---
_id: '10642'
abstract:
- lang: eng
text: Based on a result by Yarotsky (J Stat Phys 118, 2005), we prove that localized
but otherwise arbitrary perturbations of weakly interacting quantum spin systems
with uniformly gapped on-site terms change the ground state of such a system only
locally, even if they close the spectral gap. We call this a strong version of
the local perturbations perturb locally (LPPL) principle which is known to hold
for much more general gapped systems, but only for perturbations that do not close
the spectral gap of the Hamiltonian. We also extend this strong LPPL-principle
to Hamiltonians that have the appropriate structure of gapped on-site terms and
weak interactions only locally in some region of space. While our results are
technically corollaries to a theorem of Yarotsky, we expect that the paradigm
of systems with a locally gapped ground state that is completely insensitive to
the form of the Hamiltonian elsewhere extends to other situations and has important
physical consequences.
acknowledgement: J. H. acknowledges partial financial support by the ERC Advanced
Grant “RMTBeyond” No. 101020331. S. T. thanks Marius Lemm and Simone Warzel for
very helpful comments and discussions and Jürg Fröhlich for references to the literature.
Open Access funding enabled and organized by Projekt DEAL.
article_number: '9'
article_processing_charge: No
article_type: original
arxiv: 1
author:
- first_name: Sven Joscha
full_name: Henheik, Sven Joscha
id: 31d731d7-d235-11ea-ad11-b50331c8d7fb
last_name: Henheik
orcid: 0000-0003-1106-327X
- first_name: Stefan
full_name: Teufel, Stefan
last_name: Teufel
- first_name: Tom
full_name: Wessel, Tom
last_name: Wessel
citation:
ama: Henheik SJ, Teufel S, Wessel T. Local stability of ground states in locally
gapped and weakly interacting quantum spin systems. Letters in Mathematical
Physics. 2022;112(1). doi:10.1007/s11005-021-01494-y
apa: Henheik, S. J., Teufel, S., & Wessel, T. (2022). Local stability of ground
states in locally gapped and weakly interacting quantum spin systems. Letters
in Mathematical Physics. Springer Nature. https://doi.org/10.1007/s11005-021-01494-y
chicago: Henheik, Sven Joscha, Stefan Teufel, and Tom Wessel. “Local Stability of
Ground States in Locally Gapped and Weakly Interacting Quantum Spin Systems.”
Letters in Mathematical Physics. Springer Nature, 2022. https://doi.org/10.1007/s11005-021-01494-y.
ieee: S. J. Henheik, S. Teufel, and T. Wessel, “Local stability of ground states
in locally gapped and weakly interacting quantum spin systems,” Letters in
Mathematical Physics, vol. 112, no. 1. Springer Nature, 2022.
ista: Henheik SJ, Teufel S, Wessel T. 2022. Local stability of ground states in
locally gapped and weakly interacting quantum spin systems. Letters in Mathematical
Physics. 112(1), 9.
mla: Henheik, Sven Joscha, et al. “Local Stability of Ground States in Locally Gapped
and Weakly Interacting Quantum Spin Systems.” Letters in Mathematical Physics,
vol. 112, no. 1, 9, Springer Nature, 2022, doi:10.1007/s11005-021-01494-y.
short: S.J. Henheik, S. Teufel, T. Wessel, Letters in Mathematical Physics 112 (2022).
date_created: 2022-01-18T16:18:25Z
date_published: 2022-01-18T00:00:00Z
date_updated: 2023-08-02T13:57:02Z
day: '18'
ddc:
- '530'
department:
- _id: GradSch
- _id: LaEr
doi: 10.1007/s11005-021-01494-y
ec_funded: 1
external_id:
arxiv:
- '2106.13780'
isi:
- '000744930400001'
file:
- access_level: open_access
checksum: 7e8e69b76e892c305071a4736131fe18
content_type: application/pdf
creator: cchlebak
date_created: 2022-01-19T09:41:14Z
date_updated: 2022-01-19T09:41:14Z
file_id: '10647'
file_name: 2022_LettersMathPhys_Henheik.pdf
file_size: 357547
relation: main_file
success: 1
file_date_updated: 2022-01-19T09:41:14Z
has_accepted_license: '1'
intvolume: ' 112'
isi: 1
issue: '1'
keyword:
- mathematical physics
- statistical and nonlinear physics
language:
- iso: eng
month: '01'
oa: 1
oa_version: Published Version
project:
- _id: 62796744-2b32-11ec-9570-940b20777f1d
call_identifier: H2020
grant_number: '101020331'
name: Random matrices beyond Wigner-Dyson-Mehta
publication: Letters in Mathematical Physics
publication_identifier:
eissn:
- 1573-0530
issn:
- 0377-9017
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
status: public
title: Local stability of ground states in locally gapped and weakly interacting quantum
spin systems
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 112
year: '2022'
...
---
_id: '10643'
abstract:
- lang: eng
text: "We prove a generalised super-adiabatic theorem for extended fermionic systems
assuming a spectral gap only in the bulk. More precisely, we assume that the infinite
system has a unique ground state and that the corresponding Gelfand–Naimark–Segal
Hamiltonian has a spectral gap above its eigenvalue zero. Moreover, we show that
a similar adiabatic theorem also holds in the bulk of finite systems up to errors
that vanish faster than any inverse power of the system size, although the corresponding
finite-volume Hamiltonians need not have a spectral gap.\r\n\r\n"
acknowledgement: J.H. acknowledges partial financial support by the ERC Advanced Grant
‘RMTBeyond’ No. 101020331. Support for publication costs from the Deutsche Forschungsgemeinschaft
and the Open Access Publishing Fund of the University of Tübingen is gratefully
acknowledged.
article_number: e4
article_processing_charge: Yes
article_type: original
arxiv: 1
author:
- first_name: Sven Joscha
full_name: Henheik, Sven Joscha
id: 31d731d7-d235-11ea-ad11-b50331c8d7fb
last_name: Henheik
orcid: 0000-0003-1106-327X
- first_name: Stefan
full_name: Teufel, Stefan
last_name: Teufel
citation:
ama: 'Henheik SJ, Teufel S. Adiabatic theorem in the thermodynamic limit: Systems
with a gap in the bulk. Forum of Mathematics, Sigma. 2022;10. doi:10.1017/fms.2021.80'
apa: 'Henheik, S. J., & Teufel, S. (2022). Adiabatic theorem in the thermodynamic
limit: Systems with a gap in the bulk. Forum of Mathematics, Sigma. Cambridge
University Press. https://doi.org/10.1017/fms.2021.80'
chicago: 'Henheik, Sven Joscha, and Stefan Teufel. “Adiabatic Theorem in the Thermodynamic
Limit: Systems with a Gap in the Bulk.” Forum of Mathematics, Sigma. Cambridge
University Press, 2022. https://doi.org/10.1017/fms.2021.80.'
ieee: 'S. J. Henheik and S. Teufel, “Adiabatic theorem in the thermodynamic limit:
Systems with a gap in the bulk,” Forum of Mathematics, Sigma, vol. 10.
Cambridge University Press, 2022.'
ista: 'Henheik SJ, Teufel S. 2022. Adiabatic theorem in the thermodynamic limit:
Systems with a gap in the bulk. Forum of Mathematics, Sigma. 10, e4.'
mla: 'Henheik, Sven Joscha, and Stefan Teufel. “Adiabatic Theorem in the Thermodynamic
Limit: Systems with a Gap in the Bulk.” Forum of Mathematics, Sigma, vol.
10, e4, Cambridge University Press, 2022, doi:10.1017/fms.2021.80.'
short: S.J. Henheik, S. Teufel, Forum of Mathematics, Sigma 10 (2022).
date_created: 2022-01-18T16:18:51Z
date_published: 2022-01-18T00:00:00Z
date_updated: 2023-08-02T13:53:11Z
day: '18'
ddc:
- '510'
department:
- _id: GradSch
- _id: LaEr
doi: 10.1017/fms.2021.80
ec_funded: 1
external_id:
arxiv:
- '2012.15239'
isi:
- '000743615000001'
file:
- access_level: open_access
checksum: 87592a755adcef22ea590a99dc728dd3
content_type: application/pdf
creator: cchlebak
date_created: 2022-01-19T09:27:43Z
date_updated: 2022-01-19T09:27:43Z
file_id: '10646'
file_name: 2022_ForumMathSigma_Henheik.pdf
file_size: 705323
relation: main_file
success: 1
file_date_updated: 2022-01-19T09:27:43Z
has_accepted_license: '1'
intvolume: ' 10'
isi: 1
keyword:
- computational mathematics
- discrete mathematics and combinatorics
- geometry and topology
- mathematical physics
- statistics and probability
- algebra and number theory
- theoretical computer science
- analysis
language:
- iso: eng
month: '01'
oa: 1
oa_version: Published Version
project:
- _id: 62796744-2b32-11ec-9570-940b20777f1d
call_identifier: H2020
grant_number: '101020331'
name: Random matrices beyond Wigner-Dyson-Mehta
publication: Forum of Mathematics, Sigma
publication_identifier:
eissn:
- 2050-5094
publication_status: published
publisher: Cambridge University Press
quality_controlled: '1'
status: public
title: 'Adiabatic theorem in the thermodynamic limit: Systems with a gap in the bulk'
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 10
year: '2022'
...
---
_id: '10652'
abstract:
- lang: eng
text: Finding a feasible scheme for testing the quantum mechanical nature of the
gravitational interaction has been attracting an increasing level of attention.
Gravity mediated entanglement generation so far appears to be the key ingredient
for a potential experiment. In a recent proposal [D. Carney et al., PRX Quantum
2, 030330 (2021)] combining an atom interferometer with a low-frequency mechanical
oscillator, a coherence revival test is proposed for verifying this entanglement
generation. With measurements performed only on the atoms, this protocol bypasses
the need for correlation measurements. Here, we explore formulations of such a
protocol, and specifically find that in the envisioned regime of operation with
high thermal excitation, semiclassical models, where there is no concept of entanglement,
also give the same experimental signatures. We elucidate in a fully quantum mechanical
calculation that entanglement is not the source of the revivals in the relevant
parameter regime. We argue that, in its current form, the suggested test is only
relevant if the oscillator is nearly in a pure quantum state, and in this regime
the effects are too small to be measurable. We further discuss potential open
ends. The results highlight the importance and subtleties of explicitly considering
how the quantum case differs from the classical expectations when testing for
the quantum mechanical nature of a physical system.
acknowledgement: O.H. is supported by Institute of Science and Technology Austria.
The author thanks Jess Riedel for discussions.
article_number: '013023'
article_processing_charge: Yes (via OA deal)
article_type: original
author:
- first_name: Onur
full_name: Hosten, Onur
id: 4C02D85E-F248-11E8-B48F-1D18A9856A87
last_name: Hosten
orcid: 0000-0002-2031-204X
citation:
ama: Hosten O. Constraints on probing quantum coherence to infer gravitational entanglement.
Physical Review Research. 2022;4(1). doi:10.1103/PhysRevResearch.4.013023
apa: Hosten, O. (2022). Constraints on probing quantum coherence to infer gravitational
entanglement. Physical Review Research. American Physical Society. https://doi.org/10.1103/PhysRevResearch.4.013023
chicago: Hosten, Onur. “Constraints on Probing Quantum Coherence to Infer Gravitational
Entanglement.” Physical Review Research. American Physical Society, 2022.
https://doi.org/10.1103/PhysRevResearch.4.013023.
ieee: O. Hosten, “Constraints on probing quantum coherence to infer gravitational
entanglement,” Physical Review Research, vol. 4, no. 1. American Physical
Society, 2022.
ista: Hosten O. 2022. Constraints on probing quantum coherence to infer gravitational
entanglement. Physical Review Research. 4(1), 013023.
mla: Hosten, Onur. “Constraints on Probing Quantum Coherence to Infer Gravitational
Entanglement.” Physical Review Research, vol. 4, no. 1, 013023, American
Physical Society, 2022, doi:10.1103/PhysRevResearch.4.013023.
short: O. Hosten, Physical Review Research 4 (2022).
date_created: 2022-01-23T23:01:27Z
date_published: 2022-01-10T00:00:00Z
date_updated: 2022-05-16T11:21:38Z
day: '10'
ddc:
- '530'
department:
- _id: OnHo
doi: 10.1103/PhysRevResearch.4.013023
file:
- access_level: open_access
checksum: 7254d267a0633ca5d63131d345e58686
content_type: application/pdf
creator: cchlebak
date_created: 2022-01-24T11:12:44Z
date_updated: 2022-01-24T11:12:44Z
file_id: '10660'
file_name: 2022_PhysRevResearch_Hosten.pdf
file_size: 236329
relation: main_file
success: 1
file_date_updated: 2022-01-24T11:12:44Z
has_accepted_license: '1'
intvolume: ' 4'
issue: '1'
language:
- iso: eng
month: '01'
oa: 1
oa_version: Published Version
publication: Physical Review Research
publication_identifier:
issn:
- 2643-1564
publication_status: published
publisher: American Physical Society
quality_controlled: '1'
scopus_import: '1'
status: public
title: Constraints on probing quantum coherence to infer gravitational entanglement
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 4
year: '2022'
...
---
_id: '10653'
abstract:
- lang: eng
text: Squall lines are known to be the consequence of the interaction of low-level
shear with cold pools associated with convective downdrafts. Also, as the magnitude
of the shear increases beyond a critical shear, squall lines tend to orient themselves.
The existing literature suggests that this orientation reduces incoming wind shear
to the squall line, and maintains equilibrium between wind shear and cold pool
spreading. Although this theory is widely accepted, very few quantitative studies
have been conducted on supercritical regime especially. Here, we test this hypothesis
with tropical squall lines obtained by imposing a vertical wind shear in cloud
resolving simulations in radiative convective equilibrium. In the sub-critical
regime, squall lines are perpendicular to the shear. In the super-critical regime,
their orientation maintain the equilibrium, supporting existing theories. We also
find that as shear increases, cold pools become more intense. However, this intensification
has little impact on squall line orientation.
acknowledgement: The authors gratefully acknowledge funding from the European Research
Council (ERC) under the European Union's Horizon 2020 research and innovation program
(Project CLUSTER, Grant Agreement No. 805041), and from the PhD fellowship of Ecole
Normale Supérieure de Paris-Saclay. Two supplementary movies are also provided showing
the angle detection method and the squall line of the Usfc = 10 m s−1 simulation.
article_number: e2021GL095184
article_processing_charge: No
article_type: original
author:
- first_name: Sophie
full_name: Abramian, Sophie
last_name: Abramian
- first_name: Caroline J
full_name: Muller, Caroline J
id: f978ccb0-3f7f-11eb-b193-b0e2bd13182b
last_name: Muller
orcid: 0000-0001-5836-5350
- first_name: Camille
full_name: Risi, Camille
last_name: Risi
citation:
ama: Abramian S, Muller CJ, Risi C. Shear-convection interactions and orientation
of tropical squall lines. Geophysical Research Letters. 2022;49(1). doi:10.1029/2021GL095184
apa: Abramian, S., Muller, C. J., & Risi, C. (2022). Shear-convection interactions
and orientation of tropical squall lines. Geophysical Research Letters.
Wiley. https://doi.org/10.1029/2021GL095184
chicago: Abramian, Sophie, Caroline J Muller, and Camille Risi. “Shear-Convection
Interactions and Orientation of Tropical Squall Lines.” Geophysical Research
Letters. Wiley, 2022. https://doi.org/10.1029/2021GL095184.
ieee: S. Abramian, C. J. Muller, and C. Risi, “Shear-convection interactions and
orientation of tropical squall lines,” Geophysical Research Letters, vol.
49, no. 1. Wiley, 2022.
ista: Abramian S, Muller CJ, Risi C. 2022. Shear-convection interactions and orientation
of tropical squall lines. Geophysical Research Letters. 49(1), e2021GL095184.
mla: Abramian, Sophie, et al. “Shear-Convection Interactions and Orientation of
Tropical Squall Lines.” Geophysical Research Letters, vol. 49, no. 1, e2021GL095184,
Wiley, 2022, doi:10.1029/2021GL095184.
short: S. Abramian, C.J. Muller, C. Risi, Geophysical Research Letters 49 (2022).
date_created: 2022-01-23T23:01:27Z
date_published: 2022-01-16T00:00:00Z
date_updated: 2023-08-02T14:00:17Z
day: '16'
ddc:
- '550'
department:
- _id: CaMu
doi: 10.1029/2021GL095184
ec_funded: 1
external_id:
isi:
- '000743989800040'
file:
- access_level: open_access
checksum: 08f88b57b8e409b42e382452cd5f297b
content_type: application/pdf
creator: cchlebak
date_created: 2022-01-24T12:14:41Z
date_updated: 2022-01-24T12:14:41Z
file_id: '10662'
file_name: 2022_GeophysResearchLet_Abramian.pdf
file_size: 1117408
relation: main_file
success: 1
file_date_updated: 2022-01-24T12:14:41Z
has_accepted_license: '1'
intvolume: ' 49'
isi: 1
issue: '1'
language:
- iso: eng
month: '01'
oa: 1
oa_version: Published Version
project:
- _id: 629205d8-2b32-11ec-9570-e1356ff73576
call_identifier: H2020
grant_number: '805041'
name: organization of CLoUdS, and implications of Tropical cyclones and for the
Energetics of the tropics, in current and waRming climate
publication: Geophysical Research Letters
publication_identifier:
eissn:
- 1944-8007
issn:
- 0094-8276
publication_status: published
publisher: Wiley
quality_controlled: '1'
related_material:
link:
- relation: earlier_version
url: https://doi.org/10.1002/essoar.10507697.1
scopus_import: '1'
status: public
title: Shear-convection interactions and orientation of tropical squall lines
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 49
year: '2022'
...
---
_id: '10654'
abstract:
- lang: eng
text: "Directed percolation (DP) has recently emerged as a possible solution to
the century old puzzle surrounding the transition to turbulence. Multiple model
studies reported DP exponents, however, experimental evidence is limited since
the largest possible observation times are orders of magnitude shorter than the
flows’ characteristic timescales. An exception is cylindrical Couette flow where
the limit is not temporal, but rather the realizable system size. We present experiments
in a Couette setup of unprecedented azimuthal and axial aspect ratios. Approaching
the critical point to within less than 0.1% we determine five critical exponents,
all of which are in excellent agreement with the 2+1D DP universality class. The
complex dynamics encountered at \r\nthe onset of turbulence can hence be fully
rationalized within the framework of statistical mechanics."
acknowledged_ssus:
- _id: M-Shop
acknowledgement: "We thank T.Menner, T.Asenov, P. Maier and the Miba machine shop
of IST Austria for their valuable support in all technical aspects. We thank Marc
Avila for comments on the manuscript. This work was supported by a grant from the
Simons Foundation (662960, B.H.). We acknowledge the European Research Council under
the European Union’s Seventh Framework Programme (FP/2007-2013)/ERC Grant Agreement
306589 for financial support. K.A.\r\nacknowledges funding from the Central Research
Development Fund of the University of Bremen, grant number ZF04B /2019/FB04 Avila
Kerstin (”Independent Project for Postdocs”). L.K. was supported by the European
Union’s Horizon 2020 Research and innovation programme under the Marie Sklodowska-Curie
grant agreement No. 754411.\r\n"
article_number: '014502'
article_processing_charge: No
article_type: original
arxiv: 1
author:
- first_name: Lukasz
full_name: Klotz, Lukasz
id: 2C9AF1C2-F248-11E8-B48F-1D18A9856A87
last_name: Klotz
orcid: 0000-0003-1740-7635
- first_name: Grégoire M
full_name: Lemoult, Grégoire M
id: 4787FE80-F248-11E8-B48F-1D18A9856A87
last_name: Lemoult
- first_name: Kerstin
full_name: Avila, Kerstin
last_name: Avila
- first_name: Björn
full_name: Hof, Björn
id: 3A374330-F248-11E8-B48F-1D18A9856A87
last_name: Hof
orcid: 0000-0003-2057-2754
citation:
ama: Klotz L, Lemoult GM, Avila K, Hof B. Phase transition to turbulence in spatially
extended shear flows. Physical Review Letters. 2022;128(1). doi:10.1103/PhysRevLett.128.014502
apa: Klotz, L., Lemoult, G. M., Avila, K., & Hof, B. (2022). Phase transition
to turbulence in spatially extended shear flows. Physical Review Letters.
American Physical Society. https://doi.org/10.1103/PhysRevLett.128.014502
chicago: Klotz, Lukasz, Grégoire M Lemoult, Kerstin Avila, and Björn Hof. “Phase
Transition to Turbulence in Spatially Extended Shear Flows.” Physical Review
Letters. American Physical Society, 2022. https://doi.org/10.1103/PhysRevLett.128.014502.
ieee: L. Klotz, G. M. Lemoult, K. Avila, and B. Hof, “Phase transition to turbulence
in spatially extended shear flows,” Physical Review Letters, vol. 128,
no. 1. American Physical Society, 2022.
ista: Klotz L, Lemoult GM, Avila K, Hof B. 2022. Phase transition to turbulence
in spatially extended shear flows. Physical Review Letters. 128(1), 014502.
mla: Klotz, Lukasz, et al. “Phase Transition to Turbulence in Spatially Extended
Shear Flows.” Physical Review Letters, vol. 128, no. 1, 014502, American
Physical Society, 2022, doi:10.1103/PhysRevLett.128.014502.
short: L. Klotz, G.M. Lemoult, K. Avila, B. Hof, Physical Review Letters 128 (2022).
date_created: 2022-01-23T23:01:28Z
date_published: 2022-01-05T00:00:00Z
date_updated: 2023-08-02T13:59:19Z
day: '05'
department:
- _id: BjHo
doi: 10.1103/PhysRevLett.128.014502
ec_funded: 1
external_id:
arxiv:
- '2111.14894'
isi:
- '000748271700010'
pmid:
- '35061458'
intvolume: ' 128'
isi: 1
issue: '1'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://arxiv.org/abs/2111.14894
month: '01'
oa: 1
oa_version: Preprint
pmid: 1
project:
- _id: 260C2330-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '754411'
name: ISTplus - Postdoctoral Fellowships
- _id: 25152F3A-B435-11E9-9278-68D0E5697425
call_identifier: FP7
grant_number: '306589'
name: Decoding the complexity of turbulence at its origin
- _id: 238598C6-32DE-11EA-91FC-C7463DDC885E
grant_number: '662960'
name: 'Revisiting the Turbulence Problem Using Statistical Mechanics: Experimental
Studies on Transitional and Turbulent Flows'
publication: Physical Review Letters
publication_identifier:
eissn:
- 1079-7114
issn:
- 0031-9007
publication_status: published
publisher: American Physical Society
quality_controlled: '1'
scopus_import: '1'
status: public
title: Phase transition to turbulence in spatially extended shear flows
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 128
year: '2022'
...
---
_id: '10656'
abstract:
- lang: eng
text: Idealized simulations of the tropical atmosphere have predicted that clouds
can spontaneously clump together in space, despite perfectly homogeneous settings.
This phenomenon has been called self-aggregation, and it results in a state where
a moist cloudy region with intense deep convective storms is surrounded by extremely
dry subsiding air devoid of deep clouds. We review here the main findings from
theoretical work and idealized models of this phenomenon, highlighting the physical
processes believed to play a key role in convective self-aggregation. We also
review the growing literature on the importance and implications of this phenomenon
for the tropical atmosphere, notably, for the hydrological cycle and for precipitation
extremes, in our current and in a warming climate.
acknowledgement: C.M. gratefully acknowledges funding from the European Research Council
(ERC) under the European Union's Horizon 2020 research and innovation program (Project
CLUSTER, grant agreement 805041). She also thanks Grand Équipement National de Calcul
Intensif (GENCI), France, for providing access to their computing platforms at Très
Grand Centre de Calcul (TGCC). J.O.H. gratefully acknowledges funding from the Villum
Foundation (grant 13168), the ERC under the Horizon 2020 research and innovation
program (grant 771859), and the Novo Nordisk Foundation's Interdisciplinary Synergy
Program (grant NNF19OC0057374). G.C. gratefully acknowledges the support of the
transregional collaborative research center (SFB/TRR 165) “Waves to Weather” (http://www.wavestoweather.de)
funded by the German Research Foundation (DFG). D.Y. is supported by a Packard Fellowship
in Science and Engineering, the France–Berkeley Fund, Laboratory Directed Research
and Development (LDRD) funding from the Lawrence Berkeley National Laboratory, and
the US Department of Energy, Office of Science, Office of Biological and Environmental
Research, Climate and Environmental Sciences Division, Regional and Global Climate
Modeling Program under award DE-AC02-05CH11231.
article_processing_charge: No
article_type: original
author:
- first_name: Caroline J
full_name: Muller, Caroline J
id: f978ccb0-3f7f-11eb-b193-b0e2bd13182b
last_name: Muller
orcid: 0000-0001-5836-5350
- first_name: Da
full_name: Yang, Da
last_name: Yang
- first_name: George
full_name: Craig, George
last_name: Craig
- first_name: Timothy
full_name: Cronin, Timothy
last_name: Cronin
- first_name: Benjamin
full_name: Fildier, Benjamin
last_name: Fildier
- first_name: Jan O.
full_name: Haerter, Jan O.
last_name: Haerter
- first_name: Cathy
full_name: Hohenegger, Cathy
last_name: Hohenegger
- first_name: Brian
full_name: Mapes, Brian
last_name: Mapes
- first_name: David
full_name: Randall, David
last_name: Randall
- first_name: Sara
full_name: Shamekh, Sara
last_name: Shamekh
- first_name: Steven C.
full_name: Sherwood, Steven C.
last_name: Sherwood
citation:
ama: Muller CJ, Yang D, Craig G, et al. Spontaneous aggregation of convective storms.
Annual Review of Fluid Mechanics. 2022;54:133-157. doi:10.1146/annurev-fluid-022421-011319
apa: Muller, C. J., Yang, D., Craig, G., Cronin, T., Fildier, B., Haerter, J. O.,
… Sherwood, S. C. (2022). Spontaneous aggregation of convective storms. Annual
Review of Fluid Mechanics. Annual Reviews. https://doi.org/10.1146/annurev-fluid-022421-011319
chicago: Muller, Caroline J, Da Yang, George Craig, Timothy Cronin, Benjamin Fildier,
Jan O. Haerter, Cathy Hohenegger, et al. “Spontaneous Aggregation of Convective
Storms.” Annual Review of Fluid Mechanics. Annual Reviews, 2022. https://doi.org/10.1146/annurev-fluid-022421-011319.
ieee: C. J. Muller et al., “Spontaneous aggregation of convective storms,”
Annual Review of Fluid Mechanics, vol. 54. Annual Reviews, pp. 133–157,
2022.
ista: Muller CJ, Yang D, Craig G, Cronin T, Fildier B, Haerter JO, Hohenegger C,
Mapes B, Randall D, Shamekh S, Sherwood SC. 2022. Spontaneous aggregation of convective
storms. Annual Review of Fluid Mechanics. 54, 133–157.
mla: Muller, Caroline J., et al. “Spontaneous Aggregation of Convective Storms.”
Annual Review of Fluid Mechanics, vol. 54, Annual Reviews, 2022, pp. 133–57,
doi:10.1146/annurev-fluid-022421-011319.
short: C.J. Muller, D. Yang, G. Craig, T. Cronin, B. Fildier, J.O. Haerter, C. Hohenegger,
B. Mapes, D. Randall, S. Shamekh, S.C. Sherwood, Annual Review of Fluid Mechanics
54 (2022) 133–157.
date_created: 2022-01-23T23:01:29Z
date_published: 2022-01-01T00:00:00Z
date_updated: 2023-10-03T10:51:07Z
day: '01'
department:
- _id: CaMu
doi: 10.1146/annurev-fluid-022421-011319
ec_funded: 1
external_id:
isi:
- '000794152800006'
intvolume: ' 54'
isi: 1
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://doi.org/10.1146/annurev-fluid-022421-011319
month: '01'
oa: 1
oa_version: Published Version
page: 133-157
project:
- _id: 629205d8-2b32-11ec-9570-e1356ff73576
call_identifier: H2020
grant_number: '805041'
name: organization of CLoUdS, and implications of Tropical cyclones and for the
Energetics of the tropics, in current and waRming climate
publication: Annual Review of Fluid Mechanics
publication_identifier:
eissn:
- 1545-4479
issn:
- 0066-4189
publication_status: published
publisher: Annual Reviews
quality_controlled: '1'
scopus_import: '1'
status: public
title: Spontaneous aggregation of convective storms
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 54
year: '2022'
...
---
_id: '10658'
abstract:
- lang: eng
text: We analyse how migration from a large mainland influences genetic load and
population numbers on an island, in a scenario where fitness-affecting variants
are unconditionally deleterious, and where numbers decline with increasing load.
Our analysis shows that migration can have qualitatively different effects, depending
on the total mutation target and fitness effects of deleterious variants. In particular,
we find that populations exhibit a genetic Allee effect across a wide range of
parameter combinations, when variants are partially recessive, cycling between
low-load (large-population) and high-load (sink) states. Increased migration reduces
load in the sink state (by increasing heterozygosity) but further inflates load
in the large-population state (by hindering purging). We identify various critical
parameter thresholds at which one or other stable state collapses, and discuss
how these thresholds are influenced by the genetic versus demographic effects
of migration. Our analysis is based on a ‘semi-deterministic’ analysis, which
accounts for genetic drift but neglects demographic stochasticity. We also compare
against simulations which account for both demographic stochasticity and drift.
Our results clarify the importance of gene flow as a key determinant of extinction
risk in peripheral populations, even in the absence of ecological gradients. This
article is part of the theme issue ‘Species’ ranges in the face of changing environments
(part I)’.
acknowledgement: This research was partly funded by the Austrian Science Fund (FWF)
(grant no. P-32896B).
article_number: '20210010'
article_processing_charge: No
article_type: original
author:
- first_name: Himani
full_name: Sachdeva, Himani
last_name: Sachdeva
- first_name: Oluwafunmilola O
full_name: Olusanya, Oluwafunmilola O
id: 41AD96DC-F248-11E8-B48F-1D18A9856A87
last_name: Olusanya
orcid: 0000-0003-1971-8314
- first_name: Nicholas H
full_name: Barton, Nicholas H
id: 4880FE40-F248-11E8-B48F-1D18A9856A87
last_name: Barton
orcid: 0000-0002-8548-5240
citation:
ama: 'Sachdeva H, Olusanya OO, Barton NH. Genetic load and extinction in peripheral
populations: The roles of migration, drift and demographic stochasticity. Philosophical
Transactions of the Royal Society B. 2022;377(1846). doi:10.1098/rstb.2021.0010'
apa: 'Sachdeva, H., Olusanya, O. O., & Barton, N. H. (2022). Genetic load and
extinction in peripheral populations: The roles of migration, drift and demographic
stochasticity. Philosophical Transactions of the Royal Society B. The Royal
Society. https://doi.org/10.1098/rstb.2021.0010'
chicago: 'Sachdeva, Himani, Oluwafunmilola O Olusanya, and Nicholas H Barton. “Genetic
Load and Extinction in Peripheral Populations: The Roles of Migration, Drift and
Demographic Stochasticity.” Philosophical Transactions of the Royal Society
B. The Royal Society, 2022. https://doi.org/10.1098/rstb.2021.0010.'
ieee: 'H. Sachdeva, O. O. Olusanya, and N. H. Barton, “Genetic load and extinction
in peripheral populations: The roles of migration, drift and demographic stochasticity,”
Philosophical Transactions of the Royal Society B, vol. 377, no. 1846.
The Royal Society, 2022.'
ista: 'Sachdeva H, Olusanya OO, Barton NH. 2022. Genetic load and extinction in
peripheral populations: The roles of migration, drift and demographic stochasticity.
Philosophical Transactions of the Royal Society B. 377(1846), 20210010.'
mla: 'Sachdeva, Himani, et al. “Genetic Load and Extinction in Peripheral Populations:
The Roles of Migration, Drift and Demographic Stochasticity.” Philosophical
Transactions of the Royal Society B, vol. 377, no. 1846, 20210010, The Royal
Society, 2022, doi:10.1098/rstb.2021.0010.'
short: H. Sachdeva, O.O. Olusanya, N.H. Barton, Philosophical Transactions of the
Royal Society B 377 (2022).
date_created: 2022-01-24T10:34:53Z
date_published: 2022-01-24T00:00:00Z
date_updated: 2025-05-26T09:05:09Z
day: '24'
ddc:
- '576'
department:
- _id: GradSch
- _id: NiBa
doi: 10.1098/rstb.2021.0010
external_id:
isi:
- '000745854300008'
pmid:
- '35067097'
file:
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checksum: 04ca9e2f0e344d680b947f2457df8d0a
content_type: application/pdf
creator: oolusany
date_created: 2022-01-24T10:34:45Z
date_updated: 2022-01-24T10:34:45Z
file_id: '10659'
file_name: rstb.2021.0010.pdf
file_size: 1845792
relation: main_file
file_date_updated: 2022-01-24T10:34:45Z
has_accepted_license: '1'
intvolume: ' 377'
isi: 1
issue: '1846'
language:
- iso: eng
month: '01'
oa: 1
oa_version: Published Version
pmid: 1
project:
- _id: c08d3278-5a5b-11eb-8a69-fdb09b55f4b8
grant_number: P32896
name: Causes and consequences of population fragmentation
publication: Philosophical Transactions of the Royal Society B
publication_identifier:
eissn:
- 1471-2970
issn:
- 0962-8436
publication_status: published
publisher: The Royal Society
quality_controlled: '1'
related_material:
link:
- relation: earlier_version
url: https://doi.org/10.1101/2021.08.05.455207
record:
- id: '14711'
relation: dissertation_contains
status: public
status: public
title: 'Genetic load and extinction in peripheral populations: The roles of migration,
drift and demographic stochasticity'
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 377
year: '2022'
...
---
_id: '10702'
abstract:
- lang: eng
text: 'Background: Blood-based markers of cognitive functioning might provide an
accessible way to track neurodegeneration years prior to clinical manifestation
of cognitive impairment and dementia. Results: Using blood-based epigenome-wide
analyses of general cognitive function, we show that individual differences in
DNA methylation (DNAm) explain 35.0% of the variance in general cognitive function
(g). A DNAm predictor explains ~4% of the variance, independently of a polygenic
score, in two external cohorts. It also associates with circulating levels of
neurology- and inflammation-related proteins, global brain imaging metrics, and
regional cortical volumes. Conclusions: As sample sizes increase, the ability
to assess cognitive function from DNAm data may be informative in settings where
cognitive testing is unreliable or unavailable.'
acknowledgement: 'GS received core support from the Chief Scientist Office of the
Scottish Government Health Directorates (CZD/16/6) and the Scottish Funding Council
(HR03006). Genotyping and DNA methylation profiling of the GS samples was carried
out by the Genetics Core Laboratory at the Edinburgh Clinical Research Facility,
Edinburgh, Scotland, and was funded by the Medical Research Council UK and the Wellcome
Trust (Wellcome Trust Strategic Award STratifying Resilience and Depression Longitudinally
(STRADL; Reference 104036/Z/14/Z). The DNA methylation data assayed for Generation
Scotland was partially funded by a 2018 NARSAD Young Investigator Grant from the
Brain & Behavior Research Foundation (Ref: 27404; awardee: Dr David M Howard) and
by a JMAS SIM fellowship from the Royal College of Physicians of Edinburgh (Awardee:
Dr Heather C Whalley). LBC1936 MRI brain imaging was supported by Medical Research
Council (MRC) grants [G0701120], [G1001245], [MR/M013111/1] and [MR/R024065/1].
Magnetic resonance image acquisition and analyses were conducted at the Brain Research
Imaging Centre, Neuroimaging Sciences, University of Edinburgh (www.bric.ed.ac.uk)
which is part of SINAPSE (Scottish Imaging Network: A Platform for Scientific Excellence)
collaboration (www.sinapse.ac.uk) funded by the Scottish Funding Council and the
Chief Scientist Office. This work was supported by the European Union Horizon 2020
(PHC.03.15, project No 666881), SVDs@Target, the Fondation Leducq Transatlantic
Network of Excellence for the Study of Perivascular Spaces in Small Vessel Disease
[ref no. 16 CVD 05]. We thank the LBC1936 participants and team members who contributed
to these studies. The LBC1936 is supported by Age UK (Disconnected Mind project,
which supports S.E.H.), the Medical Research Council (G0701120, G1001245, MR/M013111/1,
MR/R024065/1) and the University of Edinburgh. Methylation typing of LBC1936 was
supported by the Centre for Cognitive Ageing and Cognitive Epidemiology (Pilot Fund
award), Age UK, The Wellcome Trust Institutional Strategic Support Fund, The University
of Edinburgh, and The University of Queensland. Genotyping was funded by the Biotechnology
and Biological Sciences Research Council (BB/F019394/1). Proteomic analyses in LBC1936
were supported by the Age UK grant and NIH Grants R01AG054628 and R01AG05462802S1.
M.V.H. is funded by the Row Fogo Charitable Trust (Grant no. BROD.FID3668413). J.M.W
is supported by the UK Dementia Research Institute which receives its funding from
DRI Ltd, funded by the UK Medical Research Council, Alzheimers Society and Alzheimers
Research UK. R.F.H., E.L.S.C and D.A.G. are supported by funding from the Wellcome
Trust 4 year PhD in Translational Neuroscience: training the next generation of
basic neuroscientists to embrace clinical research [108890/Z/15/Z]. E.M.T.D. was
supported by the National Institutes of Health (NIH) grants R01AG054628, R01MH120219,
R01HD083613, P2CHD042849 and P30AG066614. S.R.C. was also supported by a National
Institutes of Health (NIH) research grant R01AG054628 and is supported by a Sir
Henry Dale Fellowship jointly funded by the Wellcome Trust and the Royal Society
(Grant Number 221890/Z/20/Z). D.L.Mc.C. and R.E.M. are supported by Alzheimers Research
UK major project grant ARUK/PG2017B/10. R.E.M. is supported by Alzheimer’s Society
major project grant AS-PG-19b-010. This research was funded in whole, or in part,
by Wellcome [104036/Z/14/Z and 108890/Z/15/Z]. For the purpose of open access, the
author has applied a CC BY public copyright licence to any Author Accepted Manuscript
version arising from this submission.'
article_number: '26'
article_processing_charge: No
article_type: original
author:
- first_name: Daniel L.
full_name: McCartney, Daniel L.
last_name: McCartney
- first_name: Robert F.
full_name: Hillary, Robert F.
last_name: Hillary
- first_name: Eleanor L.S.
full_name: Conole, Eleanor L.S.
last_name: Conole
- first_name: Daniel Trejo
full_name: Banos, Daniel Trejo
last_name: Banos
- first_name: Danni A.
full_name: Gadd, Danni A.
last_name: Gadd
- first_name: Rosie M.
full_name: Walker, Rosie M.
last_name: Walker
- first_name: Cliff
full_name: Nangle, Cliff
last_name: Nangle
- first_name: Robin
full_name: Flaig, Robin
last_name: Flaig
- first_name: Archie
full_name: Campbell, Archie
last_name: Campbell
- first_name: Alison D.
full_name: Murray, Alison D.
last_name: Murray
- first_name: Susana Muñoz
full_name: Maniega, Susana Muñoz
last_name: Maniega
- first_name: María Del C.
full_name: Valdés-Hernández, María Del C.
last_name: Valdés-Hernández
- first_name: Mathew A.
full_name: Harris, Mathew A.
last_name: Harris
- first_name: Mark E.
full_name: Bastin, Mark E.
last_name: Bastin
- first_name: Joanna M.
full_name: Wardlaw, Joanna M.
last_name: Wardlaw
- first_name: Sarah E.
full_name: Harris, Sarah E.
last_name: Harris
- first_name: David J.
full_name: Porteous, David J.
last_name: Porteous
- first_name: Elliot M.
full_name: Tucker-Drob, Elliot M.
last_name: Tucker-Drob
- first_name: Andrew M.
full_name: McIntosh, Andrew M.
last_name: McIntosh
- first_name: Kathryn L.
full_name: Evans, Kathryn L.
last_name: Evans
- first_name: Ian J.
full_name: Deary, Ian J.
last_name: Deary
- first_name: Simon R.
full_name: Cox, Simon R.
last_name: Cox
- first_name: Matthew Richard
full_name: Robinson, Matthew Richard
id: E5D42276-F5DA-11E9-8E24-6303E6697425
last_name: Robinson
orcid: 0000-0001-8982-8813
- first_name: Riccardo E.
full_name: Marioni, Riccardo E.
last_name: Marioni
citation:
ama: McCartney DL, Hillary RF, Conole ELS, et al. Blood-based epigenome-wide analyses
of cognitive abilities. Genome Biology. 2022;23(1). doi:10.1186/s13059-021-02596-5
apa: McCartney, D. L., Hillary, R. F., Conole, E. L. S., Banos, D. T., Gadd, D.
A., Walker, R. M., … Marioni, R. E. (2022). Blood-based epigenome-wide analyses
of cognitive abilities. Genome Biology. Springer Nature. https://doi.org/10.1186/s13059-021-02596-5
chicago: McCartney, Daniel L., Robert F. Hillary, Eleanor L.S. Conole, Daniel Trejo
Banos, Danni A. Gadd, Rosie M. Walker, Cliff Nangle, et al. “Blood-Based Epigenome-Wide
Analyses of Cognitive Abilities.” Genome Biology. Springer Nature, 2022.
https://doi.org/10.1186/s13059-021-02596-5.
ieee: D. L. McCartney et al., “Blood-based epigenome-wide analyses of cognitive
abilities,” Genome Biology, vol. 23, no. 1. Springer Nature, 2022.
ista: McCartney DL, Hillary RF, Conole ELS, Banos DT, Gadd DA, Walker RM, Nangle
C, Flaig R, Campbell A, Murray AD, Maniega SM, Valdés-Hernández MDC, Harris MA,
Bastin ME, Wardlaw JM, Harris SE, Porteous DJ, Tucker-Drob EM, McIntosh AM, Evans
KL, Deary IJ, Cox SR, Robinson MR, Marioni RE. 2022. Blood-based epigenome-wide
analyses of cognitive abilities. Genome Biology. 23(1), 26.
mla: McCartney, Daniel L., et al. “Blood-Based Epigenome-Wide Analyses of Cognitive
Abilities.” Genome Biology, vol. 23, no. 1, 26, Springer Nature, 2022,
doi:10.1186/s13059-021-02596-5.
short: D.L. McCartney, R.F. Hillary, E.L.S. Conole, D.T. Banos, D.A. Gadd, R.M.
Walker, C. Nangle, R. Flaig, A. Campbell, A.D. Murray, S.M. Maniega, M.D.C. Valdés-Hernández,
M.A. Harris, M.E. Bastin, J.M. Wardlaw, S.E. Harris, D.J. Porteous, E.M. Tucker-Drob,
A.M. McIntosh, K.L. Evans, I.J. Deary, S.R. Cox, M.R. Robinson, R.E. Marioni,
Genome Biology 23 (2022).
date_created: 2022-01-30T23:01:33Z
date_published: 2022-01-17T00:00:00Z
date_updated: 2023-08-02T14:05:13Z
day: '17'
ddc:
- '570'
department:
- _id: MaRo
doi: 10.1186/s13059-021-02596-5
external_id:
isi:
- '000744358300002'
file:
- access_level: open_access
checksum: 34f10bb2b0594189dcac24d13b691d52
content_type: application/pdf
creator: cchlebak
date_created: 2022-01-31T13:16:05Z
date_updated: 2022-01-31T13:16:05Z
file_id: '10708'
file_name: 2022_GenomeBio_McCartney.pdf
file_size: 1540606
relation: main_file
success: 1
file_date_updated: 2022-01-31T13:16:05Z
has_accepted_license: '1'
intvolume: ' 23'
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issue: '1'
language:
- iso: eng
month: '01'
oa: 1
oa_version: Published Version
project:
- _id: 9B8D11D6-BA93-11EA-9121-9846C619BF3A
grant_number: PCEGP3_181181
name: Improving estimation and prediction of common complex disease risk
publication: Genome Biology
publication_identifier:
eissn:
- 1474-760X
issn:
- 1474-7596
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
related_material:
link:
- relation: earlier_version
url: https://doi.org/10.1101/2021.05.24.21257698
record:
- id: '13072'
relation: research_data
status: public
scopus_import: '1'
status: public
title: Blood-based epigenome-wide analyses of cognitive abilities
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 23
year: '2022'
...
---
_id: '10703'
abstract:
- lang: eng
text: 'When crawling through the body, leukocytes often traverse tissues that are
densely packed with extracellular matrix and other cells, and this raises the
question: How do leukocytes overcome compressive mechanical loads? Here, we show
that the actin cortex of leukocytes is mechanoresponsive and that this responsiveness
requires neither force sensing via the nucleus nor adhesive interactions with
a substrate. Upon global compression of the cell body as well as local indentation
of the plasma membrane, Wiskott-Aldrich syndrome protein (WASp) assembles into
dot-like structures, providing activation platforms for Arp2/3 nucleated actin
patches. These patches locally push against the external load, which can be obstructing
collagen fibers or other cells, and thereby create space to facilitate forward
locomotion. We show in vitro and in vivo that this WASp function is rate limiting
for ameboid leukocyte migration in dense but not in loose environments and is
required for trafficking through diverse tissues such as skin and lymph nodes.'
acknowledged_ssus:
- _id: LifeSc
- _id: Bio
- _id: EM-Fac
acknowledgement: We thank N. Darwish-Miranda, F. Leite, F.P. Assen, and A. Eichner
for advice and help with experiments. We thank J. Renkawitz, E. Kiermaier, A. Juanes
Garcia, and M. Avellaneda for critical reading of the manuscript. We thank M. Driscoll
for advice on fluorescent labeling of collagen gels. This research was supported
by the Scientific Service Units (SSUs) of IST Austria through resources provided
by Molecular Biology Services/Lab Support Facility (LSF)/Bioimaging Facility/Electron
Microscopy Facility. This work was funded by grants from the European Research Council
( CoG 724373 ) and the Austrian Science Foundation (FWF) to M.S. F.G. received funding
from the European Union’s Horizon 2020 research and innovation program under the
Marie Skłodowska-Curie grant agreement no. 747687.
article_processing_charge: No
article_type: original
author:
- first_name: Florian
full_name: Gaertner, Florian
last_name: Gaertner
- first_name: Patricia
full_name: Reis-Rodrigues, Patricia
last_name: Reis-Rodrigues
- first_name: Ingrid
full_name: De Vries, Ingrid
id: 4C7D837E-F248-11E8-B48F-1D18A9856A87
last_name: De Vries
- first_name: Miroslav
full_name: Hons, Miroslav
id: 4167FE56-F248-11E8-B48F-1D18A9856A87
last_name: Hons
orcid: 0000-0002-6625-3348
- first_name: Juan
full_name: Aguilera, Juan
last_name: Aguilera
- first_name: Michael
full_name: Riedl, Michael
id: 3BE60946-F248-11E8-B48F-1D18A9856A87
last_name: Riedl
orcid: 0000-0003-4844-6311
- first_name: Alexander F
full_name: Leithner, Alexander F
id: 3B1B77E4-F248-11E8-B48F-1D18A9856A87
last_name: Leithner
orcid: 0000-0002-1073-744X
- first_name: Saren
full_name: Tasciyan, Saren
id: 4323B49C-F248-11E8-B48F-1D18A9856A87
last_name: Tasciyan
orcid: 0000-0003-1671-393X
- first_name: Aglaja
full_name: Kopf, Aglaja
id: 31DAC7B6-F248-11E8-B48F-1D18A9856A87
last_name: Kopf
orcid: 0000-0002-2187-6656
- first_name: Jack
full_name: Merrin, Jack
id: 4515C308-F248-11E8-B48F-1D18A9856A87
last_name: Merrin
orcid: 0000-0001-5145-4609
- first_name: Vanessa
full_name: Zheden, Vanessa
id: 39C5A68A-F248-11E8-B48F-1D18A9856A87
last_name: Zheden
orcid: 0000-0002-9438-4783
- first_name: Walter
full_name: Kaufmann, Walter
id: 3F99E422-F248-11E8-B48F-1D18A9856A87
last_name: Kaufmann
orcid: 0000-0001-9735-5315
- first_name: Robert
full_name: Hauschild, Robert
id: 4E01D6B4-F248-11E8-B48F-1D18A9856A87
last_name: Hauschild
orcid: 0000-0001-9843-3522
- first_name: Michael K
full_name: Sixt, Michael K
id: 41E9FBEA-F248-11E8-B48F-1D18A9856A87
last_name: Sixt
orcid: 0000-0002-6620-9179
citation:
ama: Gaertner F, Reis-Rodrigues P, de Vries I, et al. WASp triggers mechanosensitive
actin patches to facilitate immune cell migration in dense tissues. Developmental
Cell. 2022;57(1):47-62.e9. doi:10.1016/j.devcel.2021.11.024
apa: Gaertner, F., Reis-Rodrigues, P., de Vries, I., Hons, M., Aguilera, J., Riedl,
M., … Sixt, M. K. (2022). WASp triggers mechanosensitive actin patches to facilitate
immune cell migration in dense tissues. Developmental Cell. Cell Press ;
Elsevier. https://doi.org/10.1016/j.devcel.2021.11.024
chicago: Gaertner, Florian, Patricia Reis-Rodrigues, Ingrid de Vries, Miroslav Hons,
Juan Aguilera, Michael Riedl, Alexander F Leithner, et al. “WASp Triggers Mechanosensitive
Actin Patches to Facilitate Immune Cell Migration in Dense Tissues.” Developmental
Cell. Cell Press ; Elsevier, 2022. https://doi.org/10.1016/j.devcel.2021.11.024.
ieee: F. Gaertner et al., “WASp triggers mechanosensitive actin patches to
facilitate immune cell migration in dense tissues,” Developmental Cell,
vol. 57, no. 1. Cell Press ; Elsevier, p. 47–62.e9, 2022.
ista: Gaertner F, Reis-Rodrigues P, de Vries I, Hons M, Aguilera J, Riedl M, Leithner
AF, Tasciyan S, Kopf A, Merrin J, Zheden V, Kaufmann W, Hauschild R, Sixt MK.
2022. WASp triggers mechanosensitive actin patches to facilitate immune cell migration
in dense tissues. Developmental Cell. 57(1), 47–62.e9.
mla: Gaertner, Florian, et al. “WASp Triggers Mechanosensitive Actin Patches to
Facilitate Immune Cell Migration in Dense Tissues.” Developmental Cell,
vol. 57, no. 1, Cell Press ; Elsevier, 2022, p. 47–62.e9, doi:10.1016/j.devcel.2021.11.024.
short: F. Gaertner, P. Reis-Rodrigues, I. de Vries, M. Hons, J. Aguilera, M. Riedl,
A.F. Leithner, S. Tasciyan, A. Kopf, J. Merrin, V. Zheden, W. Kaufmann, R. Hauschild,
M.K. Sixt, Developmental Cell 57 (2022) 47–62.e9.
date_created: 2022-01-30T23:01:33Z
date_published: 2022-01-10T00:00:00Z
date_updated: 2024-03-25T23:30:12Z
day: '10'
ddc:
- '570'
department:
- _id: MiSi
- _id: EM-Fac
- _id: NanoFab
- _id: BjHo
doi: 10.1016/j.devcel.2021.11.024
ec_funded: 1
external_id:
isi:
- '000768933800005'
pmid:
- '34919802'
intvolume: ' 57'
isi: 1
issue: '1'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://www.sciencedirect.com/science/article/pii/S1534580721009497
month: '01'
oa: 1
oa_version: Published Version
page: 47-62.e9
pmid: 1
project:
- _id: 260AA4E2-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '747687'
name: Mechanical Adaptation of Lamellipodial Actin Networks in Migrating Cells
- _id: 25FE9508-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '724373'
name: Cellular navigation along spatial gradients
publication: Developmental Cell
publication_identifier:
eissn:
- 1878-1551
issn:
- 1534-5807
publication_status: published
publisher: Cell Press ; Elsevier
quality_controlled: '1'
related_material:
record:
- id: '12726'
relation: dissertation_contains
status: public
- id: '14530'
relation: dissertation_contains
status: public
- id: '12401'
relation: dissertation_contains
status: public
scopus_import: '1'
status: public
title: WASp triggers mechanosensitive actin patches to facilitate immune cell migration
in dense tissues
tmp:
image: /images/cc_by_nc_nd.png
legal_code_url: https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode
name: Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
(CC BY-NC-ND 4.0)
short: CC BY-NC-ND (4.0)
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 57
year: '2022'
...
---
_id: '10704'
abstract:
- lang: eng
text: We define and study the existence of very stable Higgs bundles on Riemann
surfaces, how it implies a precise formula for the multiplicity of the very stable
components of the global nilpotent cone and its relationship to mirror symmetry.
The main ingredients are the Bialynicki-Birula theory of C∗-actions on semiprojective
varieties, C∗ characters of indices of C∗-equivariant coherent sheaves, Hecke
transformation for Higgs bundles, relative Fourier–Mukai transform along the Hitchin
fibration, hyperholomorphic structures on universal bundles and cominuscule Higgs
bundles.
acknowledgement: We would like to thank Brian Collier, Davide Gaiotto, Peter Gothen,
Jochen Heinloth, Daniel Huybrechts, Quoc Ho, Joel Kamnitzer, Gérard Laumon, Luca
Migliorini, Alexander Minets, Brent Pym, Peng Shan, Carlos Simpson, András Szenes,
Fernando R. Villegas, Richard Wentworth, Edward Witten and Kōta Yoshioka for interesting
comments and discussions. Most of all we are grateful for a long list of very helpful
comments by the referee. We would also like to thank the organizers of the Summer
School on Higgs bundles in Hamburg in September 2018, where the authors and Richard
Wentworth were giving lectures and where the work in this paper started by considering
the mirror of the Lagrangian upward flows W+E investigated in [17]. The second author
wishes to thank EPSRC and ICMAT for support. Open access funding provided by Institute
of Science and Technology (IST Austria).
article_processing_charge: Yes (via OA deal)
article_type: original
arxiv: 1
author:
- first_name: Tamás
full_name: Hausel, Tamás
id: 4A0666D8-F248-11E8-B48F-1D18A9856A87
last_name: Hausel
- first_name: Nigel
full_name: Hitchin, Nigel
last_name: Hitchin
citation:
ama: Hausel T, Hitchin N. Very stable Higgs bundles, equivariant multiplicity and
mirror symmetry. Inventiones Mathematicae. 2022;228:893-989. doi:10.1007/s00222-021-01093-7
apa: Hausel, T., & Hitchin, N. (2022). Very stable Higgs bundles, equivariant
multiplicity and mirror symmetry. Inventiones Mathematicae. Springer Nature.
https://doi.org/10.1007/s00222-021-01093-7
chicago: Hausel, Tamás, and Nigel Hitchin. “Very Stable Higgs Bundles, Equivariant
Multiplicity and Mirror Symmetry.” Inventiones Mathematicae. Springer Nature,
2022. https://doi.org/10.1007/s00222-021-01093-7.
ieee: T. Hausel and N. Hitchin, “Very stable Higgs bundles, equivariant multiplicity
and mirror symmetry,” Inventiones Mathematicae, vol. 228. Springer Nature,
pp. 893–989, 2022.
ista: Hausel T, Hitchin N. 2022. Very stable Higgs bundles, equivariant multiplicity
and mirror symmetry. Inventiones Mathematicae. 228, 893–989.
mla: Hausel, Tamás, and Nigel Hitchin. “Very Stable Higgs Bundles, Equivariant Multiplicity
and Mirror Symmetry.” Inventiones Mathematicae, vol. 228, Springer Nature,
2022, pp. 893–989, doi:10.1007/s00222-021-01093-7.
short: T. Hausel, N. Hitchin, Inventiones Mathematicae 228 (2022) 893–989.
date_created: 2022-01-30T23:01:34Z
date_published: 2022-05-01T00:00:00Z
date_updated: 2023-08-02T14:03:20Z
day: '01'
ddc:
- '510'
department:
- _id: TaHa
doi: 10.1007/s00222-021-01093-7
external_id:
arxiv:
- '2101.08583'
isi:
- '000745495400001'
file:
- access_level: open_access
checksum: a382ba75acebc9adfb8fe56247cb410e
content_type: application/pdf
creator: dernst
date_created: 2023-02-27T07:30:47Z
date_updated: 2023-02-27T07:30:47Z
file_id: '12687'
file_name: 2022_InventionesMahtematicae_Hausel.pdf
file_size: 1069538
relation: main_file
success: 1
file_date_updated: 2023-02-27T07:30:47Z
has_accepted_license: '1'
intvolume: ' 228'
isi: 1
language:
- iso: eng
month: '05'
oa: 1
oa_version: Published Version
page: 893-989
project:
- _id: B67AFEDC-15C9-11EA-A837-991A96BB2854
name: IST Austria Open Access Fund
publication: Inventiones Mathematicae
publication_identifier:
eissn:
- 1432-1297
issn:
- 0020-9910
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
related_material:
link:
- description: News on the ISTA Website
relation: press_release
url: https://ista.ac.at/en/news/the-tip-of-the-mathematical-iceberg/
scopus_import: '1'
status: public
title: Very stable Higgs bundles, equivariant multiplicity and mirror symmetry
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 228
year: '2022'
...
---
_id: '10705'
abstract:
- lang: eng
text: Although rigidity and jamming transitions have been widely studied in physics
and material science, their importance in a number of biological processes, including
embryo development, tissue homeostasis, wound healing, and disease progression,
has only begun to be recognized in the past few years. The hypothesis that biological
systems can undergo rigidity/jamming transitions is attractive, as it would allow
these systems to change their material properties rapidly and strongly. However,
whether such transitions indeed occur in biological systems, how they are being
regulated, and what their physiological relevance might be, is still being debated.
Here, we review theoretical and experimental advances from the past few years,
focusing on the regulation and role of potential tissue rigidity transitions in
different biological processes.
acknowledgement: We thank present and former members of the Heisenberg and Hannezo
groups, in particular Bernat Corominas-Murtra and Nicoletta Petridou, for helpful
discussions, and Claudia Flandoli for the artwork. We apologize for not being able
to cite a number of highly relevant studies, to stay within the maximum allowed
number of citations.
article_processing_charge: No
article_type: original
author:
- first_name: Edouard B
full_name: Hannezo, Edouard B
id: 3A9DB764-F248-11E8-B48F-1D18A9856A87
last_name: Hannezo
orcid: 0000-0001-6005-1561
- first_name: Carl-Philipp J
full_name: Heisenberg, Carl-Philipp J
id: 39427864-F248-11E8-B48F-1D18A9856A87
last_name: Heisenberg
orcid: 0000-0002-0912-4566
citation:
ama: Hannezo EB, Heisenberg C-PJ. Rigidity transitions in development and disease.
Trends in Cell Biology. 2022;32(5):P433-444. doi:10.1016/j.tcb.2021.12.006
apa: Hannezo, E. B., & Heisenberg, C.-P. J. (2022). Rigidity transitions in
development and disease. Trends in Cell Biology. Cell Press. https://doi.org/10.1016/j.tcb.2021.12.006
chicago: Hannezo, Edouard B, and Carl-Philipp J Heisenberg. “Rigidity Transitions
in Development and Disease.” Trends in Cell Biology. Cell Press, 2022.
https://doi.org/10.1016/j.tcb.2021.12.006.
ieee: E. B. Hannezo and C.-P. J. Heisenberg, “Rigidity transitions in development
and disease,” Trends in Cell Biology, vol. 32, no. 5. Cell Press, pp. P433-444,
2022.
ista: Hannezo EB, Heisenberg C-PJ. 2022. Rigidity transitions in development and
disease. Trends in Cell Biology. 32(5), P433-444.
mla: Hannezo, Edouard B., and Carl-Philipp J. Heisenberg. “Rigidity Transitions
in Development and Disease.” Trends in Cell Biology, vol. 32, no. 5, Cell
Press, 2022, pp. P433-444, doi:10.1016/j.tcb.2021.12.006.
short: E.B. Hannezo, C.-P.J. Heisenberg, Trends in Cell Biology 32 (2022) P433-444.
date_created: 2022-01-30T23:01:34Z
date_published: 2022-05-01T00:00:00Z
date_updated: 2023-08-02T14:03:53Z
day: '01'
department:
- _id: EdHa
- _id: CaHe
doi: 10.1016/j.tcb.2021.12.006
external_id:
isi:
- '000795773900009'
pmid:
- '35058104'
intvolume: ' 32'
isi: 1
issue: '5'
language:
- iso: eng
month: '05'
oa_version: None
page: P433-444
pmid: 1
publication: Trends in Cell Biology
publication_identifier:
eissn:
- 1879-3088
issn:
- 0962-8924
publication_status: published
publisher: Cell Press
quality_controlled: '1'
scopus_import: '1'
status: public
title: Rigidity transitions in development and disease
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 32
year: '2022'
...
---
_id: '10706'
abstract:
- lang: eng
text: This is a collection of problems composed by some participants of the workshop
“Differential Geometry, Billiards, and Geometric Optics” that took place at CIRM
on October 4–8, 2021.
article_processing_charge: No
article_type: original
arxiv: 1
author:
- first_name: Misha
full_name: Bialy, Misha
last_name: Bialy
- first_name: Corentin
full_name: Fiorebe, Corentin
id: 06619f18-9070-11eb-847d-d1ee780bd88b
last_name: Fiorebe
- first_name: Alexey
full_name: Glutsyuk, Alexey
last_name: Glutsyuk
- first_name: Mark
full_name: Levi, Mark
last_name: Levi
- first_name: Alexander
full_name: Plakhov, Alexander
last_name: Plakhov
- first_name: Serge
full_name: Tabachnikov, Serge
last_name: Tabachnikov
citation:
ama: Bialy M, Fiorebe C, Glutsyuk A, Levi M, Plakhov A, Tabachnikov S. Open problems
on billiards and geometric optics. Arnold Mathematical Journal. 2022;8:411-422.
doi:10.1007/s40598-022-00198-y
apa: 'Bialy, M., Fiorebe, C., Glutsyuk, A., Levi, M., Plakhov, A., & Tabachnikov,
S. (2022). Open problems on billiards and geometric optics. Arnold Mathematical
Journal. Hybrid: Springer Nature. https://doi.org/10.1007/s40598-022-00198-y'
chicago: Bialy, Misha, Corentin Fiorebe, Alexey Glutsyuk, Mark Levi, Alexander Plakhov,
and Serge Tabachnikov. “Open Problems on Billiards and Geometric Optics.” Arnold
Mathematical Journal. Springer Nature, 2022. https://doi.org/10.1007/s40598-022-00198-y.
ieee: M. Bialy, C. Fiorebe, A. Glutsyuk, M. Levi, A. Plakhov, and S. Tabachnikov,
“Open problems on billiards and geometric optics,” Arnold Mathematical Journal,
vol. 8. Springer Nature, pp. 411–422, 2022.
ista: Bialy M, Fiorebe C, Glutsyuk A, Levi M, Plakhov A, Tabachnikov S. 2022. Open
problems on billiards and geometric optics. Arnold Mathematical Journal. 8, 411–422.
mla: Bialy, Misha, et al. “Open Problems on Billiards and Geometric Optics.” Arnold
Mathematical Journal, vol. 8, Springer Nature, 2022, pp. 411–22, doi:10.1007/s40598-022-00198-y.
short: M. Bialy, C. Fiorebe, A. Glutsyuk, M. Levi, A. Plakhov, S. Tabachnikov, Arnold
Mathematical Journal 8 (2022) 411–422.
conference:
end_date: 2021-10-08
location: Hybrid
name: 'CIRM: Centre International de Rencontres Mathématiques'
start_date: 2021-10-04
date_created: 2022-01-30T23:01:34Z
date_published: 2022-10-01T00:00:00Z
date_updated: 2023-02-27T07:34:08Z
day: '01'
department:
- _id: VaKa
doi: 10.1007/s40598-022-00198-y
external_id:
arxiv:
- '2110.10750'
intvolume: ' 8'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://arxiv.org/abs/2110.10750
month: '10'
oa: 1
oa_version: Preprint
page: 411-422
publication: Arnold Mathematical Journal
publication_identifier:
eissn:
- 2199-6806
issn:
- 2199-6792
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
related_material:
link:
- relation: earlier_version
url: https://conferences.cirm-math.fr/2383.html
scopus_import: '1'
status: public
title: Open problems on billiards and geometric optics
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 8
year: '2022'
...
---
_id: '10712'
abstract:
- lang: eng
text: Solute carriers are increasingly recognized as participating in a plethora
of pathologies, including cancer. We describe here the involvement of the orphan
solute carrier MFSD1 in the regulation of tumor cell migration. Loss of MFSD1
enabled higher levels of metastasis in a mouse model. We identified an increased
migratory potential in MFSD1-/- tumor cells which was mediated by increased focal
adhesion turn-over, reduced stability of mature inactive β1 integrin, and the
resulting increased integrin activation index. We show that MFSD1 promoted recycling
to the cell surface of endocytosed inactive β1 integrin and thereby protected
β1 integrin from proteolytic degradation; this led to dampening of the integrin
activation index. Furthermore, down-regulation of MFSD1 expression was observed
during early steps of tumorigenesis and higher MFSD1 expression levels correlate
with a better cancer patient prognosis. In sum, we describe a requirement for
endolysosomal MFSD1 in efficient β1 integrin recycling to suppress tumor spread.
acknowledged_ssus:
- _id: Bio
acknowledgement: We thank M. Sixt, A. Leithner, and J. Alanko for helpful advice and
the BioImaging Facility at IST Austria for technical support and assistance. We
thank the Siekhaus Lab for the careful review of the manuscript and their input.
MR and DS were funded by the NO Forschungs- und Bildungsges.m.b.H. (LS16-021) and
IST core funding. MD was funded by Deutsche Forschungsgemeinschaft (DA 1785-1).
article_number: '777634'
article_processing_charge: Yes (via OA deal)
article_type: original
author:
- first_name: Marko
full_name: Roblek, Marko
id: 3047D808-F248-11E8-B48F-1D18A9856A87
last_name: Roblek
orcid: 0000-0001-9588-1389
- first_name: Julia
full_name: Bicher, Julia
id: 3CCBB46E-F248-11E8-B48F-1D18A9856A87
last_name: Bicher
- first_name: Merel
full_name: van Gogh, Merel
last_name: van Gogh
- first_name: Attila
full_name: György, Attila
id: 3BCEDBE0-F248-11E8-B48F-1D18A9856A87
last_name: György
orcid: 0000-0002-1819-198X
- first_name: Rita
full_name: Seeböck, Rita
last_name: Seeböck
- first_name: Bozena
full_name: Szulc, Bozena
last_name: Szulc
- first_name: Markus
full_name: Damme, Markus
last_name: Damme
- first_name: Mariusz
full_name: Olczak, Mariusz
last_name: Olczak
- first_name: Lubor
full_name: Borsig, Lubor
last_name: Borsig
- first_name: Daria E
full_name: Siekhaus, Daria E
id: 3D224B9E-F248-11E8-B48F-1D18A9856A87
last_name: Siekhaus
orcid: 0000-0001-8323-8353
citation:
ama: Roblek M, Bicher J, van Gogh M, et al. The solute carrier MFSD1 decreases β1
integrin’s activation status and thus tumor metastasis. Frontiers in Oncology.
2022;12. doi:10.3389/fonc.2022.777634
apa: Roblek, M., Bicher, J., van Gogh, M., György, A., Seeböck, R., Szulc, B., …
Siekhaus, D. E. (2022). The solute carrier MFSD1 decreases β1 integrin’s activation
status and thus tumor metastasis. Frontiers in Oncology. Frontiers. https://doi.org/10.3389/fonc.2022.777634
chicago: Roblek, Marko, Julia Bicher, Merel van Gogh, Attila György, Rita Seeböck,
Bozena Szulc, Markus Damme, Mariusz Olczak, Lubor Borsig, and Daria E Siekhaus.
“The Solute Carrier MFSD1 Decreases Β1 Integrin’s Activation Status and Thus Tumor
Metastasis.” Frontiers in Oncology. Frontiers, 2022. https://doi.org/10.3389/fonc.2022.777634.
ieee: M. Roblek et al., “The solute carrier MFSD1 decreases β1 integrin’s
activation status and thus tumor metastasis,” Frontiers in Oncology, vol.
12. Frontiers, 2022.
ista: Roblek M, Bicher J, van Gogh M, György A, Seeböck R, Szulc B, Damme M, Olczak
M, Borsig L, Siekhaus DE. 2022. The solute carrier MFSD1 decreases β1 integrin’s
activation status and thus tumor metastasis. Frontiers in Oncology. 12, 777634.
mla: Roblek, Marko, et al. “The Solute Carrier MFSD1 Decreases Β1 Integrin’s Activation
Status and Thus Tumor Metastasis.” Frontiers in Oncology, vol. 12, 777634,
Frontiers, 2022, doi:10.3389/fonc.2022.777634.
short: M. Roblek, J. Bicher, M. van Gogh, A. György, R. Seeböck, B. Szulc, M. Damme,
M. Olczak, L. Borsig, D.E. Siekhaus, Frontiers in Oncology 12 (2022).
date_created: 2022-02-01T10:33:50Z
date_published: 2022-02-08T00:00:00Z
date_updated: 2023-08-02T14:05:44Z
day: '08'
ddc:
- '570'
department:
- _id: DaSi
doi: 10.3389/fonc.2022.777634
external_id:
isi:
- '000760618800001'
file:
- access_level: open_access
checksum: 63dfecf30c5bbf9408b3512bd603f78c
content_type: application/pdf
creator: cchlebak
date_created: 2022-02-08T13:26:40Z
date_updated: 2022-02-08T13:26:40Z
file_id: '10751'
file_name: 2022_FrontiersOncol_Roblek.pdf
file_size: 6303227
relation: main_file
success: 1
file_date_updated: 2022-02-08T13:26:40Z
has_accepted_license: '1'
intvolume: ' 12'
isi: 1
language:
- iso: eng
month: '02'
oa: 1
oa_version: Published Version
project:
- _id: 2637E9C0-B435-11E9-9278-68D0E5697425
grant_number: 'LSC16-021 '
name: Investigating the role of the novel major superfamily facilitator transporter
family member MFSD1 in metastasis
publication: Frontiers in Oncology
publication_identifier:
issn:
- 2234-943X
publication_status: published
publisher: Frontiers
quality_controlled: '1'
related_material:
link:
- description: News on IST Homepage
relation: confirmation
url: https://ist.ac.at/en/news/suppressing-the-spread-of-tumors/
scopus_import: '1'
status: public
title: The solute carrier MFSD1 decreases β1 integrin’s activation status and thus
tumor metastasis
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 12
year: '2022'
...
---
_id: '10713'
abstract:
- lang: eng
text: Cells migrate through crowded microenvironments within tissues during normal
development, immune response, and cancer metastasis. Although migration through
pores and tracks in the extracellular matrix (ECM) has been well studied, little
is known about cellular traversal into confining cell-dense tissues. We find that
embryonic tissue invasion by Drosophila macrophages requires division of an epithelial
ectodermal cell at the site of entry. Dividing ectodermal cells disassemble ECM
attachment formed by integrin-mediated focal adhesions next to mesodermal cells,
allowing macrophages to move their nuclei ahead and invade between two immediately
adjacent tissues. Invasion efficiency depends on division frequency, but reduction
of adhesion strength allows macrophage entry independently of division. This work
demonstrates that tissue dynamics can regulate cellular infiltration.
acknowledged_ssus:
- _id: Bio
acknowledgement: 'We thank J. Friml, C. Guet, T. Hurd, M. Fendrych and members of
the laboratory for comments on the manuscript; the Bioimaging Facility of IST Austria
for excellent support and T. Lecuit, E. Hafen, R. Levayer and A. Martin for fly
strains. This work was supported by a grant from the Austrian Science Fund FWF:
Lise Meitner Fellowship M2379-B28 to M.A and D.S., and internal funding from IST
Austria to D.S. and EMBL to S.D.R.'
article_processing_charge: No
article_type: original
author:
- first_name: Maria
full_name: Akhmanova, Maria
id: 3425EC26-F248-11E8-B48F-1D18A9856A87
last_name: Akhmanova
orcid: 0000-0003-1522-3162
- first_name: Shamsi
full_name: Emtenani, Shamsi
id: 49D32318-F248-11E8-B48F-1D18A9856A87
last_name: Emtenani
orcid: 0000-0001-6981-6938
- first_name: Daniel
full_name: Krueger, Daniel
last_name: Krueger
- first_name: Attila
full_name: György, Attila
id: 3BCEDBE0-F248-11E8-B48F-1D18A9856A87
last_name: György
orcid: 0000-0002-1819-198X
- first_name: Mariana
full_name: Pereira Guarda, Mariana
id: 6de81d9d-e2f2-11eb-945a-af8bc2a60b26
last_name: Pereira Guarda
- first_name: Mikhail
full_name: Vlasov, Mikhail
last_name: Vlasov
- first_name: Fedor
full_name: Vlasov, Fedor
last_name: Vlasov
- first_name: Andrei
full_name: Akopian, Andrei
last_name: Akopian
- first_name: Aparna
full_name: Ratheesh, Aparna
id: 2F064CFE-F248-11E8-B48F-1D18A9856A87
last_name: Ratheesh
- first_name: Stefano
full_name: De Renzis, Stefano
last_name: De Renzis
- first_name: Daria E
full_name: Siekhaus, Daria E
id: 3D224B9E-F248-11E8-B48F-1D18A9856A87
last_name: Siekhaus
orcid: 0000-0001-8323-8353
citation:
ama: Akhmanova M, Emtenani S, Krueger D, et al. Cell division in tissues enables
macrophage infiltration. Science. 2022;376(6591):394-396. doi:10.1126/science.abj0425
apa: Akhmanova, M., Emtenani, S., Krueger, D., György, A., Pereira Guarda, M., Vlasov,
M., … Siekhaus, D. E. (2022). Cell division in tissues enables macrophage infiltration.
Science. American Association for the Advancement of Science. https://doi.org/10.1126/science.abj0425
chicago: Akhmanova, Maria, Shamsi Emtenani, Daniel Krueger, Attila György, Mariana
Pereira Guarda, Mikhail Vlasov, Fedor Vlasov, et al. “Cell Division in Tissues
Enables Macrophage Infiltration.” Science. American Association for the
Advancement of Science, 2022. https://doi.org/10.1126/science.abj0425.
ieee: M. Akhmanova et al., “Cell division in tissues enables macrophage infiltration,”
Science, vol. 376, no. 6591. American Association for the Advancement of
Science, pp. 394–396, 2022.
ista: Akhmanova M, Emtenani S, Krueger D, György A, Pereira Guarda M, Vlasov M,
Vlasov F, Akopian A, Ratheesh A, De Renzis S, Siekhaus DE. 2022. Cell division
in tissues enables macrophage infiltration. Science. 376(6591), 394–396.
mla: Akhmanova, Maria, et al. “Cell Division in Tissues Enables Macrophage Infiltration.”
Science, vol. 376, no. 6591, American Association for the Advancement of
Science, 2022, pp. 394–96, doi:10.1126/science.abj0425.
short: M. Akhmanova, S. Emtenani, D. Krueger, A. György, M. Pereira Guarda, M. Vlasov,
F. Vlasov, A. Akopian, A. Ratheesh, S. De Renzis, D.E. Siekhaus, Science 376 (2022)
394–396.
date_created: 2022-02-01T11:23:18Z
date_published: 2022-04-22T00:00:00Z
date_updated: 2023-08-02T14:06:15Z
day: '22'
department:
- _id: DaSi
doi: 10.1126/science.abj0425
external_id:
isi:
- '000788553700039'
pmid:
- '35446632'
intvolume: ' 376'
isi: 1
issue: '6591'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://doi.org/10.1101/2021.04.19.438995
month: '04'
oa: 1
oa_version: Preprint
page: 394-396
pmid: 1
project:
- _id: 264CBBAC-B435-11E9-9278-68D0E5697425
call_identifier: FWF
grant_number: M02379
name: Modeling epithelial tissue mechanics during cell invasion
publication: Science
publication_identifier:
issn:
- 0036-8075
publication_status: published
publisher: American Association for the Advancement of Science
quality_controlled: '1'
status: public
title: Cell division in tissues enables macrophage infiltration
tmp:
image: /images/cc_by_nc_nd.png
legal_code_url: https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode
name: Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
(CC BY-NC-ND 4.0)
short: CC BY-NC-ND (4.0)
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 376
year: '2022'
...
---
_id: '10714'
abstract:
- lang: eng
text: Ribosomal defects perturb stem cell differentiation, causing diseases called
ribosomopathies. How ribosome levels control stem cell differentiation is not
fully known. Here, we discovered three RNA helicases are required for ribosome
biogenesis and for Drosophila oogenesis. Loss of these helicases, which we named
Aramis, Athos and Porthos, lead to aberrant stabilization of p53, cell cycle arrest
and stalled GSC differentiation. Unexpectedly, Aramis is required for efficient
translation of a cohort of mRNAs containing a 5’-Terminal-Oligo-Pyrimidine (TOP)-motif,
including mRNAs that encode ribosomal proteins and a conserved p53 inhibitor,
Novel Nucleolar protein 1 (Non1). The TOP-motif co-regulates the translation of
growth-related mRNAs in mammals. As in mammals, the La-related protein co-regulates
the translation of TOP-motif containing RNAs during Drosophila oogenesis. Thus,
a previously unappreciated TOP-motif in Drosophila responds to reduced ribosome
biogenesis to co-regulate the translation of ribosomal proteins and a p53 repressor,
thus coupling ribosome biogenesis to GSC differentiation.
acknowledgement: We are grateful to all members of the Rangan and Fuchs labs for their
discussion and comments on the manuscript. We also thanks Dr. Sammons, Dr. Marlow,
Life Science Editors, for their thoughts and comments the manuscript Additionally,
we thank the Bloomington Stock Center, the Vienna Drosophila Resource Center, the
BDGP Gene Disruption Project, and Flybase for fly stocks, reagents, and other resources.
P.R. is funded by the NIH/NIGMS (R01GM111779-06 and RO1GM135628-01), G.F. is funded
by NSF MCB-2047629 and NIH RO3 AI144839, D.E.S. was funded by Marie Curie CIG 334077/IRTIM
and the Austrian Science Fund (FWF) grant ASI_FWF01_P29638S, and A.B is funded by
NIH R01GM116889 and American Cancer Society RSG-17-197-01-RMC.
article_processing_charge: No
article_type: original
author:
- first_name: Elliot T.
full_name: Martin, Elliot T.
last_name: Martin
- first_name: Patrick
full_name: Blatt, Patrick
last_name: Blatt
- first_name: Elaine
full_name: Ngyuen, Elaine
last_name: Ngyuen
- first_name: Roni
full_name: Lahr, Roni
last_name: Lahr
- first_name: Sangeetha
full_name: Selvam, Sangeetha
last_name: Selvam
- first_name: Hyun Ah M.
full_name: Yoon, Hyun Ah M.
last_name: Yoon
- first_name: Tyler
full_name: Pocchiari, Tyler
last_name: Pocchiari
- first_name: Shamsi
full_name: Emtenani, Shamsi
id: 49D32318-F248-11E8-B48F-1D18A9856A87
last_name: Emtenani
orcid: 0000-0001-6981-6938
- first_name: Daria E
full_name: Siekhaus, Daria E
id: 3D224B9E-F248-11E8-B48F-1D18A9856A87
last_name: Siekhaus
orcid: 0000-0001-8323-8353
- first_name: Andrea
full_name: Berman, Andrea
last_name: Berman
- first_name: Gabriele
full_name: Fuchs, Gabriele
last_name: Fuchs
- first_name: Prashanth
full_name: Rangan, Prashanth
last_name: Rangan
citation:
ama: Martin ET, Blatt P, Ngyuen E, et al. A translation control module coordinates
germline stem cell differentiation with ribosome biogenesis during Drosophila
oogenesis. Developmental Cell. 2022;57(7):883-900.e10. doi:10.1016/j.devcel.2022.03.005
apa: Martin, E. T., Blatt, P., Ngyuen, E., Lahr, R., Selvam, S., Yoon, H. A. M.,
… Rangan, P. (2022). A translation control module coordinates germline stem cell
differentiation with ribosome biogenesis during Drosophila oogenesis. Developmental
Cell. Elsevier. https://doi.org/10.1016/j.devcel.2022.03.005
chicago: Martin, Elliot T., Patrick Blatt, Elaine Ngyuen, Roni Lahr, Sangeetha Selvam,
Hyun Ah M. Yoon, Tyler Pocchiari, et al. “A Translation Control Module Coordinates
Germline Stem Cell Differentiation with Ribosome Biogenesis during Drosophila
Oogenesis.” Developmental Cell. Elsevier, 2022. https://doi.org/10.1016/j.devcel.2022.03.005.
ieee: E. T. Martin et al., “A translation control module coordinates germline
stem cell differentiation with ribosome biogenesis during Drosophila oogenesis,”
Developmental Cell, vol. 57, no. 7. Elsevier, p. 883–900.e10, 2022.
ista: Martin ET, Blatt P, Ngyuen E, Lahr R, Selvam S, Yoon HAM, Pocchiari T, Emtenani
S, Siekhaus DE, Berman A, Fuchs G, Rangan P. 2022. A translation control module
coordinates germline stem cell differentiation with ribosome biogenesis during
Drosophila oogenesis. Developmental Cell. 57(7), 883–900.e10.
mla: Martin, Elliot T., et al. “A Translation Control Module Coordinates Germline
Stem Cell Differentiation with Ribosome Biogenesis during Drosophila Oogenesis.”
Developmental Cell, vol. 57, no. 7, Elsevier, 2022, p. 883–900.e10, doi:10.1016/j.devcel.2022.03.005.
short: E.T. Martin, P. Blatt, E. Ngyuen, R. Lahr, S. Selvam, H.A.M. Yoon, T. Pocchiari,
S. Emtenani, D.E. Siekhaus, A. Berman, G. Fuchs, P. Rangan, Developmental Cell
57 (2022) 883–900.e10.
date_created: 2022-02-01T13:15:05Z
date_published: 2022-04-11T00:00:00Z
date_updated: 2023-08-02T14:07:13Z
day: '11'
department:
- _id: DaSi
doi: 10.1016/j.devcel.2022.03.005
ec_funded: 1
external_id:
isi:
- '000789021800005'
intvolume: ' 57'
isi: 1
issue: '7'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://doi.org/10.1101/2021.04.04.438367
month: '04'
oa: 1
oa_version: Preprint
page: 883-900.e10
project:
- _id: 2536F660-B435-11E9-9278-68D0E5697425
call_identifier: FP7
grant_number: '334077'
name: Investigating the role of transporters in invasive migration through junctions
- _id: 253B6E48-B435-11E9-9278-68D0E5697425
call_identifier: FWF
grant_number: P29638
name: Drosophila TNFa´s Funktion in Immunzellen
publication: Developmental Cell
publication_identifier:
eissn:
- 1878-1551
issn:
- 1534-5807
publication_status: published
publisher: Elsevier
quality_controlled: '1'
scopus_import: '1'
status: public
title: A translation control module coordinates germline stem cell differentiation
with ribosome biogenesis during Drosophila oogenesis
tmp:
image: /images/cc_by_nc_nd.png
legal_code_url: https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode
name: Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
(CC BY-NC-ND 4.0)
short: CC BY-NC-ND (4.0)
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 57
year: '2022'
...
---
_id: '10717'
abstract:
- lang: eng
text: Much of what we know about the role of auxin in plant development derives
from exogenous manipulations of auxin distribution and signaling, using inhibitors,
auxins and auxin analogs. In this context, synthetic auxin analogs, such as 1-Naphtalene
Acetic Acid (1-NAA), are often favored over the endogenous auxin indole-3-acetic
acid (IAA), in part due to their higher stability. While such auxin analogs have
proven to be instrumental to reveal the various faces of auxin, they display in
some cases distinct bioactivities compared to IAA. Here, we focused on the effect
of auxin analogs on the accumulation of PIN proteins in Brefeldin A-sensitive
endosomal aggregations (BFA bodies), and the correlation with the ability to elicit
Ca 2+ responses. For a set of commonly used auxin analogs, we evaluated if auxin-analog
induced Ca 2+ signaling inhibits PIN accumulation. Not all auxin analogs elicited
a Ca 2+ response, and their differential ability to elicit Ca 2+ responses correlated
partially with their ability to inhibit BFA-body formation. However, in tir1/afb
and cngc14, 1-NAA-induced Ca 2+ signaling was strongly impaired, yet 1-NAA still
could inhibit PIN accumulation in BFA bodies. This demonstrates that TIR1/AFB-CNGC14-dependent
Ca 2+ signaling does not inhibit BFA body formation in Arabidopsis roots.
acknowledgement: "We thank Joerg Kudla (WWU Munster, Germany), Petra Dietrich (F.A.
University of Erlangen-Nurnberg, Germany) for sharing published materials, and NASC
for providing seeds. We thank Veronique Storme for help with the statistical analyses.
Part of the imaging analysis was carried out at NOLIMITS, an advanced imaging facility
established by the University of Milan.\r\nThis work was supported by grants of
the China Scholarship Council (CSC) to RW and JC; Fonds Wetenschappelijk Onderzoek
(FWO) to TB and (G002220N) SV; the special research fund of Ghent University to
EH; the Deutsche Forschungsgemeinschaft (DFG) through Grants within FOR964 (MK and
KS); Piano di Sviluppo di Ateneo 2019 (University of Milan) to AC; the European
Research Council (ERC) T-Rex project 682436 to DVD; the ERC ETAP project 742985
to JF, and by a PhD fellowship from the University of Milan to MG."
article_number: erac019
article_processing_charge: No
article_type: original
author:
- first_name: R
full_name: Wang, R
last_name: Wang
- first_name: E
full_name: Himschoot, E
last_name: Himschoot
- first_name: M
full_name: Grenzi, M
last_name: Grenzi
- first_name: J
full_name: Chen, J
last_name: Chen
- first_name: A
full_name: Safi, A
last_name: Safi
- first_name: M
full_name: Krebs, M
last_name: Krebs
- first_name: K
full_name: Schumacher, K
last_name: Schumacher
- first_name: MK
full_name: Nowack, MK
last_name: Nowack
- first_name: W
full_name: Moeder, W
last_name: Moeder
- first_name: K
full_name: Yoshioka, K
last_name: Yoshioka
- first_name: D
full_name: Van Damme, D
last_name: Van Damme
- first_name: I
full_name: De Smet, I
last_name: De Smet
- first_name: D
full_name: Geelen, D
last_name: Geelen
- first_name: T
full_name: Beeckman, T
last_name: Beeckman
- first_name: Jiří
full_name: Friml, Jiří
id: 4159519E-F248-11E8-B48F-1D18A9856A87
last_name: Friml
orcid: 0000-0002-8302-7596
- first_name: A
full_name: Costa, A
last_name: Costa
- first_name: S
full_name: Vanneste, S
last_name: Vanneste
citation:
ama: Wang R, Himschoot E, Grenzi M, et al. Auxin analog-induced Ca2+ signaling is
independent of inhibition of endosomal aggregation in Arabidopsis roots. Journal
of Experimental Botany. 2022;73(8). doi:10.1093/jxb/erac019
apa: Wang, R., Himschoot, E., Grenzi, M., Chen, J., Safi, A., Krebs, M., … Vanneste,
S. (2022). Auxin analog-induced Ca2+ signaling is independent of inhibition of
endosomal aggregation in Arabidopsis roots. Journal of Experimental Botany.
Oxford Academic. https://doi.org/10.1093/jxb/erac019
chicago: Wang, R, E Himschoot, M Grenzi, J Chen, A Safi, M Krebs, K Schumacher,
et al. “Auxin Analog-Induced Ca2+ Signaling Is Independent of Inhibition of Endosomal
Aggregation in Arabidopsis Roots.” Journal of Experimental Botany. Oxford
Academic, 2022. https://doi.org/10.1093/jxb/erac019.
ieee: R. Wang et al., “Auxin analog-induced Ca2+ signaling is independent
of inhibition of endosomal aggregation in Arabidopsis roots,” Journal of Experimental
Botany, vol. 73, no. 8. Oxford Academic, 2022.
ista: Wang R, Himschoot E, Grenzi M, Chen J, Safi A, Krebs M, Schumacher K, Nowack
M, Moeder W, Yoshioka K, Van Damme D, De Smet I, Geelen D, Beeckman T, Friml J,
Costa A, Vanneste S. 2022. Auxin analog-induced Ca2+ signaling is independent
of inhibition of endosomal aggregation in Arabidopsis roots. Journal of Experimental
Botany. 73(8), erac019.
mla: Wang, R., et al. “Auxin Analog-Induced Ca2+ Signaling Is Independent of Inhibition
of Endosomal Aggregation in Arabidopsis Roots.” Journal of Experimental Botany,
vol. 73, no. 8, erac019, Oxford Academic, 2022, doi:10.1093/jxb/erac019.
short: R. Wang, E. Himschoot, M. Grenzi, J. Chen, A. Safi, M. Krebs, K. Schumacher,
M. Nowack, W. Moeder, K. Yoshioka, D. Van Damme, I. De Smet, D. Geelen, T. Beeckman,
J. Friml, A. Costa, S. Vanneste, Journal of Experimental Botany 73 (2022).
date_created: 2022-02-03T09:19:01Z
date_published: 2022-04-18T00:00:00Z
date_updated: 2023-08-02T14:07:58Z
day: '18'
department:
- _id: JiFr
doi: 10.1093/jxb/erac019
ec_funded: 1
external_id:
isi:
- '000764220900001'
pmid:
- '35085386'
intvolume: ' 73'
isi: 1
issue: '8'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://biblio.ugent.be/publication/8738721
month: '04'
oa: 1
oa_version: Submitted Version
pmid: 1
project:
- _id: 261099A6-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '742985'
name: Tracing Evolution of Auxin Transport and Polarity in Plants
publication: Journal of Experimental Botany
publication_identifier:
eissn:
- 1460-2431
issn:
- 0022-0957
publication_status: published
publisher: Oxford Academic
quality_controlled: '1'
scopus_import: '1'
status: public
title: Auxin analog-induced Ca2+ signaling is independent of inhibition of endosomal
aggregation in Arabidopsis roots
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 73
year: '2022'
...
---
_id: '10719'
abstract:
- lang: eng
text: Auxin, one of the first identified and most widely studied phytohormones,
has been and will remain a hot topic in plant biology. After more than a century
of passionate exploration, the mysteries of its synthesis, transport, signaling,
and metabolism have largely been unlocked. Due to the rapid development of new
technologies, new methods, and new genetic materials, the study of auxin has entered
the fast lane over the past 30 years. Here, we highlight advances in understanding
auxin signaling, including auxin perception, rapid auxin responses, TRANSPORT
INHIBITOR RESPONSE 1 and AUXIN SIGNALING F-boxes (TIR1/AFBs)-mediated transcriptional
and non-transcriptional branches, and the epigenetic regulation of auxin signaling.
We also focus on feedback inhibition mechanisms that prevent the over-amplification
of auxin signals. In addition, we cover the TRANSMEMBRANE KINASEs (TMKs)-mediated
non-canonical signaling, which converges with TIR1/AFBs-mediated transcriptional
regulation to coordinate plant growth and development. The identification of additional
auxin signaling components and their regulation will continue to open new avenues
of research in this field, leading to an increasingly deeper, more comprehensive
understanding of how auxin signals are interpreted at the cellular level to regulate
plant growth and development.
acknowledgement: "This research was financially supported by the National Natural
Science Foundation of China and the Israel Science Foundation (NSFC-ISF; 32061143005),
National Natural Science Foundation of China (32000225), Natural Science Foundation
of Shandong Province (ZR2020QC036), and China Postdoctoral Science Foundation (2020M682165).\r\n"
article_processing_charge: No
article_type: review
author:
- first_name: Z
full_name: Yu, Z
last_name: Yu
- first_name: F
full_name: Zhang, F
last_name: Zhang
- first_name: Jiří
full_name: Friml, Jiří
id: 4159519E-F248-11E8-B48F-1D18A9856A87
last_name: Friml
orcid: 0000-0002-8302-7596
- first_name: Z
full_name: Ding, Z
last_name: Ding
citation:
ama: 'Yu Z, Zhang F, Friml J, Ding Z. Auxin signaling: Research advances over the
past 30 years. Journal of Integrative Plant Biology. 2022;64(2):371-392.
doi:10.1111/jipb.13225'
apa: 'Yu, Z., Zhang, F., Friml, J., & Ding, Z. (2022). Auxin signaling: Research
advances over the past 30 years. Journal of Integrative Plant Biology.
Wiley. https://doi.org/10.1111/jipb.13225'
chicago: 'Yu, Z, F Zhang, Jiří Friml, and Z Ding. “Auxin Signaling: Research Advances
over the Past 30 Years.” Journal of Integrative Plant Biology. Wiley, 2022.
https://doi.org/10.1111/jipb.13225.'
ieee: 'Z. Yu, F. Zhang, J. Friml, and Z. Ding, “Auxin signaling: Research advances
over the past 30 years,” Journal of Integrative Plant Biology, vol. 64,
no. 2. Wiley, pp. 371–392, 2022.'
ista: 'Yu Z, Zhang F, Friml J, Ding Z. 2022. Auxin signaling: Research advances
over the past 30 years. Journal of Integrative Plant Biology. 64(2), 371–392.'
mla: 'Yu, Z., et al. “Auxin Signaling: Research Advances over the Past 30 Years.”
Journal of Integrative Plant Biology, vol. 64, no. 2, Wiley, 2022, pp.
371–92, doi:10.1111/jipb.13225.'
short: Z. Yu, F. Zhang, J. Friml, Z. Ding, Journal of Integrative Plant Biology
64 (2022) 371–392.
date_created: 2022-02-03T09:52:59Z
date_published: 2022-02-01T00:00:00Z
date_updated: 2023-08-02T14:08:30Z
day: '01'
department:
- _id: JiFr
doi: 10.1111/jipb.13225
external_id:
isi:
- '000761281200011'
pmid:
- '35018726'
intvolume: ' 64'
isi: 1
issue: '2'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://doi.org/10.1111/jipb.13225
month: '02'
oa: 1
oa_version: Published Version
page: 371-392
pmid: 1
publication: Journal of Integrative Plant Biology
publication_identifier:
eissn:
- 1744-7909
issn:
- 1672-9072
publication_status: published
publisher: Wiley
quality_controlled: '1'
scopus_import: '1'
status: public
title: 'Auxin signaling: Research advances over the past 30 years'
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 64
year: '2022'
...
---
_id: '10727'
abstract:
- lang: eng
text: "Social insects are a common model to study disease dynamics in social animals.
Even though pathogens should thrive in social insect colonies as the hosts engage
in frequent social interactions, are closely related and live in a pathogen-rich
environment, disease outbreaks are rare. This is because social insects have evolved
mechanisms to keep pathogens at bay – and fight disease as a collective. Social
insect colonies are often viewed as “superorganisms” with division of labor between
reproductive “germ-like” queens and males and “somatic” workers, which together
form an interdependent reproductive unit that parallels a multicellular body.
Superorganisms possess a “social immune system” that comprises of collective disease
defenses performed by the workers - summarized as “social immunity”. In social
groups immunization (reduced susceptibility to a parasite upon secondary exposure
to the same parasite) can e.g. be triggered by social interactions (“social immunization”).
Social immunization can be caused by (i) asymptomatic low-level infections that
are acquired during caregiving to a contagious individual that can give an immune
boost, which can induce protection upon later encounter with the same pathogen
(active immunization) or (ii) by transfer of immune effectors between individuals
(passive immunization).\r\nIn the second chapter, I built up on a study that I
co-authored that found that low-level infections can not only be protective, but
also be costly and make the host more susceptible to detrimental superinfections
after contact to a very dissimilar pathogen. I here now tested different degrees
of phylogenetically-distant fungal strains of M. brunneum and M. robertsii in
L. neglectus and can describe the occurrence of cross-protection of social immunization
if the first and second pathogen are from the same level. Interestingly, low-level
infections only provided protection when the first strain was less virulent than
the second strain and elicited higher immune gene expression.\r\nIn the third
and fourth chapters, I expanded on the role of social immunity in sexual selection,
a so far unstudied field. I used the fungus Metarhizium robertsii and the ant
Cardiocondyla obscurior as a model, as in this species mating occurs in the presence
of workers and can be studied under laboratory conditions. Before males mate with
virgin queens in the nest they engage in fierce combat over the access to their
mating partners.\r\nFirst, I focused on male-male competition in the third chapter
and found that fighting with a contagious male is costly as it can lead to contamination
of the rival, but that workers can decrease the risk of disease contraction by
performing sanitary care.\r\nIn the fourth chapter, I studied the effect of fungal
infection on survival and mating success of sexuals (freshly emerged queens and
males) and found that worker-performed sanitary care can buffer the negative effect
that a pathogenic contagion would have on sexuals by spore removal from the exposed
individuals. When social immunity was prevented and queens could contract spores
from their mating partner, very low dosages led to negative consequences: their
lifespan was reduced and they produced fewer offspring with poor immunocompetence
compared to healthy queens. Interestingly, cohabitation with a late-stage infected
male where no spore transfer was possible had a positive effect on offspring immunity
– male offspring of mothers that apparently perceived an infected partner in their
vicinity reacted more sensitively to fungal challenge than male offspring without
paternal pathogen history."
acknowledged_ssus:
- _id: LifeSc
alternative_title:
- ISTA Thesis
article_processing_charge: No
author:
- first_name: Sina
full_name: Metzler, Sina
id: 48204546-F248-11E8-B48F-1D18A9856A87
last_name: Metzler
orcid: 0000-0002-9547-2494
citation:
ama: Metzler S. Pathogen-mediated sexual selection and immunization in ant colonies.
2022. doi:10.15479/AT:ISTA:10727
apa: Metzler, S. (2022). Pathogen-mediated sexual selection and immunization
in ant colonies. Institute of Science and Technology Austria. https://doi.org/10.15479/AT:ISTA:10727
chicago: Metzler, Sina. “Pathogen-Mediated Sexual Selection and Immunization in
Ant Colonies.” Institute of Science and Technology Austria, 2022. https://doi.org/10.15479/AT:ISTA:10727.
ieee: S. Metzler, “Pathogen-mediated sexual selection and immunization in ant colonies,”
Institute of Science and Technology Austria, 2022.
ista: Metzler S. 2022. Pathogen-mediated sexual selection and immunization in ant
colonies. Institute of Science and Technology Austria.
mla: Metzler, Sina. Pathogen-Mediated Sexual Selection and Immunization in Ant
Colonies. Institute of Science and Technology Austria, 2022, doi:10.15479/AT:ISTA:10727.
short: S. Metzler, Pathogen-Mediated Sexual Selection and Immunization in Ant Colonies,
Institute of Science and Technology Austria, 2022.
date_created: 2022-02-04T15:45:12Z
date_published: 2022-02-07T00:00:00Z
date_updated: 2023-09-07T13:43:23Z
day: '07'
ddc:
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degree_awarded: PhD
department:
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ec_funded: 1
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language:
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month: '02'
oa: 1
oa_version: Published Version
project:
- _id: 2649B4DE-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '771402'
name: Epidemics in ant societies on a chip
publication_identifier:
issn:
- 2663-337X
publication_status: published
publisher: Institute of Science and Technology Austria
status: public
supervisor:
- first_name: Sylvia
full_name: Cremer, Sylvia
id: 2F64EC8C-F248-11E8-B48F-1D18A9856A87
last_name: Cremer
orcid: 0000-0002-2193-3868
title: Pathogen-mediated sexual selection and immunization in ant colonies
type: dissertation
user_id: c635000d-4b10-11ee-a964-aac5a93f6ac1
year: '2022'
...
---
_id: '10731'
abstract:
- lang: eng
text: Motivated by COVID-19, we develop and analyze a simple stochastic model for
the spread of disease in human population. We track how the number of infected
and critically ill people develops over time in order to estimate the demand that
is imposed on the hospital system. To keep this demand under control, we consider
a class of simple policies for slowing down and reopening society and we compare
their efficiency in mitigating the spread of the virus from several different
points of view. We find that in order to avoid overwhelming of the hospital system,
a policy must impose a harsh lockdown or it must react swiftly (or both). While
reacting swiftly is universally beneficial, being harsh pays off only when the
country is patient about reopening and when the neighboring countries coordinate
their mitigation efforts. Our work highlights the importance of acting decisively
when closing down and the importance of patience and coordination between neighboring
countries when reopening.
acknowledgement: 'K.C. acknowledges support from ERC Consolidator Grant No. (863818:
ForM-SMart). A.P. acknowledges support from FWF Grant No. J-4220. M.A.N. acknowledges
support from Office of Naval Research grant N00014-16-1-2914 and from the John Templeton
Foundation.'
article_number: '1526'
article_processing_charge: No
article_type: original
arxiv: 1
author:
- first_name: Jakub
full_name: Svoboda, Jakub
id: 130759D2-D7DD-11E9-87D2-DE0DE6697425
last_name: Svoboda
orcid: 0000-0002-1419-3267
- first_name: Josef
full_name: Tkadlec, Josef
last_name: Tkadlec
- first_name: Andreas
full_name: Pavlogiannis, Andreas
id: 49704004-F248-11E8-B48F-1D18A9856A87
last_name: Pavlogiannis
orcid: 0000-0002-8943-0722
- first_name: Krishnendu
full_name: Chatterjee, Krishnendu
id: 2E5DCA20-F248-11E8-B48F-1D18A9856A87
last_name: Chatterjee
orcid: 0000-0002-4561-241X
- first_name: Martin A.
full_name: Nowak, Martin A.
last_name: Nowak
citation:
ama: Svoboda J, Tkadlec J, Pavlogiannis A, Chatterjee K, Nowak MA. Infection dynamics
of COVID-19 virus under lockdown and reopening. Scientific Reports. 2022;12(1).
doi:10.1038/s41598-022-05333-5
apa: Svoboda, J., Tkadlec, J., Pavlogiannis, A., Chatterjee, K., & Nowak, M.
A. (2022). Infection dynamics of COVID-19 virus under lockdown and reopening.
Scientific Reports. Springer Nature. https://doi.org/10.1038/s41598-022-05333-5
chicago: Svoboda, Jakub, Josef Tkadlec, Andreas Pavlogiannis, Krishnendu Chatterjee,
and Martin A. Nowak. “Infection Dynamics of COVID-19 Virus under Lockdown and
Reopening.” Scientific Reports. Springer Nature, 2022. https://doi.org/10.1038/s41598-022-05333-5.
ieee: J. Svoboda, J. Tkadlec, A. Pavlogiannis, K. Chatterjee, and M. A. Nowak, “Infection
dynamics of COVID-19 virus under lockdown and reopening,” Scientific Reports,
vol. 12, no. 1. Springer Nature, 2022.
ista: Svoboda J, Tkadlec J, Pavlogiannis A, Chatterjee K, Nowak MA. 2022. Infection
dynamics of COVID-19 virus under lockdown and reopening. Scientific Reports. 12(1),
1526.
mla: Svoboda, Jakub, et al. “Infection Dynamics of COVID-19 Virus under Lockdown
and Reopening.” Scientific Reports, vol. 12, no. 1, 1526, Springer Nature,
2022, doi:10.1038/s41598-022-05333-5.
short: J. Svoboda, J. Tkadlec, A. Pavlogiannis, K. Chatterjee, M.A. Nowak, Scientific
Reports 12 (2022).
date_created: 2022-02-06T23:01:30Z
date_published: 2022-01-27T00:00:00Z
date_updated: 2025-07-14T09:10:12Z
day: '27'
ddc:
- '570'
department:
- _id: KrCh
doi: 10.1038/s41598-022-05333-5
ec_funded: 1
external_id:
arxiv:
- '2012.15155'
isi:
- '000749198000039'
file:
- access_level: open_access
checksum: 247afd30c173390940f099ead35a28ed
content_type: application/pdf
creator: alisjak
date_created: 2022-02-07T14:57:59Z
date_updated: 2022-02-07T14:57:59Z
file_id: '10744'
file_name: 2022_ScientificReports_Svoboda.pdf
file_size: 2971922
relation: main_file
success: 1
file_date_updated: 2022-02-07T14:57:59Z
has_accepted_license: '1'
intvolume: ' 12'
isi: 1
issue: '1'
language:
- iso: eng
month: '01'
oa: 1
oa_version: Published Version
project:
- _id: 0599E47C-7A3F-11EA-A408-12923DDC885E
call_identifier: H2020
grant_number: '863818'
name: 'Formal Methods for Stochastic Models: Algorithms and Applications'
publication: Scientific Reports
publication_identifier:
eissn:
- 2045-2322
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
scopus_import: '1'
status: public
title: Infection dynamics of COVID-19 virus under lockdown and reopening
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 12
year: '2022'
...
---
_id: '10732'
abstract:
- lang: eng
text: We compute the deterministic approximation of products of Sobolev functions
of large Wigner matrices W and provide an optimal error bound on their fluctuation
with very high probability. This generalizes Voiculescu's seminal theorem from
polynomials to general Sobolev functions, as well as from tracial quantities to
individual matrix elements. Applying the result to eitW for large t, we obtain
a precise decay rate for the overlaps of several deterministic matrices with temporally
well separated Heisenberg time evolutions; thus we demonstrate the thermalisation
effect of the unitary group generated by Wigner matrices.
acknowledgement: We compute the deterministic approximation of products of Sobolev
functions of large Wigner matrices W and provide an optimal error bound on their
fluctuation with very high probability. This generalizes Voiculescu's seminal theorem
from polynomials to general Sobolev functions, as well as from tracial quantities
to individual matrix elements. Applying the result to for large t, we obtain a
precise decay rate for the overlaps of several deterministic matrices with temporally
well separated Heisenberg time evolutions; thus we demonstrate the thermalisation
effect of the unitary group generated by Wigner matrices.
article_number: '109394'
article_processing_charge: Yes (via OA deal)
article_type: original
arxiv: 1
author:
- first_name: Giorgio
full_name: Cipolloni, Giorgio
id: 42198EFA-F248-11E8-B48F-1D18A9856A87
last_name: Cipolloni
orcid: 0000-0002-4901-7992
- first_name: László
full_name: Erdös, László
id: 4DBD5372-F248-11E8-B48F-1D18A9856A87
last_name: Erdös
orcid: 0000-0001-5366-9603
- first_name: Dominik J
full_name: Schröder, Dominik J
id: 408ED176-F248-11E8-B48F-1D18A9856A87
last_name: Schröder
orcid: 0000-0002-2904-1856
citation:
ama: Cipolloni G, Erdös L, Schröder DJ. Thermalisation for Wigner matrices. Journal
of Functional Analysis. 2022;282(8). doi:10.1016/j.jfa.2022.109394
apa: Cipolloni, G., Erdös, L., & Schröder, D. J. (2022). Thermalisation for
Wigner matrices. Journal of Functional Analysis. Elsevier. https://doi.org/10.1016/j.jfa.2022.109394
chicago: Cipolloni, Giorgio, László Erdös, and Dominik J Schröder. “Thermalisation
for Wigner Matrices.” Journal of Functional Analysis. Elsevier, 2022. https://doi.org/10.1016/j.jfa.2022.109394.
ieee: G. Cipolloni, L. Erdös, and D. J. Schröder, “Thermalisation for Wigner matrices,”
Journal of Functional Analysis, vol. 282, no. 8. Elsevier, 2022.
ista: Cipolloni G, Erdös L, Schröder DJ. 2022. Thermalisation for Wigner matrices.
Journal of Functional Analysis. 282(8), 109394.
mla: Cipolloni, Giorgio, et al. “Thermalisation for Wigner Matrices.” Journal
of Functional Analysis, vol. 282, no. 8, 109394, Elsevier, 2022, doi:10.1016/j.jfa.2022.109394.
short: G. Cipolloni, L. Erdös, D.J. Schröder, Journal of Functional Analysis 282
(2022).
date_created: 2022-02-06T23:01:30Z
date_published: 2022-04-15T00:00:00Z
date_updated: 2023-08-02T14:12:35Z
day: '15'
ddc:
- '500'
department:
- _id: LaEr
doi: 10.1016/j.jfa.2022.109394
external_id:
arxiv:
- '2102.09975'
isi:
- '000781239100004'
file:
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checksum: b75fdad606ab507dc61109e0907d86c0
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date_updated: 2022-07-29T07:22:08Z
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file_name: 2022_JourFunctionalAnalysis_Cipolloni.pdf
file_size: 652573
relation: main_file
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file_date_updated: 2022-07-29T07:22:08Z
has_accepted_license: '1'
intvolume: ' 282'
isi: 1
issue: '8'
language:
- iso: eng
month: '04'
oa: 1
oa_version: Published Version
publication: Journal of Functional Analysis
publication_identifier:
eissn:
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issn:
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publication_status: published
publisher: Elsevier
quality_controlled: '1'
scopus_import: '1'
status: public
title: Thermalisation for Wigner matrices
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 282
year: '2022'
...