---
_id: '10642'
abstract:
- lang: eng
text: Based on a result by Yarotsky (J Stat Phys 118, 2005), we prove that localized
but otherwise arbitrary perturbations of weakly interacting quantum spin systems
with uniformly gapped on-site terms change the ground state of such a system only
locally, even if they close the spectral gap. We call this a strong version of
the local perturbations perturb locally (LPPL) principle which is known to hold
for much more general gapped systems, but only for perturbations that do not close
the spectral gap of the Hamiltonian. We also extend this strong LPPL-principle
to Hamiltonians that have the appropriate structure of gapped on-site terms and
weak interactions only locally in some region of space. While our results are
technically corollaries to a theorem of Yarotsky, we expect that the paradigm
of systems with a locally gapped ground state that is completely insensitive to
the form of the Hamiltonian elsewhere extends to other situations and has important
physical consequences.
acknowledgement: J. H. acknowledges partial financial support by the ERC Advanced
Grant “RMTBeyond” No. 101020331. S. T. thanks Marius Lemm and Simone Warzel for
very helpful comments and discussions and Jürg Fröhlich for references to the literature.
Open Access funding enabled and organized by Projekt DEAL.
article_number: '9'
article_processing_charge: No
article_type: original
arxiv: 1
author:
- first_name: Sven Joscha
full_name: Henheik, Sven Joscha
id: 31d731d7-d235-11ea-ad11-b50331c8d7fb
last_name: Henheik
orcid: 0000-0003-1106-327X
- first_name: Stefan
full_name: Teufel, Stefan
last_name: Teufel
- first_name: Tom
full_name: Wessel, Tom
last_name: Wessel
citation:
ama: Henheik SJ, Teufel S, Wessel T. Local stability of ground states in locally
gapped and weakly interacting quantum spin systems. Letters in Mathematical
Physics. 2022;112(1). doi:10.1007/s11005-021-01494-y
apa: Henheik, S. J., Teufel, S., & Wessel, T. (2022). Local stability of ground
states in locally gapped and weakly interacting quantum spin systems. Letters
in Mathematical Physics. Springer Nature. https://doi.org/10.1007/s11005-021-01494-y
chicago: Henheik, Sven Joscha, Stefan Teufel, and Tom Wessel. “Local Stability of
Ground States in Locally Gapped and Weakly Interacting Quantum Spin Systems.”
Letters in Mathematical Physics. Springer Nature, 2022. https://doi.org/10.1007/s11005-021-01494-y.
ieee: S. J. Henheik, S. Teufel, and T. Wessel, “Local stability of ground states
in locally gapped and weakly interacting quantum spin systems,” Letters in
Mathematical Physics, vol. 112, no. 1. Springer Nature, 2022.
ista: Henheik SJ, Teufel S, Wessel T. 2022. Local stability of ground states in
locally gapped and weakly interacting quantum spin systems. Letters in Mathematical
Physics. 112(1), 9.
mla: Henheik, Sven Joscha, et al. “Local Stability of Ground States in Locally Gapped
and Weakly Interacting Quantum Spin Systems.” Letters in Mathematical Physics,
vol. 112, no. 1, 9, Springer Nature, 2022, doi:10.1007/s11005-021-01494-y.
short: S.J. Henheik, S. Teufel, T. Wessel, Letters in Mathematical Physics 112 (2022).
date_created: 2022-01-18T16:18:25Z
date_published: 2022-01-18T00:00:00Z
date_updated: 2023-08-02T13:57:02Z
day: '18'
ddc:
- '530'
department:
- _id: GradSch
- _id: LaEr
doi: 10.1007/s11005-021-01494-y
ec_funded: 1
external_id:
arxiv:
- '2106.13780'
isi:
- '000744930400001'
file:
- access_level: open_access
checksum: 7e8e69b76e892c305071a4736131fe18
content_type: application/pdf
creator: cchlebak
date_created: 2022-01-19T09:41:14Z
date_updated: 2022-01-19T09:41:14Z
file_id: '10647'
file_name: 2022_LettersMathPhys_Henheik.pdf
file_size: 357547
relation: main_file
success: 1
file_date_updated: 2022-01-19T09:41:14Z
has_accepted_license: '1'
intvolume: ' 112'
isi: 1
issue: '1'
keyword:
- mathematical physics
- statistical and nonlinear physics
language:
- iso: eng
month: '01'
oa: 1
oa_version: Published Version
project:
- _id: 62796744-2b32-11ec-9570-940b20777f1d
call_identifier: H2020
grant_number: '101020331'
name: Random matrices beyond Wigner-Dyson-Mehta
publication: Letters in Mathematical Physics
publication_identifier:
eissn:
- 1573-0530
issn:
- 0377-9017
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
status: public
title: Local stability of ground states in locally gapped and weakly interacting quantum
spin systems
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 112
year: '2022'
...
---
_id: '10643'
abstract:
- lang: eng
text: "We prove a generalised super-adiabatic theorem for extended fermionic systems
assuming a spectral gap only in the bulk. More precisely, we assume that the infinite
system has a unique ground state and that the corresponding Gelfand–Naimark–Segal
Hamiltonian has a spectral gap above its eigenvalue zero. Moreover, we show that
a similar adiabatic theorem also holds in the bulk of finite systems up to errors
that vanish faster than any inverse power of the system size, although the corresponding
finite-volume Hamiltonians need not have a spectral gap.\r\n\r\n"
acknowledgement: J.H. acknowledges partial financial support by the ERC Advanced Grant
‘RMTBeyond’ No. 101020331. Support for publication costs from the Deutsche Forschungsgemeinschaft
and the Open Access Publishing Fund of the University of Tübingen is gratefully
acknowledged.
article_number: e4
article_processing_charge: Yes
article_type: original
arxiv: 1
author:
- first_name: Sven Joscha
full_name: Henheik, Sven Joscha
id: 31d731d7-d235-11ea-ad11-b50331c8d7fb
last_name: Henheik
orcid: 0000-0003-1106-327X
- first_name: Stefan
full_name: Teufel, Stefan
last_name: Teufel
citation:
ama: 'Henheik SJ, Teufel S. Adiabatic theorem in the thermodynamic limit: Systems
with a gap in the bulk. Forum of Mathematics, Sigma. 2022;10. doi:10.1017/fms.2021.80'
apa: 'Henheik, S. J., & Teufel, S. (2022). Adiabatic theorem in the thermodynamic
limit: Systems with a gap in the bulk. Forum of Mathematics, Sigma. Cambridge
University Press. https://doi.org/10.1017/fms.2021.80'
chicago: 'Henheik, Sven Joscha, and Stefan Teufel. “Adiabatic Theorem in the Thermodynamic
Limit: Systems with a Gap in the Bulk.” Forum of Mathematics, Sigma. Cambridge
University Press, 2022. https://doi.org/10.1017/fms.2021.80.'
ieee: 'S. J. Henheik and S. Teufel, “Adiabatic theorem in the thermodynamic limit:
Systems with a gap in the bulk,” Forum of Mathematics, Sigma, vol. 10.
Cambridge University Press, 2022.'
ista: 'Henheik SJ, Teufel S. 2022. Adiabatic theorem in the thermodynamic limit:
Systems with a gap in the bulk. Forum of Mathematics, Sigma. 10, e4.'
mla: 'Henheik, Sven Joscha, and Stefan Teufel. “Adiabatic Theorem in the Thermodynamic
Limit: Systems with a Gap in the Bulk.” Forum of Mathematics, Sigma, vol.
10, e4, Cambridge University Press, 2022, doi:10.1017/fms.2021.80.'
short: S.J. Henheik, S. Teufel, Forum of Mathematics, Sigma 10 (2022).
date_created: 2022-01-18T16:18:51Z
date_published: 2022-01-18T00:00:00Z
date_updated: 2023-08-02T13:53:11Z
day: '18'
ddc:
- '510'
department:
- _id: GradSch
- _id: LaEr
doi: 10.1017/fms.2021.80
ec_funded: 1
external_id:
arxiv:
- '2012.15239'
isi:
- '000743615000001'
file:
- access_level: open_access
checksum: 87592a755adcef22ea590a99dc728dd3
content_type: application/pdf
creator: cchlebak
date_created: 2022-01-19T09:27:43Z
date_updated: 2022-01-19T09:27:43Z
file_id: '10646'
file_name: 2022_ForumMathSigma_Henheik.pdf
file_size: 705323
relation: main_file
success: 1
file_date_updated: 2022-01-19T09:27:43Z
has_accepted_license: '1'
intvolume: ' 10'
isi: 1
keyword:
- computational mathematics
- discrete mathematics and combinatorics
- geometry and topology
- mathematical physics
- statistics and probability
- algebra and number theory
- theoretical computer science
- analysis
language:
- iso: eng
month: '01'
oa: 1
oa_version: Published Version
project:
- _id: 62796744-2b32-11ec-9570-940b20777f1d
call_identifier: H2020
grant_number: '101020331'
name: Random matrices beyond Wigner-Dyson-Mehta
publication: Forum of Mathematics, Sigma
publication_identifier:
eissn:
- 2050-5094
publication_status: published
publisher: Cambridge University Press
quality_controlled: '1'
status: public
title: 'Adiabatic theorem in the thermodynamic limit: Systems with a gap in the bulk'
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 10
year: '2022'
...
---
_id: '10652'
abstract:
- lang: eng
text: Finding a feasible scheme for testing the quantum mechanical nature of the
gravitational interaction has been attracting an increasing level of attention.
Gravity mediated entanglement generation so far appears to be the key ingredient
for a potential experiment. In a recent proposal [D. Carney et al., PRX Quantum
2, 030330 (2021)] combining an atom interferometer with a low-frequency mechanical
oscillator, a coherence revival test is proposed for verifying this entanglement
generation. With measurements performed only on the atoms, this protocol bypasses
the need for correlation measurements. Here, we explore formulations of such a
protocol, and specifically find that in the envisioned regime of operation with
high thermal excitation, semiclassical models, where there is no concept of entanglement,
also give the same experimental signatures. We elucidate in a fully quantum mechanical
calculation that entanglement is not the source of the revivals in the relevant
parameter regime. We argue that, in its current form, the suggested test is only
relevant if the oscillator is nearly in a pure quantum state, and in this regime
the effects are too small to be measurable. We further discuss potential open
ends. The results highlight the importance and subtleties of explicitly considering
how the quantum case differs from the classical expectations when testing for
the quantum mechanical nature of a physical system.
acknowledgement: O.H. is supported by Institute of Science and Technology Austria.
The author thanks Jess Riedel for discussions.
article_number: '013023'
article_processing_charge: Yes (via OA deal)
article_type: original
author:
- first_name: Onur
full_name: Hosten, Onur
id: 4C02D85E-F248-11E8-B48F-1D18A9856A87
last_name: Hosten
orcid: 0000-0002-2031-204X
citation:
ama: Hosten O. Constraints on probing quantum coherence to infer gravitational entanglement.
Physical Review Research. 2022;4(1). doi:10.1103/PhysRevResearch.4.013023
apa: Hosten, O. (2022). Constraints on probing quantum coherence to infer gravitational
entanglement. Physical Review Research. American Physical Society. https://doi.org/10.1103/PhysRevResearch.4.013023
chicago: Hosten, Onur. “Constraints on Probing Quantum Coherence to Infer Gravitational
Entanglement.” Physical Review Research. American Physical Society, 2022.
https://doi.org/10.1103/PhysRevResearch.4.013023.
ieee: O. Hosten, “Constraints on probing quantum coherence to infer gravitational
entanglement,” Physical Review Research, vol. 4, no. 1. American Physical
Society, 2022.
ista: Hosten O. 2022. Constraints on probing quantum coherence to infer gravitational
entanglement. Physical Review Research. 4(1), 013023.
mla: Hosten, Onur. “Constraints on Probing Quantum Coherence to Infer Gravitational
Entanglement.” Physical Review Research, vol. 4, no. 1, 013023, American
Physical Society, 2022, doi:10.1103/PhysRevResearch.4.013023.
short: O. Hosten, Physical Review Research 4 (2022).
date_created: 2022-01-23T23:01:27Z
date_published: 2022-01-10T00:00:00Z
date_updated: 2022-05-16T11:21:38Z
day: '10'
ddc:
- '530'
department:
- _id: OnHo
doi: 10.1103/PhysRevResearch.4.013023
file:
- access_level: open_access
checksum: 7254d267a0633ca5d63131d345e58686
content_type: application/pdf
creator: cchlebak
date_created: 2022-01-24T11:12:44Z
date_updated: 2022-01-24T11:12:44Z
file_id: '10660'
file_name: 2022_PhysRevResearch_Hosten.pdf
file_size: 236329
relation: main_file
success: 1
file_date_updated: 2022-01-24T11:12:44Z
has_accepted_license: '1'
intvolume: ' 4'
issue: '1'
language:
- iso: eng
month: '01'
oa: 1
oa_version: Published Version
publication: Physical Review Research
publication_identifier:
issn:
- 2643-1564
publication_status: published
publisher: American Physical Society
quality_controlled: '1'
scopus_import: '1'
status: public
title: Constraints on probing quantum coherence to infer gravitational entanglement
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 4
year: '2022'
...
---
_id: '10653'
abstract:
- lang: eng
text: Squall lines are known to be the consequence of the interaction of low-level
shear with cold pools associated with convective downdrafts. Also, as the magnitude
of the shear increases beyond a critical shear, squall lines tend to orient themselves.
The existing literature suggests that this orientation reduces incoming wind shear
to the squall line, and maintains equilibrium between wind shear and cold pool
spreading. Although this theory is widely accepted, very few quantitative studies
have been conducted on supercritical regime especially. Here, we test this hypothesis
with tropical squall lines obtained by imposing a vertical wind shear in cloud
resolving simulations in radiative convective equilibrium. In the sub-critical
regime, squall lines are perpendicular to the shear. In the super-critical regime,
their orientation maintain the equilibrium, supporting existing theories. We also
find that as shear increases, cold pools become more intense. However, this intensification
has little impact on squall line orientation.
acknowledgement: The authors gratefully acknowledge funding from the European Research
Council (ERC) under the European Union's Horizon 2020 research and innovation program
(Project CLUSTER, Grant Agreement No. 805041), and from the PhD fellowship of Ecole
Normale Supérieure de Paris-Saclay. Two supplementary movies are also provided showing
the angle detection method and the squall line of the Usfc = 10 m s−1 simulation.
article_number: e2021GL095184
article_processing_charge: No
article_type: original
author:
- first_name: Sophie
full_name: Abramian, Sophie
last_name: Abramian
- first_name: Caroline J
full_name: Muller, Caroline J
id: f978ccb0-3f7f-11eb-b193-b0e2bd13182b
last_name: Muller
orcid: 0000-0001-5836-5350
- first_name: Camille
full_name: Risi, Camille
last_name: Risi
citation:
ama: Abramian S, Muller CJ, Risi C. Shear-convection interactions and orientation
of tropical squall lines. Geophysical Research Letters. 2022;49(1). doi:10.1029/2021GL095184
apa: Abramian, S., Muller, C. J., & Risi, C. (2022). Shear-convection interactions
and orientation of tropical squall lines. Geophysical Research Letters.
Wiley. https://doi.org/10.1029/2021GL095184
chicago: Abramian, Sophie, Caroline J Muller, and Camille Risi. “Shear-Convection
Interactions and Orientation of Tropical Squall Lines.” Geophysical Research
Letters. Wiley, 2022. https://doi.org/10.1029/2021GL095184.
ieee: S. Abramian, C. J. Muller, and C. Risi, “Shear-convection interactions and
orientation of tropical squall lines,” Geophysical Research Letters, vol.
49, no. 1. Wiley, 2022.
ista: Abramian S, Muller CJ, Risi C. 2022. Shear-convection interactions and orientation
of tropical squall lines. Geophysical Research Letters. 49(1), e2021GL095184.
mla: Abramian, Sophie, et al. “Shear-Convection Interactions and Orientation of
Tropical Squall Lines.” Geophysical Research Letters, vol. 49, no. 1, e2021GL095184,
Wiley, 2022, doi:10.1029/2021GL095184.
short: S. Abramian, C.J. Muller, C. Risi, Geophysical Research Letters 49 (2022).
date_created: 2022-01-23T23:01:27Z
date_published: 2022-01-16T00:00:00Z
date_updated: 2023-08-02T14:00:17Z
day: '16'
ddc:
- '550'
department:
- _id: CaMu
doi: 10.1029/2021GL095184
ec_funded: 1
external_id:
isi:
- '000743989800040'
file:
- access_level: open_access
checksum: 08f88b57b8e409b42e382452cd5f297b
content_type: application/pdf
creator: cchlebak
date_created: 2022-01-24T12:14:41Z
date_updated: 2022-01-24T12:14:41Z
file_id: '10662'
file_name: 2022_GeophysResearchLet_Abramian.pdf
file_size: 1117408
relation: main_file
success: 1
file_date_updated: 2022-01-24T12:14:41Z
has_accepted_license: '1'
intvolume: ' 49'
isi: 1
issue: '1'
language:
- iso: eng
month: '01'
oa: 1
oa_version: Published Version
project:
- _id: 629205d8-2b32-11ec-9570-e1356ff73576
call_identifier: H2020
grant_number: '805041'
name: organization of CLoUdS, and implications of Tropical cyclones and for the
Energetics of the tropics, in current and waRming climate
publication: Geophysical Research Letters
publication_identifier:
eissn:
- 1944-8007
issn:
- 0094-8276
publication_status: published
publisher: Wiley
quality_controlled: '1'
related_material:
link:
- relation: earlier_version
url: https://doi.org/10.1002/essoar.10507697.1
scopus_import: '1'
status: public
title: Shear-convection interactions and orientation of tropical squall lines
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 49
year: '2022'
...
---
_id: '10654'
abstract:
- lang: eng
text: "Directed percolation (DP) has recently emerged as a possible solution to
the century old puzzle surrounding the transition to turbulence. Multiple model
studies reported DP exponents, however, experimental evidence is limited since
the largest possible observation times are orders of magnitude shorter than the
flows’ characteristic timescales. An exception is cylindrical Couette flow where
the limit is not temporal, but rather the realizable system size. We present experiments
in a Couette setup of unprecedented azimuthal and axial aspect ratios. Approaching
the critical point to within less than 0.1% we determine five critical exponents,
all of which are in excellent agreement with the 2+1D DP universality class. The
complex dynamics encountered at \r\nthe onset of turbulence can hence be fully
rationalized within the framework of statistical mechanics."
acknowledged_ssus:
- _id: M-Shop
acknowledgement: "We thank T.Menner, T.Asenov, P. Maier and the Miba machine shop
of IST Austria for their valuable support in all technical aspects. We thank Marc
Avila for comments on the manuscript. This work was supported by a grant from the
Simons Foundation (662960, B.H.). We acknowledge the European Research Council under
the European Union’s Seventh Framework Programme (FP/2007-2013)/ERC Grant Agreement
306589 for financial support. K.A.\r\nacknowledges funding from the Central Research
Development Fund of the University of Bremen, grant number ZF04B /2019/FB04 Avila
Kerstin (”Independent Project for Postdocs”). L.K. was supported by the European
Union’s Horizon 2020 Research and innovation programme under the Marie Sklodowska-Curie
grant agreement No. 754411.\r\n"
article_number: '014502'
article_processing_charge: No
article_type: original
arxiv: 1
author:
- first_name: Lukasz
full_name: Klotz, Lukasz
id: 2C9AF1C2-F248-11E8-B48F-1D18A9856A87
last_name: Klotz
orcid: 0000-0003-1740-7635
- first_name: Grégoire M
full_name: Lemoult, Grégoire M
id: 4787FE80-F248-11E8-B48F-1D18A9856A87
last_name: Lemoult
- first_name: Kerstin
full_name: Avila, Kerstin
last_name: Avila
- first_name: Björn
full_name: Hof, Björn
id: 3A374330-F248-11E8-B48F-1D18A9856A87
last_name: Hof
orcid: 0000-0003-2057-2754
citation:
ama: Klotz L, Lemoult GM, Avila K, Hof B. Phase transition to turbulence in spatially
extended shear flows. Physical Review Letters. 2022;128(1). doi:10.1103/PhysRevLett.128.014502
apa: Klotz, L., Lemoult, G. M., Avila, K., & Hof, B. (2022). Phase transition
to turbulence in spatially extended shear flows. Physical Review Letters.
American Physical Society. https://doi.org/10.1103/PhysRevLett.128.014502
chicago: Klotz, Lukasz, Grégoire M Lemoult, Kerstin Avila, and Björn Hof. “Phase
Transition to Turbulence in Spatially Extended Shear Flows.” Physical Review
Letters. American Physical Society, 2022. https://doi.org/10.1103/PhysRevLett.128.014502.
ieee: L. Klotz, G. M. Lemoult, K. Avila, and B. Hof, “Phase transition to turbulence
in spatially extended shear flows,” Physical Review Letters, vol. 128,
no. 1. American Physical Society, 2022.
ista: Klotz L, Lemoult GM, Avila K, Hof B. 2022. Phase transition to turbulence
in spatially extended shear flows. Physical Review Letters. 128(1), 014502.
mla: Klotz, Lukasz, et al. “Phase Transition to Turbulence in Spatially Extended
Shear Flows.” Physical Review Letters, vol. 128, no. 1, 014502, American
Physical Society, 2022, doi:10.1103/PhysRevLett.128.014502.
short: L. Klotz, G.M. Lemoult, K. Avila, B. Hof, Physical Review Letters 128 (2022).
date_created: 2022-01-23T23:01:28Z
date_published: 2022-01-05T00:00:00Z
date_updated: 2023-08-02T13:59:19Z
day: '05'
department:
- _id: BjHo
doi: 10.1103/PhysRevLett.128.014502
ec_funded: 1
external_id:
arxiv:
- '2111.14894'
isi:
- '000748271700010'
pmid:
- '35061458'
intvolume: ' 128'
isi: 1
issue: '1'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://arxiv.org/abs/2111.14894
month: '01'
oa: 1
oa_version: Preprint
pmid: 1
project:
- _id: 260C2330-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '754411'
name: ISTplus - Postdoctoral Fellowships
- _id: 25152F3A-B435-11E9-9278-68D0E5697425
call_identifier: FP7
grant_number: '306589'
name: Decoding the complexity of turbulence at its origin
- _id: 238598C6-32DE-11EA-91FC-C7463DDC885E
grant_number: '662960'
name: 'Revisiting the Turbulence Problem Using Statistical Mechanics: Experimental
Studies on Transitional and Turbulent Flows'
publication: Physical Review Letters
publication_identifier:
eissn:
- 1079-7114
issn:
- 0031-9007
publication_status: published
publisher: American Physical Society
quality_controlled: '1'
scopus_import: '1'
status: public
title: Phase transition to turbulence in spatially extended shear flows
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 128
year: '2022'
...
---
_id: '11839'
abstract:
- lang: eng
text: "It is a highly desirable property for deep networks to be robust against\r\nsmall
input changes. One popular way to achieve this property is by designing\r\nnetworks
with a small Lipschitz constant. In this work, we propose a new\r\ntechnique for
constructing such Lipschitz networks that has a number of\r\ndesirable properties:
it can be applied to any linear network layer\r\n(fully-connected or convolutional),
it provides formal guarantees on the\r\nLipschitz constant, it is easy to implement
and efficient to run, and it can be\r\ncombined with any training objective and
optimization method. In fact, our\r\ntechnique is the first one in the literature
that achieves all of these\r\nproperties simultaneously. Our main contribution
is a rescaling-based weight\r\nmatrix parametrization that guarantees each network
layer to have a Lipschitz\r\nconstant of at most 1 and results in the learned
weight matrices to be close to\r\northogonal. Hence we call such layers almost-orthogonal
Lipschitz (AOL).\r\nExperiments and ablation studies in the context of image classification
with\r\ncertified robust accuracy confirm that AOL layers achieve results that
are on\r\npar with most existing methods. Yet, they are simpler to implement and
more\r\nbroadly applicable, because they do not require computationally expensive\r\nmatrix
orthogonalization or inversion steps as part of the network\r\narchitecture. We
provide code at https://github.com/berndprach/AOL."
alternative_title:
- LNCS
article_processing_charge: No
arxiv: 1
author:
- first_name: Bernd
full_name: Prach, Bernd
id: 2D561D42-C427-11E9-89B4-9C1AE6697425
last_name: Prach
- first_name: Christoph
full_name: Lampert, Christoph
id: 40C20FD2-F248-11E8-B48F-1D18A9856A87
last_name: Lampert
orcid: 0000-0001-8622-7887
citation:
ama: 'Prach B, Lampert C. Almost-orthogonal layers for efficient general-purpose
Lipschitz networks. In: Computer Vision – ECCV 2022. Vol 13681. Springer
Nature; 2022:350-365. doi:10.1007/978-3-031-19803-8_21'
apa: 'Prach, B., & Lampert, C. (2022). Almost-orthogonal layers for efficient
general-purpose Lipschitz networks. In Computer Vision – ECCV 2022 (Vol.
13681, pp. 350–365). Tel Aviv, Israel: Springer Nature. https://doi.org/10.1007/978-3-031-19803-8_21'
chicago: Prach, Bernd, and Christoph Lampert. “Almost-Orthogonal Layers for Efficient
General-Purpose Lipschitz Networks.” In Computer Vision – ECCV 2022, 13681:350–65.
Springer Nature, 2022. https://doi.org/10.1007/978-3-031-19803-8_21.
ieee: B. Prach and C. Lampert, “Almost-orthogonal layers for efficient general-purpose
Lipschitz networks,” in Computer Vision – ECCV 2022, Tel Aviv, Israel,
2022, vol. 13681, pp. 350–365.
ista: 'Prach B, Lampert C. 2022. Almost-orthogonal layers for efficient general-purpose
Lipschitz networks. Computer Vision – ECCV 2022. ECCV: European Conference on
Computer Vision, LNCS, vol. 13681, 350–365.'
mla: Prach, Bernd, and Christoph Lampert. “Almost-Orthogonal Layers for Efficient
General-Purpose Lipschitz Networks.” Computer Vision – ECCV 2022, vol.
13681, Springer Nature, 2022, pp. 350–65, doi:10.1007/978-3-031-19803-8_21.
short: B. Prach, C. Lampert, in:, Computer Vision – ECCV 2022, Springer Nature,
2022, pp. 350–365.
conference:
end_date: 2022-10-27
location: Tel Aviv, Israel
name: 'ECCV: European Conference on Computer Vision'
start_date: 2022-10-23
date_created: 2022-08-12T15:09:47Z
date_published: 2022-10-23T00:00:00Z
date_updated: 2023-05-03T08:00:46Z
day: '23'
department:
- _id: GradSch
- _id: ChLa
doi: 10.1007/978-3-031-19803-8_21
external_id:
arxiv:
- '2208.03160'
intvolume: ' 13681'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: ' https://doi.org/10.48550/arXiv.2208.03160'
month: '10'
oa: 1
oa_version: Preprint
page: 350-365
publication: Computer Vision – ECCV 2022
publication_identifier:
eisbn:
- '9783031198038'
isbn:
- '9783031198021'
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
scopus_import: '1'
status: public
title: Almost-orthogonal layers for efficient general-purpose Lipschitz networks
type: conference
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 13681
year: '2022'
...
---
_id: '11841'
abstract:
- lang: eng
text: Primary nucleation is the fundamental event that initiates the conversion
of proteins from their normal physiological forms into pathological amyloid aggregates
associated with the onset and development of disorders including systemic amyloidosis,
as well as the neurodegenerative conditions Alzheimer’s and Parkinson’s diseases.
It has become apparent that the presence of surfaces can dramatically modulate
nucleation. However, the underlying physicochemical parameters governing this
process have been challenging to elucidate, with interfaces in some cases having
been found to accelerate aggregation, while in others they can inhibit the kinetics
of this process. Here we show through kinetic analysis that for three different
fibril-forming proteins, interfaces affect the aggregation reaction mainly through
modulating the primary nucleation step. Moreover, we show through direct measurements
of the Gibbs free energy of adsorption, combined with theory and coarse-grained
computer simulations, that overall nucleation rates are suppressed at high and
at low surface interaction strengths but significantly enhanced at intermediate
strengths, and we verify these regimes experimentally. Taken together, these results
provide a quantitative description of the fundamental process which triggers amyloid
formation and shed light on the key factors that control this process.
acknowledgement: "The research leading to these results has received funding from
the European Research Council (ERC) under the European Union’s Seventh Framework
Programme (FP7/2007-2013) through the ERC grant PhysProt\r\n(agreement 337969).
We are grateful for financial support from the Biotechnology and Biological Sciences
Research Council (BBSRC) (T.P.J.K.), the Newman\r\nFoundation (T.P.J.K.), the Wellcome
Trust (T.P.J.K. and M.V.), Peterhouse College\r\nCambridge (T.C.T.M.), the ERC Starting
Grant (StG) Non-Equilibrium Protein Assembly (NEPA) (A.S.), the Royal Society (A.S.),
the Academy of Medical Sciences\r\n(A.S. and J.K.), and the Cambridge Centre for
Misfolding Diseases (CMD)."
article_number: e2109718119
article_processing_charge: No
article_type: original
author:
- first_name: Zenon
full_name: Toprakcioglu, Zenon
last_name: Toprakcioglu
- first_name: Ayaka
full_name: Kamada, Ayaka
last_name: Kamada
- first_name: Thomas C.T.
full_name: Michaels, Thomas C.T.
last_name: Michaels
- first_name: Mengqi
full_name: Xie, Mengqi
last_name: Xie
- first_name: Johannes
full_name: Krausser, Johannes
last_name: Krausser
- first_name: Jiapeng
full_name: Wei, Jiapeng
last_name: Wei
- first_name: Anđela
full_name: Šarić, Anđela
id: bf63d406-f056-11eb-b41d-f263a6566d8b
last_name: Šarić
orcid: 0000-0002-7854-2139
- first_name: Michele
full_name: Vendruscolo, Michele
last_name: Vendruscolo
- first_name: Tuomas P.J.
full_name: Knowles, Tuomas P.J.
last_name: Knowles
citation:
ama: Toprakcioglu Z, Kamada A, Michaels TCT, et al. Adsorption free energy predicts
amyloid protein nucleation rates. Proceedings of the National Academy of Sciences
of the United States of America. 2022;119(31). doi:10.1073/pnas.2109718119
apa: Toprakcioglu, Z., Kamada, A., Michaels, T. C. T., Xie, M., Krausser, J., Wei,
J., … Knowles, T. P. J. (2022). Adsorption free energy predicts amyloid protein
nucleation rates. Proceedings of the National Academy of Sciences of the United
States of America. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.2109718119
chicago: Toprakcioglu, Zenon, Ayaka Kamada, Thomas C.T. Michaels, Mengqi Xie, Johannes
Krausser, Jiapeng Wei, Anđela Šarić, Michele Vendruscolo, and Tuomas P.J. Knowles.
“Adsorption Free Energy Predicts Amyloid Protein Nucleation Rates.” Proceedings
of the National Academy of Sciences of the United States of America. Proceedings
of the National Academy of Sciences, 2022. https://doi.org/10.1073/pnas.2109718119.
ieee: Z. Toprakcioglu et al., “Adsorption free energy predicts amyloid protein
nucleation rates,” Proceedings of the National Academy of Sciences of the United
States of America, vol. 119, no. 31. Proceedings of the National Academy of
Sciences, 2022.
ista: Toprakcioglu Z, Kamada A, Michaels TCT, Xie M, Krausser J, Wei J, Šarić A,
Vendruscolo M, Knowles TPJ. 2022. Adsorption free energy predicts amyloid protein
nucleation rates. Proceedings of the National Academy of Sciences of the United
States of America. 119(31), e2109718119.
mla: Toprakcioglu, Zenon, et al. “Adsorption Free Energy Predicts Amyloid Protein
Nucleation Rates.” Proceedings of the National Academy of Sciences of the United
States of America, vol. 119, no. 31, e2109718119, Proceedings of the National
Academy of Sciences, 2022, doi:10.1073/pnas.2109718119.
short: Z. Toprakcioglu, A. Kamada, T.C.T. Michaels, M. Xie, J. Krausser, J. Wei,
A. Šarić, M. Vendruscolo, T.P.J. Knowles, Proceedings of the National Academy
of Sciences of the United States of America 119 (2022).
date_created: 2022-08-14T22:01:45Z
date_published: 2022-07-28T00:00:00Z
date_updated: 2023-10-04T09:06:52Z
day: '28'
ddc:
- '570'
department:
- _id: AnSa
doi: 10.1073/pnas.2109718119
ec_funded: 1
external_id:
isi:
- '000903753500002'
file:
- access_level: open_access
checksum: 0fe3878896cbeb6c44e29222ec2f336a
content_type: application/pdf
creator: dernst
date_created: 2023-10-04T09:05:44Z
date_updated: 2023-10-04T09:05:44Z
file_id: '14386'
file_name: 2022_PNAS_Toprakcioglu.pdf
file_size: 2476021
relation: main_file
success: 1
file_date_updated: 2023-10-04T09:05:44Z
has_accepted_license: '1'
intvolume: ' 119'
isi: 1
issue: '31'
language:
- iso: eng
month: '07'
oa: 1
oa_version: Published Version
project:
- _id: eba2549b-77a9-11ec-83b8-a81e493eae4e
call_identifier: H2020
grant_number: '802960'
name: 'Non-Equilibrium Protein Assembly: from Building Blocks to Biological Machines'
publication: Proceedings of the National Academy of Sciences of the United States
of America
publication_identifier:
eissn:
- 1091-6490
issn:
- 0027-8424
publication_status: published
publisher: Proceedings of the National Academy of Sciences
quality_controlled: '1'
scopus_import: '1'
status: public
title: Adsorption free energy predicts amyloid protein nucleation rates
tmp:
image: /images/cc_by_nc_nd.png
legal_code_url: https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode
name: Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
(CC BY-NC-ND 4.0)
short: CC BY-NC-ND (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 119
year: '2022'
...
---
_id: '11842'
abstract:
- lang: eng
text: We consider the flow of two viscous and incompressible fluids within a bounded
domain modeled by means of a two-phase Navier–Stokes system. The two fluids are
assumed to be immiscible, meaning that they are separated by an interface. With
respect to the motion of the interface, we consider pure transport by the fluid
flow. Along the boundary of the domain, a complete slip boundary condition for
the fluid velocities and a constant ninety degree contact angle condition for
the interface are assumed. In the present work, we devise for the resulting evolution
problem a suitable weak solution concept based on the framework of varifolds and
establish as the main result a weak-strong uniqueness principle in 2D. The proof
is based on a relative entropy argument and requires a non-trivial further development
of ideas from the recent work of Fischer and the first author (Arch. Ration. Mech.
Anal. 236, 2020) to incorporate the contact angle condition. To focus on the effects
of the necessarily singular geometry of the evolving fluid domains, we work for
simplicity in the regime of same viscosities for the two fluids.
acknowledgement: The authors warmly thank their former resp. current PhD advisor Julian
Fischer for the suggestion of this problem and for valuable initial discussions
on the subjects of this paper. This project has received funding from the European
Research Council (ERC) under the European Union’s Horizon 2020 research and innovation
programme (grant agreement No 948819) , and from the Deutsche Forschungsgemeinschaft
(DFG, German Research Foundation) under Germany’s Excellence Strategy – EXC-2047/1
– 390685813.
article_number: '93'
article_processing_charge: No
article_type: original
arxiv: 1
author:
- first_name: Sebastian
full_name: Hensel, Sebastian
id: 4D23B7DA-F248-11E8-B48F-1D18A9856A87
last_name: Hensel
orcid: 0000-0001-7252-8072
- first_name: Alice
full_name: Marveggio, Alice
id: 25647992-AA84-11E9-9D75-8427E6697425
last_name: Marveggio
citation:
ama: Hensel S, Marveggio A. Weak-strong uniqueness for the Navier–Stokes equation
for two fluids with ninety degree contact angle and same viscosities. Journal
of Mathematical Fluid Mechanics. 2022;24(3). doi:10.1007/s00021-022-00722-2
apa: Hensel, S., & Marveggio, A. (2022). Weak-strong uniqueness for the Navier–Stokes
equation for two fluids with ninety degree contact angle and same viscosities.
Journal of Mathematical Fluid Mechanics. Springer Nature. https://doi.org/10.1007/s00021-022-00722-2
chicago: Hensel, Sebastian, and Alice Marveggio. “Weak-Strong Uniqueness for the
Navier–Stokes Equation for Two Fluids with Ninety Degree Contact Angle and Same
Viscosities.” Journal of Mathematical Fluid Mechanics. Springer Nature,
2022. https://doi.org/10.1007/s00021-022-00722-2.
ieee: S. Hensel and A. Marveggio, “Weak-strong uniqueness for the Navier–Stokes
equation for two fluids with ninety degree contact angle and same viscosities,”
Journal of Mathematical Fluid Mechanics, vol. 24, no. 3. Springer Nature,
2022.
ista: Hensel S, Marveggio A. 2022. Weak-strong uniqueness for the Navier–Stokes
equation for two fluids with ninety degree contact angle and same viscosities.
Journal of Mathematical Fluid Mechanics. 24(3), 93.
mla: Hensel, Sebastian, and Alice Marveggio. “Weak-Strong Uniqueness for the Navier–Stokes
Equation for Two Fluids with Ninety Degree Contact Angle and Same Viscosities.”
Journal of Mathematical Fluid Mechanics, vol. 24, no. 3, 93, Springer Nature,
2022, doi:10.1007/s00021-022-00722-2.
short: S. Hensel, A. Marveggio, Journal of Mathematical Fluid Mechanics 24 (2022).
date_created: 2022-08-14T22:01:45Z
date_published: 2022-08-01T00:00:00Z
date_updated: 2023-11-30T13:25:02Z
day: '01'
ddc:
- '510'
department:
- _id: JuFi
doi: 10.1007/s00021-022-00722-2
ec_funded: 1
external_id:
arxiv:
- '2112.11154'
isi:
- '000834834300001'
file:
- access_level: open_access
checksum: 75c5f286300e6f0539cf57b4dba108d5
content_type: application/pdf
creator: cchlebak
date_created: 2022-08-16T06:55:22Z
date_updated: 2022-08-16T06:55:22Z
file_id: '11848'
file_name: 2022_JMathFluidMech_Hensel.pdf
file_size: 2045570
relation: main_file
success: 1
file_date_updated: 2022-08-16T06:55:22Z
has_accepted_license: '1'
intvolume: ' 24'
isi: 1
issue: '3'
language:
- iso: eng
month: '08'
oa: 1
oa_version: Published Version
project:
- _id: 0aa76401-070f-11eb-9043-b5bb049fa26d
call_identifier: H2020
grant_number: '948819'
name: Bridging Scales in Random Materials
publication: Journal of Mathematical Fluid Mechanics
publication_identifier:
eissn:
- 1422-6952
issn:
- 1422-6928
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
related_material:
record:
- id: '14587'
relation: dissertation_contains
status: public
scopus_import: '1'
status: public
title: Weak-strong uniqueness for the Navier–Stokes equation for two fluids with ninety
degree contact angle and same viscosities
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 24
year: '2022'
...
---
_id: '11843'
abstract:
- lang: eng
text: A key attribute of persistent or recurring bacterial infections is the ability
of the pathogen to evade the host’s immune response. Many Enterobacteriaceae express
type 1 pili, a pre-adapted virulence trait, to invade host epithelial cells and
establish persistent infections. However, the molecular mechanisms and strategies
by which bacteria actively circumvent the immune response of the host remain poorly
understood. Here, we identified CD14, the major co-receptor for lipopolysaccharide
detection, on mouse dendritic cells (DCs) as a binding partner of FimH, the protein
located at the tip of the type 1 pilus of Escherichia coli. The FimH amino acids
involved in CD14 binding are highly conserved across pathogenic and non-pathogenic
strains. Binding of the pathogenic strain CFT073 to CD14 reduced DC migration
by overactivation of integrins and blunted expression of co-stimulatory molecules
by overactivating the NFAT (nuclear factor of activated T-cells) pathway, both
rate-limiting factors of T cell activation. This response was binary at the single-cell
level, but averaged in larger populations exposed to both piliated and non-piliated
pathogens, presumably via the exchange of immunomodulatory cytokines. While defining
an active molecular mechanism of immune evasion by pathogens, the interaction
between FimH and CD14 represents a potential target to interfere with persistent
and recurrent infections, such as urinary tract infections or Crohn’s disease.
acknowledged_ssus:
- _id: Bio
- _id: PreCl
- _id: EM-Fac
acknowledgement: We thank Ulrich Dobrindt for providing UPEC strains CFT073, UTI89,
and 536, Frank Assen, Vlad Gavra, Maximilian Götz, Bor Kavčič, Jonna Alanko, and
Eva Kiermaier for help with experiments and Robert Hauschild, Julian Stopp, and
Saren Tasciyan for help with data analysis. We thank the IST Austria Scientific
Service Units, especially the Bioimaging facility, the Preclinical facility and
the Electron microscopy facility for technical support, Jakob Wallner and all members
of the Guet and Sixt lab for fruitful discussions and Daria Siekhaus for critically
reading the manuscript. This work was supported by grants from the Austrian Research
Promotion Agency (FEMtech 868984) to IG, the European Research Council (CoG 724373),
and the Austrian Science Fund (FWF P29911) to MS.
article_number: e78995
article_processing_charge: Yes
article_type: original
author:
- first_name: Kathrin
full_name: Tomasek, Kathrin
id: 3AEC8556-F248-11E8-B48F-1D18A9856A87
last_name: Tomasek
- first_name: Alexander F
full_name: Leithner, Alexander F
id: 3B1B77E4-F248-11E8-B48F-1D18A9856A87
last_name: Leithner
- first_name: Ivana
full_name: Glatzová, Ivana
id: 727b3c7d-4939-11ec-89b3-b9b0750ab74d
last_name: Glatzová
- first_name: Michael S.
full_name: Lukesch, Michael S.
last_name: Lukesch
- first_name: Calin C
full_name: Guet, Calin C
id: 47F8433E-F248-11E8-B48F-1D18A9856A87
last_name: Guet
orcid: 0000-0001-6220-2052
- first_name: Michael K
full_name: Sixt, Michael K
id: 41E9FBEA-F248-11E8-B48F-1D18A9856A87
last_name: Sixt
orcid: 0000-0002-6620-9179
citation:
ama: Tomasek K, Leithner AF, Glatzová I, Lukesch MS, Guet CC, Sixt MK. Type 1 piliated
uropathogenic Escherichia coli hijack the host immune response by binding to CD14.
eLife. 2022;11. doi:10.7554/eLife.78995
apa: Tomasek, K., Leithner, A. F., Glatzová, I., Lukesch, M. S., Guet, C. C., &
Sixt, M. K. (2022). Type 1 piliated uropathogenic Escherichia coli hijack the
host immune response by binding to CD14. ELife. eLife Sciences Publications.
https://doi.org/10.7554/eLife.78995
chicago: Tomasek, Kathrin, Alexander F Leithner, Ivana Glatzová, Michael S. Lukesch,
Calin C Guet, and Michael K Sixt. “Type 1 Piliated Uropathogenic Escherichia Coli
Hijack the Host Immune Response by Binding to CD14.” ELife. eLife Sciences
Publications, 2022. https://doi.org/10.7554/eLife.78995.
ieee: K. Tomasek, A. F. Leithner, I. Glatzová, M. S. Lukesch, C. C. Guet, and M.
K. Sixt, “Type 1 piliated uropathogenic Escherichia coli hijack the host immune
response by binding to CD14,” eLife, vol. 11. eLife Sciences Publications,
2022.
ista: Tomasek K, Leithner AF, Glatzová I, Lukesch MS, Guet CC, Sixt MK. 2022. Type
1 piliated uropathogenic Escherichia coli hijack the host immune response by binding
to CD14. eLife. 11, e78995.
mla: Tomasek, Kathrin, et al. “Type 1 Piliated Uropathogenic Escherichia Coli Hijack
the Host Immune Response by Binding to CD14.” ELife, vol. 11, e78995, eLife
Sciences Publications, 2022, doi:10.7554/eLife.78995.
short: K. Tomasek, A.F. Leithner, I. Glatzová, M.S. Lukesch, C.C. Guet, M.K. Sixt,
ELife 11 (2022).
date_created: 2022-08-14T22:01:46Z
date_published: 2022-07-26T00:00:00Z
date_updated: 2023-08-03T12:54:21Z
day: '26'
ddc:
- '570'
department:
- _id: MiSi
- _id: CaGu
doi: 10.7554/eLife.78995
ec_funded: 1
external_id:
isi:
- '000838410200001'
file:
- access_level: open_access
checksum: 002a3c7c7ea5caa9af9cfbea308f6ea4
content_type: application/pdf
creator: cchlebak
date_created: 2022-08-16T08:57:37Z
date_updated: 2022-08-16T08:57:37Z
file_id: '11861'
file_name: 2022_eLife_Tomasek.pdf
file_size: 2057577
relation: main_file
success: 1
file_date_updated: 2022-08-16T08:57:37Z
has_accepted_license: '1'
intvolume: ' 11'
isi: 1
language:
- iso: eng
month: '07'
oa: 1
oa_version: Published Version
project:
- _id: 25FE9508-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '724373'
name: Cellular navigation along spatial gradients
- _id: 26018E70-B435-11E9-9278-68D0E5697425
call_identifier: FWF
grant_number: P29911
name: Mechanical adaptation of lamellipodial actin
publication: eLife
publication_identifier:
eissn:
- 2050-084X
publication_status: published
publisher: eLife Sciences Publications
quality_controlled: '1'
related_material:
record:
- id: '10316'
relation: earlier_version
status: public
scopus_import: '1'
status: public
title: Type 1 piliated uropathogenic Escherichia coli hijack the host immune response
by binding to CD14
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 11
year: '2022'
...
---
_id: '11844'
abstract:
- lang: eng
text: "In the stochastic population protocol model, we are given a connected graph
with n nodes, and in every time step, a scheduler samples an edge of the graph
uniformly at random and the nodes connected by this edge interact. A fundamental
task in this model is stable leader election, in which all nodes start in an identical
state and the aim is to reach a configuration in which (1) exactly one node is
elected as leader and (2) this node remains as the unique leader no matter what
sequence of interactions follows. On cliques, the complexity of this problem has
recently been settled: time-optimal protocols stabilize in Θ(n log n) expected
steps using Θ(log log n) states, whereas protocols that use O(1) states require
Θ(n2) expected steps.\r\n\r\nIn this work, we investigate the complexity of stable
leader election on general graphs. We provide the first non-trivial time lower
bounds for leader election on general graphs, showing that, when moving beyond
cliques, the complexity landscape of leader election becomes very diverse: the
time required to elect a leader can range from O(1) to Θ(n3) expected steps. On
the upper bound side, we first observe that there exists a protocol that is time-optimal
on many graph families, but uses polynomially-many states. In contrast, we give
a near-time-optimal protocol that uses only O(log2n) states that is at most a
factor log n slower. Finally, we show that the constant-state protocol of Beauquier
et al. [OPODIS 2013] is at most a factor n log n slower than the fast polynomial-state
protocol. Moreover, among constant-state protocols, this protocol has near-optimal
average case complexity on dense random graphs."
acknowledgement: We thank the anonymous reviewers for their helpful comments. We gratefully
acknowledge funding from the European Research Council (ERC) under the European
Union’s Horizon 2020 research and innovation programme (grant agreement No 805223
ScaleML).
article_processing_charge: Yes (via OA deal)
arxiv: 1
author:
- first_name: Dan-Adrian
full_name: Alistarh, Dan-Adrian
id: 4A899BFC-F248-11E8-B48F-1D18A9856A87
last_name: Alistarh
orcid: 0000-0003-3650-940X
- first_name: Joel
full_name: Rybicki, Joel
id: 334EFD2E-F248-11E8-B48F-1D18A9856A87
last_name: Rybicki
orcid: 0000-0002-6432-6646
- first_name: Sasha
full_name: Voitovych, Sasha
last_name: Voitovych
citation:
ama: 'Alistarh D-A, Rybicki J, Voitovych S. Near-optimal leader election in population
protocols on graphs. In: Proceedings of the Annual ACM Symposium on Principles
of Distributed Computing. Association for Computing Machinery; 2022:246-256.
doi:10.1145/3519270.3538435'
apa: 'Alistarh, D.-A., Rybicki, J., & Voitovych, S. (2022). Near-optimal leader
election in population protocols on graphs. In Proceedings of the Annual ACM
Symposium on Principles of Distributed Computing (pp. 246–256). Salerno, Italy:
Association for Computing Machinery. https://doi.org/10.1145/3519270.3538435'
chicago: Alistarh, Dan-Adrian, Joel Rybicki, and Sasha Voitovych. “Near-Optimal
Leader Election in Population Protocols on Graphs.” In Proceedings of the Annual
ACM Symposium on Principles of Distributed Computing, 246–56. Association
for Computing Machinery, 2022. https://doi.org/10.1145/3519270.3538435.
ieee: D.-A. Alistarh, J. Rybicki, and S. Voitovych, “Near-optimal leader election
in population protocols on graphs,” in Proceedings of the Annual ACM Symposium
on Principles of Distributed Computing, Salerno, Italy, 2022, pp. 246–256.
ista: 'Alistarh D-A, Rybicki J, Voitovych S. 2022. Near-optimal leader election
in population protocols on graphs. Proceedings of the Annual ACM Symposium on
Principles of Distributed Computing. PODC: Symposium on Principles of Distributed
Computing, 246–256.'
mla: Alistarh, Dan-Adrian, et al. “Near-Optimal Leader Election in Population Protocols
on Graphs.” Proceedings of the Annual ACM Symposium on Principles of Distributed
Computing, Association for Computing Machinery, 2022, pp. 246–56, doi:10.1145/3519270.3538435.
short: D.-A. Alistarh, J. Rybicki, S. Voitovych, in:, Proceedings of the Annual
ACM Symposium on Principles of Distributed Computing, Association for Computing
Machinery, 2022, pp. 246–256.
conference:
end_date: 2022-07-29
location: Salerno, Italy
name: 'PODC: Symposium on Principles of Distributed Computing'
start_date: 2022-07-25
date_created: 2022-08-14T22:01:46Z
date_published: 2022-07-21T00:00:00Z
date_updated: 2023-06-14T12:06:01Z
day: '21'
ddc:
- '000'
department:
- _id: DaAl
doi: 10.1145/3519270.3538435
ec_funded: 1
external_id:
arxiv:
- '2205.12597'
file:
- access_level: open_access
checksum: 4c6b29172b8e355b4fbc364a2e0827b2
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creator: cchlebak
date_created: 2022-08-16T08:05:15Z
date_updated: 2022-08-16T08:05:15Z
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file_name: 2022_PODC_Alistarh.pdf
file_size: 1593474
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success: 1
file_date_updated: 2022-08-16T08:05:15Z
has_accepted_license: '1'
language:
- iso: eng
month: '07'
oa: 1
oa_version: Published Version
page: 246-256
project:
- _id: 268A44D6-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '805223'
name: Elastic Coordination for Scalable Machine Learning
publication: Proceedings of the Annual ACM Symposium on Principles of Distributed
Computing
publication_identifier:
isbn:
- '9781450392624'
publication_status: published
publisher: Association for Computing Machinery
quality_controlled: '1'
scopus_import: '1'
status: public
title: Near-optimal leader election in population protocols on graphs
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: conference
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '2022'
...
---
_id: '11858'
abstract:
- lang: eng
text: "This paper is a continuation of Part I of this project, where we developed
a new local well-posedness theory for nonlinear stochastic PDEs with Gaussian
noise. In the current Part II we consider blow-up criteria and regularization
phenomena. As in Part I we can allow nonlinearities with polynomial growth and
rough initial values from critical spaces. In the first main result we obtain
several new blow-up criteria for quasi- and semilinear stochastic evolution equations.
In particular, for semilinear equations we obtain a Serrin type blow-up criterium,
which extends a recent result of Prüss–Simonett–Wilke (J Differ Equ 264(3):2028–2074,
2018) to the stochastic setting. Blow-up criteria can be used to prove global
well-posedness for SPDEs. As in Part I, maximal regularity techniques and weights
in time play a central role in the proofs. Our second contribution is a new method
to bootstrap Sobolev and Hölder regularity in time and space, which does not require
smoothness of the initial data. The blow-up criteria are at the basis of these
new methods. Moreover, in applications the bootstrap results can be combined with
our blow-up criteria, to obtain efficient ways to prove global existence. This
gives new results even in classical \U0001D43F2-settings, which we illustrate
for a concrete SPDE. In future works in preparation we apply the results of the
current paper to obtain global well-posedness results and regularity for several
concrete SPDEs. These include stochastic Navier–Stokes equations, reaction– diffusion
equations and the Allen–Cahn equation. Our setting allows to put these SPDEs into
a more flexible framework, where less restrictions on the nonlinearities are needed,
and we are able to treat rough initial values from critical spaces. Moreover,
we will obtain higher-order regularity results."
acknowledgement: "The authors thank Emiel Lorist for helpful comments. The authors
thank the anonymous referees for their helpful remarks to improve the presentation.\r\nOpen
access funding provided by Institute of Science and Technology (IST Austria)."
article_number: '56'
article_processing_charge: Yes (via OA deal)
article_type: original
author:
- first_name: Antonio
full_name: Agresti, Antonio
id: 673cd0cc-9b9a-11eb-b144-88f30e1fbb72
last_name: Agresti
orcid: 0000-0002-9573-2962
- first_name: Mark
full_name: Veraar, Mark
last_name: Veraar
citation:
ama: Agresti A, Veraar M. Nonlinear parabolic stochastic evolution equations in
critical spaces part II. Journal of Evolution Equations. 2022;22(2). doi:10.1007/s00028-022-00786-7
apa: Agresti, A., & Veraar, M. (2022). Nonlinear parabolic stochastic evolution
equations in critical spaces part II. Journal of Evolution Equations. Springer
Nature. https://doi.org/10.1007/s00028-022-00786-7
chicago: Agresti, Antonio, and Mark Veraar. “Nonlinear Parabolic Stochastic Evolution
Equations in Critical Spaces Part II.” Journal of Evolution Equations.
Springer Nature, 2022. https://doi.org/10.1007/s00028-022-00786-7.
ieee: A. Agresti and M. Veraar, “Nonlinear parabolic stochastic evolution equations
in critical spaces part II,” Journal of Evolution Equations, vol. 22, no.
2. Springer Nature, 2022.
ista: Agresti A, Veraar M. 2022. Nonlinear parabolic stochastic evolution equations
in critical spaces part II. Journal of Evolution Equations. 22(2), 56.
mla: Agresti, Antonio, and Mark Veraar. “Nonlinear Parabolic Stochastic Evolution
Equations in Critical Spaces Part II.” Journal of Evolution Equations,
vol. 22, no. 2, 56, Springer Nature, 2022, doi:10.1007/s00028-022-00786-7.
short: A. Agresti, M. Veraar, Journal of Evolution Equations 22 (2022).
date_created: 2022-08-16T08:39:43Z
date_published: 2022-06-01T00:00:00Z
date_updated: 2023-08-03T12:53:51Z
day: '01'
ddc:
- '510'
department:
- _id: JuFi
doi: 10.1007/s00028-022-00786-7
external_id:
isi:
- '000809108500001'
file:
- access_level: open_access
checksum: 59b99d1b48b6bd40983e7ce298524a21
content_type: application/pdf
creator: kschuh
date_created: 2022-08-16T08:52:46Z
date_updated: 2022-08-16T08:52:46Z
file_id: '11862'
file_name: 2022_Journal of Evolution Equations_Agresti.pdf
file_size: 1758371
relation: main_file
success: 1
file_date_updated: 2022-08-16T08:52:46Z
has_accepted_license: '1'
intvolume: ' 22'
isi: 1
issue: '2'
keyword:
- Mathematics (miscellaneous)
language:
- iso: eng
month: '06'
oa: 1
oa_version: Published Version
publication: Journal of Evolution Equations
publication_identifier:
eissn:
- 1424-3202
issn:
- 1424-3199
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
scopus_import: '1'
status: public
title: Nonlinear parabolic stochastic evolution equations in critical spaces part
II
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 22
year: '2022'
...
---
_id: '11879'
abstract:
- lang: eng
text: "As the overall global mean surface temperature is increasing due to climate
change, plant\r\nadaptation to those stressful conditions is of utmost importance
for their survival. Plants are\r\nsessile organisms, thus to compensate for their
lack of mobility, they evolved a variety of\r\nmechanisms enabling them to flexibly
adjust their physiological, growth and developmental\r\nprocesses to fluctuating
temperatures and to survive in harsh environments. While these unique\r\nadaptation
abilities provide an important evolutionary advantage, overall modulation of plant\r\ngrowth
and developmental program due to non-optimal temperature negatively affects biomass\r\nproduction,
crop productivity or sensitivity to pathogens. Thus, understanding molecular\r\nprocesses
underlying plant adaptation to increased temperature can provide important\r\nresources
for breeding strategies to ensure sufficient agricultural food production.\r\nAn
increase in ambient temperature by a few degrees leads to profound changes in
organ growth\r\nincluding enhanced hypocotyl elongation, expansion of petioles,
hyponastic growth of leaves and\r\ncotyledons, collectively named thermomorphogenesis
(Casal & Balasubramanian, 2019). Auxin,\r\none of the best-studied growth hormones,
plays an essential role in this process by direct\r\nactivation of transcriptional
and non-transcriptional processes resulting in elongation growth\r\n(Majda & Robert,
2018).To modulate hypocotyl growth in response to high ambient temperature\r\n(hAT),
auxin needs to be redistributed accordingly. PINs, auxin efflux transporters,
are key\r\ncomponents of the polar auxin transport (PAT) machinery, which controls
the amount and\r\ndirection of auxin translocated in the plant tissues and organs(Adamowski
& Friml, 2015). Hence,\r\nPIN-mediated transport is tightly linked with thermo-morphogenesis,
and interference with PAT\r\nthrough either chemical or genetic means dramatically
affecting the adaptive responses to hAT.\r\nIntriguingly, despite the key role
of PIN mediated transport in growth response to hAT, whether\r\nand how PINs at
the level of expression adapt to fluctuation in temperature is scarcely\r\nunderstood.\r\nWith
genetic, molecular and advanced bio-imaging approaches, we demonstrate the role
of PIN\r\nauxin transporters in the regulation of hypocotyl growth in response
to hAT. We show that via\r\nadjustment of PIN3, PIN4 and PIN7 expression in cotyledons
and hypocotyls, auxin distribution is modulated thereby determining elongation
pattern of epidermal cells at hAT. Furthermore, we\r\nidentified three Zinc-Finger
(ZF) transcription factors as novel molecular components of the\r\nthermo-regulatory
network, which through negative regulation of PIN transcription adjust the\r\ntransport
of auxin at hAT. Our results suggest that the ZF-PIN module might be a part of
the\r\nnegative feedback loop attenuating the activity of the thermo-sensing pathway
to restrain\r\nexaggerated growth and developmental responses to hAT."
acknowledged_ssus:
- _id: Bio
- _id: LifeSc
- _id: SSU
acknowledgement: I would like to acknowledge ISTA and all the people from the Scientific
Service Units and at ISTA, in particular Dorota Jaworska for excellent technical
and scientific support as well as ÖAW for funding my research for over 3 years (DOC
ÖAW Fellowship PR1022OEAW02).
alternative_title:
- ISTA Thesis
article_processing_charge: No
author:
- first_name: Christina
full_name: Artner, Christina
id: 45DF286A-F248-11E8-B48F-1D18A9856A87
last_name: Artner
citation:
ama: Artner C. Modulation of auxin transport via ZF proteins adjust plant response
to high ambient temperature. 2022. doi:10.15479/at:ista:11879
apa: Artner, C. (2022). Modulation of auxin transport via ZF proteins adjust
plant response to high ambient temperature. Institute of Science and Technology
Austria. https://doi.org/10.15479/at:ista:11879
chicago: Artner, Christina. “Modulation of Auxin Transport via ZF Proteins Adjust
Plant Response to High Ambient Temperature.” Institute of Science and Technology
Austria, 2022. https://doi.org/10.15479/at:ista:11879.
ieee: C. Artner, “Modulation of auxin transport via ZF proteins adjust plant response
to high ambient temperature,” Institute of Science and Technology Austria, 2022.
ista: Artner C. 2022. Modulation of auxin transport via ZF proteins adjust plant
response to high ambient temperature. Institute of Science and Technology Austria.
mla: Artner, Christina. Modulation of Auxin Transport via ZF Proteins Adjust
Plant Response to High Ambient Temperature. Institute of Science and Technology
Austria, 2022, doi:10.15479/at:ista:11879.
short: C. Artner, Modulation of Auxin Transport via ZF Proteins Adjust Plant Response
to High Ambient Temperature, Institute of Science and Technology Austria, 2022.
date_created: 2022-08-17T07:58:53Z
date_published: 2022-08-17T00:00:00Z
date_updated: 2023-09-09T22:30:04Z
day: '17'
ddc:
- '580'
degree_awarded: PhD
department:
- _id: GradSch
- _id: EvBe
doi: 10.15479/at:ista:11879
file:
- access_level: open_access
checksum: a2c2fdc28002538840490bfa6a08b2cb
content_type: application/pdf
creator: cartner
date_created: 2022-08-17T12:08:49Z
date_updated: 2023-09-09T22:30:03Z
embargo: 2023-09-08
file_id: '11907'
file_name: ChristinaArtner_PhD_Thesis_2022.pdf
file_size: 11113608
relation: main_file
- access_level: closed
checksum: 66b461c074b815fbe63481b3f46a9f43
content_type: application/octet-stream
creator: cartner
date_created: 2022-08-17T12:08:59Z
date_updated: 2023-09-09T22:30:03Z
embargo_to: open_access
file_id: '11908'
file_name: ChristinaArtner_PhD_Thesis_2022.7z
file_size: 19097730
relation: source_file
file_date_updated: 2023-09-09T22:30:03Z
has_accepted_license: '1'
keyword:
- high ambient temperature
- auxin
- PINs
- Zinc-Finger proteins
- thermomorphogenesis
- stress
language:
- iso: eng
month: '08'
oa: 1
oa_version: Published Version
page: '128'
project:
- _id: 2685A872-B435-11E9-9278-68D0E5697425
name: Hormonal regulation of plant adaptive responses to environmental signals
publication_identifier:
isbn:
- 978-3-99078-022-0
issn:
- 2663-337X
publication_status: published
publisher: Institute of Science and Technology Austria
status: public
supervisor:
- first_name: Eva
full_name: Benková, Eva
id: 38F4F166-F248-11E8-B48F-1D18A9856A87
last_name: Benková
orcid: 0000-0002-8510-9739
title: Modulation of auxin transport via ZF proteins adjust plant response to high
ambient temperature
type: dissertation
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '2022'
...
---
_id: '11916'
abstract:
- lang: eng
text: A domain is called Kac regular for a quadratic form on L2 if every functions
vanishing almost everywhere outside the domain can be approximated in form norm
by functions with compact support in the domain. It is shown that this notion
is stable under domination of quadratic forms. As applications measure perturbations
of quasi-regular Dirichlet forms, Cheeger energies on metric measure spaces and
Schrödinger operators on manifolds are studied. Along the way a characterization
of the Sobolev space with Dirichlet boundary conditions on domains in infinitesimally
Riemannian metric measure spaces is obtained.
acknowledgement: "The author was supported by the German Academic Scholarship Foundation
(Studienstiftung des deutschen Volkes) and by the German Research Foundation (DFG)
via RTG 1523/2. The author would like to thank Daniel Lenz for his support and encouragement
during the author’s ongoing graduate studies and him as well as Marcel Schmidt for
fruitful discussions on domination of quadratic forms. He wants to thank Batu Güneysu
and Peter Stollmann for valuable comments on a preliminary version of this article.
He would also like to thank the organizers of the conference Analysis and Geometry
on Graphs and Manifolds in Potsdam, where the initial motivation of this article
was conceived, and the organizers of the intense activity period Metric Measure
Spaces and Ricci Curvature at MPIM in Bonn, where this work was finished.\r\nOpen
access funding provided by Institute of Science and Technology (IST Austria)."
article_number: '38'
article_processing_charge: Yes (via OA deal)
article_type: original
author:
- first_name: Melchior
full_name: Wirth, Melchior
id: 88644358-0A0E-11EA-8FA5-49A33DDC885E
last_name: Wirth
orcid: 0000-0002-0519-4241
citation:
ama: Wirth M. Kac regularity and domination of quadratic forms. Advances in Operator
Theory. 2022;7(3). doi:10.1007/s43036-022-00199-w
apa: Wirth, M. (2022). Kac regularity and domination of quadratic forms. Advances
in Operator Theory. Springer Nature. https://doi.org/10.1007/s43036-022-00199-w
chicago: Wirth, Melchior. “Kac Regularity and Domination of Quadratic Forms.” Advances
in Operator Theory. Springer Nature, 2022. https://doi.org/10.1007/s43036-022-00199-w.
ieee: M. Wirth, “Kac regularity and domination of quadratic forms,” Advances
in Operator Theory, vol. 7, no. 3. Springer Nature, 2022.
ista: Wirth M. 2022. Kac regularity and domination of quadratic forms. Advances
in Operator Theory. 7(3), 38.
mla: Wirth, Melchior. “Kac Regularity and Domination of Quadratic Forms.” Advances
in Operator Theory, vol. 7, no. 3, 38, Springer Nature, 2022, doi:10.1007/s43036-022-00199-w.
short: M. Wirth, Advances in Operator Theory 7 (2022).
date_created: 2022-08-18T07:22:24Z
date_published: 2022-07-01T00:00:00Z
date_updated: 2023-02-21T10:08:07Z
day: '01'
ddc:
- '510'
department:
- _id: JaMa
doi: 10.1007/s43036-022-00199-w
file:
- access_level: open_access
checksum: 913474844a1b38264fb710746d5e2e98
content_type: application/pdf
creator: dernst
date_created: 2022-08-18T08:02:34Z
date_updated: 2022-08-18T08:02:34Z
file_id: '11921'
file_name: 2022_AdvancesOperatorTheory_Wirth.pdf
file_size: 389060
relation: main_file
success: 1
file_date_updated: 2022-08-18T08:02:34Z
has_accepted_license: '1'
intvolume: ' 7'
issue: '3'
keyword:
- Algebra and Number Theory
- Analysis
language:
- iso: eng
month: '07'
oa: 1
oa_version: Published Version
publication: Advances in Operator Theory
publication_identifier:
eissn:
- 2538-225X
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
scopus_import: '1'
status: public
title: Kac regularity and domination of quadratic forms
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 7
year: '2022'
...
---
_id: '11917'
abstract:
- lang: eng
text: We study the many-body dynamics of an initially factorized bosonic wave function
in the mean-field regime. We prove large deviation estimates for the fluctuations
around the condensate. We derive an upper bound extending a recent result to more
general interactions. Furthermore, we derive a new lower bound which agrees with
the upper bound in leading order.
acknowledgement: "The authors thank Gérard Ben Arous for pointing out the question
of a lower bound. Funding from the European Union’s Horizon 2020 research and innovation
programme under the ERC Grant Agreement No. 694227 (R.S.) and under the Marie Skłodowska-Curie
Grant Agreement No. 754411 (S.R.) is gratefully acknowledged.\r\nOpen access funding
provided by IST Austria."
article_number: '9'
article_processing_charge: Yes (via OA deal)
article_type: original
author:
- first_name: Simone Anna Elvira
full_name: Rademacher, Simone Anna Elvira
id: 856966FE-A408-11E9-977E-802DE6697425
last_name: Rademacher
orcid: 0000-0001-5059-4466
- first_name: Robert
full_name: Seiringer, Robert
id: 4AFD0470-F248-11E8-B48F-1D18A9856A87
last_name: Seiringer
orcid: 0000-0002-6781-0521
citation:
ama: Rademacher SAE, Seiringer R. Large deviation estimates for weakly interacting
bosons. Journal of Statistical Physics. 2022;188. doi:10.1007/s10955-022-02940-4
apa: Rademacher, S. A. E., & Seiringer, R. (2022). Large deviation estimates
for weakly interacting bosons. Journal of Statistical Physics. Springer
Nature. https://doi.org/10.1007/s10955-022-02940-4
chicago: Rademacher, Simone Anna Elvira, and Robert Seiringer. “Large Deviation
Estimates for Weakly Interacting Bosons.” Journal of Statistical Physics.
Springer Nature, 2022. https://doi.org/10.1007/s10955-022-02940-4.
ieee: S. A. E. Rademacher and R. Seiringer, “Large deviation estimates for weakly
interacting bosons,” Journal of Statistical Physics, vol. 188. Springer
Nature, 2022.
ista: Rademacher SAE, Seiringer R. 2022. Large deviation estimates for weakly interacting
bosons. Journal of Statistical Physics. 188, 9.
mla: Rademacher, Simone Anna Elvira, and Robert Seiringer. “Large Deviation Estimates
for Weakly Interacting Bosons.” Journal of Statistical Physics, vol. 188,
9, Springer Nature, 2022, doi:10.1007/s10955-022-02940-4.
short: S.A.E. Rademacher, R. Seiringer, Journal of Statistical Physics 188 (2022).
date_created: 2022-08-18T07:23:26Z
date_published: 2022-07-01T00:00:00Z
date_updated: 2023-08-03T12:55:58Z
day: '01'
ddc:
- '510'
department:
- _id: RoSe
doi: 10.1007/s10955-022-02940-4
ec_funded: 1
external_id:
isi:
- '000805175000001'
file:
- access_level: open_access
checksum: 44418cb44f07fa21ed3907f85abf7f39
content_type: application/pdf
creator: dernst
date_created: 2022-08-18T08:09:00Z
date_updated: 2022-08-18T08:09:00Z
file_id: '11922'
file_name: 2022_JournalStatisticalPhysics_Rademacher.pdf
file_size: 483481
relation: main_file
success: 1
file_date_updated: 2022-08-18T08:09:00Z
has_accepted_license: '1'
intvolume: ' 188'
isi: 1
keyword:
- Mathematical Physics
- Statistical and Nonlinear Physics
language:
- iso: eng
month: '07'
oa: 1
oa_version: Published Version
project:
- _id: 25C6DC12-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '694227'
name: Analysis of quantum many-body systems
- _id: 260C2330-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '754411'
name: ISTplus - Postdoctoral Fellowships
publication: Journal of Statistical Physics
publication_identifier:
eissn:
- 1572-9613
issn:
- 0022-4715
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
scopus_import: '1'
status: public
title: Large deviation estimates for weakly interacting bosons
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 188
year: '2022'
...
---
_id: '11932'
abstract:
- lang: eng
text: "The ability to form and retrieve memories is central to survival. In mammals,
the hippocampus\r\nis a brain region essential to the acquisition and consolidation
of new memories. It is also\r\ninvolved in keeping track of one’s position in
space and aids navigation. Although this\r\nspace-memory has been a source of
contradiction, evidence supports the view that the role of\r\nthe hippocampus
in navigation is memory, thanks to the formation of cognitive maps. First\r\nintroduced
by Tolman in 1948, cognitive maps are generally used to organize experiences in\r\nmemory;
however, the detailed mechanisms by which these maps are formed and stored are
not\r\nyet agreed upon. Some influential theories describe this process as involving
three fundamental\r\nsteps: initial encoding by the hippocampus, interactions
between the hippocampus and other\r\ncortical areas, and long-term extra-hippocampal
consolidation. In this thesis, I will show how\r\nthe investigation of cognitive
maps of space helped to shed light on each of these three memory\r\nprocesses.\r\nThe
first study included in this thesis deals with the initial encoding of spatial
memories in\r\nthe hippocampus. Much is known about encoding at the level of single
cells, but less about\r\ntheir co-activity or joint contribution to the encoding
of novel spatial information. I will\r\ndescribe the structure of an interaction
network that allows for efficient encoding of noisy\r\nspatial information during
the first exploration of a novel environment.\r\nThe second study describes the
interactions between the hippocampus and the prefrontal\r\ncortex (PFC), two areas
directly and indirectly connected. It is known that the PFC, in concert\r\nwith
the hippocampus, is involved in various processes, including memory storage and
spatial\r\nnavigation. Nonetheless, the detailed mechanisms by which PFC receives
information from the\r\nhippocampus are not clear. I will show how a transient
improvement in theta phase locking of\r\nPFC cells enables interactions of cell
pairs across the two regions.\r\nThe third study describes the learning of behaviorally-relevant
spatial locations in the hippocampus and the medial entorhinal cortex. I will
show how the accumulation of firing around\r\ngoal locations, a correlate of learning,
can shed light on the transition from short- to long-term\r\nspatial memories
and the speed of consolidation in different brain areas.\r\nThe studies included
in this thesis represent the main scientific contributions of my Ph.D. They\r\ninvolve
statistical analyses and models of neural responses of cells in different brain
areas of\r\nrats executing spatial tasks. I will conclude the thesis by discussing
the impact of the findings\r\non principles of memory formation and retention,
including the mechanisms, the speed, and\r\nthe duration of these processes."
acknowledgement: I acknowledge the support from the European Union’s Horizon 2020
research and innovation program under the Marie Skłodowska-Curie Grant Agreement
No. 665385.
alternative_title:
- ISTA Thesis
article_processing_charge: No
author:
- first_name: Michele
full_name: Nardin, Michele
id: 30BD0376-F248-11E8-B48F-1D18A9856A87
last_name: Nardin
orcid: 0000-0001-8849-6570
citation:
ama: Nardin M. On the encoding, transfer, and consolidation of spatial memories.
2022. doi:10.15479/at:ista:11932
apa: Nardin, M. (2022). On the encoding, transfer, and consolidation of spatial
memories. Institute of Science and Technology Austria. https://doi.org/10.15479/at:ista:11932
chicago: Nardin, Michele. “On the Encoding, Transfer, and Consolidation of Spatial
Memories.” Institute of Science and Technology Austria, 2022. https://doi.org/10.15479/at:ista:11932.
ieee: M. Nardin, “On the encoding, transfer, and consolidation of spatial memories,”
Institute of Science and Technology Austria, 2022.
ista: Nardin M. 2022. On the encoding, transfer, and consolidation of spatial memories.
Institute of Science and Technology Austria.
mla: Nardin, Michele. On the Encoding, Transfer, and Consolidation of Spatial
Memories. Institute of Science and Technology Austria, 2022, doi:10.15479/at:ista:11932.
short: M. Nardin, On the Encoding, Transfer, and Consolidation of Spatial Memories,
Institute of Science and Technology Austria, 2022.
date_created: 2022-08-19T08:52:30Z
date_published: 2022-08-19T00:00:00Z
date_updated: 2023-09-05T12:02:14Z
day: '19'
ddc:
- '573'
degree_awarded: PhD
department:
- _id: GradSch
- _id: JoCs
doi: 10.15479/at:ista:11932
ec_funded: 1
file:
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checksum: 2dbb70c74aaa3b64c1f463e943baf09c
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date_created: 2022-08-19T16:31:34Z
date_updated: 2023-06-20T22:30:04Z
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file_size: 13515457
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creator: mnardin
date_created: 2022-08-22T09:43:50Z
date_updated: 2023-06-20T22:30:04Z
embargo: 2023-06-19
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file_name: Michele_Nardin_Phd_Thesis_PDFA.pdf
file_size: 9906458
relation: main_file
file_date_updated: 2023-06-20T22:30:04Z
has_accepted_license: '1'
language:
- iso: eng
month: '08'
oa: 1
oa_version: Published Version
page: '136'
project:
- _id: 2564DBCA-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '665385'
name: International IST Doctoral Program
publication_identifier:
issn:
- 2663-337X
publication_status: published
publisher: Institute of Science and Technology Austria
related_material:
record:
- id: '10077'
relation: part_of_dissertation
status: public
- id: '6194'
relation: part_of_dissertation
status: public
status: public
supervisor:
- first_name: Jozsef L
full_name: Csicsvari, Jozsef L
id: 3FA14672-F248-11E8-B48F-1D18A9856A87
last_name: Csicsvari
orcid: 0000-0002-5193-4036
title: On the encoding, transfer, and consolidation of spatial memories
type: dissertation
user_id: 8b945eb4-e2f2-11eb-945a-df72226e66a9
year: '2022'
...
---
_id: '11937'
abstract:
- lang: eng
text: Most experimentally known high-pressure ice phases have a body-centred cubic
(bcc) oxygen lattice. Our large-scale molecular-dynamics simulations with a machine-learning
potential indicate that, amongst these bcc ice phases, ices VII, VII′ and X are
the same thermodynamic phase under different conditions, whereas superionic ice
VII″ has a first-order phase boundary with ice VII′. Moreover, at about 300 GPa,
the transformation between ice X and the Pbcm phase has a sharp structural change
but no apparent activation barrier, whilst at higher pressures the barrier gradually
increases. Our study thus clarifies the phase behaviour of the high-pressure ices
and reveals peculiar solid–solid transition mechanisms not known in other systems.
acknowledgement: We thank Chris Pickard for providing the initial structures of high-pressure
ice phases and for useful advice. A.R. and B.C. acknowledge resources provided by
the Cambridge Tier-2 system operated by the University of Cambridge Research Computing
Service funded by EPSRC Tier-2 capital grant EP/P020259/1. M.B. was supported by
the European Union within the Marie Skłodowska-Curie actions (xICE grant 894725)
and acknowledges computational resources at North-German Supercomputing Alliance
(HLRN) facilities. S.H. and M.M. acknowledge support from LDRD 19-ERD-031 and computing
support from the Lawrence Livermore National Laboratory (LLNL) Institutional Computing
Grand Challenge programme. F.C. acknowledges support from the US DOE Office of Science,
Office of Fusion Energy Sciences. Lawrence Livermore National Laboratory is operated
by Lawrence Livermore National Security, LLC, for the U.S. Department of Energy,
National Nuclear Security Administration under Contract DE-AC52-07NA27344.
article_number: '4707'
article_processing_charge: No
article_type: original
author:
- first_name: Aleks
full_name: Reinhardt, Aleks
last_name: Reinhardt
- first_name: Mandy
full_name: Bethkenhagen, Mandy
last_name: Bethkenhagen
- first_name: Federica
full_name: Coppari, Federica
last_name: Coppari
- first_name: Marius
full_name: Millot, Marius
last_name: Millot
- first_name: Sebastien
full_name: Hamel, Sebastien
last_name: Hamel
- first_name: Bingqing
full_name: Cheng, Bingqing
id: cbe3cda4-d82c-11eb-8dc7-8ff94289fcc9
last_name: Cheng
orcid: 0000-0002-3584-9632
citation:
ama: Reinhardt A, Bethkenhagen M, Coppari F, Millot M, Hamel S, Cheng B. Thermodynamics
of high-pressure ice phases explored with atomistic simulations. Nature Communications.
2022;13. doi:10.1038/s41467-022-32374-1
apa: Reinhardt, A., Bethkenhagen, M., Coppari, F., Millot, M., Hamel, S., &
Cheng, B. (2022). Thermodynamics of high-pressure ice phases explored with atomistic
simulations. Nature Communications. Springer Nature. https://doi.org/10.1038/s41467-022-32374-1
chicago: Reinhardt, Aleks, Mandy Bethkenhagen, Federica Coppari, Marius Millot,
Sebastien Hamel, and Bingqing Cheng. “Thermodynamics of High-Pressure Ice Phases
Explored with Atomistic Simulations.” Nature Communications. Springer Nature,
2022. https://doi.org/10.1038/s41467-022-32374-1.
ieee: A. Reinhardt, M. Bethkenhagen, F. Coppari, M. Millot, S. Hamel, and B. Cheng,
“Thermodynamics of high-pressure ice phases explored with atomistic simulations,”
Nature Communications, vol. 13. Springer Nature, 2022.
ista: Reinhardt A, Bethkenhagen M, Coppari F, Millot M, Hamel S, Cheng B. 2022.
Thermodynamics of high-pressure ice phases explored with atomistic simulations.
Nature Communications. 13, 4707.
mla: Reinhardt, Aleks, et al. “Thermodynamics of High-Pressure Ice Phases Explored
with Atomistic Simulations.” Nature Communications, vol. 13, 4707, Springer
Nature, 2022, doi:10.1038/s41467-022-32374-1.
short: A. Reinhardt, M. Bethkenhagen, F. Coppari, M. Millot, S. Hamel, B. Cheng,
Nature Communications 13 (2022).
date_created: 2022-08-21T22:01:55Z
date_published: 2022-08-10T00:00:00Z
date_updated: 2023-08-03T13:00:40Z
day: '10'
ddc:
- '540'
department:
- _id: BiCh
doi: 10.1038/s41467-022-32374-1
external_id:
isi:
- '000838655300022'
pmid:
- '35948550'
file:
- access_level: open_access
checksum: 8ff9b689cde59fd3a9959a9f01929dea
content_type: application/pdf
creator: dernst
date_created: 2022-08-22T06:33:02Z
date_updated: 2022-08-22T06:33:02Z
file_id: '11939'
file_name: 2022_NatureCommunications_Reinhardt.pdf
file_size: 1767206
relation: main_file
success: 1
file_date_updated: 2022-08-22T06:33:02Z
has_accepted_license: '1'
intvolume: ' 13'
isi: 1
language:
- iso: eng
month: '08'
oa: 1
oa_version: Published Version
pmid: 1
publication: Nature Communications
publication_identifier:
eissn:
- 2041-1723
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
scopus_import: '1'
status: public
title: Thermodynamics of high-pressure ice phases explored with atomistic simulations
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 13
year: '2022'
...
---
_id: '11938'
abstract:
- lang: eng
text: A matching is compatible to two or more labeled point sets of size n with
labels {1, . . . , n} if its straight-line drawing on each of these point sets
is crossing-free. We study the maximum number of edges in a matching compatible
to two or more labeled point sets in general position in the plane. We show that
for any two labeled sets of n points in convex position there exists a compatible
matching with ⌊√2n + 1 − 1⌋ edges. More generally, for any ℓ labeled point sets
we construct compatible matchings of size Ω(n1/ℓ). As a corresponding upper bound,
we use probabilistic arguments to show that for any ℓ given sets of n points there
exists a labeling of each set such that the largest compatible matching has O(n2/(ℓ+1))
edges. Finally, we show that Θ(log n) copies of any set of n points are necessary
and sufficient for the existence of labelings of these point sets such that any
compatible matching consists only of a single edge.
acknowledgement: 'A.A. funded by the Marie Sklodowska-Curie grant agreement No 754411.
Z.M. partially funded by Wittgenstein Prize, Austrian Science Fund (FWF), grant
no. Z 342-N31. I.P., D.P., and B.V. partially supported by FWF within the collaborative
DACH project Arrangements and Drawings as FWF project I 3340-N35. A.P. supported
by a Schrödinger fellowship of the FWF: J-3847-N35. J.T. partially supported by
ERC Start grant no. (279307: Graph Games), FWF grant no. P23499-N23 and S11407-N23
(RiSE).'
article_processing_charge: No
article_type: original
arxiv: 1
author:
- first_name: Oswin
full_name: Aichholzer, Oswin
last_name: Aichholzer
- first_name: Alan M
full_name: Arroyo Guevara, Alan M
id: 3207FDC6-F248-11E8-B48F-1D18A9856A87
last_name: Arroyo Guevara
orcid: 0000-0003-2401-8670
- first_name: Zuzana
full_name: Masárová, Zuzana
id: 45CFE238-F248-11E8-B48F-1D18A9856A87
last_name: Masárová
orcid: 0000-0002-6660-1322
- first_name: Irene
full_name: Parada, Irene
last_name: Parada
- first_name: Daniel
full_name: Perz, Daniel
last_name: Perz
- first_name: Alexander
full_name: Pilz, Alexander
last_name: Pilz
- first_name: Josef
full_name: Tkadlec, Josef
id: 3F24CCC8-F248-11E8-B48F-1D18A9856A87
last_name: Tkadlec
orcid: 0000-0002-1097-9684
- first_name: Birgit
full_name: Vogtenhuber, Birgit
last_name: Vogtenhuber
citation:
ama: Aichholzer O, Arroyo Guevara AM, Masárová Z, et al. On compatible matchings.
Journal of Graph Algorithms and Applications. 2022;26(2):225-240. doi:10.7155/jgaa.00591
apa: Aichholzer, O., Arroyo Guevara, A. M., Masárová, Z., Parada, I., Perz, D.,
Pilz, A., … Vogtenhuber, B. (2022). On compatible matchings. Journal of Graph
Algorithms and Applications. Brown University. https://doi.org/10.7155/jgaa.00591
chicago: Aichholzer, Oswin, Alan M Arroyo Guevara, Zuzana Masárová, Irene Parada,
Daniel Perz, Alexander Pilz, Josef Tkadlec, and Birgit Vogtenhuber. “On Compatible
Matchings.” Journal of Graph Algorithms and Applications. Brown University,
2022. https://doi.org/10.7155/jgaa.00591.
ieee: O. Aichholzer et al., “On compatible matchings,” Journal of Graph
Algorithms and Applications, vol. 26, no. 2. Brown University, pp. 225–240,
2022.
ista: Aichholzer O, Arroyo Guevara AM, Masárová Z, Parada I, Perz D, Pilz A, Tkadlec
J, Vogtenhuber B. 2022. On compatible matchings. Journal of Graph Algorithms and
Applications. 26(2), 225–240.
mla: Aichholzer, Oswin, et al. “On Compatible Matchings.” Journal of Graph Algorithms
and Applications, vol. 26, no. 2, Brown University, 2022, pp. 225–40, doi:10.7155/jgaa.00591.
short: O. Aichholzer, A.M. Arroyo Guevara, Z. Masárová, I. Parada, D. Perz, A. Pilz,
J. Tkadlec, B. Vogtenhuber, Journal of Graph Algorithms and Applications 26 (2022)
225–240.
date_created: 2022-08-21T22:01:56Z
date_published: 2022-06-01T00:00:00Z
date_updated: 2023-02-23T13:54:21Z
day: '01'
ddc:
- '000'
department:
- _id: UlWa
- _id: HeEd
- _id: KrCh
doi: 10.7155/jgaa.00591
ec_funded: 1
external_id:
arxiv:
- '2101.03928'
file:
- access_level: open_access
checksum: dc6e255e3558faff924fd9e370886c11
content_type: application/pdf
creator: dernst
date_created: 2022-08-22T06:42:42Z
date_updated: 2022-08-22T06:42:42Z
file_id: '11940'
file_name: 2022_JourGraphAlgorithmsApplic_Aichholzer.pdf
file_size: 694538
relation: main_file
success: 1
file_date_updated: 2022-08-22T06:42:42Z
has_accepted_license: '1'
intvolume: ' 26'
issue: '2'
language:
- iso: eng
month: '06'
oa: 1
oa_version: Published Version
page: 225-240
project:
- _id: 260C2330-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '754411'
name: ISTplus - Postdoctoral Fellowships
- _id: 268116B8-B435-11E9-9278-68D0E5697425
call_identifier: FWF
grant_number: Z00342
name: The Wittgenstein Prize
- _id: 2581B60A-B435-11E9-9278-68D0E5697425
call_identifier: FP7
grant_number: '279307'
name: 'Quantitative Graph Games: Theory and Applications'
- _id: 2584A770-B435-11E9-9278-68D0E5697425
call_identifier: FWF
grant_number: P 23499-N23
name: Modern Graph Algorithmic Techniques in Formal Verification
- _id: 25863FF4-B435-11E9-9278-68D0E5697425
call_identifier: FWF
grant_number: S11407
name: Game Theory
publication: Journal of Graph Algorithms and Applications
publication_identifier:
issn:
- 1526-1719
publication_status: published
publisher: Brown University
quality_controlled: '1'
related_material:
record:
- id: '9296'
relation: earlier_version
status: public
scopus_import: '1'
status: public
title: On compatible matchings
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 26
year: '2022'
...
---
_id: '11943'
abstract:
- lang: eng
text: Complex wiring between neurons underlies the information-processing network
enabling all brain functions, including cognition and memory. For understanding
how the network is structured, processes information, and changes over time, comprehensive
visualization of the architecture of living brain tissue with its cellular and
molecular components would open up major opportunities. However, electron microscopy
(EM) provides nanometre-scale resolution required for full in-silico
reconstruction1–5, yet is limited to fixed specimens and
static representations. Light microscopy allows live observation, with super-resolution
approaches6–12 facilitating nanoscale visualization, but
comprehensive 3D-reconstruction of living brain tissue has been hindered by tissue
photo-burden, photobleaching, insufficient 3D-resolution, and inadequate signal-to-noise
ratio (SNR). Here we demonstrate saturated reconstruction of living brain tissue.
We developed an integrated imaging and analysis technology, adapting stimulated
emission depletion (STED) microscopy6,13 in extracellularly
labelled tissue14 for high SNR and near-isotropic resolution.
Centrally, a two-stage deep-learning approach leveraged previously obtained information
on sample structure to drastically reduce photo-burden and enable automated volumetric
reconstruction down to single synapse level. Live reconstruction provides unbiased
analysis of tissue architecture across time in relation to functional activity
and targeted activation, and contextual understanding of molecular labelling.
This adoptable technology will facilitate novel insights into the dynamic functional
architecture of living brain tissue.
article_processing_charge: No
author:
- first_name: Philipp
full_name: Velicky, Philipp
id: 39BDC62C-F248-11E8-B48F-1D18A9856A87
last_name: Velicky
orcid: 0000-0002-2340-7431
- first_name: Eder
full_name: Miguel Villalba, Eder
id: 3FB91342-F248-11E8-B48F-1D18A9856A87
last_name: Miguel Villalba
orcid: 0000-0001-5665-0430
- first_name: Julia M
full_name: Michalska, Julia M
id: 443DB6DE-F248-11E8-B48F-1D18A9856A87
last_name: Michalska
orcid: 0000-0003-3862-1235
- first_name: Donglai
full_name: Wei, Donglai
last_name: Wei
- first_name: Zudi
full_name: Lin, Zudi
last_name: Lin
- first_name: Jake
full_name: Watson, Jake
id: 63836096-4690-11EA-BD4E-32803DDC885E
last_name: Watson
orcid: 0000-0002-8698-3823
- first_name: Jakob
full_name: Troidl, Jakob
last_name: Troidl
- first_name: Johanna
full_name: Beyer, Johanna
last_name: Beyer
- first_name: Yoav
full_name: Ben Simon, Yoav
id: 43DF3136-F248-11E8-B48F-1D18A9856A87
last_name: Ben Simon
- first_name: Christoph M
full_name: Sommer, Christoph M
id: 4DF26D8C-F248-11E8-B48F-1D18A9856A87
last_name: Sommer
orcid: 0000-0003-1216-9105
- first_name: Wiebke
full_name: Jahr, Wiebke
id: 425C1CE8-F248-11E8-B48F-1D18A9856A87
last_name: Jahr
- first_name: Alban
full_name: Cenameri, Alban
id: 9ac8f577-2357-11eb-997a-e566c5550886
last_name: Cenameri
- first_name: Johannes
full_name: Broichhagen, Johannes
last_name: Broichhagen
- first_name: Seth G. N.
full_name: Grant, Seth G. N.
last_name: Grant
- first_name: Peter M
full_name: Jonas, Peter M
id: 353C1B58-F248-11E8-B48F-1D18A9856A87
last_name: Jonas
orcid: 0000-0001-5001-4804
- first_name: Gaia
full_name: Novarino, Gaia
id: 3E57A680-F248-11E8-B48F-1D18A9856A87
last_name: Novarino
orcid: 0000-0002-7673-7178
- first_name: Hanspeter
full_name: Pfister, Hanspeter
last_name: Pfister
- first_name: Bernd
full_name: Bickel, Bernd
id: 49876194-F248-11E8-B48F-1D18A9856A87
last_name: Bickel
orcid: 0000-0001-6511-9385
- first_name: Johann G
full_name: Danzl, Johann G
id: 42EFD3B6-F248-11E8-B48F-1D18A9856A87
last_name: Danzl
orcid: 0000-0001-8559-3973
citation:
ama: Velicky P, Miguel Villalba E, Michalska JM, et al. Saturated reconstruction
of living brain tissue. bioRxiv. doi:10.1101/2022.03.16.484431
apa: Velicky, P., Miguel Villalba, E., Michalska, J. M., Wei, D., Lin, Z., Watson,
J., … Danzl, J. G. (n.d.). Saturated reconstruction of living brain tissue. bioRxiv.
Cold Spring Harbor Laboratory. https://doi.org/10.1101/2022.03.16.484431
chicago: Velicky, Philipp, Eder Miguel Villalba, Julia M Michalska, Donglai Wei,
Zudi Lin, Jake Watson, Jakob Troidl, et al. “Saturated Reconstruction of Living
Brain Tissue.” BioRxiv. Cold Spring Harbor Laboratory, n.d. https://doi.org/10.1101/2022.03.16.484431.
ieee: P. Velicky et al., “Saturated reconstruction of living brain tissue,”
bioRxiv. Cold Spring Harbor Laboratory.
ista: Velicky P, Miguel Villalba E, Michalska JM, Wei D, Lin Z, Watson J, Troidl
J, Beyer J, Ben Simon Y, Sommer CM, Jahr W, Cenameri A, Broichhagen J, Grant SGN,
Jonas PM, Novarino G, Pfister H, Bickel B, Danzl JG. Saturated reconstruction
of living brain tissue. bioRxiv, 10.1101/2022.03.16.484431.
mla: Velicky, Philipp, et al. “Saturated Reconstruction of Living Brain Tissue.”
BioRxiv, Cold Spring Harbor Laboratory, doi:10.1101/2022.03.16.484431.
short: P. Velicky, E. Miguel Villalba, J.M. Michalska, D. Wei, Z. Lin, J. Watson,
J. Troidl, J. Beyer, Y. Ben Simon, C.M. Sommer, W. Jahr, A. Cenameri, J. Broichhagen,
S.G.N. Grant, P.M. Jonas, G. Novarino, H. Pfister, B. Bickel, J.G. Danzl, BioRxiv
(n.d.).
date_created: 2022-08-23T11:07:59Z
date_published: 2022-05-09T00:00:00Z
date_updated: 2024-03-25T23:30:11Z
day: '09'
department:
- _id: PeJo
- _id: GaNo
- _id: BeBi
- _id: JoDa
doi: 10.1101/2022.03.16.484431
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://doi.org/10.1101/2022.03.16.484431
month: '05'
oa: 1
oa_version: Preprint
publication: bioRxiv
publication_status: submitted
publisher: Cold Spring Harbor Laboratory
related_material:
record:
- id: '12470'
relation: dissertation_contains
status: public
status: public
title: Saturated reconstruction of living brain tissue
type: preprint
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '2022'
...
---
_id: '11945'
abstract:
- lang: eng
text: "G protein-coupled receptors (GPCRs) respond to specific ligands and regulate
multiple processes ranging from cell growth and immune responses to neuronal signal
transmission. However, ligands for many GPCRs remain unknown, suffer from off-target
effects or have poor bioavailability. Additional challenges exist to dissect cell-type
specific responses when the same GPCR is expressed on several cell types within
the body. Here, we overcome these limitations by engineering DREADD-based GPCR
chimeras that selectively bind their agonist clozapine-N-oxide (CNO) and mimic
a GPCR-of-interest in a desired cell type.\r\nWe validated our approach with β2-adrenergic
receptor (β2AR/ADRB2) and show that our chimeric DREADD-β2AR triggers comparable
responses on second messenger and kinase activity, post-translational modifications,
and protein-protein interactions. Since β2AR is also enriched in microglia, which
can drive inflammation in the central nervous system, we expressed chimeric DREADD-β2AR
in primary microglia and successfully recapitulate β2AR-mediated filopodia formation
through CNO stimulation. To dissect the role of selected GPCRs during microglial
inflammation, we additionally generated DREADD-based chimeras for microglia-enriched
GPR65 and GPR109A/HCAR2. In a microglia cell line, DREADD-β2AR and DREADD-GPR65
both modulated the inflammatory response with a similar profile as endogenously
expressed β2AR, while DREADD-GPR109A showed no impact.\r\nOur DREADD-based approach
provides the means to obtain mechanistic and functional insights into GPCR signaling
on a cell-type specific level."
acknowledged_ssus:
- _id: Bio
- _id: PreCl
- _id: LifeSc
alternative_title:
- ISTA Thesis
article_processing_charge: No
author:
- first_name: Rouven
full_name: Schulz, Rouven
id: 4C5E7B96-F248-11E8-B48F-1D18A9856A87
last_name: Schulz
orcid: 0000-0001-5297-733X
citation:
ama: Schulz R. Chimeric G protein-coupled receptors mimic distinct signaling pathways
and modulate microglia function. 2022. doi:10.15479/at:ista:11945
apa: Schulz, R. (2022). Chimeric G protein-coupled receptors mimic distinct signaling
pathways and modulate microglia function. Institute of Science and Technology
Austria. https://doi.org/10.15479/at:ista:11945
chicago: Schulz, Rouven. “Chimeric G Protein-Coupled Receptors Mimic Distinct Signaling
Pathways and Modulate Microglia Function.” Institute of Science and Technology
Austria, 2022. https://doi.org/10.15479/at:ista:11945.
ieee: R. Schulz, “Chimeric G protein-coupled receptors mimic distinct signaling
pathways and modulate microglia function,” Institute of Science and Technology
Austria, 2022.
ista: Schulz R. 2022. Chimeric G protein-coupled receptors mimic distinct signaling
pathways and modulate microglia function. Institute of Science and Technology
Austria.
mla: Schulz, Rouven. Chimeric G Protein-Coupled Receptors Mimic Distinct Signaling
Pathways and Modulate Microglia Function. Institute of Science and Technology
Austria, 2022, doi:10.15479/at:ista:11945.
short: R. Schulz, Chimeric G Protein-Coupled Receptors Mimic Distinct Signaling
Pathways and Modulate Microglia Function, Institute of Science and Technology
Austria, 2022.
date_created: 2022-08-23T11:33:11Z
date_published: 2022-08-23T00:00:00Z
date_updated: 2023-08-03T13:02:26Z
day: '23'
ddc:
- '570'
degree_awarded: PhD
department:
- _id: GradSch
- _id: SaSi
doi: 10.15479/at:ista:11945
file:
- access_level: open_access
checksum: 61b1b666a210ff7cdd0e95ea75207a13
content_type: application/pdf
creator: rschulz
date_created: 2022-08-25T08:59:57Z
date_updated: 2022-08-25T08:59:57Z
file_id: '11970'
file_name: Thesis_Rouven_Schulz_2022_final.pdf
file_size: 28079331
relation: main_file
success: 1
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checksum: 2b8f95ea1c134dbdb927b41b1dbeeeb5
content_type: application/vnd.openxmlformats-officedocument.wordprocessingml.document
creator: rschulz
date_created: 2022-08-25T09:00:11Z
date_updated: 2022-08-25T09:33:31Z
file_id: '11971'
file_name: Thesis_Rouven_Schulz_2022_final.docx
file_size: 27226963
relation: source_file
file_date_updated: 2022-08-25T09:33:31Z
has_accepted_license: '1'
language:
- iso: eng
month: '08'
oa: 1
oa_version: Published Version
page: '133'
project:
- _id: 267F75D8-B435-11E9-9278-68D0E5697425
name: Modulating microglia through G protein-coupled receptor (GPCR) signaling
publication_identifier:
issn:
- 2663-337X
publication_status: published
publisher: Institute of Science and Technology Austria
related_material:
record:
- id: '11995'
relation: dissertation_contains
status: public
status: public
supervisor:
- first_name: Sandra
full_name: Siegert, Sandra
id: 36ACD32E-F248-11E8-B48F-1D18A9856A87
last_name: Siegert
orcid: 0000-0001-8635-0877
title: Chimeric G protein-coupled receptors mimic distinct signaling pathways and
modulate microglia function
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: dissertation
user_id: 8b945eb4-e2f2-11eb-945a-df72226e66a9
year: '2022'
...
---
_id: '11950'
abstract:
- lang: eng
text: Mapping the complex and dense arrangement of cells and their connectivity
in brain tissue demands nanoscale spatial resolution imaging. Super-resolution
optical microscopy excels at visualizing specific molecules and individual cells
but fails to provide tissue context. Here we developed Comprehensive Analysis
of Tissues across Scales (CATS), a technology to densely map brain tissue architecture
from millimeter regional to nanoscopic synaptic scales in diverse chemically fixed
brain preparations, including rodent and human. CATS leverages fixation-compatible
extracellular labeling and advanced optical readout, in particular stimulated-emission
depletion and expansion microscopy, to comprehensively delineate cellular structures.
It enables 3D-reconstructing single synapses and mapping synaptic connectivity
by identification and tailored analysis of putative synaptic cleft regions. Applying
CATS to the hippocampal mossy fiber circuitry, we demonstrate its power to reveal
the system’s molecularly informed ultrastructure across spatial scales and assess
local connectivity by reconstructing and quantifying the synaptic input and output
structure of identified neurons.
article_processing_charge: No
author:
- first_name: Julia M
full_name: Michalska, Julia M
id: 443DB6DE-F248-11E8-B48F-1D18A9856A87
last_name: Michalska
orcid: 0000-0003-3862-1235
- first_name: Julia
full_name: Lyudchik, Julia
id: 46E28B80-F248-11E8-B48F-1D18A9856A87
last_name: Lyudchik
- first_name: Philipp
full_name: Velicky, Philipp
id: 39BDC62C-F248-11E8-B48F-1D18A9856A87
last_name: Velicky
orcid: 0000-0002-2340-7431
- first_name: Hana
full_name: Korinkova, Hana
id: ee3cb6ca-ec98-11ea-ae11-ff703e2254ed
last_name: Korinkova
- first_name: Jake
full_name: Watson, Jake
id: 63836096-4690-11EA-BD4E-32803DDC885E
last_name: Watson
orcid: 0000-0002-8698-3823
- first_name: Alban
full_name: Cenameri, Alban
id: 9ac8f577-2357-11eb-997a-e566c5550886
last_name: Cenameri
- first_name: Christoph M
full_name: Sommer, Christoph M
id: 4DF26D8C-F248-11E8-B48F-1D18A9856A87
last_name: Sommer
orcid: 0000-0003-1216-9105
- first_name: Alessandro
full_name: Venturino, Alessandro
id: 41CB84B2-F248-11E8-B48F-1D18A9856A87
last_name: Venturino
orcid: 0000-0003-2356-9403
- first_name: Karl
full_name: Roessler, Karl
last_name: Roessler
- first_name: Thomas
full_name: Czech, Thomas
last_name: Czech
- first_name: Sandra
full_name: Siegert, Sandra
id: 36ACD32E-F248-11E8-B48F-1D18A9856A87
last_name: Siegert
orcid: 0000-0001-8635-0877
- first_name: Gaia
full_name: Novarino, Gaia
id: 3E57A680-F248-11E8-B48F-1D18A9856A87
last_name: Novarino
orcid: 0000-0002-7673-7178
- first_name: Peter M
full_name: Jonas, Peter M
id: 353C1B58-F248-11E8-B48F-1D18A9856A87
last_name: Jonas
orcid: 0000-0001-5001-4804
- first_name: Johann G
full_name: Danzl, Johann G
id: 42EFD3B6-F248-11E8-B48F-1D18A9856A87
last_name: Danzl
orcid: 0000-0001-8559-3973
citation:
ama: Michalska JM, Lyudchik J, Velicky P, et al. Uncovering brain tissue architecture
across scales with super-resolution light microscopy. bioRxiv. doi:10.1101/2022.08.17.504272
apa: Michalska, J. M., Lyudchik, J., Velicky, P., Korinkova, H., Watson, J., Cenameri,
A., … Danzl, J. G. (n.d.). Uncovering brain tissue architecture across scales
with super-resolution light microscopy. bioRxiv. Cold Spring Harbor Laboratory.
https://doi.org/10.1101/2022.08.17.504272
chicago: Michalska, Julia M, Julia Lyudchik, Philipp Velicky, Hana Korinkova, Jake
Watson, Alban Cenameri, Christoph M Sommer, et al. “Uncovering Brain Tissue Architecture
across Scales with Super-Resolution Light Microscopy.” BioRxiv. Cold Spring
Harbor Laboratory, n.d. https://doi.org/10.1101/2022.08.17.504272.
ieee: J. M. Michalska et al., “Uncovering brain tissue architecture across
scales with super-resolution light microscopy,” bioRxiv. Cold Spring Harbor
Laboratory.
ista: Michalska JM, Lyudchik J, Velicky P, Korinkova H, Watson J, Cenameri A, Sommer
CM, Venturino A, Roessler K, Czech T, Siegert S, Novarino G, Jonas PM, Danzl JG.
Uncovering brain tissue architecture across scales with super-resolution light
microscopy. bioRxiv, 10.1101/2022.08.17.504272.
mla: Michalska, Julia M., et al. “Uncovering Brain Tissue Architecture across Scales
with Super-Resolution Light Microscopy.” BioRxiv, Cold Spring Harbor Laboratory,
doi:10.1101/2022.08.17.504272.
short: J.M. Michalska, J. Lyudchik, P. Velicky, H. Korinkova, J. Watson, A. Cenameri,
C.M. Sommer, A. Venturino, K. Roessler, T. Czech, S. Siegert, G. Novarino, P.M.
Jonas, J.G. Danzl, BioRxiv (n.d.).
date_created: 2022-08-24T08:24:52Z
date_published: 2022-08-18T00:00:00Z
date_updated: 2024-03-25T23:30:11Z
day: '18'
department:
- _id: SaSi
- _id: GaNo
- _id: PeJo
- _id: JoDa
doi: 10.1101/2022.08.17.504272
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://doi.org/10.1101/2022.08.17.504272
month: '08'
oa: 1
oa_version: Preprint
publication: bioRxiv
publication_status: submitted
publisher: Cold Spring Harbor Laboratory
related_material:
record:
- id: '12470'
relation: dissertation_contains
status: public
status: public
title: Uncovering brain tissue architecture across scales with super-resolution light
microscopy
type: preprint
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '2022'
...