---
_id: '10764'
abstract:
- lang: eng
text: Presynaptic glutamate replenishment is fundamental to brain function. In high
activity regimes, such as epileptic episodes, this process is thought to rely
on the glutamate-glutamine cycle between neurons and astrocytes. However the presence
of an astroglial glutamine supply, as well as its functional relevance in vivo
in the healthy brain remain controversial, partly due to a lack of tools that
can directly examine glutamine transfer. Here, we generated a fluorescent probe
that tracks glutamine in live cells, which provides direct visual evidence of
an activity-dependent glutamine supply from astroglial networks to presynaptic
structures under physiological conditions. This mobilization is mediated by connexin43,
an astroglial protein with both gap-junction and hemichannel functions, and is
essential for synaptic transmission and object recognition memory. Our findings
uncover an indispensable recruitment of astroglial glutamine in physiological
synaptic activity and memory via an unconventional pathway, thus providing an
astrocyte basis for cognitive processes.
acknowledgement: 'We thank D. Mazaud and. J. Cazères for technical assistance. This
work was supported by grants from the European Research Council (Consolidator grant
#683154) and European Union’s Horizon 2020 research and innovation program (Marie
Sklodowska-Curie Innovative Training Networks, grant #722053, EU-GliaPhD) to N.R.
and from FP7-PEOPLE Marie Curie Intra-European Fellowship for career development
(grant #622289) to G.C.'
article_number: '753'
article_processing_charge: No
article_type: original
author:
- first_name: Giselle T
full_name: Cheung, Giselle T
id: 471195F6-F248-11E8-B48F-1D18A9856A87
last_name: Cheung
- first_name: Danijela
full_name: Bataveljic, Danijela
last_name: Bataveljic
- first_name: Josien
full_name: Visser, Josien
last_name: Visser
- first_name: Naresh
full_name: Kumar, Naresh
last_name: Kumar
- first_name: Julien
full_name: Moulard, Julien
last_name: Moulard
- first_name: Glenn
full_name: Dallérac, Glenn
last_name: Dallérac
- first_name: Daria
full_name: Mozheiko, Daria
last_name: Mozheiko
- first_name: Astrid
full_name: Rollenhagen, Astrid
last_name: Rollenhagen
- first_name: Pascal
full_name: Ezan, Pascal
last_name: Ezan
- first_name: Cédric
full_name: Mongin, Cédric
last_name: Mongin
- first_name: Oana
full_name: Chever, Oana
last_name: Chever
- first_name: Alexis Pierre
full_name: Bemelmans, Alexis Pierre
last_name: Bemelmans
- first_name: Joachim
full_name: Lübke, Joachim
last_name: Lübke
- first_name: Isabelle
full_name: Leray, Isabelle
last_name: Leray
- first_name: Nathalie
full_name: Rouach, Nathalie
last_name: Rouach
citation:
ama: Cheung GT, Bataveljic D, Visser J, et al. Physiological synaptic activity and
recognition memory require astroglial glutamine. Nature Communications.
2022;13. doi:10.1038/s41467-022-28331-7
apa: Cheung, G. T., Bataveljic, D., Visser, J., Kumar, N., Moulard, J., Dallérac,
G., … Rouach, N. (2022). Physiological synaptic activity and recognition memory
require astroglial glutamine. Nature Communications. Springer Nature. https://doi.org/10.1038/s41467-022-28331-7
chicago: Cheung, Giselle T, Danijela Bataveljic, Josien Visser, Naresh Kumar, Julien
Moulard, Glenn Dallérac, Daria Mozheiko, et al. “Physiological Synaptic Activity
and Recognition Memory Require Astroglial Glutamine.” Nature Communications.
Springer Nature, 2022. https://doi.org/10.1038/s41467-022-28331-7.
ieee: G. T. Cheung et al., “Physiological synaptic activity and recognition
memory require astroglial glutamine,” Nature Communications, vol. 13. Springer
Nature, 2022.
ista: Cheung GT, Bataveljic D, Visser J, Kumar N, Moulard J, Dallérac G, Mozheiko
D, Rollenhagen A, Ezan P, Mongin C, Chever O, Bemelmans AP, Lübke J, Leray I,
Rouach N. 2022. Physiological synaptic activity and recognition memory require
astroglial glutamine. Nature Communications. 13, 753.
mla: Cheung, Giselle T., et al. “Physiological Synaptic Activity and Recognition
Memory Require Astroglial Glutamine.” Nature Communications, vol. 13, 753,
Springer Nature, 2022, doi:10.1038/s41467-022-28331-7.
short: G.T. Cheung, D. Bataveljic, J. Visser, N. Kumar, J. Moulard, G. Dallérac,
D. Mozheiko, A. Rollenhagen, P. Ezan, C. Mongin, O. Chever, A.P. Bemelmans, J.
Lübke, I. Leray, N. Rouach, Nature Communications 13 (2022).
date_created: 2022-02-20T23:01:30Z
date_published: 2022-02-08T00:00:00Z
date_updated: 2023-08-02T14:25:01Z
day: '08'
ddc:
- '570'
department:
- _id: SiHi
doi: 10.1038/s41467-022-28331-7
external_id:
isi:
- '000757297200017'
pmid:
- '35136061'
file:
- access_level: open_access
checksum: 51d580aff2327dd957946208a9749e1a
content_type: application/pdf
creator: dernst
date_created: 2022-02-21T07:51:33Z
date_updated: 2022-02-21T07:51:33Z
file_id: '10777'
file_name: 2022_NatureCommunications_Cheung.pdf
file_size: 7910519
relation: main_file
success: 1
file_date_updated: 2022-02-21T07:51:33Z
has_accepted_license: '1'
intvolume: ' 13'
isi: 1
language:
- iso: eng
month: '02'
oa: 1
oa_version: Published Version
pmid: 1
publication: Nature Communications
publication_identifier:
eissn:
- '20411723'
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
scopus_import: '1'
status: public
title: Physiological synaptic activity and recognition memory require astroglial glutamine
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 13
year: '2022'
...
---
_id: '10765'
abstract:
- lang: eng
text: We establish the Hardy-Littlewood property (à la Borovoi-Rudnick) for Zariski
open subsets in affine quadrics of the form q(x1,...,xn)=m, where q is a non-degenerate
integral quadratic form in n>3 variables and m is a non-zero integer. This gives
asymptotic formulas for the density of integral points taking coprime polynomial
values, which is a quantitative version of the arithmetic purity of strong approximation
property off infinity for affine quadrics.
acknowledgement: "We are grateful to Mikhail Borovoi, Zeev Rudnick and Olivier Wienberg
for their interest in our\r\nwork. We would like to address our gratitude to Ulrich
Derenthal for his generous support at Leibniz Universitat Hannover. We are in debt
to Tim Browning for an enlightening discussion and to the anonymous referees for
critical comments, which lead to overall improvements of various preliminary versions
of this paper. Part of this work was carried out and reported during a visit to
the University of Science and Technology of China. We thank Yongqi Liang for offering
warm hospitality. The first author was supported by a Humboldt-Forschungsstipendium.
The second author was supported by grant DE 1646/4-2 of the Deutsche Forschungsgemeinschaft."
article_number: '108236'
article_processing_charge: No
article_type: original
arxiv: 1
author:
- first_name: Yang
full_name: Cao, Yang
last_name: Cao
- first_name: Zhizhong
full_name: Huang, Zhizhong
id: 21f1b52f-2fd1-11eb-a347-a4cdb9b18a51
last_name: Huang
citation:
ama: Cao Y, Huang Z. Arithmetic purity of the Hardy-Littlewood property and geometric
sieve for affine quadrics. Advances in Mathematics. 2022;398(3). doi:10.1016/j.aim.2022.108236
apa: Cao, Y., & Huang, Z. (2022). Arithmetic purity of the Hardy-Littlewood
property and geometric sieve for affine quadrics. Advances in Mathematics.
Elsevier. https://doi.org/10.1016/j.aim.2022.108236
chicago: Cao, Yang, and Zhizhong Huang. “Arithmetic Purity of the Hardy-Littlewood
Property and Geometric Sieve for Affine Quadrics.” Advances in Mathematics.
Elsevier, 2022. https://doi.org/10.1016/j.aim.2022.108236.
ieee: Y. Cao and Z. Huang, “Arithmetic purity of the Hardy-Littlewood property and
geometric sieve for affine quadrics,” Advances in Mathematics, vol. 398,
no. 3. Elsevier, 2022.
ista: Cao Y, Huang Z. 2022. Arithmetic purity of the Hardy-Littlewood property and
geometric sieve for affine quadrics. Advances in Mathematics. 398(3), 108236.
mla: Cao, Yang, and Zhizhong Huang. “Arithmetic Purity of the Hardy-Littlewood Property
and Geometric Sieve for Affine Quadrics.” Advances in Mathematics, vol.
398, no. 3, 108236, Elsevier, 2022, doi:10.1016/j.aim.2022.108236.
short: Y. Cao, Z. Huang, Advances in Mathematics 398 (2022).
date_created: 2022-02-20T23:01:30Z
date_published: 2022-03-26T00:00:00Z
date_updated: 2023-08-02T14:24:18Z
day: '26'
department:
- _id: TiBr
doi: 10.1016/j.aim.2022.108236
external_id:
arxiv:
- '2003.07287'
isi:
- '000792517300014'
intvolume: ' 398'
isi: 1
issue: '3'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://arxiv.org/abs/2003.07287
month: '03'
oa: 1
oa_version: Preprint
publication: Advances in Mathematics
publication_identifier:
eissn:
- 1090-2082
issn:
- 0001-8708
publication_status: published
publisher: Elsevier
quality_controlled: '1'
scopus_import: '1'
status: public
title: Arithmetic purity of the Hardy-Littlewood property and geometric sieve for
affine quadrics
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 398
year: '2022'
...
---
_id: '10766'
abstract:
- lang: eng
text: Tension of the actomyosin cell cortex plays a key role in determining cell–cell
contact growth and size. The level of cortical tension outside of the cell–cell
contact, when pulling at the contact edge, scales with the total size to which
a cell–cell contact can grow [J.-L. Maître et al., Science 338, 253–256 (2012)].
Here, we show in zebrafish primary germ-layer progenitor cells that this monotonic
relationship only applies to a narrow range of cortical tension increase and that
above a critical threshold, contact size inversely scales with cortical tension.
This switch from cortical tension increasing to decreasing progenitor cell–cell
contact size is caused by cortical tension promoting E-cadherin anchoring to the
actomyosin cytoskeleton, thereby increasing clustering and stability of E-cadherin
at the contact. After tension-mediated E-cadherin stabilization at the contact
exceeds a critical threshold level, the rate by which the contact expands in response
to pulling forces from the cortex sharply drops, leading to smaller contacts at
physiologically relevant timescales of contact formation. Thus, the activity of
cortical tension in expanding cell–cell contact size is limited by tension-stabilizing
E-cadherin–actin complexes at the contact.
acknowledged_ssus:
- _id: Bio
- _id: EM-Fac
- _id: PreCl
acknowledgement: 'We thank Guillaume Salbreaux, Silvia Grigolon, Edouard Hannezo,
and Vanessa Barone for discussions and comments on the manuscript and Shayan Shamipour
and Daniel Capek for help with data analysis. We also thank the Imaging & Optics,
Electron Microscopy, and Zebrafish Facility Scientific Service Units at the Institute
of Science and Technology Austria (ISTA)Nasser Darwish-Miranda for continuous support.
We acknowledge Hitoshi Morita for the gift of VinculinB-GFP plasmid. This research
was supported by an ISTA Fellow Marie-Curie Co-funding of regional, national, and
international programmes Grant P_IST_EU01 (to J.S.), European Molecular Biology
Organization Long-Term Fellowship Grant, ALTF reference number: 187-2013 (to M.S.),
Schroedinger Fellowship J4332-B28 (to M.S.), and European Research Council Advanced
Grant (MECSPEC; to C.-P.H.).'
article_number: e2122030119
article_processing_charge: No
article_type: original
author:
- first_name: Jana
full_name: Slovakova, Jana
id: 30F3F2F0-F248-11E8-B48F-1D18A9856A87
last_name: Slovakova
- first_name: Mateusz K
full_name: Sikora, Mateusz K
id: 2F74BCDE-F248-11E8-B48F-1D18A9856A87
last_name: Sikora
- first_name: Feyza N
full_name: Arslan, Feyza N
id: 49DA7910-F248-11E8-B48F-1D18A9856A87
last_name: Arslan
orcid: 0000-0001-5809-9566
- first_name: Silvia
full_name: Caballero Mancebo, Silvia
id: 2F1E1758-F248-11E8-B48F-1D18A9856A87
last_name: Caballero Mancebo
orcid: 0000-0002-5223-3346
- first_name: Gabriel
full_name: Krens, Gabriel
id: 2B819732-F248-11E8-B48F-1D18A9856A87
last_name: Krens
orcid: 0000-0003-4761-5996
- first_name: Walter
full_name: Kaufmann, Walter
id: 3F99E422-F248-11E8-B48F-1D18A9856A87
last_name: Kaufmann
orcid: 0000-0001-9735-5315
- first_name: Jack
full_name: Merrin, Jack
id: 4515C308-F248-11E8-B48F-1D18A9856A87
last_name: Merrin
orcid: 0000-0001-5145-4609
- first_name: Carl-Philipp J
full_name: Heisenberg, Carl-Philipp J
id: 39427864-F248-11E8-B48F-1D18A9856A87
last_name: Heisenberg
orcid: 0000-0002-0912-4566
citation:
ama: Slovakova J, Sikora MK, Arslan FN, et al. Tension-dependent stabilization of
E-cadherin limits cell-cell contact expansion in zebrafish germ-layer progenitor
cells. Proceedings of the National Academy of Sciences of the United States
of America. 2022;119(8). doi:10.1073/pnas.2122030119
apa: Slovakova, J., Sikora, M. K., Arslan, F. N., Caballero Mancebo, S., Krens,
G., Kaufmann, W., … Heisenberg, C.-P. J. (2022). Tension-dependent stabilization
of E-cadherin limits cell-cell contact expansion in zebrafish germ-layer progenitor
cells. Proceedings of the National Academy of Sciences of the United States
of America. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.2122030119
chicago: Slovakova, Jana, Mateusz K Sikora, Feyza N Arslan, Silvia Caballero Mancebo,
Gabriel Krens, Walter Kaufmann, Jack Merrin, and Carl-Philipp J Heisenberg. “Tension-Dependent
Stabilization of E-Cadherin Limits Cell-Cell Contact Expansion in Zebrafish Germ-Layer
Progenitor Cells.” Proceedings of the National Academy of Sciences of the United
States of America. Proceedings of the National Academy of Sciences, 2022.
https://doi.org/10.1073/pnas.2122030119.
ieee: J. Slovakova et al., “Tension-dependent stabilization of E-cadherin
limits cell-cell contact expansion in zebrafish germ-layer progenitor cells,”
Proceedings of the National Academy of Sciences of the United States of America,
vol. 119, no. 8. Proceedings of the National Academy of Sciences, 2022.
ista: Slovakova J, Sikora MK, Arslan FN, Caballero Mancebo S, Krens G, Kaufmann
W, Merrin J, Heisenberg C-PJ. 2022. Tension-dependent stabilization of E-cadherin
limits cell-cell contact expansion in zebrafish germ-layer progenitor cells. Proceedings
of the National Academy of Sciences of the United States of America. 119(8), e2122030119.
mla: Slovakova, Jana, et al. “Tension-Dependent Stabilization of E-Cadherin Limits
Cell-Cell Contact Expansion in Zebrafish Germ-Layer Progenitor Cells.” Proceedings
of the National Academy of Sciences of the United States of America, vol.
119, no. 8, e2122030119, Proceedings of the National Academy of Sciences, 2022,
doi:10.1073/pnas.2122030119.
short: J. Slovakova, M.K. Sikora, F.N. Arslan, S. Caballero Mancebo, G. Krens, W.
Kaufmann, J. Merrin, C.-P.J. Heisenberg, Proceedings of the National Academy of
Sciences of the United States of America 119 (2022).
date_created: 2022-02-20T23:01:31Z
date_published: 2022-02-14T00:00:00Z
date_updated: 2023-08-02T14:26:51Z
day: '14'
ddc:
- '570'
department:
- _id: CaHe
- _id: EM-Fac
- _id: Bio
doi: 10.1073/pnas.2122030119
ec_funded: 1
external_id:
isi:
- '000766926900009'
file:
- access_level: open_access
checksum: d49f83c3580613966f71768ddb9a55a5
content_type: application/pdf
creator: dernst
date_created: 2022-02-21T08:45:11Z
date_updated: 2022-02-21T08:45:11Z
file_id: '10780'
file_name: 2022_PNAS_Slovakova.pdf
file_size: 1609678
relation: main_file
success: 1
file_date_updated: 2022-02-21T08:45:11Z
has_accepted_license: '1'
intvolume: ' 119'
isi: 1
issue: '8'
language:
- iso: eng
month: '02'
oa: 1
oa_version: Published Version
project:
- _id: 25681D80-B435-11E9-9278-68D0E5697425
call_identifier: FP7
grant_number: '291734'
name: International IST Postdoc Fellowship Programme
- _id: 260F1432-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '742573'
name: Interaction and feedback between cell mechanics and fate specification in
vertebrate gastrulation
- _id: 2521E28E-B435-11E9-9278-68D0E5697425
grant_number: 187-2013
name: Modulation of adhesion function in cell-cell contact formation by cortical
tension
publication: Proceedings of the National Academy of Sciences of the United States
of America
publication_identifier:
eissn:
- '10916490'
publication_status: published
publisher: Proceedings of the National Academy of Sciences
quality_controlled: '1'
related_material:
record:
- id: '9750'
relation: earlier_version
status: public
scopus_import: '1'
status: public
title: Tension-dependent stabilization of E-cadherin limits cell-cell contact expansion
in zebrafish germ-layer progenitor cells
tmp:
image: /images/cc_by_nc_nd.png
legal_code_url: https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode
name: Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
(CC BY-NC-ND 4.0)
short: CC BY-NC-ND (4.0)
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 119
year: '2022'
...
---
_id: '10767'
abstract:
- lang: eng
text: The t-haplotype of mice is a classical model for autosomal transmission distortion.
A largely non-recombining variant of the proximal region of chromosome 17, it
is transmitted to more than 90% of the progeny of heterozygous males through the
disabling of sperm carrying a standard chromosome. While extensive genetic and
functional work has shed light on individual genes involved in drive, much less
is known about the evolution and function of the rest of its hundreds of genes.
Here, we characterize the sequence and expression of dozens of t-specific transcripts
and of their chromosome 17 homologues. Many genes showed reduced expression of
the t-allele, but an equal number of genes showed increased expression of their
t-copy, consistent with increased activity or a newly evolved function. Genes
on the t-haplotype had a significantly higher non-synonymous substitution rate
than their homologues on the standard chromosome, with several genes harbouring
dN/dS ratios above 1. Finally, the t-haplotype has acquired at least two genes
from other chromosomes, which show high and tissue-specific expression. These
results provide a first overview of the gene content of this selfish element,
and support a more dynamic evolutionary scenario than expected of a large genomic
region with almost no recombination.
acknowledgement: "This project has received funding from the European Research Council
under the European Union’s Horizon 2020 research and innovation program (grant agreement
no. 715257) and from the Swiss National Science Foundation (grant no. 310030_189145).\r\nWe
thank Jari Garbely of the Department of Evolutionary Biology and Environmental Studies,
University of Zurich, Zurich, Switzerland, for conducting the PCR verification.
Barbara\r\nKonig, Gabi Stichel and A.K.L. collected mouse tissue samples, from the
field study led by R.K.K. "
article_processing_charge: No
article_type: original
author:
- first_name: Réka K
full_name: Kelemen, Réka K
id: 48D3F8DE-F248-11E8-B48F-1D18A9856A87
last_name: Kelemen
- first_name: Marwan N
full_name: Elkrewi, Marwan N
id: 0B46FACA-A8E1-11E9-9BD3-79D1E5697425
last_name: Elkrewi
orcid: 0000-0002-5328-7231
- first_name: Anna K.
full_name: Lindholm, Anna K.
last_name: Lindholm
- first_name: Beatriz
full_name: Vicoso, Beatriz
id: 49E1C5C6-F248-11E8-B48F-1D18A9856A87
last_name: Vicoso
orcid: 0000-0002-4579-8306
citation:
ama: 'Kelemen RK, Elkrewi MN, Lindholm AK, Vicoso B. Novel patterns of expression
and recruitment of new genes on the t-haplotype, a mouse selfish chromosome. Proceedings
of the Royal Society B: Biological Sciences. 2022;289(1968):20211985. doi:10.1098/rspb.2021.1985'
apa: 'Kelemen, R. K., Elkrewi, M. N., Lindholm, A. K., & Vicoso, B. (2022).
Novel patterns of expression and recruitment of new genes on the t-haplotype,
a mouse selfish chromosome. Proceedings of the Royal Society B: Biological
Sciences. The Royal Society. https://doi.org/10.1098/rspb.2021.1985'
chicago: 'Kelemen, Réka K, Marwan N Elkrewi, Anna K. Lindholm, and Beatriz Vicoso.
“Novel Patterns of Expression and Recruitment of New Genes on the T-Haplotype,
a Mouse Selfish Chromosome.” Proceedings of the Royal Society B: Biological
Sciences. The Royal Society, 2022. https://doi.org/10.1098/rspb.2021.1985.'
ieee: 'R. K. Kelemen, M. N. Elkrewi, A. K. Lindholm, and B. Vicoso, “Novel patterns
of expression and recruitment of new genes on the t-haplotype, a mouse selfish
chromosome,” Proceedings of the Royal Society B: Biological Sciences, vol.
289, no. 1968. The Royal Society, p. 20211985, 2022.'
ista: 'Kelemen RK, Elkrewi MN, Lindholm AK, Vicoso B. 2022. Novel patterns of expression
and recruitment of new genes on the t-haplotype, a mouse selfish chromosome. Proceedings
of the Royal Society B: Biological Sciences. 289(1968), 20211985.'
mla: 'Kelemen, Réka K., et al. “Novel Patterns of Expression and Recruitment of
New Genes on the T-Haplotype, a Mouse Selfish Chromosome.” Proceedings of the
Royal Society B: Biological Sciences, vol. 289, no. 1968, The Royal Society,
2022, p. 20211985, doi:10.1098/rspb.2021.1985.'
short: 'R.K. Kelemen, M.N. Elkrewi, A.K. Lindholm, B. Vicoso, Proceedings of the
Royal Society B: Biological Sciences 289 (2022) 20211985.'
date_created: 2022-02-20T23:01:31Z
date_published: 2022-02-09T00:00:00Z
date_updated: 2023-08-02T14:26:07Z
day: '09'
ddc:
- '570'
department:
- _id: BeVi
doi: 10.1098/rspb.2021.1985
ec_funded: 1
external_id:
isi:
- '000752812800012'
pmid:
- '35135349'
file:
- access_level: open_access
checksum: 27042a3706ae52a919fed1ac114bf7bb
content_type: application/pdf
creator: dernst
date_created: 2022-02-21T08:17:38Z
date_updated: 2022-02-21T08:17:38Z
file_id: '10779'
file_name: 2022_ProceedingsRoyalSocB_Kelemen.pdf
file_size: 2366976
relation: main_file
success: 1
file_date_updated: 2022-02-21T08:17:38Z
has_accepted_license: '1'
intvolume: ' 289'
isi: 1
issue: '1968'
language:
- iso: eng
month: '02'
oa: 1
oa_version: Published Version
page: '20211985'
pmid: 1
project:
- _id: 250BDE62-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '715257'
name: Prevalence and Influence of Sexual Antagonism on Genome Evolution
publication: 'Proceedings of the Royal Society B: Biological Sciences'
publication_identifier:
eissn:
- '14712954'
publication_status: published
publisher: The Royal Society
quality_controlled: '1'
scopus_import: '1'
status: public
title: Novel patterns of expression and recruitment of new genes on the t-haplotype,
a mouse selfish chromosome
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 289
year: '2022'
...
---
_id: '10768'
abstract:
- lang: eng
text: Among the most fascinated properties of the plant hormone auxin is its ability
to promote formation of its own directional transport routes. These gradually
narrowing auxin channels form from the auxin source toward the sink and involve
coordinated, collective polarization of individual cells. Once established, the
channels provide positional information, along which new vascular strands form,
for example, during organogenesis, regeneration, or leave venation. The main prerequisite
of this still mysterious auxin canalization mechanism is a feedback between auxin
signaling and its directional transport. This is manifested by auxin-induced re-arrangements
of polar, subcellular localization of PIN-FORMED (PIN) auxin exporters. Immanent
open questions relate to how position of auxin source and sink as well as tissue
context are sensed and translated into tissue polarization and how cells communicate
to polarize coordinately. Recently, identification of the first molecular players
opens new avenues into molecular studies of this intriguing example of self-organizing
plant development.
acknowledgement: The authors apologize to those researchers whose work was not cited.
In addition, exciting topics such as PIN polarization in context of phyllotaxis,
shoot branching and termination of gravitropic bending, or role of additional auxin
transporters could not have been included owing to lack of space. This work was
supported by the Czech Science Foundation GAČR (GA18-26981S). The authors also acknowledge
the EMBO for supporting J.H. with a long-term fellowship (ALTF217-2021).
article_number: '102174'
article_processing_charge: Yes (via OA deal)
article_type: original
author:
- first_name: Jakub
full_name: Hajny, Jakub
id: 4800CC20-F248-11E8-B48F-1D18A9856A87
last_name: Hajny
orcid: 0000-0003-2140-7195
- first_name: Shutang
full_name: Tan, Shutang
id: 2DE75584-F248-11E8-B48F-1D18A9856A87
last_name: Tan
orcid: 0000-0002-0471-8285
- first_name: Jiří
full_name: Friml, Jiří
id: 4159519E-F248-11E8-B48F-1D18A9856A87
last_name: Friml
orcid: 0000-0002-8302-7596
citation:
ama: 'Hajny J, Tan S, Friml J. Auxin canalization: From speculative models toward
molecular players. Current Opinion in Plant Biology. 2022;65(2). doi:10.1016/j.pbi.2022.102174'
apa: 'Hajny, J., Tan, S., & Friml, J. (2022). Auxin canalization: From speculative
models toward molecular players. Current Opinion in Plant Biology. Elsevier.
https://doi.org/10.1016/j.pbi.2022.102174'
chicago: 'Hajny, Jakub, Shutang Tan, and Jiří Friml. “Auxin Canalization: From Speculative
Models toward Molecular Players.” Current Opinion in Plant Biology. Elsevier,
2022. https://doi.org/10.1016/j.pbi.2022.102174.'
ieee: 'J. Hajny, S. Tan, and J. Friml, “Auxin canalization: From speculative models
toward molecular players,” Current Opinion in Plant Biology, vol. 65, no.
2. Elsevier, 2022.'
ista: 'Hajny J, Tan S, Friml J. 2022. Auxin canalization: From speculative models
toward molecular players. Current Opinion in Plant Biology. 65(2), 102174.'
mla: 'Hajny, Jakub, et al. “Auxin Canalization: From Speculative Models toward Molecular
Players.” Current Opinion in Plant Biology, vol. 65, no. 2, 102174, Elsevier,
2022, doi:10.1016/j.pbi.2022.102174.'
short: J. Hajny, S. Tan, J. Friml, Current Opinion in Plant Biology 65 (2022).
date_created: 2022-02-20T23:01:32Z
date_published: 2022-02-01T00:00:00Z
date_updated: 2023-08-02T14:29:12Z
day: '01'
ddc:
- '580'
department:
- _id: JiFr
doi: 10.1016/j.pbi.2022.102174
external_id:
isi:
- '000758724700004'
pmid:
- '35123880'
file:
- access_level: open_access
checksum: f1ee02b6fb4200934eeb31fa69120885
content_type: application/pdf
creator: dernst
date_created: 2022-03-10T13:34:09Z
date_updated: 2022-03-10T13:34:09Z
file_id: '10844'
file_name: 2022_CurrentOpPlantBiology_Hajny.pdf
file_size: 820322
relation: main_file
success: 1
file_date_updated: 2022-03-10T13:34:09Z
has_accepted_license: '1'
intvolume: ' 65'
isi: 1
issue: '2'
language:
- iso: eng
month: '02'
oa: 1
oa_version: Published Version
pmid: 1
publication: Current Opinion in Plant Biology
publication_identifier:
issn:
- 1369-5266
publication_status: published
publisher: Elsevier
quality_controlled: '1'
scopus_import: '1'
status: public
title: 'Auxin canalization: From speculative models toward molecular players'
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 65
year: '2022'
...
---
_id: '10769'
abstract:
- lang: eng
text: studiamos aspectos de Teoría Cuántica de Campos a densidad finita usando técnicas
y conceptos de información cuántica. Nos enfocamos en fermiones de Dirac masivos
con potencial químico en 1+1 dimensiones espacio-temporales. Usando la entropía
de entrelazamiento en un intervalo, construimos la función c entrópica que es
finita. Esta función c no es monótona, e incorpora el entrelazamiento de largo
alcance proveniente de la superficie de Fermi. Motivados por trabajos previos
de modelos en la red, calculamos numéricamente las entropías de Renyi y encontramos
oscilaciones de Friedel. Seguidamente, analizamos la información mutua como una
medida de correlación entre diferentes regiones. Usando una expansión de distancia
grande desarrollada por Cardy, argumentamos que la información mutua detecta las
correlaciones inducidas por la superficie de Fermi todavía al orden dominante
en la expansión. Finalmente, analizamos la entropía relativa y sus generalizaciones
de Renyi para distinguir estados con diferente carga. Encontramos que estados
en diferentes sectores de superselección dan origen a un comportamiento super-extensivo
en la entropía relativa.
acknowledgement: "Se agradece a Horacio Casini por distintas discusiones y comentarios
a lo largo del trabajo. LD cuenta con el apoyo de CNEA y UNCuyo, Inst. GT cuenta
con el apoyo de CONICET,\r\nANPCyT, CNEA, y UNCuyo, Inst. Balseiro. RM cuenta con
el apoyo de IST Austria. MS cuenta con el apoyode CONICET y UNCuyo, Inst. Balseiro.
También se agradece a la Asociación Argentina de Física por la posibilidad de presentar
este artículo en el marco de una Mención Especial por el Premio Luis Másperi 2020."
article_processing_charge: No
article_type: original
author:
- first_name: L.
full_name: Daguerre, L.
last_name: Daguerre
- first_name: G.
full_name: Torroba, G.
last_name: Torroba
- first_name: Raimel A
full_name: Medina Ramos, Raimel A
id: CE680B90-D85A-11E9-B684-C920E6697425
last_name: Medina Ramos
- first_name: M.
full_name: Solís, M.
last_name: Solís
citation:
ama: 'Daguerre L, Torroba G, Medina Ramos RA, Solís M. Non relativistic quantum
field theory: Dynamics and irreversibility. Anales de la Asociacion Fisica
Argentina. 2022;32(4):93-98. doi:10.31527/analesafa.2021.32.4.93'
apa: 'Daguerre, L., Torroba, G., Medina Ramos, R. A., & Solís, M. (2022). Non
relativistic quantum field theory: Dynamics and irreversibility. Anales de
la Asociacion Fisica Argentina. Asociación Física Argentina. https://doi.org/10.31527/analesafa.2021.32.4.93'
chicago: 'Daguerre, L., G. Torroba, Raimel A Medina Ramos, and M. Solís. “Non relativistic
quantum field theory: Dynamics and irreversibility.” Anales de la Asociacion
Fisica Argentina. Asociación Física Argentina, 2022. https://doi.org/10.31527/analesafa.2021.32.4.93.'
ieee: 'L. Daguerre, G. Torroba, R. A. Medina Ramos, and M. Solís, “Non relativistic
quantum field theory: Dynamics and irreversibility,” Anales de la Asociacion
Fisica Argentina, vol. 32, no. 4. Asociación Física Argentina, pp. 93–98,
2022.'
ista: 'Daguerre L, Torroba G, Medina Ramos RA, Solís M. 2022. Non relativistic quantum
field theory: Dynamics and irreversibility. Anales de la Asociacion Fisica Argentina.
32(4), 93–98.'
mla: 'Daguerre, L., et al. “Non relativistic quantum field theory: Dynamics and
irreversibility.” Anales de la Asociacion Fisica Argentina, vol. 32, no.
4, Asociación Física Argentina, 2022, pp. 93–98, doi:10.31527/analesafa.2021.32.4.93.'
short: L. Daguerre, G. Torroba, R.A. Medina Ramos, M. Solís, Anales de la Asociacion
Fisica Argentina 32 (2022) 93–98.
date_created: 2022-02-20T23:01:32Z
date_published: 2022-01-13T00:00:00Z
date_updated: 2022-02-21T09:36:01Z
day: '13'
ddc:
- '530'
department:
- _id: MaSe
doi: 10.31527/analesafa.2021.32.4.93
file:
- access_level: open_access
checksum: ca66a3017205677c5b4d22b3bb74fb0b
content_type: application/pdf
creator: dernst
date_created: 2022-02-21T09:32:44Z
date_updated: 2022-02-21T09:32:44Z
file_id: '10782'
file_name: 2022_AnalesAFA_Daguerre.pdf
file_size: 4505751
relation: main_file
success: 1
file_date_updated: 2022-02-21T09:32:44Z
has_accepted_license: '1'
intvolume: ' 32'
issue: '4'
language:
- iso: spa
month: '01'
oa: 1
oa_version: Published Version
page: 93-98
publication: Anales de la Asociacion Fisica Argentina
publication_identifier:
eissn:
- '18501168'
publication_status: published
publisher: Asociación Física Argentina
quality_controlled: '1'
scopus_import: '1'
status: public
title: 'Non relativistic quantum field theory: Dynamics and irreversibility'
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 32
year: '2022'
...
---
_id: '10771'
abstract:
- lang: eng
text: A critical overview of the theory of the chirality-induced spin selectivity
(CISS) effect, that is, phenomena in which the chirality of molecular species
imparts significant spin selectivity to various electron processes, is provided.
Based on discussions in a recently held workshop, and further work published since,
the status of CISS effects—in electron transmission, electron transport, and chemical
reactions—is reviewed. For each, a detailed discussion of the state-of-the-art
in theoretical understanding is provided and remaining challenges and research
opportunities are identified.
article_number: '2106629'
article_processing_charge: No
article_type: review
arxiv: 1
author:
- first_name: Ferdinand
full_name: Evers, Ferdinand
last_name: Evers
- first_name: Amnon
full_name: Aharony, Amnon
last_name: Aharony
- first_name: Nir
full_name: Bar-Gill, Nir
last_name: Bar-Gill
- first_name: Ora
full_name: Entin-Wohlman, Ora
last_name: Entin-Wohlman
- first_name: Per
full_name: Hedegård, Per
last_name: Hedegård
- first_name: Oded
full_name: Hod, Oded
last_name: Hod
- first_name: Pavel
full_name: Jelinek, Pavel
last_name: Jelinek
- first_name: Grzegorz
full_name: Kamieniarz, Grzegorz
last_name: Kamieniarz
- first_name: Mikhail
full_name: Lemeshko, Mikhail
id: 37CB05FA-F248-11E8-B48F-1D18A9856A87
last_name: Lemeshko
orcid: 0000-0002-6990-7802
- first_name: Karen
full_name: Michaeli, Karen
last_name: Michaeli
- first_name: Vladimiro
full_name: Mujica, Vladimiro
last_name: Mujica
- first_name: Ron
full_name: Naaman, Ron
last_name: Naaman
- first_name: Yossi
full_name: Paltiel, Yossi
last_name: Paltiel
- first_name: Sivan
full_name: Refaely-Abramson, Sivan
last_name: Refaely-Abramson
- first_name: Oren
full_name: Tal, Oren
last_name: Tal
- first_name: Jos
full_name: Thijssen, Jos
last_name: Thijssen
- first_name: Michael
full_name: Thoss, Michael
last_name: Thoss
- first_name: Jan M.
full_name: Van Ruitenbeek, Jan M.
last_name: Van Ruitenbeek
- first_name: Latha
full_name: Venkataraman, Latha
last_name: Venkataraman
- first_name: David H.
full_name: Waldeck, David H.
last_name: Waldeck
- first_name: Binghai
full_name: Yan, Binghai
last_name: Yan
- first_name: Leeor
full_name: Kronik, Leeor
last_name: Kronik
citation:
ama: 'Evers F, Aharony A, Bar-Gill N, et al. Theory of chirality induced spin selectivity:
Progress and challenges. Advanced Materials. 2022;34(13). doi:10.1002/adma.202106629'
apa: 'Evers, F., Aharony, A., Bar-Gill, N., Entin-Wohlman, O., Hedegård, P., Hod,
O., … Kronik, L. (2022). Theory of chirality induced spin selectivity: Progress
and challenges. Advanced Materials. Wiley. https://doi.org/10.1002/adma.202106629'
chicago: 'Evers, Ferdinand, Amnon Aharony, Nir Bar-Gill, Ora Entin-Wohlman, Per
Hedegård, Oded Hod, Pavel Jelinek, et al. “Theory of Chirality Induced Spin Selectivity:
Progress and Challenges.” Advanced Materials. Wiley, 2022. https://doi.org/10.1002/adma.202106629.'
ieee: 'F. Evers et al., “Theory of chirality induced spin selectivity: Progress
and challenges,” Advanced Materials, vol. 34, no. 13. Wiley, 2022.'
ista: 'Evers F, Aharony A, Bar-Gill N, Entin-Wohlman O, Hedegård P, Hod O, Jelinek
P, Kamieniarz G, Lemeshko M, Michaeli K, Mujica V, Naaman R, Paltiel Y, Refaely-Abramson
S, Tal O, Thijssen J, Thoss M, Van Ruitenbeek JM, Venkataraman L, Waldeck DH,
Yan B, Kronik L. 2022. Theory of chirality induced spin selectivity: Progress
and challenges. Advanced Materials. 34(13), 2106629.'
mla: 'Evers, Ferdinand, et al. “Theory of Chirality Induced Spin Selectivity: Progress
and Challenges.” Advanced Materials, vol. 34, no. 13, 2106629, Wiley, 2022,
doi:10.1002/adma.202106629.'
short: F. Evers, A. Aharony, N. Bar-Gill, O. Entin-Wohlman, P. Hedegård, O. Hod,
P. Jelinek, G. Kamieniarz, M. Lemeshko, K. Michaeli, V. Mujica, R. Naaman, Y.
Paltiel, S. Refaely-Abramson, O. Tal, J. Thijssen, M. Thoss, J.M. Van Ruitenbeek,
L. Venkataraman, D.H. Waldeck, B. Yan, L. Kronik, Advanced Materials 34 (2022).
date_created: 2022-02-20T23:01:33Z
date_published: 2022-04-01T00:00:00Z
date_updated: 2023-08-02T14:30:22Z
day: '01'
department:
- _id: MiLe
doi: 10.1002/adma.202106629
external_id:
arxiv:
- '2108.09998'
isi:
- '000753795900001'
intvolume: ' 34'
isi: 1
issue: '13'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://arxiv.org/abs/2108.09998
month: '04'
oa: 1
oa_version: Preprint
publication: Advanced Materials
publication_identifier:
eissn:
- '15214095'
issn:
- '09359648'
publication_status: published
publisher: Wiley
quality_controlled: '1'
scopus_import: '1'
status: public
title: 'Theory of chirality induced spin selectivity: Progress and challenges'
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 34
year: '2022'
...
---
_id: '10772'
abstract:
- lang: eng
text: We introduce tropical corals, balanced trees in a half-space, and show that
they correspond to holomorphic polygons capturing the product rule in Lagrangian
Floer theory for the elliptic curve. We then prove a correspondence theorem equating
counts of tropical corals to punctured log Gromov–Witten invariants of the Tate
curve. This implies that the homogeneous coordinate ring of the mirror to the
Tate curve is isomorphic to the degree-zero part of symplectic cohomology, confirming
a prediction of homological mirror symmetry.
acknowledgement: 'This paper is based on my PhD thesis, which would not be possible
without the support of my advisor Bernd Siebert. I also thank Dan Abramovich, Mohammed
Abouzaid, Mark Gross, Tom Coates and Dimitri Zvonkine for many useful conversations.
Finally, I thank the anonymous referees for their many insightful comments and valuable
suggestions which have resulted in major improvements to this article. This project
has received funding from the EuropeanResearch Council (ERC) under the European
Union’s Horizon 2020 research and innovation programme (Grant Agreement Number:
682603), and from Fondation Mathématique Jacques Hadamard. '
article_processing_charge: Yes (via OA deal)
article_type: original
arxiv: 1
author:
- first_name: Nuroemuer Huelya
full_name: Arguez, Nuroemuer Huelya
id: 3c26b22e-c843-11eb-aa56-d38ffa0bdd08
last_name: Arguez
citation:
ama: Arguez NH. Mirror symmetry for the Tate curve via tropical and log corals.
Journal of the London Mathematical Society. 2022;105(1):343-411. doi:10.1112/jlms.12515
apa: Arguez, N. H. (2022). Mirror symmetry for the Tate curve via tropical and log
corals. Journal of the London Mathematical Society. London Mathematical
Society. https://doi.org/10.1112/jlms.12515
chicago: Arguez, Nuroemuer Huelya. “Mirror Symmetry for the Tate Curve via Tropical
and Log Corals.” Journal of the London Mathematical Society. London Mathematical
Society, 2022. https://doi.org/10.1112/jlms.12515.
ieee: N. H. Arguez, “Mirror symmetry for the Tate curve via tropical and log corals,”
Journal of the London Mathematical Society, vol. 105, no. 1. London Mathematical
Society, pp. 343–411, 2022.
ista: Arguez NH. 2022. Mirror symmetry for the Tate curve via tropical and log corals.
Journal of the London Mathematical Society. 105(1), 343–411.
mla: Arguez, Nuroemuer Huelya. “Mirror Symmetry for the Tate Curve via Tropical
and Log Corals.” Journal of the London Mathematical Society, vol. 105,
no. 1, London Mathematical Society, 2022, pp. 343–411, doi:10.1112/jlms.12515.
short: N.H. Arguez, Journal of the London Mathematical Society 105 (2022) 343–411.
date_created: 2022-02-20T23:01:33Z
date_published: 2022-02-05T00:00:00Z
date_updated: 2023-08-02T14:29:50Z
day: '05'
ddc:
- '510'
department:
- _id: TaHa
doi: 10.1112/jlms.12515
external_id:
arxiv:
- '1712.10260'
isi:
- '000751600600001'
file:
- access_level: open_access
checksum: 8bd0fd9694be894a191857ddf27678f0
content_type: application/pdf
creator: dernst
date_created: 2022-02-21T11:22:58Z
date_updated: 2022-02-21T11:22:58Z
file_id: '10783'
file_name: 2022_JournLondonMathSociety_Arguez.pdf
file_size: 936873
relation: main_file
success: 1
file_date_updated: 2022-02-21T11:22:58Z
has_accepted_license: '1'
intvolume: ' 105'
isi: 1
issue: '1'
language:
- iso: eng
month: '02'
oa: 1
oa_version: Published Version
page: 343-411
publication: Journal of the London Mathematical Society
publication_identifier:
eissn:
- 1469-7750
issn:
- 0024-6107
publication_status: published
publisher: London Mathematical Society
quality_controlled: '1'
scopus_import: '1'
status: public
title: Mirror symmetry for the Tate curve via tropical and log corals
tmp:
image: /images/cc_by_nc_nd.png
legal_code_url: https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode
name: Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
(CC BY-NC-ND 4.0)
short: CC BY-NC-ND (4.0)
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 105
year: '2022'
...
---
_id: '10773'
abstract:
- lang: eng
text: The Voronoi tessellation in Rd is defined by locally minimizing the power
distance to given weighted points. Symmetrically, the Delaunay mosaic can be defined
by locally maximizing the negative power distance to other such points. We prove
that the average of the two piecewise quadratic functions is piecewise linear,
and that all three functions have the same critical points and values. Discretizing
the two piecewise quadratic functions, we get the alpha shapes as sublevel sets
of the discrete function on the Delaunay mosaic, and analogous shapes as superlevel
sets of the discrete function on the Voronoi tessellation. For the same non-critical
value, the corresponding shapes are disjoint, separated by a narrow channel that
contains no critical points but the entire level set of the piecewise linear function.
acknowledgement: Open access funding provided by the Institute of Science and Technology
(IST Austria).
article_processing_charge: Yes (via OA deal)
article_type: original
author:
- first_name: Ranita
full_name: Biswas, Ranita
id: 3C2B033E-F248-11E8-B48F-1D18A9856A87
last_name: Biswas
orcid: 0000-0002-5372-7890
- first_name: Sebastiano
full_name: Cultrera Di Montesano, Sebastiano
id: 34D2A09C-F248-11E8-B48F-1D18A9856A87
last_name: Cultrera Di Montesano
orcid: 0000-0001-6249-0832
- first_name: Herbert
full_name: Edelsbrunner, Herbert
id: 3FB178DA-F248-11E8-B48F-1D18A9856A87
last_name: Edelsbrunner
orcid: 0000-0002-9823-6833
- first_name: Morteza
full_name: Saghafian, Morteza
last_name: Saghafian
citation:
ama: Biswas R, Cultrera di Montesano S, Edelsbrunner H, Saghafian M. Continuous
and discrete radius functions on Voronoi tessellations and Delaunay mosaics. Discrete
and Computational Geometry. 2022;67:811-842. doi:10.1007/s00454-022-00371-2
apa: Biswas, R., Cultrera di Montesano, S., Edelsbrunner, H., & Saghafian, M.
(2022). Continuous and discrete radius functions on Voronoi tessellations and
Delaunay mosaics. Discrete and Computational Geometry. Springer Nature.
https://doi.org/10.1007/s00454-022-00371-2
chicago: Biswas, Ranita, Sebastiano Cultrera di Montesano, Herbert Edelsbrunner,
and Morteza Saghafian. “Continuous and Discrete Radius Functions on Voronoi Tessellations
and Delaunay Mosaics.” Discrete and Computational Geometry. Springer Nature,
2022. https://doi.org/10.1007/s00454-022-00371-2.
ieee: R. Biswas, S. Cultrera di Montesano, H. Edelsbrunner, and M. Saghafian, “Continuous
and discrete radius functions on Voronoi tessellations and Delaunay mosaics,”
Discrete and Computational Geometry, vol. 67. Springer Nature, pp. 811–842,
2022.
ista: Biswas R, Cultrera di Montesano S, Edelsbrunner H, Saghafian M. 2022. Continuous
and discrete radius functions on Voronoi tessellations and Delaunay mosaics. Discrete
and Computational Geometry. 67, 811–842.
mla: Biswas, Ranita, et al. “Continuous and Discrete Radius Functions on Voronoi
Tessellations and Delaunay Mosaics.” Discrete and Computational Geometry,
vol. 67, Springer Nature, 2022, pp. 811–42, doi:10.1007/s00454-022-00371-2.
short: R. Biswas, S. Cultrera di Montesano, H. Edelsbrunner, M. Saghafian, Discrete
and Computational Geometry 67 (2022) 811–842.
date_created: 2022-02-20T23:01:34Z
date_published: 2022-04-01T00:00:00Z
date_updated: 2023-08-02T14:31:25Z
day: '01'
ddc:
- '510'
department:
- _id: HeEd
doi: 10.1007/s00454-022-00371-2
external_id:
isi:
- '000752175300002'
file:
- access_level: open_access
checksum: 9383d3b70561bacee905e335dc922680
content_type: application/pdf
creator: dernst
date_created: 2022-08-02T06:07:55Z
date_updated: 2022-08-02T06:07:55Z
file_id: '11718'
file_name: 2022_DiscreteCompGeometry_Biswas.pdf
file_size: 2518111
relation: main_file
success: 1
file_date_updated: 2022-08-02T06:07:55Z
has_accepted_license: '1'
intvolume: ' 67'
isi: 1
language:
- iso: eng
month: '04'
oa: 1
oa_version: Published Version
page: 811-842
publication: Discrete and Computational Geometry
publication_identifier:
eissn:
- 1432-0444
issn:
- 0179-5376
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
scopus_import: '1'
status: public
title: Continuous and discrete radius functions on Voronoi tessellations and Delaunay
mosaics
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 67
year: '2022'
...
---
_id: '10774'
abstract:
- lang: eng
text: We study the problem of specifying sequential information-flow properties
of systems. Information-flow properties are hyperproperties, as they compare different
traces of a system. Sequential information-flow properties can express changes,
over time, in the information-flow constraints. For example, information-flow
constraints during an initialization phase of a system may be different from information-flow
constraints that are required during the operation phase. We formalize several
variants of interpreting sequential information-flow constraints, which arise
from different assumptions about what can be observed of the system. For this
purpose, we introduce a first-order logic, called Hypertrace Logic, with both
trace and time quantifiers for specifying linear-time hyperproperties. We prove
that HyperLTL, which corresponds to a fragment of Hypertrace Logic with restricted
quantifier prefixes, cannot specify the majority of the studied variants of sequential
information flow, including all variants in which the transition between sequential
phases (such as initialization and operation) happens asynchronously. Our results
rely on new equivalences between sets of traces that cannot be distinguished by
certain classes of formulas from Hypertrace Logic. This presents a new approach
to proving inexpressiveness results for HyperLTL.
acknowledgement: This work was funded in part by the Wittgenstein Award Z211-N23 of
the Austrian Science Fund (FWF) and by the FWF project W1255-N23.
alternative_title:
- LNCS
article_processing_charge: No
arxiv: 1
author:
- first_name: Ezio
full_name: Bartocci, Ezio
last_name: Bartocci
- first_name: Thomas
full_name: Ferrere, Thomas
id: 40960E6E-F248-11E8-B48F-1D18A9856A87
last_name: Ferrere
orcid: 0000-0001-5199-3143
- first_name: Thomas A
full_name: Henzinger, Thomas A
id: 40876CD8-F248-11E8-B48F-1D18A9856A87
last_name: Henzinger
orcid: 0000-0002-2985-7724
- first_name: Dejan
full_name: Nickovic, Dejan
id: 41BCEE5C-F248-11E8-B48F-1D18A9856A87
last_name: Nickovic
- first_name: Ana Oliveira
full_name: Da Costa, Ana Oliveira
last_name: Da Costa
citation:
ama: 'Bartocci E, Ferrere T, Henzinger TA, Nickovic D, Da Costa AO. Flavors of sequential
information flow. In: Lecture Notes in Computer Science (Including Subseries
Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics).
Vol 13182. Springer Nature; 2022:1-19. doi:10.1007/978-3-030-94583-1_1'
apa: 'Bartocci, E., Ferrere, T., Henzinger, T. A., Nickovic, D., & Da Costa,
A. O. (2022). Flavors of sequential information flow. In Lecture Notes in Computer
Science (including subseries Lecture Notes in Artificial Intelligence and Lecture
Notes in Bioinformatics) (Vol. 13182, pp. 1–19). Philadelphia, PA, United
States: Springer Nature. https://doi.org/10.1007/978-3-030-94583-1_1'
chicago: Bartocci, Ezio, Thomas Ferrere, Thomas A Henzinger, Dejan Nickovic, and
Ana Oliveira Da Costa. “Flavors of Sequential Information Flow.” In Lecture
Notes in Computer Science (Including Subseries Lecture Notes in Artificial Intelligence
and Lecture Notes in Bioinformatics), 13182:1–19. Springer Nature, 2022. https://doi.org/10.1007/978-3-030-94583-1_1.
ieee: E. Bartocci, T. Ferrere, T. A. Henzinger, D. Nickovic, and A. O. Da Costa,
“Flavors of sequential information flow,” in Lecture Notes in Computer Science
(including subseries Lecture Notes in Artificial Intelligence and Lecture Notes
in Bioinformatics), Philadelphia, PA, United States, 2022, vol. 13182, pp.
1–19.
ista: 'Bartocci E, Ferrere T, Henzinger TA, Nickovic D, Da Costa AO. 2022. Flavors
of sequential information flow. Lecture Notes in Computer Science (including subseries
Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics).
VMCAI: Verifcation, Model Checking, and Abstract Interpretation, LNCS, vol. 13182,
1–19.'
mla: Bartocci, Ezio, et al. “Flavors of Sequential Information Flow.” Lecture
Notes in Computer Science (Including Subseries Lecture Notes in Artificial Intelligence
and Lecture Notes in Bioinformatics), vol. 13182, Springer Nature, 2022, pp.
1–19, doi:10.1007/978-3-030-94583-1_1.
short: E. Bartocci, T. Ferrere, T.A. Henzinger, D. Nickovic, A.O. Da Costa, in:,
Lecture Notes in Computer Science (Including Subseries Lecture Notes in Artificial
Intelligence and Lecture Notes in Bioinformatics), Springer Nature, 2022, pp.
1–19.
conference:
end_date: 2022-01-18
location: Philadelphia, PA, United States
name: 'VMCAI: Verifcation, Model Checking, and Abstract Interpretation'
start_date: 2022-01-16
date_created: 2022-02-20T23:01:34Z
date_published: 2022-01-14T00:00:00Z
date_updated: 2022-08-05T09:02:56Z
day: '14'
department:
- _id: ToHe
doi: 10.1007/978-3-030-94583-1_1
external_id:
arxiv:
- '2105.02013'
intvolume: ' 13182'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: ' https://doi.org/10.48550/arXiv.2105.02013'
month: '01'
oa: 1
oa_version: Preprint
page: 1-19
project:
- _id: 25F42A32-B435-11E9-9278-68D0E5697425
call_identifier: FWF
grant_number: Z211
name: The Wittgenstein Prize
publication: Lecture Notes in Computer Science (including subseries Lecture Notes
in Artificial Intelligence and Lecture Notes in Bioinformatics)
publication_identifier:
eissn:
- '16113349'
isbn:
- '9783030945824'
issn:
- '03029743'
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
scopus_import: '1'
status: public
title: Flavors of sequential information flow
type: conference
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 13182
year: '2022'
...
---
_id: '10775'
abstract:
- lang: eng
text: List-decodability of Reed–Solomon codes has received a lot of attention, but
the best-possible dependence between the parameters is still not well-understood.
In this work, we focus on the case where the list-decoding radius is of the form
r = 1-ε for ε tending to zero. Our main result states that there exist Reed–Solomon
codes with rate Ω(ε) which are (1 - ε, O(1/ε))-list-decodable, meaning that any
Hamming ball of radius 1-ε contains at most O(1/ε) codewords. This trade-off between
rate and list-decoding radius is best-possible for any code with list size less
than exponential in the block length. By achieving this trade-off between rate
and list-decoding radius we improve a recent result of Guo, Li, Shangguan, Tamo,
and Wootters, and resolve the main motivating question of their work. Moreover,
while their result requires the field to be exponentially large in the block length,
we only need the field size to be polynomially large (and in fact, almost-linear
suffices). We deduce our main result from a more general theorem, in which we
prove good list-decodability properties of random puncturings of any given code
with very large distance.
acknowledgement: Research supported by NSF Award DMS-1953990.
article_processing_charge: No
article_type: original
arxiv: 1
author:
- first_name: Asaf
full_name: Ferber, Asaf
last_name: Ferber
- first_name: Matthew Alan
full_name: Kwan, Matthew Alan
id: 5fca0887-a1db-11eb-95d1-ca9d5e0453b3
last_name: Kwan
orcid: 0000-0002-4003-7567
- first_name: Lisa
full_name: Sauermann, Lisa
last_name: Sauermann
citation:
ama: Ferber A, Kwan MA, Sauermann L. List-decodability with large radius for Reed-Solomon
codes. IEEE Transactions on Information Theory. 2022;68(6):3823-3828. doi:10.1109/TIT.2022.3148779
apa: Ferber, A., Kwan, M. A., & Sauermann, L. (2022). List-decodability with
large radius for Reed-Solomon codes. IEEE Transactions on Information Theory.
IEEE. https://doi.org/10.1109/TIT.2022.3148779
chicago: Ferber, Asaf, Matthew Alan Kwan, and Lisa Sauermann. “List-Decodability
with Large Radius for Reed-Solomon Codes.” IEEE Transactions on Information
Theory. IEEE, 2022. https://doi.org/10.1109/TIT.2022.3148779.
ieee: A. Ferber, M. A. Kwan, and L. Sauermann, “List-decodability with large radius
for Reed-Solomon codes,” IEEE Transactions on Information Theory, vol.
68, no. 6. IEEE, pp. 3823–3828, 2022.
ista: Ferber A, Kwan MA, Sauermann L. 2022. List-decodability with large radius
for Reed-Solomon codes. IEEE Transactions on Information Theory. 68(6), 3823–3828.
mla: Ferber, Asaf, et al. “List-Decodability with Large Radius for Reed-Solomon
Codes.” IEEE Transactions on Information Theory, vol. 68, no. 6, IEEE,
2022, pp. 3823–28, doi:10.1109/TIT.2022.3148779.
short: A. Ferber, M.A. Kwan, L. Sauermann, IEEE Transactions on Information Theory
68 (2022) 3823–3828.
date_created: 2022-02-20T23:01:34Z
date_published: 2022-06-01T00:00:00Z
date_updated: 2023-08-03T06:57:01Z
day: '01'
department:
- _id: MaKw
doi: 10.1109/TIT.2022.3148779
external_id:
arxiv:
- '2012.10584'
isi:
- '000799622500022'
intvolume: ' 68'
isi: 1
issue: '6'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://arxiv.org/abs/2012.10584
month: '06'
oa: 1
oa_version: Preprint
page: 3823-3828
publication: IEEE Transactions on Information Theory
publication_identifier:
eissn:
- 1557-9654
issn:
- 0018-9448
publication_status: published
publisher: IEEE
quality_controlled: '1'
related_material:
record:
- id: '11145'
relation: earlier_version
status: public
scopus_import: '1'
status: public
title: List-decodability with large radius for Reed-Solomon codes
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 68
year: '2022'
...
---
_id: '10776'
abstract:
- lang: eng
text: 'Let K be a convex body in Rn (i.e., a compact convex set with nonempty interior).
Given a point p in the interior of K, a hyperplane h passing through p is called
barycentric if p is the barycenter of K∩h. In 1961, Grünbaum raised the question
whether, for every K, there exists an interior point p through which there are
at least n+1 distinct barycentric hyperplanes. Two years later, this was seemingly
resolved affirmatively by showing that this is the case if p=p0 is the point of
maximal depth in K. However, while working on a related question, we noticed that
one of the auxiliary claims in the proof is incorrect. Here, we provide a counterexample;
this re-opens Grünbaum’s question. It follows from known results that for n≥2,
there are always at least three distinct barycentric cuts through the point p0∈K
of maximal depth. Using tools related to Morse theory we are able to improve this
bound: four distinct barycentric cuts through p0 are guaranteed if n≥3.'
acknowledgement: The work by Zuzana Patáková has been partially supported by Charles
University Research Center Program No. UNCE/SCI/022, and part of it was done during
her research stay at IST Austria. The work by Martin Tancer is supported by the
GAČR Grant 19-04113Y and by the Charles University Projects PRIMUS/17/SCI/3 and
UNCE/SCI/004.
article_processing_charge: No
article_type: original
arxiv: 1
author:
- first_name: Zuzana
full_name: Patakova, Zuzana
id: 48B57058-F248-11E8-B48F-1D18A9856A87
last_name: Patakova
orcid: 0000-0002-3975-1683
- first_name: Martin
full_name: Tancer, Martin
last_name: Tancer
- first_name: Uli
full_name: Wagner, Uli
id: 36690CA2-F248-11E8-B48F-1D18A9856A87
last_name: Wagner
orcid: 0000-0002-1494-0568
citation:
ama: Patakova Z, Tancer M, Wagner U. Barycentric cuts through a convex body. Discrete
and Computational Geometry. 2022;68:1133-1154. doi:10.1007/s00454-021-00364-7
apa: Patakova, Z., Tancer, M., & Wagner, U. (2022). Barycentric cuts through
a convex body. Discrete and Computational Geometry. Springer Nature. https://doi.org/10.1007/s00454-021-00364-7
chicago: Patakova, Zuzana, Martin Tancer, and Uli Wagner. “Barycentric Cuts through
a Convex Body.” Discrete and Computational Geometry. Springer Nature, 2022.
https://doi.org/10.1007/s00454-021-00364-7.
ieee: Z. Patakova, M. Tancer, and U. Wagner, “Barycentric cuts through a convex
body,” Discrete and Computational Geometry, vol. 68. Springer Nature, pp.
1133–1154, 2022.
ista: Patakova Z, Tancer M, Wagner U. 2022. Barycentric cuts through a convex body.
Discrete and Computational Geometry. 68, 1133–1154.
mla: Patakova, Zuzana, et al. “Barycentric Cuts through a Convex Body.” Discrete
and Computational Geometry, vol. 68, Springer Nature, 2022, pp. 1133–54, doi:10.1007/s00454-021-00364-7.
short: Z. Patakova, M. Tancer, U. Wagner, Discrete and Computational Geometry 68
(2022) 1133–1154.
date_created: 2022-02-20T23:01:35Z
date_published: 2022-12-01T00:00:00Z
date_updated: 2023-08-02T14:38:58Z
day: '01'
department:
- _id: UlWa
doi: 10.1007/s00454-021-00364-7
external_id:
arxiv:
- '2003.13536'
isi:
- '000750681500001'
intvolume: ' 68'
isi: 1
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://arxiv.org/abs/2003.13536
month: '12'
oa: 1
oa_version: Preprint
page: 1133-1154
publication: Discrete and Computational Geometry
publication_identifier:
eissn:
- 1432-0444
issn:
- 0179-5376
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
scopus_import: '1'
status: public
title: Barycentric cuts through a convex body
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 68
year: '2022'
...
---
_id: '10787'
abstract:
- lang: eng
text: "A species distributed across diverse environments may adapt to local conditions.
We ask how quickly such a species changes its range in response to changed conditions.
Szép et al. (Szép E, Sachdeva H, Barton NH. 2021 Polygenic local adaptation in
metapopulations: a stochastic eco-evolutionary model. Evolution75, 1030–1045 (doi:10.1111/evo.14210))
used the infinite island model to find the stationary distribution of allele frequencies
and deme sizes. We extend this to find how a metapopulation responds to changes
in carrying capacity, selection strength, or migration rate when deme sizes are
fixed. We further develop a ‘fixed-state’ approximation. Under this approximation,
polymorphism is only possible for a narrow range of habitat proportions when selection
is weak compared to drift, but for a much wider range otherwise. When rates of
selection or migration relative to drift change in a single deme of the metapopulation,
the population takes a time of order m−1 to reach the new equilibrium. However,
even with many loci, there can be substantial fluctuations in net adaptation,
because at each locus, alleles randomly get lost or fixed. Thus, in a finite metapopulation,
variation may gradually be lost by chance, even if it would persist in an infinite
metapopulation. When conditions change across the whole metapopulation, there
can be rapid change, which is predicted well by the fixed-state approximation.
This work helps towards an understanding of how metapopulations extend their range
across diverse environments.\r\nThis article is part of the theme issue ‘Species’
ranges in the face of changing environments (Part II)’."
acknowledgement: This research was partly funded by the Austrian Science Fund (FWF)
[FWF P-32896B].
article_processing_charge: No
article_type: original
author:
- first_name: Nicholas H
full_name: Barton, Nicholas H
id: 4880FE40-F248-11E8-B48F-1D18A9856A87
last_name: Barton
orcid: 0000-0002-8548-5240
- first_name: Oluwafunmilola O
full_name: Olusanya, Oluwafunmilola O
id: 41AD96DC-F248-11E8-B48F-1D18A9856A87
last_name: Olusanya
orcid: 0000-0003-1971-8314
citation:
ama: 'Barton NH, Olusanya OO. The response of a metapopulation to a changing environment.
Philosophical Transactions of the Royal Society B: Biological Sciences.
2022;377(1848). doi:10.1098/rstb.2021.0009'
apa: 'Barton, N. H., & Olusanya, O. O. (2022). The response of a metapopulation
to a changing environment. Philosophical Transactions of the Royal Society
B: Biological Sciences. The Royal Society. https://doi.org/10.1098/rstb.2021.0009'
chicago: 'Barton, Nicholas H, and Oluwafunmilola O Olusanya. “The Response of a
Metapopulation to a Changing Environment.” Philosophical Transactions of the
Royal Society B: Biological Sciences. The Royal Society, 2022. https://doi.org/10.1098/rstb.2021.0009.'
ieee: 'N. H. Barton and O. O. Olusanya, “The response of a metapopulation to a changing
environment,” Philosophical Transactions of the Royal Society B: Biological
Sciences, vol. 377, no. 1848. The Royal Society, 2022.'
ista: 'Barton NH, Olusanya OO. 2022. The response of a metapopulation to a changing
environment. Philosophical Transactions of the Royal Society B: Biological Sciences.
377(1848).'
mla: 'Barton, Nicholas H., and Oluwafunmilola O. Olusanya. “The Response of a Metapopulation
to a Changing Environment.” Philosophical Transactions of the Royal Society
B: Biological Sciences, vol. 377, no. 1848, The Royal Society, 2022, doi:10.1098/rstb.2021.0009.'
short: 'N.H. Barton, O.O. Olusanya, Philosophical Transactions of the Royal Society
B: Biological Sciences 377 (2022).'
date_created: 2022-02-21T16:08:10Z
date_published: 2022-04-11T00:00:00Z
date_updated: 2025-05-26T09:05:09Z
day: '11'
ddc:
- '570'
department:
- _id: GradSch
- _id: NiBa
doi: 10.1098/rstb.2021.0009
external_id:
isi:
- '000758140300001'
pmid:
- '35184588'
file:
- access_level: open_access
checksum: 3b0243738f01bf3c07e0d7e8dc64f71d
content_type: application/pdf
creator: dernst
date_created: 2022-08-02T06:14:32Z
date_updated: 2022-08-02T06:14:32Z
file_id: '11719'
file_name: 2022_PhilosophicalTransactionsRSB_Barton.pdf
file_size: 1349672
relation: main_file
success: 1
file_date_updated: 2022-08-02T06:14:32Z
has_accepted_license: '1'
intvolume: ' 377'
isi: 1
issue: '1848'
keyword:
- General Agricultural and Biological Sciences
- General Biochemistry
- Genetics and Molecular Biology
language:
- iso: eng
month: '04'
oa: 1
oa_version: Published Version
pmid: 1
project:
- _id: c08d3278-5a5b-11eb-8a69-fdb09b55f4b8
grant_number: P32896
name: Causes and consequences of population fragmentation
publication: 'Philosophical Transactions of the Royal Society B: Biological Sciences'
publication_identifier:
eissn:
- 1471-2970
issn:
- 0962-8436
publication_status: published
publisher: The Royal Society
quality_controlled: '1'
related_material:
record:
- id: '14711'
relation: dissertation_contains
status: public
scopus_import: '1'
status: public
title: The response of a metapopulation to a changing environment
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: c635000d-4b10-11ee-a964-aac5a93f6ac1
volume: 377
year: '2022'
...
---
_id: '10788'
abstract:
- lang: eng
text: "We determine an asymptotic formula for the number of integral points of\r\nbounded
height on a certain toric variety, which is incompatible with part of a\r\npreprint
by Chambert-Loir and Tschinkel. We provide an alternative\r\ninterpretation of
the asymptotic formula we get. To do so, we construct an\r\nanalogue of Peyre's
constant $\\alpha$ and describe its relation to a new\r\nobstruction to the Zariski
density of integral points in certain regions of\r\nvarieties."
acknowledgement: "Part of this work was conducted as a guest at the Institut de Mathématiques
de Jussieu–Paris Rive Gauche invited by Antoine Chambert-Loir and funded by DAAD.\r\nDuring
this time, I had interesting and fruitful discussions on the interpretation of the
result for\r\nthe toric variety discussed in Section 3 with Antoine Chambert-Loir.
I wish to thank him for these\r\nopportunities and for his useful remarks on earlier
versions of this article. This work was partly\r\nfunded by FWF grant P 32428-N35."
article_number: '2202.10909'
article_processing_charge: No
arxiv: 1
author:
- first_name: Florian Alexander
full_name: Wilsch, Florian Alexander
id: 560601DA-8D36-11E9-A136-7AC1E5697425
last_name: Wilsch
orcid: 0000-0001-7302-8256
citation:
ama: Wilsch FA. Integral points of bounded height on a certain toric variety. arXiv.
doi:10.48550/arXiv.2202.10909
apa: Wilsch, F. A. (n.d.). Integral points of bounded height on a certain toric
variety. arXiv. https://doi.org/10.48550/arXiv.2202.10909
chicago: Wilsch, Florian Alexander. “Integral Points of Bounded Height on a Certain
Toric Variety.” ArXiv, n.d. https://doi.org/10.48550/arXiv.2202.10909.
ieee: F. A. Wilsch, “Integral points of bounded height on a certain toric variety,”
arXiv. .
ista: Wilsch FA. Integral points of bounded height on a certain toric variety. arXiv,
2202.10909.
mla: Wilsch, Florian Alexander. “Integral Points of Bounded Height on a Certain
Toric Variety.” ArXiv, 2202.10909, doi:10.48550/arXiv.2202.10909.
short: F.A. Wilsch, ArXiv (n.d.).
date_created: 2022-02-23T09:04:43Z
date_published: 2022-02-22T00:00:00Z
date_updated: 2023-05-03T07:46:35Z
day: '22'
department:
- _id: TiBr
doi: 10.48550/arXiv.2202.10909
external_id:
arxiv:
- '2202.10909'
keyword:
- Integral point
- toric variety
- Manin's conjecture
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://arxiv.org/abs/2202.10909
month: '02'
oa: 1
oa_version: Preprint
project:
- _id: 26AEDAB2-B435-11E9-9278-68D0E5697425
call_identifier: FWF
grant_number: P32428
name: New frontiers of the Manin conjecture
publication: arXiv
publication_status: submitted
status: public
title: Integral points of bounded height on a certain toric variety
type: preprint
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '2022'
...
---
_id: '10791'
abstract:
- lang: eng
text: The mammalian neocortex is composed of diverse neuronal and glial cell classes
that broadly arrange in six distinct laminae. Cortical layers emerge during development
and defects in the developmental programs that orchestrate cortical lamination
are associated with neurodevelopmental diseases. The developmental principle of
cortical layer formation depends on concerted radial projection neuron migration,
from their birthplace to their final target position. Radial migration occurs
in defined sequential steps, regulated by a large array of signaling pathways.
However, based on genetic loss-of-function experiments, most studies have thus
far focused on the role of cell-autonomous gene function. Yet, cortical neuron
migration in situ is a complex process and migrating neurons traverse along diverse
cellular compartments and environments. The role of tissue-wide properties and
genetic state in radial neuron migration is however not clear. Here we utilized
mosaic analysis with double markers (MADM) technology to either sparsely or globally
delete gene function, followed by quantitative single-cell phenotyping. The MADM-based
gene ablation paradigms in combination with computational modeling demonstrated
that global tissue-wide effects predominate cell-autonomous gene function albeit
in a gene-specific manner. Our results thus suggest that the genetic landscape
in a tissue critically affects the overall migration phenotype of individual cortical
projection neurons. In a broader context, our findings imply that global tissue-wide
effects represent an essential component of the underlying etiology associated
with focal malformations of cortical development in particular, and neurological
diseases in general.
acknowledged_ssus:
- _id: LifeSc
- _id: PreCl
- _id: Bio
acknowledgement: "A.H.H. was a recipient of a DOC Fellowship (24812) of the Austrian
Academy of Sciences. This work also received support from IST Austria institutional
funds; the People Programme (Marie Curie Actions) of the European Union’s Seventh
Framework Programme (FP7/2007–2013) under REA grant agreement No 618444 to S.H.\r\nAPC
funding was obtained by IST Austria institutional funds.\r\nWe thank A. Sommer and
C. Czepe (VBCF GmbH, NGS Unit), L. Andersen, J. Sonntag and J. Renno for technical
support and/or initial experiments; M. Sixt, J. Nimpf and all members of the Hippenmeyer
lab for discussion. This research was supported by the Scientific Service Units
of IST Austria through resources provided by the Imaging and Optics Facility, Lab
Support Facility and Preclinical Facility."
article_number: kvac009
article_processing_charge: No
article_type: original
author:
- first_name: Andi H
full_name: Hansen, Andi H
id: 38853E16-F248-11E8-B48F-1D18A9856A87
last_name: Hansen
- first_name: Florian
full_name: Pauler, Florian
id: 48EA0138-F248-11E8-B48F-1D18A9856A87
last_name: Pauler
orcid: 0000-0002-7462-0048
- first_name: Michael
full_name: Riedl, Michael
id: 3BE60946-F248-11E8-B48F-1D18A9856A87
last_name: Riedl
orcid: 0000-0003-4844-6311
- first_name: Carmen
full_name: Streicher, Carmen
id: 36BCB99C-F248-11E8-B48F-1D18A9856A87
last_name: Streicher
- first_name: Anna-Magdalena
full_name: Heger, Anna-Magdalena
id: 4B76FFD2-F248-11E8-B48F-1D18A9856A87
last_name: Heger
- first_name: Susanne
full_name: Laukoter, Susanne
id: 2D6B7A9A-F248-11E8-B48F-1D18A9856A87
last_name: Laukoter
orcid: 0000-0002-7903-3010
- first_name: Christoph M
full_name: Sommer, Christoph M
id: 4DF26D8C-F248-11E8-B48F-1D18A9856A87
last_name: Sommer
orcid: 0000-0003-1216-9105
- first_name: Armel
full_name: Nicolas, Armel
id: 2A103192-F248-11E8-B48F-1D18A9856A87
last_name: Nicolas
- first_name: Björn
full_name: Hof, Björn
id: 3A374330-F248-11E8-B48F-1D18A9856A87
last_name: Hof
orcid: 0000-0003-2057-2754
- first_name: Li Huei
full_name: Tsai, Li Huei
last_name: Tsai
- first_name: Thomas
full_name: Rülicke, Thomas
last_name: Rülicke
- first_name: Simon
full_name: Hippenmeyer, Simon
id: 37B36620-F248-11E8-B48F-1D18A9856A87
last_name: Hippenmeyer
orcid: 0000-0003-2279-1061
citation:
ama: Hansen AH, Pauler F, Riedl M, et al. Tissue-wide effects override cell-intrinsic
gene function in radial neuron migration. Oxford Open Neuroscience. 2022;1(1).
doi:10.1093/oons/kvac009
apa: Hansen, A. H., Pauler, F., Riedl, M., Streicher, C., Heger, A.-M., Laukoter,
S., … Hippenmeyer, S. (2022). Tissue-wide effects override cell-intrinsic gene
function in radial neuron migration. Oxford Open Neuroscience. Oxford Academic.
https://doi.org/10.1093/oons/kvac009
chicago: Hansen, Andi H, Florian Pauler, Michael Riedl, Carmen Streicher, Anna-Magdalena
Heger, Susanne Laukoter, Christoph M Sommer, et al. “Tissue-Wide Effects Override
Cell-Intrinsic Gene Function in Radial Neuron Migration.” Oxford Open Neuroscience.
Oxford Academic, 2022. https://doi.org/10.1093/oons/kvac009.
ieee: A. H. Hansen et al., “Tissue-wide effects override cell-intrinsic gene
function in radial neuron migration,” Oxford Open Neuroscience, vol. 1,
no. 1. Oxford Academic, 2022.
ista: Hansen AH, Pauler F, Riedl M, Streicher C, Heger A-M, Laukoter S, Sommer CM,
Nicolas A, Hof B, Tsai LH, Rülicke T, Hippenmeyer S. 2022. Tissue-wide effects
override cell-intrinsic gene function in radial neuron migration. Oxford Open
Neuroscience. 1(1), kvac009.
mla: Hansen, Andi H., et al. “Tissue-Wide Effects Override Cell-Intrinsic Gene Function
in Radial Neuron Migration.” Oxford Open Neuroscience, vol. 1, no. 1, kvac009,
Oxford Academic, 2022, doi:10.1093/oons/kvac009.
short: A.H. Hansen, F. Pauler, M. Riedl, C. Streicher, A.-M. Heger, S. Laukoter,
C.M. Sommer, A. Nicolas, B. Hof, L.H. Tsai, T. Rülicke, S. Hippenmeyer, Oxford
Open Neuroscience 1 (2022).
date_created: 2022-02-25T07:52:11Z
date_published: 2022-07-07T00:00:00Z
date_updated: 2023-11-30T10:55:12Z
day: '07'
ddc:
- '570'
department:
- _id: SiHi
- _id: BjHo
- _id: LifeSc
- _id: EM-Fac
doi: 10.1093/oons/kvac009
ec_funded: 1
file:
- access_level: open_access
checksum: 822e76e056c07099d1fb27d1ece5941b
content_type: application/pdf
creator: dernst
date_created: 2023-08-16T08:00:30Z
date_updated: 2023-08-16T08:00:30Z
file_id: '14061'
file_name: 2023_OxfordOpenNeuroscience_Hansen.pdf
file_size: 4846551
relation: main_file
success: 1
file_date_updated: 2023-08-16T08:00:30Z
has_accepted_license: '1'
intvolume: ' 1'
issue: '1'
language:
- iso: eng
month: '07'
oa: 1
oa_version: Published Version
project:
- _id: 25D61E48-B435-11E9-9278-68D0E5697425
call_identifier: FP7
grant_number: '618444'
name: Molecular Mechanisms of Cerebral Cortex Development
- _id: 2625A13E-B435-11E9-9278-68D0E5697425
grant_number: '24812'
name: Molecular Mechanisms of Radial Neuronal Migration
publication: Oxford Open Neuroscience
publication_identifier:
eissn:
- 2753-149X
publication_status: published
publisher: Oxford Academic
quality_controlled: '1'
related_material:
record:
- id: '12726'
relation: dissertation_contains
status: public
- id: '14530'
relation: dissertation_contains
status: public
status: public
title: Tissue-wide effects override cell-intrinsic gene function in radial neuron
migration
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 1
year: '2022'
...
---
_id: '10792'
abstract:
- lang: eng
text: "Background\r\nProper cerebral cortical development depends on the tightly
orchestrated migration of newly born neurons from the inner ventricular and subventricular
zones to the outer cortical plate. Any disturbance in this process during prenatal
stages may lead to neuronal migration disorders (NMDs), which can vary in extent
from focal to global. Furthermore, NMDs show a substantial comorbidity with other
neurodevelopmental disorders, notably autism spectrum disorders (ASDs). Our previous
work demonstrated focal neuronal migration defects in mice carrying loss-of-function
alleles of the recognized autism risk gene WDFY3. However, the cellular origins
of these defects in Wdfy3 mutant mice remain elusive and uncovering it will provide
critical insight into WDFY3-dependent disease pathology .\r\nMethods\r\nHere,
in an effort to untangle the origins of NMDs in Wdfy3lacZ mice, we employed mosaic
analysis with double markers (MADM). MADM technology enabled us to genetically
distinctly track and phenotypically analyze mutant and wild type cells concomitantly
in vivo using immunofluorescent techniques.\r\nResults\r\nWe revealed a cell autonomous
requirement of WDFY3 for accurate laminar positioning of cortical projection neurons
and elimination of mispositioned cells during early postnatal life. In addition,
we identified significant deviations in dendritic arborization, as well as synaptic
density and morphology between wild type, heterozygous, and homozygous Wdfy3 mutant
neurons in Wdfy3-MADM reporter mice at postnatal stages. Limitations While Wdfy3
mutant mice have provided valuable insight into prenatal aspects of ASD pathology
that remain inaccessible to investigation in humans, like most animal models,
they do not a perfectly replicate all aspects of human ASD biology. The lack of
human data makes it indeterminate whether morphological deviations described here
apply to ASD patients.\r\nConclusions\r\n\uFEFFOur genetic approach revealed several
cell autonomous requirements of Wdfy3 in neuronal development that could underly
the pathogenic mechanisms of WDFY3-related ASD conditions. The results are also
consistent with findings in other ASD animal models and patients and suggest an
important role for Wdfy3 in regulating neuronal function and interconnectivity
in postnatal life."
article_processing_charge: No
author:
- first_name: Zachary
full_name: Schaaf, Zachary
last_name: Schaaf
- first_name: Lyvin
full_name: Tat, Lyvin
last_name: Tat
- first_name: Noemi
full_name: Cannizzaro, Noemi
last_name: Cannizzaro
- first_name: Ralph
full_name: Green, Ralph
last_name: Green
- first_name: Thomas
full_name: Rülicke, Thomas
last_name: Rülicke
- first_name: Simon
full_name: Hippenmeyer, Simon
id: 37B36620-F248-11E8-B48F-1D18A9856A87
last_name: Hippenmeyer
orcid: 0000-0003-2279-1061
- first_name: K
full_name: Zarbalis, K
last_name: Zarbalis
citation:
ama: Schaaf Z, Tat L, Cannizzaro N, et al. WDFY3 cell autonomously controls neuronal
migration. doi:10.21203/rs.3.rs-1316167/v1
apa: Schaaf, Z., Tat, L., Cannizzaro, N., Green, R., Rülicke, T., Hippenmeyer, S.,
& Zarbalis, K. (n.d.). WDFY3 cell autonomously controls neuronal migration.
Research Square. https://doi.org/10.21203/rs.3.rs-1316167/v1
chicago: Schaaf, Zachary, Lyvin Tat, Noemi Cannizzaro, Ralph Green, Thomas Rülicke,
Simon Hippenmeyer, and K Zarbalis. “WDFY3 Cell Autonomously Controls Neuronal
Migration.” Research Square, n.d. https://doi.org/10.21203/rs.3.rs-1316167/v1.
ieee: Z. Schaaf et al., “WDFY3 cell autonomously controls neuronal migration.”
Research Square.
ista: Schaaf Z, Tat L, Cannizzaro N, Green R, Rülicke T, Hippenmeyer S, Zarbalis
K. WDFY3 cell autonomously controls neuronal migration. 10.21203/rs.3.rs-1316167/v1.
mla: Schaaf, Zachary, et al. WDFY3 Cell Autonomously Controls Neuronal Migration.
Research Square, doi:10.21203/rs.3.rs-1316167/v1.
short: Z. Schaaf, L. Tat, N. Cannizzaro, R. Green, T. Rülicke, S. Hippenmeyer, K.
Zarbalis, (n.d.).
date_created: 2022-02-25T07:53:26Z
date_published: 2022-02-16T00:00:00Z
date_updated: 2023-10-17T13:06:52Z
day: '16'
department:
- _id: SiHi
doi: 10.21203/rs.3.rs-1316167/v1
external_id:
pmid:
- PPR454733
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://doi.org/10.21203/rs.3.rs-1316167/v1
month: '02'
oa: 1
oa_version: Preprint
page: '30'
pmid: 1
publication_identifier:
eissn:
- 2693-5015
publication_status: submitted
publisher: Research Square
status: public
title: WDFY3 cell autonomously controls neuronal migration
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: preprint
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '2022'
...
---
_id: '10797'
abstract:
- lang: eng
text: We consider symmetric partial exclusion and inclusion processes in a general
graph in contact with reservoirs, where we allow both for edge disorder and well-chosen
site disorder. We extend the classical dualities to this context and then we derive
new orthogonal polynomial dualities. From the classical dualities, we derive the
uniqueness of the non-equilibrium steady state and obtain correlation inequalities.
Starting from the orthogonal polynomial dualities, we show universal properties
of n-point correlation functions in the non-equilibrium steady state for systems
with at most two different reservoir parameters, such as a chain with reservoirs
at left and right ends.
- lang: fre
text: Nous considérons des processus d’exclusion partielle, et des processus d’inclusion
sur un graphe général en contact avec des réservoirs. Nous autorisons la présence
de inhomogenéités sur les arrêts ainsi que sur les sommets du graph. Nous généralisons
les “dualités classiques” dans ce contexte et nous démontrons des nouvelles dualités
orthogonales. À partir des dualités classiques, nous démontrons l’unicité de l’état
stationnaire non-équilibre, ainsi que des inégalités de corrélation. À partir
des dualités orthogonales nous démontrons des propriétés universelles des fonctions
de corrélation à n points dans l’état stationnaire non-équilibre pour des systèmes
avec deux paramètres de réservoirs inégaux, comme par exemple une chaîne avec
des réservoirs à droite et à gauche.
acknowledgement: The authors would like to thank Gioia Carinci and Cristian Giardinà
for useful discussions. F.R. and S.F. thank Jean-René Chazottes for a stay at CPHT
(Institut Polytechnique de Paris), in the realm of Chaire d’Alembert (Paris-Saclay
University), where part of this work was performed. S.F. acknowledges Simona Villa
for her support in creating the picture. S.F. acknowledges financial support from
NWO via the grant TOP1.17.019. F.S. acknowledges financial support from the European
Union’s Horizon 2020 research and innovation programme under the Marie-Skłodowska-Curie
grant agreement No. 754411.
article_processing_charge: No
article_type: original
arxiv: 1
author:
- first_name: Simone
full_name: Floreani, Simone
last_name: Floreani
- first_name: Frank
full_name: Redig, Frank
last_name: Redig
- first_name: Federico
full_name: Sau, Federico
id: E1836206-9F16-11E9-8814-AEFDE5697425
last_name: Sau
citation:
ama: Floreani S, Redig F, Sau F. Orthogonal polynomial duality of boundary driven
particle systems and non-equilibrium correlations. Annales de l’institut Henri
Poincare (B) Probability and Statistics. 2022;58(1):220-247. doi:10.1214/21-AIHP1163
apa: Floreani, S., Redig, F., & Sau, F. (2022). Orthogonal polynomial duality
of boundary driven particle systems and non-equilibrium correlations. Annales
de l’institut Henri Poincare (B) Probability and Statistics. Institute of
Mathematical Statistics. https://doi.org/10.1214/21-AIHP1163
chicago: Floreani, Simone, Frank Redig, and Federico Sau. “Orthogonal Polynomial
Duality of Boundary Driven Particle Systems and Non-Equilibrium Correlations.”
Annales de l’institut Henri Poincare (B) Probability and Statistics. Institute
of Mathematical Statistics, 2022. https://doi.org/10.1214/21-AIHP1163.
ieee: S. Floreani, F. Redig, and F. Sau, “Orthogonal polynomial duality of boundary
driven particle systems and non-equilibrium correlations,” Annales de l’institut
Henri Poincare (B) Probability and Statistics, vol. 58, no. 1. Institute of
Mathematical Statistics, pp. 220–247, 2022.
ista: Floreani S, Redig F, Sau F. 2022. Orthogonal polynomial duality of boundary
driven particle systems and non-equilibrium correlations. Annales de l’institut
Henri Poincare (B) Probability and Statistics. 58(1), 220–247.
mla: Floreani, Simone, et al. “Orthogonal Polynomial Duality of Boundary Driven
Particle Systems and Non-Equilibrium Correlations.” Annales de l’institut Henri
Poincare (B) Probability and Statistics, vol. 58, no. 1, Institute of Mathematical
Statistics, 2022, pp. 220–47, doi:10.1214/21-AIHP1163.
short: S. Floreani, F. Redig, F. Sau, Annales de l’institut Henri Poincare (B) Probability
and Statistics 58 (2022) 220–247.
date_created: 2022-02-27T23:01:50Z
date_published: 2022-02-01T00:00:00Z
date_updated: 2023-10-17T12:49:43Z
day: '01'
department:
- _id: JaMa
doi: 10.1214/21-AIHP1163
ec_funded: 1
external_id:
arxiv:
- '2007.08272'
isi:
- '000752489300010'
intvolume: ' 58'
isi: 1
issue: '1'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://arxiv.org/abs/2007.08272
month: '02'
oa: 1
oa_version: Preprint
page: 220-247
project:
- _id: 260C2330-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '754411'
name: ISTplus - Postdoctoral Fellowships
publication: Annales de l'institut Henri Poincare (B) Probability and Statistics
publication_identifier:
issn:
- 0246-0203
publication_status: published
publisher: Institute of Mathematical Statistics
quality_controlled: '1'
scopus_import: '1'
status: public
title: Orthogonal polynomial duality of boundary driven particle systems and non-equilibrium
correlations
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 58
year: '2022'
...
---
_id: '10799'
abstract:
- lang: eng
text: "Because of the increasing popularity of machine learning methods, it is becoming
important to understand the impact of learned components on automated decision-making
systems and to guarantee that their consequences are beneficial to society. In
other words, it is necessary to ensure that machine learning is sufficiently trustworthy
to be used in real-world applications. This thesis studies two properties of machine
learning models that are highly desirable for the\r\nsake of reliability: robustness
and fairness. In the first part of the thesis we study the robustness of learning
algorithms to training data corruption. Previous work has shown that machine learning
models are vulnerable to a range\r\nof training set issues, varying from label
noise through systematic biases to worst-case data manipulations. This is an especially
relevant problem from a present perspective, since modern machine learning methods
are particularly data hungry and therefore practitioners often have to rely on
data collected from various external sources, e.g. from the Internet, from app
users or via crowdsourcing. Naturally, such sources vary greatly in the quality
and reliability of the\r\ndata they provide. With these considerations in mind,
we study the problem of designing machine learning algorithms that are robust
to corruptions in data coming from multiple sources. We show that, in contrast
to the case of a single dataset with outliers, successful learning within this
model is possible both theoretically and practically, even under worst-case data
corruptions. The second part of this thesis deals with fairness-aware machine
learning. There are multiple areas where machine learning models have shown promising
results, but where careful considerations are required, in order to avoid discrimanative
decisions taken by such learned components. Ensuring fairness can be particularly
challenging, because real-world training datasets are expected to contain various
forms of historical bias that may affect the learning process. In this thesis
we show that data corruption can indeed render the problem of achieving fairness
impossible, by tightly characterizing the theoretical limits of fair learning
under worst-case data manipulations. However, assuming access to clean data, we
also show how fairness-aware learning can be made practical in contexts beyond
binary classification, in particular in the challenging learning to rank setting."
alternative_title:
- ISTA Thesis
article_processing_charge: No
author:
- first_name: Nikola H
full_name: Konstantinov, Nikola H
id: 4B9D76E4-F248-11E8-B48F-1D18A9856A87
last_name: Konstantinov
citation:
ama: Konstantinov NH. Robustness and fairness in machine learning. 2022. doi:10.15479/at:ista:10799
apa: Konstantinov, N. H. (2022). Robustness and fairness in machine learning.
Institute of Science and Technology Austria. https://doi.org/10.15479/at:ista:10799
chicago: Konstantinov, Nikola H. “Robustness and Fairness in Machine Learning.”
Institute of Science and Technology Austria, 2022. https://doi.org/10.15479/at:ista:10799.
ieee: N. H. Konstantinov, “Robustness and fairness in machine learning,” Institute
of Science and Technology Austria, 2022.
ista: Konstantinov NH. 2022. Robustness and fairness in machine learning. Institute
of Science and Technology Austria.
mla: Konstantinov, Nikola H. Robustness and Fairness in Machine Learning.
Institute of Science and Technology Austria, 2022, doi:10.15479/at:ista:10799.
short: N.H. Konstantinov, Robustness and Fairness in Machine Learning, Institute
of Science and Technology Austria, 2022.
date_created: 2022-02-28T13:03:49Z
date_published: 2022-03-08T00:00:00Z
date_updated: 2023-10-17T12:31:54Z
day: '08'
ddc:
- '000'
degree_awarded: PhD
department:
- _id: GradSch
- _id: ChLa
doi: 10.15479/at:ista:10799
ec_funded: 1
file:
- access_level: open_access
checksum: 626bc523ae8822d20e635d0e2d95182e
content_type: application/pdf
creator: nkonstan
date_created: 2022-03-06T11:42:54Z
date_updated: 2022-03-06T11:42:54Z
file_id: '10823'
file_name: thesis.pdf
file_size: 4204905
relation: main_file
success: 1
- access_level: closed
checksum: e2ca2b88350ac8ea1515b948885cbcb1
content_type: application/x-zip-compressed
creator: nkonstan
date_created: 2022-03-06T11:42:57Z
date_updated: 2022-03-10T12:11:48Z
file_id: '10824'
file_name: thesis.zip
file_size: 22841103
relation: source_file
file_date_updated: 2022-03-10T12:11:48Z
has_accepted_license: '1'
keyword:
- robustness
- fairness
- machine learning
- PAC learning
- adversarial learning
language:
- iso: eng
month: '03'
oa: 1
oa_version: Published Version
page: '176'
project:
- _id: 2564DBCA-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '665385'
name: International IST Doctoral Program
publication_identifier:
isbn:
- 978-3-99078-015-2
issn:
- 2663-337X
publication_status: published
publisher: Institute of Science and Technology Austria
related_material:
record:
- id: '8724'
relation: part_of_dissertation
status: public
- id: '10803'
relation: part_of_dissertation
status: public
- id: '10802'
relation: part_of_dissertation
status: public
- id: '6590'
relation: part_of_dissertation
status: public
status: public
supervisor:
- first_name: Christoph
full_name: Lampert, Christoph
id: 40C20FD2-F248-11E8-B48F-1D18A9856A87
last_name: Lampert
orcid: 0000-0001-8622-7887
title: Robustness and fairness in machine learning
type: dissertation
user_id: c635000d-4b10-11ee-a964-aac5a93f6ac1
year: '2022'
...
---
_id: '10802'
abstract:
- lang: eng
text: "Addressing fairness concerns about machine learning models is a crucial step
towards their long-term adoption in real-world automated systems. While many approaches
have been developed for training fair models from data, little is known about
the robustness of these methods to data corruption. In this work we consider fairness-aware
learning under worst-case data manipulations. We show that an adversary can in
some situations force any learner to return an overly biased classifier, regardless
of the sample size and with or without degrading\r\naccuracy, and that the strength
of the excess bias increases for learning problems with underrepresented protected
groups in the data. We also prove that our hardness results are tight up to constant
factors. To this end, we study two natural learning algorithms that optimize for
both accuracy and fairness and show that these algorithms enjoy guarantees that
are order-optimal in terms of the corruption ratio and the protected groups frequencies
in the large data\r\nlimit."
acknowledgement: The authors thank Eugenia Iofinova and Bernd Prach for providing
feedback on early versions of this paper. This publication was made possible by
an ETH AI Center postdoctoral fellowship to Nikola Konstantinov.
article_processing_charge: No
article_type: original
arxiv: 1
author:
- first_name: Nikola H
full_name: Konstantinov, Nikola H
id: 4B9D76E4-F248-11E8-B48F-1D18A9856A87
last_name: Konstantinov
- first_name: Christoph
full_name: Lampert, Christoph
id: 40C20FD2-F248-11E8-B48F-1D18A9856A87
last_name: Lampert
orcid: 0000-0002-4561-241X
citation:
ama: Konstantinov NH, Lampert C. Fairness-aware PAC learning from corrupted data.
Journal of Machine Learning Research. 2022;23:1-60.
apa: Konstantinov, N. H., & Lampert, C. (2022). Fairness-aware PAC learning
from corrupted data. Journal of Machine Learning Research. ML Research
Press.
chicago: Konstantinov, Nikola H, and Christoph Lampert. “Fairness-Aware PAC Learning
from Corrupted Data.” Journal of Machine Learning Research. ML Research
Press, 2022.
ieee: N. H. Konstantinov and C. Lampert, “Fairness-aware PAC learning from corrupted
data,” Journal of Machine Learning Research, vol. 23. ML Research Press,
pp. 1–60, 2022.
ista: Konstantinov NH, Lampert C. 2022. Fairness-aware PAC learning from corrupted
data. Journal of Machine Learning Research. 23, 1–60.
mla: Konstantinov, Nikola H., and Christoph Lampert. “Fairness-Aware PAC Learning
from Corrupted Data.” Journal of Machine Learning Research, vol. 23, ML
Research Press, 2022, pp. 1–60.
short: N.H. Konstantinov, C. Lampert, Journal of Machine Learning Research 23 (2022)
1–60.
date_created: 2022-02-28T14:05:42Z
date_published: 2022-05-01T00:00:00Z
date_updated: 2023-09-26T10:44:37Z
day: '01'
ddc:
- '004'
department:
- _id: ChLa
external_id:
arxiv:
- '2102.06004'
file:
- access_level: open_access
checksum: 9cac897b54a0ddf3a553a2c33e88cfda
content_type: application/pdf
creator: kschuh
date_created: 2022-07-12T15:08:28Z
date_updated: 2022-07-12T15:08:28Z
file_id: '11570'
file_name: 2022_JournalMachineLearningResearch_Konstantinov.pdf
file_size: 551862
relation: main_file
success: 1
file_date_updated: 2022-07-12T15:08:28Z
has_accepted_license: '1'
intvolume: ' 23'
keyword:
- Fairness
- robustness
- data poisoning
- trustworthy machine learning
- PAC learning
language:
- iso: eng
month: '05'
oa: 1
oa_version: Published Version
page: 1-60
publication: Journal of Machine Learning Research
publication_identifier:
eissn:
- 1533-7928
issn:
- 1532-4435
publication_status: published
publisher: ML Research Press
quality_controlled: '1'
related_material:
record:
- id: '10799'
relation: dissertation_contains
status: public
- id: '13241'
relation: shorter_version
status: public
scopus_import: '1'
status: public
title: Fairness-aware PAC learning from corrupted data
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 23
year: '2022'
...
---
_id: '10812'
abstract:
- lang: eng
text: Several promising strategies based on combining or cycling different antibiotics
have been proposed to increase efficacy and counteract resistance evolution, but
we still lack a deep understanding of the physiological responses and genetic
mechanisms that underlie antibiotic interactions and the clinical applicability
of these strategies. In antibiotic-exposed bacteria, the combined effects of physiological
stress responses and emerging resistance mutations (occurring at different time
scales) generate complex and often unpredictable dynamics. In this Review, we
present our current understanding of bacterial cell physiology and genetics of
responses to antibiotics. We emphasize recently discovered mechanisms of synergistic
and antagonistic drug interactions, hysteresis in temporal interactions between
antibiotics that arise from microbial physiology and interactions between antibiotics
and resistance mutations that can cause collateral sensitivity or cross-resistance.
We discuss possible connections between the different phenomena and indicate relevant
research directions. A better and more unified understanding of drug and genetic
interactions is likely to advance antibiotic therapy.
acknowledgement: The authors thank B. Kavčič and H. Schulenburg for constructive feedback
on the manuscript.
article_processing_charge: No
article_type: review
author:
- first_name: Roderich
full_name: Römhild, Roderich
id: 68E56E44-62B0-11EA-B963-444F3DDC885E
last_name: Römhild
orcid: 0000-0001-9480-5261
- first_name: Mark Tobias
full_name: Bollenbach, Mark Tobias
id: 3E6DB97A-F248-11E8-B48F-1D18A9856A87
last_name: Bollenbach
orcid: 0000-0003-4398-476X
- first_name: Dan I.
full_name: Andersson, Dan I.
last_name: Andersson
citation:
ama: Römhild R, Bollenbach MT, Andersson DI. The physiology and genetics of bacterial
responses to antibiotic combinations. Nature Reviews Microbiology. 2022;20:478-490.
doi:10.1038/s41579-022-00700-5
apa: Römhild, R., Bollenbach, M. T., & Andersson, D. I. (2022). The physiology
and genetics of bacterial responses to antibiotic combinations. Nature Reviews
Microbiology. Springer Nature. https://doi.org/10.1038/s41579-022-00700-5
chicago: Römhild, Roderich, Mark Tobias Bollenbach, and Dan I. Andersson. “The Physiology
and Genetics of Bacterial Responses to Antibiotic Combinations.” Nature Reviews
Microbiology. Springer Nature, 2022. https://doi.org/10.1038/s41579-022-00700-5.
ieee: R. Römhild, M. T. Bollenbach, and D. I. Andersson, “The physiology and genetics
of bacterial responses to antibiotic combinations,” Nature Reviews Microbiology,
vol. 20. Springer Nature, pp. 478–490, 2022.
ista: Römhild R, Bollenbach MT, Andersson DI. 2022. The physiology and genetics
of bacterial responses to antibiotic combinations. Nature Reviews Microbiology.
20, 478–490.
mla: Römhild, Roderich, et al. “The Physiology and Genetics of Bacterial Responses
to Antibiotic Combinations.” Nature Reviews Microbiology, vol. 20, Springer
Nature, 2022, pp. 478–90, doi:10.1038/s41579-022-00700-5.
short: R. Römhild, M.T. Bollenbach, D.I. Andersson, Nature Reviews Microbiology
20 (2022) 478–490.
date_created: 2022-03-04T04:33:49Z
date_published: 2022-08-01T00:00:00Z
date_updated: 2023-08-02T14:41:44Z
day: '01'
department:
- _id: CaGu
doi: 10.1038/s41579-022-00700-5
external_id:
isi:
- '000763891900001'
pmid:
- '35241807'
intvolume: ' 20'
isi: 1
keyword:
- General Immunology and Microbiology
- Microbiology
- Infectious Diseases
language:
- iso: eng
month: '08'
oa_version: None
page: 478-490
pmid: 1
publication: Nature Reviews Microbiology
publication_identifier:
eissn:
- 1740-1534
issn:
- 1740-1526
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
scopus_import: '1'
status: public
title: The physiology and genetics of bacterial responses to antibiotic combinations
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 20
year: '2022'
...