[{"main_file_link":[{"open_access":"1","url":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3199389/"}],"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","status":"public","date_published":"2011-10-19T00:00:00Z","type":"journal_article","publist_id":"7301","oa":1,"language":[{"iso":"eng"}],"publication":"EMBO Journal","oa_version":"Submitted Version","month":"10","volume":30,"date_updated":"2021-01-12T08:01:19Z","year":"2011","citation":{"apa":"Schraivogel, D., Weinmann, L., Beier, D., Tabatabai, G., Eichner, A., Zhu, J., … Meister, G. (2011). CAMTA1 is a novel tumour suppressor regulated by miR-9/9 * in glioblastoma stem cells. <i>EMBO Journal</i>. Wiley-Blackwell. <a href=\"https://doi.org/10.1038/emboj.2011.301\">https://doi.org/10.1038/emboj.2011.301</a>","ama":"Schraivogel D, Weinmann L, Beier D, et al. CAMTA1 is a novel tumour suppressor regulated by miR-9/9 * in glioblastoma stem cells. <i>EMBO Journal</i>. 2011;30(20):4309-4322. doi:<a href=\"https://doi.org/10.1038/emboj.2011.301\">10.1038/emboj.2011.301</a>","ieee":"D. Schraivogel <i>et al.</i>, “CAMTA1 is a novel tumour suppressor regulated by miR-9/9 * in glioblastoma stem cells,” <i>EMBO Journal</i>, vol. 30, no. 20. Wiley-Blackwell, pp. 4309–4322, 2011.","chicago":"Schraivogel, Daniel, Lasse Weinmann, Dagmar Beier, Ghazaleh Tabatabai, Alexander Eichner, Jia Zhu, Martina Anton, et al. “CAMTA1 Is a Novel Tumour Suppressor Regulated by MiR-9/9 * in Glioblastoma Stem Cells.” <i>EMBO Journal</i>. Wiley-Blackwell, 2011. <a href=\"https://doi.org/10.1038/emboj.2011.301\">https://doi.org/10.1038/emboj.2011.301</a>.","mla":"Schraivogel, Daniel, et al. “CAMTA1 Is a Novel Tumour Suppressor Regulated by MiR-9/9 * in Glioblastoma Stem Cells.” <i>EMBO Journal</i>, vol. 30, no. 20, Wiley-Blackwell, 2011, pp. 4309–22, doi:<a href=\"https://doi.org/10.1038/emboj.2011.301\">10.1038/emboj.2011.301</a>.","short":"D. Schraivogel, L. Weinmann, D. Beier, G. Tabatabai, A. Eichner, J. Zhu, M. Anton, M.K. Sixt, M. Weller, C. Beier, G. Meister, EMBO Journal 30 (2011) 4309–4322.","ista":"Schraivogel D, Weinmann L, Beier D, Tabatabai G, Eichner A, Zhu J, Anton M, Sixt MK, Weller M, Beier C, Meister G. 2011. CAMTA1 is a novel tumour suppressor regulated by miR-9/9 * in glioblastoma stem cells. EMBO Journal. 30(20), 4309–4322."},"external_id":{"pmid":["21857646"]},"doi":"10.1038/emboj.2011.301","day":"19","abstract":[{"lang":"eng","text":"Cancer stem cells or cancer initiating cells are believed to contribute to cancer recurrence after therapy. MicroRNAs (miRNAs) are short RNA molecules with fundamental roles in gene regulation. The role of miRNAs in cancer stem cells is only poorly understood. Here, we report miRNA expression profiles of glioblastoma stem cell-containing CD133 + cell populations. We find that miR-9, miR-9 * (referred to as miR-9/9 *), miR-17 and miR-106b are highly abundant in CD133 + cells. Furthermore, inhibition of miR-9/9 * or miR-17 leads to reduced neurosphere formation and stimulates cell differentiation. Calmodulin-binding transcription activator 1 (CAMTA1) is a putative transcription factor, which induces the expression of the anti-proliferative cardiac hormone natriuretic peptide A (NPPA). We identify CAMTA1 as an miR-9/9 * and miR-17 target. CAMTA1 expression leads to reduced neurosphere formation and tumour growth in nude mice, suggesting that CAMTA1 can function as tumour suppressor. Consistently, CAMTA1 and NPPA expression correlate with patient survival. Our findings could provide a basis for novel strategies of glioblastoma therapy."}],"page":"4309 - 4322","quality_controlled":"1","publisher":"Wiley-Blackwell","article_type":"original","pmid":1,"_id":"518","scopus_import":1,"author":[{"first_name":"Daniel","last_name":"Schraivogel","full_name":"Schraivogel, Daniel"},{"first_name":"Lasse","last_name":"Weinmann","full_name":"Weinmann, Lasse"},{"first_name":"Dagmar","last_name":"Beier","full_name":"Beier, Dagmar"},{"full_name":"Tabatabai, Ghazaleh","first_name":"Ghazaleh","last_name":"Tabatabai"},{"full_name":"Eichner, Alexander","first_name":"Alexander","last_name":"Eichner","id":"4DFA52AE-F248-11E8-B48F-1D18A9856A87"},{"first_name":"Jia","last_name":"Zhu","full_name":"Zhu, Jia"},{"full_name":"Anton, Martina","first_name":"Martina","last_name":"Anton"},{"orcid":"0000-0002-6620-9179","full_name":"Sixt, Michael K","first_name":"Michael K","last_name":"Sixt","id":"41E9FBEA-F248-11E8-B48F-1D18A9856A87"},{"last_name":"Weller","first_name":"Michael","full_name":"Weller, Michael"},{"last_name":"Beier","first_name":"Christoph","full_name":"Beier, Christoph"},{"last_name":"Meister","first_name":"Gunter","full_name":"Meister, Gunter"}],"issue":"20","publication_status":"published","article_processing_charge":"No","department":[{"_id":"MiSi"}],"date_created":"2018-12-11T11:46:55Z","title":"CAMTA1 is a novel tumour suppressor regulated by miR-9/9 * in glioblastoma stem cells","intvolume":"        30"},{"status":"public","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","file":[{"date_updated":"2020-07-14T12:46:11Z","file_name":"IST-2015-373-v1+1_Mol._Biol._Cell-2011-Sixt-724.pdf","content_type":"application/pdf","date_created":"2018-12-12T10:17:29Z","file_size":105421,"checksum":"3467986ab7a64e7694ffd1013b5d9da9","file_id":"5283","creator":"system","relation":"main_file","access_level":"open_access"}],"publist_id":"3238","oa":1,"date_published":"2011-03-15T00:00:00Z","type":"journal_article","tmp":{"legal_code_url":"https://creativecommons.org/licenses/by-nc-sa/4.0/legalcode","name":"Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)","image":"/images/cc_by_nc_sa.png","short":"CC BY-NC-SA (4.0)"},"language":[{"iso":"eng"}],"month":"03","oa_version":"Published Version","publication":"Molecular Biology and Evolution","has_accepted_license":"1","ddc":["570"],"volume":22,"abstract":[{"lang":"eng","text":"The Minisymposium “Cell Migration and Motility” was attended by approximately 500 visitors and covered a broad range of questions in the field using diverse model systems. Topics comprised actin dynamics, cell polarity, force transduction, signal transduction, bar- rier transmigration, and chemotactic guidance."}],"doi":"10.1091/mbc.E10-12-0958","day":"15","date_updated":"2021-01-12T07:43:01Z","citation":{"short":"M.K. Sixt, C. Parent, Molecular Biology and Evolution 22 (2011) 724.","mla":"Sixt, Michael K., and Carole Parent. “Cells on the Move in Philadelphia.” <i>Molecular Biology and Evolution</i>, vol. 22, no. 6, Oxford University Press, 2011, p. 724, doi:<a href=\"https://doi.org/10.1091/mbc.E10-12-0958\">10.1091/mbc.E10-12-0958</a>.","ista":"Sixt MK, Parent C. 2011. Cells on the move in Philadelphia. Molecular Biology and Evolution. 22(6), 724.","apa":"Sixt, M. K., &#38; Parent, C. (2011). Cells on the move in Philadelphia. <i>Molecular Biology and Evolution</i>. Oxford University Press. <a href=\"https://doi.org/10.1091/mbc.E10-12-0958\">https://doi.org/10.1091/mbc.E10-12-0958</a>","ama":"Sixt MK, Parent C. Cells on the move in Philadelphia. <i>Molecular Biology and Evolution</i>. 2011;22(6):724. doi:<a href=\"https://doi.org/10.1091/mbc.E10-12-0958\">10.1091/mbc.E10-12-0958</a>","ieee":"M. K. Sixt and C. Parent, “Cells on the move in Philadelphia,” <i>Molecular Biology and Evolution</i>, vol. 22, no. 6. Oxford University Press, p. 724, 2011.","chicago":"Sixt, Michael K, and Carole Parent. “Cells on the Move in Philadelphia.” <i>Molecular Biology and Evolution</i>. Oxford University Press, 2011. <a href=\"https://doi.org/10.1091/mbc.E10-12-0958\">https://doi.org/10.1091/mbc.E10-12-0958</a>."},"year":"2011","article_type":"original","publisher":"Oxford University Press","file_date_updated":"2020-07-14T12:46:11Z","page":"724","quality_controlled":"1","pubrep_id":"373","title":"Cells on the move in Philadelphia","intvolume":"        22","publication_status":"published","date_created":"2018-12-11T12:02:57Z","department":[{"_id":"MiSi"}],"author":[{"id":"41E9FBEA-F248-11E8-B48F-1D18A9856A87","last_name":"Sixt","first_name":"Michael K","full_name":"Sixt, Michael K","orcid":"0000-0002-6620-9179"},{"full_name":"Parent, Carole","last_name":"Parent","first_name":"Carole"}],"issue":"6","_id":"3371","scopus_import":1},{"type":"journal_article","date_published":"2011-07-01T00:00:00Z","year":"2011","citation":{"ama":"Sixt MK. Interstitial locomotion of leukocytes. <i>Immunology Letters</i>. 2011;138(1):32-34. doi:<a href=\"https://doi.org/10.1016/j.imlet.2011.02.013\">10.1016/j.imlet.2011.02.013</a>","apa":"Sixt, M. K. (2011). Interstitial locomotion of leukocytes. <i>Immunology Letters</i>. Elsevier. <a href=\"https://doi.org/10.1016/j.imlet.2011.02.013\">https://doi.org/10.1016/j.imlet.2011.02.013</a>","chicago":"Sixt, Michael K. “Interstitial Locomotion of Leukocytes.” <i>Immunology Letters</i>. Elsevier, 2011. <a href=\"https://doi.org/10.1016/j.imlet.2011.02.013\">https://doi.org/10.1016/j.imlet.2011.02.013</a>.","ieee":"M. K. Sixt, “Interstitial locomotion of leukocytes,” <i>Immunology Letters</i>, vol. 138, no. 1. Elsevier, pp. 32–34, 2011.","mla":"Sixt, Michael K. “Interstitial Locomotion of Leukocytes.” <i>Immunology Letters</i>, vol. 138, no. 1, Elsevier, 2011, pp. 32–34, doi:<a href=\"https://doi.org/10.1016/j.imlet.2011.02.013\">10.1016/j.imlet.2011.02.013</a>.","short":"M.K. Sixt, Immunology Letters 138 (2011) 32–34.","ista":"Sixt MK. 2011. Interstitial locomotion of leukocytes. Immunology Letters. 138(1), 32–34."},"date_updated":"2021-01-12T07:43:07Z","publist_id":"3222","day":"01","doi":"10.1016/j.imlet.2011.02.013","status":"public","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","volume":138,"issue":"1","author":[{"last_name":"Sixt","first_name":"Michael K","full_name":"Sixt, Michael K","orcid":"0000-0002-6620-9179","id":"41E9FBEA-F248-11E8-B48F-1D18A9856A87"}],"scopus_import":1,"_id":"3385","publication":"Immunology Letters","intvolume":"       138","month":"07","title":"Interstitial locomotion of leukocytes","date_created":"2018-12-11T12:03:02Z","department":[{"_id":"MiSi"}],"oa_version":"None","publication_status":"published","language":[{"iso":"eng"}],"quality_controlled":"1","page":"32 - 34","article_type":"review","publisher":"Elsevier"},{"scopus_import":"1","_id":"3392","issue":"5","author":[{"last_name":"Soriano","first_name":"Silvia","full_name":"Soriano, Silvia"},{"orcid":"0000-0002-6625-3348","full_name":"Hons, Miroslav","first_name":"Miroslav","last_name":"Hons"},{"first_name":"Kathrin","last_name":"Schumann","full_name":"Schumann, Kathrin"},{"full_name":"Kumar, Varsha","first_name":"Varsha","last_name":"Kumar"},{"full_name":"Dennier, Timo","first_name":"Timo","last_name":"Dennier"},{"last_name":"Lyck","first_name":"Ruth","full_name":"Lyck, Ruth"},{"id":"41E9FBEA-F248-11E8-B48F-1D18A9856A87","first_name":"Michael K","last_name":"Sixt","orcid":"0000-0002-6620-9179","full_name":"Sixt, Michael K"},{"full_name":"Stein, Jens","last_name":"Stein","first_name":"Jens"}],"article_processing_charge":"No","department":[{"_id":"MiSi"}],"date_created":"2018-12-11T12:03:04Z","publication_status":"published","intvolume":"       187","title":"In vivo analysis of uropod function during physiological T cell trafficking","quality_controlled":"1","page":"2356 - 2364","publisher":"American Association of Immunologists","article_type":"original","year":"2011","citation":{"ista":"Soriano S, Hons M, Schumann K, Kumar V, Dennier T, Lyck R, Sixt MK, Stein J. 2011. In vivo analysis of uropod function during physiological T cell trafficking. Journal of Immunology. 187(5), 2356–2364.","short":"S. Soriano, M. Hons, K. Schumann, V. Kumar, T. Dennier, R. Lyck, M.K. Sixt, J. Stein, Journal of Immunology 187 (2011) 2356–2364.","mla":"Soriano, Silvia, et al. “In Vivo Analysis of Uropod Function during Physiological T Cell Trafficking.” <i>Journal of Immunology</i>, vol. 187, no. 5, American Association of Immunologists, 2011, pp. 2356–64, doi:<a href=\"https://doi.org/10.4049/jimmunol.1100935\">10.4049/jimmunol.1100935</a>.","ieee":"S. Soriano <i>et al.</i>, “In vivo analysis of uropod function during physiological T cell trafficking,” <i>Journal of Immunology</i>, vol. 187, no. 5. American Association of Immunologists, pp. 2356–2364, 2011.","chicago":"Soriano, Silvia, Miroslav Hons, Kathrin Schumann, Varsha Kumar, Timo Dennier, Ruth Lyck, Michael K Sixt, and Jens Stein. “In Vivo Analysis of Uropod Function during Physiological T Cell Trafficking.” <i>Journal of Immunology</i>. American Association of Immunologists, 2011. <a href=\"https://doi.org/10.4049/jimmunol.1100935\">https://doi.org/10.4049/jimmunol.1100935</a>.","ama":"Soriano S, Hons M, Schumann K, et al. In vivo analysis of uropod function during physiological T cell trafficking. <i>Journal of Immunology</i>. 2011;187(5):2356-2364. doi:<a href=\"https://doi.org/10.4049/jimmunol.1100935\">10.4049/jimmunol.1100935</a>","apa":"Soriano, S., Hons, M., Schumann, K., Kumar, V., Dennier, T., Lyck, R., … Stein, J. (2011). In vivo analysis of uropod function during physiological T cell trafficking. <i>Journal of Immunology</i>. American Association of Immunologists. <a href=\"https://doi.org/10.4049/jimmunol.1100935\">https://doi.org/10.4049/jimmunol.1100935</a>"},"date_updated":"2023-10-10T13:14:59Z","day":"01","doi":"10.4049/jimmunol.1100935","abstract":[{"lang":"eng","text":"Migrating lymphocytes acquire a polarized phenotype with a leading and a trailing edge, or uropod. Although in vitro experiments in cell lines or activated primary cell cultures have established that Rho-p160 coiled-coil kinase (ROCK)-myosin II-mediated uropod contractility is required for integrin de-adhesion on two-dimensional surfaces and nuclear propulsion through narrow pores in three-dimensional matrices, less is known about the role of these two events during the recirculation of primary, nonactivated lymphocytes. Using pharmacological antagonists of ROCK and myosin II, we report that inhibition of uropod contractility blocked integrin-independent mouse T cell migration through narrow, but not large, pores in vitro. T cell crawling on chemokine-coated endothelial cells under shear was severely impaired by ROCK inhibition, whereas transendothelial migration was only reduced through endothelial cells with high, but not low, barrier properties. Using three-dimensional thick-tissue imaging and dynamic two-photon microscopy of T cell motility in lymphoid tissue, we demonstrated a significant role for uropod contractility in intraluminal crawling and transendothelial migration through lymph node, but not bone marrow, endothelial cells. Finally, we demonstrated that ICAM-1, but not anatomical constraints or integrin-independent interactions, reduced parenchymal motility of inhibitor-treated T cells within the dense lymphoid microenvironment, thus assigning context-dependent roles for uropod contraction during lymphocyte recirculation."}],"volume":187,"publication":"Journal of Immunology","oa_version":"None","month":"09","language":[{"iso":"eng"}],"type":"journal_article","date_published":"2011-09-01T00:00:00Z","publication_identifier":{"eissn":["1550-6606"],"issn":["0022-1767"]},"publist_id":"3215","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","status":"public"},{"main_file_link":[{"open_access":"1","url":"https://pure.mpg.de/pubman/item/item_3219628_1/component/file_3219630/Sixt%20et%20al..pdf"}],"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","status":"public","publist_id":"2882","oa":1,"date_published":"2011-05-17T00:00:00Z","type":"journal_article","language":[{"iso":"eng"}],"oa_version":"Published Version","month":"05","publication":"Cell Migration","volume":769,"doi":"10.1007/978-1-61779-207-6_11","day":"17","abstract":[{"text":"Cell migration on two-dimensional (2D) substrates follows entirely different rules than cell migration in three-dimensional (3D) environments. This is especially relevant for leukocytes that are able to migrate in the absence of adhesion receptors within the confined geometry of artificial 3D extracellular matrix scaffolds and within the interstitial space in vivo. Here, we describe in detail a simple and economical protocol to visualize dendritic cell migration in 3D collagen scaffolds along chemotactic gradients. This method can be adapted to other cell types and may serve as a physiologically relevant paradigm for the directed locomotion of most amoeboid cells.","lang":"eng"}],"date_updated":"2021-01-12T07:43:55Z","citation":{"apa":"Sixt, M. K., &#38; Lämmermann, T. (2011). In vitro analysis of chemotactic leukocyte migration in 3D environments. <i>Cell Migration</i>. Springer. <a href=\"https://doi.org/10.1007/978-1-61779-207-6_11\">https://doi.org/10.1007/978-1-61779-207-6_11</a>","ama":"Sixt MK, Lämmermann T. In vitro analysis of chemotactic leukocyte migration in 3D environments. <i>Cell Migration</i>. 2011;769:149-165. doi:<a href=\"https://doi.org/10.1007/978-1-61779-207-6_11\">10.1007/978-1-61779-207-6_11</a>","chicago":"Sixt, Michael K, and Tim Lämmermann. “In Vitro Analysis of Chemotactic Leukocyte Migration in 3D Environments.” <i>Cell Migration</i>. Springer, 2011. <a href=\"https://doi.org/10.1007/978-1-61779-207-6_11\">https://doi.org/10.1007/978-1-61779-207-6_11</a>.","ieee":"M. K. Sixt and T. Lämmermann, “In vitro analysis of chemotactic leukocyte migration in 3D environments,” <i>Cell Migration</i>, vol. 769. Springer, pp. 149–165, 2011.","mla":"Sixt, Michael K., and Tim Lämmermann. “In Vitro Analysis of Chemotactic Leukocyte Migration in 3D Environments.” <i>Cell Migration</i>, vol. 769, Springer, 2011, pp. 149–65, doi:<a href=\"https://doi.org/10.1007/978-1-61779-207-6_11\">10.1007/978-1-61779-207-6_11</a>.","short":"M.K. Sixt, T. Lämmermann, Cell Migration 769 (2011) 149–165.","ista":"Sixt MK, Lämmermann T. 2011. In vitro analysis of chemotactic leukocyte migration in 3D environments. Cell Migration. 769, 149–165."},"year":"2011","publisher":"Springer","article_type":"original","page":"149 - 165","quality_controlled":"1","publication_status":"published","department":[{"_id":"MiSi"}],"date_created":"2018-12-11T12:03:41Z","article_processing_charge":"No","title":"In vitro analysis of chemotactic leukocyte migration in 3D environments","alternative_title":["Methods in Molecular Biology"],"intvolume":"       769","_id":"3505","author":[{"id":"41E9FBEA-F248-11E8-B48F-1D18A9856A87","first_name":"Michael K","last_name":"Sixt","orcid":"0000-0002-6620-9179","full_name":"Sixt, Michael K"},{"full_name":"Lämmermann, Tim","first_name":"Tim","last_name":"Lämmermann"}]}]