---
_id: '12760'
abstract:
- lang: eng
  text: "Dynamic programming (DP) is one of the fundamental paradigms in algorithm
    design. However,\r\nmany DP algorithms have to fill in large DP tables, represented
    by two-dimensional arrays, which causes at least quadratic running times and space
    usages. This has led to the development of improved algorithms for special cases
    when the DPs satisfy additional properties like, e.g., the Monge property or total
    monotonicity.\r\nIn this paper, we consider a new condition which assumes (among
    some other technical assumptions) that the rows of the DP table are monotone.
    Under this assumption, we introduce\r\na novel data structure for computing (1
    + ϵ)-approximate DP solutions in near-linear time and\r\nspace in the static setting,
    and with polylogarithmic update times when the DP entries change\r\ndynamically.
    To the best of our knowledge, our new condition is incomparable to previous conditions
    and is the first which allows to derive dynamic algorithms based on existing DPs.
    Instead of using two-dimensional arrays to store the DP tables, we store the rows
    of the DP tables using monotone piecewise constant functions. This allows us to
    store length-n DP table rows with entries in [0, W] using only polylog(n, W) bits,
    and to perform operations, such as (min, +)-convolution or rounding, on these
    functions in polylogarithmic time.\r\nWe further present several applications
    of our data structure. For bicriteria versions of k-balanced graph partitioning
    and simultaneous source location, we obtain the first dynamic algorithms with
    subpolynomial update times, as well as the first static algorithms using only
    near-linear time and space. Additionally, we obtain the currently fastest algorithm
    for fully dynamic knapsack."
acknowledgement: "Monika Henzinger: This project has received funding from the European
  Research Council\r\n(ERC) under the European Union’s Horizon 2020 research and innovation
  programme (Grant\r\nagreement No. 101019564 “The Design of Modern Fully Dynamic
  Data Structures (MoDynStruct)” and from the Austrian Science Fund (FWF) project
  “Fast Algorithms for a Reactive Network Layer (ReactNet)”, P 33775-N, with additional
  funding from the netidee SCIENCE Stiftung, 2020–2024.\r\nStefan Neumann: This research
  is supported by the the ERC Advanced Grant REBOUND (834862) and the EC H2020 RIA
  project SoBigData++ (871042).\r\nStefan Schmid: Research supported by Austrian Science
  Fund (FWF) project I 5025-N (DELTA), 2020-2024."
alternative_title:
- LIPIcs
article_number: '36'
article_processing_charge: No
arxiv: 1
author:
- first_name: Monika H
  full_name: Henzinger, Monika H
  id: 540c9bbd-f2de-11ec-812d-d04a5be85630
  last_name: Henzinger
  orcid: 0000-0002-5008-6530
- first_name: Stefan
  full_name: Neumann, Stefan
  last_name: Neumann
- first_name: Harald
  full_name: Räcke, Harald
  last_name: Räcke
- first_name: Stefan
  full_name: Schmid, Stefan
  last_name: Schmid
citation:
  ama: 'Henzinger MH, Neumann S, Räcke H, Schmid S. Dynamic maintenance of monotone
    dynamic programs and applications. In: <i>40th International Symposium on Theoretical
    Aspects of Computer Science</i>. Vol 254. Schloss Dagstuhl - Leibniz-Zentrum für
    Informatik; 2023. doi:<a href="https://doi.org/10.4230/LIPIcs.STACS.2023.36">10.4230/LIPIcs.STACS.2023.36</a>'
  apa: 'Henzinger, M. H., Neumann, S., Räcke, H., &#38; Schmid, S. (2023). Dynamic
    maintenance of monotone dynamic programs and applications. In <i>40th International
    Symposium on Theoretical Aspects of Computer Science</i> (Vol. 254). Hamburg,
    Germany: Schloss Dagstuhl - Leibniz-Zentrum für Informatik. <a href="https://doi.org/10.4230/LIPIcs.STACS.2023.36">https://doi.org/10.4230/LIPIcs.STACS.2023.36</a>'
  chicago: Henzinger, Monika H, Stefan Neumann, Harald Räcke, and Stefan Schmid. “Dynamic
    Maintenance of Monotone Dynamic Programs and Applications.” In <i>40th International
    Symposium on Theoretical Aspects of Computer Science</i>, Vol. 254. Schloss Dagstuhl
    - Leibniz-Zentrum für Informatik, 2023. <a href="https://doi.org/10.4230/LIPIcs.STACS.2023.36">https://doi.org/10.4230/LIPIcs.STACS.2023.36</a>.
  ieee: M. H. Henzinger, S. Neumann, H. Räcke, and S. Schmid, “Dynamic maintenance
    of monotone dynamic programs and applications,” in <i>40th International Symposium
    on Theoretical Aspects of Computer Science</i>, Hamburg, Germany, 2023, vol. 254.
  ista: 'Henzinger MH, Neumann S, Räcke H, Schmid S. 2023. Dynamic maintenance of
    monotone dynamic programs and applications. 40th International Symposium on Theoretical
    Aspects of Computer Science. STACS: Symposium on Theoretical Aspects of Computer
    Science, LIPIcs, vol. 254, 36.'
  mla: Henzinger, Monika H., et al. “Dynamic Maintenance of Monotone Dynamic Programs
    and Applications.” <i>40th International Symposium on Theoretical Aspects of Computer
    Science</i>, vol. 254, 36, Schloss Dagstuhl - Leibniz-Zentrum für Informatik,
    2023, doi:<a href="https://doi.org/10.4230/LIPIcs.STACS.2023.36">10.4230/LIPIcs.STACS.2023.36</a>.
  short: M.H. Henzinger, S. Neumann, H. Räcke, S. Schmid, in:, 40th International
    Symposium on Theoretical Aspects of Computer Science, Schloss Dagstuhl - Leibniz-Zentrum
    für Informatik, 2023.
conference:
  end_date: 2023-03-09
  location: Hamburg, Germany
  name: 'STACS: Symposium on Theoretical Aspects of Computer Science'
  start_date: 2023-03-07
date_created: 2023-03-26T22:01:07Z
date_published: 2023-03-01T00:00:00Z
date_updated: 2023-03-27T06:46:27Z
day: '01'
ddc:
- '000'
department:
- _id: MoHe
doi: 10.4230/LIPIcs.STACS.2023.36
external_id:
  arxiv:
  - '2301.01744'
file:
- access_level: open_access
  checksum: 22141ab8bc55188e2dfff665e5daecbd
  content_type: application/pdf
  creator: dernst
  date_created: 2023-03-27T06:37:22Z
  date_updated: 2023-03-27T06:37:22Z
  file_id: '12769'
  file_name: 2023_LIPICS_HenzingerM.pdf
  file_size: 872706
  relation: main_file
  success: 1
file_date_updated: 2023-03-27T06:37:22Z
has_accepted_license: '1'
intvolume: '       254'
language:
- iso: eng
month: '03'
oa: 1
oa_version: Published Version
publication: 40th International Symposium on Theoretical Aspects of Computer Science
publication_identifier:
  isbn:
  - '9783959772662'
  issn:
  - 1868-8969
publication_status: published
publisher: Schloss Dagstuhl - Leibniz-Zentrum für Informatik
quality_controlled: '1'
scopus_import: '1'
status: public
title: Dynamic maintenance of monotone dynamic programs and applications
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: conference
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 254
year: '2023'
...
---
_id: '12761'
abstract:
- lang: eng
  text: "We consider the fluctuations of regular functions f of a Wigner matrix W
    viewed as an entire matrix f (W). Going beyond the well-studied tracial mode,
    Trf (W), which is equivalent to the customary linear statistics of eigenvalues,
    we show that Trf (W)A is asymptotically normal for any nontrivial bounded deterministic
    matrix A. We identify three different and asymptotically independent modes of
    this fluctuation, corresponding to the tracial part, the traceless diagonal part
    and the off-diagonal part of f (W) in the entire mesoscopic regime, where we find
    that the off-diagonal modes fluctuate on a much smaller scale than the tracial
    mode. As a main motivation to study CLT in such generality on small mesoscopic
    scales, we determine\r\nthe fluctuations in the eigenstate thermalization hypothesis
    (Phys. Rev. A 43 (1991) 2046–2049), that is, prove that the eigenfunction overlaps
    with any deterministic matrix are asymptotically Gaussian after a small spectral
    averaging. Finally, in the macroscopic regime our result also generalizes (Zh.
    Mat. Fiz. Anal. Geom. 9 (2013) 536–581, 611, 615) to complex W and to all crossover
    ensembles in between. The main technical inputs are the recent\r\nmultiresolvent
    local laws with traceless deterministic matrices from the companion paper (Comm.
    Math. Phys. 388 (2021) 1005–1048)."
acknowledgement: The second author is partially funded by the ERC Advanced Grant “RMTBEYOND”
  No. 101020331. The third author is supported by Dr. Max Rössler, the Walter Haefner
  Foundation and the ETH Zürich Foundation.
article_processing_charge: No
article_type: original
arxiv: 1
author:
- first_name: Giorgio
  full_name: Cipolloni, Giorgio
  id: 42198EFA-F248-11E8-B48F-1D18A9856A87
  last_name: Cipolloni
  orcid: 0000-0002-4901-7992
- first_name: László
  full_name: Erdös, László
  id: 4DBD5372-F248-11E8-B48F-1D18A9856A87
  last_name: Erdös
  orcid: 0000-0001-5366-9603
- first_name: Dominik J
  full_name: Schröder, Dominik J
  id: 408ED176-F248-11E8-B48F-1D18A9856A87
  last_name: Schröder
  orcid: 0000-0002-2904-1856
citation:
  ama: Cipolloni G, Erdös L, Schröder DJ. Functional central limit theorems for Wigner
    matrices. <i>Annals of Applied Probability</i>. 2023;33(1):447-489. doi:<a href="https://doi.org/10.1214/22-AAP1820">10.1214/22-AAP1820</a>
  apa: Cipolloni, G., Erdös, L., &#38; Schröder, D. J. (2023). Functional central
    limit theorems for Wigner matrices. <i>Annals of Applied Probability</i>. Institute
    of Mathematical Statistics. <a href="https://doi.org/10.1214/22-AAP1820">https://doi.org/10.1214/22-AAP1820</a>
  chicago: Cipolloni, Giorgio, László Erdös, and Dominik J Schröder. “Functional Central
    Limit Theorems for Wigner Matrices.” <i>Annals of Applied Probability</i>. Institute
    of Mathematical Statistics, 2023. <a href="https://doi.org/10.1214/22-AAP1820">https://doi.org/10.1214/22-AAP1820</a>.
  ieee: G. Cipolloni, L. Erdös, and D. J. Schröder, “Functional central limit theorems
    for Wigner matrices,” <i>Annals of Applied Probability</i>, vol. 33, no. 1. Institute
    of Mathematical Statistics, pp. 447–489, 2023.
  ista: Cipolloni G, Erdös L, Schröder DJ. 2023. Functional central limit theorems
    for Wigner matrices. Annals of Applied Probability. 33(1), 447–489.
  mla: Cipolloni, Giorgio, et al. “Functional Central Limit Theorems for Wigner Matrices.”
    <i>Annals of Applied Probability</i>, vol. 33, no. 1, Institute of Mathematical
    Statistics, 2023, pp. 447–89, doi:<a href="https://doi.org/10.1214/22-AAP1820">10.1214/22-AAP1820</a>.
  short: G. Cipolloni, L. Erdös, D.J. Schröder, Annals of Applied Probability 33 (2023)
    447–489.
date_created: 2023-03-26T22:01:08Z
date_published: 2023-02-01T00:00:00Z
date_updated: 2023-10-17T12:48:52Z
day: '01'
department:
- _id: LaEr
doi: 10.1214/22-AAP1820
ec_funded: 1
external_id:
  arxiv:
  - '2012.13218'
  isi:
  - '000946432400015'
intvolume: '        33'
isi: 1
issue: '1'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://arxiv.org/abs/2012.13218
month: '02'
oa: 1
oa_version: Preprint
page: 447-489
project:
- _id: 62796744-2b32-11ec-9570-940b20777f1d
  call_identifier: H2020
  grant_number: '101020331'
  name: Random matrices beyond Wigner-Dyson-Mehta
publication: Annals of Applied Probability
publication_identifier:
  issn:
  - 1050-5164
publication_status: published
publisher: Institute of Mathematical Statistics
quality_controlled: '1'
scopus_import: '1'
status: public
title: Functional central limit theorems for Wigner matrices
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 33
year: '2023'
...
---
_id: '12762'
abstract:
- lang: eng
  text: Neurons in the brain are wired into adaptive networks that exhibit collective
    dynamics as diverse as scale-specific oscillations and scale-free neuronal avalanches.
    Although existing models account for oscillations and avalanches separately, they
    typically do not explain both phenomena, are too complex to analyze analytically
    or intractable to infer from data rigorously. Here we propose a feedback-driven
    Ising-like class of neural networks that captures avalanches and oscillations
    simultaneously and quantitatively. In the simplest yet fully microscopic model
    version, we can analytically compute the phase diagram and make direct contact
    with human brain resting-state activity recordings via tractable inference of
    the model’s two essential parameters. The inferred model quantitatively captures
    the dynamics over a broad range of scales, from single sensor oscillations to
    collective behaviors of extreme events and neuronal avalanches. Importantly, the
    inferred parameters indicate that the co-existence of scale-specific (oscillations)
    and scale-free (avalanches) dynamics occurs close to a non-equilibrium critical
    point at the onset of self-sustained oscillations.
acknowledgement: This research was funded in whole, or in part, by the Austrian Science
  Fund (FWF) (grant no. PT1013M03318 to F.L. and no. P34015 to G.T.). For the purpose
  of open access, the author has applied a CC BY public copyright licence to any Author
  Accepted Manuscript version arising from this submission. The study was supported
  by the European Union Horizon 2020 research and innovation program under the Marie
  Sklodowska-Curie action (grant agreement No. 754411 to F.L.).
article_processing_charge: No
article_type: original
arxiv: 1
author:
- first_name: Fabrizio
  full_name: Lombardi, Fabrizio
  id: A057D288-3E88-11E9-986D-0CF4E5697425
  last_name: Lombardi
  orcid: 0000-0003-2623-5249
- first_name: Selver
  full_name: Pepic, Selver
  id: F93245C4-C3CA-11E9-B4F0-C6F4E5697425
  last_name: Pepic
- first_name: Oren
  full_name: Shriki, Oren
  last_name: Shriki
- first_name: Gašper
  full_name: Tkačik, Gašper
  id: 3D494DCA-F248-11E8-B48F-1D18A9856A87
  last_name: Tkačik
  orcid: 0000-0002-6699-1455
- first_name: Daniele
  full_name: De Martino, Daniele
  id: 3FF5848A-F248-11E8-B48F-1D18A9856A87
  last_name: De Martino
  orcid: 0000-0002-5214-4706
citation:
  ama: Lombardi F, Pepic S, Shriki O, Tkačik G, De Martino D. Statistical modeling
    of adaptive neural networks explains co-existence of avalanches and oscillations
    in resting human brain. <i>Nature Computational Science</i>. 2023;3:254-263. doi:<a
    href="https://doi.org/10.1038/s43588-023-00410-9">10.1038/s43588-023-00410-9</a>
  apa: Lombardi, F., Pepic, S., Shriki, O., Tkačik, G., &#38; De Martino, D. (2023).
    Statistical modeling of adaptive neural networks explains co-existence of avalanches
    and oscillations in resting human brain. <i>Nature Computational Science</i>.
    Springer Nature. <a href="https://doi.org/10.1038/s43588-023-00410-9">https://doi.org/10.1038/s43588-023-00410-9</a>
  chicago: Lombardi, Fabrizio, Selver Pepic, Oren Shriki, Gašper Tkačik, and Daniele
    De Martino. “Statistical Modeling of Adaptive Neural Networks Explains Co-Existence
    of Avalanches and Oscillations in Resting Human Brain.” <i>Nature Computational
    Science</i>. Springer Nature, 2023. <a href="https://doi.org/10.1038/s43588-023-00410-9">https://doi.org/10.1038/s43588-023-00410-9</a>.
  ieee: F. Lombardi, S. Pepic, O. Shriki, G. Tkačik, and D. De Martino, “Statistical
    modeling of adaptive neural networks explains co-existence of avalanches and oscillations
    in resting human brain,” <i>Nature Computational Science</i>, vol. 3. Springer
    Nature, pp. 254–263, 2023.
  ista: Lombardi F, Pepic S, Shriki O, Tkačik G, De Martino D. 2023. Statistical modeling
    of adaptive neural networks explains co-existence of avalanches and oscillations
    in resting human brain. Nature Computational Science. 3, 254–263.
  mla: Lombardi, Fabrizio, et al. “Statistical Modeling of Adaptive Neural Networks
    Explains Co-Existence of Avalanches and Oscillations in Resting Human Brain.”
    <i>Nature Computational Science</i>, vol. 3, Springer Nature, 2023, pp. 254–63,
    doi:<a href="https://doi.org/10.1038/s43588-023-00410-9">10.1038/s43588-023-00410-9</a>.
  short: F. Lombardi, S. Pepic, O. Shriki, G. Tkačik, D. De Martino, Nature Computational
    Science 3 (2023) 254–263.
date_created: 2023-03-26T22:01:08Z
date_published: 2023-03-20T00:00:00Z
date_updated: 2023-08-16T12:41:53Z
day: '20'
ddc:
- '570'
department:
- _id: GaTk
- _id: GradSch
doi: 10.1038/s43588-023-00410-9
ec_funded: 1
external_id:
  arxiv:
  - '2108.06686'
file:
- access_level: open_access
  checksum: 7c63b2b2edfd68aaffe96d70ca6a865a
  content_type: application/pdf
  creator: dernst
  date_created: 2023-08-16T12:39:57Z
  date_updated: 2023-08-16T12:39:57Z
  file_id: '14073'
  file_name: 2023_NatureCompScience_Lombardi.pdf
  file_size: 4474284
  relation: main_file
  success: 1
file_date_updated: 2023-08-16T12:39:57Z
has_accepted_license: '1'
intvolume: '         3'
language:
- iso: eng
month: '03'
oa: 1
oa_version: Published Version
page: 254-263
project:
- _id: 260C2330-B435-11E9-9278-68D0E5697425
  call_identifier: H2020
  grant_number: '754411'
  name: ISTplus - Postdoctoral Fellowships
- _id: eb943429-77a9-11ec-83b8-9f471cdf5c67
  grant_number: M03318
  name: Functional Advantages of Critical Brain Dynamics
- _id: 626c45b5-2b32-11ec-9570-e509828c1ba6
  grant_number: P34015
  name: Efficient coding with biophysical realism
publication: Nature Computational Science
publication_identifier:
  eissn:
  - 2662-8457
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
scopus_import: '1'
status: public
title: Statistical modeling of adaptive neural networks explains co-existence of avalanches
  and oscillations in resting human brain
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 3
year: '2023'
...
---
_id: '12763'
abstract:
- lang: eng
  text: 'Kleinjohann (Archiv der Mathematik 35(1):574–582, 1980; Mathematische Zeitschrift
    176(3), 327–344, 1981) and Bangert (Archiv der Mathematik 38(1):54–57, 1982) extended
    the reach rch(S) from subsets S of Euclidean space to the reach rchM(S) of subsets
    S of Riemannian manifolds M, where M is smooth (we’ll assume at least C3). Bangert
    showed that sets of positive reach in Euclidean space and Riemannian manifolds
    are very similar. In this paper we introduce a slight variant of Kleinjohann’s
    and Bangert’s extension and quantify the similarity between sets of positive reach
    in Euclidean space and Riemannian manifolds in a new way: Given p∈M and q∈S, we
    bound the local feature size (a local version of the reach) of its lifting to
    the tangent space via the inverse exponential map (exp−1p(S)) at q, assuming that
    rchM(S) and the geodesic distance dM(p,q) are bounded. These bounds are motivated
    by the importance of the reach and local feature size to manifold learning, topological
    inference, and triangulating manifolds and the fact that intrinsic approaches
    circumvent the curse of dimensionality.'
acknowledgement: "We thank Eddie Aamari, David Cohen-Steiner, Isa Costantini, Fred
  Chazal, Ramsay Dyer, André Lieutier, and Alef Sterk for discussion and Pierre Pansu
  for encouragement. We further acknowledge the anonymous reviewers whose comments
  helped improve the exposition.\r\nThe research leading to these results has received
  funding from the European Research Council (ERC) under the European Union’s Seventh
  Framework Programme (FP/2007-2013) / ERC Grant Agreement No. 339025 GUDHI (Algorithmic
  Foundations of Geometry Understanding in Higher Dimensions). The first author is
  further supported by the French government, through the 3IA Côte d’Azur Investments
  in the Future project managed by the National Research Agency (ANR) with the reference
  number ANR-19-P3IA-0002. The second author is supported by the European Union’s
  Horizon 2020 research and innovation programme under the Marie Skłodowska-Curie
  Grant Agreement No. 754411 and the Austrian science fund (FWF) M-3073."
article_processing_charge: No
article_type: original
author:
- first_name: Jean Daniel
  full_name: Boissonnat, Jean Daniel
  last_name: Boissonnat
- first_name: Mathijs
  full_name: Wintraecken, Mathijs
  id: 307CFBC8-F248-11E8-B48F-1D18A9856A87
  last_name: Wintraecken
  orcid: 0000-0002-7472-2220
citation:
  ama: Boissonnat JD, Wintraecken M. The reach of subsets of manifolds. <i>Journal
    of Applied and Computational Topology</i>. 2023;7:619-641. doi:<a href="https://doi.org/10.1007/s41468-023-00116-x">10.1007/s41468-023-00116-x</a>
  apa: Boissonnat, J. D., &#38; Wintraecken, M. (2023). The reach of subsets of manifolds.
    <i>Journal of Applied and Computational Topology</i>. Springer Nature. <a href="https://doi.org/10.1007/s41468-023-00116-x">https://doi.org/10.1007/s41468-023-00116-x</a>
  chicago: Boissonnat, Jean Daniel, and Mathijs Wintraecken. “The Reach of Subsets
    of Manifolds.” <i>Journal of Applied and Computational Topology</i>. Springer
    Nature, 2023. <a href="https://doi.org/10.1007/s41468-023-00116-x">https://doi.org/10.1007/s41468-023-00116-x</a>.
  ieee: J. D. Boissonnat and M. Wintraecken, “The reach of subsets of manifolds,”
    <i>Journal of Applied and Computational Topology</i>, vol. 7. Springer Nature,
    pp. 619–641, 2023.
  ista: Boissonnat JD, Wintraecken M. 2023. The reach of subsets of manifolds. Journal
    of Applied and Computational Topology. 7, 619–641.
  mla: Boissonnat, Jean Daniel, and Mathijs Wintraecken. “The Reach of Subsets of
    Manifolds.” <i>Journal of Applied and Computational Topology</i>, vol. 7, Springer
    Nature, 2023, pp. 619–41, doi:<a href="https://doi.org/10.1007/s41468-023-00116-x">10.1007/s41468-023-00116-x</a>.
  short: J.D. Boissonnat, M. Wintraecken, Journal of Applied and Computational Topology
    7 (2023) 619–641.
date_created: 2023-03-26T22:01:08Z
date_published: 2023-09-01T00:00:00Z
date_updated: 2023-10-04T12:07:18Z
day: '01'
department:
- _id: HeEd
doi: 10.1007/s41468-023-00116-x
ec_funded: 1
intvolume: '         7'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://inserm.hal.science/INRIA-SACLAY/hal-04083524v1
month: '09'
oa: 1
oa_version: Submitted Version
page: 619-641
project:
- _id: 260C2330-B435-11E9-9278-68D0E5697425
  call_identifier: H2020
  grant_number: '754411'
  name: ISTplus - Postdoctoral Fellowships
- _id: fc390959-9c52-11eb-aca3-afa58bd282b2
  grant_number: M03073
  name: Learning and triangulating manifolds via collapses
publication: Journal of Applied and Computational Topology
publication_identifier:
  eissn:
  - 2367-1734
  issn:
  - 2367-1726
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
scopus_import: '1'
status: public
title: The reach of subsets of manifolds
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 7
year: '2023'
...
---
_id: '12764'
abstract:
- lang: eng
  text: We study a new discretization of the Gaussian curvature for polyhedral surfaces.
    This discrete Gaussian curvature is defined on each conical singularity of a polyhedral
    surface as the quotient of the angle defect and the area of the Voronoi cell corresponding
    to the singularity. We divide polyhedral surfaces into discrete conformal classes
    using a generalization of discrete conformal equivalence pioneered by Feng Luo.
    We subsequently show that, in every discrete conformal class, there exists a polyhedral
    surface with constant discrete Gaussian curvature. We also provide explicit examples
    to demonstrate that this surface is in general not unique.
acknowledgement: Open access funding provided by the Austrian Science Fund (FWF).
  This research was supported by the FWF grant, Project number I4245-N35, and by the
  Deutsche Forschungsgemeinschaft (DFG - German Research Foundation) - Project-ID
  195170736 - TRR109.
article_processing_charge: Yes (via OA deal)
article_type: original
author:
- first_name: Hana
  full_name: Kourimska, Hana
  id: D9B8E14C-3C26-11EA-98F5-1F833DDC885E
  last_name: Kourimska
  orcid: 0000-0001-7841-0091
citation:
  ama: Kourimska H. Discrete yamabe problem for polyhedral surfaces. <i>Discrete and
    Computational Geometry</i>. 2023;70:123-153. doi:<a href="https://doi.org/10.1007/s00454-023-00484-2">10.1007/s00454-023-00484-2</a>
  apa: Kourimska, H. (2023). Discrete yamabe problem for polyhedral surfaces. <i>Discrete
    and Computational Geometry</i>. Springer Nature. <a href="https://doi.org/10.1007/s00454-023-00484-2">https://doi.org/10.1007/s00454-023-00484-2</a>
  chicago: Kourimska, Hana. “Discrete Yamabe Problem for Polyhedral Surfaces.” <i>Discrete
    and Computational Geometry</i>. Springer Nature, 2023. <a href="https://doi.org/10.1007/s00454-023-00484-2">https://doi.org/10.1007/s00454-023-00484-2</a>.
  ieee: H. Kourimska, “Discrete yamabe problem for polyhedral surfaces,” <i>Discrete
    and Computational Geometry</i>, vol. 70. Springer Nature, pp. 123–153, 2023.
  ista: Kourimska H. 2023. Discrete yamabe problem for polyhedral surfaces. Discrete
    and Computational Geometry. 70, 123–153.
  mla: Kourimska, Hana. “Discrete Yamabe Problem for Polyhedral Surfaces.” <i>Discrete
    and Computational Geometry</i>, vol. 70, Springer Nature, 2023, pp. 123–53, doi:<a
    href="https://doi.org/10.1007/s00454-023-00484-2">10.1007/s00454-023-00484-2</a>.
  short: H. Kourimska, Discrete and Computational Geometry 70 (2023) 123–153.
date_created: 2023-03-26T22:01:09Z
date_published: 2023-07-01T00:00:00Z
date_updated: 2023-10-04T11:46:48Z
day: '01'
ddc:
- '510'
department:
- _id: HeEd
doi: 10.1007/s00454-023-00484-2
external_id:
  isi:
  - '000948148000001'
file:
- access_level: open_access
  checksum: cdbf90ba4a7ddcb190d37b9e9d4cb9d3
  content_type: application/pdf
  creator: dernst
  date_created: 2023-10-04T11:46:24Z
  date_updated: 2023-10-04T11:46:24Z
  file_id: '14396'
  file_name: 2023_DiscreteGeometry_Kourimska.pdf
  file_size: 1026683
  relation: main_file
  success: 1
file_date_updated: 2023-10-04T11:46:24Z
has_accepted_license: '1'
intvolume: '        70'
isi: 1
language:
- iso: eng
month: '07'
oa: 1
oa_version: Published Version
page: 123-153
project:
- _id: 26AD5D90-B435-11E9-9278-68D0E5697425
  call_identifier: FWF
  grant_number: I04245
  name: Algebraic Footprints of Geometric Features in Homology
publication: Discrete and Computational Geometry
publication_identifier:
  eissn:
  - 1432-0444
  issn:
  - 0179-5376
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
scopus_import: '1'
status: public
title: Discrete yamabe problem for polyhedral surfaces
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 70
year: '2023'
...
---
_id: '12765'
abstract:
- lang: eng
  text: "Animals exhibit a variety of behavioural defences against socially transmitted
    parasites. These defences evolved to increase host fitness by avoiding, resisting
    or tolerating infection.\r\nBecause they can occur in both infected individuals
    and their uninfected social partners, these defences often have important consequences
    for the social group.\r\nHere, we discuss the evolution and ecology of anti-parasite
    behavioural defences across a taxonomically wide social spectrum, considering
    colonial groups, stable groups, transitional groups and solitary animals.\r\nWe
    discuss avoidance, resistance and tolerance behaviours across these social group
    structures, identifying how social complexity, group composition and interdependent
    social relationships may contribute to the expression and evolution of behavioural
    strategies.\r\nFinally, we outline avenues for further investigation such as approaches
    to quantify group-level responses, and the connection of the physiological and
    behavioural response to parasites in different social contexts."
article_processing_charge: No
article_type: review
author:
- first_name: Sebastian
  full_name: Stockmaier, Sebastian
  last_name: Stockmaier
- first_name: Yuko
  full_name: Ulrich, Yuko
  last_name: Ulrich
- first_name: Gregory F.
  full_name: Albery, Gregory F.
  last_name: Albery
- first_name: Sylvia
  full_name: Cremer, Sylvia
  id: 2F64EC8C-F248-11E8-B48F-1D18A9856A87
  last_name: Cremer
  orcid: 0000-0002-2193-3868
- first_name: Patricia C.
  full_name: Lopes, Patricia C.
  last_name: Lopes
citation:
  ama: Stockmaier S, Ulrich Y, Albery GF, Cremer S, Lopes PC. Behavioural defences
    against parasites across host social structures. <i>Functional Ecology</i>. 2023;37(4):809-820.
    doi:<a href="https://doi.org/10.1111/1365-2435.14310">10.1111/1365-2435.14310</a>
  apa: Stockmaier, S., Ulrich, Y., Albery, G. F., Cremer, S., &#38; Lopes, P. C. (2023).
    Behavioural defences against parasites across host social structures. <i>Functional
    Ecology</i>. British Ecological Society. <a href="https://doi.org/10.1111/1365-2435.14310">https://doi.org/10.1111/1365-2435.14310</a>
  chicago: Stockmaier, Sebastian, Yuko Ulrich, Gregory F. Albery, Sylvia Cremer, and
    Patricia C. Lopes. “Behavioural Defences against Parasites across Host Social
    Structures.” <i>Functional Ecology</i>. British Ecological Society, 2023. <a href="https://doi.org/10.1111/1365-2435.14310">https://doi.org/10.1111/1365-2435.14310</a>.
  ieee: S. Stockmaier, Y. Ulrich, G. F. Albery, S. Cremer, and P. C. Lopes, “Behavioural
    defences against parasites across host social structures,” <i>Functional Ecology</i>,
    vol. 37, no. 4. British Ecological Society, pp. 809–820, 2023.
  ista: Stockmaier S, Ulrich Y, Albery GF, Cremer S, Lopes PC. 2023. Behavioural defences
    against parasites across host social structures. Functional Ecology. 37(4), 809–820.
  mla: Stockmaier, Sebastian, et al. “Behavioural Defences against Parasites across
    Host Social Structures.” <i>Functional Ecology</i>, vol. 37, no. 4, British Ecological
    Society, 2023, pp. 809–20, doi:<a href="https://doi.org/10.1111/1365-2435.14310">10.1111/1365-2435.14310</a>.
  short: S. Stockmaier, Y. Ulrich, G.F. Albery, S. Cremer, P.C. Lopes, Functional
    Ecology 37 (2023) 809–820.
date_created: 2023-03-26T22:01:09Z
date_published: 2023-04-01T00:00:00Z
date_updated: 2023-10-04T11:50:15Z
day: '01'
department:
- _id: SyCr
doi: 10.1111/1365-2435.14310
external_id:
  isi:
  - '000948940500001'
intvolume: '        37'
isi: 1
issue: '4'
language:
- iso: eng
month: '04'
oa_version: None
page: 809-820
publication: Functional Ecology
publication_identifier:
  eissn:
  - 1365-2435
  issn:
  - 0269-8463
publication_status: published
publisher: British Ecological Society
quality_controlled: '1'
scopus_import: '1'
status: public
title: Behavioural defences against parasites across host social structures
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 37
year: '2023'
...
---
_id: '12781'
abstract:
- lang: eng
  text: "Most energy in humans is produced in form of ATP by the mitochondrial respiratory
    chain consisting of several protein assemblies embedded into lipid membrane (complexes
    I-V). Complex I is the first and the largest enzyme of the respiratory chain which
    is essential for energy production. It couples the transfer of two electrons from
    NADH to ubiquinone with proton translocation across bacterial or inner mitochondrial
    membrane. The coupling mechanism between electron transfer and proton translocation
    is one of the biggest enigma in bioenergetics and structural biology. Even though
    the enzyme has been studied for decades, only recent technological advances in
    cryo-EM allowed its extensive structural investigation. \r\n\r\nComplex I from
    E.coli appears to be of special importance because it is a perfect model system
    with a rich mutant library, however the structure of the entire complex was unknown.
    In this thesis I have resolved structures of the minimal complex I version from
    E. coli in different states including reduced, inhibited, under reaction turnover
    and several others. Extensive structural analyses of these structures and comparison
    to structures from other species allowed to derive general features of conformational
    dynamics and propose a universal coupling mechanism. The mechanism is straightforward,
    robust and consistent with decades of experimental data available for complex
    I from different species. \r\n\r\nCyanobacterial NDH (cyanobacterial complex I)
    is a part of broad complex I superfamily and was studied as well in this thesis.
    It plays an important role in cyclic electron transfer (CET), during which electrons
    are cycled within PSI through ferredoxin and plastoquinone to generate proton
    gradient without NADPH production. Here, I solved structure of NDH and revealed
    additional state, which was not observed before. The novel “resting” state allowed
    to propose the mechanism of CET regulation. Moreover, conformational dynamics
    of NDH resembles one in complex I which suggest more broad universality of the
    proposed coupling mechanism.\r\n\r\nIn summary, results presented here helped
    to interpret decades of experimental data for complex I and contributed to fundamental
    mechanistic understanding of protein function.\r\n"
acknowledged_ssus:
- _id: EM-Fac
alternative_title:
- ISTA Thesis
article_processing_charge: No
author:
- first_name: Vladyslav
  full_name: Kravchuk, Vladyslav
  id: 4D62F2A6-F248-11E8-B48F-1D18A9856A87
  last_name: Kravchuk
citation:
  ama: Kravchuk V. Structural and mechanistic study of bacterial complex I and its
    cyanobacterial ortholog. 2023. doi:<a href="https://doi.org/10.15479/at:ista:12781">10.15479/at:ista:12781</a>
  apa: Kravchuk, V. (2023). <i>Structural and mechanistic study of bacterial complex
    I and its cyanobacterial ortholog</i>. Institute of Science and Technology Austria.
    <a href="https://doi.org/10.15479/at:ista:12781">https://doi.org/10.15479/at:ista:12781</a>
  chicago: Kravchuk, Vladyslav. “Structural and Mechanistic Study of Bacterial Complex
    I and Its Cyanobacterial Ortholog.” Institute of Science and Technology Austria,
    2023. <a href="https://doi.org/10.15479/at:ista:12781">https://doi.org/10.15479/at:ista:12781</a>.
  ieee: V. Kravchuk, “Structural and mechanistic study of bacterial complex I and
    its cyanobacterial ortholog,” Institute of Science and Technology Austria, 2023.
  ista: Kravchuk V. 2023. Structural and mechanistic study of bacterial complex I
    and its cyanobacterial ortholog. Institute of Science and Technology Austria.
  mla: Kravchuk, Vladyslav. <i>Structural and Mechanistic Study of Bacterial Complex
    I and Its Cyanobacterial Ortholog</i>. Institute of Science and Technology Austria,
    2023, doi:<a href="https://doi.org/10.15479/at:ista:12781">10.15479/at:ista:12781</a>.
  short: V. Kravchuk, Structural and Mechanistic Study of Bacterial Complex I and
    Its Cyanobacterial Ortholog, Institute of Science and Technology Austria, 2023.
date_created: 2023-03-31T12:24:42Z
date_published: 2023-03-23T00:00:00Z
date_updated: 2023-08-04T08:54:51Z
day: '23'
ddc:
- '570'
- '572'
degree_awarded: PhD
department:
- _id: GradSch
- _id: LeSa
doi: 10.15479/at:ista:12781
ec_funded: 1
file:
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  creator: vkravchu
  date_created: 2023-04-19T14:33:41Z
  date_updated: 2023-04-19T14:33:41Z
  embargo: 2024-04-20
  embargo_to: local
  file_id: '12852'
  file_name: VladyslavKravchuk_PhD_Thesis_PostSub_Final_1.pdf
  file_size: 6071553
  relation: main_file
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  checksum: c12055c48411d030d2afa51de2166221
  content_type: application/vnd.openxmlformats-officedocument.wordprocessingml.document
  creator: vkravchu
  date_created: 2023-04-19T14:33:52Z
  date_updated: 2023-04-20T07:02:59Z
  embargo: 2024-04-20
  embargo_to: local
  file_id: '12853'
  file_name: VladyslavKravchuk_PhD_Thesis_PostSub_Final.docx
  file_size: 19468766
  relation: source_file
file_date_updated: 2023-04-20T07:02:59Z
has_accepted_license: '1'
language:
- iso: eng
month: '03'
oa_version: Published Version
page: '127'
project:
- _id: 238A0A5A-32DE-11EA-91FC-C7463DDC885E
  grant_number: '25541'
  name: 'Structural characterization of E. coli complex I: an important mechanistic
    model'
- _id: 627abdeb-2b32-11ec-9570-ec31a97243d3
  call_identifier: H2020
  grant_number: '101020697'
  name: Structure and mechanism of respiratory chain molecular machines
publication_identifier:
  isbn:
  - 978-3-99078-029-9
  issn:
  - 2663-337X
publication_status: published
publisher: Institute of Science and Technology Austria
related_material:
  record:
  - id: '12138'
    relation: part_of_dissertation
    status: public
status: public
supervisor:
- first_name: Leonid A
  full_name: Sazanov, Leonid A
  id: 338D39FE-F248-11E8-B48F-1D18A9856A87
  last_name: Sazanov
  orcid: 0000-0002-0977-7989
title: Structural and mechanistic study of bacterial complex I and its cyanobacterial
  ortholog
type: dissertation
user_id: 8b945eb4-e2f2-11eb-945a-df72226e66a9
year: '2023'
...
---
_id: '12786'
abstract:
- lang: eng
  text: AMPA glutamate receptors (AMPARs) mediate excitatory neurotransmission throughout
    the brain. Their signalling is uniquely diversified by brain region-specific auxiliary
    subunits, providing an opportunity for the development of selective therapeutics.
    AMPARs associated with TARP γ8 are enriched in the hippocampus, and are targets
    of emerging anti-epileptic drugs. To understand their therapeutic activity, we
    determined cryo-EM structures of the GluA1/2-γ8 receptor associated with three
    potent, chemically diverse ligands. We find that despite sharing a lipid-exposed
    and water-accessible binding pocket, drug action is differentially affected by
    binding-site mutants. Together with patch-clamp recordings and MD simulations
    we also demonstrate that ligand-triggered reorganisation of the AMPAR-TARP interface
    contributes to modulation. Unexpectedly, one ligand (JNJ-61432059) acts bifunctionally,
    negatively affecting GluA1 but exerting positive modulatory action on GluA2-containing
    AMPARs, in a TARP stoichiometry-dependent manner. These results further illuminate
    the action of TARPs, demonstrate the sensitive balance between positive and negative
    modulatory action, and provide a mechanistic platform for development of both
    positive and negative selective AMPAR modulators.
acknowledgement: We thank James Krieger for generating the ‘proDy’ interaction maps
  in Fig. 5B and S7C, and Jan-Niklas Dohrke for critically reading the manuscript.
  We thank members of the Greger lab for insightful comments during this study. We
  acknowledge Trevor Rutherford for confirming ligand integrity by NMR. We are also
  grateful to LMB scientific computing and the EM facility for their support. This
  research was funded in part by the Wellcome Trust (223194/Z/21/Z) to I.H.G. For
  the purpose of Open Access, the MRC Laboratory of Molecular Biology has applied
  a CC BY public copyright licence to any Author Accepted Manuscript (AAM) version
  arising from this submission. Further funding came from the Medical Research Council
  (MRU105174197) to I.H.G, and NIH grant (R56/R01MH123474) to T.N.
article_number: '1659'
article_processing_charge: No
article_type: original
author:
- first_name: Danyang
  full_name: Zhang, Danyang
  last_name: Zhang
- first_name: Remigijus
  full_name: Lape, Remigijus
  last_name: Lape
- first_name: Saher A.
  full_name: Shaikh, Saher A.
  last_name: Shaikh
- first_name: Bianka K.
  full_name: Kohegyi, Bianka K.
  last_name: Kohegyi
- first_name: Jake
  full_name: Watson, Jake
  id: 63836096-4690-11EA-BD4E-32803DDC885E
  last_name: Watson
  orcid: 0000-0002-8698-3823
- first_name: Ondrej
  full_name: Cais, Ondrej
  last_name: Cais
- first_name: Terunaga
  full_name: Nakagawa, Terunaga
  last_name: Nakagawa
- first_name: Ingo H.
  full_name: Greger, Ingo H.
  last_name: Greger
citation:
  ama: Zhang D, Lape R, Shaikh SA, et al. Modulatory mechanisms of TARP γ8-selective
    AMPA receptor therapeutics. <i>Nature Communications</i>. 2023;14. doi:<a href="https://doi.org/10.1038/s41467-023-37259-5">10.1038/s41467-023-37259-5</a>
  apa: Zhang, D., Lape, R., Shaikh, S. A., Kohegyi, B. K., Watson, J., Cais, O., …
    Greger, I. H. (2023). Modulatory mechanisms of TARP γ8-selective AMPA receptor
    therapeutics. <i>Nature Communications</i>. Springer Nature. <a href="https://doi.org/10.1038/s41467-023-37259-5">https://doi.org/10.1038/s41467-023-37259-5</a>
  chicago: Zhang, Danyang, Remigijus Lape, Saher A. Shaikh, Bianka K. Kohegyi, Jake
    Watson, Ondrej Cais, Terunaga Nakagawa, and Ingo H. Greger. “Modulatory Mechanisms
    of TARP Γ8-Selective AMPA Receptor Therapeutics.” <i>Nature Communications</i>.
    Springer Nature, 2023. <a href="https://doi.org/10.1038/s41467-023-37259-5">https://doi.org/10.1038/s41467-023-37259-5</a>.
  ieee: D. Zhang <i>et al.</i>, “Modulatory mechanisms of TARP γ8-selective AMPA receptor
    therapeutics,” <i>Nature Communications</i>, vol. 14. Springer Nature, 2023.
  ista: Zhang D, Lape R, Shaikh SA, Kohegyi BK, Watson J, Cais O, Nakagawa T, Greger
    IH. 2023. Modulatory mechanisms of TARP γ8-selective AMPA receptor therapeutics.
    Nature Communications. 14, 1659.
  mla: Zhang, Danyang, et al. “Modulatory Mechanisms of TARP Γ8-Selective AMPA Receptor
    Therapeutics.” <i>Nature Communications</i>, vol. 14, 1659, Springer Nature, 2023,
    doi:<a href="https://doi.org/10.1038/s41467-023-37259-5">10.1038/s41467-023-37259-5</a>.
  short: D. Zhang, R. Lape, S.A. Shaikh, B.K. Kohegyi, J. Watson, O. Cais, T. Nakagawa,
    I.H. Greger, Nature Communications 14 (2023).
date_created: 2023-04-02T22:01:09Z
date_published: 2023-03-25T00:00:00Z
date_updated: 2023-12-13T11:15:58Z
day: '25'
ddc:
- '570'
department:
- _id: PeJo
doi: 10.1038/s41467-023-37259-5
external_id:
  isi:
  - '001066658700003'
file:
- access_level: open_access
  checksum: 0a97b31191432dae5853bbb5ccb7698d
  content_type: application/pdf
  creator: dernst
  date_created: 2023-04-03T06:38:56Z
  date_updated: 2023-04-03T06:38:56Z
  file_id: '12797'
  file_name: 2023_NatureComm_Zhang.pdf
  file_size: 2613996
  relation: main_file
  success: 1
file_date_updated: 2023-04-03T06:38:56Z
has_accepted_license: '1'
intvolume: '        14'
isi: 1
language:
- iso: eng
month: '03'
oa: 1
oa_version: Published Version
publication: Nature Communications
publication_identifier:
  eissn:
  - 2041-1723
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
scopus_import: '1'
status: public
title: Modulatory mechanisms of TARP γ8-selective AMPA receptor therapeutics
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 14
year: '2023'
...
---
_id: '12787'
abstract:
- lang: eng
  text: "Populations evolve in spatially heterogeneous environments. While a certain
    trait might bring a fitness advantage in some patch of the environment, a different
    trait might be advantageous in another patch. Here, we study the Moran birth–death
    process with two types of individuals in a population stretched across two patches
    of size N, each patch favouring one of the two types. We show that the long-term
    fate of such populations crucially depends on the migration rate μ\r\n between
    the patches. To classify the possible fates, we use the distinction between polynomial
    (short) and exponential (long) timescales. We show that when μ is high then one
    of the two types fixates on the whole population after a number of steps that
    is only polynomial in N. By contrast, when μ is low then each type holds majority
    in the patch where it is favoured for a number of steps that is at least exponential
    in N. Moreover, we precisely identify the threshold migration rate μ⋆ that separates
    those two scenarios, thereby exactly delineating the situations that support long-term
    coexistence of the two types. We also discuss the case of various cycle graphs
    and we present computer simulations that perfectly match our analytical results."
acknowledgement: J.S. and K.C. acknowledge support from the ERC CoG 863818 (ForM-SMArt)
article_number: '20220685'
article_processing_charge: No
article_type: original
author:
- first_name: Jakub
  full_name: Svoboda, Jakub
  id: 130759D2-D7DD-11E9-87D2-DE0DE6697425
  last_name: Svoboda
  orcid: 0000-0002-1419-3267
- first_name: Josef
  full_name: Tkadlec, Josef
  id: 3F24CCC8-F248-11E8-B48F-1D18A9856A87
  last_name: Tkadlec
  orcid: 0000-0002-1097-9684
- first_name: Kamran
  full_name: Kaveh, Kamran
  last_name: Kaveh
- first_name: Krishnendu
  full_name: Chatterjee, Krishnendu
  id: 2E5DCA20-F248-11E8-B48F-1D18A9856A87
  last_name: Chatterjee
  orcid: 0000-0002-4561-241X
citation:
  ama: 'Svoboda J, Tkadlec J, Kaveh K, Chatterjee K. Coexistence times in the Moran
    process with environmental heterogeneity. <i>Proceedings of the Royal Society
    A: Mathematical, Physical and Engineering Sciences</i>. 2023;479(2271). doi:<a
    href="https://doi.org/10.1098/rspa.2022.0685">10.1098/rspa.2022.0685</a>'
  apa: 'Svoboda, J., Tkadlec, J., Kaveh, K., &#38; Chatterjee, K. (2023). Coexistence
    times in the Moran process with environmental heterogeneity. <i>Proceedings of
    the Royal Society A: Mathematical, Physical and Engineering Sciences</i>. The
    Royal Society. <a href="https://doi.org/10.1098/rspa.2022.0685">https://doi.org/10.1098/rspa.2022.0685</a>'
  chicago: 'Svoboda, Jakub, Josef Tkadlec, Kamran Kaveh, and Krishnendu Chatterjee.
    “Coexistence Times in the Moran Process with Environmental Heterogeneity.” <i>Proceedings
    of the Royal Society A: Mathematical, Physical and Engineering Sciences</i>. The
    Royal Society, 2023. <a href="https://doi.org/10.1098/rspa.2022.0685">https://doi.org/10.1098/rspa.2022.0685</a>.'
  ieee: 'J. Svoboda, J. Tkadlec, K. Kaveh, and K. Chatterjee, “Coexistence times in
    the Moran process with environmental heterogeneity,” <i>Proceedings of the Royal
    Society A: Mathematical, Physical and Engineering Sciences</i>, vol. 479, no.
    2271. The Royal Society, 2023.'
  ista: 'Svoboda J, Tkadlec J, Kaveh K, Chatterjee K. 2023. Coexistence times in the
    Moran process with environmental heterogeneity. Proceedings of the Royal Society
    A: Mathematical, Physical and Engineering Sciences. 479(2271), 20220685.'
  mla: 'Svoboda, Jakub, et al. “Coexistence Times in the Moran Process with Environmental
    Heterogeneity.” <i>Proceedings of the Royal Society A: Mathematical, Physical
    and Engineering Sciences</i>, vol. 479, no. 2271, 20220685, The Royal Society,
    2023, doi:<a href="https://doi.org/10.1098/rspa.2022.0685">10.1098/rspa.2022.0685</a>.'
  short: 'J. Svoboda, J. Tkadlec, K. Kaveh, K. Chatterjee, Proceedings of the Royal
    Society A: Mathematical, Physical and Engineering Sciences 479 (2023).'
date_created: 2023-04-02T22:01:09Z
date_published: 2023-03-29T00:00:00Z
date_updated: 2025-07-14T09:09:51Z
day: '29'
ddc:
- '000'
department:
- _id: KrCh
doi: 10.1098/rspa.2022.0685
ec_funded: 1
external_id:
  isi:
  - '000957125500002'
file:
- access_level: open_access
  checksum: 13953d349fbefcb5d21ccc6b303297eb
  content_type: application/pdf
  creator: dernst
  date_created: 2023-04-03T06:25:29Z
  date_updated: 2023-04-03T06:25:29Z
  file_id: '12796'
  file_name: 2023_ProceedingsRoyalSocietyA_Svoboda.pdf
  file_size: 827784
  relation: main_file
  success: 1
file_date_updated: 2023-04-03T06:25:29Z
has_accepted_license: '1'
intvolume: '       479'
isi: 1
issue: '2271'
language:
- iso: eng
month: '03'
oa: 1
oa_version: Published Version
project:
- _id: 0599E47C-7A3F-11EA-A408-12923DDC885E
  call_identifier: H2020
  grant_number: '863818'
  name: 'Formal Methods for Stochastic Models: Algorithms and Applications'
publication: 'Proceedings of the Royal Society A: Mathematical, Physical and Engineering
  Sciences'
publication_identifier:
  eissn:
  - 1471-2946
  issn:
  - 1364-5021
publication_status: published
publisher: The Royal Society
quality_controlled: '1'
related_material:
  link:
  - relation: research_data
    url: https://doi.org/10.6084/m9.figshare.21261771.v1
scopus_import: '1'
status: public
title: Coexistence times in the Moran process with environmental heterogeneity
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 479
year: '2023'
...
---
_id: '12788'
abstract:
- lang: eng
  text: We show that the simplest of existing molecules—closed-shell diatomics not
    interacting with one another—host topological charges when driven by periodic
    far-off-resonant laser pulses. A periodically kicked molecular rotor can be mapped
    onto a “crystalline” lattice in angular momentum space. This allows us to define
    quasimomenta and the band structure in the Floquet representation, by analogy
    with the Bloch waves of solid-state physics. Applying laser pulses spaced by 1/3
    of the molecular rotational period creates a lattice with three atoms per unit
    cell with staggered hopping. Within the synthetic dimension of the laser strength,
    we discover Dirac cones with topological charges. These Dirac cones, topologically
    protected by reflection and time-reversal symmetry, are reminiscent of (although
    not equivalent to) that seen in graphene. They—and the corresponding edge states—are
    broadly tunable by adjusting the laser strength and can be observed in present-day
    experiments by measuring molecular alignment and populations of rotational levels.
    This paves the way to study controllable topological physics in gas-phase experiments
    with small molecules as well as to classify dynamical molecular states by their
    topological invariants.
acknowledgement: M. L. acknowledges support by the European Research Council (ERC)
  Starting Grant No. 801770 (ANGULON).
article_number: '103202'
article_processing_charge: No
article_type: original
arxiv: 1
author:
- first_name: Volker
  full_name: Karle, Volker
  id: D7C012AE-D7ED-11E9-95E8-1EC5E5697425
  last_name: Karle
- first_name: Areg
  full_name: Ghazaryan, Areg
  id: 4AF46FD6-F248-11E8-B48F-1D18A9856A87
  last_name: Ghazaryan
  orcid: 0000-0001-9666-3543
- first_name: Mikhail
  full_name: Lemeshko, Mikhail
  id: 37CB05FA-F248-11E8-B48F-1D18A9856A87
  last_name: Lemeshko
  orcid: 0000-0002-6990-7802
citation:
  ama: Karle V, Ghazaryan A, Lemeshko M. Topological charges of periodically kicked
    molecules. <i>Physical Review Letters</i>. 2023;130(10). doi:<a href="https://doi.org/10.1103/PhysRevLett.130.103202">10.1103/PhysRevLett.130.103202</a>
  apa: Karle, V., Ghazaryan, A., &#38; Lemeshko, M. (2023). Topological charges of
    periodically kicked molecules. <i>Physical Review Letters</i>. American Physical
    Society. <a href="https://doi.org/10.1103/PhysRevLett.130.103202">https://doi.org/10.1103/PhysRevLett.130.103202</a>
  chicago: Karle, Volker, Areg Ghazaryan, and Mikhail Lemeshko. “Topological Charges
    of Periodically Kicked Molecules.” <i>Physical Review Letters</i>. American Physical
    Society, 2023. <a href="https://doi.org/10.1103/PhysRevLett.130.103202">https://doi.org/10.1103/PhysRevLett.130.103202</a>.
  ieee: V. Karle, A. Ghazaryan, and M. Lemeshko, “Topological charges of periodically
    kicked molecules,” <i>Physical Review Letters</i>, vol. 130, no. 10. American
    Physical Society, 2023.
  ista: Karle V, Ghazaryan A, Lemeshko M. 2023. Topological charges of periodically
    kicked molecules. Physical Review Letters. 130(10), 103202.
  mla: Karle, Volker, et al. “Topological Charges of Periodically Kicked Molecules.”
    <i>Physical Review Letters</i>, vol. 130, no. 10, 103202, American Physical Society,
    2023, doi:<a href="https://doi.org/10.1103/PhysRevLett.130.103202">10.1103/PhysRevLett.130.103202</a>.
  short: V. Karle, A. Ghazaryan, M. Lemeshko, Physical Review Letters 130 (2023).
date_created: 2023-04-02T22:01:10Z
date_published: 2023-03-10T00:00:00Z
date_updated: 2023-08-01T14:02:06Z
day: '10'
department:
- _id: MiLe
doi: 10.1103/PhysRevLett.130.103202
ec_funded: 1
external_id:
  arxiv:
  - '2206.07067'
  isi:
  - '000957635500003'
intvolume: '       130'
isi: 1
issue: '10'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://doi.org/10.48550/arXiv.2206.07067
month: '03'
oa: 1
oa_version: Preprint
project:
- _id: 2688CF98-B435-11E9-9278-68D0E5697425
  call_identifier: H2020
  grant_number: '801770'
  name: 'Angulon: physics and applications of a new quasiparticle'
publication: Physical Review Letters
publication_identifier:
  eissn:
  - 1079-7114
  issn:
  - 0031-9007
publication_status: published
publisher: American Physical Society
quality_controlled: '1'
related_material:
  link:
  - description: News on the ISTA website
    relation: press_release
    url: https://ista.ac.at/en/news/topology-of-rotating-molecules/
scopus_import: '1'
status: public
title: Topological charges of periodically kicked molecules
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 130
year: '2023'
...
---
_id: '12789'
abstract:
- lang: eng
  text: Experiments have shown that charge distributions of granular materials are
    non-Gaussian, with broad tails that indicate many particles with high charge.
    This observation has consequences for the behavior of granular materials in many
    settings, and may bear relevance to the underlying charge transfer mechanism.
    However, there is the unaddressed possibility that broad tails arise due to experimental
    uncertainties, as determining the shapes of tails is nontrivial. Here we show
    that measurement uncertainties can indeed account for most of the tail broadening
    previously observed. The clue that reveals this is that distributions are sensitive
    to the electric field at which they are measured; ones measured at low (high)
    fields have larger (smaller) tails. Accounting for sources of uncertainty, we
    reproduce this broadening in silico. Finally, we use our results to back out the
    true charge distribution without broadening, which we find is still non-Guassian,
    though with substantially different behavior at the tails and indicating significantly
    fewer highly charged particles. These results have implications in many natural
    settings where electrostatic interactions, especially among highly charged particles,
    strongly affect granular behavior.
acknowledged_ssus:
- _id: M-Shop
acknowledgement: This research was supported by Grants QUIMAL 160001 and Fondecyt
  1221597. This project has received funding from the European Research Council (ERC)
  under the European Union's Horizon 2020 research and innovation programme (Grant
  Agreement No. 949120). This research was supported by the Scientific Service Units
  of The Institute of Science and Technology Austria (ISTA) through resources provided
  by the Miba Machine Shop. We thank the machine shop technical assistance of Ricardo
  Silva and Andrés Espinosa at Departamento de Física, Universidad de Chile.
article_number: '034901'
article_processing_charge: No
article_type: original
author:
- first_name: Nicolás
  full_name: Mujica, Nicolás
  last_name: Mujica
- first_name: Scott R
  full_name: Waitukaitis, Scott R
  id: 3A1FFC16-F248-11E8-B48F-1D18A9856A87
  last_name: Waitukaitis
  orcid: 0000-0002-2299-3176
citation:
  ama: Mujica N, Waitukaitis SR. Accurate determination of the shapes of granular
    charge distributions. <i>Physical Review E</i>. 2023;107(3). doi:<a href="https://doi.org/10.1103/PhysRevE.107.034901">10.1103/PhysRevE.107.034901</a>
  apa: Mujica, N., &#38; Waitukaitis, S. R. (2023). Accurate determination of the
    shapes of granular charge distributions. <i>Physical Review E</i>. American Physical
    Society. <a href="https://doi.org/10.1103/PhysRevE.107.034901">https://doi.org/10.1103/PhysRevE.107.034901</a>
  chicago: Mujica, Nicolás, and Scott R Waitukaitis. “Accurate Determination of the
    Shapes of Granular Charge Distributions.” <i>Physical Review E</i>. American Physical
    Society, 2023. <a href="https://doi.org/10.1103/PhysRevE.107.034901">https://doi.org/10.1103/PhysRevE.107.034901</a>.
  ieee: N. Mujica and S. R. Waitukaitis, “Accurate determination of the shapes of
    granular charge distributions,” <i>Physical Review E</i>, vol. 107, no. 3. American
    Physical Society, 2023.
  ista: Mujica N, Waitukaitis SR. 2023. Accurate determination of the shapes of granular
    charge distributions. Physical Review E. 107(3), 034901.
  mla: Mujica, Nicolás, and Scott R. Waitukaitis. “Accurate Determination of the Shapes
    of Granular Charge Distributions.” <i>Physical Review E</i>, vol. 107, no. 3,
    034901, American Physical Society, 2023, doi:<a href="https://doi.org/10.1103/PhysRevE.107.034901">10.1103/PhysRevE.107.034901</a>.
  short: N. Mujica, S.R. Waitukaitis, Physical Review E 107 (2023).
date_created: 2023-04-02T22:01:10Z
date_published: 2023-03-01T00:00:00Z
date_updated: 2023-11-28T09:22:25Z
day: '01'
ddc:
- '530'
department:
- _id: ScWa
doi: 10.1103/PhysRevE.107.034901
ec_funded: 1
external_id:
  isi:
  - '000992142700001'
file:
- access_level: open_access
  checksum: 48f5dfe4e5f1c46c3c86805cd8f84bea
  content_type: application/pdf
  creator: swaituka
  date_created: 2023-11-27T09:51:48Z
  date_updated: 2023-11-27T09:51:48Z
  file_id: '14612'
  file_name: PhysRevE.107.034901 (1).pdf
  file_size: 1428631
  relation: main_file
  success: 1
file_date_updated: 2023-11-27T09:51:48Z
has_accepted_license: '1'
intvolume: '       107'
isi: 1
issue: '3'
language:
- iso: eng
month: '03'
oa: 1
oa_version: Published Version
project:
- _id: 0aa60e99-070f-11eb-9043-a6de6bdc3afa
  call_identifier: H2020
  grant_number: '949120'
  name: 'Tribocharge: a multi-scale approach to an enduring problem in physics'
publication: Physical Review E
publication_identifier:
  eissn:
  - 2470-0053
  issn:
  - 2470-0045
publication_status: published
publisher: American Physical Society
quality_controlled: '1'
scopus_import: '1'
status: public
title: Accurate determination of the shapes of granular charge distributions
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 107
year: '2023'
...
---
_id: '12790'
abstract:
- lang: eng
  text: Motivated by the recent discoveries of superconductivity in bilayer and trilayer
    graphene, we theoretically investigate superconductivity and other interaction-driven
    phases in multilayer graphene stacks. To this end, we study the density of states
    of multilayer graphene with up to four layers at the single-particle band structure
    level in the presence of a transverse electric field. Among the considered structures,
    tetralayer graphene with rhombohedral (ABCA) stacking reaches the highest density
    of states. We study the phases that can arise in ABCA graphene by tuning the carrier
    density and transverse electric field. For a broad region of the tuning parameters,
    the presence of strong Coulomb repulsion leads to a spontaneous spin and valley
    symmetry breaking via Stoner transitions. Using a model that incorporates the
    spontaneous spin and valley polarization, we explore the Kohn-Luttinger mechanism
    for superconductivity driven by repulsive Coulomb interactions. We find that the
    strongest superconducting instability is in the p-wave channel, and occurs in
    proximity to the onset of Stoner transitions. Interestingly, we find a range of
    densities and transverse electric fields where superconductivity develops out
    of a strongly corrugated, singly connected Fermi surface in each valley, leading
    to a topologically nontrivial chiral p+ip superconducting state with an even number
    of copropagating chiral Majorana edge modes. Our work establishes ABCA-stacked
    tetralayer graphene as a promising platform for observing strongly correlated
    physics and topological superconductivity.
acknowledgement: E.B. and T.H. were supported by the European Research Council (ERC)
  under grant HQMAT (Grant Agreement No. 817799), by the Israel-USA Binational Science
  Foundation (BSF), and by a Research grant from Irving and Cherna Moskowitz.
article_number: '104502'
article_processing_charge: No
article_type: original
arxiv: 1
author:
- first_name: Areg
  full_name: Ghazaryan, Areg
  id: 4AF46FD6-F248-11E8-B48F-1D18A9856A87
  last_name: Ghazaryan
  orcid: 0000-0001-9666-3543
- first_name: Tobias
  full_name: Holder, Tobias
  last_name: Holder
- first_name: Erez
  full_name: Berg, Erez
  last_name: Berg
- first_name: Maksym
  full_name: Serbyn, Maksym
  id: 47809E7E-F248-11E8-B48F-1D18A9856A87
  last_name: Serbyn
  orcid: 0000-0002-2399-5827
citation:
  ama: Ghazaryan A, Holder T, Berg E, Serbyn M. Multilayer graphenes as a platform
    for interaction-driven physics and topological superconductivity. <i>Physical
    Review B</i>. 2023;107(10). doi:<a href="https://doi.org/10.1103/PhysRevB.107.104502">10.1103/PhysRevB.107.104502</a>
  apa: Ghazaryan, A., Holder, T., Berg, E., &#38; Serbyn, M. (2023). Multilayer graphenes
    as a platform for interaction-driven physics and topological superconductivity.
    <i>Physical Review B</i>. American Physical Society. <a href="https://doi.org/10.1103/PhysRevB.107.104502">https://doi.org/10.1103/PhysRevB.107.104502</a>
  chicago: Ghazaryan, Areg, Tobias Holder, Erez Berg, and Maksym Serbyn. “Multilayer
    Graphenes as a Platform for Interaction-Driven Physics and Topological Superconductivity.”
    <i>Physical Review B</i>. American Physical Society, 2023. <a href="https://doi.org/10.1103/PhysRevB.107.104502">https://doi.org/10.1103/PhysRevB.107.104502</a>.
  ieee: A. Ghazaryan, T. Holder, E. Berg, and M. Serbyn, “Multilayer graphenes as
    a platform for interaction-driven physics and topological superconductivity,”
    <i>Physical Review B</i>, vol. 107, no. 10. American Physical Society, 2023.
  ista: Ghazaryan A, Holder T, Berg E, Serbyn M. 2023. Multilayer graphenes as a platform
    for interaction-driven physics and topological superconductivity. Physical Review
    B. 107(10), 104502.
  mla: Ghazaryan, Areg, et al. “Multilayer Graphenes as a Platform for Interaction-Driven
    Physics and Topological Superconductivity.” <i>Physical Review B</i>, vol. 107,
    no. 10, 104502, American Physical Society, 2023, doi:<a href="https://doi.org/10.1103/PhysRevB.107.104502">10.1103/PhysRevB.107.104502</a>.
  short: A. Ghazaryan, T. Holder, E. Berg, M. Serbyn, Physical Review B 107 (2023).
date_created: 2023-04-02T22:01:10Z
date_published: 2023-03-01T00:00:00Z
date_updated: 2023-08-01T13:59:29Z
day: '01'
department:
- _id: MaSe
- _id: MiLe
doi: 10.1103/PhysRevB.107.104502
external_id:
  arxiv:
  - '2211.02492'
  isi:
  - '000945526400003'
intvolume: '       107'
isi: 1
issue: '10'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://doi.org/10.48550/arXiv.2211.02492
month: '03'
oa: 1
oa_version: Preprint
publication: Physical Review B
publication_identifier:
  eissn:
  - 2469-9969
  issn:
  - 2469-9950
publication_status: published
publisher: American Physical Society
quality_controlled: '1'
related_material:
  link:
  - description: News on the ISTA website
    relation: press_release
    url: https://ista.ac.at/en/news/reaching-superconductivity-layer-by-layer/
scopus_import: '1'
status: public
title: Multilayer graphenes as a platform for interaction-driven physics and topological
  superconductivity
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 107
year: '2023'
...
---
_id: '12791'
abstract:
- lang: eng
  text: We investigate the capabilities of Physics-Informed Neural Networks (PINNs)
    to reconstruct turbulent Rayleigh–Bénard flows using only temperature information.
    We perform a quantitative analysis of the quality of the reconstructions at various
    amounts of low-passed-filtered information and turbulent intensities. We compare
    our results with those obtained via nudging, a classical equation-informed data
    assimilation technique. At low Rayleigh numbers, PINNs are able to reconstruct
    with high precision, comparable to the one achieved with nudging. At high Rayleigh
    numbers, PINNs outperform nudging and are able to achieve satisfactory reconstruction
    of the velocity fields only when data for temperature is provided with high spatial
    and temporal density. When data becomes sparse, the PINNs performance worsens,
    not only in a point-to-point error sense but also, and contrary to nudging, in
    a statistical sense, as can be seen in the probability density functions and energy
    spectra.
acknowledgement: This project has received partial funding from the European Research
  Council (ERC) under the European Union’s Horizon 2020 Research and Innovation Programme
  (Grant Agreement No. 882340))
article_number: '16'
article_processing_charge: No
article_type: original
arxiv: 1
author:
- first_name: Patricio
  full_name: Clark Di Leoni, Patricio
  last_name: Clark Di Leoni
- first_name: Lokahith N
  full_name: Agasthya, Lokahith N
  id: cd100965-0804-11ed-9c55-f4878ff4e877
  last_name: Agasthya
- first_name: Michele
  full_name: Buzzicotti, Michele
  last_name: Buzzicotti
- first_name: Luca
  full_name: Biferale, Luca
  last_name: Biferale
citation:
  ama: Clark Di Leoni P, Agasthya LN, Buzzicotti M, Biferale L. Reconstructing Rayleigh–Bénard
    flows out of temperature-only measurements using Physics-Informed Neural Networks.
    <i>The European Physical Journal E</i>. 2023;46(3). doi:<a href="https://doi.org/10.1140/epje/s10189-023-00276-9">10.1140/epje/s10189-023-00276-9</a>
  apa: Clark Di Leoni, P., Agasthya, L. N., Buzzicotti, M., &#38; Biferale, L. (2023).
    Reconstructing Rayleigh–Bénard flows out of temperature-only measurements using
    Physics-Informed Neural Networks. <i>The European Physical Journal E</i>. Springer
    Nature. <a href="https://doi.org/10.1140/epje/s10189-023-00276-9">https://doi.org/10.1140/epje/s10189-023-00276-9</a>
  chicago: Clark Di Leoni, Patricio, Lokahith N Agasthya, Michele Buzzicotti, and
    Luca Biferale. “Reconstructing Rayleigh–Bénard Flows out of Temperature-Only Measurements
    Using Physics-Informed Neural Networks.” <i>The European Physical Journal E</i>.
    Springer Nature, 2023. <a href="https://doi.org/10.1140/epje/s10189-023-00276-9">https://doi.org/10.1140/epje/s10189-023-00276-9</a>.
  ieee: P. Clark Di Leoni, L. N. Agasthya, M. Buzzicotti, and L. Biferale, “Reconstructing
    Rayleigh–Bénard flows out of temperature-only measurements using Physics-Informed
    Neural Networks,” <i>The European Physical Journal E</i>, vol. 46, no. 3. Springer
    Nature, 2023.
  ista: Clark Di Leoni P, Agasthya LN, Buzzicotti M, Biferale L. 2023. Reconstructing
    Rayleigh–Bénard flows out of temperature-only measurements using Physics-Informed
    Neural Networks. The European Physical Journal E. 46(3), 16.
  mla: Clark Di Leoni, Patricio, et al. “Reconstructing Rayleigh–Bénard Flows out
    of Temperature-Only Measurements Using Physics-Informed Neural Networks.” <i>The
    European Physical Journal E</i>, vol. 46, no. 3, 16, Springer Nature, 2023, doi:<a
    href="https://doi.org/10.1140/epje/s10189-023-00276-9">10.1140/epje/s10189-023-00276-9</a>.
  short: P. Clark Di Leoni, L.N. Agasthya, M. Buzzicotti, L. Biferale, The European
    Physical Journal E 46 (2023).
date_created: 2023-04-02T22:01:11Z
date_published: 2023-03-20T00:00:00Z
date_updated: 2023-08-01T14:03:47Z
day: '20'
department:
- _id: CaMu
doi: 10.1140/epje/s10189-023-00276-9
external_id:
  arxiv:
  - '2301.07769'
  isi:
  - '000956387200001'
intvolume: '        46'
isi: 1
issue: '3'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: ' https://doi.org/10.48550/arXiv.2301.07769'
month: '03'
oa: 1
oa_version: Preprint
publication: The European Physical Journal E
publication_identifier:
  eissn:
  - 1292-895X
  issn:
  - 1292-8941
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
scopus_import: '1'
status: public
title: Reconstructing Rayleigh–Bénard flows out of temperature-only measurements using
  Physics-Informed Neural Networks
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 46
year: '2023'
...
---
_id: '12792'
abstract:
- lang: eng
  text: In the physics literature the spectral form factor (SFF), the squared Fourier
    transform of the empirical eigenvalue density, is the most common tool to test
    universality for disordered quantum systems, yet previous mathematical results
    have been restricted only to two exactly solvable models (Forrester in J Stat
    Phys 183:33, 2021. https://doi.org/10.1007/s10955-021-02767-5, Commun Math Phys
    387:215–235, 2021. https://doi.org/10.1007/s00220-021-04193-w). We rigorously
    prove the physics prediction on SFF up to an intermediate time scale for a large
    class of random matrices using a robust method, the multi-resolvent local laws.
    Beyond Wigner matrices we also consider the monoparametric ensemble and prove
    that universality of SFF can already be triggered by a single random parameter,
    supplementing the recently proven Wigner–Dyson universality (Cipolloni et al.
    in Probab Theory Relat Fields, 2021. https://doi.org/10.1007/s00440-022-01156-7)
    to larger spectral scales. Remarkably, extensive numerics indicates that our formulas
    correctly predict the SFF in the entire slope-dip-ramp regime, as customarily
    called in physics.
acknowledgement: "We are grateful to the authors of [25] for sharing with us their
  insights and preliminary numerical results. We are especially thankful to Stephen
  Shenker for very valuable advice over several email communications. Helpful comments
  on the manuscript from Peter Forrester and from the anonymous referees are also
  acknowledged.\r\nOpen access funding provided by Institute of Science and Technology
  (IST Austria).\r\nLászló Erdős: Partially supported by ERC Advanced Grant \"RMTBeyond\"
  No. 101020331. Dominik Schröder: Supported by Dr. Max Rössler, the Walter Haefner
  Foundation and the ETH Zürich Foundation."
article_processing_charge: Yes (via OA deal)
article_type: original
author:
- first_name: Giorgio
  full_name: Cipolloni, Giorgio
  id: 42198EFA-F248-11E8-B48F-1D18A9856A87
  last_name: Cipolloni
  orcid: 0000-0002-4901-7992
- first_name: László
  full_name: Erdös, László
  id: 4DBD5372-F248-11E8-B48F-1D18A9856A87
  last_name: Erdös
  orcid: 0000-0001-5366-9603
- first_name: Dominik J
  full_name: Schröder, Dominik J
  id: 408ED176-F248-11E8-B48F-1D18A9856A87
  last_name: Schröder
  orcid: 0000-0002-2904-1856
citation:
  ama: Cipolloni G, Erdös L, Schröder DJ. On the spectral form factor for random matrices.
    <i>Communications in Mathematical Physics</i>. 2023;401:1665-1700. doi:<a href="https://doi.org/10.1007/s00220-023-04692-y">10.1007/s00220-023-04692-y</a>
  apa: Cipolloni, G., Erdös, L., &#38; Schröder, D. J. (2023). On the spectral form
    factor for random matrices. <i>Communications in Mathematical Physics</i>. Springer
    Nature. <a href="https://doi.org/10.1007/s00220-023-04692-y">https://doi.org/10.1007/s00220-023-04692-y</a>
  chicago: Cipolloni, Giorgio, László Erdös, and Dominik J Schröder. “On the Spectral
    Form Factor for Random Matrices.” <i>Communications in Mathematical Physics</i>.
    Springer Nature, 2023. <a href="https://doi.org/10.1007/s00220-023-04692-y">https://doi.org/10.1007/s00220-023-04692-y</a>.
  ieee: G. Cipolloni, L. Erdös, and D. J. Schröder, “On the spectral form factor for
    random matrices,” <i>Communications in Mathematical Physics</i>, vol. 401. Springer
    Nature, pp. 1665–1700, 2023.
  ista: Cipolloni G, Erdös L, Schröder DJ. 2023. On the spectral form factor for random
    matrices. Communications in Mathematical Physics. 401, 1665–1700.
  mla: Cipolloni, Giorgio, et al. “On the Spectral Form Factor for Random Matrices.”
    <i>Communications in Mathematical Physics</i>, vol. 401, Springer Nature, 2023,
    pp. 1665–700, doi:<a href="https://doi.org/10.1007/s00220-023-04692-y">10.1007/s00220-023-04692-y</a>.
  short: G. Cipolloni, L. Erdös, D.J. Schröder, Communications in Mathematical Physics
    401 (2023) 1665–1700.
date_created: 2023-04-02T22:01:11Z
date_published: 2023-07-01T00:00:00Z
date_updated: 2023-10-04T12:10:31Z
day: '01'
ddc:
- '510'
department:
- _id: LaEr
doi: 10.1007/s00220-023-04692-y
ec_funded: 1
external_id:
  isi:
  - '000957343500001'
file:
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  file_size: 859967
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intvolume: '       401'
isi: 1
language:
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month: '07'
oa: 1
oa_version: Published Version
page: 1665-1700
project:
- _id: 62796744-2b32-11ec-9570-940b20777f1d
  call_identifier: H2020
  grant_number: '101020331'
  name: Random matrices beyond Wigner-Dyson-Mehta
publication: Communications in Mathematical Physics
publication_identifier:
  eissn:
  - 1432-0916
  issn:
  - 0010-3616
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
scopus_import: '1'
status: public
title: On the spectral form factor for random matrices
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 401
year: '2023'
...
---
_id: '12800'
abstract:
- lang: eng
  text: 'The evolutionary processes that brought about today’s plethora of living
    species and the many billions more ancient ones all underlie biology. Evolutionary
    pathways are neither directed nor deterministic, but rather an interplay between
    selection, migration, mutation, genetic drift and other environmental factors.
    Hybrid zones, as natural crossing experiments, offer a great opportunity to use
    cline analysis to deduce different evolutionary processes - for example, selection
    strength. Theoretical cline models, largely assuming uniform distribution of individuals,
    often lack the capability of incorporating population structure. Since in reality
    organisms mostly live in patchy distributions and their dispersal is hardly ever
    Gaussian, it is necessary to unravel the effect of these different elements of
    population structure on cline parameters and shape. In this thesis, I develop
    a simulation inspired by the A. majus hybrid zone of a single selected locus under
    frequency dependent selection. This simulation enables us to untangle the effects
    of different elements of population structure as for example a low-density center
    and long-range dispersal. This thesis is therefore a first step towards theoretically
    untangling the effects of different elements of population structure on cline
    parameters and shape. '
alternative_title:
- ISTA Master's Thesis
article_processing_charge: No
author:
- first_name: Mara
  full_name: Julseth, Mara
  id: 1cf464b2-dc7d-11ea-9b2f-f9b1aa9417d1
  last_name: Julseth
citation:
  ama: Julseth M. The effect of local population structure on genetic variation at
    selected loci in the A. majus hybrid zone. 2023. doi:<a href="https://doi.org/10.15479/at:ista:12800">10.15479/at:ista:12800</a>
  apa: Julseth, M. (2023). <i>The effect of local population structure on genetic
    variation at selected loci in the A. majus hybrid zone</i>. Institute of Science
    and Technology Austria. <a href="https://doi.org/10.15479/at:ista:12800">https://doi.org/10.15479/at:ista:12800</a>
  chicago: Julseth, Mara. “The Effect of Local Population Structure on Genetic Variation
    at Selected Loci in the A. Majus Hybrid Zone.” Institute of Science and Technology
    Austria, 2023. <a href="https://doi.org/10.15479/at:ista:12800">https://doi.org/10.15479/at:ista:12800</a>.
  ieee: M. Julseth, “The effect of local population structure on genetic variation
    at selected loci in the A. majus hybrid zone,” Institute of Science and Technology
    Austria, 2023.
  ista: Julseth M. 2023. The effect of local population structure on genetic variation
    at selected loci in the A. majus hybrid zone. Institute of Science and Technology
    Austria.
  mla: Julseth, Mara. <i>The Effect of Local Population Structure on Genetic Variation
    at Selected Loci in the A. Majus Hybrid Zone</i>. Institute of Science and Technology
    Austria, 2023, doi:<a href="https://doi.org/10.15479/at:ista:12800">10.15479/at:ista:12800</a>.
  short: M. Julseth, The Effect of Local Population Structure on Genetic Variation
    at Selected Loci in the A. Majus Hybrid Zone, Institute of Science and Technology
    Austria, 2023.
date_created: 2023-04-04T18:57:11Z
date_published: 2023-04-05T00:00:00Z
date_updated: 2023-06-02T22:30:05Z
day: '05'
ddc:
- '576'
degree_awarded: MS
department:
- _id: GradSch
- _id: NiBa
doi: 10.15479/at:ista:12800
file:
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  date_created: 2023-04-06T06:09:40Z
  date_updated: 2023-06-02T22:30:04Z
  embargo_to: open_access
  file_id: '12805'
  file_name: Dispersaldata.xlsx
  file_size: 52795
  relation: supplementary_material
- access_level: open_access
  checksum: 5a13b6d204371572e249f03795bc0d04
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  creator: mjulseth
  date_created: 2023-04-06T06:11:27Z
  date_updated: 2023-06-02T22:30:04Z
  embargo: 2023-06-01
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  date_updated: 2023-06-02T22:30:04Z
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  file_size: 1061763
  relation: source_file
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  date_updated: 2023-06-02T22:30:04Z
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file_date_updated: 2023-06-02T22:30:04Z
has_accepted_license: '1'
language:
- iso: eng
month: '04'
oa: 1
oa_version: Published Version
page: '21'
publication_identifier:
  issn:
  - 2791-4585
publication_status: published
publisher: Institute of Science and Technology Austria
status: public
supervisor:
- first_name: Nicholas H
  full_name: Barton, Nicholas H
  id: 4880FE40-F248-11E8-B48F-1D18A9856A87
  last_name: Barton
  orcid: 0000-0002-8548-5240
title: The effect of local population structure on genetic variation at selected loci
  in the A. majus hybrid zone
type: dissertation
user_id: 8b945eb4-e2f2-11eb-945a-df72226e66a9
year: '2023'
...
---
_id: '12802'
abstract:
- lang: eng
  text: Little is known about the critical metabolic changes that neural cells have
    to undergo during development and how temporary shifts in this program can influence
    brain circuitries and behavior. Inspired by the discovery that mutations in SLC7A5,
    a transporter of metabolically essential large neutral amino acids (LNAAs), lead
    to autism, we employed metabolomic profiling to study the metabolic states of
    the cerebral cortex across different developmental stages. We found that the forebrain
    undergoes significant metabolic remodeling throughout development, with certain
    groups of metabolites showing stage-specific changes, but what are the consequences
    of perturbing this metabolic program? By manipulating Slc7a5 expression in neural
    cells, we found that the metabolism of LNAAs and lipids are interconnected in
    the cortex. Deletion of Slc7a5 in neurons affects the postnatal metabolic state,
    leading to a shift in lipid metabolism. Additionally, it causes stage- and cell-type-specific
    alterations in neuronal activity patterns, resulting in a long-term circuit dysfunction.
acknowledged_ssus:
- _id: PreCl
- _id: EM-Fac
- _id: Bio
- _id: LifeSc
acknowledgement: We thank A. Freeman and V. Voronin for technical assistance, S. Deixler,
  A. Stichelberger, M. Schunn, and the Preclinical Facility for managing our animal
  colony. We thank L. Andersen and J. Sonntag, who were involved in generating the
  MADM lines. We thank the ISTA LSF Mass Spectrometry Core Facility for assistance
  with the proteomic analysis, as well as the ISTA electron microscopy and Imaging
  and Optics facility for technical support. Metabolomics LC-MS/MS analysis was performed
  by the Metabolomics Facility at Vienna BioCenter Core Facilities (VBCF). We acknowledge
  the support of the EMBL Metabolomics Core Facility (MCF) for lipidomics and intracellular
  metabolomics mass spectrometry data acquisition and analysis. RNA sequencing was
  performed by the Next Generation Sequencing Facility at VBCF. Schematics were generated
  using Biorender.com. This work was supported by the Austrian Science Fund (FWF,
  DK W1232-B24) and by the European Union’s Horizon 2020 research and innovation program
  (ERC) grant 725780 (LinPro) to S.H. and 715508 (REVERSEAUTISM) to G.N.
article_processing_charge: Yes (via OA deal)
article_type: original
author:
- first_name: Lisa
  full_name: Knaus, Lisa
  id: 3B2ABCF4-F248-11E8-B48F-1D18A9856A87
  last_name: Knaus
- first_name: Bernadette
  full_name: Basilico, Bernadette
  id: 36035796-5ACA-11E9-A75E-7AF2E5697425
  last_name: Basilico
  orcid: 0000-0003-1843-3173
- first_name: Daniel
  full_name: Malzl, Daniel
  last_name: Malzl
- first_name: Maria
  full_name: Gerykova Bujalkova, Maria
  last_name: Gerykova Bujalkova
- first_name: Mateja
  full_name: Smogavec, Mateja
  last_name: Smogavec
- first_name: Lena A.
  full_name: Schwarz, Lena A.
  last_name: Schwarz
- first_name: Sarah
  full_name: Gorkiewicz, Sarah
  id: f141a35d-15a9-11ec-9fb2-fef6becc7b6f
  last_name: Gorkiewicz
- first_name: Nicole
  full_name: Amberg, Nicole
  id: 4CD6AAC6-F248-11E8-B48F-1D18A9856A87
  last_name: Amberg
  orcid: 0000-0002-3183-8207
- first_name: Florian
  full_name: Pauler, Florian
  id: 48EA0138-F248-11E8-B48F-1D18A9856A87
  last_name: Pauler
  orcid: 0000-0002-7462-0048
- first_name: Christian
  full_name: Knittl-Frank, Christian
  last_name: Knittl-Frank
- first_name: Marianna
  full_name: Tassinari, Marianna
  id: 7af593f1-d44a-11ed-bf94-a3646a6bb35e
  last_name: Tassinari
- first_name: Nuno
  full_name: Maulide, Nuno
  last_name: Maulide
- first_name: Thomas
  full_name: Rülicke, Thomas
  last_name: Rülicke
- first_name: Jörg
  full_name: Menche, Jörg
  last_name: Menche
- first_name: Simon
  full_name: Hippenmeyer, Simon
  id: 37B36620-F248-11E8-B48F-1D18A9856A87
  last_name: Hippenmeyer
  orcid: 0000-0003-2279-1061
- first_name: Gaia
  full_name: Novarino, Gaia
  id: 3E57A680-F248-11E8-B48F-1D18A9856A87
  last_name: Novarino
  orcid: 0000-0002-7673-7178
citation:
  ama: Knaus L, Basilico B, Malzl D, et al. Large neutral amino acid levels tune perinatal
    neuronal excitability and survival. <i>Cell</i>. 2023;186(9):1950-1967.e25. doi:<a
    href="https://doi.org/10.1016/j.cell.2023.02.037">10.1016/j.cell.2023.02.037</a>
  apa: Knaus, L., Basilico, B., Malzl, D., Gerykova Bujalkova, M., Smogavec, M., Schwarz,
    L. A., … Novarino, G. (2023). Large neutral amino acid levels tune perinatal neuronal
    excitability and survival. <i>Cell</i>. Elsevier. <a href="https://doi.org/10.1016/j.cell.2023.02.037">https://doi.org/10.1016/j.cell.2023.02.037</a>
  chicago: Knaus, Lisa, Bernadette Basilico, Daniel Malzl, Maria Gerykova Bujalkova,
    Mateja Smogavec, Lena A. Schwarz, Sarah Gorkiewicz, et al. “Large Neutral Amino
    Acid Levels Tune Perinatal Neuronal Excitability and Survival.” <i>Cell</i>. Elsevier,
    2023. <a href="https://doi.org/10.1016/j.cell.2023.02.037">https://doi.org/10.1016/j.cell.2023.02.037</a>.
  ieee: L. Knaus <i>et al.</i>, “Large neutral amino acid levels tune perinatal neuronal
    excitability and survival,” <i>Cell</i>, vol. 186, no. 9. Elsevier, p. 1950–1967.e25,
    2023.
  ista: Knaus L, Basilico B, Malzl D, Gerykova Bujalkova M, Smogavec M, Schwarz LA,
    Gorkiewicz S, Amberg N, Pauler F, Knittl-Frank C, Tassinari M, Maulide N, Rülicke
    T, Menche J, Hippenmeyer S, Novarino G. 2023. Large neutral amino acid levels
    tune perinatal neuronal excitability and survival. Cell. 186(9), 1950–1967.e25.
  mla: Knaus, Lisa, et al. “Large Neutral Amino Acid Levels Tune Perinatal Neuronal
    Excitability and Survival.” <i>Cell</i>, vol. 186, no. 9, Elsevier, 2023, p. 1950–1967.e25,
    doi:<a href="https://doi.org/10.1016/j.cell.2023.02.037">10.1016/j.cell.2023.02.037</a>.
  short: L. Knaus, B. Basilico, D. Malzl, M. Gerykova Bujalkova, M. Smogavec, L.A.
    Schwarz, S. Gorkiewicz, N. Amberg, F. Pauler, C. Knittl-Frank, M. Tassinari, N.
    Maulide, T. Rülicke, J. Menche, S. Hippenmeyer, G. Novarino, Cell 186 (2023) 1950–1967.e25.
date_created: 2023-04-05T08:15:40Z
date_published: 2023-04-27T00:00:00Z
date_updated: 2024-02-07T08:03:32Z
day: '27'
ddc:
- '570'
department:
- _id: SiHi
- _id: GaNo
doi: 10.1016/j.cell.2023.02.037
ec_funded: 1
external_id:
  isi:
  - '000991468700001'
file:
- access_level: open_access
  checksum: 47e94fbe19e86505b429cb7a5b503ce6
  content_type: application/pdf
  creator: dernst
  date_created: 2023-05-02T09:26:21Z
  date_updated: 2023-05-02T09:26:21Z
  file_id: '12889'
  file_name: 2023_Cell_Knaus.pdf
  file_size: 15712841
  relation: main_file
  success: 1
file_date_updated: 2023-05-02T09:26:21Z
has_accepted_license: '1'
intvolume: '       186'
isi: 1
issue: '9'
keyword:
- General Biochemistry
- Genetics and Molecular Biology
language:
- iso: eng
month: '04'
oa: 1
oa_version: Published Version
page: 1950-1967.e25
project:
- _id: 2548AE96-B435-11E9-9278-68D0E5697425
  call_identifier: FWF
  grant_number: W1232-B24
  name: Molecular Drug Targets
- _id: 260018B0-B435-11E9-9278-68D0E5697425
  call_identifier: H2020
  grant_number: '725780'
  name: Principles of Neural Stem Cell Lineage Progression in Cerebral Cortex Development
- _id: 25444568-B435-11E9-9278-68D0E5697425
  call_identifier: H2020
  grant_number: '715508'
  name: Probing the Reversibility of Autism Spectrum Disorders by Employing in vivo
    and in vitro Models
publication: Cell
publication_identifier:
  issn:
  - 0092-8674
publication_status: published
publisher: Elsevier
quality_controlled: '1'
related_material:
  link:
  - description: News on ISTA Website
    relation: press_release
    url: https://ista.ac.at/en/news/feed-them-or-lose-them/
  record:
  - id: '13107'
    relation: dissertation_contains
    status: public
scopus_import: '1'
status: public
title: Large neutral amino acid levels tune perinatal neuronal excitability and survival
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 186
year: '2023'
...
---
_id: '12809'
abstract:
- lang: eng
  text: "Understanding the mechanisms of learning and memory formation has always
    been one of\r\nthe main goals in neuroscience. Already Pavlov (1927) in his early
    days has used his classic\r\nconditioning experiments to study the neural mechanisms
    governing behavioral adaptation.\r\nWhat was not known back then was that the
    part of the brain that is largely responsible for\r\nthis type of associative
    learning is the cerebellum.\r\nSince then, plenty of theories on cerebellar learning
    have emerged. Despite their differences,\r\none thing they all have in common
    is that learning relies on synaptic and intrinsic plasticity.\r\nThe goal of my
    PhD project was to unravel the molecular mechanisms underlying synaptic\r\nplasticity
    in two synapses that have been shown to be implicated in motor learning, in an\r\neffort
    to understand how learning and memory formation are processed in the cerebellum.\r\nOne
    of the earliest and most well-known cerebellar theories postulates that motor
    learning\r\nlargely depends on long-term depression at the parallel fiber-Purkinje
    cell (PC-PC) synapse.\r\nHowever, the discovery of other types of plasticity in
    the cerebellar circuitry, like long-term\r\npotentiation (LTP) at the PC-PC synapse,
    potentiation of molecular layer interneurons (MLIs),\r\nand plasticity transfer
    from the cortex to the cerebellar/ vestibular nuclei has increased the\r\npopularity
    of the idea that multiple sites of plasticity might be involved in learning.\r\nStill
    a lot remains unknown about the molecular mechanisms responsible for these types
    of\r\nplasticity and whether they occur during physiological learning.\r\nIn the
    first part of this thesis we have analyzed the variation and nanodistribution
    of voltagegated calcium channels (VGCCs) and α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic
    acid\r\ntype glutamate receptors (AMPARs) on the parallel fiber-Purkinje cell
    synapse after vestibuloocular reflex phase reversal adaptation, a behavior that
    has been suggested to rely on PF-PC\r\nLTP. We have found that on the last day
    of adaptation there is no learning trace in form of\r\nVGCCs nor AMPARs variation
    at the PF-PC synapse, but instead a decrease in the number of\r\nPF-PC synapses.
    These data seem to support the view that learning is only stored in the\r\ncerebellar
    cortex in an initial learning phase, being transferred later to the vestibular
    nuclei.\r\nNext, we have studied the role of MLIs in motor learning using a relatively
    simple and well characterized behavioral paradigm – horizontal optokinetic reflex
    (HOKR) adaptation. We\r\nhave found behavior-induced MLI potentiation in form
    of release probability increase that\r\ncould be explained by the increase of
    VGCCs at the presynaptic side. Our results strengthen\r\nthe idea of distributed
    cerebellar plasticity contributing to learning and provide a novel\r\nmechanism
    for release probability increase. "
acknowledged_ssus:
- _id: EM-Fac
- _id: Bio
- _id: PreCl
alternative_title:
- ISTA Thesis
article_processing_charge: No
author:
- first_name: Catarina
  full_name: Alcarva, Catarina
  id: 3A96634C-F248-11E8-B48F-1D18A9856A87
  last_name: Alcarva
citation:
  ama: 'Alcarva C. Plasticity in the cerebellum: What molecular mechanisms are behind
    physiological learning. 2023. doi:<a href="https://doi.org/10.15479/at:ista:12809">10.15479/at:ista:12809</a>'
  apa: 'Alcarva, C. (2023). <i>Plasticity in the cerebellum: What molecular mechanisms
    are behind physiological learning</i>. Institute of Science and Technology Austria.
    <a href="https://doi.org/10.15479/at:ista:12809">https://doi.org/10.15479/at:ista:12809</a>'
  chicago: 'Alcarva, Catarina. “Plasticity in the Cerebellum: What Molecular Mechanisms
    Are behind Physiological Learning.” Institute of Science and Technology Austria,
    2023. <a href="https://doi.org/10.15479/at:ista:12809">https://doi.org/10.15479/at:ista:12809</a>.'
  ieee: 'C. Alcarva, “Plasticity in the cerebellum: What molecular mechanisms are
    behind physiological learning,” Institute of Science and Technology Austria, 2023.'
  ista: 'Alcarva C. 2023. Plasticity in the cerebellum: What molecular mechanisms
    are behind physiological learning. Institute of Science and Technology Austria.'
  mla: 'Alcarva, Catarina. <i>Plasticity in the Cerebellum: What Molecular Mechanisms
    Are behind Physiological Learning</i>. Institute of Science and Technology Austria,
    2023, doi:<a href="https://doi.org/10.15479/at:ista:12809">10.15479/at:ista:12809</a>.'
  short: 'C. Alcarva, Plasticity in the Cerebellum: What Molecular Mechanisms Are
    behind Physiological Learning, Institute of Science and Technology Austria, 2023.'
date_created: 2023-04-06T07:54:09Z
date_published: 2023-04-06T00:00:00Z
date_updated: 2023-04-26T12:16:56Z
day: '06'
ddc:
- '570'
degree_awarded: PhD
department:
- _id: GradSch
- _id: RySh
doi: 10.15479/at:ista:12809
file:
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  date_updated: 2023-04-07T06:16:06Z
  embargo: 2024-04-07
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has_accepted_license: '1'
language:
- iso: eng
month: '04'
oa_version: Published Version
page: '115'
project:
- _id: 267DFB90-B435-11E9-9278-68D0E5697425
  name: 'Plasticity in the cerebellum: Which molecular mechanisms are behind physiological
    learning?'
publication_identifier:
  issn:
  - 2663 - 337X
publication_status: published
publisher: Institute of Science and Technology Austria
status: public
supervisor:
- first_name: Ryuichi
  full_name: Shigemoto, Ryuichi
  id: 499F3ABC-F248-11E8-B48F-1D18A9856A87
  last_name: Shigemoto
  orcid: 0000-0001-8761-9444
title: 'Plasticity in the cerebellum: What molecular mechanisms are behind physiological
  learning'
type: dissertation
user_id: 8b945eb4-e2f2-11eb-945a-df72226e66a9
year: '2023'
...
---
_id: '12817'
abstract:
- lang: eng
  text: 3D-reconstruction of living brain tissue down to individual synapse level
    would create opportunities for decoding the dynamics and structure-function relationships
    of the brain’s complex and dense information processing network. However, it has
    been hindered by insufficient 3D-resolution, inadequate signal-to-noise-ratio,
    and prohibitive light burden in optical imaging, whereas electron microscopy is
    inherently static. Here we solved these challenges by developing an integrated
    optical/machine learning technology, LIONESS (Live Information-Optimized Nanoscopy
    Enabling Saturated Segmentation). It leverages optical modifications to stimulated
    emission depletion (STED) microscopy in comprehensively, extracellularly labelled
    tissue and prior information on sample structure via machine learning to simultaneously
    achieve isotropic super-resolution, high signal-to-noise-ratio, and compatibility
    with living tissue. This allows dense deep-learning-based instance segmentation
    and 3D-reconstruction at synapse level incorporating molecular, activity, and
    morphodynamic information. LIONESS opens up avenues for studying the dynamic functional
    (nano-)architecture of living brain tissue.
acknowledged_ssus:
- _id: ScienComp
- _id: Bio
- _id: PreCl
- _id: LifeSc
- _id: M-Shop
- _id: E-Lib
acknowledgement: 'We thank J. Vorlaufer, N. Agudelo, A. Wartak for microscope maintenance
  and troubleshooting, C. Kreuzinger and A. Freeman for technical assistance, and
  M. Šuplata for hardware control support, and Márcia Cunha dos Santos for initial
  exploration of software. We thank Paul Henderson for advice on deep-learning training
  and Michael Sixt, Scott Boyd, and Tamara Weiss for discussions and critical reading
  of the manuscript. Luke Lavis (Janelia Research Campus) generously provided JF585-HaloTag
  ligand. '
article_processing_charge: No
author:
- first_name: Johann G
  full_name: Danzl, Johann G
  id: 42EFD3B6-F248-11E8-B48F-1D18A9856A87
  last_name: Danzl
  orcid: 0000-0001-8559-3973
citation:
  ama: Danzl JG. Research data for the publication “Dense 4D nanoscale reconstruction
    of living brain tissue.” 2023. doi:<a href="https://doi.org/10.15479/AT:ISTA:12817">10.15479/AT:ISTA:12817</a>
  apa: Danzl, J. G. (2023). Research data for the publication “Dense 4D nanoscale
    reconstruction of living brain tissue.” Institute of Science and Technology Austria.
    <a href="https://doi.org/10.15479/AT:ISTA:12817">https://doi.org/10.15479/AT:ISTA:12817</a>
  chicago: Danzl, Johann G. “Research Data for the Publication ‘Dense 4D Nanoscale
    Reconstruction of Living Brain Tissue.’” Institute of Science and Technology Austria,
    2023. <a href="https://doi.org/10.15479/AT:ISTA:12817">https://doi.org/10.15479/AT:ISTA:12817</a>.
  ieee: J. G. Danzl, “Research data for the publication ‘Dense 4D nanoscale reconstruction
    of living brain tissue.’” Institute of Science and Technology Austria, 2023.
  ista: Danzl JG. 2023. Research data for the publication ‘Dense 4D nanoscale reconstruction
    of living brain tissue’, Institute of Science and Technology Austria, <a href="https://doi.org/10.15479/AT:ISTA:12817">10.15479/AT:ISTA:12817</a>.
  mla: Danzl, Johann G. <i>Research Data for the Publication “Dense 4D Nanoscale Reconstruction
    of Living Brain Tissue.”</i> Institute of Science and Technology Austria, 2023,
    doi:<a href="https://doi.org/10.15479/AT:ISTA:12817">10.15479/AT:ISTA:12817</a>.
  short: J.G. Danzl, (2023).
contributor:
- first_name: Philipp
  id: 39BDC62C-F248-11E8-B48F-1D18A9856A87
  last_name: Velicky
  orcid: 0000-0002-2340-7431
- first_name: Eder
  id: 3FB91342-F248-11E8-B48F-1D18A9856A87
  last_name: Miguel Villalba
- first_name: Julia M
  id: 443DB6DE-F248-11E8-B48F-1D18A9856A87
  last_name: Michalska
- first_name: Julia
  id: 46E28B80-F248-11E8-B48F-1D18A9856A87
  last_name: Lyudchik
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  last_name: Lin
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  id: 63836096-4690-11EA-BD4E-32803DDC885E
  last_name: Watson
  orcid: 0000-0002-8698-3823
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  id: 43DF3136-F248-11E8-B48F-1D18A9856A87
  last_name: Ben Simon
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  id: 4DF26D8C-F248-11E8-B48F-1D18A9856A87
  last_name: Sommer
  orcid: 0000-0003-1216-9105
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  last_name: Grant
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  id: 353C1B58-F248-11E8-B48F-1D18A9856A87
  last_name: Jonas
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  id: 49876194-F248-11E8-B48F-1D18A9856A87
  last_name: Bickel
  orcid: 0000-0001-6511-9385
date_created: 2023-04-07T11:37:40Z
date_published: 2023-05-19T00:00:00Z
date_updated: 2024-01-10T08:37:48Z
day: '19'
ddc:
- '570'
department:
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doi: 10.15479/AT:ISTA:12817
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license: https://creativecommons.org/licenses/by-sa/4.0/
month: '05'
oa: 1
oa_version: Published Version
publisher: Institute of Science and Technology Austria
related_material:
  record:
  - id: '13267'
    relation: used_in_publication
    status: public
status: public
title: Research data for the publication "Dense 4D nanoscale reconstruction of living
  brain tissue"
tmp:
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  legal_code_url: https://creativecommons.org/licenses/by-sa/4.0/legalcode
  name: Creative Commons Attribution-ShareAlike 4.0 International Public License (CC
    BY-SA 4.0)
  short: CC BY-SA (4.0)
type: research_data
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '2023'
...
---
_id: '12818'
abstract:
- lang: eng
  text: The multicellular organization of diverse systems, including embryos, intestines,
    and tumors relies on coordinated cell migration in curved environments. In these
    settings, cells establish supracellular patterns of motion, including collective
    rotation and invasion. While such collective modes have been studied extensively
    in flat systems, the consequences of geometrical and topological constraints on
    collective migration in curved systems are largely unknown. Here, we discover
    a collective mode of cell migration in rotating spherical tissues manifesting
    as a propagating single-wavelength velocity wave. This wave is accompanied by
    an apparently incompressible supracellular flow pattern featuring topological
    defects as dictated by the spherical topology. Using a minimal active particle
    model, we reveal that this collective mode arises from the effect of curvature
    on the active flocking behavior of a cell layer confined to a spherical surface.
    Our results thus identify curvature-induced velocity waves as a mode of collective
    cell migration, impacting the dynamical organization of 3D curved tissues.
acknowledgement: We thank H. Abbaszadeh, M.J. Bowick, G. Gradziuk, M.C. Marchetti,
  and S. Shankar for their helpful discussions. Funded by the Deutsche Forschungsgemeinschaft
  (DFG, German Research Foundation)—Project-ID 201269156-SFB 1032 (Project B12). D.B.B.
  is a NOMIS fellow supported by the NOMIS foundation and was in part supported by
  a DFG fellowship within the Graduate School of Quantitative Biosciences Munich (QBM)
  and Joachim Herz Stiftung. R.A. acknowledges support from the Human Frontier Science
  Program (LT000475/2018-C) and from the National Science Foundation, through the
  Center for the Physics of Biological Function (PHY-1734030). M.G. acknowledges support
  from NIH R01GM140108 and Alfred Sloan Foundation. Funded by the Deutsche Forschungsgemeinschaft
  (DFG, German Research Foundation)—Project-ID 201269156-SFB 1032 (Project B12).Open
  Access funding enabled and organized by Projekt DEAL.
article_number: '1643'
article_processing_charge: No
article_type: original
author:
- first_name: Tom
  full_name: Brandstätter, Tom
  last_name: Brandstätter
- first_name: David
  full_name: Brückner, David
  id: e1e86031-6537-11eb-953a-f7ab92be508d
  last_name: Brückner
  orcid: 0000-0001-7205-2975
- first_name: Yu Long
  full_name: Han, Yu Long
  last_name: Han
- first_name: Ricard
  full_name: Alert, Ricard
  last_name: Alert
- first_name: Ming
  full_name: Guo, Ming
  last_name: Guo
- first_name: Chase P.
  full_name: Broedersz, Chase P.
  last_name: Broedersz
citation:
  ama: Brandstätter T, Brückner D, Han YL, Alert R, Guo M, Broedersz CP. Curvature
    induces active velocity waves in rotating spherical tissues. <i>Nature Communications</i>.
    2023;14. doi:<a href="https://doi.org/10.1038/s41467-023-37054-2">10.1038/s41467-023-37054-2</a>
  apa: Brandstätter, T., Brückner, D., Han, Y. L., Alert, R., Guo, M., &#38; Broedersz,
    C. P. (2023). Curvature induces active velocity waves in rotating spherical tissues.
    <i>Nature Communications</i>. Springer Nature. <a href="https://doi.org/10.1038/s41467-023-37054-2">https://doi.org/10.1038/s41467-023-37054-2</a>
  chicago: Brandstätter, Tom, David Brückner, Yu Long Han, Ricard Alert, Ming Guo,
    and Chase P. Broedersz. “Curvature Induces Active Velocity Waves in Rotating Spherical
    Tissues.” <i>Nature Communications</i>. Springer Nature, 2023. <a href="https://doi.org/10.1038/s41467-023-37054-2">https://doi.org/10.1038/s41467-023-37054-2</a>.
  ieee: T. Brandstätter, D. Brückner, Y. L. Han, R. Alert, M. Guo, and C. P. Broedersz,
    “Curvature induces active velocity waves in rotating spherical tissues,” <i>Nature
    Communications</i>, vol. 14. Springer Nature, 2023.
  ista: Brandstätter T, Brückner D, Han YL, Alert R, Guo M, Broedersz CP. 2023. Curvature
    induces active velocity waves in rotating spherical tissues. Nature Communications.
    14, 1643.
  mla: Brandstätter, Tom, et al. “Curvature Induces Active Velocity Waves in Rotating
    Spherical Tissues.” <i>Nature Communications</i>, vol. 14, 1643, Springer Nature,
    2023, doi:<a href="https://doi.org/10.1038/s41467-023-37054-2">10.1038/s41467-023-37054-2</a>.
  short: T. Brandstätter, D. Brückner, Y.L. Han, R. Alert, M. Guo, C.P. Broedersz,
    Nature Communications 14 (2023).
date_created: 2023-04-09T22:01:00Z
date_published: 2023-03-24T00:00:00Z
date_updated: 2023-08-01T14:05:30Z
day: '24'
ddc:
- '570'
department:
- _id: EdHa
doi: 10.1038/s41467-023-37054-2
external_id:
  isi:
  - '000959887700008'
  pmid:
  - '36964141'
file:
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  success: 1
file_date_updated: 2023-04-11T06:27:00Z
has_accepted_license: '1'
intvolume: '        14'
isi: 1
language:
- iso: eng
month: '03'
oa: 1
oa_version: Published Version
pmid: 1
publication: Nature Communications
publication_identifier:
  eissn:
  - 2041-1723
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
scopus_import: '1'
status: public
title: Curvature induces active velocity waves in rotating spherical tissues
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 14
year: '2023'
...
---
_id: '12819'
abstract:
- lang: eng
  text: 'Reaching a high cavity population with a coherent pump in the strong-coupling
    regime of a single-atom laser is impossible due to the photon blockade effect.
    In this Letter, we experimentally demonstrate that in a single-atom maser based
    on a transmon strongly coupled to two resonators, it is possible to pump over
    a dozen photons into the system. The first high-quality resonator plays the role
    of a usual lasing cavity, and the second one presents a controlled dissipation
    channel, bolstering population inversion, and modifies the energy-level structure
    to lift the blockade. As confirmation of the lasing action, we observe conventional
    laser features such as a narrowing of the emission linewidth and external signal
    amplification. Additionally, we report unique single-atom features: self-quenching
    and several lasing thresholds.'
acknowledgement: We thank N.N. Abramov for assistance with the experimental setup.
  The sample was fabricated using equipment of MIPT Shared Facilities Center. This
  research was supported by Russian Science Foundation, grant no. 21-72-30026.
article_number: L031701
article_processing_charge: No
article_type: letter_note
arxiv: 1
author:
- first_name: Alesya
  full_name: Sokolova, Alesya
  id: 2d0a0600-edfb-11eb-afb5-c0f5fa7f4f3a
  last_name: Sokolova
  orcid: 0000-0002-8308-4144
- first_name: D. A.
  full_name: Kalacheva, D. A.
  last_name: Kalacheva
- first_name: G. P.
  full_name: Fedorov, G. P.
  last_name: Fedorov
- first_name: O. V.
  full_name: Astafiev, O. V.
  last_name: Astafiev
citation:
  ama: Sokolova A, Kalacheva DA, Fedorov GP, Astafiev OV. Overcoming photon blockade
    in a circuit-QED single-atom maser with engineered metastability and strong coupling.
    <i>Physical Review A</i>. 2023;107(3). doi:<a href="https://doi.org/10.1103/PhysRevA.107.L031701">10.1103/PhysRevA.107.L031701</a>
  apa: Sokolova, A., Kalacheva, D. A., Fedorov, G. P., &#38; Astafiev, O. V. (2023).
    Overcoming photon blockade in a circuit-QED single-atom maser with engineered
    metastability and strong coupling. <i>Physical Review A</i>. American Physical
    Society. <a href="https://doi.org/10.1103/PhysRevA.107.L031701">https://doi.org/10.1103/PhysRevA.107.L031701</a>
  chicago: Sokolova, Alesya, D. A. Kalacheva, G. P. Fedorov, and O. V. Astafiev. “Overcoming
    Photon Blockade in a Circuit-QED Single-Atom Maser with Engineered Metastability
    and Strong Coupling.” <i>Physical Review A</i>. American Physical Society, 2023.
    <a href="https://doi.org/10.1103/PhysRevA.107.L031701">https://doi.org/10.1103/PhysRevA.107.L031701</a>.
  ieee: A. Sokolova, D. A. Kalacheva, G. P. Fedorov, and O. V. Astafiev, “Overcoming
    photon blockade in a circuit-QED single-atom maser with engineered metastability
    and strong coupling,” <i>Physical Review A</i>, vol. 107, no. 3. American Physical
    Society, 2023.
  ista: Sokolova A, Kalacheva DA, Fedorov GP, Astafiev OV. 2023. Overcoming photon
    blockade in a circuit-QED single-atom maser with engineered metastability and
    strong coupling. Physical Review A. 107(3), L031701.
  mla: Sokolova, Alesya, et al. “Overcoming Photon Blockade in a Circuit-QED Single-Atom
    Maser with Engineered Metastability and Strong Coupling.” <i>Physical Review A</i>,
    vol. 107, no. 3, L031701, American Physical Society, 2023, doi:<a href="https://doi.org/10.1103/PhysRevA.107.L031701">10.1103/PhysRevA.107.L031701</a>.
  short: A. Sokolova, D.A. Kalacheva, G.P. Fedorov, O.V. Astafiev, Physical Review
    A 107 (2023).
date_created: 2023-04-09T22:01:00Z
date_published: 2023-03-22T00:00:00Z
date_updated: 2023-08-01T14:06:05Z
day: '22'
department:
- _id: JoFi
doi: 10.1103/PhysRevA.107.L031701
external_id:
  arxiv:
  - '2209.05165'
  isi:
  - '000957799000006'
intvolume: '       107'
isi: 1
issue: '3'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://doi.org/10.48550/arXiv.2209.05165
month: '03'
oa: 1
oa_version: Preprint
publication: Physical Review A
publication_identifier:
  eissn:
  - 2469-9934
  issn:
  - 2469-9926
publication_status: published
publisher: American Physical Society
quality_controlled: '1'
scopus_import: '1'
status: public
title: Overcoming photon blockade in a circuit-QED single-atom maser with engineered
  metastability and strong coupling
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 107
year: '2023'
...
