--- _id: '12298' abstract: - lang: eng text: 'Existing committee-based Byzantine state machine replication (SMR) protocols, typically deployed in production blockchains, face a clear trade-off: (1) they either achieve linear communication cost in the steady state, but sacrifice liveness during periods of asynchrony, or (2) they are robust (progress with probability one) but pay quadratic communication cost. We believe this trade-off is unwarranted since existing linear protocols still have asymptotic quadratic cost in the worst case. We design Ditto, a Byzantine SMR protocol that enjoys the best of both worlds: optimal communication on and off the steady state (linear and quadratic, respectively) and progress guarantee under asynchrony and DDoS attacks. We achieve this by replacing the view-synchronization of partially synchronous protocols with an asynchronous fallback mechanism at no extra asymptotic cost. Specifically, we start from HotStuff, a state-of-the-art linear protocol, and gradually build Ditto. As a separate contribution and an intermediate step, we design a 2-chain version of HotStuff, Jolteon, which leverages a quadratic view-change mechanism to reduce the latency of the standard 3-chain HotStuff. We implement and experimentally evaluate all our systems to prove that breaking the robustness-efficiency trade-off is in the realm of practicality.' acknowledgement: We thank our shepherd Aniket Kate and the anonymous reviewers at FC 2022 for their helpful feedback. This work is supported by the Novi team at Facebook. We also thank the Novi Research and Engineering teams for valuable feedback, and in particular Mathieu Baudet, Andrey Chursin, George Danezis, Zekun Li, and Dahlia Malkhi for discussions that shaped this work. alternative_title: - LNCS article_processing_charge: No arxiv: 1 author: - first_name: Rati full_name: Gelashvili, Rati last_name: Gelashvili - first_name: Eleftherios full_name: Kokoris Kogias, Eleftherios id: f5983044-d7ef-11ea-ac6d-fd1430a26d30 last_name: Kokoris Kogias - first_name: Alberto full_name: Sonnino, Alberto last_name: Sonnino - first_name: Alexander full_name: Spiegelman, Alexander last_name: Spiegelman - first_name: Zhuolun full_name: Xiang, Zhuolun last_name: Xiang citation: ama: 'Gelashvili R, Kokoris Kogias E, Sonnino A, Spiegelman A, Xiang Z. Jolteon and ditto: Network-adaptive efficient consensus with asynchronous fallback. In: Financial Cryptography and Data Security. Vol 13411. Springer Nature; 2022:296-315. doi:10.1007/978-3-031-18283-9_14' apa: 'Gelashvili, R., Kokoris Kogias, E., Sonnino, A., Spiegelman, A., & Xiang, Z. (2022). Jolteon and ditto: Network-adaptive efficient consensus with asynchronous fallback. In Financial Cryptography and Data Security (Vol. 13411, pp. 296–315). Radisson Grenada Beach Resort, Grenada: Springer Nature. https://doi.org/10.1007/978-3-031-18283-9_14' chicago: 'Gelashvili, Rati, Eleftherios Kokoris Kogias, Alberto Sonnino, Alexander Spiegelman, and Zhuolun Xiang. “Jolteon and Ditto: Network-Adaptive Efficient Consensus with Asynchronous Fallback.” In Financial Cryptography and Data Security, 13411:296–315. Springer Nature, 2022. https://doi.org/10.1007/978-3-031-18283-9_14.' ieee: 'R. Gelashvili, E. Kokoris Kogias, A. Sonnino, A. Spiegelman, and Z. Xiang, “Jolteon and ditto: Network-adaptive efficient consensus with asynchronous fallback,” in Financial Cryptography and Data Security, Radisson Grenada Beach Resort, Grenada, 2022, vol. 13411, pp. 296–315.' ista: 'Gelashvili R, Kokoris Kogias E, Sonnino A, Spiegelman A, Xiang Z. 2022. Jolteon and ditto: Network-adaptive efficient consensus with asynchronous fallback. Financial Cryptography and Data Security. FC: Financial Cryptography, LNCS, vol. 13411, 296–315.' mla: 'Gelashvili, Rati, et al. “Jolteon and Ditto: Network-Adaptive Efficient Consensus with Asynchronous Fallback.” Financial Cryptography and Data Security, vol. 13411, Springer Nature, 2022, pp. 296–315, doi:10.1007/978-3-031-18283-9_14.' short: R. Gelashvili, E. Kokoris Kogias, A. Sonnino, A. Spiegelman, Z. Xiang, in:, Financial Cryptography and Data Security, Springer Nature, 2022, pp. 296–315. conference: end_date: 2022-05-06 location: Radisson Grenada Beach Resort, Grenada name: 'FC: Financial Cryptography' start_date: 2022-05-02 date_created: 2023-01-16T10:05:51Z date_published: 2022-10-22T00:00:00Z date_updated: 2023-09-05T15:13:17Z day: '22' department: - _id: ElKo doi: 10.1007/978-3-031-18283-9_14 external_id: arxiv: - '2106.10362' intvolume: ' 13411' language: - iso: eng main_file_link: - open_access: '1' url: ' https://doi.org/10.48550/arXiv.2106.10362' month: '10' oa: 1 oa_version: Preprint page: 296-315 publication: Financial Cryptography and Data Security publication_identifier: eisbn: - '9783031182839' eissn: - 1611-3349 isbn: - '9783031182822' issn: - 0302-9743 publication_status: published publisher: Springer Nature quality_controlled: '1' scopus_import: '1' status: public title: 'Jolteon and ditto: Network-adaptive efficient consensus with asynchronous fallback' type: conference user_id: c635000d-4b10-11ee-a964-aac5a93f6ac1 volume: 13411 year: '2022' ... --- _id: '12299' abstract: - lang: eng text: 'Transfer learning is a classic paradigm by which models pretrained on large “upstream” datasets are adapted to yield good results on “downstream” specialized datasets. Generally, more accurate models on the “upstream” dataset tend to provide better transfer accuracy “downstream”. In this work, we perform an in-depth investigation of this phenomenon in the context of convolutional neural networks (CNNs) trained on the ImageNet dataset, which have been pruned-that is, compressed by sparsifiying their connections. We consider transfer using unstructured pruned models obtained by applying several state-of-the-art pruning methods, including magnitude-based, second-order, regrowth, lottery-ticket, and regularization approaches, in the context of twelve standard transfer tasks. In a nutshell, our study shows that sparse models can match or even outperform the transfer performance of dense models, even at high sparsities, and, while doing so, can lead to significant inference and even training speedups. At the same time, we observe and analyze significant differences in the behaviour of different pruning methods. The code is available at: https://github.com/IST-DASLab/sparse-imagenet-transfer.' acknowledgement: he authors would like to sincerely thank Christoph Lampert and Nir Shavit for fruitful discussions during the development of this work, and Eldar Kurtic for experimental support. EI was supported in part by the FWF DK VGSCO, grant agreement number W1260-N35, while AP and DA acknowledge generous support by the ERC, via Starting Grant 805223 ScaleML. article_processing_charge: No arxiv: 1 author: - first_name: Eugenia B full_name: Iofinova, Eugenia B id: f9a17499-f6e0-11ea-865d-fdf9a3f77117 last_name: Iofinova orcid: 0000-0002-7778-3221 - first_name: Elena-Alexandra full_name: Peste, Elena-Alexandra id: 32D78294-F248-11E8-B48F-1D18A9856A87 last_name: Peste - first_name: Mark full_name: Kurtz, Mark last_name: Kurtz - first_name: Dan-Adrian full_name: Alistarh, Dan-Adrian id: 4A899BFC-F248-11E8-B48F-1D18A9856A87 last_name: Alistarh orcid: 0000-0003-3650-940X citation: ama: 'Iofinova EB, Peste E-A, Kurtz M, Alistarh D-A. How well do sparse ImageNet models transfer? In: 2022 IEEE/CVF Conference on Computer Vision and Pattern Recognition. Institute of Electrical and Electronics Engineers; 2022:12256-12266. doi:10.1109/cvpr52688.2022.01195' apa: 'Iofinova, E. B., Peste, E.-A., Kurtz, M., & Alistarh, D.-A. (2022). How well do sparse ImageNet models transfer? In 2022 IEEE/CVF Conference on Computer Vision and Pattern Recognition (pp. 12256–12266). New Orleans, LA, United States: Institute of Electrical and Electronics Engineers. https://doi.org/10.1109/cvpr52688.2022.01195' chicago: Iofinova, Eugenia B, Elena-Alexandra Peste, Mark Kurtz, and Dan-Adrian Alistarh. “How Well Do Sparse ImageNet Models Transfer?” In 2022 IEEE/CVF Conference on Computer Vision and Pattern Recognition, 12256–66. Institute of Electrical and Electronics Engineers, 2022. https://doi.org/10.1109/cvpr52688.2022.01195. ieee: E. B. Iofinova, E.-A. Peste, M. Kurtz, and D.-A. Alistarh, “How well do sparse ImageNet models transfer?,” in 2022 IEEE/CVF Conference on Computer Vision and Pattern Recognition, New Orleans, LA, United States, 2022, pp. 12256–12266. ista: 'Iofinova EB, Peste E-A, Kurtz M, Alistarh D-A. 2022. How well do sparse ImageNet models transfer? 2022 IEEE/CVF Conference on Computer Vision and Pattern Recognition. CVPR: Computer Vision and Pattern Recognition, 12256–12266.' mla: Iofinova, Eugenia B., et al. “How Well Do Sparse ImageNet Models Transfer?” 2022 IEEE/CVF Conference on Computer Vision and Pattern Recognition, Institute of Electrical and Electronics Engineers, 2022, pp. 12256–66, doi:10.1109/cvpr52688.2022.01195. short: E.B. Iofinova, E.-A. Peste, M. Kurtz, D.-A. Alistarh, in:, 2022 IEEE/CVF Conference on Computer Vision and Pattern Recognition, Institute of Electrical and Electronics Engineers, 2022, pp. 12256–12266. conference: end_date: 2022-06-24 location: New Orleans, LA, United States name: 'CVPR: Computer Vision and Pattern Recognition' start_date: 2022-06-18 date_created: 2023-01-16T10:06:00Z date_published: 2022-09-27T00:00:00Z date_updated: 2023-08-04T10:33:28Z day: '27' department: - _id: DaAl - _id: ChLa doi: 10.1109/cvpr52688.2022.01195 ec_funded: 1 external_id: arxiv: - '2111.13445' isi: - '000870759105034' isi: 1 language: - iso: eng main_file_link: - open_access: '1' url: https://doi.org/10.48550/arXiv.2111.13445 month: '09' oa: 1 oa_version: Preprint page: 12256-12266 project: - _id: 9B9290DE-BA93-11EA-9121-9846C619BF3A grant_number: ' W1260-N35' name: Vienna Graduate School on Computational Optimization - _id: 268A44D6-B435-11E9-9278-68D0E5697425 call_identifier: H2020 grant_number: '805223' name: Elastic Coordination for Scalable Machine Learning publication: 2022 IEEE/CVF Conference on Computer Vision and Pattern Recognition publication_identifier: eissn: - 2575-7075 publication_status: published publisher: Institute of Electrical and Electronics Engineers quality_controlled: '1' related_material: record: - id: '13074' relation: dissertation_contains status: public scopus_import: '1' status: public title: How well do sparse ImageNet models transfer? type: conference user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8 year: '2022' ... --- _id: '12300' abstract: - lang: eng text: Distributed Key Generation (DKG) is a technique to bootstrap threshold cryptosystems without a trusted third party and is a building block to decentralized protocols such as randomness beacons, threshold signatures, and general multiparty computation. Until recently, DKG protocols have assumed the synchronous model and thus are vulnerable when their underlying network assumptions do not hold. The recent advancements in asynchronous DKG protocols are insufficient as they either have poor efficiency or limited functionality, resulting in a lack of concrete implementations. In this paper, we present a simple and concretely efficient asynchronous DKG (ADKG) protocol. In a network of n nodes, our ADKG protocol can tolerate up to t2022 IEEE Symposium on Security and Privacy. Institute of Electrical and Electronics Engineers; 2022:2518-2534. doi:10.1109/sp46214.2022.9833584' apa: 'Das, S., Yurek, T., Xiang, Z., Miller, A., Kokoris Kogias, E., & Ren, L. (2022). Practical asynchronous distributed key generation. In 2022 IEEE Symposium on Security and Privacy (pp. 2518–2534). San Francisco, CA, United States: Institute of Electrical and Electronics Engineers. https://doi.org/10.1109/sp46214.2022.9833584' chicago: Das, Sourav, Thomas Yurek, Zhuolun Xiang, Andrew Miller, Eleftherios Kokoris Kogias, and Ling Ren. “Practical Asynchronous Distributed Key Generation.” In 2022 IEEE Symposium on Security and Privacy, 2518–34. Institute of Electrical and Electronics Engineers, 2022. https://doi.org/10.1109/sp46214.2022.9833584. ieee: S. Das, T. Yurek, Z. Xiang, A. Miller, E. Kokoris Kogias, and L. Ren, “Practical asynchronous distributed key generation,” in 2022 IEEE Symposium on Security and Privacy, San Francisco, CA, United States, 2022, pp. 2518–2534. ista: 'Das S, Yurek T, Xiang Z, Miller A, Kokoris Kogias E, Ren L. 2022. Practical asynchronous distributed key generation. 2022 IEEE Symposium on Security and Privacy. SP: Symposium on Security and Privacy, 2518–2534.' mla: Das, Sourav, et al. “Practical Asynchronous Distributed Key Generation.” 2022 IEEE Symposium on Security and Privacy, Institute of Electrical and Electronics Engineers, 2022, pp. 2518–34, doi:10.1109/sp46214.2022.9833584. short: S. Das, T. Yurek, Z. Xiang, A. Miller, E. Kokoris Kogias, L. Ren, in:, 2022 IEEE Symposium on Security and Privacy, Institute of Electrical and Electronics Engineers, 2022, pp. 2518–2534. conference: end_date: 2022-05-26 location: San Francisco, CA, United States name: 'SP: Symposium on Security and Privacy' start_date: 2022-05-23 date_created: 2023-01-16T10:06:11Z date_published: 2022-07-27T00:00:00Z date_updated: 2023-02-16T07:43:53Z day: '27' department: - _id: ElKo doi: 10.1109/sp46214.2022.9833584 language: - iso: eng main_file_link: - open_access: '1' url: https://eprint.iacr.org/2021/1591 month: '07' oa: 1 oa_version: Preprint page: 2518-2534 publication: 2022 IEEE Symposium on Security and Privacy publication_identifier: eisbn: - '9781665413169' eissn: - 2375-1207 publication_status: published publisher: Institute of Electrical and Electronics Engineers quality_controlled: '1' scopus_import: '1' status: public title: Practical asynchronous distributed key generation type: conference user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87 year: '2022' ... --- _id: '12302' abstract: - lang: eng text: 'We propose a novel algorithm to decide the language inclusion between (nondeterministic) Büchi automata, a PSPACE-complete problem. Our approach, like others before, leverage a notion of quasiorder to prune the search for a counterexample by discarding candidates which are subsumed by others for the quasiorder. Discarded candidates are guaranteed to not compromise the completeness of the algorithm. The novelty of our work lies in the quasiorder used to discard candidates. We introduce FORQs (family of right quasiorders) that we obtain by adapting the notion of family of right congruences put forward by Maler and Staiger in 1993. We define a FORQ-based inclusion algorithm which we prove correct and instantiate it for a specific FORQ, called the structural FORQ, induced by the Büchi automaton to the right of the inclusion sign. The resulting implementation, called FORKLIFT, scales up better than the state-of-the-art on a variety of benchmarks including benchmarks from program verification and theorem proving for word combinatorics. Artifact: https://doi.org/10.5281/zenodo.6552870' acknowledgement: This work was partially funded by the ESF Investing in your future, the Madrid regional project S2018/TCS-4339 BLOQUES, the Spanish project PGC2018-102210-B-I00 BOSCO, the Ramón y Cajal fellowship RYC-2016-20281, and the ERC grant PR1001ERC02. alternative_title: - LNCS article_processing_charge: No arxiv: 1 author: - first_name: Kyveli full_name: Doveri, Kyveli last_name: Doveri - first_name: Pierre full_name: Ganty, Pierre last_name: Ganty - first_name: Nicolas Adrien full_name: Mazzocchi, Nicolas Adrien id: b26baa86-3308-11ec-87b0-8990f34baa85 last_name: Mazzocchi citation: ama: 'Doveri K, Ganty P, Mazzocchi NA. FORQ-based language inclusion formal testing. In: Computer Aided Verification. Vol 13372. Springer Nature; 2022:109-129. doi:10.1007/978-3-031-13188-2_6' apa: 'Doveri, K., Ganty, P., & Mazzocchi, N. A. (2022). FORQ-based language inclusion formal testing. In Computer Aided Verification (Vol. 13372, pp. 109–129). Haifa, Israel: Springer Nature. https://doi.org/10.1007/978-3-031-13188-2_6' chicago: Doveri, Kyveli, Pierre Ganty, and Nicolas Adrien Mazzocchi. “FORQ-Based Language Inclusion Formal Testing.” In Computer Aided Verification, 13372:109–29. Springer Nature, 2022. https://doi.org/10.1007/978-3-031-13188-2_6. ieee: K. Doveri, P. Ganty, and N. A. Mazzocchi, “FORQ-based language inclusion formal testing,” in Computer Aided Verification, Haifa, Israel, 2022, vol. 13372, pp. 109–129. ista: 'Doveri K, Ganty P, Mazzocchi NA. 2022. FORQ-based language inclusion formal testing. Computer Aided Verification. CAV: Computer Aided Verification, LNCS, vol. 13372, 109–129.' mla: Doveri, Kyveli, et al. “FORQ-Based Language Inclusion Formal Testing.” Computer Aided Verification, vol. 13372, Springer Nature, 2022, pp. 109–29, doi:10.1007/978-3-031-13188-2_6. short: K. Doveri, P. Ganty, N.A. Mazzocchi, in:, Computer Aided Verification, Springer Nature, 2022, pp. 109–129. conference: end_date: 2022-08-10 location: Haifa, Israel name: 'CAV: Computer Aided Verification' start_date: 2022-08-07 date_created: 2023-01-16T10:06:31Z date_published: 2022-08-06T00:00:00Z date_updated: 2023-09-05T15:13:36Z day: '06' ddc: - '000' department: - _id: ToHe doi: 10.1007/978-3-031-13188-2_6 ec_funded: 1 external_id: arxiv: - '2207.13549' isi: - '000870310500006' file: - access_level: open_access checksum: edc363b1be5447a09063e115c247918a content_type: application/pdf creator: dernst date_created: 2023-01-30T12:51:02Z date_updated: 2023-01-30T12:51:02Z file_id: '12465' file_name: 2022_LNCS_Doveri.pdf file_size: 497682 relation: main_file success: 1 file_date_updated: 2023-01-30T12:51:02Z has_accepted_license: '1' intvolume: ' 13372' isi: 1 language: - iso: eng month: '08' oa: 1 oa_version: Published Version page: 109-129 project: - _id: 62781420-2b32-11ec-9570-8d9b63373d4d call_identifier: H2020 grant_number: '101020093' name: Vigilant Algorithmic Monitoring of Software publication: Computer Aided Verification publication_identifier: eisbn: - '9783031131882' eissn: - 1611-3349 isbn: - '9783031131875' issn: - 0302-9743 publication_status: published publisher: Springer Nature quality_controlled: '1' scopus_import: '1' status: public title: FORQ-based language inclusion formal testing tmp: image: /images/cc_by.png legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0) short: CC BY (4.0) type: conference user_id: c635000d-4b10-11ee-a964-aac5a93f6ac1 volume: 13372 year: '2022' ... --- _id: '12303' abstract: - lang: eng text: We construct for each choice of a quiver Q, a cohomology theory A, and a poset P a “loop Grassmannian” GP(Q,A). This generalizes loop Grassmannians of semisimple groups and the loop Grassmannians of based quadratic forms. The addition of a “dilation” torus D⊆G2m gives a quantization GPD(Q,A). This construction is motivated by the program of introducing an inner cohomology theory in algebraic geometry adequate for the Geometric Langlands program (Mirković, Some extensions of the notion of loop Grassmannians. Rad Hrvat. Akad. Znan. Umjet. Mat. Znan., the Mardešić issue. No. 532, 53–74, 2017) and on the construction of affine quantum groups from generalized cohomology theories (Yang and Zhao, Quiver varieties and elliptic quantum groups, preprint. arxiv1708.01418). acknowledgement: I.M. thanks Zhijie Dong for long-term discussions on the material that entered this work. We thank Misha Finkelberg for pointing out errors in earlier versions. His advice and his insistence have led to a much better paper. A part of the writing was done at the conference at IST (Vienna) attended by all coauthors. We therefore thank the organizers of the conference and the support of ERC Advanced Grant Arithmetic and Physics of Higgs moduli spaces No. 320593. The work of I.M. was partially supported by NSF grants. The work of Y.Y. was partially supported by the Australian Research Council (ARC) via the award DE190101231. The work of G.Z. was partially supported by ARC via the award DE190101222. alternative_title: - Trends in Mathematics article_processing_charge: No arxiv: 1 author: - first_name: Ivan full_name: Mirković, Ivan last_name: Mirković - first_name: Yaping full_name: Yang, Yaping last_name: Yang - first_name: Gufang full_name: Zhao, Gufang id: 2BC2AC5E-F248-11E8-B48F-1D18A9856A87 last_name: Zhao citation: ama: 'Mirković I, Yang Y, Zhao G. Loop Grassmannians of Quivers and Affine Quantum Groups. In: Baranovskky V, Guay N, Schedler T, eds. Representation Theory and Algebraic Geometry. 1st ed. TM. Cham: Springer Nature; Birkhäuser; 2022:347-392. doi:10.1007/978-3-030-82007-7_8' apa: 'Mirković, I., Yang, Y., & Zhao, G. (2022). Loop Grassmannians of Quivers and Affine Quantum Groups. In V. Baranovskky, N. Guay, & T. Schedler (Eds.), Representation Theory and Algebraic Geometry (1st ed., pp. 347–392). Cham: Springer Nature; Birkhäuser. https://doi.org/10.1007/978-3-030-82007-7_8' chicago: 'Mirković, Ivan, Yaping Yang, and Gufang Zhao. “Loop Grassmannians of Quivers and Affine Quantum Groups.” In Representation Theory and Algebraic Geometry, edited by Vladimir Baranovskky, Nicolas Guay, and Travis Schedler, 1st ed., 347–92. TM. Cham: Springer Nature; Birkhäuser, 2022. https://doi.org/10.1007/978-3-030-82007-7_8.' ieee: 'I. Mirković, Y. Yang, and G. Zhao, “Loop Grassmannians of Quivers and Affine Quantum Groups,” in Representation Theory and Algebraic Geometry, 1st ed., V. Baranovskky, N. Guay, and T. Schedler, Eds. Cham: Springer Nature; Birkhäuser, 2022, pp. 347–392.' ista: 'Mirković I, Yang Y, Zhao G. 2022.Loop Grassmannians of Quivers and Affine Quantum Groups. In: Representation Theory and Algebraic Geometry. Trends in Mathematics, , 347–392.' mla: Mirković, Ivan, et al. “Loop Grassmannians of Quivers and Affine Quantum Groups.” Representation Theory and Algebraic Geometry, edited by Vladimir Baranovskky et al., 1st ed., Springer Nature; Birkhäuser, 2022, pp. 347–92, doi:10.1007/978-3-030-82007-7_8. short: I. Mirković, Y. Yang, G. Zhao, in:, V. Baranovskky, N. Guay, T. Schedler (Eds.), Representation Theory and Algebraic Geometry, 1st ed., Springer Nature; Birkhäuser, Cham, 2022, pp. 347–392. date_created: 2023-01-16T10:06:41Z date_published: 2022-06-16T00:00:00Z date_updated: 2023-01-27T07:07:31Z day: '16' department: - _id: TaHa doi: 10.1007/978-3-030-82007-7_8 ec_funded: 1 edition: '1' editor: - first_name: Vladimir full_name: Baranovskky, Vladimir last_name: Baranovskky - first_name: Nicolas full_name: Guay, Nicolas last_name: Guay - first_name: Travis full_name: Schedler, Travis last_name: Schedler external_id: arxiv: - '1810.10095' language: - iso: eng main_file_link: - open_access: '1' url: https://doi.org/10.48550/arXiv.1810.10095 month: '06' oa: 1 oa_version: Preprint page: 347-392 place: Cham project: - _id: 25E549F4-B435-11E9-9278-68D0E5697425 call_identifier: FP7 grant_number: '320593' name: Arithmetic and physics of Higgs moduli spaces publication: Representation Theory and Algebraic Geometry publication_identifier: eisbn: - '9783030820077' eissn: - 2297-024X isbn: - '9783030820060' issn: - 2297-0215 publication_status: published publisher: Springer Nature; Birkhäuser quality_controlled: '1' scopus_import: '1' series_title: TM status: public title: Loop Grassmannians of Quivers and Affine Quantum Groups type: book_chapter user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87 year: '2022' ... --- _id: '12304' abstract: - lang: eng text: 'We establish sharp criteria for the instantaneous propagation of free boundaries in solutions to the thin-film equation. The criteria are formulated in terms of the initial distribution of mass (as opposed to previous almost-optimal results), reflecting the fact that mass is a locally conserved quantity for the thin-film equation. In the regime of weak slippage, our criteria are at the same time necessary and sufficient. The proof of our upper bounds on free boundary propagation is based on a strategy of “propagation of degeneracy” down to arbitrarily small spatial scales: We combine estimates on the local mass and estimates on energies to show that “degeneracy” on a certain space-time cylinder entails “degeneracy” on a spatially smaller space-time cylinder with the same time horizon. The derivation of our lower bounds on free boundary propagation is based on a combination of a monotone quantity and almost optimal estimates established previously by the second author with a new estimate connecting motion of mass to entropy production.' acknowledgement: N. De Nitti acknowledges the kind hospitality of IST Austria within the framework of the ISTernship Summer Program 2018, during which most of the present article was written. N. DeNitti has received funding by The Austrian Agency for International Cooperation in Education &Research (OeAD-GmbH) via its financial support of the ISTernship Summer Program 2018. N.De Nitti would also like to thank Giuseppe Coclite, Giuseppe Devillanova, Giuseppe Florio, Sebastian Hensel, and Francesco Maddalena for several helpful conversations on topics related to this work. article_processing_charge: No article_type: original arxiv: 1 author: - first_name: Nicola full_name: De Nitti, Nicola last_name: De Nitti - first_name: Julian L full_name: Fischer, Julian L id: 2C12A0B0-F248-11E8-B48F-1D18A9856A87 last_name: Fischer orcid: 0000-0002-0479-558X citation: ama: De Nitti N, Fischer JL. Sharp criteria for the waiting time phenomenon in solutions to the thin-film equation. Communications in Partial Differential Equations. 2022;47(7):1394-1434. doi:10.1080/03605302.2022.2056702 apa: De Nitti, N., & Fischer, J. L. (2022). Sharp criteria for the waiting time phenomenon in solutions to the thin-film equation. Communications in Partial Differential Equations. Taylor & Francis. https://doi.org/10.1080/03605302.2022.2056702 chicago: De Nitti, Nicola, and Julian L Fischer. “Sharp Criteria for the Waiting Time Phenomenon in Solutions to the Thin-Film Equation.” Communications in Partial Differential Equations. Taylor & Francis, 2022. https://doi.org/10.1080/03605302.2022.2056702. ieee: N. De Nitti and J. L. Fischer, “Sharp criteria for the waiting time phenomenon in solutions to the thin-film equation,” Communications in Partial Differential Equations, vol. 47, no. 7. Taylor & Francis, pp. 1394–1434, 2022. ista: De Nitti N, Fischer JL. 2022. Sharp criteria for the waiting time phenomenon in solutions to the thin-film equation. Communications in Partial Differential Equations. 47(7), 1394–1434. mla: De Nitti, Nicola, and Julian L. Fischer. “Sharp Criteria for the Waiting Time Phenomenon in Solutions to the Thin-Film Equation.” Communications in Partial Differential Equations, vol. 47, no. 7, Taylor & Francis, 2022, pp. 1394–434, doi:10.1080/03605302.2022.2056702. short: N. De Nitti, J.L. Fischer, Communications in Partial Differential Equations 47 (2022) 1394–1434. date_created: 2023-01-16T10:06:50Z date_published: 2022-07-01T00:00:00Z date_updated: 2023-08-04T10:34:31Z day: '01' department: - _id: JuFi doi: 10.1080/03605302.2022.2056702 external_id: arxiv: - '1907.05342' isi: - '000805689800001' intvolume: ' 47' isi: 1 issue: '7' keyword: - Applied Mathematics - Analysis language: - iso: eng main_file_link: - open_access: '1' url: ' https://doi.org/10.48550/arXiv.1907.05342' month: '07' oa: 1 oa_version: Preprint page: 1394-1434 publication: Communications in Partial Differential Equations publication_identifier: eissn: - 1532-4133 issn: - 0360-5302 publication_status: published publisher: Taylor & Francis quality_controlled: '1' scopus_import: '1' status: public title: Sharp criteria for the waiting time phenomenon in solutions to the thin-film equation type: journal_article user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8 volume: 47 year: '2022' ... --- _id: '12305' abstract: - lang: eng text: This paper is concerned with the sharp interface limit for the Allen--Cahn equation with a nonlinear Robin boundary condition in a bounded smooth domain Ω⊂\R2. We assume that a diffuse interface already has developed and that it is in contact with the boundary ∂Ω. The boundary condition is designed in such a way that the limit problem is given by the mean curvature flow with constant α-contact angle. For α close to 90° we prove a local in time convergence result for well-prepared initial data for times when a smooth solution to the limit problem exists. Based on the latter we construct a suitable curvilinear coordinate system and carry out a rigorous asymptotic expansion for the Allen--Cahn equation with the nonlinear Robin boundary condition. Moreover, we show a spectral estimate for the corresponding linearized Allen--Cahn operator and with its aid we derive strong norm estimates for the difference of the exact and approximate solutions using a Gronwall-type argument. article_processing_charge: No article_type: original arxiv: 1 author: - first_name: Helmut full_name: Abels, Helmut last_name: Abels - first_name: Maximilian full_name: Moser, Maximilian id: a60047a9-da77-11eb-85b4-c4dc385ebb8c last_name: Moser citation: ama: Abels H, Moser M. Convergence of the Allen--Cahn equation with a nonlinear Robin boundary condition to mean curvature flow with contact angle close to 90°. SIAM Journal on Mathematical Analysis. 2022;54(1):114-172. doi:10.1137/21m1424925 apa: Abels, H., & Moser, M. (2022). Convergence of the Allen--Cahn equation with a nonlinear Robin boundary condition to mean curvature flow with contact angle close to 90°. SIAM Journal on Mathematical Analysis. Society for Industrial and Applied Mathematics. https://doi.org/10.1137/21m1424925 chicago: Abels, Helmut, and Maximilian Moser. “Convergence of the Allen--Cahn Equation with a Nonlinear Robin Boundary Condition to Mean Curvature Flow with Contact Angle Close to 90°.” SIAM Journal on Mathematical Analysis. Society for Industrial and Applied Mathematics, 2022. https://doi.org/10.1137/21m1424925. ieee: H. Abels and M. Moser, “Convergence of the Allen--Cahn equation with a nonlinear Robin boundary condition to mean curvature flow with contact angle close to 90°,” SIAM Journal on Mathematical Analysis, vol. 54, no. 1. Society for Industrial and Applied Mathematics, pp. 114–172, 2022. ista: Abels H, Moser M. 2022. Convergence of the Allen--Cahn equation with a nonlinear Robin boundary condition to mean curvature flow with contact angle close to 90°. SIAM Journal on Mathematical Analysis. 54(1), 114–172. mla: Abels, Helmut, and Maximilian Moser. “Convergence of the Allen--Cahn Equation with a Nonlinear Robin Boundary Condition to Mean Curvature Flow with Contact Angle Close to 90°.” SIAM Journal on Mathematical Analysis, vol. 54, no. 1, Society for Industrial and Applied Mathematics, 2022, pp. 114–72, doi:10.1137/21m1424925. short: H. Abels, M. Moser, SIAM Journal on Mathematical Analysis 54 (2022) 114–172. date_created: 2023-01-16T10:07:00Z date_published: 2022-01-04T00:00:00Z date_updated: 2023-08-04T10:34:56Z day: '04' department: - _id: JuFi doi: 10.1137/21m1424925 external_id: arxiv: - '2105.08434' isi: - '000762768000004' intvolume: ' 54' isi: 1 issue: '1' keyword: - Applied Mathematics - Computational Mathematics - Analysis language: - iso: eng main_file_link: - open_access: '1' url: ' https://doi.org/10.48550/arXiv.2105.08434' month: '01' oa: 1 oa_version: Preprint page: 114-172 publication: SIAM Journal on Mathematical Analysis publication_identifier: eissn: - 1095-7154 issn: - 0036-1410 publication_status: published publisher: Society for Industrial and Applied Mathematics quality_controlled: '1' scopus_import: '1' status: public title: Convergence of the Allen--Cahn equation with a nonlinear Robin boundary condition to mean curvature flow with contact angle close to 90° type: journal_article user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8 volume: 54 year: '2022' ... --- _id: '12307' abstract: - lang: eng text: Point-set topology is among the most abstract branches of mathematics in that it lacks tangible notions of distance, length, magnitude, order, and size. There is no shape, no geometry, no algebra, and no direction. Everything we are used to visualizing is gone. In the teaching and learning of mathematics, this can present a conundrum. Yet, this very property makes point set topology perfect for teaching and learning abstract mathematical concepts. It clears our minds of preconceived intuitions and expectations and forces us to think in new and creative ways. In this paper, we present guided investigations into topology through questions and thinking strategies that open up fascinating problems. They are intended for faculty who already teach or are thinking about teaching a class in topology or abstract mathematical reasoning for undergraduates. They can be used to build simple to challenging projects in topology, proofs, honors programs, and research experiences. article_processing_charge: No article_type: original author: - first_name: Barbara A. full_name: Shipman, Barbara A. last_name: Shipman - first_name: Elizabeth R full_name: Stephenson, Elizabeth R id: 2D04F932-F248-11E8-B48F-1D18A9856A87 last_name: Stephenson orcid: 0000-0002-6862-208X citation: ama: Shipman BA, Stephenson ER. Tangible topology through the lens of limits. PRIMUS. 2022;32(5):593-609. doi:10.1080/10511970.2021.1872750 apa: Shipman, B. A., & Stephenson, E. R. (2022). Tangible topology through the lens of limits. PRIMUS. Taylor & Francis. https://doi.org/10.1080/10511970.2021.1872750 chicago: Shipman, Barbara A., and Elizabeth R Stephenson. “Tangible Topology through the Lens of Limits.” PRIMUS. Taylor & Francis, 2022. https://doi.org/10.1080/10511970.2021.1872750. ieee: B. A. Shipman and E. R. Stephenson, “Tangible topology through the lens of limits,” PRIMUS, vol. 32, no. 5. Taylor & Francis, pp. 593–609, 2022. ista: Shipman BA, Stephenson ER. 2022. Tangible topology through the lens of limits. PRIMUS. 32(5), 593–609. mla: Shipman, Barbara A., and Elizabeth R. Stephenson. “Tangible Topology through the Lens of Limits.” PRIMUS, vol. 32, no. 5, Taylor & Francis, 2022, pp. 593–609, doi:10.1080/10511970.2021.1872750. short: B.A. Shipman, E.R. Stephenson, PRIMUS 32 (2022) 593–609. date_created: 2023-01-16T10:07:21Z date_published: 2022-05-28T00:00:00Z date_updated: 2023-01-30T13:02:30Z day: '28' department: - _id: HeEd - _id: GradSch doi: 10.1080/10511970.2021.1872750 intvolume: ' 32' issue: '5' keyword: - Education - General Mathematics language: - iso: eng month: '05' oa_version: None page: 593-609 publication: PRIMUS publication_identifier: eissn: - 1935-4053 issn: - 1051-1970 publication_status: published publisher: Taylor & Francis quality_controlled: '1' scopus_import: '1' status: public title: Tangible topology through the lens of limits type: journal_article user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87 volume: 32 year: '2022' ... --- _id: '12332' abstract: - lang: eng text: Activity of sensory neurons is driven not only by external stimuli but also by feedback signals from higher brain areas. Attention is one particularly important internal signal whose presumed role is to modulate sensory representations such that they only encode information currently relevant to the organism at minimal cost. This hypothesis has, however, not yet been expressed in a normative computational framework. Here, by building on normative principles of probabilistic inference and efficient coding, we developed a model of dynamic population coding in the visual cortex. By continuously adapting the sensory code to changing demands of the perceptual observer, an attention-like modulation emerges. This modulation can dramatically reduce the amount of neural activity without deteriorating the accuracy of task-specific inferences. Our results suggest that a range of seemingly disparate cortical phenomena such as intrinsic gain modulation, attention-related tuning modulation, and response variability could be manifestations of the same underlying principles, which combine efficient sensory coding with optimal probabilistic inference in dynamic environments. acknowledgement: "We thank Robbe Goris for generously providing figures from his work and Ann M. Hermundstad for helpful discussions.\r\nGT & WM were supported by the Austrian Science Fund Standalone Grant P 34015 \"Efficient Coding with Biophysical Realism\" (https://pf.fwf.ac.at/) WM was additionally supported by the European Union’s Horizon 2020 research and innovation programme under the Marie Skłodowska-Curie Grant Agreement No. 754411 (https://ec.europa.eu/research/mariecurieactions/). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript." article_processing_charge: No article_type: original author: - first_name: Wiktor F full_name: Mlynarski, Wiktor F id: 358A453A-F248-11E8-B48F-1D18A9856A87 last_name: Mlynarski - first_name: Gašper full_name: Tkačik, Gašper id: 3D494DCA-F248-11E8-B48F-1D18A9856A87 last_name: Tkačik orcid: '1' citation: ama: Mlynarski WF, Tkačik G. Efficient coding theory of dynamic attentional modulation. PLoS Biology. 2022;20(12):e3001889. doi:10.1371/journal.pbio.3001889 apa: Mlynarski, W. F., & Tkačik, G. (2022). Efficient coding theory of dynamic attentional modulation. PLoS Biology. Public Library of Science. https://doi.org/10.1371/journal.pbio.3001889 chicago: Mlynarski, Wiktor F, and Gašper Tkačik. “Efficient Coding Theory of Dynamic Attentional Modulation.” PLoS Biology. Public Library of Science, 2022. https://doi.org/10.1371/journal.pbio.3001889. ieee: W. F. Mlynarski and G. Tkačik, “Efficient coding theory of dynamic attentional modulation,” PLoS Biology, vol. 20, no. 12. Public Library of Science, p. e3001889, 2022. ista: Mlynarski WF, Tkačik G. 2022. Efficient coding theory of dynamic attentional modulation. PLoS Biology. 20(12), e3001889. mla: Mlynarski, Wiktor F., and Gašper Tkačik. “Efficient Coding Theory of Dynamic Attentional Modulation.” PLoS Biology, vol. 20, no. 12, Public Library of Science, 2022, p. e3001889, doi:10.1371/journal.pbio.3001889. short: W.F. Mlynarski, G. Tkačik, PLoS Biology 20 (2022) e3001889. date_created: 2023-01-22T23:00:55Z date_published: 2022-12-21T00:00:00Z date_updated: 2023-08-03T14:23:49Z day: '21' ddc: - '570' department: - _id: GaTk doi: 10.1371/journal.pbio.3001889 ec_funded: 1 external_id: isi: - '000925192000001' file: - access_level: open_access checksum: 5d7f1111a87e5f2c1bf92f8886738894 content_type: application/pdf creator: dernst date_created: 2023-01-23T08:46:40Z date_updated: 2023-01-23T08:46:40Z file_id: '12337' file_name: 2022_PloSBiology_Mlynarski.pdf file_size: 4248838 relation: main_file success: 1 file_date_updated: 2023-01-23T08:46:40Z has_accepted_license: '1' intvolume: ' 20' isi: 1 issue: '12' language: - iso: eng month: '12' oa: 1 oa_version: Published Version page: e3001889 project: - _id: 626c45b5-2b32-11ec-9570-e509828c1ba6 grant_number: P34015 name: Efficient coding with biophysical realism - _id: 260C2330-B435-11E9-9278-68D0E5697425 call_identifier: H2020 grant_number: '754411' name: ISTplus - Postdoctoral Fellowships publication: PLoS Biology publication_identifier: eissn: - 1545-7885 publication_status: published publisher: Public Library of Science quality_controlled: '1' scopus_import: '1' status: public title: Efficient coding theory of dynamic attentional modulation tmp: image: /images/cc_by.png legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0) short: CC BY (4.0) type: journal_article user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8 volume: 20 year: '2022' ... --- _id: '12333' abstract: - lang: eng text: Together, copy-number and point mutations form the basis for most evolutionary novelty, through the process of gene duplication and divergence. While a plethora of genomic data reveals the long-term fate of diverging coding sequences and their cis-regulatory elements, little is known about the early dynamics around the duplication event itself. In microorganisms, selection for increased gene expression often drives the expansion of gene copy-number mutations, which serves as a crude adaptation, prior to divergence through refining point mutations. Using a simple synthetic genetic reporter system that can distinguish between copy-number and point mutations, we study their early and transient adaptive dynamics in real time in Escherichia coli. We find two qualitatively different routes of adaptation, depending on the level of functional improvement needed. In conditions of high gene expression demand, the two mutation types occur as a combination. However, under low gene expression demand, copy-number and point mutations are mutually exclusive; here, owing to their higher frequency, adaptation is dominated by copy-number mutations, in a process we term amplification hindrance. Ultimately, due to high reversal rates and pleiotropic cost, copy-number mutations may not only serve as a crude and transient adaptation, but also constrain sequence divergence over evolutionary time scales. acknowledgement: "We are grateful to N Barton, F Kondrashov, M Lagator, M Pleska, R Roemhild, D Siekhaus, and G\r\nTkacik for input on the manuscript and to K Tomasek for help with flow cytometry." article_number: e82240 article_processing_charge: No article_type: original author: - first_name: Isabella full_name: Tomanek, Isabella id: 3981F020-F248-11E8-B48F-1D18A9856A87 last_name: Tomanek orcid: 0000-0001-6197-363X - first_name: Calin C full_name: Guet, Calin C id: 47F8433E-F248-11E8-B48F-1D18A9856A87 last_name: Guet orcid: 0000-0001-6220-2052 citation: ama: Tomanek I, Guet CC. Adaptation dynamics between copynumber and point mutations. eLife. 2022;11. doi:10.7554/ELIFE.82240 apa: Tomanek, I., & Guet, C. C. (2022). Adaptation dynamics between copynumber and point mutations. ELife. eLife Sciences Publications. https://doi.org/10.7554/ELIFE.82240 chicago: Tomanek, Isabella, and Calin C Guet. “Adaptation Dynamics between Copynumber and Point Mutations.” ELife. eLife Sciences Publications, 2022. https://doi.org/10.7554/ELIFE.82240. ieee: I. Tomanek and C. C. Guet, “Adaptation dynamics between copynumber and point mutations,” eLife, vol. 11. eLife Sciences Publications, 2022. ista: Tomanek I, Guet CC. 2022. Adaptation dynamics between copynumber and point mutations. eLife. 11, e82240. mla: Tomanek, Isabella, and Calin C. Guet. “Adaptation Dynamics between Copynumber and Point Mutations.” ELife, vol. 11, e82240, eLife Sciences Publications, 2022, doi:10.7554/ELIFE.82240. short: I. Tomanek, C.C. Guet, ELife 11 (2022). date_created: 2023-01-22T23:00:55Z date_published: 2022-12-22T00:00:00Z date_updated: 2023-08-03T14:23:07Z day: '22' ddc: - '570' department: - _id: CaGu doi: 10.7554/ELIFE.82240 external_id: isi: - '000912674700001' file: - access_level: open_access checksum: 9321fd5f06ff59d5e2d33daee84b3da1 content_type: application/pdf creator: dernst date_created: 2023-01-23T08:56:21Z date_updated: 2023-01-23T08:56:21Z file_id: '12338' file_name: 2022_eLife_Tomanek.pdf file_size: 8835954 relation: main_file success: 1 file_date_updated: 2023-01-23T08:56:21Z has_accepted_license: '1' intvolume: ' 11' isi: 1 language: - iso: eng month: '12' oa: 1 oa_version: Published Version publication: eLife publication_identifier: eissn: - 2050-084X publication_status: published publisher: eLife Sciences Publications quality_controlled: '1' related_material: link: - relation: software url: https://doi.org/10.5281/zenodo.6974122 record: - id: '12339' relation: research_data status: public scopus_import: '1' status: public title: Adaptation dynamics between copynumber and point mutations tmp: image: /images/cc_by.png legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0) short: CC BY (4.0) type: journal_article user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8 volume: 11 year: '2022' ... --- _id: '12339' abstract: - lang: eng text: 'Copy-number and point mutations form the basis for most evolutionary novelty through the process of gene duplication and divergence. While a plethora of genomic sequence data reveals the long-term fate of diverging coding sequences and their cis-regulatory elements, little is known about the early dynamics around the duplication event itself. In microorganisms, selection for increased gene expression often drives the expansion of gene copy-number mutations, which serves as a crude adaptation, prior to divergence through refining point mutations. Using a simple synthetic genetic system that allows us to distinguish copy-number and point mutations, we study their early and transient adaptive dynamics in real-time in Escherichia coli. We find two qualitatively different routes of adaptation depending on the level of functional improvement selected for: In conditions of high gene expression demand, the two types of mutations occur as a combination. Under low gene expression demand, negative epistasis between the two types of mutations renders them mutually exclusive. Thus, owing to their higher frequency, adaptation is dominated by copy-number mutations. Ultimately, due to high rates of reversal and pleiotropic cost, copy-number mutations may not only serve as a crude and transient adaptation but also constrain sequence divergence over evolutionary time scales.' article_processing_charge: No author: - first_name: Isabella full_name: Tomanek, Isabella id: 3981F020-F248-11E8-B48F-1D18A9856A87 last_name: Tomanek orcid: 0000-0001-6197-363X - first_name: Calin C full_name: Guet, Calin C id: 47F8433E-F248-11E8-B48F-1D18A9856A87 last_name: Guet orcid: 0000-0001-6220-2052 citation: ama: Tomanek I, Guet CC. Flow cytometry YFP and CFP data and deep sequencing data of populations evolving in galactose. 2022. doi:10.5061/dryad.rfj6q57ds apa: Tomanek, I., & Guet, C. C. (2022). Flow cytometry YFP and CFP data and deep sequencing data of populations evolving in galactose. Dryad. https://doi.org/10.5061/dryad.rfj6q57ds chicago: Tomanek, Isabella, and Calin C Guet. “Flow Cytometry YFP and CFP Data and Deep Sequencing Data of Populations Evolving in Galactose.” Dryad, 2022. https://doi.org/10.5061/dryad.rfj6q57ds. ieee: I. Tomanek and C. C. Guet, “Flow cytometry YFP and CFP data and deep sequencing data of populations evolving in galactose.” Dryad, 2022. ista: Tomanek I, Guet CC. 2022. Flow cytometry YFP and CFP data and deep sequencing data of populations evolving in galactose, Dryad, 10.5061/dryad.rfj6q57ds. mla: Tomanek, Isabella, and Calin C. Guet. Flow Cytometry YFP and CFP Data and Deep Sequencing Data of Populations Evolving in Galactose. Dryad, 2022, doi:10.5061/dryad.rfj6q57ds. short: I. Tomanek, C.C. Guet, (2022). date_created: 2023-01-23T09:00:37Z date_published: 2022-12-23T00:00:00Z date_updated: 2023-08-03T14:23:06Z day: '23' ddc: - '570' department: - _id: CaGu doi: 10.5061/dryad.rfj6q57ds main_file_link: - open_access: '1' url: https://doi.org/10.5061/dryad.rfj6q57ds month: '12' oa: 1 oa_version: Published Version publisher: Dryad related_material: record: - id: '12333' relation: used_in_publication status: public status: public title: Flow cytometry YFP and CFP data and deep sequencing data of populations evolving in galactose type: research_data_reference user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87 year: '2022' ... --- _id: '12358' abstract: - lang: eng text: "The complex yarn structure of knitted and woven fabrics gives rise to both a mechanical and\r\nvisual complexity. The small-scale interactions of yarns colliding with and pulling on each\r\nother result in drastically different large-scale stretching and bending behavior, introducing\r\nanisotropy, curling, and more. While simulating cloth as individual yarns can reproduce this\r\ncomplexity and match the quality of real fabric, it may be too computationally expensive for\r\nlarge fabrics. On the other hand, continuum-based approaches do not need to discretize the\r\ncloth at a stitch-level, but it is non-trivial to find a material model that would replicate the\r\nlarge-scale behavior of yarn fabrics, and they discard the intricate visual detail. In this thesis,\r\nwe discuss three methods to try and bridge the gap between small-scale and large-scale yarn\r\nmechanics using numerical homogenization: fitting a continuum model to periodic yarn simulations, adding mechanics-aware yarn detail onto thin-shell simulations, and quantitatively\r\nfitting yarn parameters to physical measurements of real fabric.\r\nTo start, we present a method for animating yarn-level cloth effects using a thin-shell solver.\r\nWe first use a large number of periodic yarn-level simulations to build a model of the potential\r\nenergy density of the cloth, and then use it to compute forces in a thin-shell simulator. The\r\nresulting simulations faithfully reproduce expected effects like the stiffening of woven fabrics\r\nand the highly deformable nature and anisotropy of knitted fabrics at a fraction of the cost of\r\nfull yarn-level simulation.\r\nWhile our thin-shell simulations are able to capture large-scale yarn mechanics, they lack\r\nthe rich visual detail of yarn-level simulations. Therefore, we propose a method to animate\r\nyarn-level cloth geometry on top of an underlying deforming mesh in a mechanics-aware\r\nfashion in real time. Using triangle strains to interpolate precomputed yarn geometry, we are\r\nable to reproduce effects such as knit loops tightening under stretching at negligible cost.\r\nFinally, we introduce a methodology for inverse-modeling of yarn-level mechanics of cloth,\r\nbased on the mechanical response of fabrics in the real world. We compile a database from\r\nphysical tests of several knitted fabrics used in the textile industry spanning diverse physical\r\nproperties like stiffness, nonlinearity, and anisotropy. We then develop a system for approximating these mechanical responses with yarn-level cloth simulation, using homogenized\r\nshell models to speed up computation and adding some small-but-necessary extensions to\r\nyarn-level models used in computer graphics.\r\n" acknowledged_ssus: - _id: SSU alternative_title: - ISTA Thesis article_processing_charge: No author: - first_name: Georg full_name: Sperl, Georg id: 4DD40360-F248-11E8-B48F-1D18A9856A87 last_name: Sperl citation: ama: 'Sperl G. Homogenizing yarn simulations: Large-scale mechanics, small-scale detail, and quantitative fitting. 2022. doi:10.15479/at:ista:12103' apa: 'Sperl, G. (2022). Homogenizing yarn simulations: Large-scale mechanics, small-scale detail, and quantitative fitting. Institute of Science and Technology Austria. https://doi.org/10.15479/at:ista:12103' chicago: 'Sperl, Georg. “Homogenizing Yarn Simulations: Large-Scale Mechanics, Small-Scale Detail, and Quantitative Fitting.” Institute of Science and Technology Austria, 2022. https://doi.org/10.15479/at:ista:12103.' ieee: 'G. Sperl, “Homogenizing yarn simulations: Large-scale mechanics, small-scale detail, and quantitative fitting,” Institute of Science and Technology Austria, 2022.' ista: 'Sperl G. 2022. Homogenizing yarn simulations: Large-scale mechanics, small-scale detail, and quantitative fitting. Institute of Science and Technology Austria.' mla: 'Sperl, Georg. Homogenizing Yarn Simulations: Large-Scale Mechanics, Small-Scale Detail, and Quantitative Fitting. Institute of Science and Technology Austria, 2022, doi:10.15479/at:ista:12103.' short: 'G. Sperl, Homogenizing Yarn Simulations: Large-Scale Mechanics, Small-Scale Detail, and Quantitative Fitting, Institute of Science and Technology Austria, 2022.' date_created: 2023-01-24T10:49:46Z date_published: 2022-09-22T00:00:00Z date_updated: 2024-02-28T12:57:46Z day: '22' ddc: - '000' - '620' degree_awarded: PhD department: - _id: GradSch - _id: ChWo doi: 10.15479/at:ista:12103 ec_funded: 1 file: - access_level: open_access checksum: 083722acbb8115e52e3b0fdec6226769 content_type: application/pdf creator: cchlebak date_created: 2023-01-25T12:04:41Z date_updated: 2023-02-02T09:29:57Z description: 'This is the main PDF file of the thesis. File size: 105 MB' file_id: '12371' file_name: thesis_gsperl.pdf file_size: 104497530 relation: main_file title: Thesis - access_level: open_access checksum: 511f82025e5fcb70bff4731d6896ca07 content_type: application/pdf creator: cchlebak date_created: 2023-02-02T09:33:37Z date_updated: 2023-02-02T09:33:37Z description: This version of the thesis uses stronger image compression for a smaller file size of 23MB. file_id: '12483' file_name: thesis_gsperl_compressed.pdf file_size: 23183710 relation: main_file title: Thesis (compressed 23MB) - access_level: open_access checksum: ed4cb85225eedff761c25bddfc37a2ed content_type: application/x-zip-compressed creator: cchlebak date_created: 2023-02-02T09:39:25Z date_updated: 2023-02-02T09:39:25Z file_id: '12484' file_name: thesis-source.zip file_size: 98382247 relation: source_file file_date_updated: 2023-02-02T09:39:25Z has_accepted_license: '1' language: - iso: eng month: '09' oa: 1 oa_version: Published Version page: '138' project: - _id: 2533E772-B435-11E9-9278-68D0E5697425 call_identifier: H2020 grant_number: '638176' name: Efficient Simulation of Natural Phenomena at Extremely Large Scales publication_identifier: isbn: - 978-3-99078-020-6 issn: - 2663-337X publication_status: published publisher: Institute of Science and Technology Austria related_material: record: - id: '11736' relation: part_of_dissertation status: public - id: '9818' relation: part_of_dissertation status: public - id: '8385' relation: part_of_dissertation status: public status: public supervisor: - first_name: Christopher J full_name: Wojtan, Christopher J id: 3C61F1D2-F248-11E8-B48F-1D18A9856A87 last_name: Wojtan orcid: 0000-0001-6646-5546 title: 'Homogenizing yarn simulations: Large-scale mechanics, small-scale detail, and quantitative fitting' type: dissertation user_id: 8b945eb4-e2f2-11eb-945a-df72226e66a9 year: '2022' ... --- _id: '12364' abstract: - lang: eng text: "Autism spectrum disorders (ASDs) are a group of neurodevelopmental disorders character\x02ized by behavioral symptoms such as problems in social communication and interaction, as\r\nwell as repetitive, restricted behaviors and interests. These disorders show a high degree\r\nof heritability and hundreds of risk genes have been identifed using high throughput\r\nsequencing technologies. This genetic heterogeneity has hampered eforts in understanding\r\nthe pathogenesis of ASD but at the same time given rise to the concept of convergent\r\nmechanisms. Previous studies have identifed that risk genes for ASD broadly converge\r\nonto specifc functional categories with transcriptional regulation being one of the biggest\r\ngroups. In this thesis, I focus on this subgroup of genes and investigate the gene regulatory\r\nconsequences of some of them in the context of neurodevelopment.\r\nFirst, we showed that mutations in the ASD and intellectual disability risk gene Setd5 lead\r\nto perturbations of gene regulatory programs in early cell fate specifcation. In addition,\r\nadult animals display abnormal learning behavior which is mirrored at the transcriptional\r\nlevel by altered activity dependent regulation of postsynaptic gene expression. Lastly,\r\nwe link the regulatory function of Setd5 to its interaction with the Paf1 and the NCoR\r\ncomplex.\r\nSecond, by modeling the heterozygous loss of the top ASD gene CHD8 in human cerebral\r\norganoids we demonstrate profound changes in the developmental trajectories of both\r\ninhibitory and excitatory neurons using single cell RNA-sequencing. While the former\r\nwere generated earlier in CHD8+/- organoids, the generation of the latter was shifted to\r\nlater times in favor of a prolonged progenitor expansion phase and ultimately increased\r\norganoid size.\r\nFinally, by modeling heterozygous mutations for four ASD associated chromatin modifers,\r\nASH1L, KDM6B, KMT5B, and SETD5 in human cortical spheroids we show evidence of\r\nregulatory convergence across three of those genes. We observe a shift from dorsal cortical\r\nexcitatory neuron fates towards partially ventralized cell types resembling cells from the\r\nlateral ganglionic eminence. As this project is still ongoing at the time of writing, future\r\nexperiments will aim at elucidating the regulatory mechanisms underlying this shift with\r\nthe aim of linking these three ASD risk genes through biological convergence." alternative_title: - ISTA Thesis article_processing_charge: No author: - first_name: Christoph full_name: Dotter, Christoph id: 4C66542E-F248-11E8-B48F-1D18A9856A87 last_name: Dotter orcid: 0000-0002-9033-9096 citation: ama: Dotter C. Transcriptional consequences of mutations in genes associated with Autism Spectrum Disorder. 2022. doi:10.15479/at:ista:12094 apa: Dotter, C. (2022). Transcriptional consequences of mutations in genes associated with Autism Spectrum Disorder. Institute of Science and Technology Austria. https://doi.org/10.15479/at:ista:12094 chicago: Dotter, Christoph. “Transcriptional Consequences of Mutations in Genes Associated with Autism Spectrum Disorder.” Institute of Science and Technology Austria, 2022. https://doi.org/10.15479/at:ista:12094. ieee: C. Dotter, “Transcriptional consequences of mutations in genes associated with Autism Spectrum Disorder,” Institute of Science and Technology Austria, 2022. ista: Dotter C. 2022. Transcriptional consequences of mutations in genes associated with Autism Spectrum Disorder. Institute of Science and Technology Austria. mla: Dotter, Christoph. Transcriptional Consequences of Mutations in Genes Associated with Autism Spectrum Disorder. Institute of Science and Technology Austria, 2022, doi:10.15479/at:ista:12094. short: C. Dotter, Transcriptional Consequences of Mutations in Genes Associated with Autism Spectrum Disorder, Institute of Science and Technology Austria, 2022. date_created: 2023-01-24T13:09:57Z date_published: 2022-09-19T00:00:00Z date_updated: 2023-11-16T13:10:22Z day: '19' ddc: - '570' degree_awarded: PhD department: - _id: GradSch - _id: GaNo doi: 10.15479/at:ista:12094 ec_funded: 1 file: - access_level: open_access checksum: 896f4cac9adb6d3f26a6605772f4e1a3 content_type: application/pdf creator: cchlebak date_created: 2023-01-24T13:15:45Z date_updated: 2023-09-20T22:30:03Z embargo: 2023-09-19 file_id: '12365' file_name: 220923_Thesis_CDotter_Final.pdf file_size: 20457465 relation: main_file - access_level: closed checksum: ad01bb20da163be6893b7af832e58419 content_type: application/x-zip-compressed creator: cchlebak date_created: 2023-02-02T09:15:35Z date_updated: 2023-09-20T22:30:03Z embargo_to: open_access file_id: '12482' file_name: latex_source_CDotter_Thesis_2022.zip file_size: 22433512 relation: source_file file_date_updated: 2023-09-20T22:30:03Z has_accepted_license: '1' language: - iso: eng month: '09' oa: 1 oa_version: Published Version page: '152' project: - _id: 254BA948-B435-11E9-9278-68D0E5697425 grant_number: '401299' name: Probing development and reversibility of autism spectrum disorders - _id: 9B91375C-BA93-11EA-9121-9846C619BF3A grant_number: '707964' name: Critical windows and reversibility of ASD associated with mutations in chromatin remodelers - _id: 25444568-B435-11E9-9278-68D0E5697425 call_identifier: H2020 grant_number: '715508' name: Probing the Reversibility of Autism Spectrum Disorders by Employing in vivo and in vitro Models - _id: 2690FEAC-B435-11E9-9278-68D0E5697425 call_identifier: FWF grant_number: I04205 name: Identification of converging Molecular Pathways Across Chromatinopathies as Targets for Therapy publication_identifier: issn: - 2663-337X publication_status: published publisher: Institute of Science and Technology Austria related_material: record: - id: '3' relation: part_of_dissertation status: public - id: '11160' relation: part_of_dissertation status: public status: public supervisor: - first_name: Gaia full_name: Novarino, Gaia id: 3E57A680-F248-11E8-B48F-1D18A9856A87 last_name: Novarino orcid: 0000-0002-7673-7178 title: Transcriptional consequences of mutations in genes associated with Autism Spectrum Disorder type: dissertation user_id: 8b945eb4-e2f2-11eb-945a-df72226e66a9 year: '2022' ... --- _id: '12366' abstract: - lang: eng text: "Recent substantial advances in the feld of superconducting circuits have shown its\r\npotential as a leading platform for future quantum computing. In contrast to classical\r\ncomputers based on bits that are represented by a single binary value, 0 or 1, quantum\r\nbits (or qubits) can be in a superposition of both. Thus, quantum computers can store\r\nand handle more information at the same time and a quantum advantage has already\r\nbeen demonstrated for two types of computational tasks. Rapid progress in academic\r\nand industry labs accelerates the development of superconducting processors which may\r\nsoon fnd applications in complex computations, chemical simulations, cryptography, and\r\noptimization. Now that these machines are scaled up to tackle such problems the questions\r\nof qubit interconnects and networks becomes very relevant. How to route signals on-chip\r\nbetween diferent processor components? What is the most efcient way to entangle\r\nqubits? And how to then send and process entangled signals between distant cryostats\r\nhosting superconducting processors?\r\nIn this thesis, we are looking for solutions to these problems by studying the collective\r\nbehavior of superconducting qubit ensembles. We frst demonstrate on-demand tunable\r\ndirectional scattering of microwave photons from a pair of qubits in a waveguide. Such a\r\ndevice can route microwave photons on-chip with a high diode efciency. Then we focus\r\non studying ultra-strong coupling regimes between light (microwave photons) and matter\r\n(superconducting qubits), a regime that could be promising for extremely fast multi-qubit\r\nentanglement generation. Finally, we show coherent pulse storage and periodic revivals\r\nin a fve qubit ensemble strongly coupled to a resonator. Such a reconfgurable storage\r\ndevice could be used as part of a quantum repeater that is needed for longer-distance\r\nquantum communication.\r\nThe achieved high degree of control over multi-qubit ensembles highlights not only the\r\nbeautiful physics of circuit quantum electrodynamics, it also represents the frst step\r\ntoward new quantum simulation and communication methods, and certain techniques\r\nmay also fnd applications in future superconducting quantum computing hardware.\r\n" acknowledged_ssus: - _id: NanoFab - _id: M-Shop - _id: EM-Fac alternative_title: - ISTA Thesis article_processing_charge: No author: - first_name: Elena full_name: Redchenko, Elena id: 2C21D6E8-F248-11E8-B48F-1D18A9856A87 last_name: Redchenko citation: ama: Redchenko E. Controllable states of superconducting Qubit ensembles. 2022. doi:10.15479/at:ista:12132 apa: Redchenko, E. (2022). Controllable states of superconducting Qubit ensembles. Institute of Science and Technology Austria. https://doi.org/10.15479/at:ista:12132 chicago: Redchenko, Elena. “Controllable States of Superconducting Qubit Ensembles.” Institute of Science and Technology Austria, 2022. https://doi.org/10.15479/at:ista:12132. ieee: E. Redchenko, “Controllable states of superconducting Qubit ensembles,” Institute of Science and Technology Austria, 2022. ista: Redchenko E. 2022. Controllable states of superconducting Qubit ensembles. Institute of Science and Technology Austria. mla: Redchenko, Elena. Controllable States of Superconducting Qubit Ensembles. Institute of Science and Technology Austria, 2022, doi:10.15479/at:ista:12132. short: E. Redchenko, Controllable States of Superconducting Qubit Ensembles, Institute of Science and Technology Austria, 2022. date_created: 2023-01-25T09:17:02Z date_published: 2022-09-26T00:00:00Z date_updated: 2024-08-07T07:11:56Z day: '26' ddc: - '530' degree_awarded: PhD department: - _id: GradSch - _id: JoFi doi: 10.15479/at:ista:12132 ec_funded: 1 file: - access_level: open_access checksum: 39eabb1e006b41335f17f3b29af09648 content_type: application/pdf creator: cchlebak date_created: 2023-01-25T09:41:49Z date_updated: 2023-01-26T23:30:44Z embargo: 2022-12-28 file_id: '12367' file_name: Final_Thesis_ES_Redchenko.pdf file_size: 56076868 relation: main_file file_date_updated: 2023-01-26T23:30:44Z has_accepted_license: '1' language: - iso: eng month: '09' oa: 1 oa_version: Published Version page: '168' project: - _id: 2564DBCA-B435-11E9-9278-68D0E5697425 call_identifier: H2020 grant_number: '665385' name: International IST Doctoral Program - _id: 26336814-B435-11E9-9278-68D0E5697425 call_identifier: H2020 grant_number: '758053' name: A Fiber Optic Transceiver for Superconducting Qubits - _id: 237CBA6C-32DE-11EA-91FC-C7463DDC885E call_identifier: H2020 grant_number: '862644' name: Quantum readout techniques and technologies publication_identifier: isbn: - 978-3-99078-024-4 issn: - 2663-337X publication_status: published publisher: Institute of Science and Technology Austria status: public supervisor: - first_name: Johannes M full_name: Fink, Johannes M id: 4B591CBA-F248-11E8-B48F-1D18A9856A87 last_name: Fink orcid: 0000-0001-8112-028X title: Controllable states of superconducting Qubit ensembles type: dissertation user_id: 8b945eb4-e2f2-11eb-945a-df72226e66a9 year: '2022' ... --- _id: '12368' abstract: - lang: eng text: "Metazoan development relies on the formation and remodeling of cell-cell contacts. The \r\nbinding of adhesion receptors and remodeling of the actomyosin cell cortex at cell-cell \r\ninteraction sites have been implicated in cell-cell contact formation. Yet, how these two \r\nprocesses functionally interact to drive cell-cell contact expansion and strengthening \r\nremains unclear. Here, we study how primary germ layer progenitor cells from zebrafish \r\nbind to supported lipid bilayers (SLB) functionalized with E-cadherin ectodomains as an \r\nassay system for monitoring cell-cell contact formation at high spatiotemporal resolution. \r\nWe show that cell-cell contact formation represents a two-tiered process: E-cadherin\x02mediated downregulation of the small GTPase RhoA at the forming contact leads to both \r\ndepletion of Myosin-2 and decrease of F-actin. This is followed by centrifugal actin \r\nnetwork flows at the contact triggered by a sharp gradient of Myosin-2 at the rim of the \r\ncontact zone, with Myosin-2 displaying higher cortical localization outside than inside of \r\nthe contact. These centrifugal cortical actin flows, in turn, not only further dilute the actin \r\nnetwork at the contact disc, but also lead to an accumulation of both F-actin and E\x02cadherin at the contact rim. Eventually, this combination of actomyosin downregulation \r\nand flows at the contact contribute to the characteristic molecular organization implicated \r\nin contact formation and maintenance: depletion of cortical actomyosin at the contact disc, \r\ndriving contact expansion by lowering interfacial tension at the contact, and accumulation \r\nof both E-cadherin and F-actin at the contact rim, mechanically linking the contractile \r\ncortices of the adhering cells. Thus, using a biomimetic assay, we exemplify how \r\nadhesion signaling and cell mechanics function together to modulate the spatial \r\norganization of cell-cell contacts." acknowledged_ssus: - _id: LifeSc - _id: Bio - _id: NanoFab alternative_title: - ISTA Thesis article_processing_charge: No author: - first_name: Feyza N full_name: Arslan, Feyza N id: 49DA7910-F248-11E8-B48F-1D18A9856A87 last_name: Arslan orcid: 0000-0001-5809-9566 citation: ama: Arslan FN. Remodeling of E-cadherin-mediated contacts via cortical  flows. 2022. doi:10.15479/at:ista:12153 apa: Arslan, F. N. (2022). Remodeling of E-cadherin-mediated contacts via cortical  flows. Institute of Science and Technology Austria. https://doi.org/10.15479/at:ista:12153 chicago: Arslan, Feyza N. “Remodeling of E-Cadherin-Mediated Contacts via Cortical  Flows.” Institute of Science and Technology Austria, 2022. https://doi.org/10.15479/at:ista:12153. ieee: F. N. Arslan, “Remodeling of E-cadherin-mediated contacts via cortical  flows,” Institute of Science and Technology Austria, 2022. ista: Arslan FN. 2022. Remodeling of E-cadherin-mediated contacts via cortical  flows. Institute of Science and Technology Austria. mla: Arslan, Feyza N. Remodeling of E-Cadherin-Mediated Contacts via Cortical  Flows. Institute of Science and Technology Austria, 2022, doi:10.15479/at:ista:12153. short: F.N. Arslan, Remodeling of E-Cadherin-Mediated Contacts via Cortical  Flows, Institute of Science and Technology Austria, 2022. date_created: 2023-01-25T10:43:24Z date_published: 2022-09-29T00:00:00Z date_updated: 2023-08-08T13:14:10Z day: '29' ddc: - '570' degree_awarded: PhD department: - _id: GradSch - _id: CaHe doi: 10.15479/at:ista:12153 ec_funded: 1 file: - access_level: open_access checksum: e54a3e69b83ebf166544164afd25608e content_type: application/pdf creator: cchlebak date_created: 2023-01-25T10:52:46Z date_updated: 2023-01-25T10:52:46Z file_id: '12369' file_name: THESIS_FINAL_FArslan_pdfa.pdf file_size: 14581024 relation: main_file success: 1 file_date_updated: 2023-01-25T10:52:46Z has_accepted_license: '1' language: - iso: eng month: '09' oa: 1 oa_version: Published Version page: '113' project: - _id: 260F1432-B435-11E9-9278-68D0E5697425 call_identifier: H2020 grant_number: '742573' name: Interaction and feedback between cell mechanics and fate specification in vertebrate gastrulation publication_identifier: isbn: - ' 978-3-99078-025-1 ' issn: - 2663-337X publication_status: published publisher: Institute of Science and Technology Austria related_material: record: - id: '9350' relation: part_of_dissertation status: public status: public supervisor: - first_name: Carl-Philipp J full_name: Heisenberg, Carl-Philipp J id: 39427864-F248-11E8-B48F-1D18A9856A87 last_name: Heisenberg orcid: 0000-0002-0912-4566 title: Remodeling of E-cadherin-mediated contacts via cortical flows tmp: image: /images/cc_by.png legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0) short: CC BY (4.0) type: dissertation user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87 year: '2022' ... --- _id: '12378' abstract: - lang: eng text: "Environmental cues influence the highly dynamic morphology of microglia. Strategies to \r\ncharacterize these changes usually involve user-selected morphometric features, which \r\npreclude the identification of a spectrum of context-dependent morphological phenotypes. \r\nHere, we develop MorphOMICs, a topological data analysis approach, which enables semi\x02automatic mapping of microglial morphology into an atlas of cue-dependent phenotypes,\r\novercomes feature-selection bias and minimizes biological variability. \r\nFirst, with MorphOMICs we derive the morphological spectrum of microglia across seven \r\nbrain regions during postnatal development and in two distinct Alzheimer’s disease \r\ndegeneration mouse models. We uncover region-specific and sexually dimorphic\r\nmorphological trajectories, with females showing an earlier morphological shift than males in \r\nthe degenerating brain. Overall, we demonstrate that both long primary- and short terminal \r\nprocesses provide distinct insights to morphological phenotypes. Moreover, using machine \r\nlearning to map novel condition on the spectrum, we observe that microglia morphologies \r\nreflect a dose-dependent adaptation upon ketamine anesthesia and do not recover to control \r\nmorphologies.\r\nNext, we took advantage of MorphOMICs to build a high-resolution and layer-specific map of \r\nmicroglial morphological spectrum in the retina, covering postnatal development and rd10 \r\ndegeneration. Here, following photoreceptor death, microglia assume an early development\x02like morphology. Finally, we map microglial morphology following optic nerve crush on the \r\nretinal spectrum and observe a layer- and sex-dependent response. \r\nOverall, MorphOMICs opens a new perspective to analyze microglial morphology across \r\nmultiple conditions, and provides a novel tool to characterize microglial morphology beyond \r\nthe traditionally dichotomized view of microglia." acknowledged_ssus: - _id: PreCl - _id: Bio - _id: ScienComp alternative_title: - ISTA Thesis article_processing_charge: No author: - first_name: Gloria full_name: Colombo, Gloria id: 3483CF6C-F248-11E8-B48F-1D18A9856A87 last_name: Colombo orcid: 0000-0001-9434-8902 citation: ama: Colombo G. MorphOMICs, a tool for mapping microglial morphology, reveals brain region- and sex-dependent phenotypes. 2022. doi:10.15479/at:ista:12378 apa: Colombo, G. (2022). MorphOMICs, a tool for mapping microglial morphology, reveals brain region- and sex-dependent phenotypes. Institute of Science and Technology Austria. https://doi.org/10.15479/at:ista:12378 chicago: Colombo, Gloria. “MorphOMICs, a Tool for Mapping Microglial Morphology, Reveals Brain Region- and Sex-Dependent Phenotypes.” Institute of Science and Technology Austria, 2022. https://doi.org/10.15479/at:ista:12378. ieee: G. Colombo, “MorphOMICs, a tool for mapping microglial morphology, reveals brain region- and sex-dependent phenotypes,” Institute of Science and Technology Austria, 2022. ista: Colombo G. 2022. MorphOMICs, a tool for mapping microglial morphology, reveals brain region- and sex-dependent phenotypes. Institute of Science and Technology Austria. mla: Colombo, Gloria. MorphOMICs, a Tool for Mapping Microglial Morphology, Reveals Brain Region- and Sex-Dependent Phenotypes. Institute of Science and Technology Austria, 2022, doi:10.15479/at:ista:12378. short: G. Colombo, MorphOMICs, a Tool for Mapping Microglial Morphology, Reveals Brain Region- and Sex-Dependent Phenotypes, Institute of Science and Technology Austria, 2022. date_created: 2023-01-25T14:27:43Z date_published: 2022-11-11T00:00:00Z date_updated: 2023-08-04T09:40:37Z day: '11' ddc: - '570' degree_awarded: PhD department: - _id: GradSch - _id: SaSi doi: 10.15479/at:ista:12378 ec_funded: 1 file: - access_level: closed checksum: 8cd3ddfe9b53381dcf086023d8d8893a content_type: application/vnd.openxmlformats-officedocument.wordprocessingml.document creator: cchlebak date_created: 2023-01-25T14:31:32Z date_updated: 2023-04-12T22:30:03Z embargo_to: open_access file_id: '12379' file_name: Gloria_Colombo_Thesis.docx file_size: 23890382 relation: source_file - access_level: open_access checksum: 8af4319c18b516e8758e9a6cb02b103b content_type: application/pdf creator: cchlebak date_created: 2023-01-25T14:31:36Z date_updated: 2023-04-12T22:30:03Z embargo: 2023-04-11 file_id: '12380' file_name: Gloria_Colombo_Thesis.pdf file_size: 13802421 relation: main_file file_date_updated: 2023-04-12T22:30:03Z has_accepted_license: '1' language: - iso: eng month: '11' oa: 1 oa_version: Published Version page: '142' project: - _id: 2564DBCA-B435-11E9-9278-68D0E5697425 call_identifier: H2020 grant_number: '665385' name: International IST Doctoral Program publication_identifier: issn: - 2663-337X publication_status: published publisher: Institute of Science and Technology Austria related_material: record: - id: '12244' relation: part_of_dissertation status: public status: public supervisor: - first_name: Sandra full_name: Siegert, Sandra id: 36ACD32E-F248-11E8-B48F-1D18A9856A87 last_name: Siegert orcid: 0000-0001-8635-0877 title: MorphOMICs, a tool for mapping microglial morphology, reveals brain region- and sex-dependent phenotypes tmp: image: /images/cc_by.png legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0) short: CC BY (4.0) type: dissertation user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87 year: '2022' ... --- _id: '12390' abstract: - lang: eng text: "The scope of this thesis is to study quantum systems exhibiting a continuous symmetry that\r\nis broken on the level of the corresponding effective theory. In particular we are going to\r\ninvestigate translation-invariant Bose gases in the mean field limit, effectively described by\r\nthe Hartree functional, and the Fröhlich Polaron in the regime of strong coupling, effectively\r\ndescribed by the Pekar functional. The latter is a model describing the interaction between a\r\ncharged particle and the optical modes of a polar crystal. Regarding the former, we assume in\r\naddition that the particles in the gas are unconfined, and typically we will consider particles\r\nthat are subject to an attractive interaction. In both cases the ground state energy of the\r\nHamiltonian is not a proper eigenvalue due to the underlying translation-invariance, while on\r\nthe contrary there exists a whole invariant orbit of minimizers for the corresponding effective\r\nfunctionals. Both, the absence of proper eigenstates and the broken symmetry of the effective\r\ntheory, make the study significantly more involved and it is the content of this thesis to\r\ndevelop a frameworks which allows for a systematic way to circumvent these issues.\r\nIt is a well-established result that the ground state energy of Bose gases in the mean field limit,\r\nas well as the ground state energy of the Fröhlich Polaron in the regime of strong coupling, is\r\nto leading order given by the minimal energy of the corresponding effective theory. As part\r\nof this thesis we identify the sub-leading term in the expansion of the ground state energy,\r\nwhich can be interpreted as the quantum correction to the classical energy, since the effective\r\ntheories under consideration can be seen as classical counterparts.\r\nWe are further going to establish an asymptotic expression for the energy-momentum relation\r\nof the Fröhlich Polaron in the strong coupling limit. In the regime of suitably small momenta,\r\nthis asymptotic expression agrees with the energy-momentum relation of a free particle having\r\nan effectively increased mass, and we find that this effectively increased mass agrees with the\r\nconjectured value in the physics literature.\r\nIn addition we will discuss two unrelated papers written by the author during his stay at ISTA\r\nin the appendix. The first one concerns the realization of anyons, which are quasi-particles\r\nacquiring a non-trivial phase under the exchange of two particles, as molecular impurities.\r\nThe second one provides a classification of those vector fields defined on a given manifold\r\nthat can be written as the gradient of a given functional with respect to a suitable metric,\r\nprovided that some mild smoothness assumptions hold. This classification is subsequently\r\nused to identify those quantum Markov semigroups that can be written as a gradient flow of\r\nthe relative entropy.\r\n" alternative_title: - ISTA Thesis article_processing_charge: No author: - first_name: Morris full_name: Brooks, Morris id: B7ECF9FC-AA38-11E9-AC9A-0930E6697425 last_name: Brooks orcid: 0000-0002-6249-0928 citation: ama: Brooks M. Translation-invariant quantum systems with effectively broken symmetry. 2022. doi:10.15479/at:ista:12390 apa: Brooks, M. (2022). Translation-invariant quantum systems with effectively broken symmetry. Institute of Science and Technology Austria. https://doi.org/10.15479/at:ista:12390 chicago: Brooks, Morris. “Translation-Invariant Quantum Systems with Effectively Broken Symmetry.” Institute of Science and Technology Austria, 2022. https://doi.org/10.15479/at:ista:12390. ieee: M. Brooks, “Translation-invariant quantum systems with effectively broken symmetry,” Institute of Science and Technology Austria, 2022. ista: Brooks M. 2022. Translation-invariant quantum systems with effectively broken symmetry. Institute of Science and Technology Austria. mla: Brooks, Morris. Translation-Invariant Quantum Systems with Effectively Broken Symmetry. Institute of Science and Technology Austria, 2022, doi:10.15479/at:ista:12390. short: M. Brooks, Translation-Invariant Quantum Systems with Effectively Broken Symmetry, Institute of Science and Technology Austria, 2022. date_created: 2023-01-26T10:00:42Z date_published: 2022-12-15T00:00:00Z date_updated: 2023-08-07T13:32:09Z day: '15' ddc: - '500' degree_awarded: PhD department: - _id: GradSch - _id: RoSe doi: 10.15479/at:ista:12390 ec_funded: 1 file: - access_level: open_access checksum: b31460e937f33b557abb40ebef02b567 content_type: application/pdf creator: cchlebak date_created: 2023-01-26T10:02:34Z date_updated: 2023-01-26T10:02:34Z file_id: '12391' file_name: Brooks_Thesis.pdf file_size: 3095225 relation: main_file success: 1 - access_level: closed checksum: 9751869fa5e7981588ad4228f4fd4bd6 content_type: application/octet-stream creator: cchlebak date_created: 2023-01-26T10:02:42Z date_updated: 2023-01-26T10:02:42Z file_id: '12392' file_name: Brooks_Thesis.tex file_size: 809842 relation: source_file file_date_updated: 2023-01-26T10:02:42Z has_accepted_license: '1' language: - iso: eng month: '12' oa: 1 oa_version: Published Version page: '196' project: - _id: 25C6DC12-B435-11E9-9278-68D0E5697425 call_identifier: H2020 grant_number: '694227' name: Analysis of quantum many-body systems publication_identifier: issn: - 2663-337X publication_status: published publisher: Institute of Science and Technology Austria related_material: record: - id: '9005' relation: part_of_dissertation status: public status: public supervisor: - first_name: Robert full_name: Seiringer, Robert id: 4AFD0470-F248-11E8-B48F-1D18A9856A87 last_name: Seiringer orcid: 0000-0002-6781-0521 title: Translation-invariant quantum systems with effectively broken symmetry tmp: image: /images/cc_by_nc_sa.png legal_code_url: https://creativecommons.org/licenses/by-nc-sa/4.0/legalcode name: Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) short: CC BY-NC-SA (4.0) type: dissertation user_id: 8b945eb4-e2f2-11eb-945a-df72226e66a9 year: '2022' ... --- _id: '12401' abstract: - lang: eng text: "Detachment of the cancer cells from the bulk of the tumor is the first step of metastasis, which\r\nis the primary cause of cancer related deaths. It is unclear, which factors contribute to this step.\r\nRecent studies indicate a crucial role of the tumor microenvironment in malignant\r\ntransformation and metastasis. Studying cancer cell invasion and detachments quantitatively in\r\nthe context of its physiological microenvironment is technically challenging. Especially, precise\r\ncontrol of microenvironmental properties in vivo is currently not possible. Here, I studied the\r\nrole of microenvironment geometry in the invasion and detachment of cancer cells from the\r\nbulk with a simplistic and reductionist approach. In this approach, I engineered microfluidic\r\ndevices to mimic a pseudo 3D extracellular matrix environment, where I was able to\r\nquantitatively tune the geometrical configuration of the microenvironment and follow tumor\r\ncells with fluorescence live imaging. To aid quantitative analysis I developed a widely applicable\r\nsoftware application to automatically analyze and visualize particle tracking data.\r\nQuantitative analysis of tumor cell invasion in isotropic and anisotropic microenvironments\r\nshowed that heterogeneity in the microenvironment promotes faster invasion and more\r\nfrequent detachment of cells. These observations correlated with overall higher speed of cells at\r\nthe edge of the bulk of the cells. In heterogeneous microenvironments cells preferentially\r\npassed through larger pores, thus invading areas of least resistance and generating finger-like\r\ninvasive structures. The detachments occurred mostly at the tips of these structures.\r\nTo investigate the potential mechanism, we established a two dimensional model to simulate\r\nactive Brownian particles representing the cell nuclei dynamics. These simulations backed our in\r\nvitro observations without the need of precise fitting the simulation parameters. Our model\r\nsuggests the importance of the pore heterogeneity in the direction perpendicular to the\r\norientation of bias field (lateral heterogeneity), which causes the interface roughening." alternative_title: - ISTA Thesis article_processing_charge: No author: - first_name: Saren full_name: Tasciyan, Saren id: 4323B49C-F248-11E8-B48F-1D18A9856A87 last_name: Tasciyan orcid: 0000-0003-1671-393X citation: ama: Tasciyan S. Role of microenvironment heterogeneity in cancer cell invasion. 2022. doi:10.15479/at:ista:12401 apa: Tasciyan, S. (2022). Role of microenvironment heterogeneity in cancer cell invasion. Institute of Science and Technology Austria. https://doi.org/10.15479/at:ista:12401 chicago: Tasciyan, Saren. “Role of Microenvironment Heterogeneity in Cancer Cell Invasion.” Institute of Science and Technology Austria, 2022. https://doi.org/10.15479/at:ista:12401. ieee: S. Tasciyan, “Role of microenvironment heterogeneity in cancer cell invasion,” Institute of Science and Technology Austria, 2022. ista: Tasciyan S. 2022. Role of microenvironment heterogeneity in cancer cell invasion. Institute of Science and Technology Austria. mla: Tasciyan, Saren. Role of Microenvironment Heterogeneity in Cancer Cell Invasion. Institute of Science and Technology Austria, 2022, doi:10.15479/at:ista:12401. short: S. Tasciyan, Role of Microenvironment Heterogeneity in Cancer Cell Invasion, Institute of Science and Technology Austria, 2022. date_created: 2023-01-26T11:55:16Z date_published: 2022-12-22T00:00:00Z date_updated: 2024-09-10T12:04:26Z day: '22' ddc: - '610' degree_awarded: PhD department: - _id: GradSch - _id: MiSi doi: 10.15479/at:ista:12401 file: - access_level: open_access checksum: cc4a2b4a7e3c4ee8ef7f2dbf909b12bd content_type: application/pdf creator: cchlebak date_created: 2023-01-26T11:58:14Z date_updated: 2023-12-21T23:30:03Z embargo: 2023-12-20 file_id: '12402' file_name: PhD-Thesis_Saren Tasciyan_formatted_aftercrash_fixed_600dpi_95pc_final_PDFA3b.pdf file_size: 42059787 relation: main_file - access_level: closed checksum: f1b4ca98b8ab0cb043b1830971e9bd9c content_type: application/x-zip-compressed creator: cchlebak date_created: 2023-01-26T12:00:10Z date_updated: 2023-12-21T23:30:03Z embargo_to: open_access file_id: '12403' file_name: Source Files - Saren Tasciyan - PhD Thesis.zip file_size: 261256696 relation: source_file file_date_updated: 2023-12-21T23:30:03Z has_accepted_license: '1' language: - iso: eng month: '12' oa: 1 oa_version: Published Version page: '105' publication_identifier: issn: - 2663-337X publication_status: published publisher: Institute of Science and Technology Austria related_material: record: - id: '679' relation: part_of_dissertation status: public - id: '10703' relation: part_of_dissertation status: public - id: '7885' relation: part_of_dissertation status: public - id: '9429' relation: part_of_dissertation status: public status: public supervisor: - first_name: Michael K full_name: Sixt, Michael K id: 41E9FBEA-F248-11E8-B48F-1D18A9856A87 last_name: Sixt orcid: 0000-0002-6620-9179 title: Role of microenvironment heterogeneity in cancer cell invasion type: dissertation user_id: 8b945eb4-e2f2-11eb-945a-df72226e66a9 year: '2022' ... --- _id: '12431' abstract: - lang: eng text: This paper presents a new representation of curve dynamics, with applications to vortex filaments in fluid dynamics. Instead of representing these filaments with explicit curve geometry and Lagrangian equations of motion, we represent curves implicitly with a new co-dimensional 2 level set description. Our implicit representation admits several redundant mathematical degrees of freedom in both the configuration and the dynamics of the curves, which can be tailored specifically to improve numerical robustness, in contrast to naive approaches for implicit curve dynamics that suffer from overwhelming numerical stability problems. Furthermore, we note how these hidden degrees of freedom perfectly map to a Clebsch representation in fluid dynamics. Motivated by these observations, we introduce untwisted level set functions and non-swirling dynamics which successfully regularize sources of numerical instability, particularly in the twisting modes around curve filaments. A consequence is a novel simulation method which produces stable dynamics for large numbers of interacting vortex filaments and effortlessly handles topological changes and re-connection events. acknowledgement: We thank the visual computing group at IST Austria for their valuable discussions and feedback. Houdini Education licenses were provided by SideFX software. This project was funded in part by the European Research Council (ERC Consolidator Grant 101045083 CoDiNA). article_number: '241' article_processing_charge: No article_type: original author: - first_name: Sadashige full_name: Ishida, Sadashige id: 6F7C4B96-A8E9-11E9-A7CA-09ECE5697425 last_name: Ishida - first_name: Christopher J full_name: Wojtan, Christopher J id: 3C61F1D2-F248-11E8-B48F-1D18A9856A87 last_name: Wojtan orcid: 0000-0001-6646-5546 - first_name: Albert full_name: Chern, Albert last_name: Chern citation: ama: Ishida S, Wojtan C, Chern A. Hidden degrees of freedom in implicit vortex filaments. ACM Transactions on Graphics. 2022;41(6). doi:10.1145/3550454.3555459 apa: Ishida, S., Wojtan, C., & Chern, A. (2022). Hidden degrees of freedom in implicit vortex filaments. ACM Transactions on Graphics. Association for Computing Machinery. https://doi.org/10.1145/3550454.3555459 chicago: Ishida, Sadashige, Chris Wojtan, and Albert Chern. “Hidden Degrees of Freedom in Implicit Vortex Filaments.” ACM Transactions on Graphics. Association for Computing Machinery, 2022. https://doi.org/10.1145/3550454.3555459. ieee: S. Ishida, C. Wojtan, and A. Chern, “Hidden degrees of freedom in implicit vortex filaments,” ACM Transactions on Graphics, vol. 41, no. 6. Association for Computing Machinery, 2022. ista: Ishida S, Wojtan C, Chern A. 2022. Hidden degrees of freedom in implicit vortex filaments. ACM Transactions on Graphics. 41(6), 241. mla: Ishida, Sadashige, et al. “Hidden Degrees of Freedom in Implicit Vortex Filaments.” ACM Transactions on Graphics, vol. 41, no. 6, 241, Association for Computing Machinery, 2022, doi:10.1145/3550454.3555459. short: S. Ishida, C. Wojtan, A. Chern, ACM Transactions on Graphics 41 (2022). date_created: 2023-01-29T23:00:59Z date_published: 2022-12-01T00:00:00Z date_updated: 2023-08-04T09:37:23Z day: '01' ddc: - '000' department: - _id: ChWo doi: 10.1145/3550454.3555459 external_id: isi: - '000891651900061' file: - access_level: open_access checksum: a2fba257fdefe0e747182be6c0f7c70c content_type: application/pdf creator: dernst date_created: 2023-01-30T07:15:48Z date_updated: 2023-01-30T07:15:48Z file_id: '12433' file_name: 2022_ACM_Ishida.pdf file_size: 15551202 relation: main_file success: 1 file_date_updated: 2023-01-30T07:15:48Z has_accepted_license: '1' intvolume: ' 41' isi: 1 issue: '6' language: - iso: eng month: '12' oa: 1 oa_version: Published Version project: - _id: 34bc2376-11ca-11ed-8bc3-9a3b3961a088 grant_number: '101045083' name: Computational Discovery of Numerical Algorithms for Animation and Simulation of Natural Phenomena publication: ACM Transactions on Graphics publication_identifier: eissn: - 1557-7368 issn: - 0730-0301 publication_status: published publisher: Association for Computing Machinery quality_controlled: '1' scopus_import: '1' status: public title: Hidden degrees of freedom in implicit vortex filaments tmp: image: /images/cc_by.png legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0) short: CC BY (4.0) type: journal_article user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8 volume: 41 year: '2022' ... --- _id: '12432' abstract: - lang: eng text: "We present CertifyHAM, a deterministic algorithm that takes a graph G as input and either finds a Hamilton cycle of G or outputs that such a cycle does not exist. If G ∼ G(n, p) and p ≥\r\n100 log n/n then the expected running time of CertifyHAM is O(n/p) which is best possible. This improves upon previous results due to Gurevich and Shelah, Thomason and Alon, and\r\nKrivelevich, who proved analogous results for p being constant, p ≥ 12n −1/3 and p ≥ 70n\r\n−1/2 respectively." acknowledgement: "This project has received funding from the European Union’s Horizon 2020\r\nresearch and innovation programme under the Marie Skłodowska-Curie grant\r\nagreement No 101034413" article_processing_charge: No author: - first_name: Michael full_name: Anastos, Michael id: 0b2a4358-bb35-11ec-b7b9-e3279b593dbb last_name: Anastos citation: ama: 'Anastos M. Solving the Hamilton cycle problem fast on average. In: 63rd Annual IEEE Symposium on Foundations of Computer Science. Vol 2022-October. Institute of Electrical and Electronics Engineers; 2022:919-930. doi:10.1109/FOCS54457.2022.00091' apa: 'Anastos, M. (2022). Solving the Hamilton cycle problem fast on average. In 63rd Annual IEEE Symposium on Foundations of Computer Science (Vol. 2022–October, pp. 919–930). Denver, CO, United States: Institute of Electrical and Electronics Engineers. https://doi.org/10.1109/FOCS54457.2022.00091' chicago: Anastos, Michael. “Solving the Hamilton Cycle Problem Fast on Average.” In 63rd Annual IEEE Symposium on Foundations of Computer Science, 2022–October:919–30. Institute of Electrical and Electronics Engineers, 2022. https://doi.org/10.1109/FOCS54457.2022.00091. ieee: M. Anastos, “Solving the Hamilton cycle problem fast on average,” in 63rd Annual IEEE Symposium on Foundations of Computer Science, Denver, CO, United States, 2022, vol. 2022–October, pp. 919–930. ista: 'Anastos M. 2022. Solving the Hamilton cycle problem fast on average. 63rd Annual IEEE Symposium on Foundations of Computer Science. FOCS: Symposium on Foundations of Computer Science vol. 2022–October, 919–930.' mla: Anastos, Michael. “Solving the Hamilton Cycle Problem Fast on Average.” 63rd Annual IEEE Symposium on Foundations of Computer Science, vol. 2022–October, Institute of Electrical and Electronics Engineers, 2022, pp. 919–30, doi:10.1109/FOCS54457.2022.00091. short: M. Anastos, in:, 63rd Annual IEEE Symposium on Foundations of Computer Science, Institute of Electrical and Electronics Engineers, 2022, pp. 919–930. conference: end_date: 2022-11-03 location: Denver, CO, United States name: 'FOCS: Symposium on Foundations of Computer Science' start_date: 2022-10-31 date_created: 2023-01-29T23:00:59Z date_published: 2022-12-01T00:00:00Z date_updated: 2023-08-04T09:37:56Z day: '01' department: - _id: MaKw doi: 10.1109/FOCS54457.2022.00091 ec_funded: 1 external_id: isi: - '000909382900084' isi: 1 language: - iso: eng month: '12' oa_version: None page: 919-930 project: - _id: fc2ed2f7-9c52-11eb-aca3-c01059dda49c call_identifier: H2020 grant_number: '101034413' name: 'IST-BRIDGE: International postdoctoral program' publication: 63rd Annual IEEE Symposium on Foundations of Computer Science publication_identifier: isbn: - '9781665455190' issn: - 0272-5428 publication_status: published publisher: Institute of Electrical and Electronics Engineers quality_controlled: '1' scopus_import: '1' status: public title: Solving the Hamilton cycle problem fast on average type: conference user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8 volume: 2022-October year: '2022' ...