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46 Publications
2020 | Published | Journal Article | IST-REx-ID: 8318 | 
Key role of quinone in the mechanism of respiratory complex I
J. Gutierrez-Fernandez, K. Kaszuba, G.S. Minhas, R. Baradaran, M. Tambalo, D.T. Gallagher, L.A. Sazanov, Nature Communications 11 (2020).
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J. Gutierrez-Fernandez, K. Kaszuba, G.S. Minhas, R. Baradaran, M. Tambalo, D.T. Gallagher, L.A. Sazanov, Nature Communications 11 (2020).
2020 | Published | Thesis | IST-REx-ID: 8340 |
Molecular mechanisms of mitochondrial redox-coupled proton pumping enzymes
D. Kampjut, Molecular Mechanisms of Mitochondrial Redox-Coupled Proton Pumping Enzymes, Institute of Science and Technology Austria, 2020.
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D. Kampjut, Molecular Mechanisms of Mitochondrial Redox-Coupled Proton Pumping Enzymes, Institute of Science and Technology Austria, 2020.
2020 | Published | Thesis | IST-REx-ID: 8353 |
Biochemical and structural investigation of the Mrp antiporter, an ancestor of complex I
J. Steiner, Biochemical and Structural Investigation of the Mrp Antiporter, an Ancestor of Complex I, Institute of Science and Technology Austria, 2020.
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J. Steiner, Biochemical and Structural Investigation of the Mrp Antiporter, an Ancestor of Complex I, Institute of Science and Technology Austria, 2020.
2020 | Published | Journal Article | IST-REx-ID: 8579 |
Cu homeostasis in bacteria: The ins and outs
A. Andrei, Y. Öztürk, B. Khalfaoui-Hassani, J. Rauch, D. Marckmann, P.I. Trasnea, F. Daldal, H.-G. Koch, Membranes 10 (2020).
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A. Andrei, Y. Öztürk, B. Khalfaoui-Hassani, J. Rauch, D. Marckmann, P.I. Trasnea, F. Daldal, H.-G. Koch, Membranes 10 (2020).
2020 | Published | Journal Article | IST-REx-ID: 8581
Cryo-EM structure of the entire mammalian F-type ATP synthase
G. Pinke, L. Zhou, L.A. Sazanov, Nature Structural and Molecular Biology 27 (2020) 1077–1085.
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G. Pinke, L. Zhou, L.A. Sazanov, Nature Structural and Molecular Biology 27 (2020) 1077–1085.
2020 | Published | Journal Article | IST-REx-ID: 8737 |
The coupling mechanism of mammalian respiratory complex I
D. Kampjut, L.A. Sazanov, Science 370 (2020).
[Submitted Version]
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D. Kampjut, L.A. Sazanov, Science 370 (2020).
2020 | Research Data Reference | IST-REx-ID: 9326 |
Charge transfer and chemo-mechanical coupling in respiratory complex I
C. Gupta, U. Khaniya, C. Chan, F. Dehez, M. Shekhar, M.R. Gunner, L.A. Sazanov, C. Chipot, A. Singharoy, (2020).
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C. Gupta, U. Khaniya, C. Chan, F. Dehez, M. Shekhar, M.R. Gunner, L.A. Sazanov, C. Chipot, A. Singharoy, (2020).
2020 | Research Data Reference | IST-REx-ID: 9713
Supporting information
C. Gupta, U. Khaniya, C.K. Chan, F. Dehez, M. Shekhar, M.R. Gunner, L.A. Sazanov, C. Chipot, A. Singharoy, (2020).
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C. Gupta, U. Khaniya, C.K. Chan, F. Dehez, M. Shekhar, M.R. Gunner, L.A. Sazanov, C. Chipot, A. Singharoy, (2020).
2020 | Research Data Reference | IST-REx-ID: 9878
Movies
C. Gupta, U. Khaniya, C.K. Chan, F. Dehez, M. Shekhar, M.R. Gunner, L.A. Sazanov, C. Chipot, A. Singharoy, (2020).
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C. Gupta, U. Khaniya, C.K. Chan, F. Dehez, M. Shekhar, M.R. Gunner, L.A. Sazanov, C. Chipot, A. Singharoy, (2020).
2019 | Published | Journal Article | IST-REx-ID: 6352 |
Protective properties of the cultured stem cell proteome studied in an animal model of acetaminophen-induced acute liver failure
A.A. Temnov, K.A. Rogov, A.N. Sklifas, E.V. Klychnikova, M. Hartl, K. Djinovic-Carugo, A. Charnagalov, Molecular Biology Reports (2019).
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A.A. Temnov, K.A. Rogov, A.N. Sklifas, E.V. Klychnikova, M. Hartl, K. Djinovic-Carugo, A. Charnagalov, Molecular Biology Reports (2019).
2019 | Published | Journal Article | IST-REx-ID: 6848 |
Structure and mechanism of mitochondrial proton-translocating transhydrogenase
D. Kampjut, L.A. Sazanov, Nature 573 (2019) 291–295.
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D. Kampjut, L.A. Sazanov, Nature 573 (2019) 291–295.
2019 | Published | Journal Article | IST-REx-ID: 6859
Structure and conformational plasticity of the intact Thermus thermophilus V/A-type ATPase
L. Zhou, L.A. Sazanov, Science 365 (2019).
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L. Zhou, L.A. Sazanov, Science 365 (2019).
2019 | Published | Journal Article | IST-REx-ID: 6919 |
Structural basis of sterol recognition by human hedgehog receptor PTCH1
C. Qi, G.D. Minin, I. Vercellino, A. Wutz, V.M. Korkhov, Science Advances 5 (2019).
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C. Qi, G.D. Minin, I. Vercellino, A. Wutz, V.M. Korkhov, Science Advances 5 (2019).
2019 | Published | Journal Article | IST-REx-ID: 7395 |
Structures of respiratory supercomplex I+III2 reveal functional and conformational crosstalk
J.A. Letts, K. Fiedorczuk, G. Degliesposti, M. Skehel, L.A. Sazanov, Molecular Cell 75 (2019) 1131–1146.e6.
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J.A. Letts, K. Fiedorczuk, G. Degliesposti, M. Skehel, L.A. Sazanov, Molecular Cell 75 (2019) 1131–1146.e6.
2018 | Published | Journal Article | IST-REx-ID: 152 |
Mammalian mitochondrial complex I structure and disease causing mutations
K. Fiedorczuk, L.A. Sazanov, Trends in Cell Biology 28 (2018) 835–867.
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K. Fiedorczuk, L.A. Sazanov, Trends in Cell Biology 28 (2018) 835–867.
2017 | Published | Book Chapter | IST-REx-ID: 444
Structure of respiratory complex I: “Minimal” bacterial and “de luxe” mammalian versions
L.A. Sazanov, in:, M. Wikström (Ed.), Mechanisms of Primary Energy Transduction in Biology , Royal Society of Chemistry, 2017, pp. 25–59.
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L.A. Sazanov, in:, M. Wikström (Ed.), Mechanisms of Primary Energy Transduction in Biology , Royal Society of Chemistry, 2017, pp. 25–59.
2017 | Published | Journal Article | IST-REx-ID: 515 |
Clarifying the supercomplex: The higher-order organization of the mitochondrial electron transport chain
J.A. Letts, L.A. Sazanov, Nature Structural and Molecular Biology 24 (2017) 800–808.
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J.A. Letts, L.A. Sazanov, Nature Structural and Molecular Biology 24 (2017) 800–808.
2016 | Published | Journal Article | IST-REx-ID: 1226 |
Atomic structure of the entire mammalian mitochondrial complex i
K. Fiedorczuk, J.A. Letts, G. Degliesposti, K. Kaszuba, M. Skehel, L.A. Sazanov, Nature 538 (2016) 406–410.
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K. Fiedorczuk, J.A. Letts, G. Degliesposti, K. Kaszuba, M. Skehel, L.A. Sazanov, Nature 538 (2016) 406–410.
2016 | Published | Journal Article | IST-REx-ID: 1232
The architecture of respiratory supercomplexes
J.A. Letts, K. Fiedorczuk, L.A. Sazanov, Nature 537 (2016) 644–648.
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J.A. Letts, K. Fiedorczuk, L.A. Sazanov, Nature 537 (2016) 644–648.
2016 | Published | Journal Article | IST-REx-ID: 1276 |
Atomistic determinants of co-enzyme Q reduction at the Qi-site of the cytochrome bc1 complex
P. Postila, K. Kaszuba, P. Kuleta, I. Vattulainen, M. Sarewicz, A. Osyczka, T. Róg, Scientific Reports 6 (2016).
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P. Postila, K. Kaszuba, P. Kuleta, I. Vattulainen, M. Sarewicz, A. Osyczka, T. Róg, Scientific Reports 6 (2016).