
article_type: original
author:
- first_name: Sina
full_name: Metzler, Sina
id: 48204546-F248-11E8-B48F-1D18A9856A87
last_name: Metzler
orcid: 0000-0002-9547-2494
- first_name: Jessica
full_name: Kirchner, Jessica
id: 21516227-15aa-11ec-9fb2-c6e8ffc155d3
last_name: Kirchner
- first_name: Anna V
full_name: Grasse, Anna V
id: 406F989C-F248-11E8-B48F-1D18A9856A87
last_name: Grasse
- first_name: Sylvia
full_name: Cremer, Sylvia
id: 2F64EC8C-F248-11E8-B48F-1D18A9856A87
last_name: Cremer
orcid: 0000-0002-2193-3868
citation:
ama: Metzler S, Kirchner J, Grasse AV, Cremer S. Trade-offs between immunity and
competitive ability in fighting ant males. BMC Ecology and Evolution. 2023;23.
doi:10.1186/s12862-023-02137-7
apa: Metzler, S., Kirchner, J., Grasse, A. V., & Cremer, S. (2023). Trade-offs
between immunity and competitive ability in fighting ant males. BMC Ecology
and Evolution. Springer Nature. https://doi.org/10.1186/s12862-023-02137-7
chicago: Metzler, Sina, Jessica Kirchner, Anna V Grasse, and Sylvia Cremer. “Trade-Offs
between Immunity and Competitive Ability in Fighting Ant Males.” BMC Ecology
and Evolution. Springer Nature, 2023. https://doi.org/10.1186/s12862-023-02137-7.
ieee: S. Metzler, J. Kirchner, A. V. Grasse, and S. Cremer, “Trade-offs between
immunity and competitive ability in fighting ant males,” BMC Ecology and Evolution,
vol. 23. Springer Nature, 2023.
ista: Metzler S, Kirchner J, Grasse AV, Cremer S. 2023. Trade-offs between immunity
and competitive ability in fighting ant males. BMC Ecology and Evolution. 23,
37.
mla: Metzler, Sina, et al. “Trade-Offs between Immunity and Competitive Ability
in Fighting Ant Males.” BMC Ecology and Evolution, vol. 23, 37, Springer
Nature, 2023, doi:10.1186/s12862-023-02137-7.
short: S. Metzler, J. Kirchner, A.V. Grasse, S. Cremer, BMC Ecology and Evolution
23 (2023).
date_created: 2023-02-28T07:38:17Z
date_published: 2023-08-07T00:00:00Z
date_updated: 2023-12-13T11:13:14Z
day: '07'
ddc:
- '570'
department:
- _id: SyCr
doi: 10.1186/s12862-023-02137-7
ec_funded: 1
external_id:
isi:
- '001042643600002'
pmid:
- '37550612'
file:
- access_level: open_access
checksum: 95966dc7d242d2c85bdd4fe14233dbd8
content_type: application/pdf
creator: dernst
date_created: 2023-08-14T07:51:47Z
date_updated: 2023-08-14T07:51:47Z
file_id: '14048'
file_name: 2023_BMCEcology_Metzler.pdf
file_size: 2004276
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file_date_updated: 2023-08-14T07:51:47Z
has_accepted_license: '1'
intvolume: ' 23'
isi: 1
language:
- iso: eng
month: '08'
oa: 1
oa_version: Published Version
pmid: 1
project:
- _id: 2649B4DE-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '771402'
name: Epidemics in ant societies on a chip
publication: BMC Ecology and Evolution
publication_identifier:
issn:
- 2730-7182
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
related_material:
record:
- id: '12693'
relation: research_data
status: public
scopus_import: '1'
status: public
title: Trade-offs between immunity and competitive ability in fighting ant males
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 23
year: '2023'
...
---
_id: '12765'
abstract:
- lang: eng
text: "Animals exhibit a variety of behavioural defences against socially transmitted
parasites. These defences evolved to increase host fitness by avoiding, resisting
or tolerating infection.\r\nBecause they can occur in both infected individuals
and their uninfected social partners, these defences often have important consequences
for the social group.\r\nHere, we discuss the evolution and ecology of anti-parasite
behavioural defences across a taxonomically wide social spectrum, considering
colonial groups, stable groups, transitional groups and solitary animals.\r\nWe
discuss avoidance, resistance and tolerance behaviours across these social group
structures, identifying how social complexity, group composition and interdependent
social relationships may contribute to the expression and evolution of behavioural
strategies.\r\nFinally, we outline avenues for further investigation such as approaches
to quantify group-level responses, and the connection of the physiological and
behavioural response to parasites in different social contexts."
article_processing_charge: No
article_type: review
author:
- first_name: Sebastian
full_name: Stockmaier, Sebastian
last_name: Stockmaier
- first_name: Yuko
full_name: Ulrich, Yuko
last_name: Ulrich
- first_name: Gregory F.
full_name: Albery, Gregory F.
last_name: Albery
- first_name: Sylvia
full_name: Cremer, Sylvia
id: 2F64EC8C-F248-11E8-B48F-1D18A9856A87
last_name: Cremer
orcid: 0000-0002-2193-3868
- first_name: Patricia C.
full_name: Lopes, Patricia C.
last_name: Lopes
citation:
ama: Stockmaier S, Ulrich Y, Albery GF, Cremer S, Lopes PC. Behavioural defences
against parasites across host social structures. Functional Ecology. 2023;37(4):809-820.
doi:10.1111/1365-2435.14310
apa: Stockmaier, S., Ulrich, Y., Albery, G. F., Cremer, S., & Lopes, P. C. (2023).
Behavioural defences against parasites across host social structures. Functional
Ecology. British Ecological Society. https://doi.org/10.1111/1365-2435.14310
chicago: Stockmaier, Sebastian, Yuko Ulrich, Gregory F. Albery, Sylvia Cremer, and
Patricia C. Lopes. “Behavioural Defences against Parasites across Host Social
Structures.” Functional Ecology. British Ecological Society, 2023. https://doi.org/10.1111/1365-2435.14310.
ieee: S. Stockmaier, Y. Ulrich, G. F. Albery, S. Cremer, and P. C. Lopes, “Behavioural
defences against parasites across host social structures,” Functional Ecology,
vol. 37, no. 4. British Ecological Society, pp. 809–820, 2023.
ista: Stockmaier S, Ulrich Y, Albery GF, Cremer S, Lopes PC. 2023. Behavioural defences
against parasites across host social structures. Functional Ecology. 37(4), 809–820.
mla: Stockmaier, Sebastian, et al. “Behavioural Defences against Parasites across
Host Social Structures.” Functional Ecology, vol. 37, no. 4, British Ecological
Society, 2023, pp. 809–20, doi:10.1111/1365-2435.14310.
short: S. Stockmaier, Y. Ulrich, G.F. Albery, S. Cremer, P.C. Lopes, Functional
Ecology 37 (2023) 809–820.
date_created: 2023-03-26T22:01:09Z
date_published: 2023-04-01T00:00:00Z
date_updated: 2023-10-04T11:50:15Z
day: '01'
department:
- _id: SyCr
doi: 10.1111/1365-2435.14310
external_id:
isi:
- '000948940500001'
intvolume: ' 37'
isi: 1
issue: '4'
language:
- iso: eng
month: '04'
oa_version: None
page: 809-820
publication: Functional Ecology
publication_identifier:
eissn:
- 1365-2435
issn:
- 0269-8463
publication_status: published
publisher: British Ecological Society
quality_controlled: '1'
scopus_import: '1'
status: public
title: Behavioural defences against parasites across host social structures
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 37
year: '2023'
...
---
_id: '12945'
abstract:
- lang: eng
text: "basic data for use in code for experimental data analysis for manuscript
under revision: \r\nDynamic pathogen detection and social feedback shape collective
hygiene in ants\r\nCasillas-Pérez B, Boďová K, Grasse AV, Tkačik G, Cremer S"
acknowledged_ssus:
- _id: LifeSc
acknowledgement: This project has received funding from the European Research Council
(ERC) under the European Union’s Horizon 2020 research and innovation programme
(Grant No. 771402; EPIDEMICSonCHIP) to SC, from the Scientific Grant Agency of the
Slovak Republic (Grant No. 1/0521/20) to KB, and the Human Frontier Science Program
(Grant No. RGP0065/2012) to GT.
article_processing_charge: No
author:
- first_name: Sylvia
full_name: Cremer, Sylvia
id: 2F64EC8C-F248-11E8-B48F-1D18A9856A87
last_name: Cremer
orcid: 0000-0002-2193-3868
citation:
ama: 'Cremer S. Data from: “Dynamic pathogen detection and social feedback shape
collective hygiene in ants” . 2023. doi:10.15479/AT:ISTA:12945'
apa: 'Cremer, S. (2023). Data from: “Dynamic pathogen detection and social feedback
shape collective hygiene in ants” . Institute of Science and Technology Austria.
https://doi.org/10.15479/AT:ISTA:12945'
chicago: 'Cremer, Sylvia. “Data from: ‘Dynamic Pathogen Detection and Social Feedback
Shape Collective Hygiene in Ants’ .” Institute of Science and Technology Austria,
2023. https://doi.org/10.15479/AT:ISTA:12945.'
ieee: 'S. Cremer, “Data from: ‘Dynamic pathogen detection and social feedback shape
collective hygiene in ants’ .” Institute of Science and Technology Austria, 2023.'
ista: 'Cremer S. 2023. Data from: ‘Dynamic pathogen detection and social feedback
shape collective hygiene in ants’ , Institute of Science and Technology Austria,
10.15479/AT:ISTA:12945.'
mla: 'Cremer, Sylvia. Data from: “Dynamic Pathogen Detection and Social Feedback
Shape Collective Hygiene in Ants” . Institute of Science and Technology Austria,
2023, doi:10.15479/AT:ISTA:12945.'
short: S. Cremer, (2023).
contributor:
- contributor_type: data_collector
first_name: Barbara E
id: 351ED2AA-F248-11E8-B48F-1D18A9856A87
last_name: Casillas Perez
- contributor_type: data_collector
first_name: Anna V
id: 406F989C-F248-11E8-B48F-1D18A9856A87
last_name: Grasse
- contributor_type: researcher
first_name: Katarina
last_name: Bodova
- contributor_type: supervisor
first_name: Gašper
id: 3D494DCA-F248-11E8-B48F-1D18A9856A87
last_name: Tkačik
orcid: 0000-0002-6699-1455
date_created: 2023-05-11T21:35:17Z
date_published: 2023-05-12T00:00:00Z
date_updated: 2023-08-07T13:09:09Z
day: '12'
ddc:
- '570'
department:
- _id: SyCr
doi: 10.15479/AT:ISTA:12945
file:
- access_level: open_access
checksum: 3eadf17fd59ad8c98bf10bf63061863c
content_type: application/zip
creator: scremer
date_created: 2023-05-12T08:04:04Z
date_updated: 2023-05-12T08:04:04Z
file_id: '12947'
file_name: Experimental_data.zip
file_size: 3414674
relation: main_file
success: 1
- access_level: open_access
checksum: 1b5e8e01a0989154a76b44e6d8d68f89
content_type: application/octet-stream
creator: scremer
date_created: 2023-05-12T08:04:08Z
date_updated: 2023-05-12T08:04:08Z
file_id: '12948'
file_name: README_Experimental_Data.md
file_size: 2113
relation: main_file
success: 1
file_date_updated: 2023-05-12T08:04:08Z
has_accepted_license: '1'
keyword:
- collective behavior
- host-pathogen interactions
- social immunity
- epidemiology
- social insects
- probabilistic modeling
month: '05'
oa: 1
oa_version: None
publisher: Institute of Science and Technology Austria
related_material:
record:
- id: '13127'
relation: used_in_publication
status: public
status: public
title: 'Data from: "Dynamic pathogen detection and social feedback shape collective
hygiene in ants" '
tmp:
image: /images/cc_by_nc.png
legal_code_url: https://creativecommons.org/licenses/by-nc/4.0/legalcode
name: Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0)
short: CC BY-NC (4.0)
type: research_data
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '2023'
...
---
_id: '12961'
abstract:
- lang: eng
text: 'Two notes separated by a doubling in frequency sound similar to humans. This
“octave equivalence” is critical to perception and production of music and speech
and occurs early in human development. Because it also occurs cross-culturally,
a biological basis of octave equivalence has been hypothesized. Members of our
team previousy suggested four human traits are at the root of this phenomenon:
(1) vocal learning, (2) clear octave information in vocal harmonics, (3) differing
vocal ranges, and (4) vocalizing together. Using cross-species studies, we can
test how relevant these respective traits are, while controlling for enculturation
effects and addressing questions of phylogeny. Common marmosets possess forms
of three of the four traits, lacking differing vocal ranges. We tested 11 common
marmosets by adapting an established head-turning paradigm, creating a parallel
test to an important infant study. Unlike human infants, marmosets responded similarly
to tones shifted by an octave or other intervals. Because previous studies with
the same head-turning paradigm produced differential results to discernable acoustic
stimuli in common marmosets, our results suggest that marmosets do not perceive
octave equivalence. Our work suggests differing vocal ranges between adults and
children and men and women and the way they are used in singing together may be
critical to the development of octave equivalence.'
acknowledgement: We thank Prof. Dr. Thomas Bugnyar for supporting the study and financing
the marmoset laboratory, and Alexandra Bohmann and the animal keeping team for their
care. Vedrana Šlipogor was funded by University of South Bohemia postdoctoral fellowship.
article_number: e13395
article_processing_charge: No
article_type: original
author:
- first_name: Bernhard
full_name: Wagner, Bernhard
last_name: Wagner
- first_name: Vedrana
full_name: Šlipogor, Vedrana
last_name: Šlipogor
- first_name: Jinook
full_name: Oh, Jinook
id: 403169A4-080F-11EA-9993-BF3F3DDC885E
last_name: Oh
orcid: 0000-0001-7425-2372
- first_name: Marion
full_name: Varga, Marion
last_name: Varga
- first_name: Marisa
full_name: Hoeschele, Marisa
last_name: Hoeschele
citation:
ama: Wagner B, Šlipogor V, Oh J, Varga M, Hoeschele M. A comparison between common
marmosets (Callithrix jacchus) and human infants sheds light on traits proposed
to be at the root of human octave equivalence. Developmental Science. 2023;26(5).
doi:10.1111/desc.13395
apa: Wagner, B., Šlipogor, V., Oh, J., Varga, M., & Hoeschele, M. (2023). A
comparison between common marmosets (Callithrix jacchus) and human infants sheds
light on traits proposed to be at the root of human octave equivalence. Developmental
Science. Wiley. https://doi.org/10.1111/desc.13395
chicago: Wagner, Bernhard, Vedrana Šlipogor, Jinook Oh, Marion Varga, and Marisa
Hoeschele. “A Comparison between Common Marmosets (Callithrix Jacchus) and Human
Infants Sheds Light on Traits Proposed to Be at the Root of Human Octave Equivalence.”
Developmental Science. Wiley, 2023. https://doi.org/10.1111/desc.13395.
ieee: B. Wagner, V. Šlipogor, J. Oh, M. Varga, and M. Hoeschele, “A comparison between
common marmosets (Callithrix jacchus) and human infants sheds light on traits
proposed to be at the root of human octave equivalence,” Developmental Science,
vol. 26, no. 5. Wiley, 2023.
ista: Wagner B, Šlipogor V, Oh J, Varga M, Hoeschele M. 2023. A comparison between
common marmosets (Callithrix jacchus) and human infants sheds light on traits
proposed to be at the root of human octave equivalence. Developmental Science.
26(5), e13395.
mla: Wagner, Bernhard, et al. “A Comparison between Common Marmosets (Callithrix
Jacchus) and Human Infants Sheds Light on Traits Proposed to Be at the Root of
Human Octave Equivalence.” Developmental Science, vol. 26, no. 5, e13395,
Wiley, 2023, doi:10.1111/desc.13395.
short: B. Wagner, V. Šlipogor, J. Oh, M. Varga, M. Hoeschele, Developmental Science
26 (2023).
date_created: 2023-05-14T22:01:00Z
date_published: 2023-09-01T00:00:00Z
date_updated: 2023-10-04T11:37:33Z
day: '01'
department:
- _id: SyCr
doi: 10.1111/desc.13395
external_id:
pmid:
- '37101383'
intvolume: ' 26'
issue: '5'
language:
- iso: eng
month: '09'
oa_version: None
pmid: 1
publication: Developmental Science
publication_identifier:
eissn:
- 1467-7687
issn:
- 1363-755X
publication_status: published
publisher: Wiley
quality_controlled: '1'
scopus_import: '1'
status: public
title: A comparison between common marmosets (Callithrix jacchus) and human infants
sheds light on traits proposed to be at the root of human octave equivalence
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 26
year: '2023'
...
---
_id: '10727'
abstract:
- lang: eng
text: "Social insects are a common model to study disease dynamics in social animals.
Even though pathogens should thrive in social insect colonies as the hosts engage
in frequent social interactions, are closely related and live in a pathogen-rich
environment, disease outbreaks are rare. This is because social insects have evolved
mechanisms to keep pathogens at bay – and fight disease as a collective. Social
insect colonies are often viewed as “superorganisms” with division of labor between
reproductive “germ-like” queens and males and “somatic” workers, which together
form an interdependent reproductive unit that parallels a multicellular body.
Superorganisms possess a “social immune system” that comprises of collective disease
defenses performed by the workers - summarized as “social immunity”. In social
groups immunization (reduced susceptibility to a parasite upon secondary exposure
to the same parasite) can e.g. be triggered by social interactions (“social immunization”).
Social immunization can be caused by (i) asymptomatic low-level infections that
are acquired during caregiving to a contagious individual that can give an immune
boost, which can induce protection upon later encounter with the same pathogen
(active immunization) or (ii) by transfer of immune effectors between individuals
(passive immunization).\r\nIn the second chapter, I built up on a study that I
co-authored that found that low-level infections can not only be protective, but
also be costly and make the host more susceptible to detrimental superinfections
after contact to a very dissimilar pathogen. I here now tested different degrees
of phylogenetically-distant fungal strains of M. brunneum and M. robertsii in
L. neglectus and can describe the occurrence of cross-protection of social immunization
if the first and second pathogen are from the same level. Interestingly, low-level
infections only provided protection when the first strain was less virulent than
the second strain and elicited higher immune gene expression.\r\nIn the third
and fourth chapters, I expanded on the role of social immunity in sexual selection,
a so far unstudied field. I used the fungus Metarhizium robertsii and the ant
Cardiocondyla obscurior as a model, as in this species mating occurs in the presence
of workers and can be studied under laboratory conditions. Before males mate with
virgin queens in the nest they engage in fierce combat over the access to their
mating partners.\r\nFirst, I focused on male-male competition in the third chapter
and found that fighting with a contagious male is costly as it can lead to contamination
of the rival, but that workers can decrease the risk of disease contraction by
performing sanitary care.\r\nIn the fourth chapter, I studied the effect of fungal
infection on survival and mating success of sexuals (freshly emerged queens and
males) and found that worker-performed sanitary care can buffer the negative effect
that a pathogenic contagion would have on sexuals by spore removal from the exposed
individuals. When social immunity was prevented and queens could contract spores
from their mating partner, very low dosages led to negative consequences: their
lifespan was reduced and they produced fewer offspring with poor immunocompetence
compared to healthy queens. Interestingly, cohabitation with a late-stage infected
male where no spore transfer was possible had a positive effect on offspring immunity
– male offspring of mothers that apparently perceived an infected partner in their
vicinity reacted more sensitively to fungal challenge than male offspring without
paternal pathogen history."
acknowledged_ssus:
- _id: LifeSc
alternative_title:
- ISTA Thesis
article_processing_charge: No
author:
- first_name: Sina
full_name: Metzler, Sina
id: 48204546-F248-11E8-B48F-1D18A9856A87
last_name: Metzler
orcid: 0000-0002-9547-2494
citation:
ama: Metzler S. Pathogen-mediated sexual selection and immunization in ant colonies.
2022. doi:10.15479/AT:ISTA:10727
apa: Metzler, S. (2022). Pathogen-mediated sexual selection and immunization
in ant colonies. Institute of Science and Technology Austria. https://doi.org/10.15479/AT:ISTA:10727
chicago: Metzler, Sina. “Pathogen-Mediated Sexual Selection and Immunization in
Ant Colonies.” Institute of Science and Technology Austria, 2022. https://doi.org/10.15479/AT:ISTA:10727.
ieee: S. Metzler, “Pathogen-mediated sexual selection and immunization in ant colonies,”
Institute of Science and Technology Austria, 2022.
ista: Metzler S. 2022. Pathogen-mediated sexual selection and immunization in ant
colonies. Institute of Science and Technology Austria.
mla: Metzler, Sina. Pathogen-Mediated Sexual Selection and Immunization in Ant
Colonies. Institute of Science and Technology Austria, 2022, doi:10.15479/AT:ISTA:10727.
short: S. Metzler, Pathogen-Mediated Sexual Selection and Immunization in Ant Colonies,
Institute of Science and Technology Austria, 2022.
date_created: 2022-02-04T15:45:12Z
date_published: 2022-02-07T00:00:00Z
date_updated: 2023-09-07T13:43:23Z
day: '07'
ddc:
- '570'
degree_awarded: PhD
department:
- _id: GradSch
- _id: SyCr
doi: 10.15479/AT:ISTA:10727
ec_funded: 1
file:
- access_level: closed
checksum: 47ba18bb270dd6cc266e0a3f7c69d0e4
content_type: application/vnd.openxmlformats-officedocument.wordprocessingml.document
creator: smetzler
date_created: 2022-02-04T15:36:12Z
date_updated: 2023-02-03T23:30:03Z
embargo_to: open_access
file_id: '10728'
file_name: Thesis_Sina_Metzler.docx
file_size: 6757886
relation: source_file
- access_level: open_access
checksum: f3ec07d5d6b20ae6e46bfeedebce9027
content_type: application/pdf
creator: smetzler
date_created: 2022-02-04T15:36:43Z
date_updated: 2023-02-03T23:30:03Z
embargo: 2023-02-02
file_id: '10730'
file_name: Thesis_Sina_Metzler_A2.pdf
file_size: 6314921
relation: main_file
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checksum: dedd14b7be7a75d63018dbfc68dd8113
content_type: application/pdf
creator: smetzler
date_created: 2022-02-07T10:35:02Z
date_updated: 2023-02-04T23:30:03Z
embargo: 2023-02-02
file_id: '10742'
file_name: Thesis_Sina_Metzler_print.pdf
file_size: 6882557
relation: main_file
file_date_updated: 2023-02-04T23:30:03Z
has_accepted_license: '1'
language:
- iso: eng
month: '02'
oa: 1
oa_version: Published Version
project:
- _id: 2649B4DE-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '771402'
name: Epidemics in ant societies on a chip
publication_identifier:
issn:
- 2663-337X
publication_status: published
publisher: Institute of Science and Technology Austria
status: public
supervisor:
- first_name: Sylvia
full_name: Cremer, Sylvia
id: 2F64EC8C-F248-11E8-B48F-1D18A9856A87
last_name: Cremer
orcid: 0000-0002-2193-3868
title: Pathogen-mediated sexual selection and immunization in ant colonies
type: dissertation
user_id: c635000d-4b10-11ee-a964-aac5a93f6ac1
year: '2022'
...
---
_id: '10284'
abstract:
- lang: eng
text: Infections early in life can have enduring effects on an organism's development
and immunity. In this study, we show that this equally applies to developing ‘superorganisms’––incipient
social insect colonies. When we exposed newly mated Lasius niger ant queens to
a low pathogen dose, their colonies grew more slowly than controls before winter,
but reached similar sizes afterwards. Independent of exposure, queen hibernation
survival improved when the ratio of pupae to workers was small. Queens that reared
fewer pupae before worker emergence exhibited lower pathogen levels, indicating
that high brood rearing efforts interfere with the ability of the queen's immune
system to suppress pathogen proliferation. Early-life queen pathogen exposure
also improved the immunocompetence of her worker offspring, as demonstrated by
challenging the workers to the same pathogen a year later. Transgenerational transfer
of the queen's pathogen experience to her workforce can hence durably reduce the
disease susceptibility of the whole superorganism.
acknowledged_ssus:
- _id: ScienComp
acknowledgement: The authors are grateful to G. Tkačik and V. Mireles for advice on
data analyses and to A. Schloegl for help using the IST Austria HPC cluster for
data processing. The authors thank J. Eilenberg for providing the fungal strain
and A.V. Grasse for support with the molecular analysis. The authors also thank
the Social Immunity group at IST Austria, in particular B. Milutinović, for discussions
throughout and comments on the manuscript.
article_processing_charge: Yes (via OA deal)
article_type: original
author:
- first_name: Barbara E
full_name: Casillas Perez, Barbara E
id: 351ED2AA-F248-11E8-B48F-1D18A9856A87
last_name: Casillas Perez
- first_name: Christopher
full_name: Pull, Christopher
id: 3C7F4840-F248-11E8-B48F-1D18A9856A87
last_name: Pull
orcid: 0000-0003-1122-3982
- first_name: Filip
full_name: Naiser, Filip
last_name: Naiser
- first_name: Elisabeth
full_name: Naderlinger, Elisabeth
id: 31757262-F248-11E8-B48F-1D18A9856A87
last_name: Naderlinger
- first_name: Jiri
full_name: Matas, Jiri
last_name: Matas
- first_name: Sylvia
full_name: Cremer, Sylvia
id: 2F64EC8C-F248-11E8-B48F-1D18A9856A87
last_name: Cremer
orcid: 0000-0002-2193-3868
citation:
ama: Casillas Perez BE, Pull C, Naiser F, Naderlinger E, Matas J, Cremer S. Early
queen infection shapes developmental dynamics and induces long-term disease protection
in incipient ant colonies. Ecology Letters. 2022;25(1):89-100. doi:10.1111/ele.13907
apa: Casillas Perez, B. E., Pull, C., Naiser, F., Naderlinger, E., Matas, J., &
Cremer, S. (2022). Early queen infection shapes developmental dynamics and induces
long-term disease protection in incipient ant colonies. Ecology Letters.
Wiley. https://doi.org/10.1111/ele.13907
chicago: Casillas Perez, Barbara E, Christopher Pull, Filip Naiser, Elisabeth Naderlinger,
Jiri Matas, and Sylvia Cremer. “Early Queen Infection Shapes Developmental Dynamics
and Induces Long-Term Disease Protection in Incipient Ant Colonies.” Ecology
Letters. Wiley, 2022. https://doi.org/10.1111/ele.13907.
ieee: B. E. Casillas Perez, C. Pull, F. Naiser, E. Naderlinger, J. Matas, and S.
Cremer, “Early queen infection shapes developmental dynamics and induces long-term
disease protection in incipient ant colonies,” Ecology Letters, vol. 25,
no. 1. Wiley, pp. 89–100, 2022.
ista: Casillas Perez BE, Pull C, Naiser F, Naderlinger E, Matas J, Cremer S. 2022.
Early queen infection shapes developmental dynamics and induces long-term disease
protection in incipient ant colonies. Ecology Letters. 25(1), 89–100.
mla: Casillas Perez, Barbara E., et al. “Early Queen Infection Shapes Developmental
Dynamics and Induces Long-Term Disease Protection in Incipient Ant Colonies.”
Ecology Letters, vol. 25, no. 1, Wiley, 2022, pp. 89–100, doi:10.1111/ele.13907.
short: B.E. Casillas Perez, C. Pull, F. Naiser, E. Naderlinger, J. Matas, S. Cremer,
Ecology Letters 25 (2022) 89–100.
date_created: 2021-11-14T23:01:25Z
date_published: 2022-01-01T00:00:00Z
date_updated: 2023-08-14T11:45:29Z
day: '01'
ddc:
- '573'
department:
- _id: SyCr
doi: 10.1111/ele.13907
ec_funded: 1
external_id:
isi:
- '000713396100001'
pmid:
- '34725912'
file:
- access_level: open_access
checksum: 0bd4210400e9876609b7c538ab4f9a3c
content_type: application/pdf
creator: cchlebak
date_created: 2022-02-03T13:37:11Z
date_updated: 2022-02-03T13:37:11Z
file_id: '10721'
file_name: 2021_EcologyLetters_CasillasPerez.pdf
file_size: 700087
relation: main_file
success: 1
file_date_updated: 2022-02-03T13:37:11Z
has_accepted_license: '1'
intvolume: ' 25'
isi: 1
issue: '1'
language:
- iso: eng
month: '01'
oa: 1
oa_version: Published Version
page: 89-100
pmid: 1
project:
- _id: 2649B4DE-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '771402'
name: Epidemics in ant societies on a chip
publication: Ecology Letters
publication_identifier:
eissn:
- 1461-0248
issn:
- 1461-023X
publication_status: published
publisher: Wiley
quality_controlled: '1'
related_material:
record:
- id: '13061'
relation: research_data
status: public
scopus_import: '1'
status: public
title: Early queen infection shapes developmental dynamics and induces long-term disease
protection in incipient ant colonies
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 25
year: '2022'
...
---
_id: '12133'
abstract:
- lang: eng
text: Social distancing is an effective way to prevent the spread of disease in
societies, whereas infection elimination is a key element of organismal immunity.
Here, we discuss how the study of social insects such as ants — which form a superorganism
of unconditionally cooperative individuals and thus represent a level of organization
that is intermediate between a classical society of individuals and an organism
of cells — can help to determine common principles of disease defence across levels
of organization.
article_processing_charge: No
article_type: letter_note
author:
- first_name: Sylvia
full_name: Cremer, Sylvia
id: 2F64EC8C-F248-11E8-B48F-1D18A9856A87
last_name: Cremer
orcid: 0000-0002-2193-3868
- first_name: Michael K
full_name: Sixt, Michael K
id: 41E9FBEA-F248-11E8-B48F-1D18A9856A87
last_name: Sixt
orcid: 0000-0002-6620-9179
citation:
ama: Cremer S, Sixt MK. Principles of disease defence in organisms, superorganisms
and societies. Nature Reviews Immunology. 2022;22(12):713-714. doi:10.1038/s41577-022-00797-y
apa: Cremer, S., & Sixt, M. K. (2022). Principles of disease defence in organisms,
superorganisms and societies. Nature Reviews Immunology. Springer Nature.
https://doi.org/10.1038/s41577-022-00797-y
chicago: Cremer, Sylvia, and Michael K Sixt. “Principles of Disease Defence in Organisms,
Superorganisms and Societies.” Nature Reviews Immunology. Springer Nature,
2022. https://doi.org/10.1038/s41577-022-00797-y.
ieee: S. Cremer and M. K. Sixt, “Principles of disease defence in organisms, superorganisms
and societies,” Nature Reviews Immunology, vol. 22, no. 12. Springer Nature,
pp. 713–714, 2022.
ista: Cremer S, Sixt MK. 2022. Principles of disease defence in organisms, superorganisms
and societies. Nature Reviews Immunology. 22(12), 713–714.
mla: Cremer, Sylvia, and Michael K. Sixt. “Principles of Disease Defence in Organisms,
Superorganisms and Societies.” Nature Reviews Immunology, vol. 22, no.
12, Springer Nature, 2022, pp. 713–14, doi:10.1038/s41577-022-00797-y.
short: S. Cremer, M.K. Sixt, Nature Reviews Immunology 22 (2022) 713–714.
date_created: 2023-01-12T12:03:14Z
date_published: 2022-12-01T00:00:00Z
date_updated: 2023-08-04T08:53:32Z
day: '01'
department:
- _id: SyCr
- _id: MiSi
doi: 10.1038/s41577-022-00797-y
external_id:
isi:
- '000871836300001'
pmid:
- '36284178'
intvolume: ' 22'
isi: 1
issue: '12'
keyword:
- Energy Engineering and Power Technology
- Fuel Technology
language:
- iso: eng
month: '12'
oa_version: None
page: 713-714
pmid: 1
publication: Nature Reviews Immunology
publication_identifier:
eissn:
- 1474-1741
issn:
- 1474-1733
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
scopus_import: '1'
status: public
title: Principles of disease defence in organisms, superorganisms and societies
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 22
year: '2022'
...
---
_id: '13061'
abstract:
- lang: eng
text: Infections early in life can have enduring effects on an organism’s development
and immunity. In this study, we show that this equally applies to developing “superorganisms”
– incipient social insect colonies. When we exposed newly mated Lasius niger ant
queens to a low pathogen dose, their colonies grew more slowly than controls before
winter, but reached similar sizes afterwards. Independent of exposure, queen hibernation
survival improved when the ratio of pupae to workers was small. Queens that reared
fewer pupae before worker emergence exhibited lower pathogen levels, indicating
that high brood rearing efforts interfere with the ability of the queen’s immune
system to suppress pathogen proliferation. Early-life queen pathogen-exposure
also improved the immunocompetence of her worker offspring, as demonstrated by
challenging the workers to the same pathogen a year later. Transgenerational transfer
of the queen’s pathogen experience to her workforce can hence durably reduce the
disease susceptibility of the whole superorganism.
article_processing_charge: No
author:
- first_name: Barbara E
full_name: Casillas Perez, Barbara E
id: 351ED2AA-F248-11E8-B48F-1D18A9856A87
last_name: Casillas Perez
- first_name: Christopher
full_name: Pull, Christopher
id: 3C7F4840-F248-11E8-B48F-1D18A9856A87
last_name: Pull
orcid: 0000-0003-1122-3982
- first_name: Filip
full_name: Naiser, Filip
last_name: Naiser
- first_name: Elisabeth
full_name: Naderlinger, Elisabeth
last_name: Naderlinger
- first_name: Jiri
full_name: Matas, Jiri
last_name: Matas
- first_name: Sylvia
full_name: Cremer, Sylvia
id: 2F64EC8C-F248-11E8-B48F-1D18A9856A87
last_name: Cremer
orcid: 0000-0002-2193-3868
citation:
ama: Casillas Perez BE, Pull C, Naiser F, Naderlinger E, Matas J, Cremer S. Early
queen infection shapes developmental dynamics and induces long-term disease protection
in incipient ant colonies. 2021. doi:10.5061/DRYAD.7PVMCVDTJ
apa: Casillas Perez, B. E., Pull, C., Naiser, F., Naderlinger, E., Matas, J., &
Cremer, S. (2021). Early queen infection shapes developmental dynamics and induces
long-term disease protection in incipient ant colonies. Dryad. https://doi.org/10.5061/DRYAD.7PVMCVDTJ
chicago: Casillas Perez, Barbara E, Christopher Pull, Filip Naiser, Elisabeth Naderlinger,
Jiri Matas, and Sylvia Cremer. “Early Queen Infection Shapes Developmental Dynamics
and Induces Long-Term Disease Protection in Incipient Ant Colonies.” Dryad, 2021.
https://doi.org/10.5061/DRYAD.7PVMCVDTJ.
ieee: B. E. Casillas Perez, C. Pull, F. Naiser, E. Naderlinger, J. Matas, and S.
Cremer, “Early queen infection shapes developmental dynamics and induces long-term
disease protection in incipient ant colonies.” Dryad, 2021.
ista: Casillas Perez BE, Pull C, Naiser F, Naderlinger E, Matas J, Cremer S. 2021.
Early queen infection shapes developmental dynamics and induces long-term disease
protection in incipient ant colonies, Dryad, 10.5061/DRYAD.7PVMCVDTJ.
mla: Casillas Perez, Barbara E., et al. Early Queen Infection Shapes Developmental
Dynamics and Induces Long-Term Disease Protection in Incipient Ant Colonies.
Dryad, 2021, doi:10.5061/DRYAD.7PVMCVDTJ.
short: B.E. Casillas Perez, C. Pull, F. Naiser, E. Naderlinger, J. Matas, S. Cremer,
(2021).
date_created: 2023-05-23T16:14:35Z
date_published: 2021-10-29T00:00:00Z
date_updated: 2023-08-14T11:45:28Z
day: '29'
ddc:
- '570'
department:
- _id: SyCr
doi: 10.5061/DRYAD.7PVMCVDTJ
ec_funded: 1
license: https://creativecommons.org/publicdomain/zero/1.0/
main_file_link:
- open_access: '1'
url: https://doi.org/10.5061/dryad.7pvmcvdtj
month: '10'
oa: 1
oa_version: Published Version
project:
- _id: 2649B4DE-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '771402'
name: Epidemics in ant societies on a chip
publisher: Dryad
related_material:
record:
- id: '10284'
relation: used_in_publication
status: public
status: public
title: Early queen infection shapes developmental dynamics and induces long-term disease
protection in incipient ant colonies
tmp:
image: /images/cc_0.png
legal_code_url: https://creativecommons.org/publicdomain/zero/1.0/legalcode
name: Creative Commons Public Domain Dedication (CC0 1.0)
short: CC0 (1.0)
type: research_data_reference
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '2021'
...
---
_id: '9101'
abstract:
- lang: eng
text: 'Behavioral predispositions are innate tendencies of animals to behave in
a given way without the input of learning. They increase survival chances and,
due to environmental and ecological challenges, may vary substantially even between
closely related taxa. These differences are likely to be especially pronounced
in long-lived species like crocodilians. This order is particularly relevant for
comparative cognition due to its phylogenetic proximity to birds. Here we compared
early life behavioral predispositions in two Alligatoridae species. We exposed
American alligator and spectacled caiman hatchlings to three different novel situations:
a novel object, a novel environment that was open and a novel environment with
a shelter. This was then repeated a week later. During exposure to the novel environments,
alligators moved around more and explored a larger range of the arena than the
caimans. When exposed to the novel object, the alligators reduced the mean distance
to the novel object in the second phase, while the caimans further increased it,
indicating diametrically opposite ontogenetic development in behavioral predispositions.
Although all crocodilian hatchlings face comparable challenges, e.g., high predation
pressure, the effectiveness of parental protection might explain the observed
pattern. American alligators are apex predators capable of protecting their offspring
against most dangers, whereas adult spectacled caimans are frequently predated
themselves. Their distancing behavior might be related to increased predator avoidance
and also explain the success of invasive spectacled caimans in the natural habitats
of other crocodilians.'
acknowledgement: We thank Jamie Gilks and Terry Miles for their support at Crocodiles
of the World. We are grateful to the Department of Cognitive Biology, University
of Vienna for provision of working space and hardware. Finally, we would like to
thank Cliodhna Quigley, Rachael Harrison and Urs A. Reber for discussion. Open Access
funding provided by Lund University. This project was funded by the Marietta Blau
grant (BMFWF) to S. A. R.
article_processing_charge: No
article_type: original
author:
- first_name: Stephan A.
full_name: Reber, Stephan A.
last_name: Reber
- first_name: Jinook
full_name: Oh, Jinook
id: 403169A4-080F-11EA-9993-BF3F3DDC885E
last_name: Oh
orcid: 0000-0001-7425-2372
- first_name: Judith
full_name: Janisch, Judith
last_name: Janisch
- first_name: Colin
full_name: Stevenson, Colin
last_name: Stevenson
- first_name: Shaun
full_name: Foggett, Shaun
last_name: Foggett
- first_name: Anna
full_name: Wilkinson, Anna
last_name: Wilkinson
citation:
ama: Reber SA, Oh J, Janisch J, Stevenson C, Foggett S, Wilkinson A. Early life
differences in behavioral predispositions in two Alligatoridae species. Animal
Cognition. 2021;24(4):753-764. doi:10.1007/s10071-020-01461-5
apa: Reber, S. A., Oh, J., Janisch, J., Stevenson, C., Foggett, S., & Wilkinson,
A. (2021). Early life differences in behavioral predispositions in two Alligatoridae
species. Animal Cognition. Springer Nature. https://doi.org/10.1007/s10071-020-01461-5
chicago: Reber, Stephan A., Jinook Oh, Judith Janisch, Colin Stevenson, Shaun Foggett,
and Anna Wilkinson. “Early Life Differences in Behavioral Predispositions in Two
Alligatoridae Species.” Animal Cognition. Springer Nature, 2021. https://doi.org/10.1007/s10071-020-01461-5.
ieee: S. A. Reber, J. Oh, J. Janisch, C. Stevenson, S. Foggett, and A. Wilkinson,
“Early life differences in behavioral predispositions in two Alligatoridae species,”
Animal Cognition, vol. 24, no. 4. Springer Nature, pp. 753–764, 2021.
ista: Reber SA, Oh J, Janisch J, Stevenson C, Foggett S, Wilkinson A. 2021. Early
life differences in behavioral predispositions in two Alligatoridae species. Animal
Cognition. 24(4), 753–764.
mla: Reber, Stephan A., et al. “Early Life Differences in Behavioral Predispositions
in Two Alligatoridae Species.” Animal Cognition, vol. 24, no. 4, Springer
Nature, 2021, pp. 753–64, doi:10.1007/s10071-020-01461-5.
short: S.A. Reber, J. Oh, J. Janisch, C. Stevenson, S. Foggett, A. Wilkinson, Animal
Cognition 24 (2021) 753–764.
date_created: 2021-02-07T23:01:13Z
date_published: 2021-07-01T00:00:00Z
date_updated: 2023-08-07T13:41:08Z
day: '01'
ddc:
- '590'
department:
- _id: SyCr
doi: 10.1007/s10071-020-01461-5
external_id:
isi:
- '000608382100001'
file:
- access_level: open_access
checksum: d9dfa0d1de6d684692b041d936dd858e
content_type: application/pdf
creator: dernst
date_created: 2021-02-09T07:40:14Z
date_updated: 2021-02-09T07:40:14Z
file_id: '9107'
file_name: 2021_AnimalCognition_Reber.pdf
file_size: 1117991
relation: main_file
success: 1
file_date_updated: 2021-02-09T07:40:14Z
has_accepted_license: '1'
intvolume: ' 24'
isi: 1
issue: '4'
language:
- iso: eng
month: '07'
oa: 1
oa_version: Published Version
page: 753-764
publication: Animal Cognition
publication_identifier:
eissn:
- '14359456'
issn:
- '14359448'
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
scopus_import: '1'
status: public
title: Early life differences in behavioral predispositions in two Alligatoridae species
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 24
year: '2021'
...
---
_id: '10568'
abstract:
- lang: eng
text: Genetic adaptation and phenotypic plasticity facilitate the migration into
new habitats and enable organisms to cope with a rapidly changing environment.
In contrast to genetic adaptation that spans multiple generations as an evolutionary
process, phenotypic plasticity allows acclimation within the life-time of an organism.
Genetic adaptation and phenotypic plasticity are usually studied in isolation,
however, only by including their interactive impact, we can understand acclimation
and adaptation in nature. We aimed to explore the contribution of adaptation and
plasticity in coping with an abiotic (salinity) and a biotic (Vibrio bacteria)
stressor using six different populations of the broad-nosed pipefish Syngnathus
typhle that originated from either high [14–17 Practical Salinity Unit (PSU)]
or low (7–11 PSU) saline environments along the German coastline of the Baltic
Sea. We exposed wild caught animals, to either high (15 PSU) or low (7 PSU) salinity,
representing native and novel salinity conditions and allowed animals to mate.
After male pregnancy, offspring was split and each half was exposed to one of
the two salinities and infected with Vibrio alginolyticus bacteria that were evolved
at either of the two salinities in a fully reciprocal design. We investigated
life-history traits of fathers and expression of 47 target genes in mothers and
offspring. Pregnant males originating from high salinity exposed to low salinity
were highly susceptible to opportunistic fungi infections resulting in decreased
offspring size and number. In contrast, no signs of fungal infection were identified
in fathers originating from low saline conditions suggesting that genetic adaptation
has the potential to overcome the challenges encountered at low salinity. Offspring
from parents with low saline origin survived better at low salinity suggesting
genetic adaptation to low salinity. In addition, gene expression analyses of juveniles
indicated patterns of local adaptation, trans-generational plasticity and developmental
plasticity. In conclusion, our study suggests that pipefish are locally adapted
to the low salinity in their environment, however, they are retaining phenotypic
plasticity, which allows them to also cope with ancestral salinity levels and
prevailing pathogens.
acknowledgement: We are grateful for the help of Kristina Dauven, Andreas Ebner, Janina
Röckner, and Paulina Urban for fish collection in the field and fish maintenance.
Furthermore, we thank Fabian Wendt for setting up the aquaria system and Tatjana
Liese, Paulina Urban, Jakob Gismann, and Thorsten Reusch for support with DNA extraction
and analysis of pipefish population structure. The authors acknowledge support of
Isabel Tanger, Agnes Piecyk, Jonas Müller, Grace Walls, Sebastian Albrecht, Julia
Böge, and Julia Stefanschitz for their support in preparing cDNA and running of
Fluidigm chips. A special thank goes to Diana Gill for general lab support, ordering
materials and just being the good spirit of our molecular lab, to Till Bayer for
bioinformatics support and to Melanie Heckwolf for fruitful discussion and feedback
on the manuscript. HG is very grateful for inspirational office space with ocean
view provided by Lisa Hentschel and family. This manuscript has been released as
a pre-print at BIORXIV.
article_number: '626442'
article_processing_charge: No
article_type: original
author:
- first_name: Henry
full_name: Goehlich, Henry
last_name: Goehlich
- first_name: Linda
full_name: Sartoris, Linda
id: 2B9284CA-F248-11E8-B48F-1D18A9856A87
last_name: Sartoris
- first_name: Kim-Sara
full_name: Wagner, Kim-Sara
last_name: Wagner
- first_name: Carolin C.
full_name: Wendling, Carolin C.
last_name: Wendling
- first_name: Olivia
full_name: Roth, Olivia
last_name: Roth
citation:
ama: Goehlich H, Sartoris L, Wagner K-S, Wendling CC, Roth O. Pipefish locally adapted
to low salinity in the Baltic Sea retain phenotypic plasticity to cope with ancestral
salinity levels. Frontiers in Ecology and Evolution. 2021;9. doi:10.3389/fevo.2021.626442
apa: Goehlich, H., Sartoris, L., Wagner, K.-S., Wendling, C. C., & Roth, O.
(2021). Pipefish locally adapted to low salinity in the Baltic Sea retain phenotypic
plasticity to cope with ancestral salinity levels. Frontiers in Ecology and
Evolution. Frontiers Media. https://doi.org/10.3389/fevo.2021.626442
chicago: Goehlich, Henry, Linda Sartoris, Kim-Sara Wagner, Carolin C. Wendling,
and Olivia Roth. “Pipefish Locally Adapted to Low Salinity in the Baltic Sea Retain
Phenotypic Plasticity to Cope with Ancestral Salinity Levels.” Frontiers in
Ecology and Evolution. Frontiers Media, 2021. https://doi.org/10.3389/fevo.2021.626442.
ieee: H. Goehlich, L. Sartoris, K.-S. Wagner, C. C. Wendling, and O. Roth, “Pipefish
locally adapted to low salinity in the Baltic Sea retain phenotypic plasticity
to cope with ancestral salinity levels,” Frontiers in Ecology and Evolution,
vol. 9. Frontiers Media, 2021.
ista: Goehlich H, Sartoris L, Wagner K-S, Wendling CC, Roth O. 2021. Pipefish locally
adapted to low salinity in the Baltic Sea retain phenotypic plasticity to cope
with ancestral salinity levels. Frontiers in Ecology and Evolution. 9, 626442.
mla: Goehlich, Henry, et al. “Pipefish Locally Adapted to Low Salinity in the Baltic
Sea Retain Phenotypic Plasticity to Cope with Ancestral Salinity Levels.” Frontiers
in Ecology and Evolution, vol. 9, 626442, Frontiers Media, 2021, doi:10.3389/fevo.2021.626442.
short: H. Goehlich, L. Sartoris, K.-S. Wagner, C.C. Wendling, O. Roth, Frontiers
in Ecology and Evolution 9 (2021).
date_created: 2021-12-20T07:53:19Z
date_published: 2021-03-25T00:00:00Z
date_updated: 2023-08-17T06:27:22Z
day: '25'
ddc:
- '597'
department:
- _id: SyCr
doi: 10.3389/fevo.2021.626442
external_id:
isi:
- '000637736300001'
file:
- access_level: open_access
checksum: 8d6e2b767bb0240a9b5a3a3555be51fd
content_type: application/pdf
creator: alisjak
date_created: 2021-12-20T10:44:20Z
date_updated: 2021-12-20T10:44:20Z
file_id: '10572'
file_name: 2021_Frontiers_Goehlich.pdf
file_size: 3175085
relation: main_file
success: 1
file_date_updated: 2021-12-20T10:44:20Z
has_accepted_license: '1'
intvolume: ' 9'
isi: 1
keyword:
- ecology
- evolution
- behavior and systematics
- trans-generational plasticity
- genetic adaptation
- local adaptation
- phenotypic plasticity
- Baltic Sea
- climate change
- salinity
- syngnathids
language:
- iso: eng
month: '03'
oa: 1
oa_version: Published Version
publication: Frontiers in Ecology and Evolution
publication_identifier:
issn:
- 2296-701X
publication_status: published
publisher: Frontiers Media
quality_controlled: '1'
scopus_import: '1'
status: public
title: Pipefish locally adapted to low salinity in the Baltic Sea retain phenotypic
plasticity to cope with ancestral salinity levels
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 9
year: '2021'
...
---
_id: '10569'
abstract:
- lang: eng
text: 'For animals to survive until reproduction, it is crucial that juveniles successfully
detect potential predators and respond with appropriate behavior. The recognition
of cues originating from predators can be innate or learned. Cues of various modalities
might be used alone or in multi-modal combinations to detect and distinguish predators
but studies investigating multi-modal integration in predator avoidance are scarce.
Here, we used wild, naive tadpoles of the Neotropical poison frog Allobates femoralis
( Boulenger, 1884) to test their reaction to cues with two modalities from two
different sympatrically occurring potential predators: heterospecific predatory
Dendrobates tinctorius tadpoles and dragonfly larvae. We presented A. femoralis
tadpoles with olfactory or visual cues, or a combination of the two, and compared
their reaction to a water control in a between-individual design. In our trials,
A. femoralis tadpoles reacted to multi-modal stimuli (a combination of visual
and chemical information) originating from dragonfly larvae with avoidance but
showed no reaction to uni-modal cues or cues from heterospecific tadpoles. In
addition, visual cues from conspecifics increased swimming activity while cues
from predators had no effect on tadpole activity. Our results show that A. femoralis
tadpoles can innately recognize some predators and probably need both visual and
chemical information to effectively avoid them. This is the first study looking
at anti-predator behavior in poison frog tadpoles. We discuss how parental care
might influence the expression of predator avoidance responses in tadpoles.'
acknowledgement: We are grateful to Véronique Helfer, Walter Hödl, Lisa Schretzmeyer
and Julia Wotke, who assisted with fieldwork in French Guiana. This work was supported
by the Austrian Science Fund (FWF) [P24788, T699 and P31518 to E.R.; P33728 to M.R.;
J3827 to Thomas Bugnyar, Tecumseh Fitch and Ludwig Huber]; and by the Austrian Bundesministerium
für Wissenschaft, Forschung und Wirtschaft [IS761001 to J.O. (Tecumseh Fitch, Thomas
Bugnyar and Ludwig Huber)]. A.P. was supported by the European Union's Horizon 2020
research and innovation programme under the Marie Sklodowska-Curie grant agreement
no. 835530. S.A.R. was supported by the HT faculty, Lund University. We thank the
CNRS Nouragues Ecological Research Station, which benefited from the ‘Investissement
d'Avenir’ grants managed by the Agence Nationale de la Recherche (AnaEE France ANR-11-INBS-0001;
Labex CEBA ANR-10-LABX-25-01). Open access funding provided by University of Vienna.
Deposited in PMC for immediate release.
article_number: jeb243647
article_processing_charge: No
article_type: original
author:
- first_name: B
full_name: Szabo, B
last_name: Szabo
- first_name: R
full_name: Mangione, R
last_name: Mangione
- first_name: M
full_name: Rath, M
last_name: Rath
- first_name: A
full_name: Pašukonis, A
last_name: Pašukonis
- first_name: SA
full_name: Reber, SA
last_name: Reber
- first_name: Jinook
full_name: Oh, Jinook
id: 403169A4-080F-11EA-9993-BF3F3DDC885E
last_name: Oh
orcid: 0000-0001-7425-2372
- first_name: M
full_name: Ringler, M
last_name: Ringler
- first_name: E
full_name: Ringler, E
last_name: Ringler
citation:
ama: Szabo B, Mangione R, Rath M, et al. Naïve poison frog tadpoles use bi-modal
cues to avoid insect predators but not heterospecific predatory tadpoles. Journal
of Experimental Biology. 2021;224(24). doi:10.1242/jeb.243647
apa: Szabo, B., Mangione, R., Rath, M., Pašukonis, A., Reber, S., Oh, J., … Ringler,
E. (2021). Naïve poison frog tadpoles use bi-modal cues to avoid insect predators
but not heterospecific predatory tadpoles. Journal of Experimental Biology.
The Company of Biologists. https://doi.org/10.1242/jeb.243647
chicago: Szabo, B, R Mangione, M Rath, A Pašukonis, SA Reber, Jinook Oh, M Ringler,
and E Ringler. “Naïve Poison Frog Tadpoles Use Bi-Modal Cues to Avoid Insect Predators
but Not Heterospecific Predatory Tadpoles.” Journal of Experimental Biology.
The Company of Biologists, 2021. https://doi.org/10.1242/jeb.243647.
ieee: B. Szabo et al., “Naïve poison frog tadpoles use bi-modal cues to avoid
insect predators but not heterospecific predatory tadpoles,” Journal of Experimental
Biology, vol. 224, no. 24. The Company of Biologists, 2021.
ista: Szabo B, Mangione R, Rath M, Pašukonis A, Reber S, Oh J, Ringler M, Ringler
E. 2021. Naïve poison frog tadpoles use bi-modal cues to avoid insect predators
but not heterospecific predatory tadpoles. Journal of Experimental Biology. 224(24),
jeb243647.
mla: Szabo, B., et al. “Naïve Poison Frog Tadpoles Use Bi-Modal Cues to Avoid Insect
Predators but Not Heterospecific Predatory Tadpoles.” Journal of Experimental
Biology, vol. 224, no. 24, jeb243647, The Company of Biologists, 2021, doi:10.1242/jeb.243647.
short: B. Szabo, R. Mangione, M. Rath, A. Pašukonis, S. Reber, J. Oh, M. Ringler,
E. Ringler, Journal of Experimental Biology 224 (2021).
date_created: 2021-12-20T07:54:22Z
date_published: 2021-12-16T00:00:00Z
date_updated: 2023-08-17T06:26:15Z
day: '16'
ddc:
- '573'
department:
- _id: SyCr
doi: 10.1242/jeb.243647
external_id:
isi:
- '000738259300013'
pmid:
- '34845497'
file:
- access_level: open_access
checksum: 75d13a5ec8e3b90e3bc02bd8a9c17eef
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creator: cchlebak
date_created: 2021-12-20T10:14:14Z
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file_name: 2021_JExpBio_Szabo.pdf
file_size: 607096
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issue: '24'
language:
- iso: eng
month: '12'
oa: 1
oa_version: Published Version
pmid: 1
publication: Journal of Experimental Biology
publication_identifier:
eissn:
- 1477-9145
issn:
- 0022-0949
publication_status: published
publisher: The Company of Biologists
quality_controlled: '1'
status: public
title: Naïve poison frog tadpoles use bi-modal cues to avoid insect predators but
not heterospecific predatory tadpoles
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 224
year: '2021'
...
---
_id: '7343'
abstract:
- lang: eng
text: Coinfections with multiple pathogens can result in complex within‐host dynamics
affecting virulence and transmission. While multiple infections are intensively
studied in solitary hosts, it is so far unresolved how social host interactions
interfere with pathogen competition, and if this depends on coinfection diversity.
We studied how the collective disease defences of ants – their social immunity
– influence pathogen competition in coinfections of same or different fungal pathogen
species. Social immunity reduced virulence for all pathogen combinations, but
interfered with spore production only in different‐species coinfections. Here,
it decreased overall pathogen sporulation success while increasing co‐sporulation
on individual cadavers and maintaining a higher pathogen diversity at the community
level. Mathematical modelling revealed that host sanitary care alone can modulate
competitive outcomes between pathogens, giving advantage to fast‐germinating,
thus less grooming‐sensitive ones. Host social interactions can hence modulate
infection dynamics in coinfected group members, thereby altering pathogen communities
at the host level and population level.
acknowledged_ssus:
- _id: LifeSc
acknowledgement: "We thank Bernhardt Steinwender and Jorgen Eilenberg for the fungal
strains, Xavier Espadaler, Mireia Diaz, Christiane Wanke, Lumi Viljakainen and the
Social Immunity Team at IST Austria, for help with ant collection, and Wanda Gorecka
and Gertraud Stift of the IST Austria Life Science Facility for technical support.
We are thankful to Dieter Ebert for input at all stages of the project, Roger Mundry
for statistical advice, Hinrich Schulenburg, Paul Schmid-Hempel, Yuko\r\nUlrich
and Joachim Kurtz for project discussion, Bor Kavcic for advice on growth curves,
Marcus Roper for advice on modelling work and comments on the manuscript, as well
as Marjon de Vos, Weini Huang and the Social Immunity Team for comments on the manuscript.\r\nThis
study was funded by the German Research Foundation (DFG) within the Priority Programme
1399 Host-parasite Coevolution (CR 118/3 to S.C.) and the People Programme\r\n(Marie
Curie Actions) of the European Union’s Seventh Framework Programme (FP7/2007-2013)
under REA grant agreement no 291734 (ISTFELLOW to B.M.). "
article_processing_charge: Yes (via OA deal)
article_type: letter_note
author:
- first_name: Barbara
full_name: Milutinovic, Barbara
id: 2CDC32B8-F248-11E8-B48F-1D18A9856A87
last_name: Milutinovic
orcid: 0000-0002-8214-4758
- first_name: Miriam
full_name: Stock, Miriam
id: 42462816-F248-11E8-B48F-1D18A9856A87
last_name: Stock
- first_name: Anna V
full_name: Grasse, Anna V
id: 406F989C-F248-11E8-B48F-1D18A9856A87
last_name: Grasse
- first_name: Elisabeth
full_name: Naderlinger, Elisabeth
id: 31757262-F248-11E8-B48F-1D18A9856A87
last_name: Naderlinger
- first_name: Christian
full_name: Hilbe, Christian
id: 2FDF8F3C-F248-11E8-B48F-1D18A9856A87
last_name: Hilbe
orcid: 0000-0001-5116-955X
- first_name: Sylvia
full_name: Cremer, Sylvia
id: 2F64EC8C-F248-11E8-B48F-1D18A9856A87
last_name: Cremer
orcid: 0000-0002-2193-3868
citation:
ama: Milutinovic B, Stock M, Grasse AV, Naderlinger E, Hilbe C, Cremer S. Social
immunity modulates competition between coinfecting pathogens. Ecology Letters.
2020;23(3):565-574. doi:10.1111/ele.13458
apa: Milutinovic, B., Stock, M., Grasse, A. V., Naderlinger, E., Hilbe, C., &
Cremer, S. (2020). Social immunity modulates competition between coinfecting pathogens.
Ecology Letters. Wiley. https://doi.org/10.1111/ele.13458
chicago: Milutinovic, Barbara, Miriam Stock, Anna V Grasse, Elisabeth Naderlinger,
Christian Hilbe, and Sylvia Cremer. “Social Immunity Modulates Competition between
Coinfecting Pathogens.” Ecology Letters. Wiley, 2020. https://doi.org/10.1111/ele.13458.
ieee: B. Milutinovic, M. Stock, A. V. Grasse, E. Naderlinger, C. Hilbe, and S. Cremer,
“Social immunity modulates competition between coinfecting pathogens,” Ecology
Letters, vol. 23, no. 3. Wiley, pp. 565–574, 2020.
ista: Milutinovic B, Stock M, Grasse AV, Naderlinger E, Hilbe C, Cremer S. 2020.
Social immunity modulates competition between coinfecting pathogens. Ecology Letters.
23(3), 565–574.
mla: Milutinovic, Barbara, et al. “Social Immunity Modulates Competition between
Coinfecting Pathogens.” Ecology Letters, vol. 23, no. 3, Wiley, 2020, pp.
565–74, doi:10.1111/ele.13458.
short: B. Milutinovic, M. Stock, A.V. Grasse, E. Naderlinger, C. Hilbe, S. Cremer,
Ecology Letters 23 (2020) 565–574.
date_created: 2020-01-20T13:32:12Z
date_published: 2020-03-01T00:00:00Z
date_updated: 2023-09-05T16:04:49Z
day: '01'
ddc:
- '570'
department:
- _id: SyCr
- _id: KrCh
doi: 10.1111/ele.13458
ec_funded: 1
external_id:
isi:
- '000507515900001'
file:
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checksum: 0cd8be386fa219db02845b7c3991ce04
content_type: application/pdf
creator: dernst
date_created: 2020-11-19T11:27:10Z
date_updated: 2020-11-19T11:27:10Z
file_id: '8776'
file_name: 2020_EcologyLetters_Milutinovic.pdf
file_size: 561749
relation: main_file
success: 1
file_date_updated: 2020-11-19T11:27:10Z
has_accepted_license: '1'
intvolume: ' 23'
isi: 1
issue: '3'
language:
- iso: eng
month: '03'
oa: 1
oa_version: Published Version
page: 565-574
project:
- _id: 25681D80-B435-11E9-9278-68D0E5697425
call_identifier: FP7
grant_number: '291734'
name: International IST Postdoc Fellowship Programme
- _id: 25DAF0B2-B435-11E9-9278-68D0E5697425
grant_number: CR-118/3-1
name: Host-Parasite Coevolution
publication: Ecology Letters
publication_identifier:
eissn:
- 1461-0248
issn:
- 1461-023X
publication_status: published
publisher: Wiley
quality_controlled: '1'
related_material:
link:
- description: News on IST Homepage
relation: press_release
url: https://ist.ac.at/en/news/social-ants-shapes-disease-outcome/
record:
- id: '13060'
relation: research_data
status: public
scopus_import: '1'
status: public
title: Social immunity modulates competition between coinfecting pathogens
tmp:
image: /images/cc_by_nc.png
legal_code_url: https://creativecommons.org/licenses/by-nc/4.0/legalcode
name: Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0)
short: CC BY-NC (4.0)
type: journal_article
user_id: c635000d-4b10-11ee-a964-aac5a93f6ac1
volume: 23
year: '2020'
...
---
_id: '7490'
abstract:
- lang: eng
text: In plants, clathrin mediated endocytosis (CME) represents the major route
for cargo internalisation from the cell surface. It has been assumed to operate
in an evolutionary conserved manner as in yeast and animals. Here we report characterisation
of ultrastructure, dynamics and mechanisms of plant CME as allowed by our advancement
in electron microscopy and quantitative live imaging techniques. Arabidopsis CME
appears to follow the constant curvature model and the bona fide CME population
generates vesicles of a predominantly hexagonal-basket type; larger and with faster
kinetics than in other models. Contrary to the existing paradigm, actin is dispensable
for CME events at the plasma membrane but plays a unique role in collecting endocytic
vesicles, sorting of internalised cargos and directional endosome movement that
itself actively promote CME events. Internalized vesicles display a strongly delayed
and sequential uncoating. These unique features highlight the independent evolution
of the plant CME mechanism during the autonomous rise of multicellularity in eukaryotes.
acknowledged_ssus:
- _id: LifeSc
- _id: Bio
- _id: EM-Fac
article_number: e52067
article_processing_charge: No
article_type: original
author:
- first_name: Madhumitha
full_name: Narasimhan, Madhumitha
id: 44BF24D0-F248-11E8-B48F-1D18A9856A87
last_name: Narasimhan
orcid: 0000-0002-8600-0671
- first_name: Alexander J
full_name: Johnson, Alexander J
id: 46A62C3A-F248-11E8-B48F-1D18A9856A87
last_name: Johnson
orcid: 0000-0002-2739-8843
- first_name: Roshan
full_name: Prizak, Roshan
id: 4456104E-F248-11E8-B48F-1D18A9856A87
last_name: Prizak
- first_name: Walter
full_name: Kaufmann, Walter
id: 3F99E422-F248-11E8-B48F-1D18A9856A87
last_name: Kaufmann
orcid: 0000-0001-9735-5315
- first_name: Shutang
full_name: Tan, Shutang
id: 2DE75584-F248-11E8-B48F-1D18A9856A87
last_name: Tan
orcid: 0000-0002-0471-8285
- first_name: Barbara E
full_name: Casillas Perez, Barbara E
id: 351ED2AA-F248-11E8-B48F-1D18A9856A87
last_name: Casillas Perez
- first_name: Jiří
full_name: Friml, Jiří
id: 4159519E-F248-11E8-B48F-1D18A9856A87
last_name: Friml
orcid: 0000-0002-8302-7596
citation:
ama: Narasimhan M, Johnson AJ, Prizak R, et al. Evolutionarily unique mechanistic
framework of clathrin-mediated endocytosis in plants. eLife. 2020;9. doi:10.7554/eLife.52067
apa: Narasimhan, M., Johnson, A. J., Prizak, R., Kaufmann, W., Tan, S., Casillas
Perez, B. E., & Friml, J. (2020). Evolutionarily unique mechanistic framework
of clathrin-mediated endocytosis in plants. ELife. eLife Sciences Publications.
https://doi.org/10.7554/eLife.52067
chicago: Narasimhan, Madhumitha, Alexander J Johnson, Roshan Prizak, Walter Kaufmann,
Shutang Tan, Barbara E Casillas Perez, and Jiří Friml. “Evolutionarily Unique
Mechanistic Framework of Clathrin-Mediated Endocytosis in Plants.” ELife.
eLife Sciences Publications, 2020. https://doi.org/10.7554/eLife.52067.
ieee: M. Narasimhan et al., “Evolutionarily unique mechanistic framework
of clathrin-mediated endocytosis in plants,” eLife, vol. 9. eLife Sciences
Publications, 2020.
ista: Narasimhan M, Johnson AJ, Prizak R, Kaufmann W, Tan S, Casillas Perez BE,
Friml J. 2020. Evolutionarily unique mechanistic framework of clathrin-mediated
endocytosis in plants. eLife. 9, e52067.
mla: Narasimhan, Madhumitha, et al. “Evolutionarily Unique Mechanistic Framework
of Clathrin-Mediated Endocytosis in Plants.” ELife, vol. 9, e52067, eLife
Sciences Publications, 2020, doi:10.7554/eLife.52067.
short: M. Narasimhan, A.J. Johnson, R. Prizak, W. Kaufmann, S. Tan, B.E. Casillas
Perez, J. Friml, ELife 9 (2020).
date_created: 2020-02-16T23:00:50Z
date_published: 2020-01-23T00:00:00Z
date_updated: 2023-08-18T06:33:07Z
day: '23'
ddc:
- '570'
- '580'
department:
- _id: JiFr
- _id: GaTk
- _id: EM-Fac
- _id: SyCr
doi: 10.7554/eLife.52067
ec_funded: 1
external_id:
isi:
- '000514104100001'
pmid:
- '31971511'
file:
- access_level: open_access
checksum: 2052daa4be5019534f3a42f200a09f32
content_type: application/pdf
creator: dernst
date_created: 2020-02-18T07:21:16Z
date_updated: 2020-07-14T12:47:59Z
file_id: '7494'
file_name: 2020_eLife_Narasimhan.pdf
file_size: 7247468
relation: main_file
file_date_updated: 2020-07-14T12:47:59Z
has_accepted_license: '1'
intvolume: ' 9'
isi: 1
language:
- iso: eng
month: '01'
oa: 1
oa_version: Published Version
pmid: 1
project:
- _id: 261099A6-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '742985'
name: Tracing Evolution of Auxin Transport and Polarity in Plants
- _id: 26538374-B435-11E9-9278-68D0E5697425
call_identifier: FWF
grant_number: I03630
name: Molecular mechanisms of endocytic cargo recognition in plants
publication: eLife
publication_identifier:
eissn:
- 2050-084X
publication_status: published
publisher: eLife Sciences Publications
quality_controlled: '1'
scopus_import: '1'
status: public
title: Evolutionarily unique mechanistic framework of clathrin-mediated endocytosis
in plants
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 9
year: '2020'
...