---
_id: '6060'
article_processing_charge: No
author:
- first_name: Beatriz
  full_name: Vicoso, Beatriz
  id: 49E1C5C6-F248-11E8-B48F-1D18A9856A87
  last_name: Vicoso
  orcid: 0000-0002-4579-8306
citation:
  ama: Vicoso B. Supplementary data for “Sex-biased gene expression and dosage compensation
    on the Artemia franciscana Z-chromosome” (Huylman, Toups et al., 2019). . 2019.
    doi:<a href="https://doi.org/10.15479/AT:ISTA:6060">10.15479/AT:ISTA:6060</a>
  apa: Vicoso, B. (2019). Supplementary data for “Sex-biased gene expression and dosage
    compensation on the Artemia franciscana Z-chromosome” (Huylman, Toups et al.,
    2019). . Institute of Science and Technology Austria. <a href="https://doi.org/10.15479/AT:ISTA:6060">https://doi.org/10.15479/AT:ISTA:6060</a>
  chicago: Vicoso, Beatriz. “Supplementary Data for ‘Sex-Biased Gene Expression and
    Dosage Compensation on the Artemia Franciscana Z-Chromosome’ (Huylman, Toups et
    Al., 2019). .” Institute of Science and Technology Austria, 2019. <a href="https://doi.org/10.15479/AT:ISTA:6060">https://doi.org/10.15479/AT:ISTA:6060</a>.
  ieee: B. Vicoso, “Supplementary data for ‘Sex-biased gene expression and dosage
    compensation on the Artemia franciscana Z-chromosome’ (Huylman, Toups et al.,
    2019). .” Institute of Science and Technology Austria, 2019.
  ista: Vicoso B. 2019. Supplementary data for ‘Sex-biased gene expression and dosage
    compensation on the Artemia franciscana Z-chromosome’ (Huylman, Toups et al.,
    2019). , Institute of Science and Technology Austria, <a href="https://doi.org/10.15479/AT:ISTA:6060">10.15479/AT:ISTA:6060</a>.
  mla: Vicoso, Beatriz. <i>Supplementary Data for “Sex-Biased Gene Expression and
    Dosage Compensation on the Artemia Franciscana Z-Chromosome” (Huylman, Toups et
    Al., 2019). </i>. Institute of Science and Technology Austria, 2019, doi:<a href="https://doi.org/10.15479/AT:ISTA:6060">10.15479/AT:ISTA:6060</a>.
  short: B. Vicoso, (2019).
date_created: 2019-02-28T10:55:15Z
date_published: 2019-02-28T00:00:00Z
date_updated: 2024-02-21T12:45:42Z
day: '28'
department:
- _id: BeVi
doi: 10.15479/AT:ISTA:6060
file:
- access_level: open_access
  checksum: a338a622d728af0e3199cb07e6dd64d3
  content_type: application/zip
  creator: bvicoso
  date_created: 2019-02-28T10:54:27Z
  date_updated: 2020-07-14T12:47:17Z
  file_id: '6061'
  file_name: SupData.zip
  file_size: 36646050
  relation: main_file
file_date_updated: 2020-07-14T12:47:17Z
has_accepted_license: '1'
month: '02'
oa: 1
oa_version: Published Version
publisher: Institute of Science and Technology Austria
related_material:
  record:
  - id: '6418'
    relation: research_paper
    status: public
status: public
title: 'Supplementary data for "Sex-biased gene expression and dosage compensation
  on the Artemia franciscana Z-chromosome" (Huylman, Toups et al., 2019). '
type: research_data
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '2019'
...
---
_id: '6062'
abstract:
- lang: eng
  text: Open the files in Jupyter Notebook (reccomended https://www.anaconda.com/distribution/#download-section
    with Python 3.7).
article_processing_charge: No
author:
- first_name: Michele
  full_name: Nardin, Michele
  id: 30BD0376-F248-11E8-B48F-1D18A9856A87
  last_name: Nardin
  orcid: 0000-0001-8849-6570
citation:
  ama: Nardin M. Supplementary Code and Data for the paper “The Entorhinal Cognitive
    Map is Attracted to Goals.” 2019. doi:<a href="https://doi.org/10.15479/AT:ISTA:6062">10.15479/AT:ISTA:6062</a>
  apa: Nardin, M. (2019). Supplementary Code and Data for the paper “The Entorhinal
    Cognitive Map is Attracted to Goals.” Institute of Science and Technology Austria.
    <a href="https://doi.org/10.15479/AT:ISTA:6062">https://doi.org/10.15479/AT:ISTA:6062</a>
  chicago: Nardin, Michele. “Supplementary Code and Data for the Paper ‘The Entorhinal
    Cognitive Map Is Attracted to Goals.’” Institute of Science and Technology Austria,
    2019. <a href="https://doi.org/10.15479/AT:ISTA:6062">https://doi.org/10.15479/AT:ISTA:6062</a>.
  ieee: M. Nardin, “Supplementary Code and Data for the paper ‘The Entorhinal Cognitive
    Map is Attracted to Goals.’” Institute of Science and Technology Austria, 2019.
  ista: Nardin M. 2019. Supplementary Code and Data for the paper ‘The Entorhinal
    Cognitive Map is Attracted to Goals’, Institute of Science and Technology Austria,
    <a href="https://doi.org/10.15479/AT:ISTA:6062">10.15479/AT:ISTA:6062</a>.
  mla: Nardin, Michele. <i>Supplementary Code and Data for the Paper “The Entorhinal
    Cognitive Map Is Attracted to Goals.”</i> Institute of Science and Technology
    Austria, 2019, doi:<a href="https://doi.org/10.15479/AT:ISTA:6062">10.15479/AT:ISTA:6062</a>.
  short: M. Nardin, (2019).
date_created: 2019-03-04T14:20:58Z
date_published: 2019-03-29T00:00:00Z
date_updated: 2024-02-21T12:46:04Z
day: '29'
department:
- _id: JoCs
doi: 10.15479/AT:ISTA:6062
file:
- access_level: open_access
  checksum: 48e7b9a02939b763417733239522a236
  content_type: application/zip
  creator: mnardin
  date_created: 2019-03-05T09:29:37Z
  date_updated: 2020-07-14T12:47:18Z
  file_id: '6068'
  file_name: Online_data.zip
  file_size: 37002186
  relation: main_file
  title: Data for the paper "The Entorhinal Cognitive Map is Attracted to Goals"
file_date_updated: 2020-07-14T12:47:18Z
has_accepted_license: '1'
license: https://creativecommons.org/licenses/by-sa/4.0/
month: '03'
oa: 1
oa_version: Published Version
publisher: Institute of Science and Technology Austria
related_material:
  record:
  - id: '6194'
    relation: research_paper
    status: public
status: public
title: Supplementary Code and Data for the paper "The Entorhinal Cognitive Map is
  Attracted to Goals"
tmp:
  image: /images/cc_by_sa.png
  legal_code_url: https://creativecommons.org/licenses/by-sa/4.0/legalcode
  name: Creative Commons Attribution-ShareAlike 4.0 International Public License (CC
    BY-SA 4.0)
  short: CC BY-SA (4.0)
type: research_data
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '2019'
...
---
_id: '6069'
abstract:
- lang: eng
  text: Electron transport in two-dimensional conducting materials such as graphene,
    with dominant electron–electron interaction, exhibits unusual vortex flow that
    leads to a nonlocal current-field relation (negative resistance), distinct from
    the classical Ohm’s law. The transport behavior of these materials is best described
    by low Reynolds number hydrodynamics, where the constitutive pressure–speed relation
    is Stoke’s law. Here we report evidence of such vortices observed in a viscous
    flow of Newtonian fluid in a microfluidic device consisting of a rectangular cavity—analogous
    to the electronic system. We extend our experimental observations to elliptic
    cavities of different eccentricities, and validate them by numerically solving
    bi-harmonic equation obtained for the viscous flow with no-slip boundary conditions.
    We verify the existence of a  predicted threshold at which vortices appear. Strikingly,
    we find that a two-dimensional theoretical model captures the essential features
    of three-dimensional Stokes flow in experiments.
article_number: '937'
article_processing_charge: No
author:
- first_name: Jonathan
  full_name: Mayzel, Jonathan
  last_name: Mayzel
- first_name: Victor
  full_name: Steinberg, Victor
  last_name: Steinberg
- first_name: Atul
  full_name: Varshney, Atul
  id: 2A2006B2-F248-11E8-B48F-1D18A9856A87
  last_name: Varshney
  orcid: 0000-0002-3072-5999
citation:
  ama: Mayzel J, Steinberg V, Varshney A. Stokes flow analogous to viscous electron
    current in graphene. <i>Nature Communications</i>. 2019;10. doi:<a href="https://doi.org/10.1038/s41467-019-08916-5">10.1038/s41467-019-08916-5</a>
  apa: Mayzel, J., Steinberg, V., &#38; Varshney, A. (2019). Stokes flow analogous
    to viscous electron current in graphene. <i>Nature Communications</i>. Springer
    Nature. <a href="https://doi.org/10.1038/s41467-019-08916-5">https://doi.org/10.1038/s41467-019-08916-5</a>
  chicago: Mayzel, Jonathan, Victor Steinberg, and Atul Varshney. “Stokes Flow Analogous
    to Viscous Electron Current in Graphene.” <i>Nature Communications</i>. Springer
    Nature, 2019. <a href="https://doi.org/10.1038/s41467-019-08916-5">https://doi.org/10.1038/s41467-019-08916-5</a>.
  ieee: J. Mayzel, V. Steinberg, and A. Varshney, “Stokes flow analogous to viscous
    electron current in graphene,” <i>Nature Communications</i>, vol. 10. Springer
    Nature, 2019.
  ista: Mayzel J, Steinberg V, Varshney A. 2019. Stokes flow analogous to viscous
    electron current in graphene. Nature Communications. 10, 937.
  mla: Mayzel, Jonathan, et al. “Stokes Flow Analogous to Viscous Electron Current
    in Graphene.” <i>Nature Communications</i>, vol. 10, 937, Springer Nature, 2019,
    doi:<a href="https://doi.org/10.1038/s41467-019-08916-5">10.1038/s41467-019-08916-5</a>.
  short: J. Mayzel, V. Steinberg, A. Varshney, Nature Communications 10 (2019).
date_created: 2019-03-05T13:18:30Z
date_published: 2019-02-26T00:00:00Z
date_updated: 2023-09-08T11:39:02Z
day: '26'
ddc:
- '530'
- '532'
department:
- _id: BjHo
doi: 10.1038/s41467-019-08916-5
ec_funded: 1
external_id:
  isi:
  - '000459704600001'
file:
- access_level: open_access
  checksum: 61192fc49e0d44907c2a4fe384e4b97f
  content_type: application/pdf
  creator: dernst
  date_created: 2019-03-05T13:33:04Z
  date_updated: 2020-07-14T12:47:18Z
  file_id: '6070'
  file_name: 2019_NatureComm_Mayzel.pdf
  file_size: 2646391
  relation: main_file
file_date_updated: 2020-07-14T12:47:18Z
has_accepted_license: '1'
intvolume: '        10'
isi: 1
language:
- iso: eng
month: '02'
oa: 1
oa_version: Published Version
project:
- _id: 260C2330-B435-11E9-9278-68D0E5697425
  call_identifier: H2020
  grant_number: '754411'
  name: ISTplus - Postdoctoral Fellowships
publication: Nature Communications
publication_identifier:
  issn:
  - 2041-1723
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
scopus_import: '1'
status: public
title: Stokes flow analogous to viscous electron current in graphene
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: c635000d-4b10-11ee-a964-aac5a93f6ac1
volume: 10
year: '2019'
...
---
_id: '6071'
abstract:
- lang: eng
  text: 'Transcription factors, by binding to specific sequences on the DNA, control
    the precise spatio-temporal expression of genes inside a cell. However, this specificity
    is limited, leading to frequent incorrect binding of transcription factors that
    might have deleterious consequences on the cell. By constructing a biophysical
    model of TF-DNA binding in the context of gene regulation, I will first explore
    how regulatory constraints can strongly shape the distribution of a population
    in sequence space. Then, by directly linking this to a picture of multiple types
    of transcription factors performing their functions simultaneously inside the
    cell, I will explore the extent of regulatory crosstalk -- incorrect binding interactions
    between transcription factors and binding sites that lead to erroneous regulatory
    states -- and understand the constraints this places on the design of regulatory
    systems. I will then develop a generic theoretical framework to investigate the
    coevolution of multiple transcription factors and multiple binding sites, in the
    context of a gene regulatory network that performs a certain function. As a particular
    tractable version of this problem, I will consider the evolution of two transcription
    factors when they transmit upstream signals to downstream target genes. Specifically,
    I will describe the evolutionary steady states and the evolutionary pathways involved,
    along with their timescales, of a system that initially undergoes a transcription
    factor duplication event. To connect this important theoretical model to the prominent
    biological event of transcription factor duplication giving rise to paralogous
    families, I will then describe a bioinformatics analysis of C2H2 Zn-finger transcription
    factors, a major family in humans, and focus on the patterns of evolution that
    paralogs have undergone in their various protein domains in the recent past. '
alternative_title:
- ISTA Thesis
article_processing_charge: No
author:
- first_name: Roshan
  full_name: Prizak, Roshan
  id: 4456104E-F248-11E8-B48F-1D18A9856A87
  last_name: Prizak
citation:
  ama: Prizak R. Coevolution of transcription factors and their binding sites in sequence
    space. 2019. doi:<a href="https://doi.org/10.15479/at:ista:th6071">10.15479/at:ista:th6071</a>
  apa: Prizak, R. (2019). <i>Coevolution of transcription factors and their binding
    sites in sequence space</i>. Institute of Science and Technology Austria. <a href="https://doi.org/10.15479/at:ista:th6071">https://doi.org/10.15479/at:ista:th6071</a>
  chicago: Prizak, Roshan. “Coevolution of Transcription Factors and Their Binding
    Sites in Sequence Space.” Institute of Science and Technology Austria, 2019. <a
    href="https://doi.org/10.15479/at:ista:th6071">https://doi.org/10.15479/at:ista:th6071</a>.
  ieee: R. Prizak, “Coevolution of transcription factors and their binding sites in
    sequence space,” Institute of Science and Technology Austria, 2019.
  ista: Prizak R. 2019. Coevolution of transcription factors and their binding sites
    in sequence space. Institute of Science and Technology Austria.
  mla: Prizak, Roshan. <i>Coevolution of Transcription Factors and Their Binding Sites
    in Sequence Space</i>. Institute of Science and Technology Austria, 2019, doi:<a
    href="https://doi.org/10.15479/at:ista:th6071">10.15479/at:ista:th6071</a>.
  short: R. Prizak, Coevolution of Transcription Factors and Their Binding Sites in
    Sequence Space, Institute of Science and Technology Austria, 2019.
date_created: 2019-03-06T16:16:10Z
date_published: 2019-03-11T00:00:00Z
date_updated: 2025-05-28T11:57:05Z
day: '11'
ddc:
- '576'
degree_awarded: PhD
department:
- _id: GaTk
- _id: NiBa
doi: 10.15479/at:ista:th6071
file:
- access_level: open_access
  checksum: e60a72de35d270b31f1a23d50f224ec0
  content_type: application/pdf
  creator: rprizak
  date_created: 2019-03-06T16:05:07Z
  date_updated: 2020-07-14T12:47:18Z
  file_id: '6072'
  file_name: Thesis_final_PDFA_RoshanPrizak.pdf
  file_size: 20995465
  relation: main_file
- access_level: closed
  checksum: 67c2630333d05ebafef5f018863a8465
  content_type: application/zip
  creator: rprizak
  date_created: 2019-03-06T16:09:39Z
  date_updated: 2020-07-14T12:47:18Z
  file_id: '6073'
  file_name: thesis_v2_merge.zip
  file_size: 85705272
  relation: source_file
  title: Latex files
file_date_updated: 2020-07-14T12:47:18Z
has_accepted_license: '1'
language:
- iso: eng
month: '03'
oa: 1
oa_version: Published Version
page: '189'
project:
- _id: 254E9036-B435-11E9-9278-68D0E5697425
  call_identifier: FWF
  grant_number: P28844-B27
  name: Biophysics of information processing in gene regulation
publication_identifier:
  issn:
  - 2663-337X
publication_status: published
publisher: Institute of Science and Technology Austria
related_material:
  record:
  - id: '1358'
    relation: part_of_dissertation
    status: public
  - id: '955'
    relation: part_of_dissertation
    status: public
status: public
supervisor:
- first_name: Gašper
  full_name: Tkačik, Gašper
  id: 3D494DCA-F248-11E8-B48F-1D18A9856A87
  last_name: Tkačik
  orcid: 0000-0002-6699-1455
title: Coevolution of transcription factors and their binding sites in sequence space
type: dissertation
user_id: c635000d-4b10-11ee-a964-aac5a93f6ac1
year: '2019'
...
---
_id: '6074'
abstract:
- lang: eng
  text: "This dataset contains the supplementary data for the research paper \"Haploinsufficiency
    of the intellectual disability gene SETD5 disturbs developmental gene expression
    and cognition\".\r\n\r\nThe contained files have the following content:\r\n'Supplementary
    Figures.pdf'\r\n\tAdditional figures (as referenced in the paper).\r\n'Supplementary
    Table 1. Statistics.xlsx'\r\n\tDetails on statistical tests performed in the paper.\r\n'Supplementary
    Table 2. Differentially expressed gene analysis.xlsx'\r\n\tResults for the differential
    gene expression analysis for embryonic (E9.5; analysis with edgeR) and in vitro
    (ESCs, EBs, NPCs; analysis with DESeq2) samples.\r\n'Supplementary Table 3. Gene
    Ontology (GO) term enrichment analysis.xlsx'\r\n\tResults for the GO term enrichment
    analysis for differentially expressed genes in embryonic (GO E9.5) and in vitro
    (GO ESC, GO EBs, GO NPCs) samples. Differentially expressed genes for in vitro
    samples were split into upregulated and downregulated genes (up/down) and the
    analysis was performed on each subset (e.g. GO ESC up / GO ESC down).\r\n'Supplementary
    Table 4. Differentially expressed gene analysis for CFC samples.xlsx'\r\n\tResults
    for the differential gene expression analysis for samples from adult mice before
    (HC - Homecage) and 1h and 3h after contextual fear conditioning (1h and 3h, respectively).
    Each sheet shows the results for a different comparison. Sheets 1-3 show results
    for comparisons between timepoints for wild type (WT) samples only and sheets
    4-6 for the same comparisons in mutant (Het) samples. Sheets 7-9 show results
    for comparisons between genotypes at each time point and sheet 10 contains the
    results for the analysis of differential expression trajectories between wild
    type and mutant.\r\n'Supplementary Table 5. Cluster identification.xlsx'\r\n\tResults
    for k-means clustering of genes by expression. Sheet 1 shows clustering of just
    the genes with significantly different expression trajectories between genotypes.
    Sheet 2 shows clustering of all genes that are significantly differentially expressed
    in any of the comparisons (includes also genes with same trajectories).\r\n'Supplementary
    Table 6. GO term cluster analysis.xlsx'\r\n\tResults for the GO term enrichment
    analysis and EWCE analysis for enrichment of cell type specific genes for each
    cluster identified by clustering genes with different expression trajectories
    (see Table S5, sheet 1).\r\n'Supplementary Table 7. Setd5 mass spectrometry results.xlsx'\r\n\tResults
    showing proteins interacting with Setd5 as identified by mass spectrometry. Sheet
    1 shows protein protein interaction data generated from these results (combined
    with data from the STRING database. Sheet 2 shows the results of the statistical
    analysis with limma.\r\n'Supplementary Table 8. PolII ChIP-seq analysis.xlsx'\r\n\tResults
    for the Chip-Seq analysis for binding of RNA polymerase II (PolII). Sheet 1 shows
    results for differential binding of PolII at the transcription start site (TSS)
    between genotypes and sheets 2+3 show the corresponding GO enrichment analysis
    for these differentially bound genes. Sheet 4 shows RNAseq counts for genes with
    increased binding of PolII at the TSS."
article_processing_charge: No
author:
- first_name: Christoph
  full_name: Dotter, Christoph
  id: 4C66542E-F248-11E8-B48F-1D18A9856A87
  last_name: Dotter
  orcid: 0000-0002-9033-9096
- first_name: Gaia
  full_name: Novarino, Gaia
  id: 3E57A680-F248-11E8-B48F-1D18A9856A87
  last_name: Novarino
  orcid: 0000-0002-7673-7178
citation:
  ama: Dotter C, Novarino G. Supplementary data for the research paper “Haploinsufficiency
    of the intellectual disability gene SETD5 disturbs developmental gene expression
    and cognition.” 2019. doi:<a href="https://doi.org/10.15479/AT:ISTA:6074">10.15479/AT:ISTA:6074</a>
  apa: Dotter, C., &#38; Novarino, G. (2019). Supplementary data for the research
    paper “Haploinsufficiency of the intellectual disability gene SETD5 disturbs developmental
    gene expression and cognition.” Institute of Science and Technology Austria. <a
    href="https://doi.org/10.15479/AT:ISTA:6074">https://doi.org/10.15479/AT:ISTA:6074</a>
  chicago: Dotter, Christoph, and Gaia Novarino. “Supplementary Data for the Research
    Paper ‘Haploinsufficiency of the Intellectual Disability Gene SETD5 Disturbs Developmental
    Gene Expression and Cognition.’” Institute of Science and Technology Austria,
    2019. <a href="https://doi.org/10.15479/AT:ISTA:6074">https://doi.org/10.15479/AT:ISTA:6074</a>.
  ieee: C. Dotter and G. Novarino, “Supplementary data for the research paper ‘Haploinsufficiency
    of the intellectual disability gene SETD5 disturbs developmental gene expression
    and cognition.’” Institute of Science and Technology Austria, 2019.
  ista: Dotter C, Novarino G. 2019. Supplementary data for the research paper ‘Haploinsufficiency
    of the intellectual disability gene SETD5 disturbs developmental gene expression
    and cognition’, Institute of Science and Technology Austria, <a href="https://doi.org/10.15479/AT:ISTA:6074">10.15479/AT:ISTA:6074</a>.
  mla: Dotter, Christoph, and Gaia Novarino. <i>Supplementary Data for the Research
    Paper “Haploinsufficiency of the Intellectual Disability Gene SETD5 Disturbs Developmental
    Gene Expression and Cognition.”</i> Institute of Science and Technology Austria,
    2019, doi:<a href="https://doi.org/10.15479/AT:ISTA:6074">10.15479/AT:ISTA:6074</a>.
  short: C. Dotter, G. Novarino, (2019).
date_created: 2019-03-07T13:32:35Z
date_published: 2019-01-09T00:00:00Z
date_updated: 2024-02-21T13:41:01Z
day: '09'
ddc:
- '570'
department:
- _id: GaNo
doi: 10.15479/AT:ISTA:6074
file:
- access_level: open_access
  checksum: bc1b285edca9e98a2c63d153c79bb75b
  content_type: application/zip
  creator: dernst
  date_created: 2019-03-07T13:37:19Z
  date_updated: 2020-07-14T12:47:18Z
  file_id: '6084'
  file_name: Setd5_paper.zip
  file_size: 33202743
  relation: supplementary_material
file_date_updated: 2020-07-14T12:47:18Z
has_accepted_license: '1'
month: '01'
oa: 1
oa_version: Published Version
publisher: Institute of Science and Technology Austria
related_material:
  record:
  - id: '3'
    relation: research_paper
    status: public
status: public
title: Supplementary data for the research paper "Haploinsufficiency of the intellectual
  disability gene SETD5 disturbs developmental gene expression and cognition"
type: research_data
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '2019'
...
---
_id: '6086'
abstract:
- lang: eng
  text: We show that linear analytic cocycles where all Lyapunov exponents are negative
    infinite are nilpotent. For such one-frequency cocycles we show that they can
    be analytically conjugated to an upper triangular cocycle or a Jordan normal form.
    As a consequence, an arbitrarily small analytic perturbation leads to distinct
    Lyapunov exponents. Moreover, in the one-frequency case where the th Lyapunov
    exponent is finite and the st negative infinite, we obtain a simple criterion
    for domination in which case there is a splitting into a nilpotent part and an
    invertible part.
article_processing_charge: No
arxiv: 1
author:
- first_name: Christian
  full_name: Sadel, Christian
  id: 4760E9F8-F248-11E8-B48F-1D18A9856A87
  last_name: Sadel
  orcid: 0000-0001-8255-3968
- first_name: Disheng
  full_name: Xu, Disheng
  last_name: Xu
citation:
  ama: Sadel C, Xu D. Singular analytic linear cocycles with negative infinite Lyapunov
    exponents. <i>Ergodic Theory and Dynamical Systems</i>. 2019;39(4):1082-1098.
    doi:<a href="https://doi.org/10.1017/etds.2017.52">10.1017/etds.2017.52</a>
  apa: Sadel, C., &#38; Xu, D. (2019). Singular analytic linear cocycles with negative
    infinite Lyapunov exponents. <i>Ergodic Theory and Dynamical Systems</i>. Cambridge
    University Press. <a href="https://doi.org/10.1017/etds.2017.52">https://doi.org/10.1017/etds.2017.52</a>
  chicago: Sadel, Christian, and Disheng Xu. “Singular Analytic Linear Cocycles with
    Negative Infinite Lyapunov Exponents.” <i>Ergodic Theory and Dynamical Systems</i>.
    Cambridge University Press, 2019. <a href="https://doi.org/10.1017/etds.2017.52">https://doi.org/10.1017/etds.2017.52</a>.
  ieee: C. Sadel and D. Xu, “Singular analytic linear cocycles with negative infinite
    Lyapunov exponents,” <i>Ergodic Theory and Dynamical Systems</i>, vol. 39, no.
    4. Cambridge University Press, pp. 1082–1098, 2019.
  ista: Sadel C, Xu D. 2019. Singular analytic linear cocycles with negative infinite
    Lyapunov exponents. Ergodic Theory and Dynamical Systems. 39(4), 1082–1098.
  mla: Sadel, Christian, and Disheng Xu. “Singular Analytic Linear Cocycles with Negative
    Infinite Lyapunov Exponents.” <i>Ergodic Theory and Dynamical Systems</i>, vol.
    39, no. 4, Cambridge University Press, 2019, pp. 1082–98, doi:<a href="https://doi.org/10.1017/etds.2017.52">10.1017/etds.2017.52</a>.
  short: C. Sadel, D. Xu, Ergodic Theory and Dynamical Systems 39 (2019) 1082–1098.
date_created: 2019-03-10T22:59:18Z
date_published: 2019-04-01T00:00:00Z
date_updated: 2023-08-25T08:03:30Z
day: '01'
department:
- _id: LaEr
doi: 10.1017/etds.2017.52
ec_funded: 1
external_id:
  arxiv:
  - '1601.06118'
  isi:
  - '000459725600012'
intvolume: '        39'
isi: 1
issue: '4'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://arxiv.org/abs/1601.06118
month: '04'
oa: 1
oa_version: Preprint
page: 1082-1098
project:
- _id: 25681D80-B435-11E9-9278-68D0E5697425
  call_identifier: FP7
  grant_number: '291734'
  name: International IST Postdoc Fellowship Programme
publication: Ergodic Theory and Dynamical Systems
publication_status: published
publisher: Cambridge University Press
quality_controlled: '1'
scopus_import: '1'
status: public
title: Singular analytic linear cocycles with negative infinite Lyapunov exponents
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 39
year: '2019'
...
---
_id: '6087'
abstract:
- lang: eng
  text: Cell fate specification by lateral inhibition typically involves contact signaling
    through the Delta-Notch signaling pathway. However, whether this is the only signaling
    mode mediating lateral inhibition remains unclear. Here we show that in zebrafish
    oogenesis, a group of cells within the granulosa cell layer at the oocyte animal
    pole acquire elevated levels of the transcriptional coactivator TAZ in their nuclei.
    One of these cells, the future micropyle precursor cell (MPC), accumulates increasingly
    high levels of nuclear TAZ and grows faster than its surrounding cells, mechanically
    compressing those cells, which ultimately lose TAZ from their nuclei. Strikingly,
    relieving neighbor-cell compression by MPC ablation or aspiration restores nuclear
    TAZ accumulation in neighboring cells, eventually leading to MPC re-specification
    from these cells. Conversely, MPC specification is defective in taz−/− follicles.
    These findings uncover a novel mode of lateral inhibition in cell fate specification
    based on mechanical signals controlling TAZ activity.
acknowledged_ssus:
- _id: Bio
- _id: EM-Fac
- _id: LifeSc
acknowledgement: We thank Roland Dosch, Makoto Furutani-Seiki, Brian Link, Mary Mullins,
  and Masazumi Tada for providing transgenic and/or mutant zebrafish lines; Alexandra
  Schauer, Shayan Shami-Pour, and the rest of the Heisenberg lab for technical assistance
  and feedback on the manuscript; and the Bioimaging, Electron Microscopy, and Zebrafish
  facilities of IST Austria for continuous support. This work was supported by an
  ERC advanced grant ( MECSPEC to C.-P.H.).
article_processing_charge: No
article_type: original
author:
- first_name: Peng
  full_name: Xia, Peng
  id: 4AB6C7D0-F248-11E8-B48F-1D18A9856A87
  last_name: Xia
  orcid: 0000-0002-5419-7756
- first_name: Daniel J
  full_name: Gütl, Daniel J
  id: 381929CE-F248-11E8-B48F-1D18A9856A87
  last_name: Gütl
- first_name: Vanessa
  full_name: Zheden, Vanessa
  id: 39C5A68A-F248-11E8-B48F-1D18A9856A87
  last_name: Zheden
  orcid: 0000-0002-9438-4783
- first_name: Carl-Philipp J
  full_name: Heisenberg, Carl-Philipp J
  id: 39427864-F248-11E8-B48F-1D18A9856A87
  last_name: Heisenberg
  orcid: 0000-0002-0912-4566
citation:
  ama: Xia P, Gütl DJ, Zheden V, Heisenberg C-PJ. Lateral inhibition in cell specification
    mediated by mechanical signals modulating TAZ activity. <i>Cell</i>. 2019;176(6):1379-1392.e14.
    doi:<a href="https://doi.org/10.1016/j.cell.2019.01.019">10.1016/j.cell.2019.01.019</a>
  apa: Xia, P., Gütl, D. J., Zheden, V., &#38; Heisenberg, C.-P. J. (2019). Lateral
    inhibition in cell specification mediated by mechanical signals modulating TAZ
    activity. <i>Cell</i>. Elsevier. <a href="https://doi.org/10.1016/j.cell.2019.01.019">https://doi.org/10.1016/j.cell.2019.01.019</a>
  chicago: Xia, Peng, Daniel J Gütl, Vanessa Zheden, and Carl-Philipp J Heisenberg.
    “Lateral Inhibition in Cell Specification Mediated by Mechanical Signals Modulating
    TAZ Activity.” <i>Cell</i>. Elsevier, 2019. <a href="https://doi.org/10.1016/j.cell.2019.01.019">https://doi.org/10.1016/j.cell.2019.01.019</a>.
  ieee: P. Xia, D. J. Gütl, V. Zheden, and C.-P. J. Heisenberg, “Lateral inhibition
    in cell specification mediated by mechanical signals modulating TAZ activity,”
    <i>Cell</i>, vol. 176, no. 6. Elsevier, p. 1379–1392.e14, 2019.
  ista: Xia P, Gütl DJ, Zheden V, Heisenberg C-PJ. 2019. Lateral inhibition in cell
    specification mediated by mechanical signals modulating TAZ activity. Cell. 176(6),
    1379–1392.e14.
  mla: Xia, Peng, et al. “Lateral Inhibition in Cell Specification Mediated by Mechanical
    Signals Modulating TAZ Activity.” <i>Cell</i>, vol. 176, no. 6, Elsevier, 2019,
    p. 1379–1392.e14, doi:<a href="https://doi.org/10.1016/j.cell.2019.01.019">10.1016/j.cell.2019.01.019</a>.
  short: P. Xia, D.J. Gütl, V. Zheden, C.-P.J. Heisenberg, Cell 176 (2019) 1379–1392.e14.
date_created: 2019-03-10T22:59:19Z
date_published: 2019-03-07T00:00:00Z
date_updated: 2023-08-25T08:02:23Z
day: '07'
department:
- _id: CaHe
- _id: EM-Fac
doi: 10.1016/j.cell.2019.01.019
ec_funded: 1
external_id:
  isi:
  - '000460509600013'
  pmid:
  - '30773315'
intvolume: '       176'
isi: 1
issue: '6'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://doi.org/10.1016/j.cell.2019.01.019
month: '03'
oa: 1
oa_version: Published Version
page: 1379-1392.e14
pmid: 1
project:
- _id: 260F1432-B435-11E9-9278-68D0E5697425
  call_identifier: H2020
  grant_number: '742573'
  name: Interaction and feedback between cell mechanics and fate specification in
    vertebrate gastrulation
publication: Cell
publication_status: published
publisher: Elsevier
quality_controlled: '1'
related_material:
  link:
  - description: News on IST Homepage
    relation: press_release
    url: https://ist.ac.at/en/news/in-zebrafish-eggs-most-rapidly-growing-cell-inhibits-its-neighbours-through-mechanical-signals/
scopus_import: '1'
status: public
title: Lateral inhibition in cell specification mediated by mechanical signals modulating
  TAZ activity
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 176
year: '2019'
...
---
_id: '6088'
abstract:
- lang: eng
  text: P-Glycoprotein (ABCB1) and breast cancer resistance protein (ABCG2) are two
    efflux transporters at the blood–brain barrier (BBB), which effectively restrict
    brain distribution of diverse drugs, such as tyrosine kinase inhibitors. There
    is a crucial need for pharmacological ABCB1 and ABCG2 inhibition protocols for
    a more effective treatment of brain diseases. In the present study, seven marketed
    drugs (osimertinib, erlotinib, nilotinib, imatinib, lapatinib, pazopanib, and
    cyclosporine A) and one nonmarketed drug (tariquidar), with known in vitro ABCB1/ABCG2
    inhibitory properties, were screened for their inhibitory potency at the BBB in
    vivo. Positron emission tomography (PET) using the model ABCB1/ABCG2 substrate
    [11C]erlotinib was performed in mice. Tested inhibitors were administered as i.v.
    bolus injections at 30 min before the start of the PET scan, followed by a continuous
    i.v. infusion for the duration of the PET scan. Five of the tested drugs increased
    total distribution volume of [11C]erlotinib in the brain (VT,brain) compared to
    vehicle-treated animals (tariquidar, + 69%; erlotinib, + 19% and +23% for the
    21.5 mg/kg and the 43 mg/kg dose, respectively; imatinib, + 22%; lapatinib, +
    25%; and cyclosporine A, + 49%). For all drugs, increases in [11C]erlotinib brain
    distribution were lower than in Abcb1a/b(−/−)Abcg2(−/−) mice (+149%), which suggested
    that only partial ABCB1/ABCG2 inhibition was reached at the mouse BBB. The plasma
    concentrations of the tested drugs at the time of the PET scan were higher than
    clinically achievable plasma concentrations. Some of the tested drugs led to significant
    increases in blood radioactivity concentrations measured at the end of the PET
    scan (erlotinib, + 103% and +113% for the 21.5 mg/kg and the 43 mg/kg dose, respectively;
    imatinib, + 125%; and cyclosporine A, + 101%), which was most likely caused by
    decreased hepatobiliary excretion of radioactivity. Taken together, our data suggest
    that some marketed tyrosine kinase inhibitors may be repurposed to inhibit ABCB1
    and ABCG2 at the BBB. From a clinical perspective, moderate increases in brain
    delivery despite the administration of high i.v. doses as well as peripheral drug–drug
    interactions due to transporter inhibition in clearance organs question the translatability
    of this concept.
article_processing_charge: No
author:
- first_name: Alexander
  full_name: Traxl, Alexander
  last_name: Traxl
- first_name: Severin
  full_name: Mairinger, Severin
  last_name: Mairinger
- first_name: Thomas
  full_name: Filip, Thomas
  last_name: Filip
- first_name: Michael
  full_name: Sauberer, Michael
  last_name: Sauberer
- first_name: Johann
  full_name: Stanek, Johann
  last_name: Stanek
- first_name: Stefan
  full_name: Poschner, Stefan
  last_name: Poschner
- first_name: Walter
  full_name: Jäger, Walter
  last_name: Jäger
- first_name: Viktoria
  full_name: Zoufal, Viktoria
  last_name: Zoufal
- first_name: Gaia
  full_name: Novarino, Gaia
  id: 3E57A680-F248-11E8-B48F-1D18A9856A87
  last_name: Novarino
  orcid: 0000-0002-7673-7178
- first_name: Nicolas
  full_name: Tournier, Nicolas
  last_name: Tournier
- first_name: Martin
  full_name: Bauer, Martin
  last_name: Bauer
- first_name: Thomas
  full_name: Wanek, Thomas
  last_name: Wanek
- first_name: Oliver
  full_name: Langer, Oliver
  last_name: Langer
citation:
  ama: Traxl A, Mairinger S, Filip T, et al. Inhibition of ABCB1 and ABCG2 at the
    mouse blood-brain barrier with marketed drugs to improve brain delivery of the
    model ABCB1/ABCG2 substrate [11C]erlotinib. <i>Molecular Pharmaceutics</i>. 2019;16(3):1282-1293.
    doi:<a href="https://doi.org/10.1021/acs.molpharmaceut.8b01217">10.1021/acs.molpharmaceut.8b01217</a>
  apa: Traxl, A., Mairinger, S., Filip, T., Sauberer, M., Stanek, J., Poschner, S.,
    … Langer, O. (2019). Inhibition of ABCB1 and ABCG2 at the mouse blood-brain barrier
    with marketed drugs to improve brain delivery of the model ABCB1/ABCG2 substrate
    [11C]erlotinib. <i>Molecular Pharmaceutics</i>. American Chemical Society. <a
    href="https://doi.org/10.1021/acs.molpharmaceut.8b01217">https://doi.org/10.1021/acs.molpharmaceut.8b01217</a>
  chicago: Traxl, Alexander, Severin Mairinger, Thomas Filip, Michael Sauberer, Johann
    Stanek, Stefan Poschner, Walter Jäger, et al. “Inhibition of ABCB1 and ABCG2 at
    the Mouse Blood-Brain Barrier with Marketed Drugs to Improve Brain Delivery of
    the Model ABCB1/ABCG2 Substrate [11C]Erlotinib.” <i>Molecular Pharmaceutics</i>.
    American Chemical Society, 2019. <a href="https://doi.org/10.1021/acs.molpharmaceut.8b01217">https://doi.org/10.1021/acs.molpharmaceut.8b01217</a>.
  ieee: A. Traxl <i>et al.</i>, “Inhibition of ABCB1 and ABCG2 at the mouse blood-brain
    barrier with marketed drugs to improve brain delivery of the model ABCB1/ABCG2
    substrate [11C]erlotinib,” <i>Molecular Pharmaceutics</i>, vol. 16, no. 3. American
    Chemical Society, pp. 1282–1293, 2019.
  ista: Traxl A, Mairinger S, Filip T, Sauberer M, Stanek J, Poschner S, Jäger W,
    Zoufal V, Novarino G, Tournier N, Bauer M, Wanek T, Langer O. 2019. Inhibition
    of ABCB1 and ABCG2 at the mouse blood-brain barrier with marketed drugs to improve
    brain delivery of the model ABCB1/ABCG2 substrate [11C]erlotinib. Molecular Pharmaceutics.
    16(3), 1282–1293.
  mla: Traxl, Alexander, et al. “Inhibition of ABCB1 and ABCG2 at the Mouse Blood-Brain
    Barrier with Marketed Drugs to Improve Brain Delivery of the Model ABCB1/ABCG2
    Substrate [11C]Erlotinib.” <i>Molecular Pharmaceutics</i>, vol. 16, no. 3, American
    Chemical Society, 2019, pp. 1282–93, doi:<a href="https://doi.org/10.1021/acs.molpharmaceut.8b01217">10.1021/acs.molpharmaceut.8b01217</a>.
  short: A. Traxl, S. Mairinger, T. Filip, M. Sauberer, J. Stanek, S. Poschner, W.
    Jäger, V. Zoufal, G. Novarino, N. Tournier, M. Bauer, T. Wanek, O. Langer, Molecular
    Pharmaceutics 16 (2019) 1282–1293.
date_created: 2019-03-10T22:59:19Z
date_published: 2019-03-04T00:00:00Z
date_updated: 2023-08-25T08:02:51Z
day: '04'
department:
- _id: GaNo
doi: 10.1021/acs.molpharmaceut.8b01217
external_id:
  isi:
  - '000460600400031'
  pmid:
  - '30694684'
intvolume: '        16'
isi: 1
issue: '3'
language:
- iso: eng
month: '03'
oa_version: None
page: 1282-1293
pmid: 1
publication: Molecular Pharmaceutics
publication_status: published
publisher: American Chemical Society
quality_controlled: '1'
scopus_import: '1'
status: public
title: Inhibition of ABCB1 and ABCG2 at the mouse blood-brain barrier with marketed
  drugs to improve brain delivery of the model ABCB1/ABCG2 substrate [11C]erlotinib
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 16
year: '2019'
...
---
_id: '6089'
abstract:
- lang: eng
  text: Pleiotropy is the well-established idea that a single mutation affects multiple
    phenotypes. If a mutation has opposite effects on fitness when expressed in different
    contexts, then genetic conflict arises. Pleiotropic conflict is expected to reduce
    the efficacy of selection by limiting the fixation of beneficial mutations through
    adaptation, and the removal of deleterious mutations through purifying selection.
    Although this has been widely discussed, in particular in the context of a putative
    “gender load,” it has yet to be systematically quantified. In this work, we empirically
    estimate to which extent different pleiotropic regimes impede the efficacy of
    selection in Drosophila melanogaster. We use whole-genome polymorphism data from
    a single African population and divergence data from D. simulans to estimate the
    fraction of adaptive fixations (α), the rate of adaptation (ωA), and the direction
    of selection (DoS). After controlling for confounding covariates, we find that
    the different pleiotropic regimes have a relatively small, but significant, effect
    on selection efficacy. Specifically, our results suggest that pleiotropic sexual
    antagonism may restrict the efficacy of selection, but that this conflict can
    be resolved by limiting the expression of genes to the sex where they are beneficial.
    Intermediate levels of pleiotropy across tissues and life stages can also lead
    to maladaptation in D. melanogaster, due to inefficient purifying selection combined
    with low frequency of mutations that confer a selective advantage. Thus, our study
    highlights the need to consider the efficacy of selection in the context of antagonistic
    pleiotropy, and of genetic conflict in general.
article_processing_charge: No
author:
- first_name: Christelle
  full_name: Fraisse, Christelle
  id: 32DF5794-F248-11E8-B48F-1D18A9856A87
  last_name: Fraisse
  orcid: 0000-0001-8441-5075
- first_name: Gemma
  full_name: Puixeu Sala, Gemma
  id: 33AB266C-F248-11E8-B48F-1D18A9856A87
  last_name: Puixeu Sala
  orcid: 0000-0001-8330-1754
- first_name: Beatriz
  full_name: Vicoso, Beatriz
  id: 49E1C5C6-F248-11E8-B48F-1D18A9856A87
  last_name: Vicoso
  orcid: 0000-0002-4579-8306
citation:
  ama: Fraisse C, Puixeu Sala G, Vicoso B. Pleiotropy modulates the efficacy of selection
    in drosophila melanogaster. <i>Molecular biology and evolution</i>. 2019;36(3):500-515.
    doi:<a href="https://doi.org/10.1093/molbev/msy246">10.1093/molbev/msy246</a>
  apa: Fraisse, C., Puixeu Sala, G., &#38; Vicoso, B. (2019). Pleiotropy modulates
    the efficacy of selection in drosophila melanogaster. <i>Molecular Biology and
    Evolution</i>. Oxford University Press. <a href="https://doi.org/10.1093/molbev/msy246">https://doi.org/10.1093/molbev/msy246</a>
  chicago: Fraisse, Christelle, Gemma Puixeu Sala, and Beatriz Vicoso. “Pleiotropy
    Modulates the Efficacy of Selection in Drosophila Melanogaster.” <i>Molecular
    Biology and Evolution</i>. Oxford University Press, 2019. <a href="https://doi.org/10.1093/molbev/msy246">https://doi.org/10.1093/molbev/msy246</a>.
  ieee: C. Fraisse, G. Puixeu Sala, and B. Vicoso, “Pleiotropy modulates the efficacy
    of selection in drosophila melanogaster,” <i>Molecular biology and evolution</i>,
    vol. 36, no. 3. Oxford University Press, pp. 500–515, 2019.
  ista: Fraisse C, Puixeu Sala G, Vicoso B. 2019. Pleiotropy modulates the efficacy
    of selection in drosophila melanogaster. Molecular biology and evolution. 36(3),
    500–515.
  mla: Fraisse, Christelle, et al. “Pleiotropy Modulates the Efficacy of Selection
    in Drosophila Melanogaster.” <i>Molecular Biology and Evolution</i>, vol. 36,
    no. 3, Oxford University Press, 2019, pp. 500–15, doi:<a href="https://doi.org/10.1093/molbev/msy246">10.1093/molbev/msy246</a>.
  short: C. Fraisse, G. Puixeu Sala, B. Vicoso, Molecular Biology and Evolution 36
    (2019) 500–515.
date_created: 2019-03-10T22:59:19Z
date_published: 2019-03-01T00:00:00Z
date_updated: 2024-02-21T13:59:17Z
day: '01'
department:
- _id: BeVi
- _id: NiBa
doi: 10.1093/molbev/msy246
external_id:
  isi:
  - '000462585100006'
  pmid:
  - '30590559'
intvolume: '        36'
isi: 1
issue: '3'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://www.ncbi.nlm.nih.gov/pubmed/30590559
month: '03'
oa: 1
oa_version: Submitted Version
page: 500-515
pmid: 1
project:
- _id: 250ED89C-B435-11E9-9278-68D0E5697425
  call_identifier: FWF
  grant_number: P28842-B22
  name: Sex chromosome evolution under male- and female- heterogamety
publication: Molecular biology and evolution
publication_identifier:
  eissn:
  - 1537-1719
  issn:
  - 0737-4038
publication_status: published
publisher: Oxford University Press
quality_controlled: '1'
related_material:
  record:
  - id: '5757'
    relation: popular_science
    status: public
scopus_import: '1'
status: public
title: Pleiotropy modulates the efficacy of selection in drosophila melanogaster
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 36
year: '2019'
...
---
_id: '6090'
abstract:
- lang: eng
  text: Cells need to reliably sense external ligand concentrations to achieve various
    biological functions such as chemotaxis or signaling. The molecular recognition
    of ligands by surface receptors is degenerate in many systems, leading to crosstalk
    between ligand-receptor pairs. Crosstalk is often thought of as a deviation from
    optimal specific recognition, as the binding of noncognate ligands can interfere
    with the detection of the receptor's cognate ligand, possibly leading to a false
    triggering of a downstream signaling pathway. Here we quantify the optimal precision
    of sensing the concentrations of multiple ligands by a collection of promiscuous
    receptors. We demonstrate that crosstalk can improve precision in concentration
    sensing and discrimination tasks. To achieve superior precision, the additional
    information about ligand concentrations contained in short binding events of the
    noncognate ligand should be exploited. We present a proofreading scheme to realize
    an approximate estimation of multiple ligand concentrations that reaches a precision
    close to the derived optimal bounds. Our results help rationalize the observed
    ubiquity of receptor crosstalk in molecular sensing.
article_number: '022423'
article_processing_charge: No
author:
- first_name: Martín
  full_name: Carballo-Pacheco, Martín
  last_name: Carballo-Pacheco
- first_name: Jonathan
  full_name: Desponds, Jonathan
  last_name: Desponds
- first_name: Tatyana
  full_name: Gavrilchenko, Tatyana
  last_name: Gavrilchenko
- first_name: Andreas
  full_name: Mayer, Andreas
  last_name: Mayer
- first_name: Roshan
  full_name: Prizak, Roshan
  id: 4456104E-F248-11E8-B48F-1D18A9856A87
  last_name: Prizak
- first_name: Gautam
  full_name: Reddy, Gautam
  last_name: Reddy
- first_name: Ilya
  full_name: Nemenman, Ilya
  last_name: Nemenman
- first_name: Thierry
  full_name: Mora, Thierry
  last_name: Mora
citation:
  ama: Carballo-Pacheco M, Desponds J, Gavrilchenko T, et al. Receptor crosstalk improves
    concentration sensing of multiple ligands. <i>Physical Review E</i>. 2019;99(2).
    doi:<a href="https://doi.org/10.1103/PhysRevE.99.022423">10.1103/PhysRevE.99.022423</a>
  apa: Carballo-Pacheco, M., Desponds, J., Gavrilchenko, T., Mayer, A., Prizak, R.,
    Reddy, G., … Mora, T. (2019). Receptor crosstalk improves concentration sensing
    of multiple ligands. <i>Physical Review E</i>. American Physical Society. <a href="https://doi.org/10.1103/PhysRevE.99.022423">https://doi.org/10.1103/PhysRevE.99.022423</a>
  chicago: Carballo-Pacheco, Martín, Jonathan Desponds, Tatyana Gavrilchenko, Andreas
    Mayer, Roshan Prizak, Gautam Reddy, Ilya Nemenman, and Thierry Mora. “Receptor
    Crosstalk Improves Concentration Sensing of Multiple Ligands.” <i>Physical Review
    E</i>. American Physical Society, 2019. <a href="https://doi.org/10.1103/PhysRevE.99.022423">https://doi.org/10.1103/PhysRevE.99.022423</a>.
  ieee: M. Carballo-Pacheco <i>et al.</i>, “Receptor crosstalk improves concentration
    sensing of multiple ligands,” <i>Physical Review E</i>, vol. 99, no. 2. American
    Physical Society, 2019.
  ista: Carballo-Pacheco M, Desponds J, Gavrilchenko T, Mayer A, Prizak R, Reddy G,
    Nemenman I, Mora T. 2019. Receptor crosstalk improves concentration sensing of
    multiple ligands. Physical Review E. 99(2), 022423.
  mla: Carballo-Pacheco, Martín, et al. “Receptor Crosstalk Improves Concentration
    Sensing of Multiple Ligands.” <i>Physical Review E</i>, vol. 99, no. 2, 022423,
    American Physical Society, 2019, doi:<a href="https://doi.org/10.1103/PhysRevE.99.022423">10.1103/PhysRevE.99.022423</a>.
  short: M. Carballo-Pacheco, J. Desponds, T. Gavrilchenko, A. Mayer, R. Prizak, G.
    Reddy, I. Nemenman, T. Mora, Physical Review E 99 (2019).
date_created: 2019-03-10T22:59:20Z
date_published: 2019-02-26T00:00:00Z
date_updated: 2024-02-28T13:12:06Z
day: '26'
department:
- _id: NiBa
- _id: GaTk
doi: 10.1103/PhysRevE.99.022423
external_id:
  isi:
  - '000459916500007'
intvolume: '        99'
isi: 1
issue: '2'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://www.biorxiv.org/content/10.1101/448118v1.abstract
month: '02'
oa: 1
oa_version: Preprint
publication: Physical Review E
publication_status: published
publisher: American Physical Society
quality_controlled: '1'
scopus_import: '1'
status: public
title: Receptor crosstalk improves concentration sensing of multiple ligands
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 99
year: '2019'
...
---
_id: '6091'
abstract:
- lang: eng
  text: Cortical networks are characterized by sparse connectivity, with synapses
    found at only a subset of axo-dendritic contacts. Yet within these networks, neurons
    can exhibit high connection probabilities, suggesting that cell-intrinsic factors,
    not proximity, determine connectivity. Here, we identify ephrin-B3 (eB3) as a
    factor that determines synapse density by mediating a cell-cell competition that
    requires ephrin-B-EphB signaling. In a microisland culture system designed to
    isolate cell-cell competition, we find that eB3 determines winning and losing
    neurons in a contest for synapses. In a Mosaic Analysis with Double Markers (MADM)
    genetic mouse model system in vivo the relative levels of eB3 control spine density
    in layer 5 and 6 neurons. MADM cortical neurons in vitro reveal that eB3 controls
    synapse density independently of action potential-driven activity. Our findings
    illustrate a new class of competitive mechanism mediated by trans-synaptic organizing
    proteins which control the number of synapses neurons receive relative to neighboring
    neurons.
article_number: e41563
article_processing_charge: No
author:
- first_name: Nathan T.
  full_name: Henderson, Nathan T.
  last_name: Henderson
- first_name: Sylvain J.
  full_name: Le Marchand, Sylvain J.
  last_name: Le Marchand
- first_name: Martin
  full_name: Hruska, Martin
  last_name: Hruska
- first_name: Simon
  full_name: Hippenmeyer, Simon
  id: 37B36620-F248-11E8-B48F-1D18A9856A87
  last_name: Hippenmeyer
  orcid: 0000-0003-2279-1061
- first_name: Liqun
  full_name: Luo, Liqun
  last_name: Luo
- first_name: Matthew B.
  full_name: Dalva, Matthew B.
  last_name: Dalva
citation:
  ama: Henderson NT, Le Marchand SJ, Hruska M, Hippenmeyer S, Luo L, Dalva MB. Ephrin-B3
    controls excitatory synapse density through cell-cell competition for EphBs. <i>eLife</i>.
    2019;8. doi:<a href="https://doi.org/10.7554/eLife.41563">10.7554/eLife.41563</a>
  apa: Henderson, N. T., Le Marchand, S. J., Hruska, M., Hippenmeyer, S., Luo, L.,
    &#38; Dalva, M. B. (2019). Ephrin-B3 controls excitatory synapse density through
    cell-cell competition for EphBs. <i>ELife</i>. eLife Sciences Publications. <a
    href="https://doi.org/10.7554/eLife.41563">https://doi.org/10.7554/eLife.41563</a>
  chicago: Henderson, Nathan T., Sylvain J. Le Marchand, Martin Hruska, Simon Hippenmeyer,
    Liqun Luo, and Matthew B. Dalva. “Ephrin-B3 Controls Excitatory Synapse Density
    through Cell-Cell Competition for EphBs.” <i>ELife</i>. eLife Sciences Publications,
    2019. <a href="https://doi.org/10.7554/eLife.41563">https://doi.org/10.7554/eLife.41563</a>.
  ieee: N. T. Henderson, S. J. Le Marchand, M. Hruska, S. Hippenmeyer, L. Luo, and
    M. B. Dalva, “Ephrin-B3 controls excitatory synapse density through cell-cell
    competition for EphBs,” <i>eLife</i>, vol. 8. eLife Sciences Publications, 2019.
  ista: Henderson NT, Le Marchand SJ, Hruska M, Hippenmeyer S, Luo L, Dalva MB. 2019.
    Ephrin-B3 controls excitatory synapse density through cell-cell competition for
    EphBs. eLife. 8, e41563.
  mla: Henderson, Nathan T., et al. “Ephrin-B3 Controls Excitatory Synapse Density
    through Cell-Cell Competition for EphBs.” <i>ELife</i>, vol. 8, e41563, eLife
    Sciences Publications, 2019, doi:<a href="https://doi.org/10.7554/eLife.41563">10.7554/eLife.41563</a>.
  short: N.T. Henderson, S.J. Le Marchand, M. Hruska, S. Hippenmeyer, L. Luo, M.B.
    Dalva, ELife 8 (2019).
date_created: 2019-03-10T22:59:20Z
date_published: 2019-02-21T00:00:00Z
date_updated: 2023-08-24T14:50:50Z
day: '21'
ddc:
- '570'
department:
- _id: SiHi
doi: 10.7554/eLife.41563
external_id:
  isi:
  - '000459380600001'
  pmid:
  - '30789343'
file:
- access_level: open_access
  checksum: 7b0800d003f14cd06b1802dea0c52941
  content_type: application/pdf
  creator: dernst
  date_created: 2019-03-11T16:15:37Z
  date_updated: 2020-07-14T12:47:19Z
  file_id: '6098'
  file_name: 2019_eLife_Henderson.pdf
  file_size: 7260753
  relation: main_file
file_date_updated: 2020-07-14T12:47:19Z
has_accepted_license: '1'
intvolume: '         8'
isi: 1
language:
- iso: eng
month: '02'
oa: 1
oa_version: Published Version
pmid: 1
publication: eLife
publication_status: published
publisher: eLife Sciences Publications
quality_controlled: '1'
scopus_import: '1'
status: public
title: Ephrin-B3 controls excitatory synapse density through cell-cell competition
  for EphBs
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 8
year: '2019'
...
---
_id: '6092'
abstract:
- lang: eng
  text: In 1915, Einstein and de Haas and Barnett demonstrated that changing the magnetization
    of a magnetic material results in mechanical rotation and vice versa. At the microscopic
    level, this effect governs the transfer between electron spin and orbital angular
    momentum, and lattice degrees of freedom, understanding which is key for molecular
    magnets, nano-magneto-mechanics, spintronics, and ultrafast magnetism. Until now,
    the timescales of electron-to-lattice angular momentum transfer remain unclear,
    since modeling this process on a microscopic level requires the addition of an
    infinite amount of quantum angular momenta. We show that this problem can be solved
    by reformulating it in terms of the recently discovered angulon quasiparticles,
    which results in a rotationally invariant quantum many-body theory. In particular,
    we demonstrate that nonperturbative effects take place even if the electron-phonon
    coupling is weak and give rise to angular momentum transfer on femtosecond timescales.
article_number: '064428'
article_processing_charge: No
arxiv: 1
author:
- first_name: Johann H
  full_name: Mentink, Johann H
  last_name: Mentink
- first_name: Mikhail
  full_name: Katsnelson, Mikhail
  last_name: Katsnelson
- first_name: Mikhail
  full_name: Lemeshko, Mikhail
  id: 37CB05FA-F248-11E8-B48F-1D18A9856A87
  last_name: Lemeshko
  orcid: 0000-0002-6990-7802
citation:
  ama: Mentink JH, Katsnelson M, Lemeshko M. Quantum many-body dynamics of the Einstein-de
    Haas effect. <i>Physical Review B</i>. 2019;99(6). doi:<a href="https://doi.org/10.1103/PhysRevB.99.064428">10.1103/PhysRevB.99.064428</a>
  apa: Mentink, J. H., Katsnelson, M., &#38; Lemeshko, M. (2019). Quantum many-body
    dynamics of the Einstein-de Haas effect. <i>Physical Review B</i>. American Physical
    Society. <a href="https://doi.org/10.1103/PhysRevB.99.064428">https://doi.org/10.1103/PhysRevB.99.064428</a>
  chicago: Mentink, Johann H, Mikhail Katsnelson, and Mikhail Lemeshko. “Quantum Many-Body
    Dynamics of the Einstein-de Haas Effect.” <i>Physical Review B</i>. American Physical
    Society, 2019. <a href="https://doi.org/10.1103/PhysRevB.99.064428">https://doi.org/10.1103/PhysRevB.99.064428</a>.
  ieee: J. H. Mentink, M. Katsnelson, and M. Lemeshko, “Quantum many-body dynamics
    of the Einstein-de Haas effect,” <i>Physical Review B</i>, vol. 99, no. 6. American
    Physical Society, 2019.
  ista: Mentink JH, Katsnelson M, Lemeshko M. 2019. Quantum many-body dynamics of
    the Einstein-de Haas effect. Physical Review B. 99(6), 064428.
  mla: Mentink, Johann H., et al. “Quantum Many-Body Dynamics of the Einstein-de Haas
    Effect.” <i>Physical Review B</i>, vol. 99, no. 6, 064428, American Physical Society,
    2019, doi:<a href="https://doi.org/10.1103/PhysRevB.99.064428">10.1103/PhysRevB.99.064428</a>.
  short: J.H. Mentink, M. Katsnelson, M. Lemeshko, Physical Review B 99 (2019).
date_created: 2019-03-10T22:59:20Z
date_published: 2019-02-01T00:00:00Z
date_updated: 2024-02-28T13:11:54Z
day: '01'
department:
- _id: MiLe
doi: 10.1103/PhysRevB.99.064428
external_id:
  arxiv:
  - '1802.01638'
  isi:
  - '000459223400004'
intvolume: '        99'
isi: 1
issue: '6'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://arxiv.org/abs/1802.01638
month: '02'
oa: 1
oa_version: Preprint
project:
- _id: 26031614-B435-11E9-9278-68D0E5697425
  call_identifier: FWF
  grant_number: P29902
  name: Quantum rotations in the presence of a many-body environment
publication: Physical Review B
publication_status: published
publisher: American Physical Society
quality_controlled: '1'
scopus_import: '1'
status: public
title: Quantum many-body dynamics of the Einstein-de Haas effect
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 99
year: '2019'
...
---
_id: '6095'
abstract:
- lang: eng
  text: Both classical and recent studies suggest that chromosomal inversion polymorphisms
    are important in adaptation and speciation. However, biases in discovery and reporting
    of inversions make it difficult to assess their prevalence and biological importance.
    Here, we use an approach based on linkage disequilibrium among markers genotyped
    for samples collected across a transect between contrasting habitats to detect
    chromosomal rearrangements de novo. We report 17 polymorphic rearrangements in
    a single locality for the coastal marine snail, Littorina saxatilis. Patterns
    of diversity in the field and of recombination in controlled crosses provide strong
    evidence that at least the majority of these rearrangements are inversions. Most
    show clinal changes in frequency between habitats, suggestive of divergent selection,
    but only one appears to be fixed for different arrangements in the two habitats.
    Consistent with widespread evidence for balancing selection on inversion polymorphisms,
    we argue that a combination of heterosis and divergent selection can explain the
    observed patterns and should be considered in other systems spanning environmental
    gradients.
article_processing_charge: No
author:
- first_name: Rui
  full_name: Faria, Rui
  last_name: Faria
- first_name: Pragya
  full_name: Chaube, Pragya
  last_name: Chaube
- first_name: Hernán E.
  full_name: Morales, Hernán E.
  last_name: Morales
- first_name: Tomas
  full_name: Larsson, Tomas
  last_name: Larsson
- first_name: Alan R.
  full_name: Lemmon, Alan R.
  last_name: Lemmon
- first_name: Emily M.
  full_name: Lemmon, Emily M.
  last_name: Lemmon
- first_name: Marina
  full_name: Rafajlović, Marina
  last_name: Rafajlović
- first_name: Marina
  full_name: Panova, Marina
  last_name: Panova
- first_name: Mark
  full_name: Ravinet, Mark
  last_name: Ravinet
- first_name: Kerstin
  full_name: Johannesson, Kerstin
  last_name: Johannesson
- first_name: Anja M
  full_name: Westram, Anja M
  id: 3C147470-F248-11E8-B48F-1D18A9856A87
  last_name: Westram
  orcid: 0000-0003-1050-4969
- first_name: Roger K.
  full_name: Butlin, Roger K.
  last_name: Butlin
citation:
  ama: Faria R, Chaube P, Morales HE, et al. Multiple chromosomal rearrangements in
    a hybrid zone between Littorina saxatilis ecotypes. <i>Molecular Ecology</i>.
    2019;28(6):1375-1393. doi:<a href="https://doi.org/10.1111/mec.14972">10.1111/mec.14972</a>
  apa: Faria, R., Chaube, P., Morales, H. E., Larsson, T., Lemmon, A. R., Lemmon,
    E. M., … Butlin, R. K. (2019). Multiple chromosomal rearrangements in a hybrid
    zone between Littorina saxatilis ecotypes. <i>Molecular Ecology</i>. Wiley. <a
    href="https://doi.org/10.1111/mec.14972">https://doi.org/10.1111/mec.14972</a>
  chicago: Faria, Rui, Pragya Chaube, Hernán E. Morales, Tomas Larsson, Alan R. Lemmon,
    Emily M. Lemmon, Marina Rafajlović, et al. “Multiple Chromosomal Rearrangements
    in a Hybrid Zone between Littorina Saxatilis Ecotypes.” <i>Molecular Ecology</i>.
    Wiley, 2019. <a href="https://doi.org/10.1111/mec.14972">https://doi.org/10.1111/mec.14972</a>.
  ieee: R. Faria <i>et al.</i>, “Multiple chromosomal rearrangements in a hybrid zone
    between Littorina saxatilis ecotypes,” <i>Molecular Ecology</i>, vol. 28, no.
    6. Wiley, pp. 1375–1393, 2019.
  ista: Faria R, Chaube P, Morales HE, Larsson T, Lemmon AR, Lemmon EM, Rafajlović
    M, Panova M, Ravinet M, Johannesson K, Westram AM, Butlin RK. 2019. Multiple chromosomal
    rearrangements in a hybrid zone between Littorina saxatilis ecotypes. Molecular
    Ecology. 28(6), 1375–1393.
  mla: Faria, Rui, et al. “Multiple Chromosomal Rearrangements in a Hybrid Zone between
    Littorina Saxatilis Ecotypes.” <i>Molecular Ecology</i>, vol. 28, no. 6, Wiley,
    2019, pp. 1375–93, doi:<a href="https://doi.org/10.1111/mec.14972">10.1111/mec.14972</a>.
  short: R. Faria, P. Chaube, H.E. Morales, T. Larsson, A.R. Lemmon, E.M. Lemmon,
    M. Rafajlović, M. Panova, M. Ravinet, K. Johannesson, A.M. Westram, R.K. Butlin,
    Molecular Ecology 28 (2019) 1375–1393.
date_created: 2019-03-10T22:59:21Z
date_published: 2019-03-01T00:00:00Z
date_updated: 2023-08-24T14:50:27Z
day: '01'
ddc:
- '570'
department:
- _id: NiBa
doi: 10.1111/mec.14972
external_id:
  isi:
  - '000465219200013'
file:
- access_level: open_access
  checksum: f915885756057ec0ca5912a41f46a887
  content_type: application/pdf
  creator: dernst
  date_created: 2019-03-11T16:12:54Z
  date_updated: 2020-07-14T12:47:19Z
  file_id: '6097'
  file_name: 2019_MolecularEcology_Faria.pdf
  file_size: 1510715
  relation: main_file
file_date_updated: 2020-07-14T12:47:19Z
has_accepted_license: '1'
intvolume: '        28'
isi: 1
issue: '6'
language:
- iso: eng
month: '03'
oa: 1
oa_version: Published Version
page: 1375-1393
publication: Molecular Ecology
publication_identifier:
  eissn:
  - 1365-294X
  issn:
  - 0962-1083
publication_status: published
publisher: Wiley
quality_controlled: '1'
related_material:
  record:
  - id: '9837'
    relation: research_data
    status: public
scopus_import: '1'
status: public
title: Multiple chromosomal rearrangements in a hybrid zone between Littorina saxatilis
  ecotypes
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 28
year: '2019'
...
---
_id: '6102'
abstract:
- lang: eng
  text: 'Light is a union of electric and magnetic fields, and nowhere is the complex
    relationship between these fields more evident than in the near fields of nanophotonic
    structures. There, complicated electric and magnetic fields varying over subwavelength
    scales are generally present, which results in photonic phenomena such as extraordinary
    optical momentum, superchiral fields, and a complex spatial evolution of optical
    singularities. An understanding of such phenomena requires nanoscale measurements
    of the complete optical field vector. Although the sensitivity of near- field
    scanning optical microscopy to the complete electromagnetic field was recently
    demonstrated, a separation of different components required a priori knowledge
    of the sample. Here, we introduce a robust algorithm that can disentangle all
    six electric and magnetic field components from a single near-field measurement
    without any numerical modeling of the structure. As examples, we unravel the fields
    of two prototypical nanophotonic structures: a photonic crystal waveguide and
    a plasmonic nanowire. These results pave the way for new studies of complex photonic
    phenomena at the nanoscale and for the design of structures that optimize their
    optical behavior.'
article_number: '28'
article_processing_charge: No
arxiv: 1
author:
- first_name: B.
  full_name: Le Feber, B.
  last_name: Le Feber
- first_name: J. E.
  full_name: Sipe, J. E.
  last_name: Sipe
- first_name: Matthias
  full_name: Wulf, Matthias
  id: 45598606-F248-11E8-B48F-1D18A9856A87
  last_name: Wulf
  orcid: 0000-0001-6613-1378
- first_name: L.
  full_name: Kuipers, L.
  last_name: Kuipers
- first_name: N.
  full_name: Rotenberg, N.
  last_name: Rotenberg
citation:
  ama: 'Le Feber B, Sipe JE, Wulf M, Kuipers L, Rotenberg N. A full vectorial mapping
    of nanophotonic light fields. <i>Light: Science and Applications</i>. 2019;8(1).
    doi:<a href="https://doi.org/10.1038/s41377-019-0124-3">10.1038/s41377-019-0124-3</a>'
  apa: 'Le Feber, B., Sipe, J. E., Wulf, M., Kuipers, L., &#38; Rotenberg, N. (2019).
    A full vectorial mapping of nanophotonic light fields. <i>Light: Science and Applications</i>.
    Springer Nature. <a href="https://doi.org/10.1038/s41377-019-0124-3">https://doi.org/10.1038/s41377-019-0124-3</a>'
  chicago: 'Le Feber, B., J. E. Sipe, Matthias Wulf, L. Kuipers, and N. Rotenberg.
    “A Full Vectorial Mapping of Nanophotonic Light Fields.” <i>Light: Science and
    Applications</i>. Springer Nature, 2019. <a href="https://doi.org/10.1038/s41377-019-0124-3">https://doi.org/10.1038/s41377-019-0124-3</a>.'
  ieee: 'B. Le Feber, J. E. Sipe, M. Wulf, L. Kuipers, and N. Rotenberg, “A full vectorial
    mapping of nanophotonic light fields,” <i>Light: Science and Applications</i>,
    vol. 8, no. 1. Springer Nature, 2019.'
  ista: 'Le Feber B, Sipe JE, Wulf M, Kuipers L, Rotenberg N. 2019. A full vectorial
    mapping of nanophotonic light fields. Light: Science and Applications. 8(1), 28.'
  mla: 'Le Feber, B., et al. “A Full Vectorial Mapping of Nanophotonic Light Fields.”
    <i>Light: Science and Applications</i>, vol. 8, no. 1, 28, Springer Nature, 2019,
    doi:<a href="https://doi.org/10.1038/s41377-019-0124-3">10.1038/s41377-019-0124-3</a>.'
  short: 'B. Le Feber, J.E. Sipe, M. Wulf, L. Kuipers, N. Rotenberg, Light: Science
    and Applications 8 (2019).'
date_created: 2019-03-17T22:59:13Z
date_published: 2019-03-06T00:00:00Z
date_updated: 2023-08-25T08:06:10Z
day: '06'
ddc:
- '530'
department:
- _id: JoFi
doi: 10.1038/s41377-019-0124-3
external_id:
  arxiv:
  - '1803.10145'
  isi:
  - '000460470700004'
file:
- access_level: open_access
  checksum: d71e528cff9c56f70ccc29dd7005257f
  content_type: application/pdf
  creator: dernst
  date_created: 2019-03-18T08:08:22Z
  date_updated: 2020-07-14T12:47:19Z
  file_id: '6108'
  file_name: 2019_Light_LeFeber.pdf
  file_size: 1119947
  relation: main_file
file_date_updated: 2020-07-14T12:47:19Z
has_accepted_license: '1'
intvolume: '         8'
isi: 1
issue: '1'
language:
- iso: eng
month: '03'
oa: 1
oa_version: Published Version
publication: 'Light: Science and Applications'
publication_identifier:
  eissn:
  - '20477538'
  issn:
  - '20955545'
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
scopus_import: '1'
status: public
title: A full vectorial mapping of nanophotonic light fields
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 8
year: '2019'
...
---
_id: '6104'
abstract:
- lang: eng
  text: Abiotic stress poses constant challenges for plant survival and is a serious
    problem for global agricultural productivity. On a molecular level, stress conditions
    result in elevation of reactive oxygen species (ROS) production causing oxidative
    stress associated with oxidation of proteins and nucleic acids as well as impairment
    of membrane functions. Adaptation of root growth to ROS accumulation is facilitated
    through modification of auxin and cytokinin hormone homeostasis. Here, we report
    that in Arabidopsis root meristem, ROS-induced changes of auxin levels correspond
    to decreased abundance of PIN auxin efflux carriers at the plasma membrane (PM).
    Specifically, increase in H2O2 levels affects PIN2 endocytic recycling. We show
    that the PIN2 intracellular trafficking during adaptation to oxidative stress
    requires the function of the ADP-ribosylation factor (ARF)-guanine-nucleotide
    exchange factor (GEF) BEN1, an actin-associated regulator of the trafficking from
    the PM to early endosomes and, presumably, indirectly, trafficking to the vacuoles.
    We propose that H2O2 levels affect the actin dynamics thus modulating ARF-GEF-dependent
    trafficking of PIN2. This mechanism provides a way how root growth acclimates
    to stress and adapts to a changing environment.
article_processing_charge: No
author:
- first_name: Marta
  full_name: Zwiewka, Marta
  last_name: Zwiewka
- first_name: Agnieszka
  full_name: Bielach, Agnieszka
  last_name: Bielach
- first_name: Prashanth
  full_name: Tamizhselvan, Prashanth
  last_name: Tamizhselvan
- first_name: Sharmila
  full_name: Madhavan, Sharmila
  last_name: Madhavan
- first_name: Eman Elrefaay
  full_name: Ryad, Eman Elrefaay
  last_name: Ryad
- first_name: Shutang
  full_name: Tan, Shutang
  id: 2DE75584-F248-11E8-B48F-1D18A9856A87
  last_name: Tan
  orcid: 0000-0002-0471-8285
- first_name: Mónika
  full_name: Hrtyan, Mónika
  id: 45A71A74-F248-11E8-B48F-1D18A9856A87
  last_name: Hrtyan
- first_name: Petre
  full_name: Dobrev, Petre
  last_name: Dobrev
- first_name: Radomira
  full_name: Vanková, Radomira
  last_name: Vanková
- first_name: Jiří
  full_name: Friml, Jiří
  id: 4159519E-F248-11E8-B48F-1D18A9856A87
  last_name: Friml
  orcid: 0000-0002-8302-7596
- first_name: Vanesa B.
  full_name: Tognetti, Vanesa B.
  last_name: Tognetti
citation:
  ama: Zwiewka M, Bielach A, Tamizhselvan P, et al. Root adaptation to H2O2-induced
    oxidative stress by ARF-GEF BEN1- and cytoskeleton-mediated PIN2 trafficking.
    <i>Plant and Cell Physiology</i>. 2019;60(2):255-273. doi:<a href="https://doi.org/10.1093/pcp/pcz001">10.1093/pcp/pcz001</a>
  apa: Zwiewka, M., Bielach, A., Tamizhselvan, P., Madhavan, S., Ryad, E. E., Tan,
    S., … Tognetti, V. B. (2019). Root adaptation to H2O2-induced oxidative stress
    by ARF-GEF BEN1- and cytoskeleton-mediated PIN2 trafficking. <i>Plant and Cell
    Physiology</i>. Oxford University Press. <a href="https://doi.org/10.1093/pcp/pcz001">https://doi.org/10.1093/pcp/pcz001</a>
  chicago: Zwiewka, Marta, Agnieszka Bielach, Prashanth Tamizhselvan, Sharmila Madhavan,
    Eman Elrefaay Ryad, Shutang Tan, Mónika Hrtyan, et al. “Root Adaptation to H2O2-Induced
    Oxidative Stress by ARF-GEF BEN1- and Cytoskeleton-Mediated PIN2 Trafficking.”
    <i>Plant and Cell Physiology</i>. Oxford University Press, 2019. <a href="https://doi.org/10.1093/pcp/pcz001">https://doi.org/10.1093/pcp/pcz001</a>.
  ieee: M. Zwiewka <i>et al.</i>, “Root adaptation to H2O2-induced oxidative stress
    by ARF-GEF BEN1- and cytoskeleton-mediated PIN2 trafficking,” <i>Plant and Cell
    Physiology</i>, vol. 60, no. 2. Oxford University Press, pp. 255–273, 2019.
  ista: Zwiewka M, Bielach A, Tamizhselvan P, Madhavan S, Ryad EE, Tan S, Hrtyan M,
    Dobrev P, Vanková R, Friml J, Tognetti VB. 2019. Root adaptation to H2O2-induced
    oxidative stress by ARF-GEF BEN1- and cytoskeleton-mediated PIN2 trafficking.
    Plant and Cell Physiology. 60(2), 255–273.
  mla: Zwiewka, Marta, et al. “Root Adaptation to H2O2-Induced Oxidative Stress by
    ARF-GEF BEN1- and Cytoskeleton-Mediated PIN2 Trafficking.” <i>Plant and Cell Physiology</i>,
    vol. 60, no. 2, Oxford University Press, 2019, pp. 255–73, doi:<a href="https://doi.org/10.1093/pcp/pcz001">10.1093/pcp/pcz001</a>.
  short: M. Zwiewka, A. Bielach, P. Tamizhselvan, S. Madhavan, E.E. Ryad, S. Tan,
    M. Hrtyan, P. Dobrev, R. Vanková, J. Friml, V.B. Tognetti, Plant and Cell Physiology
    60 (2019) 255–273.
date_created: 2019-03-17T22:59:14Z
date_published: 2019-02-01T00:00:00Z
date_updated: 2023-08-25T08:05:28Z
day: '01'
department:
- _id: JiFr
doi: 10.1093/pcp/pcz001
external_id:
  isi:
  - '000459634300002'
  pmid:
  - '30668780'
intvolume: '        60'
isi: 1
issue: '2'
language:
- iso: eng
month: '02'
oa_version: None
page: 255-273
pmid: 1
publication: Plant and Cell Physiology
publication_identifier:
  eissn:
  - 1471-9053
  issn:
  - 0032-0781
publication_status: published
publisher: Oxford University Press
quality_controlled: '1'
scopus_import: '1'
status: public
title: Root adaptation to H2O2-induced oxidative stress by ARF-GEF BEN1- and cytoskeleton-mediated
  PIN2 trafficking
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 60
year: '2019'
...
---
_id: '6105'
abstract:
- lang: eng
  text: "    Hosts can alter their strategy towards pathogens during their lifetime;
    that is, they can show phenotypic plasticity in immunity or life history. Immune
    priming is one such example, where a previous encounter with a pathogen confers
    enhanced protection upon secondary challenge, resulting in reduced pathogen load
    (i.e., resistance) and improved host survival. However, an initial encounter might
    also enhance tolerance, particularly to less virulent opportunistic pathogens
    that establish persistent infections. In this scenario, individuals are better
    able to reduce the negative fecundity consequences that result from a high pathogen
    burden. Finally, previous exposure may also lead to life‐history adjustments,
    such as terminal investment into reproduction.\r\n    Using different Drosophila
    melanogaster host genotypes and two bacterial pathogens, Lactococcus lactis and
    Pseudomonas entomophila, we tested whether previous exposure results in resistance
    or tolerance and whether it modifies immune gene expression during an acute‐phase
    infection (one day post‐challenge). We then asked whether previous pathogen exposure
    affects chronic‐phase pathogen persistence and longer‐term survival (28 days post‐challenge).\r\n
    \   We predicted that previous exposure would increase host resistance to an early
    stage bacterial infection while it might come at a cost to host fecundity tolerance.
    We reasoned that resistance would be due in part to stronger immune gene expression
    after challenge. We expected that previous exposure would improve long‐term survival,
    that it would reduce infection persistence, and we expected to find genetic variation
    in these responses.\r\n    We found that previous exposure to P. entomophila weakened
    host resistance to a second infection independent of genotype and had no effect
    on immune gene expression. Fecundity tolerance showed genotypic variation but
    was not influenced by previous exposure. However, L. lactis persisted as a chronic
    infection, whereas survivors cleared the more pathogenic P. entomophila infection.\r\n
    \   To our knowledge, this is the first study that addresses host tolerance to
    bacteria in relation to previous exposure, taking a multi‐faceted approach to
    address the topic. Our results suggest that previous exposure comes with transient
    costs to resistance during the early stage of infection in this host–pathogen
    system and that infection persistence may be bacterium‐specific.\r\n"
article_processing_charge: No
article_type: original
author:
- first_name: Megan
  full_name: Kutzer, Megan
  id: 29D0B332-F248-11E8-B48F-1D18A9856A87
  last_name: Kutzer
  orcid: 0000-0002-8696-6978
- first_name: Joachim
  full_name: Kurtz, Joachim
  last_name: Kurtz
- first_name: Sophie A.O.
  full_name: Armitage, Sophie A.O.
  last_name: Armitage
citation:
  ama: Kutzer M, Kurtz J, Armitage SAO. A multi-faceted approach testing the effects
    of previous bacterial exposure on resistance and tolerance. <i>Journal of Animal
    Ecology</i>. 2019;88(4):566-578. doi:<a href="https://doi.org/10.1111/1365-2656.12953">10.1111/1365-2656.12953</a>
  apa: Kutzer, M., Kurtz, J., &#38; Armitage, S. A. O. (2019). A multi-faceted approach
    testing the effects of previous bacterial exposure on resistance and tolerance.
    <i>Journal of Animal Ecology</i>. Wiley. <a href="https://doi.org/10.1111/1365-2656.12953">https://doi.org/10.1111/1365-2656.12953</a>
  chicago: Kutzer, Megan, Joachim Kurtz, and Sophie A.O. Armitage. “A Multi-Faceted
    Approach Testing the Effects of Previous Bacterial Exposure on Resistance and
    Tolerance.” <i>Journal of Animal Ecology</i>. Wiley, 2019. <a href="https://doi.org/10.1111/1365-2656.12953">https://doi.org/10.1111/1365-2656.12953</a>.
  ieee: M. Kutzer, J. Kurtz, and S. A. O. Armitage, “A multi-faceted approach testing
    the effects of previous bacterial exposure on resistance and tolerance,” <i>Journal
    of Animal Ecology</i>, vol. 88, no. 4. Wiley, pp. 566–578, 2019.
  ista: Kutzer M, Kurtz J, Armitage SAO. 2019. A multi-faceted approach testing the
    effects of previous bacterial exposure on resistance and tolerance. Journal of
    Animal Ecology. 88(4), 566–578.
  mla: Kutzer, Megan, et al. “A Multi-Faceted Approach Testing the Effects of Previous
    Bacterial Exposure on Resistance and Tolerance.” <i>Journal of Animal Ecology</i>,
    vol. 88, no. 4, Wiley, 2019, pp. 566–78, doi:<a href="https://doi.org/10.1111/1365-2656.12953">10.1111/1365-2656.12953</a>.
  short: M. Kutzer, J. Kurtz, S.A.O. Armitage, Journal of Animal Ecology 88 (2019)
    566–578.
date_created: 2019-03-17T22:59:15Z
date_published: 2019-04-01T00:00:00Z
date_updated: 2023-08-25T08:04:53Z
day: '01'
ddc:
- '570'
department:
- _id: SyCr
doi: 10.1111/1365-2656.12953
ec_funded: 1
external_id:
  isi:
  - '000467994800007'
file:
- access_level: open_access
  checksum: 405cde15120de26018b3bd0dfa29986c
  content_type: application/pdf
  creator: dernst
  date_created: 2019-03-18T07:43:06Z
  date_updated: 2020-07-14T12:47:19Z
  file_id: '6107'
  file_name: 2019_JournalAnimalEcology_Kutzer.pdf
  file_size: 1460662
  relation: main_file
file_date_updated: 2020-07-14T12:47:19Z
has_accepted_license: '1'
intvolume: '        88'
isi: 1
issue: '4'
language:
- iso: eng
month: '04'
oa: 1
oa_version: Published Version
page: 566-578
project:
- _id: 25681D80-B435-11E9-9278-68D0E5697425
  call_identifier: FP7
  grant_number: '291734'
  name: International IST Postdoc Fellowship Programme
publication: Journal of Animal Ecology
publication_identifier:
  eissn:
  - '13652656'
  issn:
  - '00218790'
publication_status: published
publisher: Wiley
quality_controlled: '1'
related_material:
  record:
  - id: '9806'
    relation: research_data
    status: public
scopus_import: '1'
status: public
title: A multi-faceted approach testing the effects of previous bacterial exposure
  on resistance and tolerance
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 88
year: '2019'
...
---
_id: '6174'
abstract:
- lang: eng
  text: We propose a scaling theory for the many-body localization (MBL) phase transition
    in one dimension, building on the idea that it proceeds via a “quantum avalanche.”
    We argue that the critical properties can be captured at a coarse-grained level
    by a Kosterlitz-Thouless (KT) renormalization group (RG) flow. On phenomenological
    grounds, we identify the scaling variables as the density of thermal regions and
    the length scale that controls the decay of typical matrix elements. Within this
    KT picture, the MBL phase is a line of fixed points that terminates at the delocalization
    transition. We discuss two possible scenarios distinguished by the distribution
    of rare, fractal thermal inclusions within the MBL phase. In the first scenario,
    these regions have a stretched exponential distribution in the MBL phase. In the
    second scenario, the near-critical MBL phase hosts rare thermal regions that are
    power-law-distributed in size. This points to the existence of a second transition
    within the MBL phase, at which these power laws change to the stretched exponential
    form expected at strong disorder. We numerically simulate two different phenomenological
    RGs previously proposed to describe the MBL transition. Both RGs display a universal
    power-law length distribution of thermal regions at the transition with a critical
    exponent αc=2, and continuously varying exponents in the MBL phase consistent
    with the KT picture.
article_number: '094205'
article_processing_charge: No
article_type: original
arxiv: 1
author:
- first_name: Philipp T.
  full_name: Dumitrescu, Philipp T.
  last_name: Dumitrescu
- first_name: Anna
  full_name: Goremykina, Anna
  last_name: Goremykina
- first_name: Siddharth A.
  full_name: Parameswaran, Siddharth A.
  last_name: Parameswaran
- first_name: Maksym
  full_name: Serbyn, Maksym
  id: 47809E7E-F248-11E8-B48F-1D18A9856A87
  last_name: Serbyn
  orcid: 0000-0002-2399-5827
- first_name: Romain
  full_name: Vasseur, Romain
  last_name: Vasseur
citation:
  ama: Dumitrescu PT, Goremykina A, Parameswaran SA, Serbyn M, Vasseur R. Kosterlitz-Thouless
    scaling at many-body localization phase transitions. <i>Physical Review B</i>.
    2019;99(9). doi:<a href="https://doi.org/10.1103/physrevb.99.094205">10.1103/physrevb.99.094205</a>
  apa: Dumitrescu, P. T., Goremykina, A., Parameswaran, S. A., Serbyn, M., &#38; Vasseur,
    R. (2019). Kosterlitz-Thouless scaling at many-body localization phase transitions.
    <i>Physical Review B</i>. American Physical Society. <a href="https://doi.org/10.1103/physrevb.99.094205">https://doi.org/10.1103/physrevb.99.094205</a>
  chicago: Dumitrescu, Philipp T., Anna Goremykina, Siddharth A. Parameswaran, Maksym
    Serbyn, and Romain Vasseur. “Kosterlitz-Thouless Scaling at Many-Body Localization
    Phase Transitions.” <i>Physical Review B</i>. American Physical Society, 2019.
    <a href="https://doi.org/10.1103/physrevb.99.094205">https://doi.org/10.1103/physrevb.99.094205</a>.
  ieee: P. T. Dumitrescu, A. Goremykina, S. A. Parameswaran, M. Serbyn, and R. Vasseur,
    “Kosterlitz-Thouless scaling at many-body localization phase transitions,” <i>Physical
    Review B</i>, vol. 99, no. 9. American Physical Society, 2019.
  ista: Dumitrescu PT, Goremykina A, Parameswaran SA, Serbyn M, Vasseur R. 2019. Kosterlitz-Thouless
    scaling at many-body localization phase transitions. Physical Review B. 99(9),
    094205.
  mla: Dumitrescu, Philipp T., et al. “Kosterlitz-Thouless Scaling at Many-Body Localization
    Phase Transitions.” <i>Physical Review B</i>, vol. 99, no. 9, 094205, American
    Physical Society, 2019, doi:<a href="https://doi.org/10.1103/physrevb.99.094205">10.1103/physrevb.99.094205</a>.
  short: P.T. Dumitrescu, A. Goremykina, S.A. Parameswaran, M. Serbyn, R. Vasseur,
    Physical Review B 99 (2019).
date_created: 2019-03-25T07:32:08Z
date_published: 2019-03-22T00:00:00Z
date_updated: 2023-09-05T12:11:13Z
day: '22'
department:
- _id: MaSe
doi: 10.1103/physrevb.99.094205
external_id:
  arxiv:
  - '1811.03103'
  isi:
  - '000462883200001'
intvolume: '        99'
isi: 1
issue: '9'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://arxiv.org/abs/1811.03103
month: '03'
oa: 1
oa_version: Preprint
publication: Physical Review B
publication_identifier:
  eissn:
  - 2469-9969
  issn:
  - 2469-9950
publication_status: published
publisher: American Physical Society
quality_controlled: '1'
scopus_import: '1'
status: public
title: Kosterlitz-Thouless scaling at many-body localization phase transitions
type: journal_article
user_id: c635000d-4b10-11ee-a964-aac5a93f6ac1
volume: 99
year: '2019'
...
---
_id: '6175'
abstract:
- lang: eng
  text: "We consider the problem of expected cost analysis over nondeterministic probabilistic
    programs,\r\nwhich aims at automated methods for analyzing the resource-usage
    of such programs.\r\nPrevious approaches for this problem could only handle nonnegative
    bounded costs.\r\nHowever, in many scenarios, such as queuing networks or analysis
    of cryptocurrency protocols,\r\nboth positive and negative costs are necessary
    and the costs are unbounded as well.\r\n\r\nIn this work, we present a sound and
    efficient approach to obtain polynomial bounds on the\r\nexpected accumulated
    cost of nondeterministic probabilistic programs.\r\nOur approach can handle (a)
    general positive and negative costs with bounded updates in\r\nvariables; and
    (b) nonnegative costs with general updates to variables.\r\nWe show that several
    natural examples which could not be\r\nhandled by previous approaches are captured
    in our framework.\r\n\r\nMoreover, our approach leads to an efficient polynomial-time
    algorithm, while no\r\nprevious approach for cost analysis of probabilistic programs
    could guarantee polynomial runtime.\r\nFinally, we show the effectiveness of our
    approach using experimental results on a variety of programs for which we efficiently
    synthesize tight resource-usage bounds."
article_processing_charge: No
arxiv: 1
author:
- first_name: Peixin
  full_name: Wang, Peixin
  last_name: Wang
- first_name: Hongfei
  full_name: Fu, Hongfei
  id: 3AAD03D6-F248-11E8-B48F-1D18A9856A87
  last_name: Fu
- first_name: Amir Kafshdar
  full_name: Goharshady, Amir Kafshdar
  id: 391365CE-F248-11E8-B48F-1D18A9856A87
  last_name: Goharshady
  orcid: 0000-0003-1702-6584
- first_name: Krishnendu
  full_name: Chatterjee, Krishnendu
  id: 2E5DCA20-F248-11E8-B48F-1D18A9856A87
  last_name: Chatterjee
  orcid: 0000-0002-4561-241X
- first_name: Xudong
  full_name: Qin, Xudong
  last_name: Qin
- first_name: Wenjun
  full_name: Shi, Wenjun
  last_name: Shi
citation:
  ama: 'Wang P, Fu H, Goharshady AK, Chatterjee K, Qin X, Shi W. Cost analysis of
    nondeterministic probabilistic programs. In: <i>PLDI 2019: Proceedings of the
    40th ACM SIGPLAN Conference on Programming Language Design and Implementation</i>.
    Association for Computing Machinery; 2019:204-220. doi:<a href="https://doi.org/10.1145/3314221.3314581">10.1145/3314221.3314581</a>'
  apa: 'Wang, P., Fu, H., Goharshady, A. K., Chatterjee, K., Qin, X., &#38; Shi, W.
    (2019). Cost analysis of nondeterministic probabilistic programs. In <i>PLDI 2019:
    Proceedings of the 40th ACM SIGPLAN Conference on Programming Language Design
    and Implementation</i> (pp. 204–220). Phoenix, AZ, United States: Association
    for Computing Machinery. <a href="https://doi.org/10.1145/3314221.3314581">https://doi.org/10.1145/3314221.3314581</a>'
  chicago: 'Wang, Peixin, Hongfei Fu, Amir Kafshdar Goharshady, Krishnendu Chatterjee,
    Xudong Qin, and Wenjun Shi. “Cost Analysis of Nondeterministic Probabilistic Programs.”
    In <i>PLDI 2019: Proceedings of the 40th ACM SIGPLAN Conference on Programming
    Language Design and Implementation</i>, 204–20. Association for Computing Machinery,
    2019. <a href="https://doi.org/10.1145/3314221.3314581">https://doi.org/10.1145/3314221.3314581</a>.'
  ieee: 'P. Wang, H. Fu, A. K. Goharshady, K. Chatterjee, X. Qin, and W. Shi, “Cost
    analysis of nondeterministic probabilistic programs,” in <i>PLDI 2019: Proceedings
    of the 40th ACM SIGPLAN Conference on Programming Language Design and Implementation</i>,
    Phoenix, AZ, United States, 2019, pp. 204–220.'
  ista: 'Wang P, Fu H, Goharshady AK, Chatterjee K, Qin X, Shi W. 2019. Cost analysis
    of nondeterministic probabilistic programs. PLDI 2019: Proceedings of the 40th
    ACM SIGPLAN Conference on Programming Language Design and Implementation. PLDI:
    Conference on Programming Language Design and Implementation, 204–220.'
  mla: 'Wang, Peixin, et al. “Cost Analysis of Nondeterministic Probabilistic Programs.”
    <i>PLDI 2019: Proceedings of the 40th ACM SIGPLAN Conference on Programming Language
    Design and Implementation</i>, Association for Computing Machinery, 2019, pp.
    204–20, doi:<a href="https://doi.org/10.1145/3314221.3314581">10.1145/3314221.3314581</a>.'
  short: 'P. Wang, H. Fu, A.K. Goharshady, K. Chatterjee, X. Qin, W. Shi, in:, PLDI
    2019: Proceedings of the 40th ACM SIGPLAN Conference on Programming Language Design
    and Implementation, Association for Computing Machinery, 2019, pp. 204–220.'
conference:
  end_date: 2019-06-26
  location: Phoenix, AZ, United States
  name: 'PLDI: Conference on Programming Language Design and Implementation'
  start_date: 2019-06-22
date_created: 2019-03-25T10:13:25Z
date_published: 2019-06-08T00:00:00Z
date_updated: 2025-06-02T08:53:45Z
day: '08'
ddc:
- '000'
department:
- _id: KrCh
doi: 10.1145/3314221.3314581
ec_funded: 1
external_id:
  arxiv:
  - '1902.04659'
  isi:
  - '000523190300014'
file:
- access_level: open_access
  checksum: 703a5e9b8c8587f2a44085ffd9a4db64
  content_type: application/pdf
  creator: akafshda
  date_created: 2019-03-25T10:11:22Z
  date_updated: 2020-07-14T12:47:20Z
  file_id: '6176'
  file_name: paper.pdf
  file_size: 4051066
  relation: main_file
file_date_updated: 2020-07-14T12:47:20Z
has_accepted_license: '1'
isi: 1
keyword:
- Program Cost Analysis
- Program Termination
- Probabilistic Programs
- Martingales
language:
- iso: eng
month: '06'
oa: 1
oa_version: Submitted Version
page: 204-220
project:
- _id: 25892FC0-B435-11E9-9278-68D0E5697425
  grant_number: ICT15-003
  name: Efficient Algorithms for Computer Aided Verification
- _id: 25863FF4-B435-11E9-9278-68D0E5697425
  call_identifier: FWF
  grant_number: S11407
  name: Game Theory
- _id: 25832EC2-B435-11E9-9278-68D0E5697425
  call_identifier: FWF
  grant_number: S 11407_N23
  name: Rigorous Systems Engineering
- _id: 2581B60A-B435-11E9-9278-68D0E5697425
  call_identifier: FP7
  grant_number: '279307'
  name: 'Quantitative Graph Games: Theory and Applications'
- _id: 266EEEC0-B435-11E9-9278-68D0E5697425
  name: Quantitative Game-theoretic Analysis of Blockchain Applications and Smart
    Contracts
publication: 'PLDI 2019: Proceedings of the 40th ACM SIGPLAN Conference on Programming
  Language Design and Implementation'
publication_status: published
publisher: Association for Computing Machinery
quality_controlled: '1'
related_material:
  record:
  - id: '5457'
    relation: earlier_version
    status: public
  - id: '8934'
    relation: dissertation_contains
    status: public
scopus_import: '1'
status: public
title: Cost analysis of nondeterministic probabilistic programs
type: conference
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
year: '2019'
...
---
_id: '6179'
abstract:
- lang: eng
  text: "In the first part of this thesis we consider large random matrices with arbitrary
    expectation and a general slowly decaying correlation among its entries. We prove
    universality of the local eigenvalue statistics and optimal local laws for the
    resolvent in the bulk and edge regime. The main novel tool is a systematic diagrammatic
    control of a multivariate cumulant expansion.\r\nIn the second part we consider
    Wigner-type matrices and show that at any cusp singularity of the limiting eigenvalue
    distribution the local eigenvalue statistics are uni- versal and form a Pearcey
    process. Since the density of states typically exhibits only square root or cubic
    root cusp singularities, our work complements previous results on the bulk and
    edge universality and it thus completes the resolution of the Wigner- Dyson-Mehta
    universality conjecture for the last remaining universality type. Our analysis
    holds not only for exact cusps, but approximate cusps as well, where an ex- tended
    Pearcey process emerges. As a main technical ingredient we prove an optimal local
    law at the cusp, and extend the fast relaxation to equilibrium of the Dyson Brow-
    nian motion to the cusp regime.\r\nIn the third and final part we explore the
    entrywise linear statistics of Wigner ma- trices and identify the fluctuations
    for a large class of test functions with little regularity. This enables us to
    study the rectangular Young diagram obtained from the interlacing eigenvalues
    of the random matrix and its minor, and we find that, despite having the same
    limit, the fluctuations differ from those of the algebraic Young tableaux equipped
    with the Plancharel measure."
alternative_title:
- ISTA Thesis
article_processing_charge: No
author:
- first_name: Dominik J
  full_name: Schröder, Dominik J
  id: 408ED176-F248-11E8-B48F-1D18A9856A87
  last_name: Schröder
  orcid: 0000-0002-2904-1856
citation:
  ama: 'Schröder DJ. From Dyson to Pearcey: Universal statistics in random matrix
    theory. 2019. doi:<a href="https://doi.org/10.15479/AT:ISTA:th6179">10.15479/AT:ISTA:th6179</a>'
  apa: 'Schröder, D. J. (2019). <i>From Dyson to Pearcey: Universal statistics in
    random matrix theory</i>. Institute of Science and Technology Austria. <a href="https://doi.org/10.15479/AT:ISTA:th6179">https://doi.org/10.15479/AT:ISTA:th6179</a>'
  chicago: 'Schröder, Dominik J. “From Dyson to Pearcey: Universal Statistics in Random
    Matrix Theory.” Institute of Science and Technology Austria, 2019. <a href="https://doi.org/10.15479/AT:ISTA:th6179">https://doi.org/10.15479/AT:ISTA:th6179</a>.'
  ieee: 'D. J. Schröder, “From Dyson to Pearcey: Universal statistics in random matrix
    theory,” Institute of Science and Technology Austria, 2019.'
  ista: 'Schröder DJ. 2019. From Dyson to Pearcey: Universal statistics in random
    matrix theory. Institute of Science and Technology Austria.'
  mla: 'Schröder, Dominik J. <i>From Dyson to Pearcey: Universal Statistics in Random
    Matrix Theory</i>. Institute of Science and Technology Austria, 2019, doi:<a href="https://doi.org/10.15479/AT:ISTA:th6179">10.15479/AT:ISTA:th6179</a>.'
  short: 'D.J. Schröder, From Dyson to Pearcey: Universal Statistics in Random Matrix
    Theory, Institute of Science and Technology Austria, 2019.'
date_created: 2019-03-28T08:58:59Z
date_published: 2019-03-18T00:00:00Z
date_updated: 2024-02-22T14:34:33Z
day: '18'
ddc:
- '515'
- '519'
degree_awarded: PhD
department:
- _id: LaEr
doi: 10.15479/AT:ISTA:th6179
ec_funded: 1
file:
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project:
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  call_identifier: FP7
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  name: Random matrices, universality and disordered quantum systems
publication_identifier:
  issn:
  - 2663-337X
publication_status: published
publisher: Institute of Science and Technology Austria
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supervisor:
- first_name: László
  full_name: Erdös, László
  id: 4DBD5372-F248-11E8-B48F-1D18A9856A87
  last_name: Erdös
  orcid: 0000-0001-5366-9603
title: 'From Dyson to Pearcey: Universal statistics in random matrix theory'
type: dissertation
user_id: c635000d-4b10-11ee-a964-aac5a93f6ac1
year: '2019'
...
---
_id: '6182'
abstract:
- lang: eng
  text: "We consider large random matrices with a general slowly decaying correlation
    among its entries. We prove universality of the local eigenvalue statistics and
    optimal local laws for the resolvent away from the spectral edges, generalizing
    the recent result of Ajanki et al. [‘Stability of the matrix Dyson equation and
    random matrices with correlations’, Probab. Theory Related Fields 173(1–2) (2019),
    293–373] to allow slow correlation decay and arbitrary expectation. The main novel
    tool is\r\na systematic diagrammatic control of a multivariate cumulant expansion."
article_number: e8
article_processing_charge: No
article_type: original
arxiv: 1
author:
- first_name: László
  full_name: Erdös, László
  id: 4DBD5372-F248-11E8-B48F-1D18A9856A87
  last_name: Erdös
  orcid: 0000-0001-5366-9603
- first_name: Torben H
  full_name: Krüger, Torben H
  id: 3020C786-F248-11E8-B48F-1D18A9856A87
  last_name: Krüger
  orcid: 0000-0002-4821-3297
- first_name: Dominik J
  full_name: Schröder, Dominik J
  id: 408ED176-F248-11E8-B48F-1D18A9856A87
  last_name: Schröder
  orcid: 0000-0002-2904-1856
citation:
  ama: Erdös L, Krüger TH, Schröder DJ. Random matrices with slow correlation decay.
    <i>Forum of Mathematics, Sigma</i>. 2019;7. doi:<a href="https://doi.org/10.1017/fms.2019.2">10.1017/fms.2019.2</a>
  apa: Erdös, L., Krüger, T. H., &#38; Schröder, D. J. (2019). Random matrices with
    slow correlation decay. <i>Forum of Mathematics, Sigma</i>. Cambridge University
    Press. <a href="https://doi.org/10.1017/fms.2019.2">https://doi.org/10.1017/fms.2019.2</a>
  chicago: Erdös, László, Torben H Krüger, and Dominik J Schröder. “Random Matrices
    with Slow Correlation Decay.” <i>Forum of Mathematics, Sigma</i>. Cambridge University
    Press, 2019. <a href="https://doi.org/10.1017/fms.2019.2">https://doi.org/10.1017/fms.2019.2</a>.
  ieee: L. Erdös, T. H. Krüger, and D. J. Schröder, “Random matrices with slow correlation
    decay,” <i>Forum of Mathematics, Sigma</i>, vol. 7. Cambridge University Press,
    2019.
  ista: Erdös L, Krüger TH, Schröder DJ. 2019. Random matrices with slow correlation
    decay. Forum of Mathematics, Sigma. 7, e8.
  mla: Erdös, László, et al. “Random Matrices with Slow Correlation Decay.” <i>Forum
    of Mathematics, Sigma</i>, vol. 7, e8, Cambridge University Press, 2019, doi:<a
    href="https://doi.org/10.1017/fms.2019.2">10.1017/fms.2019.2</a>.
  short: L. Erdös, T.H. Krüger, D.J. Schröder, Forum of Mathematics, Sigma 7 (2019).
date_created: 2019-03-28T09:05:23Z
date_published: 2019-03-26T00:00:00Z
date_updated: 2023-09-07T12:54:12Z
day: '26'
ddc:
- '510'
department:
- _id: LaEr
doi: 10.1017/fms.2019.2
ec_funded: 1
external_id:
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file_date_updated: 2020-07-14T12:47:22Z
has_accepted_license: '1'
intvolume: '         7'
isi: 1
language:
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month: '03'
oa: 1
oa_version: Published Version
project:
- _id: 258DCDE6-B435-11E9-9278-68D0E5697425
  call_identifier: FP7
  grant_number: '338804'
  name: Random matrices, universality and disordered quantum systems
publication: Forum of Mathematics, Sigma
publication_identifier:
  eissn:
  - '20505094'
publication_status: published
publisher: Cambridge University Press
quality_controlled: '1'
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scopus_import: '1'
status: public
title: Random matrices with slow correlation decay
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type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
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...
