---
_id: '417'
abstract:
- lang: eng
  text: 'We introduce a Diagrammatic Monte Carlo (DiagMC) approach to complex molecular
    impurities with rotational degrees of freedom interacting with a many-particle
    environment. The treatment is based on the diagrammatic expansion that merges
    the usual Feynman diagrams with the angular momentum diagrams known from atomic
    and nuclear structure theory, thereby incorporating the non-Abelian algebra inherent
    to quantum rotations. Our approach works at arbitrary coupling, is free of systematic
    errors and of finite size effects, and naturally provides access to the impurity
    Green function. We exemplify the technique by obtaining an all-coupling solution
    of the angulon model, however, the method is quite general and can be applied
    to a broad variety of quantum impurities possessing angular momentum degrees of
    freedom. '
article_number: '165301'
article_processing_charge: No
arxiv: 1
author:
- first_name: Giacomo
  full_name: Bighin, Giacomo
  id: 4CA96FD4-F248-11E8-B48F-1D18A9856A87
  last_name: Bighin
  orcid: 0000-0001-8823-9777
- first_name: Timur
  full_name: Tscherbul, Timur
  last_name: Tscherbul
- first_name: Mikhail
  full_name: Lemeshko, Mikhail
  id: 37CB05FA-F248-11E8-B48F-1D18A9856A87
  last_name: Lemeshko
  orcid: 0000-0002-6990-7802
citation:
  ama: Bighin G, Tscherbul T, Lemeshko M. Diagrammatic Monte Carlo approach to rotating
    molecular impurities. <i>Physical Review Letters</i>. 2018;121(16). doi:<a href="https://doi.org/10.1103/PhysRevLett.121.165301">10.1103/PhysRevLett.121.165301</a>
  apa: Bighin, G., Tscherbul, T., &#38; Lemeshko, M. (2018). Diagrammatic Monte Carlo
    approach to rotating molecular impurities. <i>Physical Review Letters</i>. American
    Physical Society. <a href="https://doi.org/10.1103/PhysRevLett.121.165301">https://doi.org/10.1103/PhysRevLett.121.165301</a>
  chicago: Bighin, Giacomo, Timur Tscherbul, and Mikhail Lemeshko. “Diagrammatic Monte
    Carlo Approach to Rotating Molecular Impurities.” <i>Physical Review Letters</i>.
    American Physical Society, 2018. <a href="https://doi.org/10.1103/PhysRevLett.121.165301">https://doi.org/10.1103/PhysRevLett.121.165301</a>.
  ieee: G. Bighin, T. Tscherbul, and M. Lemeshko, “Diagrammatic Monte Carlo approach
    to rotating molecular impurities,” <i>Physical Review Letters</i>, vol. 121, no.
    16. American Physical Society, 2018.
  ista: Bighin G, Tscherbul T, Lemeshko M. 2018. Diagrammatic Monte Carlo approach
    to rotating molecular impurities. Physical Review Letters. 121(16), 165301.
  mla: Bighin, Giacomo, et al. “Diagrammatic Monte Carlo Approach to Rotating Molecular
    Impurities.” <i>Physical Review Letters</i>, vol. 121, no. 16, 165301, American
    Physical Society, 2018, doi:<a href="https://doi.org/10.1103/PhysRevLett.121.165301">10.1103/PhysRevLett.121.165301</a>.
  short: G. Bighin, T. Tscherbul, M. Lemeshko, Physical Review Letters 121 (2018).
date_created: 2018-12-11T11:46:22Z
date_published: 2018-10-16T00:00:00Z
date_updated: 2024-02-28T13:14:53Z
day: '16'
department:
- _id: MiLe
doi: 10.1103/PhysRevLett.121.165301
external_id:
  arxiv:
  - '1803.07990'
intvolume: '       121'
issue: '16'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://arxiv.org/abs/1803.07990
month: '10'
oa: 1
oa_version: Preprint
project:
- _id: 26031614-B435-11E9-9278-68D0E5697425
  call_identifier: FWF
  grant_number: P29902
  name: Quantum rotations in the presence of a many-body environment
publication: Physical Review Letters
publication_status: published
publisher: American Physical Society
publist_id: '8025'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Diagrammatic Monte Carlo approach to rotating molecular impurities
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 121
year: '2018'
...
---
_id: '418'
abstract:
- lang: eng
  text: "The aim of this thesis was the development of new strategies for optical
    and optogenetic control of proliferative and pro-survival signaling, and characterizing
    them from the molecular mechanism up to cellular effects. These new light-based
    methods have unique features, such as red light as an activator, or the avoidance
    of gene delivery, which enable to overcome current limitations, such as light
    delivery to target tissues and feasibility as therapeutic approach. A special
    focus was placed on implementing these new light-based approaches in pancreatic
    β-cells, as β-cells are the key players in diabetes and especially their loss
    in number negatively affects disease progression. Currently no treatment options
    are available to compensate the lack of functional β-cells in diabetic patients.\r\nIn
    a first approach, red-light-activated growth factor receptors, in particular receptor
    tyrosine kinases were engineered and characterized. Receptor activation with light
    allows spatio-temporal control compared to ligand-based activation, and especially
    red light exhibits deeper tissue penetration than other wavelengths of the visible
    spectrum. Red-light-activated receptor tyrosine kinases robustly activated major
    growth factor related signaling pathways with a high temporal resolution. Moreover,
    the remote activation of the proliferative MAPK/Erk pathway by red-light-activated
    receptor tyrosine kinases in a pancreatic β-cell line was also achieved, through
    one centimeter thick mouse tissue. Although red-light-activated receptor tyrosine
    kinases are particularly attractive for applications in animal models due to the
    deep tissue penetration of red light, a drawback, especially with regard to translation
    into humans, is the requirement of gene therapy.\r\nIn a second approach an endogenous
    light-sensitive mechanism was identified and its potential to promote proliferative
    and pro-survival signals was explored, towards light-based tissue regeneration
    without the need for gene transfer. Blue-green light illumination was found to
    be sufficient for the activation of proliferation and survival promoting signaling
    pathways in primary pancreatic murine and human islets. Blue-green light also
    led to an increase in proliferation of primary islet cells, an effect which was
    shown to be mostly β-cell specific in human islets. Moreover, it was demonstrated
    that this approach of pancreatic β-cell expansion did not have any negative effect
    on the β-cell function, in particular on their insulin secretion capacity. In
    contrast, a trend for enhanced insulin secretion under high glucose conditions
    after illumination was detected. In order to unravel the detailed characteristics
    of this endogenous light-sensitive mechanism, the precise light requirements were
    determined. In addition, the expression of light sensing proteins, OPN3 and rhodopsin,
    was detected. The observed effects were found to be independent of handling effects
    such as temperature differences and cytochrome c oxidase dependent ATP increase,
    but they were found to be enhanced through the knockout of OPN3. The exact mechanism
    of how islets cells sense light and the identity of the photoreceptor remains
    unknown.\r\nSummarized two new light-based systems with unique features were established
    that enable the activation of proliferative and pro-survival signaling pathways.
    While red-light-activated receptor tyrosine kinases open a new avenue for optogenetics
    research, by allowing non-invasive control of signaling in vivo, the identified
    endogenous light-sensitive mechanism has the potential to be the basis of a gene
    therapy-free therapeutical approach for light-based β-cell expansion."
alternative_title:
- ISTA Thesis
article_processing_charge: No
author:
- first_name: Eva
  full_name: Gschaider-Reichhart, Eva
  id: 3FEE232A-F248-11E8-B48F-1D18A9856A87
  last_name: Gschaider-Reichhart
  orcid: 0000-0002-7218-7738
citation:
  ama: Gschaider-Reichhart E. Optical and optogenetic control of proliferation and
    survival . 2018. doi:<a href="https://doi.org/10.15479/AT:ISTA:th_913">10.15479/AT:ISTA:th_913</a>
  apa: Gschaider-Reichhart, E. (2018). <i>Optical and optogenetic control of proliferation
    and survival </i>. Institute of Science and Technology Austria. <a href="https://doi.org/10.15479/AT:ISTA:th_913">https://doi.org/10.15479/AT:ISTA:th_913</a>
  chicago: Gschaider-Reichhart, Eva. “Optical and Optogenetic Control of Proliferation
    and Survival .” Institute of Science and Technology Austria, 2018. <a href="https://doi.org/10.15479/AT:ISTA:th_913">https://doi.org/10.15479/AT:ISTA:th_913</a>.
  ieee: E. Gschaider-Reichhart, “Optical and optogenetic control of proliferation
    and survival ,” Institute of Science and Technology Austria, 2018.
  ista: Gschaider-Reichhart E. 2018. Optical and optogenetic control of proliferation
    and survival . Institute of Science and Technology Austria.
  mla: Gschaider-Reichhart, Eva. <i>Optical and Optogenetic Control of Proliferation
    and Survival </i>. Institute of Science and Technology Austria, 2018, doi:<a href="https://doi.org/10.15479/AT:ISTA:th_913">10.15479/AT:ISTA:th_913</a>.
  short: E. Gschaider-Reichhart, Optical and Optogenetic Control of Proliferation
    and Survival , Institute of Science and Technology Austria, 2018.
date_created: 2018-12-11T11:46:22Z
date_published: 2018-01-08T00:00:00Z
date_updated: 2023-09-22T09:20:10Z
day: '08'
ddc:
- '571'
- '570'
degree_awarded: PhD
department:
- _id: HaJa
doi: 10.15479/AT:ISTA:th_913
file:
- access_level: closed
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  date_created: 2019-04-05T09:28:03Z
  date_updated: 2020-07-14T12:46:24Z
  file_id: '6222'
  file_name: 2018_THESIS_Gschaider-Reichhart_source.docx
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file_date_updated: 2020-07-14T12:46:24Z
has_accepted_license: '1'
language:
- iso: eng
month: '01'
oa: 1
oa_version: Published Version
page: '107'
publication_identifier:
  issn:
  - 2663-337X
publication_status: published
publisher: Institute of Science and Technology Austria
publist_id: '7405'
pubrep_id: '913'
related_material:
  record:
  - id: '1441'
    relation: part_of_dissertation
    status: public
  - id: '1678'
    relation: part_of_dissertation
    status: public
  - id: '2084'
    relation: part_of_dissertation
    status: public
  - id: '1028'
    relation: part_of_dissertation
    status: public
status: public
supervisor:
- first_name: Harald L
  full_name: Janovjak, Harald L
  id: 33BA6C30-F248-11E8-B48F-1D18A9856A87
  last_name: Janovjak
  orcid: 0000-0002-8023-9315
title: 'Optical and optogenetic control of proliferation and survival '
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: dissertation
user_id: c635000d-4b10-11ee-a964-aac5a93f6ac1
year: '2018'
...
---
_id: '419'
abstract:
- lang: eng
  text: 'Reciprocity is a major factor in human social life and accounts for a large
    part of cooperation in our communities. Direct reciprocity arises when repeated
    interactions occur between the same individuals. The framework of iterated games
    formalizes this phenomenon. Despite being introduced more than five decades ago,
    the concept keeps offering beautiful surprises. Recent theoretical research driven
    by new mathematical tools has proposed a remarkable dichotomy among the crucial
    strategies: successful individuals either act as partners or as rivals. Rivals
    strive for unilateral advantages by applying selfish or extortionate strategies.
    Partners aim to share the payoff for mutual cooperation, but are ready to fight
    back when being exploited. Which of these behaviours evolves depends on the environment.
    Whereas small population sizes and a limited number of rounds favour rivalry,
    partner strategies are selected when populations are large and relationships stable.
    Only partners allow for evolution of cooperation, while the rivals’ attempt to
    put themselves first leads to defection. Hilbe et al. synthesize recent theoretical
    work on zero-determinant and ‘rival’ versus ‘partner’ strategies in social dilemmas.
    They describe the environments under which these contrasting selfish or cooperative
    strategies emerge in evolution.'
article_processing_charge: No
article_type: review
author:
- first_name: Christian
  full_name: Hilbe, Christian
  id: 2FDF8F3C-F248-11E8-B48F-1D18A9856A87
  last_name: Hilbe
  orcid: 0000-0001-5116-955X
- first_name: Krishnendu
  full_name: Chatterjee, Krishnendu
  id: 2E5DCA20-F248-11E8-B48F-1D18A9856A87
  last_name: Chatterjee
  orcid: 0000-0002-4561-241X
- first_name: Martin
  full_name: Nowak, Martin
  last_name: Nowak
citation:
  ama: Hilbe C, Chatterjee K, Nowak M. Partners and rivals in direct reciprocity.
    <i>Nature Human Behaviour</i>. 2018;2:469–477. doi:<a href="https://doi.org/10.1038/s41562-018-0320-9">10.1038/s41562-018-0320-9</a>
  apa: Hilbe, C., Chatterjee, K., &#38; Nowak, M. (2018). Partners and rivals in direct
    reciprocity. <i>Nature Human Behaviour</i>. Nature Publishing Group. <a href="https://doi.org/10.1038/s41562-018-0320-9">https://doi.org/10.1038/s41562-018-0320-9</a>
  chicago: Hilbe, Christian, Krishnendu Chatterjee, and Martin Nowak. “Partners and
    Rivals in Direct Reciprocity.” <i>Nature Human Behaviour</i>. Nature Publishing
    Group, 2018. <a href="https://doi.org/10.1038/s41562-018-0320-9">https://doi.org/10.1038/s41562-018-0320-9</a>.
  ieee: C. Hilbe, K. Chatterjee, and M. Nowak, “Partners and rivals in direct reciprocity,”
    <i>Nature Human Behaviour</i>, vol. 2. Nature Publishing Group, pp. 469–477, 2018.
  ista: Hilbe C, Chatterjee K, Nowak M. 2018. Partners and rivals in direct reciprocity.
    Nature Human Behaviour. 2, 469–477.
  mla: Hilbe, Christian, et al. “Partners and Rivals in Direct Reciprocity.” <i>Nature
    Human Behaviour</i>, vol. 2, Nature Publishing Group, 2018, pp. 469–477, doi:<a
    href="https://doi.org/10.1038/s41562-018-0320-9">10.1038/s41562-018-0320-9</a>.
  short: C. Hilbe, K. Chatterjee, M. Nowak, Nature Human Behaviour 2 (2018) 469–477.
date_created: 2018-12-11T11:46:22Z
date_published: 2018-03-19T00:00:00Z
date_updated: 2023-09-13T09:38:54Z
day: '19'
ddc:
- '000'
department:
- _id: KrCh
doi: 10.1038/s41562-018-0320-9
ec_funded: 1
external_id:
  isi:
  - '000446612000016'
file:
- access_level: open_access
  checksum: 571b8cc0ba14e8d5d8b18e439a9835eb
  content_type: application/pdf
  creator: dernst
  date_created: 2019-11-19T08:19:51Z
  date_updated: 2020-07-14T12:46:25Z
  file_id: '7052'
  file_name: 2018_NatureHumanBeh_Hilbe.pdf
  file_size: 598033
  relation: main_file
file_date_updated: 2020-07-14T12:46:25Z
has_accepted_license: '1'
intvolume: '         2'
isi: 1
language:
- iso: eng
month: '03'
oa: 1
oa_version: Submitted Version
page: 469–477
project:
- _id: 2581B60A-B435-11E9-9278-68D0E5697425
  call_identifier: FP7
  grant_number: '279307'
  name: 'Quantitative Graph Games: Theory and Applications'
- _id: 2584A770-B435-11E9-9278-68D0E5697425
  call_identifier: FWF
  grant_number: P 23499-N23
  name: Modern Graph Algorithmic Techniques in Formal Verification
- _id: 25832EC2-B435-11E9-9278-68D0E5697425
  call_identifier: FWF
  grant_number: S 11407_N23
  name: Rigorous Systems Engineering
- _id: 25681D80-B435-11E9-9278-68D0E5697425
  call_identifier: FP7
  grant_number: '291734'
  name: International IST Postdoc Fellowship Programme
publication: Nature Human Behaviour
publication_status: published
publisher: Nature Publishing Group
publist_id: '7404'
quality_controlled: '1'
related_material:
  link:
  - relation: erratum
    url: http://doi.org/10.1038/s41562-018-0342-3
scopus_import: '1'
status: public
title: Partners and rivals in direct reciprocity
type: journal_article
user_id: c635000d-4b10-11ee-a964-aac5a93f6ac1
volume: 2
year: '2018'
...
---
_id: '42'
abstract:
- lang: eng
  text: Seeds derive from ovules upon fertilization and therefore the total number
    of ovules determines the final seed yield, a fundamental trait in crop plants.
    Among the factors that co-ordinate the process of ovule formation, the transcription
    factors CUP-SHAPED COTYLEDON 1 (CUC1) and CUC2 and the hormone cytokinin (CK)
    have a particularly prominent role. Indeed, the absence of both CUC1 and CUC2
    causes a severe reduction in ovule number, a phenotype that can be rescued by
    CK treatment. In this study, we combined CK quantification with an integrative
    genome-wide target identification approach to select Arabidopsis genes regulated
    by CUCs that are also involved in CK metabolism. We focused our attention on the
    functional characterization of UDP-GLUCOSYL TRANSFERASE 85A3 (UGT85A3) and UGT73C1,
    which are up-regulated in the absence of CUC1 and CUC2 and encode enzymes able
    to catalyse CK inactivation by O-glucosylation. Our results demonstrate a role
    for these UGTs as a link between CUCs and CK homeostasis, and highlight the importance
    of CUCs and CKs in the determination of seed yield.
acknowledgement: This work was funded by the Ministry of Education, Youth and Sports
  of the Czech Republic through the National Program of Sustainability (grant no.
  LO1204).
article_processing_charge: No
author:
- first_name: Mara
  full_name: Cucinotta, Mara
  last_name: Cucinotta
- first_name: Silvia
  full_name: Manrique, Silvia
  last_name: Manrique
- first_name: Candela
  full_name: Cuesta, Candela
  id: 33A3C818-F248-11E8-B48F-1D18A9856A87
  last_name: Cuesta
  orcid: 0000-0003-1923-2410
- first_name: Eva
  full_name: Benková, Eva
  id: 38F4F166-F248-11E8-B48F-1D18A9856A87
  last_name: Benková
  orcid: 0000-0002-8510-9739
- first_name: Ondřej
  full_name: Novák, Ondřej
  last_name: Novák
- first_name: Lucia
  full_name: Colombo, Lucia
  last_name: Colombo
citation:
  ama: Cucinotta M, Manrique S, Cuesta C, Benková E, Novák O, Colombo L. Cup-shaped
    Cotyledon1 (CUC1) and CU2 regulate cytokinin homeostasis to determine ovule number
    in arabidopsis. <i>Journal of Experimental Botany</i>. 2018;69(21):5169-5176.
    doi:<a href="https://doi.org/10.1093/jxb/ery281">10.1093/jxb/ery281</a>
  apa: Cucinotta, M., Manrique, S., Cuesta, C., Benková, E., Novák, O., &#38; Colombo,
    L. (2018). Cup-shaped Cotyledon1 (CUC1) and CU2 regulate cytokinin homeostasis
    to determine ovule number in arabidopsis. <i>Journal of Experimental Botany</i>.
    Oxford University Press. <a href="https://doi.org/10.1093/jxb/ery281">https://doi.org/10.1093/jxb/ery281</a>
  chicago: Cucinotta, Mara, Silvia Manrique, Candela Cuesta, Eva Benková, Ondřej Novák,
    and Lucia Colombo. “Cup-Shaped Cotyledon1 (CUC1) and CU2 Regulate Cytokinin Homeostasis
    to Determine Ovule Number in Arabidopsis.” <i>Journal of Experimental Botany</i>.
    Oxford University Press, 2018. <a href="https://doi.org/10.1093/jxb/ery281">https://doi.org/10.1093/jxb/ery281</a>.
  ieee: M. Cucinotta, S. Manrique, C. Cuesta, E. Benková, O. Novák, and L. Colombo,
    “Cup-shaped Cotyledon1 (CUC1) and CU2 regulate cytokinin homeostasis to determine
    ovule number in arabidopsis,” <i>Journal of Experimental Botany</i>, vol. 69,
    no. 21. Oxford University Press, pp. 5169–5176, 2018.
  ista: Cucinotta M, Manrique S, Cuesta C, Benková E, Novák O, Colombo L. 2018. Cup-shaped
    Cotyledon1 (CUC1) and CU2 regulate cytokinin homeostasis to determine ovule number
    in arabidopsis. Journal of Experimental Botany. 69(21), 5169–5176.
  mla: Cucinotta, Mara, et al. “Cup-Shaped Cotyledon1 (CUC1) and CU2 Regulate Cytokinin
    Homeostasis to Determine Ovule Number in Arabidopsis.” <i>Journal of Experimental
    Botany</i>, vol. 69, no. 21, Oxford University Press, 2018, pp. 5169–76, doi:<a
    href="https://doi.org/10.1093/jxb/ery281">10.1093/jxb/ery281</a>.
  short: M. Cucinotta, S. Manrique, C. Cuesta, E. Benková, O. Novák, L. Colombo, Journal
    of Experimental Botany 69 (2018) 5169–5176.
date_created: 2018-12-11T11:44:19Z
date_published: 2018-07-26T00:00:00Z
date_updated: 2023-09-11T12:52:03Z
day: '26'
ddc:
- '575'
department:
- _id: EvBe
doi: 10.1093/jxb/ery281
external_id:
  isi:
  - '000448163900015'
file:
- access_level: open_access
  checksum: ca3b6711040b1662488aeb3d1f961f13
  content_type: application/pdf
  creator: dernst
  date_created: 2018-12-17T10:44:16Z
  date_updated: 2020-07-14T12:46:25Z
  file_id: '5691'
  file_name: 2018_JournalExperimBotany_Cucinotta.pdf
  file_size: 1292128
  relation: main_file
file_date_updated: 2020-07-14T12:46:25Z
has_accepted_license: '1'
intvolume: '        69'
isi: 1
issue: '21'
language:
- iso: eng
month: '07'
oa: 1
oa_version: Published Version
page: 5169 - 5176
publication: Journal of Experimental Botany
publication_status: published
publisher: Oxford University Press
publist_id: '8012'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Cup-shaped Cotyledon1 (CUC1) and CU2 regulate cytokinin homeostasis to determine
  ovule number in arabidopsis
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: c635000d-4b10-11ee-a964-aac5a93f6ac1
volume: 69
year: '2018'
...
---
_id: '420'
abstract:
- lang: eng
  text: We analyze the theoretical derivation of the beyond-mean-field equation of
    state for two-dimensional gas of dilute, ultracold alkali-metal atoms in the Bardeen–Cooper–Schrieffer
    (BCS) to Bose–Einstein condensate (BEC) crossover. We show that at zero temperature
    our theory — considering Gaussian fluctuations on top of the mean-field equation
    of state — is in very good agreement with experimental data. Subsequently, we
    investigate the superfluid density at finite temperature and its renormalization
    due to the proliferation of vortex–antivortex pairs. By doing so, we determine
    the Berezinskii–Kosterlitz–Thouless (BKT) critical temperature — at which the
    renormalized superfluid density jumps to zero — as a function of the inter-atomic
    potential strength. We find that the Nelson–Kosterlitz criterion overestimates
    the BKT temperature with respect to the renormalization group equations, this
    effect being particularly relevant in the intermediate regime of the crossover.
article_processing_charge: No
author:
- first_name: Giacomo
  full_name: Bighin, Giacomo
  id: 4CA96FD4-F248-11E8-B48F-1D18A9856A87
  last_name: Bighin
  orcid: 0000-0001-8823-9777
- first_name: Luca
  full_name: Salasnich, Luca
  last_name: Salasnich
citation:
  ama: Bighin G, Salasnich L. Renormalization of the superfluid density in the two-dimensional
    BCS-BEC crossover. <i>International Journal of Modern Physics B</i>. 2018;32(17):1840022.
    doi:<a href="https://doi.org/10.1142/S0217979218400222">10.1142/S0217979218400222</a>
  apa: Bighin, G., &#38; Salasnich, L. (2018). Renormalization of the superfluid density
    in the two-dimensional BCS-BEC crossover. <i>International Journal of Modern Physics
    B</i>. World Scientific Publishing. <a href="https://doi.org/10.1142/S0217979218400222">https://doi.org/10.1142/S0217979218400222</a>
  chicago: Bighin, Giacomo, and Luca Salasnich. “Renormalization of the Superfluid
    Density in the Two-Dimensional BCS-BEC Crossover.” <i>International Journal of
    Modern Physics B</i>. World Scientific Publishing, 2018. <a href="https://doi.org/10.1142/S0217979218400222">https://doi.org/10.1142/S0217979218400222</a>.
  ieee: G. Bighin and L. Salasnich, “Renormalization of the superfluid density in
    the two-dimensional BCS-BEC crossover,” <i>International Journal of Modern Physics
    B</i>, vol. 32, no. 17. World Scientific Publishing, p. 1840022, 2018.
  ista: Bighin G, Salasnich L. 2018. Renormalization of the superfluid density in
    the two-dimensional BCS-BEC crossover. International Journal of Modern Physics
    B. 32(17), 1840022.
  mla: Bighin, Giacomo, and Luca Salasnich. “Renormalization of the Superfluid Density
    in the Two-Dimensional BCS-BEC Crossover.” <i>International Journal of Modern
    Physics B</i>, vol. 32, no. 17, World Scientific Publishing, 2018, p. 1840022,
    doi:<a href="https://doi.org/10.1142/S0217979218400222">10.1142/S0217979218400222</a>.
  short: G. Bighin, L. Salasnich, International Journal of Modern Physics B 32 (2018)
    1840022.
date_created: 2018-12-11T11:46:22Z
date_published: 2018-07-10T00:00:00Z
date_updated: 2023-09-18T08:09:59Z
day: '10'
department:
- _id: MiLe
doi: 10.1142/S0217979218400222
external_id:
  isi:
  - '000438217300007'
intvolume: '        32'
isi: 1
issue: '17'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://arxiv.org/abs/1710.11171
month: '07'
oa: 1
oa_version: Preprint
page: '1840022'
publication: International Journal of Modern Physics B
publication_status: published
publisher: World Scientific Publishing
publist_id: '7402'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Renormalization of the superfluid density in the two-dimensional BCS-BEC crossover
type: journal_article
user_id: c635000d-4b10-11ee-a964-aac5a93f6ac1
volume: 32
year: '2018'
...
---
_id: '421'
abstract:
- lang: eng
  text: Cell shape is determined by a balance of intrinsic properties of the cell
    as well as its mechanochemical environment. Inhomogeneous shape changes underlie
    many morphogenetic events and involve spatial gradients in active cellular forces
    induced by complex chemical signaling. Here, we introduce a mechanochemical model
    based on the notion that cell shape changes may be induced by external diffusible
    biomolecules that influence cellular contractility (or equivalently, adhesions)
    in a concentration-dependent manner—and whose spatial profile in turn is affected
    by cell shape. We map out theoretically the possible interplay between chemical
    concentration and cellular structure. Besides providing a direct route to spatial
    gradients in cell shape profiles in tissues, we show that the dependence on cell
    shape helps create robust mechanochemical gradients.
article_processing_charge: No
arxiv: 1
author:
- first_name: Kinjal
  full_name: Dasbiswas, Kinjal
  last_name: Dasbiswas
- first_name: Claude-Edouard B
  full_name: Hannezo, Claude-Edouard B
  id: 3A9DB764-F248-11E8-B48F-1D18A9856A87
  last_name: Hannezo
  orcid: 0000-0001-6005-1561
- first_name: Nir
  full_name: Gov, Nir
  last_name: Gov
citation:
  ama: Dasbiswas K, Hannezo EB, Gov N. Theory of eppithelial cell shape transitions
    induced by mechanoactive chemical gradients. <i>Biophysical Journal</i>. 2018;114(4):968-977.
    doi:<a href="https://doi.org/10.1016/j.bpj.2017.12.022">10.1016/j.bpj.2017.12.022</a>
  apa: Dasbiswas, K., Hannezo, E. B., &#38; Gov, N. (2018). Theory of eppithelial
    cell shape transitions induced by mechanoactive chemical gradients. <i>Biophysical
    Journal</i>. Biophysical Society. <a href="https://doi.org/10.1016/j.bpj.2017.12.022">https://doi.org/10.1016/j.bpj.2017.12.022</a>
  chicago: Dasbiswas, Kinjal, Edouard B Hannezo, and Nir Gov. “Theory of Eppithelial
    Cell Shape Transitions Induced by Mechanoactive Chemical Gradients.” <i>Biophysical
    Journal</i>. Biophysical Society, 2018. <a href="https://doi.org/10.1016/j.bpj.2017.12.022">https://doi.org/10.1016/j.bpj.2017.12.022</a>.
  ieee: K. Dasbiswas, E. B. Hannezo, and N. Gov, “Theory of eppithelial cell shape
    transitions induced by mechanoactive chemical gradients,” <i>Biophysical Journal</i>,
    vol. 114, no. 4. Biophysical Society, pp. 968–977, 2018.
  ista: Dasbiswas K, Hannezo EB, Gov N. 2018. Theory of eppithelial cell shape transitions
    induced by mechanoactive chemical gradients. Biophysical Journal. 114(4), 968–977.
  mla: Dasbiswas, Kinjal, et al. “Theory of Eppithelial Cell Shape Transitions Induced
    by Mechanoactive Chemical Gradients.” <i>Biophysical Journal</i>, vol. 114, no.
    4, Biophysical Society, 2018, pp. 968–77, doi:<a href="https://doi.org/10.1016/j.bpj.2017.12.022">10.1016/j.bpj.2017.12.022</a>.
  short: K. Dasbiswas, E.B. Hannezo, N. Gov, Biophysical Journal 114 (2018) 968–977.
date_created: 2018-12-11T11:46:23Z
date_published: 2018-02-27T00:00:00Z
date_updated: 2023-09-19T10:13:55Z
day: '27'
department:
- _id: EdHa
doi: 10.1016/j.bpj.2017.12.022
external_id:
  arxiv:
  - '1709.01486'
  isi:
  - '000428016700021'
intvolume: '       114'
isi: 1
issue: '4'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://arxiv.org/abs/1709.01486
month: '02'
oa: 1
oa_version: Submitted Version
page: 968 - 977
publication: Biophysical Journal
publication_status: published
publisher: Biophysical Society
publist_id: '7403'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Theory of eppithelial cell shape transitions induced by mechanoactive chemical
  gradients
type: journal_article
user_id: c635000d-4b10-11ee-a964-aac5a93f6ac1
volume: 114
year: '2018'
...
---
_id: '422'
abstract:
- lang: eng
  text: We show that a rather simple, steady modification of the streamwise velocity
    profile in a pipe can lead to a complete collapse of turbulence and the flow fully
    relaminarizes. Two different devices, a stationary obstacle (inset) and a device
    which injects fluid through an annular gap close to the wall, are used to control
    the flow. Both devices modify the streamwise velocity profile such that the flow
    in the center of the pipe is decelerated and the flow in the near wall region
    is accelerated. We present measurements with stereoscopic particle image velocimetry
    to investigate and capture the development of the relaminarizing flow downstream
    these devices and the specific circumstances responsible for relaminarization.
    We find total relaminarization up to Reynolds numbers of 6000, where the skin
    friction in the far downstream distance is reduced by a factor of 3.4 due to relaminarization.
    In a smooth straight pipe the flow remains completely laminar downstream of the
    control. Furthermore, we show that transient (temporary) relaminarization in a
    spatially confined region right downstream the devices occurs also at much higher
    Reynolds numbers, accompanied by a significant local skin friction drag reduction.
    The underlying physical mechanism of relaminarization is attributed to a weakening
    of the near-wall turbulence production cycle.
article_processing_charge: Yes (via OA deal)
author:
- first_name: Jakob
  full_name: Kühnen, Jakob
  id: 3A47AE32-F248-11E8-B48F-1D18A9856A87
  last_name: Kühnen
  orcid: 0000-0003-4312-0179
- first_name: Davide
  full_name: Scarselli, Davide
  id: 40315C30-F248-11E8-B48F-1D18A9856A87
  last_name: Scarselli
  orcid: 0000-0001-5227-4271
- first_name: Markus
  full_name: Schaner, Markus
  id: 316CE034-F248-11E8-B48F-1D18A9856A87
  last_name: Schaner
- first_name: Björn
  full_name: Hof, Björn
  id: 3A374330-F248-11E8-B48F-1D18A9856A87
  last_name: Hof
  orcid: 0000-0003-2057-2754
citation:
  ama: Kühnen J, Scarselli D, Schaner M, Hof B. Relaminarization by steady modification
    of the streamwise velocity profile in a pipe. <i>Flow Turbulence and Combustion</i>.
    2018;100(4):919-942. doi:<a href="https://doi.org/10.1007/s10494-018-9896-4">10.1007/s10494-018-9896-4</a>
  apa: Kühnen, J., Scarselli, D., Schaner, M., &#38; Hof, B. (2018). Relaminarization
    by steady modification of the streamwise velocity profile in a pipe. <i>Flow Turbulence
    and Combustion</i>. Springer. <a href="https://doi.org/10.1007/s10494-018-9896-4">https://doi.org/10.1007/s10494-018-9896-4</a>
  chicago: Kühnen, Jakob, Davide Scarselli, Markus Schaner, and Björn Hof. “Relaminarization
    by Steady Modification of the Streamwise Velocity Profile in a Pipe.” <i>Flow
    Turbulence and Combustion</i>. Springer, 2018. <a href="https://doi.org/10.1007/s10494-018-9896-4">https://doi.org/10.1007/s10494-018-9896-4</a>.
  ieee: J. Kühnen, D. Scarselli, M. Schaner, and B. Hof, “Relaminarization by steady
    modification of the streamwise velocity profile in a pipe,” <i>Flow Turbulence
    and Combustion</i>, vol. 100, no. 4. Springer, pp. 919–942, 2018.
  ista: Kühnen J, Scarselli D, Schaner M, Hof B. 2018. Relaminarization by steady
    modification of the streamwise velocity profile in a pipe. Flow Turbulence and
    Combustion. 100(4), 919–942.
  mla: Kühnen, Jakob, et al. “Relaminarization by Steady Modification of the Streamwise
    Velocity Profile in a Pipe.” <i>Flow Turbulence and Combustion</i>, vol. 100,
    no. 4, Springer, 2018, pp. 919–42, doi:<a href="https://doi.org/10.1007/s10494-018-9896-4">10.1007/s10494-018-9896-4</a>.
  short: J. Kühnen, D. Scarselli, M. Schaner, B. Hof, Flow Turbulence and Combustion
    100 (2018) 919–942.
date_created: 2018-12-11T11:46:23Z
date_published: 2018-01-01T00:00:00Z
date_updated: 2024-03-25T23:30:20Z
day: '01'
ddc:
- '530'
department:
- _id: BjHo
doi: 10.1007/s10494-018-9896-4
ec_funded: 1
external_id:
  isi:
  - '000433113900004'
file:
- access_level: open_access
  checksum: d7c0bade150faabca150b0a9986e60ca
  content_type: application/pdf
  creator: dernst
  date_created: 2018-12-17T15:52:37Z
  date_updated: 2020-07-14T12:46:25Z
  file_id: '5717'
  file_name: 2018_FlowTurbulenceCombust_Kuehnen.pdf
  file_size: 2210020
  relation: main_file
file_date_updated: 2020-07-14T12:46:25Z
has_accepted_license: '1'
intvolume: '       100'
isi: 1
issue: '4'
language:
- iso: eng
month: '01'
oa: 1
oa_version: Published Version
page: 919 - 942
project:
- _id: 25152F3A-B435-11E9-9278-68D0E5697425
  call_identifier: FP7
  grant_number: '306589'
  name: Decoding the complexity of turbulence at its origin
publication: Flow Turbulence and Combustion
publication_status: published
publisher: Springer
publist_id: '7401'
quality_controlled: '1'
related_material:
  record:
  - id: '7258'
    relation: dissertation_contains
    status: public
scopus_import: '1'
status: public
title: Relaminarization by steady modification of the streamwise velocity profile
  in a pipe
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: c635000d-4b10-11ee-a964-aac5a93f6ac1
volume: 100
year: '2018'
...
---
_id: '423'
abstract:
- lang: eng
  text: Herd immunity, a process in which resistant individuals limit the spread of
    a pathogen among susceptible hosts has been extensively studied in eukaryotes.
    Even though bacteria have evolved multiple immune systems against their phage
    pathogens, herd immunity in bacteria remains unexplored. Here we experimentally
    demonstrate that herd immunity arises during phage epidemics in structured and
    unstructured Escherichia coli populations consisting of differing frequencies
    of susceptible and resistant cells harboring CRISPR immunity. In addition, we
    develop a mathematical model that quantifies how herd immunity is affected by
    spatial population structure, bacterial growth rate, and phage replication rate.
    Using our model we infer a general epidemiological rule describing the relative
    speed of an epidemic in partially resistant spatially structured populations.
    Our experimental and theoretical findings indicate that herd immunity may be important
    in bacterial communities, allowing for stable coexistence of bacteria and their
    phages and the maintenance of polymorphism in bacterial immunity.
acknowledgement: "We are grateful to Remy Chait for his help and assistance with establishing
  our experimental setups and to Tobias Bergmiller for valuable insights into some
  specific experimental details. We thank Luciano Marraffini for donating us the pCas9
  plasmid used in this study. We also want to express our gratitude to Seth Barribeau,
  Andrea Betancourt, Călin Guet, Mato Lagator, Tiago Paixão and Maroš Pleška for valuable
  discussions on the manuscript. Finally, we would like to thank the \r\neditors and
  reviewers for their helpful comments and suggestions."
article_number: e32035
article_processing_charge: No
author:
- first_name: Pavel
  full_name: Payne, Pavel
  id: 35F78294-F248-11E8-B48F-1D18A9856A87
  last_name: Payne
  orcid: 0000-0002-2711-9453
- first_name: Lukas
  full_name: Geyrhofer, Lukas
  last_name: Geyrhofer
- first_name: Nicholas H
  full_name: Barton, Nicholas H
  id: 4880FE40-F248-11E8-B48F-1D18A9856A87
  last_name: Barton
  orcid: 0000-0002-8548-5240
- first_name: Jonathan P
  full_name: Bollback, Jonathan P
  id: 2C6FA9CC-F248-11E8-B48F-1D18A9856A87
  last_name: Bollback
  orcid: 0000-0002-4624-4612
citation:
  ama: Payne P, Geyrhofer L, Barton NH, Bollback JP. CRISPR-based herd immunity can
    limit phage epidemics in bacterial populations. <i>eLife</i>. 2018;7. doi:<a href="https://doi.org/10.7554/eLife.32035">10.7554/eLife.32035</a>
  apa: Payne, P., Geyrhofer, L., Barton, N. H., &#38; Bollback, J. P. (2018). CRISPR-based
    herd immunity can limit phage epidemics in bacterial populations. <i>ELife</i>.
    eLife Sciences Publications. <a href="https://doi.org/10.7554/eLife.32035">https://doi.org/10.7554/eLife.32035</a>
  chicago: Payne, Pavel, Lukas Geyrhofer, Nicholas H Barton, and Jonathan P Bollback.
    “CRISPR-Based Herd Immunity Can Limit Phage Epidemics in Bacterial Populations.”
    <i>ELife</i>. eLife Sciences Publications, 2018. <a href="https://doi.org/10.7554/eLife.32035">https://doi.org/10.7554/eLife.32035</a>.
  ieee: P. Payne, L. Geyrhofer, N. H. Barton, and J. P. Bollback, “CRISPR-based herd
    immunity can limit phage epidemics in bacterial populations,” <i>eLife</i>, vol.
    7. eLife Sciences Publications, 2018.
  ista: Payne P, Geyrhofer L, Barton NH, Bollback JP. 2018. CRISPR-based herd immunity
    can limit phage epidemics in bacterial populations. eLife. 7, e32035.
  mla: Payne, Pavel, et al. “CRISPR-Based Herd Immunity Can Limit Phage Epidemics
    in Bacterial Populations.” <i>ELife</i>, vol. 7, e32035, eLife Sciences Publications,
    2018, doi:<a href="https://doi.org/10.7554/eLife.32035">10.7554/eLife.32035</a>.
  short: P. Payne, L. Geyrhofer, N.H. Barton, J.P. Bollback, ELife 7 (2018).
date_created: 2018-12-11T11:46:23Z
date_published: 2018-03-09T00:00:00Z
date_updated: 2023-09-11T12:49:17Z
day: '09'
ddc:
- '576'
department:
- _id: NiBa
- _id: JoBo
doi: 10.7554/eLife.32035
ec_funded: 1
external_id:
  isi:
  - '000431035800001'
file:
- access_level: open_access
  checksum: 447cf6e680bdc3c01062a8737d876569
  content_type: application/pdf
  creator: dernst
  date_created: 2018-12-17T10:36:07Z
  date_updated: 2020-07-14T12:46:25Z
  file_id: '5689'
  file_name: 2018_eLife_Payne.pdf
  file_size: 3533881
  relation: main_file
file_date_updated: 2020-07-14T12:46:25Z
has_accepted_license: '1'
intvolume: '         7'
isi: 1
language:
- iso: eng
month: '03'
oa: 1
oa_version: Published Version
project:
- _id: 2578D616-B435-11E9-9278-68D0E5697425
  call_identifier: H2020
  grant_number: '648440'
  name: Selective Barriers to Horizontal Gene Transfer
publication: eLife
publication_status: published
publisher: eLife Sciences Publications
publist_id: '7400'
quality_controlled: '1'
related_material:
  record:
  - id: '9840'
    relation: research_data
    status: public
scopus_import: '1'
status: public
title: CRISPR-based herd immunity can limit phage epidemics in bacterial populations
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: c635000d-4b10-11ee-a964-aac5a93f6ac1
volume: 7
year: '2018'
...
---
_id: '425'
abstract:
- lang: eng
  text: 'We show that the following algorithmic problem is decidable: given a 2-dimensional
    simplicial complex, can it be embedded (topologically, or equivalently, piecewise
    linearly) in R3? By a known reduction, it suffices to decide the embeddability
    of a given triangulated 3-manifold X into the 3-sphere S3. The main step, which
    allows us to simplify X and recurse, is in proving that if X can be embedded in
    S3, then there is also an embedding in which X has a short meridian, that is,
    an essential curve in the boundary of X bounding a disk in S3 \ X with length
    bounded by a computable function of the number of tetrahedra of X.'
article_number: '5'
article_processing_charge: No
article_type: original
arxiv: 1
author:
- first_name: Jiří
  full_name: Matoušek, Jiří
  last_name: Matoušek
- first_name: Eric
  full_name: Sedgwick, Eric
  last_name: Sedgwick
- first_name: Martin
  full_name: Tancer, Martin
  id: 38AC689C-F248-11E8-B48F-1D18A9856A87
  last_name: Tancer
  orcid: 0000-0002-1191-6714
- first_name: Uli
  full_name: Wagner, Uli
  id: 36690CA2-F248-11E8-B48F-1D18A9856A87
  last_name: Wagner
  orcid: 0000-0002-1494-0568
citation:
  ama: Matoušek J, Sedgwick E, Tancer M, Wagner U. Embeddability in the 3-Sphere is
    decidable. <i>Journal of the ACM</i>. 2018;65(1). doi:<a href="https://doi.org/10.1145/3078632">10.1145/3078632</a>
  apa: Matoušek, J., Sedgwick, E., Tancer, M., &#38; Wagner, U. (2018). Embeddability
    in the 3-Sphere is decidable. <i>Journal of the ACM</i>. ACM. <a href="https://doi.org/10.1145/3078632">https://doi.org/10.1145/3078632</a>
  chicago: Matoušek, Jiří, Eric Sedgwick, Martin Tancer, and Uli Wagner. “Embeddability
    in the 3-Sphere Is Decidable.” <i>Journal of the ACM</i>. ACM, 2018. <a href="https://doi.org/10.1145/3078632">https://doi.org/10.1145/3078632</a>.
  ieee: J. Matoušek, E. Sedgwick, M. Tancer, and U. Wagner, “Embeddability in the
    3-Sphere is decidable,” <i>Journal of the ACM</i>, vol. 65, no. 1. ACM, 2018.
  ista: Matoušek J, Sedgwick E, Tancer M, Wagner U. 2018. Embeddability in the 3-Sphere
    is decidable. Journal of the ACM. 65(1), 5.
  mla: Matoušek, Jiří, et al. “Embeddability in the 3-Sphere Is Decidable.” <i>Journal
    of the ACM</i>, vol. 65, no. 1, 5, ACM, 2018, doi:<a href="https://doi.org/10.1145/3078632">10.1145/3078632</a>.
  short: J. Matoušek, E. Sedgwick, M. Tancer, U. Wagner, Journal of the ACM 65 (2018).
date_created: 2018-12-11T11:46:24Z
date_published: 2018-01-01T00:00:00Z
date_updated: 2023-09-11T13:38:49Z
day: '01'
department:
- _id: UlWa
doi: 10.1145/3078632
ec_funded: 1
external_id:
  arxiv:
  - '1402.0815'
  isi:
  - '000425685900006'
intvolume: '        65'
isi: 1
issue: '1'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://arxiv.org/abs/1402.0815
month: '01'
oa: 1
oa_version: Preprint
project:
- _id: 25681D80-B435-11E9-9278-68D0E5697425
  call_identifier: FP7
  grant_number: '291734'
  name: International IST Postdoc Fellowship Programme
publication: Journal of the ACM
publication_status: published
publisher: ACM
publist_id: '7398'
quality_controlled: '1'
related_material:
  record:
  - id: '2157'
    relation: earlier_version
    status: public
scopus_import: '1'
status: public
title: Embeddability in the 3-Sphere is decidable
type: journal_article
user_id: c635000d-4b10-11ee-a964-aac5a93f6ac1
volume: 65
year: '2018'
...
---
_id: '426'
abstract:
- lang: eng
  text: Sperm cells are the most morphologically diverse cells across animal taxa.
    Within species, sperm and ejaculate traits have been suggested to vary with the
    male's competitive environment, e.g., level of sperm competition, female mating
    status and quality, and also with male age, body mass, physiological condition,
    and resource availability. Most previous studies have based their conclusions
    on the analysis of only one or a few ejaculates per male without investigating
    differences among the ejaculates of the same individual. This masks potential
    ejaculate-specific traits. Here, we provide data on the length, quantity, and
    viability of sperm ejaculated by wingless males of the ant Cardiocondyla obscurior.
    Males of this ant species are relatively long-lived and can mate with large numbers
    of female sexuals throughout their lives. We analyzed all ejaculates across the
    individuals' lifespan and manipulated the availability of mating partners. Our
    study shows that both the number and size of sperm cells transferred during copulations
    differ among individuals and also among ejaculates of the same male. Sperm quality
    does not decrease with male age, but the variation in sperm number between ejaculates
    indicates that males need considerable time to replenish their sperm supplies.
    Producing many ejaculates in a short time appears to be traded-off against male
    longevity rather than sperm quality.
acknowledgement: "Research with C. obscurior from Brazil was permitted by Instituto
  Brasileiro do Meio Ambiente e dos Recursos Naturais Renováveis, IBAMA (permit no.
  20324-1). We thank the German Science Foundation ( DFG ) for funding ( Schr1135/2-1
  ), T. Suckert for help with sperm length measurements and A.K. Huylmans for advice
  concerning graphs. One referee made helpful comments on the manuscript.\r\n"
article_processing_charge: No
author:
- first_name: Sina
  full_name: Metzler, Sina
  id: 48204546-F248-11E8-B48F-1D18A9856A87
  last_name: Metzler
  orcid: 0000-0002-9547-2494
- first_name: Alexandra
  full_name: Schrempf, Alexandra
  last_name: Schrempf
- first_name: Jürgen
  full_name: Heinze, Jürgen
  last_name: Heinze
citation:
  ama: Metzler S, Schrempf A, Heinze J. Individual- and ejaculate-specific sperm traits
    in ant males. <i>Journal of Insect Physiology</i>. 2018;107:284-290. doi:<a href="https://doi.org/10.1016/j.jinsphys.2017.12.003">10.1016/j.jinsphys.2017.12.003</a>
  apa: Metzler, S., Schrempf, A., &#38; Heinze, J. (2018). Individual- and ejaculate-specific
    sperm traits in ant males. <i>Journal of Insect Physiology</i>. Elsevier. <a href="https://doi.org/10.1016/j.jinsphys.2017.12.003">https://doi.org/10.1016/j.jinsphys.2017.12.003</a>
  chicago: Metzler, Sina, Alexandra Schrempf, and Jürgen Heinze. “Individual- and
    Ejaculate-Specific Sperm Traits in Ant Males.” <i>Journal of Insect Physiology</i>.
    Elsevier, 2018. <a href="https://doi.org/10.1016/j.jinsphys.2017.12.003">https://doi.org/10.1016/j.jinsphys.2017.12.003</a>.
  ieee: S. Metzler, A. Schrempf, and J. Heinze, “Individual- and ejaculate-specific
    sperm traits in ant males,” <i>Journal of Insect Physiology</i>, vol. 107. Elsevier,
    pp. 284–290, 2018.
  ista: Metzler S, Schrempf A, Heinze J. 2018. Individual- and ejaculate-specific
    sperm traits in ant males. Journal of Insect Physiology. 107, 284–290.
  mla: Metzler, Sina, et al. “Individual- and Ejaculate-Specific Sperm Traits in Ant
    Males.” <i>Journal of Insect Physiology</i>, vol. 107, Elsevier, 2018, pp. 284–90,
    doi:<a href="https://doi.org/10.1016/j.jinsphys.2017.12.003">10.1016/j.jinsphys.2017.12.003</a>.
  short: S. Metzler, A. Schrempf, J. Heinze, Journal of Insect Physiology 107 (2018)
    284–290.
date_created: 2018-12-11T11:46:25Z
date_published: 2018-05-01T00:00:00Z
date_updated: 2023-09-12T07:43:26Z
day: '01'
department:
- _id: SyCr
doi: 10.1016/j.jinsphys.2017.12.003
external_id:
  isi:
  - '000434751100034'
intvolume: '       107'
isi: 1
language:
- iso: eng
month: '05'
oa_version: None
page: 284-290
publication: Journal of Insect Physiology
publication_status: published
publisher: Elsevier
publist_id: '7397'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Individual- and ejaculate-specific sperm traits in ant males
type: journal_article
user_id: c635000d-4b10-11ee-a964-aac5a93f6ac1
volume: 107
year: '2018'
...
---
_id: '427'
abstract:
- lang: eng
  text: We investigate the quantum interference induced shifts between energetically
    close states in highly charged ions, with the energy structure being observed
    by laser spectroscopy. In this work, we focus on hyperfine states of lithiumlike
    heavy-Z isotopes and quantify how much quantum interference changes the observed
    transition frequencies. The process of photon excitation and subsequent photon
    decay for the transition 2s→2p→2s is implemented with fully relativistic and full-multipole
    frameworks, which are relevant for such relativistic atomic systems. We consider
    the isotopes Pb79+207 and Bi80+209 due to experimental interest, as well as other
    examples of isotopes with lower Z, namely Pr56+141 and Ho64+165. We conclude that
    quantum interference can induce shifts up to 11% of the linewidth in the measurable
    resonances of the considered isotopes, if interference between resonances is neglected.
    The inclusion of relativity decreases the cross section by 35%, mainly due to
    the complete retardation form of the electric dipole multipole. However, the contribution
    of the next higher multipoles (e.g., magnetic quadrupole) to the cross section
    is negligible. This makes the contribution of relativity and higher-order multipoles
    to the quantum interference induced shifts a minor effect, even for heavy-Z elements.
acknowledgement: "This work was funded by the Portuguese Fundação para a Ciência e
  a Tecnologia (FCT/MCTES/PIDDAC) under Grant No. UID/FIS/04559/2013 (LIBPhys). P.A.
  acknowledges the support of the FCT, under Contract No. SFRH/BPD/92329/2013. L.S.
  acknowledges financial support from the People Programme (Marie Curie Actions) of
  the European Union's Seventh Framework Programme (FP7/2007-2013) under REA Grant
  Agreement No. (291734). Laboratoire Kastler Brossel (LKB) is “Unité Mixte de Recherche
  de Sorbonne Université, de ENS-PSL Research University, du Collège de France et
  du CNRS No. 8552.” APPENDIX:\r\n"
article_number: '022510'
article_processing_charge: No
article_type: original
arxiv: 1
author:
- first_name: Pedro
  full_name: Amaro, Pedro
  last_name: Amaro
- first_name: Ulisses
  full_name: Loureiro, Ulisses
  last_name: Loureiro
- first_name: Laleh
  full_name: Safari, Laleh
  id: 3C325E5E-F248-11E8-B48F-1D18A9856A87
  last_name: Safari
- first_name: Filippo
  full_name: Fratini, Filippo
  last_name: Fratini
- first_name: Paul
  full_name: Indelicato, Paul
  last_name: Indelicato
- first_name: Thomas
  full_name: Stöhlker, Thomas
  last_name: Stöhlker
- first_name: José
  full_name: Santos, José
  last_name: Santos
citation:
  ama: Amaro P, Loureiro U, Safari L, et al. Quantum interference in laser spectroscopy
    of highly charged lithiumlike ions. <i> Physical Review A - Atomic, Molecular,
    and Optical Physics</i>. 2018;97(2). doi:<a href="https://doi.org/10.1103/PhysRevA.97.022510">10.1103/PhysRevA.97.022510</a>
  apa: Amaro, P., Loureiro, U., Safari, L., Fratini, F., Indelicato, P., Stöhlker,
    T., &#38; Santos, J. (2018). Quantum interference in laser spectroscopy of highly
    charged lithiumlike ions. <i> Physical Review A - Atomic, Molecular, and Optical
    Physics</i>. American Physical Society. <a href="https://doi.org/10.1103/PhysRevA.97.022510">https://doi.org/10.1103/PhysRevA.97.022510</a>
  chicago: Amaro, Pedro, Ulisses Loureiro, Laleh Safari, Filippo Fratini, Paul Indelicato,
    Thomas Stöhlker, and José Santos. “Quantum Interference in Laser Spectroscopy
    of Highly Charged Lithiumlike Ions.” <i> Physical Review A - Atomic, Molecular,
    and Optical Physics</i>. American Physical Society, 2018. <a href="https://doi.org/10.1103/PhysRevA.97.022510">https://doi.org/10.1103/PhysRevA.97.022510</a>.
  ieee: P. Amaro <i>et al.</i>, “Quantum interference in laser spectroscopy of highly
    charged lithiumlike ions,” <i> Physical Review A - Atomic, Molecular, and Optical
    Physics</i>, vol. 97, no. 2. American Physical Society, 2018.
  ista: Amaro P, Loureiro U, Safari L, Fratini F, Indelicato P, Stöhlker T, Santos
    J. 2018. Quantum interference in laser spectroscopy of highly charged lithiumlike
    ions.  Physical Review A - Atomic, Molecular, and Optical Physics. 97(2), 022510.
  mla: Amaro, Pedro, et al. “Quantum Interference in Laser Spectroscopy of Highly
    Charged Lithiumlike Ions.” <i> Physical Review A - Atomic, Molecular, and Optical
    Physics</i>, vol. 97, no. 2, 022510, American Physical Society, 2018, doi:<a href="https://doi.org/10.1103/PhysRevA.97.022510">10.1103/PhysRevA.97.022510</a>.
  short: P. Amaro, U. Loureiro, L. Safari, F. Fratini, P. Indelicato, T. Stöhlker,
    J. Santos,  Physical Review A - Atomic, Molecular, and Optical Physics 97 (2018).
date_created: 2018-12-11T11:46:25Z
date_published: 2018-02-21T00:00:00Z
date_updated: 2023-09-15T12:09:35Z
day: '21'
department:
- _id: MiLe
doi: 10.1103/PhysRevA.97.022510
ec_funded: 1
external_id:
  arxiv:
  - '1802.07920'
  isi:
  - '000425601000004'
intvolume: '        97'
isi: 1
issue: '2'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://arxiv.org/abs/1802.07920
month: '02'
oa: 1
oa_version: Preprint
project:
- _id: 25681D80-B435-11E9-9278-68D0E5697425
  call_identifier: FP7
  grant_number: '291734'
  name: International IST Postdoc Fellowship Programme
publication: ' Physical Review A - Atomic, Molecular, and Optical Physics'
publication_status: published
publisher: American Physical Society
publist_id: '7396'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Quantum interference in laser spectroscopy of highly charged lithiumlike ions
type: journal_article
user_id: c635000d-4b10-11ee-a964-aac5a93f6ac1
volume: 97
year: '2018'
...
---
_id: '428'
abstract:
- lang: eng
  text: The plant hormone gibberellic acid (GA) is a crucial regulator of growth and
    development. The main paradigm of GA signaling puts forward transcriptional regulation
    via the degradation of DELLA transcriptional repressors. GA has also been shown
    to regulate tropic responses by modulation of the plasma membrane incidence of
    PIN auxin transporters by an unclear mechanism. Here we uncovered the cellular
    and molecular mechanisms by which GA redirects protein trafficking and thus regulates
    cell surface functionality. Photoconvertible reporters revealed that GA balances
    the protein traffic between the vacuole degradation route and recycling back to
    the cell surface. Low GA levels promote vacuolar delivery and degradation of multiple
    cargos, including PIN proteins, whereas high GA levels promote their recycling
    to the plasma membrane. This GA effect requires components of the retromer complex,
    such as Sorting Nexin 1 (SNX1) and its interacting, microtubule (MT)-associated
    protein, the Cytoplasmic Linker-Associated Protein (CLASP1). Accordingly, GA regulates
    the subcellular distribution of SNX1 and CLASP1, and the intact MT cytoskeleton
    is essential for the GA effect on trafficking. This GA cellular action occurs
    through DELLA proteins that regulate the MT and retromer presumably via their
    interaction partners Prefoldins (PFDs). Our study identified a branching of the
    GA signaling pathway at the level of DELLA proteins, which, in parallel to regulating
    transcription, also target by a nontranscriptional mechanism the retromer complex
    acting at the intersection of the degradation and recycling trafficking routes.
    By this mechanism, GA can redirect receptors and transporters to the cell surface,
    thus coregulating multiple processes, including PIN-dependent auxin fluxes during
    tropic responses.
acknowledgement: "We gratefully acknowledge M. Blázquez (Instituto de Biología Molecular
  y Celular de Plantas), M. Fendrych, C. Cuesta Moliner (Institute of Science and
  Technology Austria), M. Vanstraelen, M. Nowack (Center for Plant Systems Biology,
  Ghent), C. Luschnig (Universitat fur Bodenkultur Wien, Vienna), S. Simon (Central
  European Institute of Technology, Brno), C. Sommerville (Carnegie Institution for
  Science), and Y. Gu (Penn State University) for making available the materials used
  in this study;\r\n...funding from the European Research Council (ERC) under the
  European Union’s Seventh Framework Programme (FP7/2007-2013)/ERC Grant Agreement
  282300.\r\nCC BY NC ND"
article_processing_charge: No
author:
- first_name: Yuliya
  full_name: Salanenka, Yuliya
  id: 46DAAE7E-F248-11E8-B48F-1D18A9856A87
  last_name: Salanenka
- first_name: Inge
  full_name: Verstraeten, Inge
  id: 362BF7FE-F248-11E8-B48F-1D18A9856A87
  last_name: Verstraeten
  orcid: 0000-0001-7241-2328
- first_name: Christian
  full_name: Löfke, Christian
  last_name: Löfke
- first_name: Kaori
  full_name: Tabata, Kaori
  id: 7DAAEDA4-02D0-11E9-B11A-A5A4D7DFFFD0
  last_name: Tabata
- first_name: Satoshi
  full_name: Naramoto, Satoshi
  last_name: Naramoto
- first_name: Matous
  full_name: Glanc, Matous
  id: 1AE1EA24-02D0-11E9-9BAA-DAF4881429F2
  last_name: Glanc
  orcid: 0000-0003-0619-7783
- first_name: Jirí
  full_name: Friml, Jirí
  id: 4159519E-F248-11E8-B48F-1D18A9856A87
  last_name: Friml
  orcid: 0000-0002-8302-7596
citation:
  ama: Salanenka Y, Verstraeten I, Löfke C, et al. Gibberellin DELLA signaling targets
    the retromer complex to redirect protein trafficking to the plasma membrane. <i>PNAS</i>.
    2018;115(14):3716-3721. doi:<a href="https://doi.org/10.1073/pnas.1721760115">10.1073/pnas.1721760115</a>
  apa: Salanenka, Y., Verstraeten, I., Löfke, C., Tabata, K., Naramoto, S., Glanc,
    M., &#38; Friml, J. (2018). Gibberellin DELLA signaling targets the retromer complex
    to redirect protein trafficking to the plasma membrane. <i>PNAS</i>. National
    Academy of Sciences. <a href="https://doi.org/10.1073/pnas.1721760115">https://doi.org/10.1073/pnas.1721760115</a>
  chicago: Salanenka, Yuliya, Inge Verstraeten, Christian Löfke, Kaori Tabata, Satoshi
    Naramoto, Matous Glanc, and Jiří Friml. “Gibberellin DELLA Signaling Targets the
    Retromer Complex to Redirect Protein Trafficking to the Plasma Membrane.” <i>PNAS</i>.
    National Academy of Sciences, 2018. <a href="https://doi.org/10.1073/pnas.1721760115">https://doi.org/10.1073/pnas.1721760115</a>.
  ieee: Y. Salanenka <i>et al.</i>, “Gibberellin DELLA signaling targets the retromer
    complex to redirect protein trafficking to the plasma membrane,” <i>PNAS</i>,
    vol. 115, no. 14. National Academy of Sciences, pp. 3716–3721, 2018.
  ista: Salanenka Y, Verstraeten I, Löfke C, Tabata K, Naramoto S, Glanc M, Friml
    J. 2018. Gibberellin DELLA signaling targets the retromer complex to redirect
    protein trafficking to the plasma membrane. PNAS. 115(14), 3716–3721.
  mla: Salanenka, Yuliya, et al. “Gibberellin DELLA Signaling Targets the Retromer
    Complex to Redirect Protein Trafficking to the Plasma Membrane.” <i>PNAS</i>,
    vol. 115, no. 14, National Academy of Sciences, 2018, pp. 3716–21, doi:<a href="https://doi.org/10.1073/pnas.1721760115">10.1073/pnas.1721760115</a>.
  short: Y. Salanenka, I. Verstraeten, C. Löfke, K. Tabata, S. Naramoto, M. Glanc,
    J. Friml, PNAS 115 (2018) 3716–3721.
date_created: 2018-12-11T11:46:25Z
date_published: 2018-04-03T00:00:00Z
date_updated: 2025-05-07T11:12:27Z
day: '03'
ddc:
- '580'
department:
- _id: JiFr
doi: 10.1073/pnas.1721760115
ec_funded: 1
external_id:
  isi:
  - '000429012500073'
file:
- access_level: open_access
  checksum: 1fcf7223fb8f99559cfa80bd6f24ce44
  content_type: application/pdf
  creator: dernst
  date_created: 2018-12-17T12:30:14Z
  date_updated: 2020-07-14T12:46:26Z
  file_id: '5700'
  file_name: 2018_PNAS_Salanenka.pdf
  file_size: 1924101
  relation: main_file
file_date_updated: 2020-07-14T12:46:26Z
has_accepted_license: '1'
intvolume: '       115'
isi: 1
issue: '14'
language:
- iso: eng
month: '04'
oa: 1
oa_version: Published Version
page: ' 3716 - 3721'
project:
- _id: 25716A02-B435-11E9-9278-68D0E5697425
  call_identifier: FP7
  grant_number: '282300'
  name: Polarity and subcellular dynamics in plants
publication: PNAS
publication_status: published
publisher: National Academy of Sciences
publist_id: '7395'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Gibberellin DELLA signaling targets the retromer complex to redirect protein
  trafficking to the plasma membrane
tmp:
  image: /images/cc_by_nc_nd.png
  legal_code_url: https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode
  name: Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
    (CC BY-NC-ND 4.0)
  short: CC BY-NC-ND (4.0)
type: journal_article
user_id: c635000d-4b10-11ee-a964-aac5a93f6ac1
volume: 115
year: '2018'
...
---
_id: '43'
abstract:
- lang: eng
  text: 'The initial amount of pathogens required to start an infection within a susceptible
    host is called the infective dose and is known to vary to a large extent between
    different pathogen species. We investigate the hypothesis that the differences
    in infective doses are explained by the mode of action in the underlying mechanism
    of pathogenesis: Pathogens with locally acting mechanisms tend to have smaller
    infective doses than pathogens with distantly acting mechanisms. While empirical
    evidence tends to support the hypothesis, a formal theoretical explanation has
    been lacking. We give simple analytical models to gain insight into this phenomenon
    and also investigate a stochastic, spatially explicit, mechanistic within-host
    model for toxin-dependent bacterial infections. The model shows that pathogens
    secreting locally acting toxins have smaller infective doses than pathogens secreting
    diffusive toxins, as hypothesized. While local pathogenetic mechanisms require
    smaller infective doses, pathogens with distantly acting toxins tend to spread
    faster and may cause more damage to the host. The proposed model can serve as
    a basis for the spatially explicit analysis of various virulence factors also
    in the context of other problems in infection dynamics.'
acknowledgement: J.R. and J.V.A. were also supported by the Academy of Finland Grants
  1273253 and 267541.
article_processing_charge: No
author:
- first_name: Joel
  full_name: Rybicki, Joel
  id: 334EFD2E-F248-11E8-B48F-1D18A9856A87
  last_name: Rybicki
  orcid: 0000-0002-6432-6646
- first_name: Eva
  full_name: Kisdi, Eva
  last_name: Kisdi
- first_name: Jani
  full_name: Anttila, Jani
  last_name: Anttila
citation:
  ama: Rybicki J, Kisdi E, Anttila J. Model of bacterial toxin-dependent pathogenesis
    explains infective dose. <i>PNAS</i>. 2018;115(42):10690-10695. doi:<a href="https://doi.org/10.1073/pnas.1721061115">10.1073/pnas.1721061115</a>
  apa: Rybicki, J., Kisdi, E., &#38; Anttila, J. (2018). Model of bacterial toxin-dependent
    pathogenesis explains infective dose. <i>PNAS</i>. National Academy of Sciences.
    <a href="https://doi.org/10.1073/pnas.1721061115">https://doi.org/10.1073/pnas.1721061115</a>
  chicago: Rybicki, Joel, Eva Kisdi, and Jani Anttila. “Model of Bacterial Toxin-Dependent
    Pathogenesis Explains Infective Dose.” <i>PNAS</i>. National Academy of Sciences,
    2018. <a href="https://doi.org/10.1073/pnas.1721061115">https://doi.org/10.1073/pnas.1721061115</a>.
  ieee: J. Rybicki, E. Kisdi, and J. Anttila, “Model of bacterial toxin-dependent
    pathogenesis explains infective dose,” <i>PNAS</i>, vol. 115, no. 42. National
    Academy of Sciences, pp. 10690–10695, 2018.
  ista: Rybicki J, Kisdi E, Anttila J. 2018. Model of bacterial toxin-dependent pathogenesis
    explains infective dose. PNAS. 115(42), 10690–10695.
  mla: Rybicki, Joel, et al. “Model of Bacterial Toxin-Dependent Pathogenesis Explains
    Infective Dose.” <i>PNAS</i>, vol. 115, no. 42, National Academy of Sciences,
    2018, pp. 10690–95, doi:<a href="https://doi.org/10.1073/pnas.1721061115">10.1073/pnas.1721061115</a>.
  short: J. Rybicki, E. Kisdi, J. Anttila, PNAS 115 (2018) 10690–10695.
date_created: 2018-12-11T11:44:19Z
date_published: 2018-10-02T00:00:00Z
date_updated: 2023-09-13T08:57:38Z
day: '02'
ddc:
- '570'
- '577'
department:
- _id: DaAl
doi: 10.1073/pnas.1721061115
ec_funded: 1
external_id:
  isi:
  - '000447491300057'
file:
- access_level: open_access
  checksum: df7ac544a587c06b75692653b9fabd18
  content_type: application/pdf
  creator: dernst
  date_created: 2019-04-09T08:02:50Z
  date_updated: 2020-07-14T12:46:26Z
  file_id: '6258'
  file_name: 2018_PNAS_Rybicki.pdf
  file_size: 4070777
  relation: main_file
file_date_updated: 2020-07-14T12:46:26Z
has_accepted_license: '1'
intvolume: '       115'
isi: 1
issue: '42'
language:
- iso: eng
month: '10'
oa: 1
oa_version: Submitted Version
page: 10690 - 10695
project:
- _id: 260C2330-B435-11E9-9278-68D0E5697425
  call_identifier: H2020
  grant_number: '754411'
  name: ISTplus - Postdoctoral Fellowships
publication: PNAS
publication_status: published
publisher: National Academy of Sciences
publist_id: '8011'
pubrep_id: '1063'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Model of bacterial toxin-dependent pathogenesis explains infective dose
type: journal_article
user_id: c635000d-4b10-11ee-a964-aac5a93f6ac1
volume: 115
year: '2018'
...
---
_id: '430'
abstract:
- lang: eng
  text: In this issue of GENETICS, a new method for detecting natural selection on
    polygenic traits is developed and applied to sev- eral human examples ( Racimo
    et al. 2018 ). By de fi nition, many loci contribute to variation in polygenic
    traits, and a challenge for evolutionary ge neticists has been that these traits
    can evolve by small, nearly undetectable shifts in allele frequencies across each
    of many, typically unknown, loci. Recently, a helpful remedy has arisen. Genome-wide
    associ- ation studies (GWAS) have been illuminating sets of loci that can be interrogated
    jointly for c hanges in allele frequencies. By aggregating small signal s of change
    across many such loci, directional natural selection is now in principle detect-
    able using genetic data, even for highly polygenic traits. This is an exciting
    arena of progress – with these methods, tests can be made for selection associated
    with traits, and we can now study selection in what may be its most prevalent
    mode. The continuing fast pace of GWAS publications suggest there will be many
    more polygenic tests of selection in the near future, as every new GWAS is an
    opportunity for an accom- panying test of polygenic selection. However, it is
    important to be aware of complications th at arise in interpretation, especially
    given that these studies may easily be misinter- preted both in and outside the
    evolutionary genetics commu- nity. Here, we provide context for understanding
    polygenic tests and urge caution regarding how these results are inter- preted
    and reported upon more broadly.
article_processing_charge: No
author:
- first_name: John
  full_name: Novembre, John
  last_name: Novembre
- first_name: Nicholas H
  full_name: Barton, Nicholas H
  id: 4880FE40-F248-11E8-B48F-1D18A9856A87
  last_name: Barton
  orcid: 0000-0002-8548-5240
citation:
  ama: Novembre J, Barton NH. Tread lightly interpreting polygenic tests of selection.
    <i>Genetics</i>. 2018;208(4):1351-1355. doi:<a href="https://doi.org/10.1534/genetics.118.300786">10.1534/genetics.118.300786</a>
  apa: Novembre, J., &#38; Barton, N. H. (2018). Tread lightly interpreting polygenic
    tests of selection. <i>Genetics</i>. Genetics Society of America. <a href="https://doi.org/10.1534/genetics.118.300786">https://doi.org/10.1534/genetics.118.300786</a>
  chicago: Novembre, John, and Nicholas H Barton. “Tread Lightly Interpreting Polygenic
    Tests of Selection.” <i>Genetics</i>. Genetics Society of America, 2018. <a href="https://doi.org/10.1534/genetics.118.300786">https://doi.org/10.1534/genetics.118.300786</a>.
  ieee: J. Novembre and N. H. Barton, “Tread lightly interpreting polygenic tests
    of selection,” <i>Genetics</i>, vol. 208, no. 4. Genetics Society of America,
    pp. 1351–1355, 2018.
  ista: Novembre J, Barton NH. 2018. Tread lightly interpreting polygenic tests of
    selection. Genetics. 208(4), 1351–1355.
  mla: Novembre, John, and Nicholas H. Barton. “Tread Lightly Interpreting Polygenic
    Tests of Selection.” <i>Genetics</i>, vol. 208, no. 4, Genetics Society of America,
    2018, pp. 1351–55, doi:<a href="https://doi.org/10.1534/genetics.118.300786">10.1534/genetics.118.300786</a>.
  short: J. Novembre, N.H. Barton, Genetics 208 (2018) 1351–1355.
date_created: 2018-12-11T11:46:26Z
date_published: 2018-04-01T00:00:00Z
date_updated: 2023-09-19T10:17:30Z
day: '01'
ddc:
- '576'
department:
- _id: NiBa
doi: 10.1534/genetics.118.300786
external_id:
  isi:
  - '000429094400005'
file:
- access_level: open_access
  checksum: 3d838dc285df394376555b794b6a5ad1
  content_type: application/pdf
  creator: system
  date_created: 2018-12-12T10:12:40Z
  date_updated: 2020-07-14T12:46:26Z
  file_id: '4958'
  file_name: IST-2018-1012-v1+1_2018_Barton_Tread.pdf
  file_size: 500129
  relation: main_file
file_date_updated: 2020-07-14T12:46:26Z
has_accepted_license: '1'
intvolume: '       208'
isi: 1
issue: '4'
language:
- iso: eng
month: '04'
oa: 1
oa_version: Published Version
page: 1351 - 1355
publication: Genetics
publication_status: published
publisher: Genetics Society of America
publist_id: '7393'
pubrep_id: '1012'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Tread lightly interpreting polygenic tests of selection
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: c635000d-4b10-11ee-a964-aac5a93f6ac1
volume: 208
year: '2018'
...
---
_id: '433'
abstract:
- lang: eng
  text: 'A thrackle is a graph drawn in the plane so that every pair of its edges
    meet exactly once: either at a common end vertex or in a proper crossing. We prove
    that any thrackle of n vertices has at most 1.3984n edges. Quasi-thrackles are
    defined similarly, except that every pair of edges that do not share a vertex
    are allowed to cross an odd number of times. It is also shown that the maximum
    number of edges of a quasi-thrackle on n vertices is 3/2(n-1), and that this bound
    is best possible for infinitely many values of n.'
alternative_title:
- LNCS
arxiv: 1
author:
- first_name: Radoslav
  full_name: Fulek, Radoslav
  id: 39F3FFE4-F248-11E8-B48F-1D18A9856A87
  last_name: Fulek
  orcid: 0000-0001-8485-1774
- first_name: János
  full_name: Pach, János
  last_name: Pach
citation:
  ama: 'Fulek R, Pach J. Thrackles: An improved upper bound. In: Vol 10692. Springer;
    2018:160-166. doi:<a href="https://doi.org/10.1007/978-3-319-73915-1_14">10.1007/978-3-319-73915-1_14</a>'
  apa: 'Fulek, R., &#38; Pach, J. (2018). Thrackles: An improved upper bound (Vol.
    10692, pp. 160–166). Presented at the GD 2017: Graph Drawing and Network Visualization,
    Boston, MA, United States: Springer. <a href="https://doi.org/10.1007/978-3-319-73915-1_14">https://doi.org/10.1007/978-3-319-73915-1_14</a>'
  chicago: 'Fulek, Radoslav, and János Pach. “Thrackles: An Improved Upper Bound,”
    10692:160–66. Springer, 2018. <a href="https://doi.org/10.1007/978-3-319-73915-1_14">https://doi.org/10.1007/978-3-319-73915-1_14</a>.'
  ieee: 'R. Fulek and J. Pach, “Thrackles: An improved upper bound,” presented at
    the GD 2017: Graph Drawing and Network Visualization, Boston, MA, United States,
    2018, vol. 10692, pp. 160–166.'
  ista: 'Fulek R, Pach J. 2018. Thrackles: An improved upper bound. GD 2017: Graph
    Drawing and Network Visualization, LNCS, vol. 10692, 160–166.'
  mla: 'Fulek, Radoslav, and János Pach. <i>Thrackles: An Improved Upper Bound</i>.
    Vol. 10692, Springer, 2018, pp. 160–66, doi:<a href="https://doi.org/10.1007/978-3-319-73915-1_14">10.1007/978-3-319-73915-1_14</a>.'
  short: R. Fulek, J. Pach, in:, Springer, 2018, pp. 160–166.
conference:
  end_date: 2017-09-27
  location: Boston, MA, United States
  name: 'GD 2017: Graph Drawing and Network Visualization'
  start_date: 201-09-25
date_created: 2018-12-11T11:46:27Z
date_published: 2018-01-21T00:00:00Z
date_updated: 2023-08-24T14:39:32Z
day: '21'
department:
- _id: UlWa
doi: 10.1007/978-3-319-73915-1_14
external_id:
  arxiv:
  - '1708.08037'
intvolume: '     10692'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://arxiv.org/abs/1708.08037
month: '01'
oa: 1
oa_version: Submitted Version
page: 160 - 166
publication_status: published
publisher: Springer
publist_id: '7390'
quality_controlled: '1'
related_material:
  record:
  - id: '5857'
    relation: later_version
    status: public
scopus_import: 1
status: public
title: 'Thrackles: An improved upper bound'
type: conference
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 10692
year: '2018'
...
---
_id: '434'
abstract:
- lang: eng
  text: In this paper, we present a formal model-driven design approach to establish
    a safety-assured implementation of multifunction vehicle bus controller (MVBC),
    which controls the data transmission among the devices of the vehicle. First,
    the generic models and safety requirements described in International Electrotechnical
    Commission Standard 61375 are formalized as time automata and timed computation
    tree logic formulas, respectively. With model checking tool Uppaal, we verify
    whether or not the constructed timed automata satisfy the formulas and several
    logic inconsistencies in the original standard are detected and corrected. Then,
    we apply the code generation tool Times to generate C code from the verified model,
    which is later synthesized into a real MVBC chip, with some handwriting glue code.
    Furthermore, the runtime verification tool RMOR is applied on the integrated code,
    to verify some safety requirements that cannot be formalized on the timed automata.
    For evaluation, we compare the proposed approach with existing MVBC design methods,
    such as BeagleBone, Galsblock, and Simulink. Experiments show that more ambiguousness
    or bugs in the standard are detected during Uppaal verification, and the generated
    code of Times outperforms the C code generated by others in terms of the synthesized
    binary code size. The errors in the standard have been confirmed and the resulting
    MVBC has been deployed in the real train communication network.
article_processing_charge: No
author:
- first_name: Yu
  full_name: Jiang, Yu
  last_name: Jiang
- first_name: Han
  full_name: Liu, Han
  last_name: Liu
- first_name: Huobing
  full_name: Song, Huobing
  last_name: Song
- first_name: Hui
  full_name: Kong, Hui
  id: 3BDE25AA-F248-11E8-B48F-1D18A9856A87
  last_name: Kong
  orcid: 0000-0002-3066-6941
- first_name: Rui
  full_name: Wang, Rui
  last_name: Wang
- first_name: Yong
  full_name: Guan, Yong
  last_name: Guan
- first_name: Lui
  full_name: Sha, Lui
  last_name: Sha
citation:
  ama: Jiang Y, Liu H, Song H, et al. Safety-assured model-driven design of the multifunction
    vehicle bus controller. <i>IEEE Transactions on Intelligent Transportation Systems</i>.
    2018;19(10):3320-3333. doi:<a href="https://doi.org/10.1109/TITS.2017.2778077">10.1109/TITS.2017.2778077</a>
  apa: Jiang, Y., Liu, H., Song, H., Kong, H., Wang, R., Guan, Y., &#38; Sha, L. (2018).
    Safety-assured model-driven design of the multifunction vehicle bus controller.
    <i>IEEE Transactions on Intelligent Transportation Systems</i>. IEEE. <a href="https://doi.org/10.1109/TITS.2017.2778077">https://doi.org/10.1109/TITS.2017.2778077</a>
  chicago: Jiang, Yu, Han Liu, Huobing Song, Hui Kong, Rui Wang, Yong Guan, and Lui
    Sha. “Safety-Assured Model-Driven Design of the Multifunction Vehicle Bus Controller.”
    <i>IEEE Transactions on Intelligent Transportation Systems</i>. IEEE, 2018. <a
    href="https://doi.org/10.1109/TITS.2017.2778077">https://doi.org/10.1109/TITS.2017.2778077</a>.
  ieee: Y. Jiang <i>et al.</i>, “Safety-assured model-driven design of the multifunction
    vehicle bus controller,” <i>IEEE Transactions on Intelligent Transportation Systems</i>,
    vol. 19, no. 10. IEEE, pp. 3320–3333, 2018.
  ista: Jiang Y, Liu H, Song H, Kong H, Wang R, Guan Y, Sha L. 2018. Safety-assured
    model-driven design of the multifunction vehicle bus controller. IEEE Transactions
    on Intelligent Transportation Systems. 19(10), 3320–3333.
  mla: Jiang, Yu, et al. “Safety-Assured Model-Driven Design of the Multifunction
    Vehicle Bus Controller.” <i>IEEE Transactions on Intelligent Transportation Systems</i>,
    vol. 19, no. 10, IEEE, 2018, pp. 3320–33, doi:<a href="https://doi.org/10.1109/TITS.2017.2778077">10.1109/TITS.2017.2778077</a>.
  short: Y. Jiang, H. Liu, H. Song, H. Kong, R. Wang, Y. Guan, L. Sha, IEEE Transactions
    on Intelligent Transportation Systems 19 (2018) 3320–3333.
date_created: 2018-12-11T11:46:27Z
date_published: 2018-01-01T00:00:00Z
date_updated: 2023-09-18T08:12:49Z
day: '01'
department:
- _id: ToHe
doi: 10.1109/TITS.2017.2778077
external_id:
  isi:
  - '000446651100020'
intvolume: '        19'
isi: 1
issue: '10'
language:
- iso: eng
month: '01'
oa_version: None
page: 3320 - 3333
publication: IEEE Transactions on Intelligent Transportation Systems
publication_status: published
publisher: IEEE
publist_id: '7389'
quality_controlled: '1'
related_material:
  record:
  - id: '1205'
    relation: earlier_version
    status: public
scopus_import: '1'
status: public
title: Safety-assured model-driven design of the multifunction vehicle bus controller
type: journal_article
user_id: c635000d-4b10-11ee-a964-aac5a93f6ac1
volume: 19
year: '2018'
...
---
_id: '435'
abstract:
- lang: eng
  text: It is shown that two fundamentally different phenomena, the bound states in
    continuum and the spectral singularity (or time-reversed spectral singularity),
    can occur simultaneously. This can be achieved in a rectangular core dielectric
    waveguide with an embedded active (or absorbing) layer. In such a system a two-dimensional
    bound state in a continuum is created in the plane of a waveguide cross section,
    and it is emitted or absorbed along the waveguide core. The idea can be used for
    experimental implementation of a laser or a coherent-perfect-absorber for a photonic
    bound state that resides in a continuous spectrum.
acknowledgement: 'Seventh Framework Programme (FP7) People: Marie-Curie Actions (PEOPLE)
  (291734). B. M. acknowledges the financial support by the People Programme (Marie
  Curie Actions) of the European Union’s Seventh Framework Programme (FP7/ 2007-2013)
  under REA.'
article_processing_charge: No
arxiv: 1
author:
- first_name: Bikashkali
  full_name: Midya, Bikashkali
  id: 456187FC-F248-11E8-B48F-1D18A9856A87
  last_name: Midya
- first_name: Vladimir
  full_name: Konotop, Vladimir
  last_name: Konotop
citation:
  ama: Midya B, Konotop V. Coherent-perfect-absorber and laser for bound states in
    a continuum. <i>Optics Letters</i>. 2018;43(3):607-610. doi:<a href="https://doi.org/10.1364/OL.43.000607">10.1364/OL.43.000607</a>
  apa: Midya, B., &#38; Konotop, V. (2018). Coherent-perfect-absorber and laser for
    bound states in a continuum. <i>Optics Letters</i>. Optica  Publishing Group.
    <a href="https://doi.org/10.1364/OL.43.000607">https://doi.org/10.1364/OL.43.000607</a>
  chicago: Midya, Bikashkali, and Vladimir Konotop. “Coherent-Perfect-Absorber and
    Laser for Bound States in a Continuum.” <i>Optics Letters</i>. Optica  Publishing
    Group, 2018. <a href="https://doi.org/10.1364/OL.43.000607">https://doi.org/10.1364/OL.43.000607</a>.
  ieee: B. Midya and V. Konotop, “Coherent-perfect-absorber and laser for bound states
    in a continuum,” <i>Optics Letters</i>, vol. 43, no. 3. Optica  Publishing Group,
    pp. 607–610, 2018.
  ista: Midya B, Konotop V. 2018. Coherent-perfect-absorber and laser for bound states
    in a continuum. Optics Letters. 43(3), 607–610.
  mla: Midya, Bikashkali, and Vladimir Konotop. “Coherent-Perfect-Absorber and Laser
    for Bound States in a Continuum.” <i>Optics Letters</i>, vol. 43, no. 3, Optica 
    Publishing Group, 2018, pp. 607–10, doi:<a href="https://doi.org/10.1364/OL.43.000607">10.1364/OL.43.000607</a>.
  short: B. Midya, V. Konotop, Optics Letters 43 (2018) 607–610.
date_created: 2018-12-11T11:46:27Z
date_published: 2018-02-01T00:00:00Z
date_updated: 2023-10-17T12:15:06Z
day: '01'
department:
- _id: MiLe
doi: 10.1364/OL.43.000607
ec_funded: 1
external_id:
  arxiv:
  - '1711.01986'
  isi:
  - '000423776600066'
intvolume: '        43'
isi: 1
issue: '3'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://arxiv.org/abs/1711.01986
month: '02'
oa: 1
oa_version: Preprint
page: 607 - 610
project:
- _id: 25681D80-B435-11E9-9278-68D0E5697425
  call_identifier: FP7
  grant_number: '291734'
  name: International IST Postdoc Fellowship Programme
publication: Optics Letters
publication_status: published
publisher: Optica  Publishing Group
publist_id: '7388'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Coherent-perfect-absorber and laser for bound states in a continuum
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 43
year: '2018'
...
---
_id: '436'
abstract:
- lang: eng
  text: There has been significant interest recently in using complex quantum systems
    to create effective nonreciprocal dynamics. Proposals have been put forward for
    the realization of artificial magnetic fields for photons and phonons; experimental
    progress is fast making these proposals a reality. Much work has concentrated
    on the use of such systems for controlling the flow of signals, e.g., to create
    isolators or directional amplifiers for optical signals. In this Letter, we build
    on this work but move in a different direction. We develop the theory of and discuss
    a potential realization for the controllable flow of thermal noise in quantum
    systems. We demonstrate theoretically that the unidirectional flow of thermal
    noise is possible within quantum cascaded systems. Viewing an optomechanical platform
    as a cascaded system we show here that one can ultimately control the direction
    of the flow of thermal noise. By appropriately engineering the mechanical resonator,
    which acts as an artificial reservoir, the flow of thermal noise can be constrained
    to a desired direction, yielding a thermal rectifier. The proposed quantum thermal
    noise rectifier could potentially be used to develop devices such as a thermal
    modulator, a thermal router, and a thermal amplifier for nanoelectronic devices
    and superconducting circuits.
article_number: '060601 '
article_processing_charge: No
arxiv: 1
author:
- first_name: Shabir
  full_name: Barzanjeh, Shabir
  id: 2D25E1F6-F248-11E8-B48F-1D18A9856A87
  last_name: Barzanjeh
  orcid: 0000-0003-0415-1423
- first_name: Matteo
  full_name: Aquilina, Matteo
  last_name: Aquilina
- first_name: André
  full_name: Xuereb, André
  last_name: Xuereb
citation:
  ama: Barzanjeh S, Aquilina M, Xuereb A. Manipulating the flow of thermal noise in
    quantum devices. <i>Physical Review Letters</i>. 2018;120(6). doi:<a href="https://doi.org/10.1103/PhysRevLett.120.060601">10.1103/PhysRevLett.120.060601</a>
  apa: Barzanjeh, S., Aquilina, M., &#38; Xuereb, A. (2018). Manipulating the flow
    of thermal noise in quantum devices. <i>Physical Review Letters</i>. American
    Physical Society. <a href="https://doi.org/10.1103/PhysRevLett.120.060601">https://doi.org/10.1103/PhysRevLett.120.060601</a>
  chicago: Barzanjeh, Shabir, Matteo Aquilina, and André Xuereb. “Manipulating the
    Flow of Thermal Noise in Quantum Devices.” <i>Physical Review Letters</i>. American
    Physical Society, 2018. <a href="https://doi.org/10.1103/PhysRevLett.120.060601">https://doi.org/10.1103/PhysRevLett.120.060601</a>.
  ieee: S. Barzanjeh, M. Aquilina, and A. Xuereb, “Manipulating the flow of thermal
    noise in quantum devices,” <i>Physical Review Letters</i>, vol. 120, no. 6. American
    Physical Society, 2018.
  ista: Barzanjeh S, Aquilina M, Xuereb A. 2018. Manipulating the flow of thermal
    noise in quantum devices. Physical Review Letters. 120(6), 060601.
  mla: Barzanjeh, Shabir, et al. “Manipulating the Flow of Thermal Noise in Quantum
    Devices.” <i>Physical Review Letters</i>, vol. 120, no. 6, 060601, American Physical
    Society, 2018, doi:<a href="https://doi.org/10.1103/PhysRevLett.120.060601">10.1103/PhysRevLett.120.060601</a>.
  short: S. Barzanjeh, M. Aquilina, A. Xuereb, Physical Review Letters 120 (2018).
date_created: 2018-12-11T11:46:28Z
date_published: 2018-02-07T00:00:00Z
date_updated: 2023-09-13T08:52:27Z
day: '07'
department:
- _id: JoFi
doi: 10.1103/PhysRevLett.120.060601
ec_funded: 1
external_id:
  arxiv:
  - '1706.09051'
  isi:
  - '000424382100004'
intvolume: '       120'
isi: 1
issue: '6'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://arxiv.org/abs/1706.09051
month: '02'
oa: 1
oa_version: Preprint
project:
- _id: 257EB838-B435-11E9-9278-68D0E5697425
  call_identifier: H2020
  grant_number: '732894'
  name: Hybrid Optomechanical Technologies
- _id: 258047B6-B435-11E9-9278-68D0E5697425
  call_identifier: H2020
  grant_number: '707438'
  name: 'Microwave-to-Optical Quantum Link: Quantum Teleportation and Quantum Illumination
    with cavity Optomechanics SUPEREOM'
publication: Physical Review Letters
publication_status: published
publisher: American Physical Society
publist_id: '7387'
quality_controlled: '1'
related_material:
  link:
  - description: News on IST Homepage
    relation: press_release
    url: https://ist.ac.at/en/news/interference-as-a-new-method-for-cooling-quantum-devices/
scopus_import: '1'
status: public
title: Manipulating the flow of thermal noise in quantum devices
type: journal_article
user_id: c635000d-4b10-11ee-a964-aac5a93f6ac1
volume: 120
year: '2018'
...
---
_id: '437'
abstract:
- lang: eng
  text: Dendritic cells (DCs) are sentinels of the adaptive immune system that reside
    in peripheral organs of mammals. Upon pathogen encounter, they undergo maturation
    and up-regulate the chemokine receptor CCR7 that guides them along gradients of
    its chemokine ligands CCL19 and 21 to the next draining lymph node. There, DCs
    present peripherally acquired antigen to naïve T cells, thereby triggering adaptive
    immunity.
acknowledged_ssus:
- _id: SSU
acknowledgement: "This work was supported by grants of the European Research Council
  (ERC CoG 724373) and the Austrian Science Fund (FWF) to M.S. We thank the scientific
  support units at IST Austria for excellent technical support.\r\nWe thank the  scientific
  \ support units at IST Austria for excellent technical support.   "
article_processing_charge: Yes (via OA deal)
author:
- first_name: Alexander F
  full_name: Leithner, Alexander F
  id: 3B1B77E4-F248-11E8-B48F-1D18A9856A87
  last_name: Leithner
  orcid: 0000-0002-1073-744X
- first_name: Jörg
  full_name: Renkawitz, Jörg
  id: 3F0587C8-F248-11E8-B48F-1D18A9856A87
  last_name: Renkawitz
  orcid: 0000-0003-2856-3369
- first_name: Ingrid
  full_name: De Vries, Ingrid
  id: 4C7D837E-F248-11E8-B48F-1D18A9856A87
  last_name: De Vries
- first_name: Robert
  full_name: Hauschild, Robert
  id: 4E01D6B4-F248-11E8-B48F-1D18A9856A87
  last_name: Hauschild
  orcid: 0000-0001-9843-3522
- first_name: Hans
  full_name: Haecker, Hans
  last_name: Haecker
- first_name: Michael K
  full_name: Sixt, Michael K
  id: 41E9FBEA-F248-11E8-B48F-1D18A9856A87
  last_name: Sixt
  orcid: 0000-0002-6620-9179
citation:
  ama: Leithner AF, Renkawitz J, de Vries I, Hauschild R, Haecker H, Sixt MK. Fast
    and efficient genetic engineering of hematopoietic precursor cells for the study
    of dendritic cell migration. <i>European Journal of Immunology</i>. 2018;48(6):1074-1077.
    doi:<a href="https://doi.org/10.1002/eji.201747358">10.1002/eji.201747358</a>
  apa: Leithner, A. F., Renkawitz, J., de Vries, I., Hauschild, R., Haecker, H., &#38;
    Sixt, M. K. (2018). Fast and efficient genetic engineering of hematopoietic precursor
    cells for the study of dendritic cell migration. <i>European Journal of Immunology</i>.
    Wiley-Blackwell. <a href="https://doi.org/10.1002/eji.201747358">https://doi.org/10.1002/eji.201747358</a>
  chicago: Leithner, Alexander F, Jörg Renkawitz, Ingrid de Vries, Robert Hauschild,
    Hans Haecker, and Michael K Sixt. “Fast and Efficient Genetic Engineering of Hematopoietic
    Precursor Cells for the Study of Dendritic Cell Migration.” <i>European Journal
    of Immunology</i>. Wiley-Blackwell, 2018. <a href="https://doi.org/10.1002/eji.201747358">https://doi.org/10.1002/eji.201747358</a>.
  ieee: A. F. Leithner, J. Renkawitz, I. de Vries, R. Hauschild, H. Haecker, and M.
    K. Sixt, “Fast and efficient genetic engineering of hematopoietic precursor cells
    for the study of dendritic cell migration,” <i>European Journal of Immunology</i>,
    vol. 48, no. 6. Wiley-Blackwell, pp. 1074–1077, 2018.
  ista: Leithner AF, Renkawitz J, de Vries I, Hauschild R, Haecker H, Sixt MK. 2018.
    Fast and efficient genetic engineering of hematopoietic precursor cells for the
    study of dendritic cell migration. European Journal of Immunology. 48(6), 1074–1077.
  mla: Leithner, Alexander F., et al. “Fast and Efficient Genetic Engineering of Hematopoietic
    Precursor Cells for the Study of Dendritic Cell Migration.” <i>European Journal
    of Immunology</i>, vol. 48, no. 6, Wiley-Blackwell, 2018, pp. 1074–77, doi:<a
    href="https://doi.org/10.1002/eji.201747358">10.1002/eji.201747358</a>.
  short: A.F. Leithner, J. Renkawitz, I. de Vries, R. Hauschild, H. Haecker, M.K.
    Sixt, European Journal of Immunology 48 (2018) 1074–1077.
date_created: 2018-12-11T11:46:28Z
date_published: 2018-02-13T00:00:00Z
date_updated: 2023-09-11T14:01:18Z
day: '13'
ddc:
- '570'
department:
- _id: MiSi
- _id: Bio
doi: 10.1002/eji.201747358
ec_funded: 1
external_id:
  isi:
  - '000434963700016'
file:
- access_level: open_access
  checksum: 9d5b74cd016505aeb9a4c2d33bbedaeb
  content_type: application/pdf
  creator: system
  date_created: 2018-12-12T10:13:56Z
  date_updated: 2020-07-14T12:46:27Z
  file_id: '5044'
  file_name: IST-2018-1067-v1+2_Leithner_et_al-2018-European_Journal_of_Immunology.pdf
  file_size: 590106
  relation: main_file
file_date_updated: 2020-07-14T12:46:27Z
has_accepted_license: '1'
intvolume: '        48'
isi: 1
issue: '6'
language:
- iso: eng
month: '02'
oa: 1
oa_version: Published Version
page: 1074 - 1077
project:
- _id: 25FE9508-B435-11E9-9278-68D0E5697425
  call_identifier: H2020
  grant_number: '724373'
  name: Cellular navigation along spatial gradients
publication: European Journal of Immunology
publication_status: published
publisher: Wiley-Blackwell
publist_id: '7386'
pubrep_id: '1067'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Fast and efficient genetic engineering of hematopoietic precursor cells for
  the study of dendritic cell migration
tmp:
  image: /images/cc_by_nc.png
  legal_code_url: https://creativecommons.org/licenses/by-nc/4.0/legalcode
  name: Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0)
  short: CC BY-NC (4.0)
type: journal_article
user_id: c635000d-4b10-11ee-a964-aac5a93f6ac1
volume: 48
year: '2018'
...
---
_id: '438'
abstract:
- lang: eng
  text: The MazF toxin sequence-specifically cleaves single-stranded RNA upon various
    stressful conditions, and it is activated as a part of the mazEF toxin–antitoxin
    module in Escherichia coli. Although autoregulation of mazEF expression through
    the MazE antitoxin-dependent transcriptional repression has been biochemically
    characterized, less is known about post-transcriptional autoregulation, as well
    as how both of these autoregulatory features affect growth of single cells during
    conditions that promote MazF production. Here, we demonstrate post-transcriptional
    autoregulation of mazF expression dynamics by MazF cleaving its own transcript.
    Single-cell analyses of bacterial populations during ectopic MazF production indicated
    that two-level autoregulation of mazEF expression influences cell-to-cell growth
    rate heterogeneity. The increase in growth rate heterogeneity is governed by the
    MazE antitoxin, and tuned by the MazF-dependent mazF mRNA cleavage. Also, both
    autoregulatory features grant rapid exit from the stress caused by mazF overexpression.
    Time-lapse microscopy revealed that MazF-mediated cleavage of mazF mRNA leads
    to increased temporal variability in length of individual cells during ectopic
    mazF overexpression, as explained by a stochastic model indicating that mazEF
    mRNA cleavage underlies temporal fluctuations in MazF levels during stress.
article_processing_charge: Yes (in subscription journal)
author:
- first_name: Nela
  full_name: Nikolic, Nela
  id: 42D9CABC-F248-11E8-B48F-1D18A9856A87
  last_name: Nikolic
  orcid: 0000-0001-9068-6090
- first_name: Tobias
  full_name: Bergmiller, Tobias
  id: 2C471CFA-F248-11E8-B48F-1D18A9856A87
  last_name: Bergmiller
  orcid: 0000-0001-5396-4346
- first_name: Alexandra
  full_name: Vandervelde, Alexandra
  last_name: Vandervelde
- first_name: Tanino
  full_name: Albanese, Tanino
  last_name: Albanese
- first_name: Lendert
  full_name: Gelens, Lendert
  last_name: Gelens
- first_name: Isabella
  full_name: Moll, Isabella
  last_name: Moll
citation:
  ama: Nikolic N, Bergmiller T, Vandervelde A, Albanese T, Gelens L, Moll I. Autoregulation
    of mazEF expression underlies growth heterogeneity in bacterial populations. <i>Nucleic
    Acids Research</i>. 2018;46(6):2918-2931. doi:<a href="https://doi.org/10.1093/nar/gky079">10.1093/nar/gky079</a>
  apa: Nikolic, N., Bergmiller, T., Vandervelde, A., Albanese, T., Gelens, L., &#38;
    Moll, I. (2018). Autoregulation of mazEF expression underlies growth heterogeneity
    in bacterial populations. <i>Nucleic Acids Research</i>. Oxford University Press.
    <a href="https://doi.org/10.1093/nar/gky079">https://doi.org/10.1093/nar/gky079</a>
  chicago: Nikolic, Nela, Tobias Bergmiller, Alexandra Vandervelde, Tanino Albanese,
    Lendert Gelens, and Isabella Moll. “Autoregulation of MazEF Expression Underlies
    Growth Heterogeneity in Bacterial Populations.” <i>Nucleic Acids Research</i>.
    Oxford University Press, 2018. <a href="https://doi.org/10.1093/nar/gky079">https://doi.org/10.1093/nar/gky079</a>.
  ieee: N. Nikolic, T. Bergmiller, A. Vandervelde, T. Albanese, L. Gelens, and I.
    Moll, “Autoregulation of mazEF expression underlies growth heterogeneity in bacterial
    populations,” <i>Nucleic Acids Research</i>, vol. 46, no. 6. Oxford University
    Press, pp. 2918–2931, 2018.
  ista: Nikolic N, Bergmiller T, Vandervelde A, Albanese T, Gelens L, Moll I. 2018.
    Autoregulation of mazEF expression underlies growth heterogeneity in bacterial
    populations. Nucleic Acids Research. 46(6), 2918–2931.
  mla: Nikolic, Nela, et al. “Autoregulation of MazEF Expression Underlies Growth
    Heterogeneity in Bacterial Populations.” <i>Nucleic Acids Research</i>, vol. 46,
    no. 6, Oxford University Press, 2018, pp. 2918–31, doi:<a href="https://doi.org/10.1093/nar/gky079">10.1093/nar/gky079</a>.
  short: N. Nikolic, T. Bergmiller, A. Vandervelde, T. Albanese, L. Gelens, I. Moll,
    Nucleic Acids Research 46 (2018) 2918–2931.
date_created: 2018-12-11T11:46:29Z
date_published: 2018-04-06T00:00:00Z
date_updated: 2024-02-21T13:44:45Z
day: '06'
ddc:
- '576'
department:
- _id: CaGu
doi: 10.1093/nar/gky079
external_id:
  isi:
  - '000429009500021'
file:
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  checksum: 3ff4f545c27e11a4cd20ccb30778793e
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  creator: system
  date_created: 2018-12-12T10:15:30Z
  date_updated: 2020-07-14T12:46:27Z
  file_id: '5151'
  file_name: IST-2018-971-v1+1_2018_Nikoloc_Autoregulation_of.pdf
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file_date_updated: 2020-07-14T12:46:27Z
has_accepted_license: '1'
intvolume: '        46'
isi: 1
issue: '6'
language:
- iso: eng
month: '04'
oa: 1
oa_version: Published Version
page: 2918-2931
project:
- _id: 3AC91DDA-15DF-11EA-824D-93A3E7B544D1
  call_identifier: FWF
  name: FWF Open Access Fund
publication: Nucleic Acids Research
publication_status: published
publisher: Oxford University Press
pubrep_id: '971'
quality_controlled: '1'
related_material:
  record:
  - id: '5569'
    relation: popular_science
    status: public
scopus_import: '1'
status: public
title: Autoregulation of mazEF expression underlies growth heterogeneity in bacterial
  populations
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: c635000d-4b10-11ee-a964-aac5a93f6ac1
volume: 46
year: '2018'
...
