[{"user_id":"c635000d-4b10-11ee-a964-aac5a93f6ac1","language":[{"iso":"eng"}],"date_updated":"2023-09-05T15:18:36Z","scopus_import":"1","related_material":{"record":[{"id":"12205","relation":"other","status":"public"}]},"main_file_link":[{"url":"https://doi.org/10.1245/s10434-022-12681-z","open_access":"1"}],"keyword":["Oncology","Surgery"],"author":[{"last_name":"Glajzer","full_name":"Glajzer, Jacek","first_name":"Jacek"},{"first_name":"Dan Cacsire","full_name":"Castillo-Tong, Dan Cacsire","last_name":"Castillo-Tong"},{"full_name":"Richter, Rolf","last_name":"Richter","first_name":"Rolf"},{"first_name":"Ignace","last_name":"Vergote","full_name":"Vergote, Ignace"},{"full_name":"Kulbe, Hagen","last_name":"Kulbe","first_name":"Hagen"},{"full_name":"Vanderstichele, Adriaan","last_name":"Vanderstichele","first_name":"Adriaan"},{"first_name":"Ilary","last_name":"Ruscito","full_name":"Ruscito, Ilary"},{"last_name":"Trillsch","full_name":"Trillsch, Fabian","first_name":"Fabian"},{"first_name":"Alexander","last_name":"Mustea","full_name":"Mustea, Alexander"},{"full_name":"Kreuzinger, Caroline","last_name":"Kreuzinger","first_name":"Caroline","id":"382077BA-F248-11E8-B48F-1D18A9856A87"},{"last_name":"Gourley","full_name":"Gourley, Charlie","first_name":"Charlie"},{"full_name":"Gabra, Hani","last_name":"Gabra","first_name":"Hani"},{"last_name":"Taube","full_name":"Taube, Eliane T.","first_name":"Eliane T."},{"first_name":"Oliver","full_name":"Dorigo, Oliver","last_name":"Dorigo"},{"first_name":"David","full_name":"Horst, David","last_name":"Horst"},{"full_name":"Keunecke, Carlotta","last_name":"Keunecke","first_name":"Carlotta"},{"first_name":"Joanna","full_name":"Baum, Joanna","last_name":"Baum"},{"full_name":"Angelotti, Timothy","last_name":"Angelotti","first_name":"Timothy"},{"full_name":"Sehouli, Jalid","last_name":"Sehouli","first_name":"Jalid"},{"first_name":"Elena Ioana","last_name":"Braicu","full_name":"Braicu, Elena Ioana"}],"status":"public","publisher":"Springer Nature","_id":"12115","publication_status":"published","external_id":{"isi":["000879151800001"]},"oa_version":"Published Version","type":"journal_article","month":"01","year":"2023","isi":1,"publication_identifier":{"eissn":["1534-4681"],"issn":["1068-9265"]},"article_type":"original","department":[{"_id":"JoDa"}],"volume":30,"acknowledgement":"This work was supported by European Commission’s Seventh Framework Programme under Grant Agreement No. 279113 (OCTIPS; www.octips.eu).","publication":"Annals of Surgical Oncology","day":"01","date_published":"2023-01-01T00:00:00Z","intvolume":"        30","doi":"10.1245/s10434-022-12681-z","article_processing_charge":"No","oa":1,"quality_controlled":"1","citation":{"ama":"Glajzer J, Castillo-Tong DC, Richter R, et al. ASO Visual Abstract: Impact of BRCA mutation status on tumor dissemination pattern, surgical outcome, and patient survival in primary and recurrent high-grade serous ovarian cancer (HGSOC). A multicenter, retrospective study of the ovarian cancer therapy—innovative models prolong survival (OCTIPS) consortium. <i>Annals of Surgical Oncology</i>. 2023;30:46-47. doi:<a href=\"https://doi.org/10.1245/s10434-022-12681-z\">10.1245/s10434-022-12681-z</a>","ista":"Glajzer J, Castillo-Tong DC, Richter R, Vergote I, Kulbe H, Vanderstichele A, Ruscito I, Trillsch F, Mustea A, Kreuzinger C, Gourley C, Gabra H, Taube ET, Dorigo O, Horst D, Keunecke C, Baum J, Angelotti T, Sehouli J, Braicu EI. 2023. ASO Visual Abstract: Impact of BRCA mutation status on tumor dissemination pattern, surgical outcome, and patient survival in primary and recurrent high-grade serous ovarian cancer (HGSOC). A multicenter, retrospective study of the ovarian cancer therapy—innovative models prolong survival (OCTIPS) consortium. Annals of Surgical Oncology. 30, 46–47.","short":"J. Glajzer, D.C. Castillo-Tong, R. Richter, I. Vergote, H. Kulbe, A. Vanderstichele, I. Ruscito, F. Trillsch, A. Mustea, C. Kreuzinger, C. Gourley, H. Gabra, E.T. Taube, O. Dorigo, D. Horst, C. Keunecke, J. Baum, T. Angelotti, J. Sehouli, E.I. Braicu, Annals of Surgical Oncology 30 (2023) 46–47.","ieee":"J. Glajzer <i>et al.</i>, “ASO Visual Abstract: Impact of BRCA mutation status on tumor dissemination pattern, surgical outcome, and patient survival in primary and recurrent high-grade serous ovarian cancer (HGSOC). A multicenter, retrospective study of the ovarian cancer therapy—innovative models prolong survival (OCTIPS) consortium,” <i>Annals of Surgical Oncology</i>, vol. 30. Springer Nature, pp. 46–47, 2023.","apa":"Glajzer, J., Castillo-Tong, D. C., Richter, R., Vergote, I., Kulbe, H., Vanderstichele, A., … Braicu, E. I. (2023). ASO Visual Abstract: Impact of BRCA mutation status on tumor dissemination pattern, surgical outcome, and patient survival in primary and recurrent high-grade serous ovarian cancer (HGSOC). A multicenter, retrospective study of the ovarian cancer therapy—innovative models prolong survival (OCTIPS) consortium. <i>Annals of Surgical Oncology</i>. Springer Nature. <a href=\"https://doi.org/10.1245/s10434-022-12681-z\">https://doi.org/10.1245/s10434-022-12681-z</a>","chicago":"Glajzer, Jacek, Dan Cacsire Castillo-Tong, Rolf Richter, Ignace Vergote, Hagen Kulbe, Adriaan Vanderstichele, Ilary Ruscito, et al. “ASO Visual Abstract: Impact of BRCA Mutation Status on Tumor Dissemination Pattern, Surgical Outcome, and Patient Survival in Primary and Recurrent High-Grade Serous Ovarian Cancer (HGSOC). A Multicenter, Retrospective Study of the Ovarian Cancer Therapy—Innovative Models Prolong Survival (OCTIPS) Consortium.” <i>Annals of Surgical Oncology</i>. Springer Nature, 2023. <a href=\"https://doi.org/10.1245/s10434-022-12681-z\">https://doi.org/10.1245/s10434-022-12681-z</a>.","mla":"Glajzer, Jacek, et al. “ASO Visual Abstract: Impact of BRCA Mutation Status on Tumor Dissemination Pattern, Surgical Outcome, and Patient Survival in Primary and Recurrent High-Grade Serous Ovarian Cancer (HGSOC). A Multicenter, Retrospective Study of the Ovarian Cancer Therapy—Innovative Models Prolong Survival (OCTIPS) Consortium.” <i>Annals of Surgical Oncology</i>, vol. 30, Springer Nature, 2023, pp. 46–47, doi:<a href=\"https://doi.org/10.1245/s10434-022-12681-z\">10.1245/s10434-022-12681-z</a>."},"date_created":"2023-01-12T11:56:22Z","page":"46-47","title":"ASO Visual Abstract: Impact of BRCA mutation status on tumor dissemination pattern, surgical outcome, and patient survival in primary and recurrent high-grade serous ovarian cancer (HGSOC). A multicenter, retrospective study of the ovarian cancer therapy—innovative models prolong survival (OCTIPS) consortium"},{"publication_status":"published","external_id":{"isi":["000900762000001"],"pmid":["36433653"]},"issue":"6","_id":"12159","ddc":["570"],"type":"journal_article","oa_version":"Published Version","file":[{"date_updated":"2023-08-16T08:15:41Z","content_type":"application/pdf","access_level":"open_access","date_created":"2023-08-16T08:15:41Z","success":1,"file_size":7144607,"checksum":"b10e0f8fa3dc4d72aaf77a557200978a","file_name":"2023_MolecularEcology_Shipilina.pdf","relation":"main_file","creator":"dernst","file_id":"14062"}],"publisher":"Wiley","article_type":"original","department":[{"_id":"NiBa"}],"project":[{"grant_number":"P32166","name":"The maintenance of alternative adaptive peaks in snapdragons","_id":"05959E1C-7A3F-11EA-A408-12923DDC885E"},{"grant_number":"Z211","call_identifier":"FWF","name":"The Wittgenstein Prize","_id":"25F42A32-B435-11E9-9278-68D0E5697425"},{"grant_number":"101055327","name":"Understanding the evolution of continuous genomes","_id":"bd6958e0-d553-11ed-ba76-86eba6a76c00"}],"year":"2023","month":"03","publication_identifier":{"issn":["0962-1083"],"eissn":["1365-294X"]},"isi":1,"scopus_import":"1","keyword":["Genetics","Ecology","Evolution","Behavior and Systematics"],"abstract":[{"lang":"eng","text":"The term “haplotype block” is commonly used in the developing field of haplotype-based inference methods. We argue that the term should be defined based on the structure of the Ancestral Recombination Graph (ARG), which contains complete information on the ancestry of a sample. We use simulated examples to demonstrate key features of the relationship between haplotype blocks and ancestral structure, emphasizing the stochasticity of the processes that generate them. Even the simplest cases of neutrality or of a “hard” selective sweep produce a rich structure, often missed by commonly used statistics. We highlight a number of novel methods for inferring haplotype structure, based on the full ARG, or on a sequence of trees, and illustrate how they can be used to define haplotype blocks using an empirical data set. While the advent of new, computationally efficient methods makes it possible to apply these concepts broadly, they (and additional new methods) could benefit from adding features to explore haplotype blocks, as we define them. Understanding and applying the concept of the haplotype block will be essential to fully exploit long and linked-read sequencing technologies."}],"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","language":[{"iso":"eng"}],"date_updated":"2023-08-16T08:18:47Z","status":"public","author":[{"id":"428A94B0-F248-11E8-B48F-1D18A9856A87","first_name":"Daria","last_name":"Shipilina","full_name":"Shipilina, Daria","orcid":"0000-0002-1145-9226"},{"orcid":"0000-0002-4530-8469","full_name":"Pal, Arka","last_name":"Pal","first_name":"Arka","id":"6AAB2240-CA9A-11E9-9C1A-D9D1E5697425"},{"last_name":"Stankowski","full_name":"Stankowski, Sean","id":"43161670-5719-11EA-8025-FABC3DDC885E","first_name":"Sean"},{"first_name":"Yingguang Frank","last_name":"Chan","full_name":"Chan, Yingguang Frank"},{"last_name":"Barton","full_name":"Barton, Nicholas H","orcid":"0000-0002-8548-5240","first_name":"Nicholas H","id":"4880FE40-F248-11E8-B48F-1D18A9856A87"}],"quality_controlled":"1","date_created":"2023-01-12T12:09:17Z","citation":{"ieee":"D. Shipilina, A. Pal, S. Stankowski, Y. F. Chan, and N. H. Barton, “On the origin and structure of haplotype blocks,” <i>Molecular Ecology</i>, vol. 32, no. 6. Wiley, pp. 1441–1457, 2023.","ista":"Shipilina D, Pal A, Stankowski S, Chan YF, Barton NH. 2023. On the origin and structure of haplotype blocks. Molecular Ecology. 32(6), 1441–1457.","short":"D. Shipilina, A. Pal, S. Stankowski, Y.F. Chan, N.H. Barton, Molecular Ecology 32 (2023) 1441–1457.","ama":"Shipilina D, Pal A, Stankowski S, Chan YF, Barton NH. On the origin and structure of haplotype blocks. <i>Molecular Ecology</i>. 2023;32(6):1441-1457. doi:<a href=\"https://doi.org/10.1111/mec.16793\">10.1111/mec.16793</a>","chicago":"Shipilina, Daria, Arka Pal, Sean Stankowski, Yingguang Frank Chan, and Nicholas H Barton. “On the Origin and Structure of Haplotype Blocks.” <i>Molecular Ecology</i>. Wiley, 2023. <a href=\"https://doi.org/10.1111/mec.16793\">https://doi.org/10.1111/mec.16793</a>.","apa":"Shipilina, D., Pal, A., Stankowski, S., Chan, Y. F., &#38; Barton, N. H. (2023). On the origin and structure of haplotype blocks. <i>Molecular Ecology</i>. Wiley. <a href=\"https://doi.org/10.1111/mec.16793\">https://doi.org/10.1111/mec.16793</a>","mla":"Shipilina, Daria, et al. “On the Origin and Structure of Haplotype Blocks.” <i>Molecular Ecology</i>, vol. 32, no. 6, Wiley, 2023, pp. 1441–57, doi:<a href=\"https://doi.org/10.1111/mec.16793\">10.1111/mec.16793</a>."},"oa":1,"title":"On the origin and structure of haplotype blocks","page":"1441-1457","date_published":"2023-03-01T00:00:00Z","has_accepted_license":"1","intvolume":"        32","pmid":1,"publication":"Molecular Ecology","acknowledgement":"We thank the Barton group for useful discussion and feedback during the writing of this article. Comments from Roger Butlin, Molly Schumer's Group, the tskit development team, editors and three reviewers greatly improved the manuscript. Funding was provided by SCAS (Natural Sciences Programme, Knut and Alice Wallenberg Foundation), an FWF Wittgenstein grant (PT1001Z211), an FWF standalone grant (grant P 32166), and an ERC Advanced Grant. YFC was supported by the Max Planck Society and an ERC Proof of Concept Grant #101069216 (HAPLOTAGGING).","day":"01","volume":32,"tmp":{"short":"CC BY (4.0)","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","image":"/images/cc_by.png","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode"},"article_processing_charge":"Yes (via OA deal)","file_date_updated":"2023-08-16T08:15:41Z","doi":"10.1111/mec.16793"},{"volume":"150-151","acknowledgement":"This work received funding from the ERC under the European Union’s Horizon 2020 research and innovation programme (grant agreement No. 851288 to E.H.).\r\nB. C-M wants to acknowledge the support of the field of excellence Complexity of Life, in Basic Research and Innovation of the University of Graz.","publication":"Seminars in Cell & Developmental Biology","day":"02","pmid":1,"has_accepted_license":"1","date_published":"2023-12-02T00:00:00Z","doi":"10.1016/j.semcdb.2022.11.005","file_date_updated":"2024-01-08T10:16:04Z","ec_funded":1,"article_processing_charge":"Yes (via OA deal)","tmp":{"short":"CC BY (4.0)","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","image":"/images/cc_by.png","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode"},"oa":1,"citation":{"apa":"Corominas-Murtra, B., &#38; Hannezo, E. B. (2023). Modelling the dynamics of mammalian gut homeostasis. <i>Seminars in Cell &#38; Developmental Biology</i>. Elsevier. <a href=\"https://doi.org/10.1016/j.semcdb.2022.11.005\">https://doi.org/10.1016/j.semcdb.2022.11.005</a>","chicago":"Corominas-Murtra, Bernat, and Edouard B Hannezo. “Modelling the Dynamics of Mammalian Gut Homeostasis.” <i>Seminars in Cell &#38; Developmental Biology</i>. Elsevier, 2023. <a href=\"https://doi.org/10.1016/j.semcdb.2022.11.005\">https://doi.org/10.1016/j.semcdb.2022.11.005</a>.","mla":"Corominas-Murtra, Bernat, and Edouard B. Hannezo. “Modelling the Dynamics of Mammalian Gut Homeostasis.” <i>Seminars in Cell &#38; Developmental Biology</i>, vol. 150–151, Elsevier, 2023, pp. 58–65, doi:<a href=\"https://doi.org/10.1016/j.semcdb.2022.11.005\">10.1016/j.semcdb.2022.11.005</a>.","ama":"Corominas-Murtra B, Hannezo EB. Modelling the dynamics of mammalian gut homeostasis. <i>Seminars in Cell &#38; Developmental Biology</i>. 2023;150-151:58-65. doi:<a href=\"https://doi.org/10.1016/j.semcdb.2022.11.005\">10.1016/j.semcdb.2022.11.005</a>","ieee":"B. Corominas-Murtra and E. B. Hannezo, “Modelling the dynamics of mammalian gut homeostasis,” <i>Seminars in Cell &#38; Developmental Biology</i>, vol. 150–151. Elsevier, pp. 58–65, 2023.","short":"B. Corominas-Murtra, E.B. Hannezo, Seminars in Cell &#38; Developmental Biology 150–151 (2023) 58–65.","ista":"Corominas-Murtra B, Hannezo EB. 2023. Modelling the dynamics of mammalian gut homeostasis. Seminars in Cell &#38; Developmental Biology. 150–151, 58–65."},"date_created":"2023-01-12T12:09:47Z","quality_controlled":"1","page":"58-65","title":"Modelling the dynamics of mammalian gut homeostasis","date_updated":"2024-01-16T13:22:32Z","language":[{"iso":"eng"}],"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","abstract":[{"text":"Homeostatic balance in the intestinal epithelium relies on a fast cellular turnover, which is coordinated by an intricate interplay between biochemical signalling, mechanical forces and organ geometry. We review recent modelling approaches that have been developed to understand different facets of this remarkable homeostatic equilibrium. Existing models offer different, albeit complementary, perspectives on the problem. First, biomechanical models aim to explain the local and global mechanical stresses driving cell renewal as well as tissue shape maintenance. Second, compartmental models provide insights into the conditions necessary to keep a constant flow of cells with well-defined ratios of cell types, and how perturbations can lead to an unbalance of relative compartment sizes. A third family of models address, at the cellular level, the nature and regulation of stem fate choices that are necessary to fuel cellular turnover. We also review how these different approaches are starting to be integrated together across scales, to provide quantitative predictions and new conceptual frameworks to think about the dynamics of cell renewal in complex tissues.","lang":"eng"}],"keyword":["Cell Biology","Developmental Biology"],"scopus_import":"1","author":[{"id":"43BE2298-F248-11E8-B48F-1D18A9856A87","first_name":"Bernat","orcid":"0000-0001-9806-5643","last_name":"Corominas-Murtra","full_name":"Corominas-Murtra, Bernat"},{"first_name":"Edouard B","id":"3A9DB764-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0001-6005-1561","full_name":"Hannezo, Edouard B","last_name":"Hannezo"}],"status":"public","publisher":"Elsevier","type":"journal_article","oa_version":"Published Version","ddc":["570"],"file":[{"file_id":"14741","creator":"dernst","relation":"main_file","file_name":"2023_SeminarsCellDevBiology_CorominasMurtra.pdf","file_size":1343750,"success":1,"checksum":"c619887cf130f4649bf3035417186004","date_created":"2024-01-08T10:16:04Z","access_level":"open_access","content_type":"application/pdf","date_updated":"2024-01-08T10:16:04Z"}],"_id":"12162","external_id":{"pmid":["36470715"],"isi":["001053522200001"]},"publication_status":"published","isi":1,"publication_identifier":{"issn":["1084-9521"]},"year":"2023","month":"12","project":[{"grant_number":"851288","_id":"05943252-7A3F-11EA-A408-12923DDC885E","name":"Design Principles of Branching Morphogenesis","call_identifier":"H2020"}],"department":[{"_id":"EdHa"}],"article_type":"review"},{"file_date_updated":"2023-08-16T08:31:04Z","doi":"10.1002/1873-3468.14540","tmp":{"image":"/images/cc_by_nc_nd.png","name":"Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)","legal_code_url":"https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode","short":"CC BY-NC-ND (4.0)"},"article_processing_charge":"Yes (via OA deal)","pmid":1,"day":"01","publication":"FEBS Letters","acknowledgement":"The authors acknowledge support from IST Austria and helpful comments from the anonymous reviewers that helped to improve this manuscript. We apologize to the authors of primary literature and outstanding research not cited here due to space restraints.","volume":597,"date_published":"2023-03-01T00:00:00Z","intvolume":"       597","has_accepted_license":"1","page":"762-777","title":"In vitro reconstitution of small GTPase regulation","oa":1,"quality_controlled":"1","citation":{"ama":"Loose M, Auer A, Brognara G, Budiman HR, Kowalski LM, Matijevic I. In vitro reconstitution of small GTPase regulation. <i>FEBS Letters</i>. 2023;597(6):762-777. doi:<a href=\"https://doi.org/10.1002/1873-3468.14540\">10.1002/1873-3468.14540</a>","short":"M. Loose, A. Auer, G. Brognara, H.R. Budiman, L.M. Kowalski, I. Matijevic, FEBS Letters 597 (2023) 762–777.","ieee":"M. Loose, A. Auer, G. Brognara, H. R. Budiman, L. M. Kowalski, and I. Matijevic, “In vitro reconstitution of small GTPase regulation,” <i>FEBS Letters</i>, vol. 597, no. 6. Wiley, pp. 762–777, 2023.","ista":"Loose M, Auer A, Brognara G, Budiman HR, Kowalski LM, Matijevic I. 2023. In vitro reconstitution of small GTPase regulation. FEBS Letters. 597(6), 762–777.","mla":"Loose, Martin, et al. “In Vitro Reconstitution of Small GTPase Regulation.” <i>FEBS Letters</i>, vol. 597, no. 6, Wiley, 2023, pp. 762–77, doi:<a href=\"https://doi.org/10.1002/1873-3468.14540\">10.1002/1873-3468.14540</a>.","apa":"Loose, M., Auer, A., Brognara, G., Budiman, H. R., Kowalski, L. M., &#38; Matijevic, I. (2023). In vitro reconstitution of small GTPase regulation. <i>FEBS Letters</i>. Wiley. <a href=\"https://doi.org/10.1002/1873-3468.14540\">https://doi.org/10.1002/1873-3468.14540</a>","chicago":"Loose, Martin, Albert Auer, Gabriel Brognara, Hanifatul R Budiman, Lukasz M Kowalski, and Ivana Matijevic. “In Vitro Reconstitution of Small GTPase Regulation.” <i>FEBS Letters</i>. Wiley, 2023. <a href=\"https://doi.org/10.1002/1873-3468.14540\">https://doi.org/10.1002/1873-3468.14540</a>."},"date_created":"2023-01-12T12:09:58Z","status":"public","author":[{"id":"462D4284-F248-11E8-B48F-1D18A9856A87","first_name":"Martin","last_name":"Loose","full_name":"Loose, Martin","orcid":"0000-0001-7309-9724"},{"first_name":"Albert","id":"3018E8C2-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-3580-2906","last_name":"Auer","full_name":"Auer, Albert"},{"id":"D96FFDA0-A884-11E9-9968-DC26E6697425","first_name":"Gabriel","last_name":"Brognara","full_name":"Brognara, Gabriel"},{"id":"55380f95-15b2-11ec-abd3-aff8e230696b","first_name":"Hanifatul R","full_name":"Budiman, Hanifatul R","last_name":"Budiman"},{"full_name":"Kowalski, Lukasz M","last_name":"Kowalski","first_name":"Lukasz M","id":"e3a512e2-4bbe-11eb-a68a-e3857a7844c2"},{"id":"83c17ce3-15b2-11ec-abd3-f486545870bd","first_name":"Ivana","full_name":"Matijevic, Ivana","last_name":"Matijevic"}],"language":[{"iso":"eng"}],"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","date_updated":"2023-08-16T08:32:29Z","scopus_import":"1","keyword":["Cell Biology","Genetics","Molecular Biology","Biochemistry","Structural Biology","Biophysics"],"abstract":[{"lang":"eng","text":"Small GTPases play essential roles in the organization of eukaryotic cells. In recent years, it has become clear that their intracellular functions result from intricate biochemical networks of the GTPase and their regulators that dynamically bind to a membrane surface. Due to the inherent complexities of their interactions, however, revealing the underlying mechanisms of action is often difficult to achieve from in vivo studies. This review summarizes in vitro reconstitution approaches developed to obtain a better mechanistic understanding of how small GTPase activities are regulated in space and time."}],"month":"03","year":"2023","publication_identifier":{"issn":["0014-5793"],"eissn":["1873-3468"]},"isi":1,"article_type":"review","department":[{"_id":"MaLo"}],"publisher":"Wiley","publication_status":"published","external_id":{"pmid":["36448231"],"isi":["000891573000001"]},"issue":"6","_id":"12163","file":[{"checksum":"7492244d3f9c5faa1347ef03f6e5bc84","file_size":3148143,"success":1,"date_created":"2023-08-16T08:31:04Z","content_type":"application/pdf","access_level":"open_access","date_updated":"2023-08-16T08:31:04Z","creator":"dernst","file_id":"14063","relation":"main_file","file_name":"2023_FEBSLetters_Loose.pdf"}],"type":"journal_article","oa_version":"Published Version","ddc":["570"]},{"intvolume":"        36","date_published":"2023-03-01T00:00:00Z","day":"01","acknowledgement":"A preliminary version of this work appeared in DISC’19. Mirza Ahad Baig, Alessia Milani and Corentin Travers are supported by ANR projects Descartes and FREDDA. Mirza Ahad Baig is supported by UMI Relax. Danny Hendler is supported by the Israel Science Foundation (Grants 380/18 and 1425/22).","publication":"Distributed Computing","volume":36,"article_processing_charge":"No","doi":"10.1007/s00446-022-00439-5","date_created":"2023-01-12T12:10:08Z","citation":{"mla":"Baig, Mirza Ahad, et al. “Long-Lived Counters with Polylogarithmic Amortized Step Complexity.” <i>Distributed Computing</i>, vol. 36, Springer Nature, 2023, pp. 29–43, doi:<a href=\"https://doi.org/10.1007/s00446-022-00439-5\">10.1007/s00446-022-00439-5</a>.","apa":"Baig, M. A., Hendler, D., Milani, A., &#38; Travers, C. (2023). Long-lived counters with polylogarithmic amortized step complexity. <i>Distributed Computing</i>. Springer Nature. <a href=\"https://doi.org/10.1007/s00446-022-00439-5\">https://doi.org/10.1007/s00446-022-00439-5</a>","chicago":"Baig, Mirza Ahad, Danny Hendler, Alessia Milani, and Corentin Travers. “Long-Lived Counters with Polylogarithmic Amortized Step Complexity.” <i>Distributed Computing</i>. Springer Nature, 2023. <a href=\"https://doi.org/10.1007/s00446-022-00439-5\">https://doi.org/10.1007/s00446-022-00439-5</a>.","ama":"Baig MA, Hendler D, Milani A, Travers C. Long-lived counters with polylogarithmic amortized step complexity. <i>Distributed Computing</i>. 2023;36:29-43. doi:<a href=\"https://doi.org/10.1007/s00446-022-00439-5\">10.1007/s00446-022-00439-5</a>","short":"M.A. Baig, D. Hendler, A. Milani, C. Travers, Distributed Computing 36 (2023) 29–43.","ista":"Baig MA, Hendler D, Milani A, Travers C. 2023. Long-lived counters with polylogarithmic amortized step complexity. Distributed Computing. 36, 29–43.","ieee":"M. A. Baig, D. Hendler, A. Milani, and C. Travers, “Long-lived counters with polylogarithmic amortized step complexity,” <i>Distributed Computing</i>, vol. 36. Springer Nature, pp. 29–43, 2023."},"quality_controlled":"1","oa":1,"title":"Long-lived counters with polylogarithmic amortized step complexity","page":"29-43","main_file_link":[{"url":"https://drops.dagstuhl.de/opus/volltexte/2019/11310/","open_access":"1"}],"keyword":["Computational Theory and Mathematics","Computer Networks and Communications","Hardware and Architecture","Theoretical Computer Science"],"abstract":[{"text":"A shared-memory counter is a widely-used and well-studied concurrent object. It supports two operations: An Inc operation that increases its value by 1 and a Read operation that returns its current value. In Jayanti et al (SIAM J Comput, 30(2), 2000), Jayanti, Tan and Toueg proved a linear lower bound on the worst-case step complexity of obstruction-free implementations, from read-write registers, of a large class of shared objects that includes counters. The lower bound leaves open the question of finding counter implementations with sub-linear amortized step complexity. In this work, we address this gap. We show that n-process, wait-free and linearizable counters can be implemented from read-write registers with O(log2n) amortized step complexity. This is the first counter algorithm from read-write registers that provides sub-linear amortized step complexity in executions of arbitrary length. Since a logarithmic lower bound on the amortized step complexity of obstruction-free counter implementations exists, our upper bound is within a logarithmic factor of the optimal. The worst-case step complexity of the construction remains linear, which is optimal. This is obtained thanks to a new max register construction with O(logn) amortized step complexity in executions of arbitrary length in which the value stored in the register does not grow too quickly. We then leverage an existing counter algorithm by Aspnes, Attiya and Censor-Hillel [1] in which we “plug” our max register implementation to show that it remains linearizable while achieving O(log2n) amortized step complexity.","lang":"eng"}],"scopus_import":"1","date_updated":"2023-08-16T08:39:36Z","language":[{"iso":"eng"}],"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","status":"public","author":[{"first_name":"Mirza Ahad","id":"3EDE6DE4-AA5A-11E9-986D-341CE6697425","full_name":"Baig, Mirza Ahad","last_name":"Baig"},{"full_name":"Hendler, Danny","last_name":"Hendler","first_name":"Danny"},{"first_name":"Alessia","last_name":"Milani","full_name":"Milani, Alessia"},{"first_name":"Corentin","last_name":"Travers","full_name":"Travers, Corentin"}],"oa_version":"Preprint","type":"journal_article","external_id":{"isi":["000890138700001"]},"publication_status":"published","_id":"12164","publisher":"Springer Nature","department":[{"_id":"KrPi"}],"article_type":"original","publication_identifier":{"eissn":["1432-0452"],"issn":["0178-2770"]},"isi":1,"year":"2023","month":"03"},{"doi":"10.1038/s42254-022-00539-y","article_processing_charge":"No","volume":5,"publication":"Nature Reviews Physics","day":"01","date_published":"2023-01-01T00:00:00Z","intvolume":"         5","page":"62-72","title":"Directed percolation and the transition to turbulence","quality_controlled":"1","citation":{"ama":"Hof B. Directed percolation and the transition to turbulence. <i>Nature Reviews Physics</i>. 2023;5:62-72. doi:<a href=\"https://doi.org/10.1038/s42254-022-00539-y\">10.1038/s42254-022-00539-y</a>","ieee":"B. Hof, “Directed percolation and the transition to turbulence,” <i>Nature Reviews Physics</i>, vol. 5. Springer Nature, pp. 62–72, 2023.","short":"B. Hof, Nature Reviews Physics 5 (2023) 62–72.","ista":"Hof B. 2023. Directed percolation and the transition to turbulence. Nature Reviews Physics. 5, 62–72.","mla":"Hof, Björn. “Directed Percolation and the Transition to Turbulence.” <i>Nature Reviews Physics</i>, vol. 5, Springer Nature, 2023, pp. 62–72, doi:<a href=\"https://doi.org/10.1038/s42254-022-00539-y\">10.1038/s42254-022-00539-y</a>.","apa":"Hof, B. (2023). Directed percolation and the transition to turbulence. <i>Nature Reviews Physics</i>. Springer Nature. <a href=\"https://doi.org/10.1038/s42254-022-00539-y\">https://doi.org/10.1038/s42254-022-00539-y</a>","chicago":"Hof, Björn. “Directed Percolation and the Transition to Turbulence.” <i>Nature Reviews Physics</i>. Springer Nature, 2023. <a href=\"https://doi.org/10.1038/s42254-022-00539-y\">https://doi.org/10.1038/s42254-022-00539-y</a>."},"date_created":"2023-01-12T12:10:18Z","author":[{"id":"3A374330-F248-11E8-B48F-1D18A9856A87","first_name":"Björn","orcid":"0000-0003-2057-2754","full_name":"Hof, Björn","last_name":"Hof"}],"status":"public","user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","language":[{"iso":"eng"}],"date_updated":"2023-08-01T12:50:48Z","scopus_import":"1","abstract":[{"text":"It may come as a surprise that a phenomenon as ubiquitous and prominent as the transition from laminar to turbulent flow has resisted combined efforts by physicists, engineers and mathematicians, and remained unresolved for almost one and a half centuries. In recent years, various studies have proposed analogies to directed percolation, a well-known universality class in statistical mechanics, which describes a non-equilibrium phase transition from a fluctuating active phase into an absorbing state. It is this unlikely relation between the multiscale, high-dimensional dynamics that signify the transition process in virtually all flows of practical relevance, and the arguably most basic non-equilibrium phase transition, that so far has mainly been the subject of model studies, which I review in this Perspective.","lang":"eng"}],"keyword":["General Physics and Astronomy"],"year":"2023","month":"01","isi":1,"publication_identifier":{"eissn":["2522-5820"]},"article_type":"original","department":[{"_id":"BjHo"}],"publisher":"Springer Nature","_id":"12165","external_id":{"isi":["000890148700002"]},"publication_status":"published","oa_version":"None","type":"journal_article"},{"article_processing_charge":"No","doi":"10.1016/j.matpr.2022.11.037","intvolume":"        78","date_published":"2023-03-20T00:00:00Z","volume":78,"publication":"Materials Today: Proceedings","day":"20","title":"Experimental analysis of Cascade CSTRs with step and pulse inputs","page":"40-47","date_created":"2023-01-12T12:11:26Z","citation":{"ama":"Khatoon B, Kamil S, Babu H, Siraj Alam M. Experimental analysis of Cascade CSTRs with step and pulse inputs. <i>Materials Today: Proceedings</i>. 2023;78(Part 1):40-47. doi:<a href=\"https://doi.org/10.1016/j.matpr.2022.11.037\">10.1016/j.matpr.2022.11.037</a>","ista":"Khatoon B, Kamil S, Babu H, Siraj Alam M. 2023. Experimental analysis of Cascade CSTRs with step and pulse inputs. Materials Today: Proceedings. 78(Part 1), 40–47.","ieee":"B. Khatoon, S. Kamil, H. Babu, and M. Siraj Alam, “Experimental analysis of Cascade CSTRs with step and pulse inputs,” <i>Materials Today: Proceedings</i>, vol. 78, no. Part 1. Elsevier, pp. 40–47, 2023.","short":"B. Khatoon, S. Kamil, H. Babu, M. Siraj Alam, Materials Today: Proceedings 78 (2023) 40–47.","mla":"Khatoon, Bushra, et al. “Experimental Analysis of Cascade CSTRs with Step and Pulse Inputs.” <i>Materials Today: Proceedings</i>, vol. 78, no. Part 1, Elsevier, 2023, pp. 40–47, doi:<a href=\"https://doi.org/10.1016/j.matpr.2022.11.037\">10.1016/j.matpr.2022.11.037</a>.","apa":"Khatoon, B., Kamil, S., Babu, H., &#38; Siraj Alam, M. (2023). Experimental analysis of Cascade CSTRs with step and pulse inputs. <i>Materials Today: Proceedings</i>. Elsevier. <a href=\"https://doi.org/10.1016/j.matpr.2022.11.037\">https://doi.org/10.1016/j.matpr.2022.11.037</a>","chicago":"Khatoon, Bushra, Shoaib Kamil, Hitesh Babu, and M. Siraj Alam. “Experimental Analysis of Cascade CSTRs with Step and Pulse Inputs.” <i>Materials Today: Proceedings</i>. Elsevier, 2023. <a href=\"https://doi.org/10.1016/j.matpr.2022.11.037\">https://doi.org/10.1016/j.matpr.2022.11.037</a>."},"quality_controlled":"1","author":[{"first_name":"Bushra","full_name":"Khatoon, Bushra","last_name":"Khatoon"},{"first_name":"Shoaib","id":"185a19af-dc7d-11ea-9b2f-8eb2201959e9","full_name":"Kamil, Shoaib","last_name":"Kamil"},{"last_name":"Babu","full_name":"Babu, Hitesh","first_name":"Hitesh"},{"first_name":"M.","full_name":"Siraj Alam, M.","last_name":"Siraj Alam"}],"status":"public","abstract":[{"lang":"eng","text":"In industrial reactors and equipment, non-ideality is quite a common phenomenon rather than an exception. These deviations from ideality impact the process's overall efficiency and the effectiveness of the equipment. To recognize the associated non-ideality, one needs to have enough understanding of the formulation of the equations and in-depth knowledge of the residence time distribution (RTD) data of real reactors. In the current work, step input and pulse input were used to create RTD data for Cascade continuous stirred tank reactors (CSTRs). For the aforementioned configuration, experiments were run at various flow rates to validate the developed characteristic equations. To produce RTD data, distilled water was utilized as the flowing fluid, and NaOH was the tracer substance. The ideal behavior of tracer concentration exits age distribution, and cumulative fraction for each setup and each input was plotted and experimental results were compared with perfect behavior. Deviation of concentration exit age distribution and cumulative fractional distribution from ideal behavior is more in pulse input as compared to a step input. For ideal cases, the exit age distribution curve and cumulative fraction curves are independent of the type of input. But a significant difference was observed for the two cases, which may be due to non-measurable fluctuations in volumetric flow rate, non-achievement of instant injection of tracer in case of pulse input, and slight variations in the sampling period. Further, with increasing flow rate, concentration, exit age, and cumulative fractional curves shifted upward, and this behavior matches with the actual case."}],"keyword":["General Medicine"],"scopus_import":"1","date_updated":"2023-08-16T09:08:11Z","language":[{"iso":"eng"}],"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","department":[{"_id":"BjHo"}],"article_type":"original","publication_identifier":{"issn":["2214-7853"]},"month":"03","year":"2023","oa_version":"None","type":"journal_article","issue":"Part 1","_id":"12172","publication_status":"published","publisher":"Elsevier"},{"arxiv":1,"quality_controlled":"1","date_created":"2023-01-15T23:00:52Z","citation":{"short":"C. Boccato, R. Seiringer, Annales Henri Poincare 24 (2023) 1505–1560.","ieee":"C. Boccato and R. Seiringer, “The Bose Gas in a box with Neumann boundary conditions,” <i>Annales Henri Poincare</i>, vol. 24. Springer Nature, pp. 1505–1560, 2023.","ista":"Boccato C, Seiringer R. 2023. The Bose Gas in a box with Neumann boundary conditions. Annales Henri Poincare. 24, 1505–1560.","ama":"Boccato C, Seiringer R. The Bose Gas in a box with Neumann boundary conditions. <i>Annales Henri Poincare</i>. 2023;24:1505-1560. doi:<a href=\"https://doi.org/10.1007/s00023-022-01252-3\">10.1007/s00023-022-01252-3</a>","mla":"Boccato, Chiara, and Robert Seiringer. “The Bose Gas in a Box with Neumann Boundary Conditions.” <i>Annales Henri Poincare</i>, vol. 24, Springer Nature, 2023, pp. 1505–60, doi:<a href=\"https://doi.org/10.1007/s00023-022-01252-3\">10.1007/s00023-022-01252-3</a>.","chicago":"Boccato, Chiara, and Robert Seiringer. “The Bose Gas in a Box with Neumann Boundary Conditions.” <i>Annales Henri Poincare</i>. Springer Nature, 2023. <a href=\"https://doi.org/10.1007/s00023-022-01252-3\">https://doi.org/10.1007/s00023-022-01252-3</a>.","apa":"Boccato, C., &#38; Seiringer, R. (2023). The Bose Gas in a box with Neumann boundary conditions. <i>Annales Henri Poincare</i>. Springer Nature. <a href=\"https://doi.org/10.1007/s00023-022-01252-3\">https://doi.org/10.1007/s00023-022-01252-3</a>"},"oa":1,"title":"The Bose Gas in a box with Neumann boundary conditions","page":"1505-1560","date_published":"2023-05-01T00:00:00Z","intvolume":"        24","publication":"Annales Henri Poincare","acknowledgement":"Funding from the European Union’s Horizon 2020 research and innovation programme under the ERC grant agreement No 694227 is gratefully acknowledged.","day":"01","volume":24,"ec_funded":1,"article_processing_charge":"No","doi":"10.1007/s00023-022-01252-3","external_id":{"arxiv":["2205.15284"],"isi":["000910751800002"]},"publication_status":"published","_id":"12183","oa_version":"Preprint","type":"journal_article","publisher":"Springer Nature","article_type":"original","department":[{"_id":"RoSe"}],"project":[{"name":"Analysis of quantum many-body systems","call_identifier":"H2020","_id":"25C6DC12-B435-11E9-9278-68D0E5697425","grant_number":"694227"}],"month":"05","year":"2023","publication_identifier":{"issn":["1424-0637"]},"isi":1,"scopus_import":"1","main_file_link":[{"open_access":"1","url":"https://doi.org/10.48550/arXiv.2205.15284"}],"abstract":[{"text":"We consider a gas of n bosonic particles confined in a box [−ℓ/2,ℓ/2]3 with Neumann boundary conditions. We prove Bose–Einstein condensation in the Gross–Pitaevskii regime, with an optimal bound on the condensate depletion. Moreover, our lower bound for the ground state energy in a small box [−ℓ/2,ℓ/2]3 implies (via Neumann bracketing) a lower bound for the ground state energy of N bosons in a large box [−L/2,L/2]3 with density ρ=N/L3 in the thermodynamic limit.","lang":"eng"}],"language":[{"iso":"eng"}],"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","date_updated":"2023-08-16T11:34:03Z","status":"public","author":[{"last_name":"Boccato","full_name":"Boccato, Chiara","id":"342E7E22-F248-11E8-B48F-1D18A9856A87","first_name":"Chiara"},{"last_name":"Seiringer","full_name":"Seiringer, Robert","orcid":"0000-0002-6781-0521","id":"4AFD0470-F248-11E8-B48F-1D18A9856A87","first_name":"Robert"}]},{"page":"35-45","title":"Impact of BRCA mutation status on tumor dissemination pattern, surgical outcome and patient survival in primary and recurrent high-grade serous ovarian cancer: A multicenter retrospective study by the Ovarian Cancer Therapy-Innovative Models Prolong Survival (OCTIPS) consortium","oa":1,"quality_controlled":"1","citation":{"mla":"Glajzer, Jacek, et al. “Impact of BRCA Mutation Status on Tumor Dissemination Pattern, Surgical Outcome and Patient Survival in Primary and Recurrent High-Grade Serous Ovarian Cancer: A Multicenter Retrospective Study by the Ovarian Cancer Therapy-Innovative Models Prolong Survival (OCTIPS) Consortium.” <i>Annals of Surgical Oncology</i>, vol. 30, Springer Nature, 2023, pp. 35–45, doi:<a href=\"https://doi.org/10.1245/s10434-022-12459-3\">10.1245/s10434-022-12459-3</a>.","chicago":"Glajzer, Jacek, Dan Cacsire Castillo-Tong, Rolf Richter, Ignace Vergote, Hagen Kulbe, Adriaan Vanderstichele, Ilary Ruscito, et al. “Impact of BRCA Mutation Status on Tumor Dissemination Pattern, Surgical Outcome and Patient Survival in Primary and Recurrent High-Grade Serous Ovarian Cancer: A Multicenter Retrospective Study by the Ovarian Cancer Therapy-Innovative Models Prolong Survival (OCTIPS) Consortium.” <i>Annals of Surgical Oncology</i>. Springer Nature, 2023. <a href=\"https://doi.org/10.1245/s10434-022-12459-3\">https://doi.org/10.1245/s10434-022-12459-3</a>.","apa":"Glajzer, J., Castillo-Tong, D. C., Richter, R., Vergote, I., Kulbe, H., Vanderstichele, A., … Braicu, E. I. (2023). Impact of BRCA mutation status on tumor dissemination pattern, surgical outcome and patient survival in primary and recurrent high-grade serous ovarian cancer: A multicenter retrospective study by the Ovarian Cancer Therapy-Innovative Models Prolong Survival (OCTIPS) consortium. <i>Annals of Surgical Oncology</i>. Springer Nature. <a href=\"https://doi.org/10.1245/s10434-022-12459-3\">https://doi.org/10.1245/s10434-022-12459-3</a>","short":"J. Glajzer, D.C. Castillo-Tong, R. Richter, I. Vergote, H. Kulbe, A. Vanderstichele, I. Ruscito, F. Trillsch, A. Mustea, C. Kreuzinger, C. Gourley, H. Gabra, E.T. Taube, O. Dorigo, D. Horst, C. Keunecke, J. Baum, T. Angelotti, J. Sehouli, E.I. Braicu, Annals of Surgical Oncology 30 (2023) 35–45.","ista":"Glajzer J, Castillo-Tong DC, Richter R, Vergote I, Kulbe H, Vanderstichele A, Ruscito I, Trillsch F, Mustea A, Kreuzinger C, Gourley C, Gabra H, Taube ET, Dorigo O, Horst D, Keunecke C, Baum J, Angelotti T, Sehouli J, Braicu EI. 2023. Impact of BRCA mutation status on tumor dissemination pattern, surgical outcome and patient survival in primary and recurrent high-grade serous ovarian cancer: A multicenter retrospective study by the Ovarian Cancer Therapy-Innovative Models Prolong Survival (OCTIPS) consortium. Annals of Surgical Oncology. 30, 35–45.","ieee":"J. Glajzer <i>et al.</i>, “Impact of BRCA mutation status on tumor dissemination pattern, surgical outcome and patient survival in primary and recurrent high-grade serous ovarian cancer: A multicenter retrospective study by the Ovarian Cancer Therapy-Innovative Models Prolong Survival (OCTIPS) consortium,” <i>Annals of Surgical Oncology</i>, vol. 30. Springer Nature, pp. 35–45, 2023.","ama":"Glajzer J, Castillo-Tong DC, Richter R, et al. Impact of BRCA mutation status on tumor dissemination pattern, surgical outcome and patient survival in primary and recurrent high-grade serous ovarian cancer: A multicenter retrospective study by the Ovarian Cancer Therapy-Innovative Models Prolong Survival (OCTIPS) consortium. <i>Annals of Surgical Oncology</i>. 2023;30:35-45. doi:<a href=\"https://doi.org/10.1245/s10434-022-12459-3\">10.1245/s10434-022-12459-3</a>"},"date_created":"2023-01-16T09:44:36Z","file_date_updated":"2023-02-02T13:01:20Z","doi":"10.1245/s10434-022-12459-3","tmp":{"short":"CC BY (4.0)","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","image":"/images/cc_by.png","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode"},"article_processing_charge":"No","publication":"Annals of Surgical Oncology","acknowledgement":"E.I.B. is a Feodor Lynen fellow of the Humboldt Foundation and a participant of the Charité Clinical Scientist Program funded by the Charité Universitätsmedizin Berlin and the Berlin Institute of Health. This work was supported by European Commission’s Seventh Framework Programme under grant agreement no. 279113 (OCTIPS; www.octips.eu).\r\nOpen Access funding enabled and organized by Projekt DEAL.","day":"01","volume":30,"date_published":"2023-01-01T00:00:00Z","intvolume":"        30","has_accepted_license":"1","month":"01","year":"2023","publication_identifier":{"eissn":["1534-4681"],"issn":["1068-9265"]},"isi":1,"article_type":"original","department":[{"_id":"JoDa"}],"publisher":"Springer Nature","external_id":{"isi":["000852125500006"]},"publication_status":"published","_id":"12205","type":"journal_article","file":[{"content_type":"application/pdf","access_level":"open_access","date_updated":"2023-02-02T13:01:20Z","file_size":365865,"success":1,"checksum":"36a1200e1011f4b2155a8041d0308f34","date_created":"2023-02-02T13:01:20Z","file_name":"2023_AnnalsSurgicalOncology_Glajzer.pdf","creator":"dernst","file_id":"12490","relation":"main_file"}],"ddc":["610"],"oa_version":"Published Version","status":"public","author":[{"first_name":"Jacek","last_name":"Glajzer","full_name":"Glajzer, Jacek"},{"full_name":"Castillo-Tong, Dan Cacsire","last_name":"Castillo-Tong","first_name":"Dan Cacsire"},{"full_name":"Richter, Rolf","last_name":"Richter","first_name":"Rolf"},{"full_name":"Vergote, Ignace","last_name":"Vergote","first_name":"Ignace"},{"last_name":"Kulbe","full_name":"Kulbe, Hagen","first_name":"Hagen"},{"first_name":"Adriaan","last_name":"Vanderstichele","full_name":"Vanderstichele, Adriaan"},{"full_name":"Ruscito, Ilary","last_name":"Ruscito","first_name":"Ilary"},{"first_name":"Fabian","full_name":"Trillsch, Fabian","last_name":"Trillsch"},{"first_name":"Alexander","last_name":"Mustea","full_name":"Mustea, Alexander"},{"last_name":"Kreuzinger","full_name":"Kreuzinger, Caroline","id":"382077BA-F248-11E8-B48F-1D18A9856A87","first_name":"Caroline"},{"first_name":"Charlie","full_name":"Gourley, Charlie","last_name":"Gourley"},{"full_name":"Gabra, Hani","last_name":"Gabra","first_name":"Hani"},{"full_name":"Taube, Eliane T.","last_name":"Taube","first_name":"Eliane T."},{"first_name":"Oliver","full_name":"Dorigo, Oliver","last_name":"Dorigo"},{"first_name":"David","full_name":"Horst, David","last_name":"Horst"},{"first_name":"Carlotta","full_name":"Keunecke, Carlotta","last_name":"Keunecke"},{"full_name":"Baum, Joanna","last_name":"Baum","first_name":"Joanna"},{"full_name":"Angelotti, Timothy","last_name":"Angelotti","first_name":"Timothy"},{"first_name":"Jalid","full_name":"Sehouli, Jalid","last_name":"Sehouli"},{"full_name":"Braicu, Elena Ioana","last_name":"Braicu","first_name":"Elena Ioana"}],"language":[{"iso":"eng"}],"user_id":"c635000d-4b10-11ee-a964-aac5a93f6ac1","date_updated":"2023-09-05T15:18:37Z","scopus_import":"1","related_material":{"record":[{"id":"12115","relation":"other","status":"public"}]},"keyword":["Oncology","Surgery"],"abstract":[{"lang":"eng","text":"Background: This study seeks to evaluate the impact of breast cancer (BRCA) gene status on tumor dissemination pattern, surgical outcome and survival in a multicenter cohort of paired primary ovarian cancer (pOC) and recurrent ovarian cancer (rOC).\r\n\r\nPatients and Methods: Medical records and follow-up data from 190 patients were gathered retrospectively. All patients had surgery at pOC and at least one further rOC surgery at four European high-volume centers. Patients were divided into one cohort with confirmed mutation for BRCA1 and/or BRCA2 (BRCAmut) and a second cohort with BRCA wild type or unknown (BRCAwt). Patterns of tumor presentation, surgical outcome and survival data were analyzed between the two groups.\r\n\r\nResults: Patients with BRCAmut disease were on average 4 years younger and had significantly more tumor involvement upon diagnosis. Patients with BRCAmut disease showed higher debulking rates at all stages. Multivariate analysis showed that only patient age had significant predictive value for complete tumor resection in pOC. At rOC, however, only BRCAmut status significantly correlated with optimal debulking. Patients with BRCAmut disease showed significantly prolonged overall survival (OS) by 24.3 months. Progression-free survival (PFS) was prolonged in the BRCAmut group at all stages as well, reaching statistical significance during recurrence.\r\n\r\nConclusions: Patients with BRCAmut disease showed a more aggressive course of disease with earlier onset and more extensive tumor dissemination at pOC. However, surgical outcome and OS were significantly better in patients with BRCAmut disease compared with patients with BRCAwt disease. We therefore propose to consider BRCAmut status in regard to patient selection for cytoreductive surgery, especially in rOC."}]},{"abstract":[{"text":"We present criteria for establishing a triangulation of a manifold. Given a manifold M, a simplicial complex A, and a map H from the underlying space of A to M, our criteria are presented in local coordinate charts for M, and ensure that H is a homeomorphism. These criteria do not require a differentiable structure, or even an explicit metric on M. No Delaunay property of A is assumed. The result provides a triangulation guarantee for algorithms that construct a simplicial complex by working in local coordinate patches. Because the criteria are easily verified in such a setting, they are expected to be of general use.","lang":"eng"}],"keyword":["Computational Theory and Mathematics","Discrete Mathematics and Combinatorics","Geometry and Topology","Theoretical Computer Science"],"scopus_import":"1","date_updated":"2023-08-01T12:47:32Z","language":[{"iso":"eng"}],"user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","author":[{"full_name":"Boissonnat, Jean-Daniel","last_name":"Boissonnat","first_name":"Jean-Daniel"},{"last_name":"Dyer","full_name":"Dyer, Ramsay","first_name":"Ramsay"},{"full_name":"Ghosh, Arijit","last_name":"Ghosh","first_name":"Arijit"},{"id":"307CFBC8-F248-11E8-B48F-1D18A9856A87","first_name":"Mathijs","orcid":"0000-0002-7472-2220","last_name":"Wintraecken","full_name":"Wintraecken, Mathijs"}],"status":"public","ddc":["510"],"type":"journal_article","oa_version":"Published Version","file":[{"file_name":"2023_DiscreteCompGeometry_Boissonnat.pdf","file_id":"12488","creator":"dernst","relation":"main_file","access_level":"open_access","content_type":"application/pdf","date_updated":"2023-02-02T11:01:10Z","checksum":"46352e0ee71e460848f88685ca852681","file_size":582850,"success":1,"date_created":"2023-02-02T11:01:10Z"}],"_id":"12287","external_id":{"isi":["000862193600001"]},"publication_status":"published","publisher":"Springer Nature","department":[{"_id":"HeEd"}],"article_type":"original","isi":1,"publication_identifier":{"eissn":["1432-0444"],"issn":["0179-5376"]},"month":"01","year":"2023","project":[{"grant_number":"754411","_id":"260C2330-B435-11E9-9278-68D0E5697425","name":"ISTplus - Postdoctoral Fellowships","call_identifier":"H2020"},{"grant_number":"M03073","name":"Learning and triangulating manifolds via collapses","_id":"fc390959-9c52-11eb-aca3-afa58bd282b2"}],"has_accepted_license":"1","intvolume":"        69","date_published":"2023-01-01T00:00:00Z","volume":69,"acknowledgement":"This work has been funded by the European Research Council under the European Union’s ERC Grant Agreement number 339025 GUDHI (Algorithmic Foundations of Geometric Understanding in Higher Dimensions). Arijit Ghosh is supported by Ramanujan Fellowship (No. SB/S2/RJN-064/2015). Part of this work was done when Arijit Ghosh was a Researcher at Max-Planck-Institute for Informatics, Germany, supported by the IndoGerman Max Planck Center for Computer Science (IMPECS). Mathijs Wintraecken also received funding from the European Union’s Horizon 2020 research and innovation programme under the Marie Skłodowska-Curie grant agreement No. 754411 and the Austrian Science Fund (FWF): M-3073. A part of the results described in this paper were presented at SoCG 2018 and in [3]. \r\nOpen access funding provided by the Austrian Science Fund (FWF).","day":"01","publication":"Discrete & Computational Geometry","ec_funded":1,"article_processing_charge":"No","tmp":{"short":"CC BY (4.0)","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","image":"/images/cc_by.png","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode"},"doi":"10.1007/s00454-022-00431-7","file_date_updated":"2023-02-02T11:01:10Z","citation":{"mla":"Boissonnat, Jean-Daniel, et al. “Local Criteria for Triangulating General Manifolds.” <i>Discrete &#38; Computational Geometry</i>, vol. 69, Springer Nature, 2023, pp. 156–91, doi:<a href=\"https://doi.org/10.1007/s00454-022-00431-7\">10.1007/s00454-022-00431-7</a>.","chicago":"Boissonnat, Jean-Daniel, Ramsay Dyer, Arijit Ghosh, and Mathijs Wintraecken. “Local Criteria for Triangulating General Manifolds.” <i>Discrete &#38; Computational Geometry</i>. Springer Nature, 2023. <a href=\"https://doi.org/10.1007/s00454-022-00431-7\">https://doi.org/10.1007/s00454-022-00431-7</a>.","apa":"Boissonnat, J.-D., Dyer, R., Ghosh, A., &#38; Wintraecken, M. (2023). Local criteria for triangulating general manifolds. <i>Discrete &#38; Computational Geometry</i>. Springer Nature. <a href=\"https://doi.org/10.1007/s00454-022-00431-7\">https://doi.org/10.1007/s00454-022-00431-7</a>","ista":"Boissonnat J-D, Dyer R, Ghosh A, Wintraecken M. 2023. Local criteria for triangulating general manifolds. Discrete &#38; Computational Geometry. 69, 156–191.","short":"J.-D. Boissonnat, R. Dyer, A. Ghosh, M. Wintraecken, Discrete &#38; Computational Geometry 69 (2023) 156–191.","ieee":"J.-D. Boissonnat, R. Dyer, A. Ghosh, and M. Wintraecken, “Local criteria for triangulating general manifolds,” <i>Discrete &#38; Computational Geometry</i>, vol. 69. Springer Nature, pp. 156–191, 2023.","ama":"Boissonnat J-D, Dyer R, Ghosh A, Wintraecken M. Local criteria for triangulating general manifolds. <i>Discrete &#38; Computational Geometry</i>. 2023;69:156-191. doi:<a href=\"https://doi.org/10.1007/s00454-022-00431-7\">10.1007/s00454-022-00431-7</a>"},"date_created":"2023-01-16T10:04:06Z","quality_controlled":"1","oa":1,"title":"Local criteria for triangulating general manifolds","page":"156-191"},{"title":"Some effectivity results for primitive divisors of elliptic divisibility  sequences","page":"331-351","date_created":"2023-01-16T11:46:19Z","citation":{"ama":"Verzobio M. Some effectivity results for primitive divisors of elliptic divisibility  sequences. <i>Pacific Journal of Mathematics</i>. 2023;325(2):331-351. doi:<a href=\"https://doi.org/10.2140/pjm.2023.325.331\">10.2140/pjm.2023.325.331</a>","short":"M. Verzobio, Pacific Journal of Mathematics 325 (2023) 331–351.","ista":"Verzobio M. 2023. Some effectivity results for primitive divisors of elliptic divisibility  sequences. Pacific Journal of Mathematics. 325(2), 331–351.","ieee":"M. Verzobio, “Some effectivity results for primitive divisors of elliptic divisibility  sequences,” <i>Pacific Journal of Mathematics</i>, vol. 325, no. 2. Mathematical Sciences Publishers, pp. 331–351, 2023.","apa":"Verzobio, M. (2023). Some effectivity results for primitive divisors of elliptic divisibility  sequences. <i>Pacific Journal of Mathematics</i>. Mathematical Sciences Publishers. <a href=\"https://doi.org/10.2140/pjm.2023.325.331\">https://doi.org/10.2140/pjm.2023.325.331</a>","chicago":"Verzobio, Matteo. “Some Effectivity Results for Primitive Divisors of Elliptic Divisibility  Sequences.” <i>Pacific Journal of Mathematics</i>. Mathematical Sciences Publishers, 2023. <a href=\"https://doi.org/10.2140/pjm.2023.325.331\">https://doi.org/10.2140/pjm.2023.325.331</a>.","mla":"Verzobio, Matteo. “Some Effectivity Results for Primitive Divisors of Elliptic Divisibility  Sequences.” <i>Pacific Journal of Mathematics</i>, vol. 325, no. 2, Mathematical Sciences Publishers, 2023, pp. 331–51, doi:<a href=\"https://doi.org/10.2140/pjm.2023.325.331\">10.2140/pjm.2023.325.331</a>."},"quality_controlled":"1","arxiv":1,"oa":1,"tmp":{"short":"CC BY (4.0)","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","image":"/images/cc_by.png","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode"},"ec_funded":1,"article_processing_charge":"Yes (in subscription journal)","doi":"10.2140/pjm.2023.325.331","file_date_updated":"2023-11-13T09:50:41Z","intvolume":"       325","has_accepted_license":"1","date_published":"2023-11-03T00:00:00Z","publication":"Pacific Journal of Mathematics","acknowledgement":"This paper is part of the author’s PhD thesis at Università of Pisa. Moreover, this\r\nproject has received funding from the European Union’s Horizon 2020 research\r\nand innovation programme under the Marie Skłodowska-Curie Grant Agreement\r\nNo. 101034413. I thank the referee for many helpful comments.","day":"03","volume":325,"department":[{"_id":"TiBr"}],"article_type":"original","publication_identifier":{"eissn":["0030-8730"]},"isi":1,"project":[{"grant_number":"101034413","call_identifier":"H2020","name":"IST-BRIDGE: International postdoctoral program","_id":"fc2ed2f7-9c52-11eb-aca3-c01059dda49c"}],"month":"11","year":"2023","ddc":["510"],"file":[{"relation":"main_file","file_id":"14525","creator":"dernst","file_name":"2023_PacificJourMaths_Verzobio.pdf","date_created":"2023-11-13T09:50:41Z","file_size":389897,"success":1,"checksum":"b6218d16a72742d8bb38d6fc3c9bb8c6","date_updated":"2023-11-13T09:50:41Z","access_level":"open_access","content_type":"application/pdf"}],"oa_version":"Published Version","type":"journal_article","external_id":{"arxiv":["2001.02987"],"isi":["001104766900001"]},"publication_status":"published","_id":"12313","issue":"2","publisher":"Mathematical Sciences Publishers","status":"public","author":[{"first_name":"Matteo","id":"7aa8f170-131e-11ed-88e1-a9efd01027cb","last_name":"Verzobio","full_name":"Verzobio, Matteo","orcid":"0000-0002-0854-0306"}],"abstract":[{"text":"Let P be a nontorsion point on an elliptic curve defined over a number field K and consider the sequence {Bn}n∈N of the denominators of x(nP). We prove that every term of the sequence of the Bn has a primitive divisor for n greater than an effectively computable constant that we will explicitly compute. This constant will depend only on the model defining the curve.","lang":"eng"}],"scopus_import":"1","date_updated":"2023-12-13T11:18:14Z","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","language":[{"iso":"eng"}]},{"quality_controlled":"1","citation":{"short":"A. Gómez, G. Oliveira, Scientific Reports 13 (2023).","ista":"Gómez A, Oliveira G. 2023. New approaches to epidemic modeling on networks. Scientific Reports. 13, 468.","ieee":"A. Gómez and G. Oliveira, “New approaches to epidemic modeling on networks,” <i>Scientific Reports</i>, vol. 13. Springer Nature, 2023.","ama":"Gómez A, Oliveira G. New approaches to epidemic modeling on networks. <i>Scientific Reports</i>. 2023;13. doi:<a href=\"https://doi.org/10.1038/s41598-022-19827-9\">10.1038/s41598-022-19827-9</a>","chicago":"Gómez, Arturo, and Goncalo Oliveira. “New Approaches to Epidemic Modeling on Networks.” <i>Scientific Reports</i>. Springer Nature, 2023. <a href=\"https://doi.org/10.1038/s41598-022-19827-9\">https://doi.org/10.1038/s41598-022-19827-9</a>.","apa":"Gómez, A., &#38; Oliveira, G. (2023). New approaches to epidemic modeling on networks. <i>Scientific Reports</i>. Springer Nature. <a href=\"https://doi.org/10.1038/s41598-022-19827-9\">https://doi.org/10.1038/s41598-022-19827-9</a>","mla":"Gómez, Arturo, and Goncalo Oliveira. “New Approaches to Epidemic Modeling on Networks.” <i>Scientific Reports</i>, vol. 13, 468, Springer Nature, 2023, doi:<a href=\"https://doi.org/10.1038/s41598-022-19827-9\">10.1038/s41598-022-19827-9</a>."},"date_created":"2023-01-22T23:00:55Z","oa":1,"article_number":"468","title":"New approaches to epidemic modeling on networks","date_published":"2023-01-10T00:00:00Z","has_accepted_license":"1","intvolume":"        13","acknowledgement":"Gonçalo Oliveira is supported by the NOMIS Foundation, Fundação Serrapilheira 1812-27395, by CNPq grants 428959/2018-0 and 307475/2018-2, and by FAPERJ through the grant Jovem Cientista do Nosso Estado E-26/202.793/2019.","day":"10","publication":"Scientific Reports","volume":13,"tmp":{"short":"CC BY (4.0)","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","image":"/images/cc_by.png","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode"},"article_processing_charge":"No","file_date_updated":"2023-01-23T07:53:23Z","doi":"10.1038/s41598-022-19827-9","publication_status":"published","external_id":{"isi":["001003345000051"]},"_id":"12329","oa_version":"Published Version","type":"journal_article","ddc":["510"],"file":[{"file_size":2167792,"success":1,"checksum":"a8b83739f4a951e83e0b2a778f03b327","date_created":"2023-01-23T07:53:23Z","content_type":"application/pdf","access_level":"open_access","date_updated":"2023-01-23T07:53:23Z","creator":"dernst","file_id":"12336","relation":"main_file","file_name":"2023_ScientificReports_Gomez.pdf"}],"publisher":"Springer Nature","article_type":"original","department":[{"_id":"TaHa"}],"year":"2023","month":"01","publication_identifier":{"eissn":["2045-2322"]},"isi":1,"scopus_import":"1","abstract":[{"lang":"eng","text":"In this article, we develop two independent and new approaches to model epidemic spread in a network. Contrary to the most studied models, those developed here allow for contacts with different probabilities of transmitting the disease (transmissibilities). We then examine each of these models using some mean field type approximations. The first model looks at the late-stage effects of an epidemic outbreak and allows for the computation of the probability that a given vertex was infected. This computation is based on a mean field approximation and only depends on the number of contacts and their transmissibilities. This approach shares many similarities with percolation models in networks. The second model we develop is a dynamic model which we analyze using a mean field approximation which highly reduces the dimensionality of the system. In particular, the original system which individually analyses each vertex of the network is reduced to one with as many equations as different transmissibilities. Perhaps the greatest contribution of this article is the observation that, in both these models, the existence and size of an epidemic outbreak are linked to the properties of a matrix which we call the R-matrix. This is a generalization of the basic reproduction number which more precisely characterizes the main routes of infection."}],"language":[{"iso":"eng"}],"user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","date_updated":"2023-08-01T12:31:40Z","status":"public","author":[{"full_name":"Gómez, Arturo","last_name":"Gómez","first_name":"Arturo"},{"last_name":"Oliveira","full_name":"Oliveira, Goncalo","first_name":"Goncalo","id":"58abbde8-f455-11eb-a497-98c8fd71b905"}]},{"intvolume":"        36","date_published":"2023-09-01T00:00:00Z","volume":36,"day":"01","publication":"Distributed Computing","article_processing_charge":"No","doi":"10.1007/s00446-022-00441-x","citation":{"chicago":"Aksenov, Vitalii, Dan-Adrian Alistarh, Alexandra Drozdova, and Amirkeivan Mohtashami. “The Splay-List: A Distribution-Adaptive Concurrent Skip-List.” <i>Distributed Computing</i>. Springer Nature, 2023. <a href=\"https://doi.org/10.1007/s00446-022-00441-x\">https://doi.org/10.1007/s00446-022-00441-x</a>.","apa":"Aksenov, V., Alistarh, D.-A., Drozdova, A., &#38; Mohtashami, A. (2023). The splay-list: A distribution-adaptive concurrent skip-list. <i>Distributed Computing</i>. Springer Nature. <a href=\"https://doi.org/10.1007/s00446-022-00441-x\">https://doi.org/10.1007/s00446-022-00441-x</a>","mla":"Aksenov, Vitalii, et al. “The Splay-List: A Distribution-Adaptive Concurrent Skip-List.” <i>Distributed Computing</i>, vol. 36, Springer Nature, 2023, pp. 395–418, doi:<a href=\"https://doi.org/10.1007/s00446-022-00441-x\">10.1007/s00446-022-00441-x</a>.","short":"V. Aksenov, D.-A. Alistarh, A. Drozdova, A. Mohtashami, Distributed Computing 36 (2023) 395–418.","ieee":"V. Aksenov, D.-A. Alistarh, A. Drozdova, and A. Mohtashami, “The splay-list: A distribution-adaptive concurrent skip-list,” <i>Distributed Computing</i>, vol. 36. Springer Nature, pp. 395–418, 2023.","ista":"Aksenov V, Alistarh D-A, Drozdova A, Mohtashami A. 2023. The splay-list: A distribution-adaptive concurrent skip-list. Distributed Computing. 36, 395–418.","ama":"Aksenov V, Alistarh D-A, Drozdova A, Mohtashami A. The splay-list: A distribution-adaptive concurrent skip-list. <i>Distributed Computing</i>. 2023;36:395-418. doi:<a href=\"https://doi.org/10.1007/s00446-022-00441-x\">10.1007/s00446-022-00441-x</a>"},"date_created":"2023-01-22T23:00:55Z","arxiv":1,"quality_controlled":"1","oa":1,"title":"The splay-list: A distribution-adaptive concurrent skip-list","oaworkID":1,"page":"395-418","abstract":[{"text":"The design and implementation of efficient concurrent data structures has seen significant attention. However, most of this work has focused on concurrent data structures providing good worst-case guarantees, although, in real workloads, objects are often accessed at different rates. Efficient distribution-adaptive data structures, such as splay-trees, are known in the sequential case; however, they often are hard to translate efficiently to the concurrent case. We investigate distribution-adaptive concurrent data structures, and propose a new design called the splay-list. At a high level, the splay-list is similar to a standard skip-list, with the key distinction that the height of each element adapts dynamically to its access rate: popular elements “move up,” whereas rarely-accessed elements decrease in height. We show that the splay-list provides order-optimal amortized complexity bounds for a subset of operations, while being amenable to efficient concurrent implementation. Experiments show that the splay-list can leverage distribution-adaptivity for performance, and can outperform the only previously-known distribution-adaptive concurrent design in certain workloads.","lang":"eng"}],"main_file_link":[{"open_access":"1","url":"https://doi.org/10.48550/arXiv.2008.01009"}],"scopus_import":"1","date_updated":"2025-07-22T14:06:00Z","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","language":[{"iso":"eng"}],"author":[{"full_name":"Aksenov, Vitalii","last_name":"Aksenov","first_name":"Vitalii","id":"2980135A-F248-11E8-B48F-1D18A9856A87"},{"first_name":"Dan-Adrian","id":"4A899BFC-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0003-3650-940X","full_name":"Alistarh, Dan-Adrian","last_name":"Alistarh"},{"full_name":"Drozdova, Alexandra","last_name":"Drozdova","first_name":"Alexandra"},{"first_name":"Amirkeivan","last_name":"Mohtashami","full_name":"Mohtashami, Amirkeivan"}],"status":"public","oa_version":"Preprint","type":"journal_article","_id":"12330","publication_status":"published","external_id":{"arxiv":["2008.01009"],"isi":["000913424000001"],"oaworkID":["w4390499170"]},"publisher":"Springer Nature","department":[{"_id":"DaAl"}],"article_type":"original","isi":1,"publication_identifier":{"issn":["0178-2770"],"eissn":["1432-0452"]},"year":"2023","month":"09"},{"status":"public","author":[{"first_name":"Siqi","last_name":"Wang","full_name":"Wang, Siqi"},{"last_name":"Chang","full_name":"Chang, Cheng","orcid":"0000-0002-9515-4277","first_name":"Cheng","id":"9E331C2E-9F27-11E9-AE48-5033E6697425"},{"first_name":"Shulin","last_name":"Bai","full_name":"Bai, Shulin"},{"first_name":"Bingchao","last_name":"Qin","full_name":"Qin, Bingchao"},{"first_name":"Yingcai","full_name":"Zhu, Yingcai","last_name":"Zhu"},{"full_name":"Zhan, Shaoping","last_name":"Zhan","first_name":"Shaoping"},{"full_name":"Zheng, Junqing","last_name":"Zheng","first_name":"Junqing"},{"full_name":"Tang, Shuwei","last_name":"Tang","first_name":"Shuwei"},{"full_name":"Zhao, Li Dong","last_name":"Zhao","first_name":"Li Dong"}],"language":[{"iso":"eng"}],"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","date_updated":"2023-08-14T12:57:44Z","scopus_import":"1","abstract":[{"lang":"eng","text":"High carrier mobility is critical to improving thermoelectric performance over a broad temperature range. However, traditional doping inevitably deteriorates carrier mobility. Herein, we develop a strategy for fine tuning of defects to improve carrier mobility. To begin, n-type PbTe is created by compensating for the intrinsic Pb vacancy in bare PbTe. Excess Pb2+ reduces vacancy scattering, resulting in a high carrier mobility of ∼3400 cm2 V–1 s–1. Then, excess Ag is introduced to compensate for the remaining intrinsic Pb vacancies. We find that excess Ag exhibits a dynamic doping process with increasing temperatures, increasing both the carrier concentration and carrier mobility throughout a wide temperature range; specifically, an ultrahigh carrier mobility ∼7300 cm2 V–1 s–1 is obtained for Pb1.01Te + 0.002Ag at 300 K. Moreover, the dynamic doping-induced high carrier concentration suppresses the bipolar thermal conductivity at high temperatures. The final step is using iodine to optimize the carrier concentration to ∼1019 cm–3. Ultimately, a maximum ZT value of ∼1.5 and a large average ZTave value of ∼1.0 at 300–773 K are obtained for Pb1.01Te0.998I0.002 + 0.002Ag. These findings demonstrate that fine tuning of defects with <0.5% impurities can remarkably enhance carrier mobility and improve thermoelectric performance."}],"project":[{"grant_number":"M02889","name":"Bottom-up Engineering for Thermoelectric Applications","_id":"9B8804FC-BA93-11EA-9121-9846C619BF3A"}],"month":"01","year":"2023","publication_identifier":{"issn":["0897-4756"],"eissn":["1520-5002"]},"isi":1,"article_type":"original","department":[{"_id":"MaIb"}],"publisher":"American Chemical Society","external_id":{"isi":["000914749700001"]},"publication_status":"published","issue":"2","_id":"12331","oa_version":"Published Version","ddc":["540"],"file":[{"date_updated":"2023-08-14T12:57:25Z","content_type":"application/pdf","access_level":"open_access","date_created":"2023-08-14T12:57:25Z","checksum":"b21dca2aa7a80c068bc256bdd1fea9df","success":1,"file_size":2961043,"file_name":"2023_ChemistryMaterials_Wang.pdf","relation":"main_file","creator":"dernst","file_id":"14055"}],"type":"journal_article","file_date_updated":"2023-08-14T12:57:25Z","doi":"10.1021/acs.chemmater.2c03542","tmp":{"short":"CC BY (4.0)","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","image":"/images/cc_by.png","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode"},"article_processing_charge":"No","acknowledgement":"The National Key Research and Development Program of China (2018YFA0702100), the Basic Science Center Project of the National Natural Science Foundation of China (51788104), the National Natural Science Foundation of China (51571007 and 51772012), the Beijing Natural Science Foundation (JQ18004), the 111 Project (B17002), the National Science Fund for Distinguished Young Scholars (51925101), and the FWF “Lise Meitner Fellowship” (grant agreement M2889-N). Open Access is funded by the Austrian Science Fund (FWF).","publication":"Chemistry of Materials","day":"24","volume":35,"date_published":"2023-01-24T00:00:00Z","intvolume":"        35","has_accepted_license":"1","page":"755-763","title":"Fine tuning of defects enables high carrier mobility and enhanced thermoelectric performance of n-type PbTe","oa":1,"quality_controlled":"1","citation":{"mla":"Wang, Siqi, et al. “Fine Tuning of Defects Enables High Carrier Mobility and Enhanced Thermoelectric Performance of N-Type PbTe.” <i>Chemistry of Materials</i>, vol. 35, no. 2, American Chemical Society, 2023, pp. 755–63, doi:<a href=\"https://doi.org/10.1021/acs.chemmater.2c03542\">10.1021/acs.chemmater.2c03542</a>.","apa":"Wang, S., Chang, C., Bai, S., Qin, B., Zhu, Y., Zhan, S., … Zhao, L. D. (2023). Fine tuning of defects enables high carrier mobility and enhanced thermoelectric performance of n-type PbTe. <i>Chemistry of Materials</i>. American Chemical Society. <a href=\"https://doi.org/10.1021/acs.chemmater.2c03542\">https://doi.org/10.1021/acs.chemmater.2c03542</a>","chicago":"Wang, Siqi, Cheng Chang, Shulin Bai, Bingchao Qin, Yingcai Zhu, Shaoping Zhan, Junqing Zheng, Shuwei Tang, and Li Dong Zhao. “Fine Tuning of Defects Enables High Carrier Mobility and Enhanced Thermoelectric Performance of N-Type PbTe.” <i>Chemistry of Materials</i>. American Chemical Society, 2023. <a href=\"https://doi.org/10.1021/acs.chemmater.2c03542\">https://doi.org/10.1021/acs.chemmater.2c03542</a>.","ama":"Wang S, Chang C, Bai S, et al. Fine tuning of defects enables high carrier mobility and enhanced thermoelectric performance of n-type PbTe. <i>Chemistry of Materials</i>. 2023;35(2):755-763. doi:<a href=\"https://doi.org/10.1021/acs.chemmater.2c03542\">10.1021/acs.chemmater.2c03542</a>","ista":"Wang S, Chang C, Bai S, Qin B, Zhu Y, Zhan S, Zheng J, Tang S, Zhao LD. 2023. Fine tuning of defects enables high carrier mobility and enhanced thermoelectric performance of n-type PbTe. Chemistry of Materials. 35(2), 755–763.","ieee":"S. Wang <i>et al.</i>, “Fine tuning of defects enables high carrier mobility and enhanced thermoelectric performance of n-type PbTe,” <i>Chemistry of Materials</i>, vol. 35, no. 2. American Chemical Society, pp. 755–763, 2023.","short":"S. Wang, C. Chang, S. Bai, B. Qin, Y. Zhu, S. Zhan, J. Zheng, S. Tang, L.D. Zhao, Chemistry of Materials 35 (2023) 755–763."},"date_created":"2023-01-22T23:00:55Z"},{"article_processing_charge":"No","tmp":{"short":"CC BY (4.0)","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","image":"/images/cc_by.png","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode"},"doi":"10.1126/sciadv.add6495","file_date_updated":"2023-01-23T07:45:54Z","intvolume":"         9","has_accepted_license":"1","date_published":"2023-01-20T00:00:00Z","volume":9,"publication":"Science Advances","acknowledgement":"We would like to thank K. von Peinen and B. Denker (Helmholtz Centre for Infection Research, Braunschweig, Germany) for experimental and technical assistance, respectively.\r\nThis research was supported by the Scientific Service Units (SSUs) of ISTA through resources provided by Scientific Computing (SciComp), the Life Science Facility (LSF), the Imaging and Optics facility (IOF), and the Electron Microscopy Facility (EMF). We acknowledge support from ISTA and from the Austrian Science Fund (FWF) (P33367) to F.K.M.S., from the Research Training Group GRK2223 and the Helmholtz Society to K.R,. and from the Deutsche Forschungsgemeinschaft (DFG) to J.F. and K.R.","day":"20","title":"ArpC5 isoforms regulate Arp2/3 complex–dependent protrusion through differential Ena/VASP positioning","citation":{"apa":"Fäßler, F., Javoor, M., Datler, J., Döring, H., Hofer, F., Dimchev, G. A., … Schur, F. K. (2023). ArpC5 isoforms regulate Arp2/3 complex–dependent protrusion through differential Ena/VASP positioning. <i>Science Advances</i>. American Association for the Advancement of Science. <a href=\"https://doi.org/10.1126/sciadv.add6495\">https://doi.org/10.1126/sciadv.add6495</a>","chicago":"Fäßler, Florian, Manjunath Javoor, Julia Datler, Hermann Döring, Florian Hofer, Georgi A Dimchev, Victor-Valentin Hodirnau, Jan Faix, Klemens Rottner, and Florian KM Schur. “ArpC5 Isoforms Regulate Arp2/3 Complex–Dependent Protrusion through Differential Ena/VASP Positioning.” <i>Science Advances</i>. American Association for the Advancement of Science, 2023. <a href=\"https://doi.org/10.1126/sciadv.add6495\">https://doi.org/10.1126/sciadv.add6495</a>.","mla":"Fäßler, Florian, et al. “ArpC5 Isoforms Regulate Arp2/3 Complex–Dependent Protrusion through Differential Ena/VASP Positioning.” <i>Science Advances</i>, vol. 9, no. 3, add6495, American Association for the Advancement of Science, 2023, doi:<a href=\"https://doi.org/10.1126/sciadv.add6495\">10.1126/sciadv.add6495</a>.","ama":"Fäßler F, Javoor M, Datler J, et al. ArpC5 isoforms regulate Arp2/3 complex–dependent protrusion through differential Ena/VASP positioning. <i>Science Advances</i>. 2023;9(3). doi:<a href=\"https://doi.org/10.1126/sciadv.add6495\">10.1126/sciadv.add6495</a>","short":"F. Fäßler, M. Javoor, J. Datler, H. Döring, F. Hofer, G.A. Dimchev, V.-V. Hodirnau, J. Faix, K. Rottner, F.K. Schur, Science Advances 9 (2023).","ista":"Fäßler F, Javoor M, Datler J, Döring H, Hofer F, Dimchev GA, Hodirnau V-V, Faix J, Rottner K, Schur FK. 2023. ArpC5 isoforms regulate Arp2/3 complex–dependent protrusion through differential Ena/VASP positioning. Science Advances. 9(3), add6495.","ieee":"F. Fäßler <i>et al.</i>, “ArpC5 isoforms regulate Arp2/3 complex–dependent protrusion through differential Ena/VASP positioning,” <i>Science Advances</i>, vol. 9, no. 3. American Association for the Advancement of Science, 2023."},"acknowledged_ssus":[{"_id":"ScienComp"},{"_id":"LifeSc"},{"_id":"Bio"},{"_id":"EM-Fac"}],"date_created":"2023-01-23T07:26:42Z","quality_controlled":"1","article_number":"add6495","oa":1,"author":[{"id":"404F5528-F248-11E8-B48F-1D18A9856A87","first_name":"Florian","orcid":"0000-0001-7149-769X","full_name":"Fäßler, Florian","last_name":"Fäßler"},{"full_name":"Javoor, Manjunath","last_name":"Javoor","id":"305ab18b-dc7d-11ea-9b2f-b58195228ea2","first_name":"Manjunath"},{"id":"3B12E2E6-F248-11E8-B48F-1D18A9856A87","first_name":"Julia","last_name":"Datler","full_name":"Datler, Julia","orcid":"0000-0002-3616-8580"},{"full_name":"Döring, Hermann","last_name":"Döring","first_name":"Hermann"},{"first_name":"Florian","id":"b9d234ba-9e33-11ed-95b6-cd561df280e6","full_name":"Hofer, Florian","last_name":"Hofer"},{"full_name":"Dimchev, Georgi A","last_name":"Dimchev","orcid":"0000-0001-8370-6161","id":"38C393BE-F248-11E8-B48F-1D18A9856A87","first_name":"Georgi A"},{"last_name":"Hodirnau","full_name":"Hodirnau, Victor-Valentin","id":"3661B498-F248-11E8-B48F-1D18A9856A87","first_name":"Victor-Valentin"},{"first_name":"Jan","full_name":"Faix, Jan","last_name":"Faix"},{"last_name":"Rottner","full_name":"Rottner, Klemens","first_name":"Klemens"},{"first_name":"Florian KM","id":"48AD8942-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0003-4790-8078","full_name":"Schur, Florian KM","last_name":"Schur"}],"status":"public","abstract":[{"text":"Regulation of the Arp2/3 complex is required for productive nucleation of branched actin networks. An emerging aspect of regulation is the incorporation of subunit isoforms into the Arp2/3 complex. Specifically, both ArpC5 subunit isoforms, ArpC5 and ArpC5L, have been reported to fine-tune nucleation activity and branch junction stability. We have combined reverse genetics and cellular structural biology to describe how ArpC5 and ArpC5L differentially affect cell migration. Both define the structural stability of ArpC1 in branch junctions and, in turn, by determining protrusion characteristics, affect protein dynamics and actin network ultrastructure. ArpC5 isoforms also affect the positioning of members of the Ena/Vasodilator-stimulated phosphoprotein (VASP) family of actin filament elongators, which mediate ArpC5 isoform–specific effects on the actin assembly level. Our results suggest that ArpC5 and Ena/VASP proteins are part of a signaling pathway enhancing cell migration.</jats:p>","lang":"eng"}],"related_material":{"record":[{"id":"14562","status":"public","relation":"research_data"}]},"keyword":["Multidisciplinary"],"scopus_import":"1","date_updated":"2023-11-21T08:05:35Z","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","language":[{"iso":"eng"}],"department":[{"_id":"FlSc"},{"_id":"EM-Fac"}],"article_type":"original","isi":1,"publication_identifier":{"issn":["2375-2548"]},"year":"2023","month":"01","project":[{"_id":"9B954C5C-BA93-11EA-9121-9846C619BF3A","name":"Structure and isoform diversity of the Arp2/3 complex","grant_number":"P33367"}],"oa_version":"Published Version","type":"journal_article","ddc":["570"],"file":[{"success":1,"checksum":"ce81a6d0b84170e5e8c62f6acfa15d9e","file_size":1756234,"date_created":"2023-01-23T07:45:54Z","content_type":"application/pdf","access_level":"open_access","date_updated":"2023-01-23T07:45:54Z","creator":"dernst","file_id":"12335","relation":"main_file","file_name":"2023_ScienceAdvances_Faessler.pdf"}],"issue":"3","_id":"12334","external_id":{"isi":["000964550100015"]},"publication_status":"published","publisher":"American Association for the Advancement of Science"},{"status":"public","author":[{"id":"2A485EBE-F248-11E8-B48F-1D18A9856A87","first_name":"Divyansh","orcid":"0000-0001-7400-6665","last_name":"Gupta","full_name":"Gupta, Divyansh"},{"last_name":"Mlynarski","full_name":"Mlynarski, Wiktor F","id":"358A453A-F248-11E8-B48F-1D18A9856A87","first_name":"Wiktor F"},{"first_name":"Anton L","id":"3320A096-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-4792-1881","last_name":"Sumser","full_name":"Sumser, Anton L"},{"orcid":"0000-0003-2012-9947","full_name":"Symonova, Olga","last_name":"Symonova","id":"3C0C7BC6-F248-11E8-B48F-1D18A9856A87","first_name":"Olga"},{"last_name":"Svaton","full_name":"Svaton, Jan","orcid":"0000-0002-6198-2939","first_name":"Jan","id":"f7f724c3-9d6f-11ed-9f44-e5c5f3a5bee2"},{"id":"2BD278E6-F248-11E8-B48F-1D18A9856A87","first_name":"Maximilian A","orcid":"0000-0002-3937-1330","last_name":"Jösch","full_name":"Jösch, Maximilian A"}],"date_updated":"2023-10-04T11:41:05Z","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","language":[{"iso":"eng"}],"related_material":{"record":[{"id":"12370","status":"public","relation":"research_data"}]},"abstract":[{"lang":"eng","text":"Statistics of natural scenes are not uniform - their structure varies dramatically from ground to sky. It remains unknown whether these non-uniformities are reflected in the large-scale organization of the early visual system and what benefits such adaptations would confer. Here, by relying on the efficient coding hypothesis, we predict that changes in the structure of receptive fields across visual space increase the efficiency of sensory coding. We show experimentally that, in agreement with our predictions, receptive fields of retinal ganglion cells change their shape along the dorsoventral retinal axis, with a marked surround asymmetry at the visual horizon. Our work demonstrates that, according to principles of efficient coding, the panoramic structure of natural scenes is exploited by the retina across space and cell-types."}],"scopus_import":"1","publication_identifier":{"eissn":["1546-1726"],"issn":["1097-6256"]},"isi":1,"project":[{"name":"International IST Doctoral Program","call_identifier":"H2020","_id":"2564DBCA-B435-11E9-9278-68D0E5697425","grant_number":"665385"},{"grant_number":"P34015","_id":"626c45b5-2b32-11ec-9570-e509828c1ba6","name":"Efficient coding with biophysical realism"},{"_id":"2634E9D2-B435-11E9-9278-68D0E5697425","name":"Circuits of Visual Attention","call_identifier":"H2020","grant_number":"756502"},{"_id":"266D407A-B435-11E9-9278-68D0E5697425","name":"Neuronal networks of salience and spatial detection in the murine superior colliculus","grant_number":"LT000256"},{"_id":"264FEA02-B435-11E9-9278-68D0E5697425","name":"Connecting sensory with motor processing in the superior colliculus","grant_number":"ALTF 1098-2017"}],"month":"04","year":"2023","department":[{"_id":"GradSch"},{"_id":"MaJö"}],"article_type":"original","publisher":"Springer Nature","oa_version":"Published Version","ddc":["570"],"type":"journal_article","file":[{"file_name":"2023_NatureNeuroscience_Gupta.pdf","relation":"main_file","file_id":"14395","creator":"dernst","date_updated":"2023-10-04T11:40:51Z","access_level":"open_access","content_type":"application/pdf","date_created":"2023-10-04T11:40:51Z","success":1,"checksum":"a33d91e398e548f34003170e10988368","file_size":6144866}],"publication_status":"published","external_id":{"isi":["000955258300002"],"pmid":["36959418"]},"_id":"12349","doi":"10.1038/s41593-023-01280-0","file_date_updated":"2023-10-04T11:40:51Z","tmp":{"short":"CC BY (4.0)","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","image":"/images/cc_by.png","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode"},"ec_funded":1,"article_processing_charge":"Yes (in subscription journal)","publication":"Nature Neuroscience","day":"01","acknowledgement":"We thank Hiroki Asari for sharing the dataset of naturalistic images, Anton Sumser for sharing visual stimulus code, Yoav Ben Simon for initial explorative work with the generation of AAVs, and Tomas Vega-Zuñiga for help with immunostainings. We also thank Gasper Tkacik and members of the Neuroethology group for their comments on the manuscript. This research was supported by the Scientific Service Units of IST Austria through resources provided by Scientific Computing, the Preclinical Facility, the Lab Support Facility, and the Imaging and Optics Facility. This work was supported by European Union Horizon 2020 Marie Skłodowska-Curie grant 665385 (DG), Austrian Science Fund (FWF) stand-alone grant P 34015 (WM), Human Frontiers Science Program LT000256/2018-L (AS), EMBO ALTF 1098-2017 (AS) and the European Research Council Starting Grant 756502 (MJ).","volume":26,"pmid":1,"intvolume":"        26","has_accepted_license":"1","date_published":"2023-04-01T00:00:00Z","page":"606-614","title":"Panoramic visual statistics shape retina-wide organization of receptive fields","oa":1,"citation":{"chicago":"Gupta, Divyansh, Wiktor F Mlynarski, Anton L Sumser, Olga Symonova, Jan Svaton, and Maximilian A Jösch. “Panoramic Visual Statistics Shape Retina-Wide Organization of Receptive Fields.” <i>Nature Neuroscience</i>. Springer Nature, 2023. <a href=\"https://doi.org/10.1038/s41593-023-01280-0\">https://doi.org/10.1038/s41593-023-01280-0</a>.","apa":"Gupta, D., Mlynarski, W. F., Sumser, A. L., Symonova, O., Svaton, J., &#38; Jösch, M. A. (2023). 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Divyansh, et al. <i>Research Data for: Panoramic Visual Statistics Shape Retina-Wide Organization of Receptive Fields</i>. Institute of Science and Technology Austria, 2023, doi:<a href=\"https://doi.org/10.15479/AT:ISTA:12370\">10.15479/AT:ISTA:12370</a>.","apa":"Gupta, D., Sumser, A. L., &#38; Jösch, M. A. (2023). Research Data for: Panoramic visual statistics shape retina-wide organization of receptive fields. Institute of Science and Technology Austria. <a href=\"https://doi.org/10.15479/AT:ISTA:12370\">https://doi.org/10.15479/AT:ISTA:12370</a>","chicago":"Gupta, Divyansh, Anton L Sumser, and Maximilian A Jösch. “Research Data for: Panoramic Visual Statistics Shape Retina-Wide Organization of Receptive Fields.” Institute of Science and Technology Austria, 2023. <a href=\"https://doi.org/10.15479/AT:ISTA:12370\">https://doi.org/10.15479/AT:ISTA:12370</a>.","ama":"Gupta D, Sumser AL, Jösch MA. Research Data for: Panoramic visual statistics shape retina-wide organization of receptive fields. 2023. doi:<a href=\"https://doi.org/10.15479/AT:ISTA:12370\">10.15479/AT:ISTA:12370</a>","ista":"Gupta D, Sumser AL, Jösch MA. 2023. Research Data for: Panoramic visual statistics shape retina-wide organization of receptive fields, Institute of Science and Technology Austria, <a href=\"https://doi.org/10.15479/AT:ISTA:12370\">10.15479/AT:ISTA:12370</a>.","ieee":"D. Gupta, A. L. Sumser, and M. A. Jösch, “Research Data for: Panoramic visual statistics shape retina-wide organization of receptive fields.” Institute of Science and Technology Austria, 2023.","short":"D. Gupta, A.L. Sumser, M.A. Jösch, (2023)."},"_id":"12370","publisher":"Institute of Science and Technology Austria","oa":1,"department":[{"_id":"GradSch"},{"_id":"MaJö"}],"title":"Research Data for: Panoramic visual statistics shape retina-wide organization of receptive fields","contributor":[{"last_name":"Symonova","contributor_type":"researcher","first_name":"Olga","id":"3C0C7BC6-F248-11E8-B48F-1D18A9856A87"},{"first_name":"Wiktor F","contributor_type":"researcher","id":"358A453A-F248-11E8-B48F-1D18A9856A87","last_name":"Mlynarski"},{"last_name":"Svaton","contributor_type":"researcher","first_name":"Jan","id":"f7f724c3-9d6f-11ed-9f44-e5c5f3a5bee2"}],"project":[{"grant_number":"665385","_id":"2564DBCA-B435-11E9-9278-68D0E5697425","call_identifier":"H2020","name":"International IST Doctoral Program"},{"name":"Efficient coding with biophysical realism","_id":"626c45b5-2b32-11ec-9570-e509828c1ba6","grant_number":"P34015"},{"grant_number":"756502","name":"Circuits of Visual Attention","call_identifier":"H2020","_id":"2634E9D2-B435-11E9-9278-68D0E5697425"},{"grant_number":"LT000256","_id":"266D407A-B435-11E9-9278-68D0E5697425","name":"Neuronal networks of salience and spatial detection in the murine superior colliculus"},{"name":"Connecting sensory with motor processing in the superior colliculus","_id":"264FEA02-B435-11E9-9278-68D0E5697425","grant_number":"ALTF 1098-2017"}],"month":"01","year":"2023"},{"author":[{"id":"87e34708-d6c6-11ec-9f5b-9391e7be2463","first_name":"Marek","last_name":"Chalupa","full_name":"Chalupa, Marek"},{"last_name":"Mühlböck","full_name":"Mühlböck, Fabian","orcid":"0000-0003-1548-0177","first_name":"Fabian","id":"6395C5F6-89DF-11E9-9C97-6BDFE5697425"},{"last_name":"Muroya Lei","full_name":"Muroya Lei, Stefanie","id":"a376de31-8972-11ed-ae7b-d0251c13c8ff","first_name":"Stefanie"},{"first_name":"Thomas A","id":"40876CD8-F248-11E8-B48F-1D18A9856A87","last_name":"Henzinger","full_name":"Henzinger, Thomas A","orcid":"0000-0002-2985-7724"}],"status":"public","abstract":[{"text":"As the complexity and criticality of software increase every year, so does the importance of run-time monitoring. Third-party monitoring, with limited knowledge of the monitored software, and best-effort monitoring, which keeps pace with the monitored software, are especially valuable, yet underexplored areas of run-time monitoring. Most existing monitoring frameworks do not support their combination because they either require access to the monitored code for instrumentation purposes or the processing of all observed events, or both.\r\n\r\nWe present a middleware framework, VAMOS, for the run-time monitoring of software which is explicitly designed to support third-party and best-effort scenarios. The design goals of VAMOS are (i) efficiency (keeping pace at low overhead), (ii) flexibility (the ability to monitor black-box code through a variety of different event channels, and the connectability to monitors written in different specification languages), and (iii) ease-of-use. To achieve its goals, VAMOS combines aspects of event broker and event recognition systems with aspects of stream processing systems.\r\n\r\nWe implemented a prototype toolchain for VAMOS and conducted experiments including a case study of monitoring for data races. The results indicate that VAMOS enables writing useful yet efficient monitors, is compatible with a variety of event sources and monitor specifications, and simplifies key aspects of setting up a monitoring system from scratch.","lang":"eng"}],"keyword":["runtime monitoring","best effort","third party"],"related_material":{"record":[{"id":"12856","status":"public","relation":"later_version"}]},"date_updated":"2023-04-25T07:19:06Z","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","language":[{"iso":"eng"}],"department":[{"_id":"ToHe"}],"publication_identifier":{"eissn":["2664-1690"]},"year":"2023","month":"01","project":[{"call_identifier":"H2020","name":"Vigilant Algorithmic Monitoring of Software","_id":"62781420-2b32-11ec-9570-8d9b63373d4d","grant_number":"101020093"}],"oa_version":"Published Version","file":[{"relation":"main_file","file_id":"12408","creator":"fmuehlbo","file_name":"main.pdf","date_created":"2023-01-27T03:18:34Z","file_size":662409,"success":1,"checksum":"55426e463fdeafe9777fc3ff635154c7","date_updated":"2023-01-27T03:18:34Z","access_level":"open_access","content_type":"application/pdf"}],"ddc":["005"],"type":"technical_report","_id":"12407","publication_status":"published","alternative_title":["IST Austria Technical Report"],"publisher":"Institute of Science and Technology Austria","ec_funded":1,"article_processing_charge":"No","tmp":{"short":"CC BY (4.0)","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","image":"/images/cc_by.png","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode"},"doi":"10.15479/AT:ISTA:12407","file_date_updated":"2023-01-27T03:18:34Z","has_accepted_license":"1","date_published":"2023-01-27T00:00:00Z","day":"27","acknowledgement":"This work was supported in part by the ERC-2020-AdG 101020093. \r\nThe authors would like to thank the anonymous FASE reviewers for their valuable feedback and suggestions.","title":"VAMOS: Middleware for Best-Effort Third-Party Monitoring","page":"38","citation":{"ista":"Chalupa M, Mühlböck F, Muroya Lei S, Henzinger TA. 2023. VAMOS: Middleware for Best-Effort Third-Party Monitoring, Institute of Science and Technology Austria, 38p.","ieee":"M. Chalupa, F. Mühlböck, S. Muroya Lei, and T. A. Henzinger, <i>VAMOS: Middleware for Best-Effort Third-Party Monitoring</i>. Institute of Science and Technology Austria, 2023.","short":"M. Chalupa, F. Mühlböck, S. Muroya Lei, T.A. Henzinger, VAMOS: Middleware for Best-Effort Third-Party Monitoring, Institute of Science and Technology Austria, 2023.","ama":"Chalupa M, Mühlböck F, Muroya Lei S, Henzinger TA. <i>VAMOS: Middleware for Best-Effort Third-Party Monitoring</i>. Institute of Science and Technology Austria; 2023. doi:<a href=\"https://doi.org/10.15479/AT:ISTA:12407\">10.15479/AT:ISTA:12407</a>","mla":"Chalupa, Marek, et al. <i>VAMOS: Middleware for Best-Effort Third-Party Monitoring</i>. Institute of Science and Technology Austria, 2023, doi:<a href=\"https://doi.org/10.15479/AT:ISTA:12407\">10.15479/AT:ISTA:12407</a>.","chicago":"Chalupa, Marek, Fabian Mühlböck, Stefanie Muroya Lei, and Thomas A Henzinger. <i>VAMOS: Middleware for Best-Effort Third-Party Monitoring</i>. Institute of Science and Technology Austria, 2023. <a href=\"https://doi.org/10.15479/AT:ISTA:12407\">https://doi.org/10.15479/AT:ISTA:12407</a>.","apa":"Chalupa, M., Mühlböck, F., Muroya Lei, S., &#38; Henzinger, T. A. (2023). <i>VAMOS: Middleware for Best-Effort Third-Party Monitoring</i>. Institute of Science and Technology Austria. <a href=\"https://doi.org/10.15479/AT:ISTA:12407\">https://doi.org/10.15479/AT:ISTA:12407</a>"},"date_created":"2023-01-27T03:18:08Z","oa":1},{"project":[{"grant_number":"P33367","name":"Structure and isoform diversity of the Arp2/3 complex","_id":"9B954C5C-BA93-11EA-9121-9846C619BF3A"}],"month":"02","year":"2023","publication_identifier":{"issn":["0300-5127"],"eissn":["1470-8752"]},"isi":1,"article_type":"original","department":[{"_id":"FlSc"}],"publisher":"Portland Press","publication_status":"published","external_id":{"isi":["000926043100001"]},"_id":"12421","issue":"1","ddc":["570"],"oa_version":"Published Version","type":"journal_article","file":[{"date_created":"2023-03-16T07:58:16Z","checksum":"4e7069845e3dad22bb44fb71ec624c60","success":1,"file_size":10045006,"date_updated":"2023-03-16T07:58:16Z","access_level":"open_access","content_type":"application/pdf","relation":"main_file","file_id":"12728","creator":"dernst","file_name":"2023_BioChemicalSocietyTransactions_Faessler.pdf"}],"status":"public","author":[{"orcid":"0000-0001-7149-769X","last_name":"Fäßler","full_name":"Fäßler, Florian","first_name":"Florian","id":"404F5528-F248-11E8-B48F-1D18A9856A87"},{"first_name":"Manjunath","id":"305ab18b-dc7d-11ea-9b2f-b58195228ea2","full_name":"Javoor, Manjunath","last_name":"Javoor"},{"id":"48AD8942-F248-11E8-B48F-1D18A9856A87","first_name":"Florian KM","last_name":"Schur","full_name":"Schur, Florian KM","orcid":"0000-0003-4790-8078"}],"user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","language":[{"iso":"eng"}],"date_updated":"2023-08-01T12:55:32Z","scopus_import":"1","keyword":["Biochemistry"],"abstract":[{"lang":"eng","text":"The actin cytoskeleton plays a key role in cell migration and cellular morphodynamics in most eukaryotes. The ability of the actin cytoskeleton to assemble and disassemble in a spatiotemporally controlled manner allows it to form higher-order structures, which can generate forces required for a cell to explore and navigate through its environment. It is regulated not only via a complex synergistic and competitive interplay between actin-binding proteins (ABP), but also by filament biochemistry and filament geometry. The lack of structural insights into how geometry and ABPs regulate the actin cytoskeleton limits our understanding of the molecular mechanisms that define actin cytoskeleton remodeling and, in turn, impact emerging cell migration characteristics. With the advent of cryo-electron microscopy (cryo-EM) and advanced computational methods, it is now possible to define these molecular mechanisms involving actin and its interactors at both atomic and ultra-structural levels in vitro and in cellulo. In this review, we will provide an overview of the available cryo-EM methods, applicable to further our understanding of the actin cytoskeleton, specifically in the context of cell migration. We will discuss how these methods have been employed to elucidate ABP- and geometry-defined regulatory mechanisms in initiating, maintaining, and disassembling cellular actin networks in migratory protrusions."}],"page":"87-99","title":"Deciphering the molecular mechanisms of actin cytoskeleton regulation in cell migration using cryo-EM","oa":1,"quality_controlled":"1","date_created":"2023-01-27T10:08:19Z","citation":{"ieee":"F. Fäßler, M. Javoor, and F. K. Schur, “Deciphering the molecular mechanisms of actin cytoskeleton regulation in cell migration using cryo-EM,” <i>Biochemical Society Transactions</i>, vol. 51, no. 1. Portland Press, pp. 87–99, 2023.","ista":"Fäßler F, Javoor M, Schur FK. 2023. Deciphering the molecular mechanisms of actin cytoskeleton regulation in cell migration using cryo-EM. Biochemical Society Transactions. 51(1), 87–99.","short":"F. Fäßler, M. Javoor, F.K. Schur, Biochemical Society Transactions 51 (2023) 87–99.","ama":"Fäßler F, Javoor M, Schur FK. Deciphering the molecular mechanisms of actin cytoskeleton regulation in cell migration using cryo-EM. <i>Biochemical Society Transactions</i>. 2023;51(1):87-99. doi:<a href=\"https://doi.org/10.1042/bst20220221\">10.1042/bst20220221</a>","chicago":"Fäßler, Florian, Manjunath Javoor, and Florian KM Schur. “Deciphering the Molecular Mechanisms of Actin Cytoskeleton Regulation in Cell Migration Using Cryo-EM.” <i>Biochemical Society Transactions</i>. Portland Press, 2023. <a href=\"https://doi.org/10.1042/bst20220221\">https://doi.org/10.1042/bst20220221</a>.","apa":"Fäßler, F., Javoor, M., &#38; Schur, F. K. (2023). Deciphering the molecular mechanisms of actin cytoskeleton regulation in cell migration using cryo-EM. <i>Biochemical Society Transactions</i>. Portland Press. <a href=\"https://doi.org/10.1042/bst20220221\">https://doi.org/10.1042/bst20220221</a>","mla":"Fäßler, Florian, et al. “Deciphering the Molecular Mechanisms of Actin Cytoskeleton Regulation in Cell Migration Using Cryo-EM.” <i>Biochemical Society Transactions</i>, vol. 51, no. 1, Portland Press, 2023, pp. 87–99, doi:<a href=\"https://doi.org/10.1042/bst20220221\">10.1042/bst20220221</a>."},"file_date_updated":"2023-03-16T07:58:16Z","doi":"10.1042/bst20220221","tmp":{"short":"CC BY (4.0)","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","image":"/images/cc_by.png","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode"},"article_processing_charge":"No","day":"01","publication":"Biochemical Society Transactions","acknowledgement":"We apologize for not being able to mention and cite additional excellent work that would have fit the scope of this review, due to space restraints. We thank Jesse Hansen for comments on the manuscript. We acknowledge support from the Austrian Science Fund (FWF): P33367 and the Institute of Science and Technology Austria.","volume":51,"date_published":"2023-02-01T00:00:00Z","intvolume":"        51","has_accepted_license":"1"},{"title":"Some remarks on strong approximation and applications to homogeneous spaces of linear algebraic groups","page":"907-914","quality_controlled":"1","date_created":"2023-01-29T23:00:58Z","citation":{"mla":"Balestrieri, Francesca. “Some Remarks on Strong Approximation and Applications to Homogeneous Spaces of Linear Algebraic Groups.” <i>Proceedings of the American Mathematical Society</i>, vol. 151, no. 3, American Mathematical Society, 2023, pp. 907–14, doi:<a href=\"https://doi.org/10.1090/proc/15239\">10.1090/proc/15239</a>.","chicago":"Balestrieri, Francesca. “Some Remarks on Strong Approximation and Applications to Homogeneous Spaces of Linear Algebraic Groups.” <i>Proceedings of the American Mathematical Society</i>. American Mathematical Society, 2023. <a href=\"https://doi.org/10.1090/proc/15239\">https://doi.org/10.1090/proc/15239</a>.","apa":"Balestrieri, F. (2023). Some remarks on strong approximation and applications to homogeneous spaces of linear algebraic groups. <i>Proceedings of the American Mathematical Society</i>. American Mathematical Society. <a href=\"https://doi.org/10.1090/proc/15239\">https://doi.org/10.1090/proc/15239</a>","ieee":"F. Balestrieri, “Some remarks on strong approximation and applications to homogeneous spaces of linear algebraic groups,” <i>Proceedings of the American Mathematical Society</i>, vol. 151, no. 3. American Mathematical Society, pp. 907–914, 2023.","ista":"Balestrieri F. 2023. Some remarks on strong approximation and applications to homogeneous spaces of linear algebraic groups. Proceedings of the American Mathematical Society. 151(3), 907–914.","short":"F. Balestrieri, Proceedings of the American Mathematical Society 151 (2023) 907–914.","ama":"Balestrieri F. Some remarks on strong approximation and applications to homogeneous spaces of linear algebraic groups. <i>Proceedings of the American Mathematical Society</i>. 2023;151(3):907-914. doi:<a href=\"https://doi.org/10.1090/proc/15239\">10.1090/proc/15239</a>"},"oa":1,"article_processing_charge":"No","doi":"10.1090/proc/15239","date_published":"2023-01-01T00:00:00Z","intvolume":"       151","day":"01","publication":"Proceedings of the American Mathematical Society","volume":151,"article_type":"original","department":[{"_id":"TiBr"}],"year":"2023","month":"01","publication_identifier":{"eissn":["1088-6826"],"issn":["0002-9939"]},"isi":1,"external_id":{"isi":["000898440000001"]},"publication_status":"published","issue":"3","_id":"12427","oa_version":"Preprint","type":"journal_article","publisher":"American Mathematical Society","status":"public","author":[{"id":"3ACCD756-F248-11E8-B48F-1D18A9856A87","first_name":"Francesca","full_name":"Balestrieri, Francesca","last_name":"Balestrieri"}],"scopus_import":"1","main_file_link":[{"url":"https://hal.science/hal-03013498/","open_access":"1"}],"abstract":[{"lang":"eng","text":"Let k be a number field and X a smooth, geometrically integral quasi-projective variety over k. For any linear algebraic group G over k and any G-torsor g : Z → X, we observe that if the étale-Brauer obstruction is the only one for strong approximation off a finite set of places S for all twists of Z by elements in H^1(k, G), then the étale-Brauer obstruction is the only one for strong approximation off a finite set of places S for X. As an application, we show that any homogeneous space of the form G/H with G a connected linear algebraic group over k satisfies strong approximation off the infinite places with étale-Brauer obstruction, under some compactness assumptions when k is totally real. We also prove more refined strong approximation results for homogeneous spaces of the form G/H with G semisimple simply connected and H finite, using the theory of torsors and descent."}],"user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","language":[{"iso":"eng"}],"date_updated":"2023-08-01T13:03:32Z"}]