---
_id: '11451'
abstract:
- lang: eng
  text: The precursor conversion chemistry and surface chemistry of Cu3N and Cu3PdN
    nanocrystals are unknown or contested. Here, we first obtain phase-pure, colloidally
    stable nanocubes. Second, we elucidate the pathway by which copper(II) nitrate
    and oleylamine form Cu3N. We find that oleylamine is both a reductant and a nitrogen
    source. Oleylamine is oxidized by nitrate to a primary aldimine, which reacts
    further with excess oleylamine to a secondary aldimine, eliminating ammonia. Ammonia
    reacts with CuI to form Cu3N. Third, we investigated the surface chemistry and
    find a mixed ligand shell of aliphatic amines and carboxylates (formed in situ).
    While the carboxylates appear tightly bound, the amines are easily desorbed from
    the surface. Finally, we show that doping with palladium decreases the band gap
    and the material becomes semi-metallic. These results bring insight into the chemistry
    of metal nitrides and might help the development of other metal nitride nanocrystals.
acknowledgement: 'J.D.R. and M.P. acknowledge the SNF Eccellenza funding scheme (project
  number: 194172). We acknowledge DESY (Hamburg, Germany), a member of the Helmholtz
  Association HGF, for the provision of experimental facilities. Parts of this research
  were carried out at beamline P21.1, PETRA III. We thank Dr. Soham Banerjee for acquiring
  the PDF data and helpful advice. A.R. acknowledges the support from the Analytical
  Chemistry Trust Fund for her CAMS-UK Fellowship. C.K. acknowledges the support from
  the Department of Chemistry, UCL. The authors acknowledge Dr Stephan Lany from NREL
  for providing the Cu3N DFT calculations. The authors thank Prof. Raymond Schaak
  and Dr. Robert William Lord for helpful advice and suggestions regarding the purification
  procedure. Open access funding provided by Universitat Basel.'
article_number: e202207013
article_processing_charge: No
article_type: original
author:
- first_name: Mahsa
  full_name: Parvizian, Mahsa
  last_name: Parvizian
- first_name: Alejandra
  full_name: Duràn Balsa, Alejandra
  last_name: Duràn Balsa
- first_name: Rohan
  full_name: Pokratath, Rohan
  last_name: Pokratath
- first_name: Curran
  full_name: Kalha, Curran
  last_name: Kalha
- first_name: Seungho
  full_name: Lee, Seungho
  id: BB243B88-D767-11E9-B658-BC13E6697425
  last_name: Lee
  orcid: 0000-0002-6962-8598
- first_name: Dietger
  full_name: Van Den Eynden, Dietger
  last_name: Van Den Eynden
- first_name: Maria
  full_name: Ibáñez, Maria
  id: 43C61214-F248-11E8-B48F-1D18A9856A87
  last_name: Ibáñez
  orcid: 0000-0001-5013-2843
- first_name: Anna
  full_name: Regoutz, Anna
  last_name: Regoutz
- first_name: Jonathan
  full_name: De Roo, Jonathan
  last_name: De Roo
citation:
  ama: Parvizian M, Duràn Balsa A, Pokratath R, et al. The chemistry of Cu₃N and Cu₃PdN
    nanocrystals. <i>Angewandte Chemie - International Edition</i>. 2022;61(31). doi:<a
    href="https://doi.org/10.1002/anie.202207013">10.1002/anie.202207013</a>
  apa: Parvizian, M., Duràn Balsa, A., Pokratath, R., Kalha, C., Lee, S., Van Den
    Eynden, D., … De Roo, J. (2022). The chemistry of Cu₃N and Cu₃PdN nanocrystals.
    <i>Angewandte Chemie - International Edition</i>. Wiley. <a href="https://doi.org/10.1002/anie.202207013">https://doi.org/10.1002/anie.202207013</a>
  chicago: Parvizian, Mahsa, Alejandra Duràn Balsa, Rohan Pokratath, Curran Kalha,
    Seungho Lee, Dietger Van Den Eynden, Maria Ibáñez, Anna Regoutz, and Jonathan
    De Roo. “The Chemistry of Cu₃N and Cu₃PdN Nanocrystals.” <i>Angewandte Chemie
    - International Edition</i>. Wiley, 2022. <a href="https://doi.org/10.1002/anie.202207013">https://doi.org/10.1002/anie.202207013</a>.
  ieee: M. Parvizian <i>et al.</i>, “The chemistry of Cu₃N and Cu₃PdN nanocrystals,”
    <i>Angewandte Chemie - International Edition</i>, vol. 61, no. 31. Wiley, 2022.
  ista: Parvizian M, Duràn Balsa A, Pokratath R, Kalha C, Lee S, Van Den Eynden D,
    Ibáñez M, Regoutz A, De Roo J. 2022. The chemistry of Cu₃N and Cu₃PdN nanocrystals.
    Angewandte Chemie - International Edition. 61(31), e202207013.
  mla: Parvizian, Mahsa, et al. “The Chemistry of Cu₃N and Cu₃PdN Nanocrystals.” <i>Angewandte
    Chemie - International Edition</i>, vol. 61, no. 31, e202207013, Wiley, 2022,
    doi:<a href="https://doi.org/10.1002/anie.202207013">10.1002/anie.202207013</a>.
  short: M. Parvizian, A. Duràn Balsa, R. Pokratath, C. Kalha, S. Lee, D. Van Den
    Eynden, M. Ibáñez, A. Regoutz, J. De Roo, Angewandte Chemie - International Edition
    61 (2022).
date_created: 2022-06-19T22:01:58Z
date_published: 2022-08-01T00:00:00Z
date_updated: 2023-08-03T07:19:12Z
day: '01'
ddc:
- '540'
department:
- _id: MaIb
doi: 10.1002/anie.202207013
external_id:
  isi:
  - '000811084000001'
  pmid:
  - '35612297'
file:
- access_level: open_access
  checksum: 2a3ee0bb59e044b808ebe85cd94ac899
  content_type: application/pdf
  creator: dernst
  date_created: 2022-07-29T09:29:20Z
  date_updated: 2022-07-29T09:29:20Z
  file_id: '11696'
  file_name: 2022_AngewandteChemieInternat_Parvizian.pdf
  file_size: 1303202
  relation: main_file
  success: 1
file_date_updated: 2022-07-29T09:29:20Z
has_accepted_license: '1'
intvolume: '        61'
isi: 1
issue: '31'
language:
- iso: eng
month: '08'
oa: 1
oa_version: Published Version
pmid: 1
publication: Angewandte Chemie - International Edition
publication_identifier:
  eissn:
  - 1521-3773
  issn:
  - 1433-7851
publication_status: published
publisher: Wiley
quality_controlled: '1'
related_material:
  record:
  - id: '11695'
    relation: research_data
    status: public
scopus_import: '1'
status: public
title: The chemistry of Cu₃N and Cu₃PdN nanocrystals
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 61
year: '2022'
...
---
_id: '11456'
abstract:
- lang: eng
  text: The proteomes of specialized structures, and the interactomes of proteins
    of interest, provide entry points to elucidate the functions of molecular machines.
    Here, we review a proximity-labeling strategy that uses the improved E. coli biotin
    ligase TurboID to characterize C. elegans protein complexes. Although the focus
    is on C. elegans neurons, the method is applicable regardless of cell type. We
    describe detailed extraction procedures that solubilize the bulk of C. elegans
    proteins and highlight the importance of tagging endogenous genes, to ensure physiological
    expression levels. We review issues associated with non-specific background noise
    and the importance of appropriate controls. As proof of principle, we review our
    analysis of the interactome of a presynaptic active zone protein, ELKS-1. Our
    aim is to provide a detailed protocol for TurboID-based proximity labeling in
    C. elegans and to highlight its potential and its limitations to characterize
    protein complexes and subcellular compartments in this animal.
acknowledgement: We thank de Bono lab members for the helpful comments on the manuscript.
  The biotin-auxotrophic E. coli strain MG1655bioB:kan was a generous gift from J.
  Cronan (University of Illinois) and was kindly sent to us by Jessica Feldman and
  Ariana Sanchez (Stanford University). dg398 pEntryslot2_mNeongreen::3XFLAG::stop
  and dg397 pEntryslot3_mNeongreen::3XFLAG::stop::unc-54 3’UTR entry vector were kindly
  sent by Dr. Dominique Glauser (University of Fribourg). This work was supported
  by an Advanced ERC Grant (269058 ACMO) and a Wellcome Investigator Award (209504/Z/17/Z)
  to MdB and an ISTplus Fellowship to MA (Marie Sklodowska-Curie agreement No 754411).
alternative_title:
- Neuromethods
article_processing_charge: No
author:
- first_name: Murat
  full_name: Artan, Murat
  id: C407B586-6052-11E9-B3AE-7006E6697425
  last_name: Artan
- first_name: Mario
  full_name: de Bono, Mario
  id: 4E3FF80E-F248-11E8-B48F-1D18A9856A87
  last_name: de Bono
  orcid: 0000-0001-8347-0443
citation:
  ama: 'Artan M, de Bono M. Proteomic Analysis of C. Elegans Neurons Using TurboID-Based
    Proximity Labeling. In: Yamamoto D, ed. <i>Behavioral Neurogenetics</i>. Vol 181.
    NM. New York: Springer Nature; 2022:277-294. doi:<a href="https://doi.org/10.1007/978-1-0716-2321-3_15">10.1007/978-1-0716-2321-3_15</a>'
  apa: 'Artan, M., &#38; de Bono, M. (2022). Proteomic Analysis of C. Elegans Neurons
    Using TurboID-Based Proximity Labeling. In D. Yamamoto (Ed.), <i>Behavioral Neurogenetics</i>
    (Vol. 181, pp. 277–294). New York: Springer Nature. <a href="https://doi.org/10.1007/978-1-0716-2321-3_15">https://doi.org/10.1007/978-1-0716-2321-3_15</a>'
  chicago: 'Artan, Murat, and Mario de Bono. “Proteomic Analysis of C. Elegans Neurons
    Using TurboID-Based Proximity Labeling.” In <i>Behavioral Neurogenetics</i>, edited
    by Daisuke Yamamoto, 181:277–94. NM. New York: Springer Nature, 2022. <a href="https://doi.org/10.1007/978-1-0716-2321-3_15">https://doi.org/10.1007/978-1-0716-2321-3_15</a>.'
  ieee: 'M. Artan and M. de Bono, “Proteomic Analysis of C. Elegans Neurons Using
    TurboID-Based Proximity Labeling,” in <i>Behavioral Neurogenetics</i>, vol. 181,
    D. Yamamoto, Ed. New York: Springer Nature, 2022, pp. 277–294.'
  ista: 'Artan M, de Bono M. 2022.Proteomic Analysis of C. Elegans Neurons Using TurboID-Based
    Proximity Labeling. In: Behavioral Neurogenetics. Neuromethods, vol. 181, 277–294.'
  mla: Artan, Murat, and Mario de Bono. “Proteomic Analysis of C. Elegans Neurons
    Using TurboID-Based Proximity Labeling.” <i>Behavioral Neurogenetics</i>, edited
    by Daisuke Yamamoto, vol. 181, Springer Nature, 2022, pp. 277–94, doi:<a href="https://doi.org/10.1007/978-1-0716-2321-3_15">10.1007/978-1-0716-2321-3_15</a>.
  short: M. Artan, M. de Bono, in:, D. Yamamoto (Ed.), Behavioral Neurogenetics, Springer
    Nature, New York, 2022, pp. 277–294.
date_created: 2022-06-20T08:10:34Z
date_published: 2022-06-04T00:00:00Z
date_updated: 2023-02-21T09:51:55Z
day: '04'
department:
- _id: MaDe
doi: 10.1007/978-1-0716-2321-3_15
ec_funded: 1
editor:
- first_name: Daisuke
  full_name: Yamamoto, Daisuke
  last_name: Yamamoto
intvolume: '       181'
language:
- iso: eng
month: '06'
oa_version: None
page: 277-294
place: New York
project:
- _id: 23870BE8-32DE-11EA-91FC-C7463DDC885E
  grant_number: 209504/A/17/Z
  name: Molecular mechanisms of neural circuit function
- _id: 260C2330-B435-11E9-9278-68D0E5697425
  call_identifier: H2020
  grant_number: '754411'
  name: ISTplus - Postdoctoral Fellowships
publication: Behavioral Neurogenetics
publication_identifier:
  eisbn:
  - '9781071623213'
  eissn:
  - 1940-6045
  isbn:
  - '9781071623206'
  issn:
  - 0893-2336
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
scopus_import: '1'
series_title: NM
status: public
title: Proteomic Analysis of C. Elegans Neurons Using TurboID-Based Proximity Labeling
type: book_chapter
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 181
year: '2022'
...
---
_id: '11459'
abstract:
- lang: eng
  text: 'We present a novel approach to differential cost analysis that, given a program
    revision, attempts to statically bound the difference in resource usage, or cost,
    between the two program versions. Differential cost analysis is particularly interesting
    because of the many compelling applications for it, such as detecting resource-use
    regressions at code-review time or proving the absence of certain side-channel
    vulnerabilities. One prior approach to differential cost analysis is to apply
    relational reasoning that conceptually constructs a product program on which one
    can over-approximate the difference in costs between the two program versions.
    However, a significant challenge in any relational approach is effectively aligning
    the program versions to get precise results. In this paper, our key insight is
    that we can avoid the need for and the limitations of program alignment if, instead,
    we bound the difference of two cost-bound summaries rather than directly bounding
    the concrete cost difference. In particular, our method computes a threshold value
    for the maximal difference in cost between two program versions simultaneously
    using two kinds of cost-bound summaries---a potential function that evaluates
    to an upper bound for the cost incurred in the first program and an anti-potential
    function that evaluates to a lower bound for the cost incurred in the second.
    Our method has a number of desirable properties: it can be fully automated, it
    allows optimizing the threshold value on relative cost, it is suitable for programs
    that are not syntactically similar, and it supports non-determinism. We have evaluated
    an implementation of our approach on a number of program pairs collected from
    the literature, and we find that our method computes tight threshold values on
    relative cost in most examples.'
acknowledgement: "We thank Shaun Willows, Thomas Lugnet, and the Living Room Application
  Vending team for suggesting threshold\r\nbounds as a developer-friendly way to interact
  with a differential cost analyzer, and we thank Jim Christy, Daniel\r\nSchoepe,
  and the Prime Video Automated Reasoning team for their support and helpful suggestions
  throughout the\r\nproject. We also thank Michael Emmi for feedback on an earlier
  version of this paper. And finally, we thank the anonymous reviewers for their useful
  feedback and Aws Albarghouthi for shepherding the final version of the paper. Ðorđe
  Žikelić was also partially supported by ERC CoG 863818 (FoRM-SMArt)."
article_processing_charge: No
arxiv: 1
author:
- first_name: Dorde
  full_name: Zikelic, Dorde
  id: 294AA7A6-F248-11E8-B48F-1D18A9856A87
  last_name: Zikelic
  orcid: 0000-0002-4681-1699
- first_name: Bor-Yuh Evan
  full_name: Chang, Bor-Yuh Evan
  last_name: Chang
- first_name: Pauline
  full_name: Bolignano, Pauline
  last_name: Bolignano
- first_name: Franco
  full_name: Raimondi, Franco
  last_name: Raimondi
citation:
  ama: 'Zikelic D, Chang B-YE, Bolignano P, Raimondi F. Differential cost analysis
    with simultaneous potentials and anti-potentials. In: <i>Proceedings of the 43rd
    ACM SIGPLAN International Conference on Programming Language Design and Implementation</i>.
    Association for Computing Machinery; 2022:442-457. doi:<a href="https://doi.org/10.1145/3519939.3523435">10.1145/3519939.3523435</a>'
  apa: 'Zikelic, D., Chang, B.-Y. E., Bolignano, P., &#38; Raimondi, F. (2022). Differential
    cost analysis with simultaneous potentials and anti-potentials. In <i>Proceedings
    of the 43rd ACM SIGPLAN International Conference on Programming Language Design
    and Implementation</i> (pp. 442–457). San Diego, CA, United States: Association
    for Computing Machinery. <a href="https://doi.org/10.1145/3519939.3523435">https://doi.org/10.1145/3519939.3523435</a>'
  chicago: Zikelic, Dorde, Bor-Yuh Evan Chang, Pauline Bolignano, and Franco Raimondi.
    “Differential Cost Analysis with Simultaneous Potentials and Anti-Potentials.”
    In <i>Proceedings of the 43rd ACM SIGPLAN International Conference on Programming
    Language Design and Implementation</i>, 442–57. Association for Computing Machinery,
    2022. <a href="https://doi.org/10.1145/3519939.3523435">https://doi.org/10.1145/3519939.3523435</a>.
  ieee: D. Zikelic, B.-Y. E. Chang, P. Bolignano, and F. Raimondi, “Differential cost
    analysis with simultaneous potentials and anti-potentials,” in <i>Proceedings
    of the 43rd ACM SIGPLAN International Conference on Programming Language Design
    and Implementation</i>, San Diego, CA, United States, 2022, pp. 442–457.
  ista: 'Zikelic D, Chang B-YE, Bolignano P, Raimondi F. 2022. Differential cost analysis
    with simultaneous potentials and anti-potentials. Proceedings of the 43rd ACM
    SIGPLAN International Conference on Programming Language Design and Implementation.
    PLDI: Programming Language Design and Implementation, 442–457.'
  mla: Zikelic, Dorde, et al. “Differential Cost Analysis with Simultaneous Potentials
    and Anti-Potentials.” <i>Proceedings of the 43rd ACM SIGPLAN International Conference
    on Programming Language Design and Implementation</i>, Association for Computing
    Machinery, 2022, pp. 442–57, doi:<a href="https://doi.org/10.1145/3519939.3523435">10.1145/3519939.3523435</a>.
  short: D. Zikelic, B.-Y.E. Chang, P. Bolignano, F. Raimondi, in:, Proceedings of
    the 43rd ACM SIGPLAN International Conference on Programming Language Design and
    Implementation, Association for Computing Machinery, 2022, pp. 442–457.
conference:
  end_date: 2022-06-17
  location: San Diego, CA, United States
  name: 'PLDI: Programming Language Design and Implementation'
  start_date: 2022-06-13
date_created: 2022-06-21T09:26:15Z
date_published: 2022-06-09T00:00:00Z
date_updated: 2025-07-14T09:09:54Z
day: '09'
ddc:
- '000'
department:
- _id: GradSch
- _id: KrCh
doi: 10.1145/3519939.3523435
ec_funded: 1
external_id:
  arxiv:
  - '2204.00870'
  isi:
  - '000850435600030'
file:
- access_level: open_access
  checksum: 7eb915a2ca5b5ce4729321f33b2e16e1
  content_type: application/pdf
  creator: dernst
  date_created: 2022-06-27T07:38:21Z
  date_updated: 2022-06-27T07:38:21Z
  file_id: '11466'
  file_name: 2022_PLDI_Zikelic.pdf
  file_size: 318697
  relation: main_file
  success: 1
file_date_updated: 2022-06-27T07:38:21Z
has_accepted_license: '1'
isi: 1
language:
- iso: eng
license: https://creativecommons.org/licenses/by-nc-nd/4.0/
month: '06'
oa: 1
oa_version: Published Version
page: 442-457
project:
- _id: 0599E47C-7A3F-11EA-A408-12923DDC885E
  call_identifier: H2020
  grant_number: '863818'
  name: 'Formal Methods for Stochastic Models: Algorithms and Applications'
publication: Proceedings of the 43rd ACM SIGPLAN International Conference on Programming
  Language Design and Implementation
publication_identifier:
  isbn:
  - '9781450392655'
publication_status: published
publisher: Association for Computing Machinery
quality_controlled: '1'
scopus_import: '1'
status: public
title: Differential cost analysis with simultaneous potentials and anti-potentials
tmp:
  image: /images/cc_by_nc_nd.png
  legal_code_url: https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode
  name: Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
    (CC BY-NC-ND 4.0)
  short: CC BY-NC-ND (4.0)
type: conference
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
year: '2022'
...
---
_id: '11460'
abstract:
- lang: eng
  text: "Background: Proper cerebral cortical development depends on the tightly orchestrated
    migration of newly born neurons from the inner ventricular and subventricular
    zones to the outer cortical plate. Any disturbance in this process during prenatal
    stages may lead to neuronal migration disorders (NMDs), which can vary in extent
    from focal to global. Furthermore, NMDs show a substantial comorbidity with other
    neurodevelopmental disorders, notably autism spectrum disorders (ASDs). Our previous
    work demonstrated focal neuronal migration defects in mice carrying loss-of-function
    alleles of the recognized autism risk gene WDFY3. However, the cellular origins
    of these defects in Wdfy3 mutant mice remain elusive and uncovering it will provide
    critical insight into WDFY3-dependent disease pathology.\r\nMethods: Here, in
    an effort to untangle the origins of NMDs in Wdfy3lacZ mice, we employed mosaic
    analysis with double markers (MADM). MADM technology enabled us to genetically
    distinctly track and phenotypically analyze mutant and wild-type cells concomitantly
    in vivo using immunofluorescent techniques.\r\nResults: We revealed a cell autonomous
    requirement of WDFY3 for accurate laminar positioning of cortical projection neurons
    and elimination of mispositioned cells during early postnatal life. In addition,
    we identified significant deviations in dendritic arborization, as well as synaptic
    density and morphology between wild type, heterozygous, and homozygous Wdfy3 mutant
    neurons in Wdfy3-MADM reporter mice at postnatal stages.\r\nLimitations: While
    Wdfy3 mutant mice have provided valuable insight into prenatal aspects of ASD
    pathology that remain inaccessible to investigation in humans, like most animal
    models, they do not a perfectly replicate all aspects of human ASD biology. The
    lack of human data makes it indeterminate whether morphological deviations described
    here apply to ASD patients or some of the other neurodevelopmental conditions
    associated with WDFY3 mutation.\r\nConclusions: Our genetic approach revealed
    several cell autonomous requirements of WDFY3 in neuronal development that could
    underlie the pathogenic mechanisms of WDFY3-related neurodevelopmental conditions.
    The results are also consistent with findings in other ASD animal models and patients
    and suggest an important role for WDFY3 in regulating neuronal function and interconnectivity
    in postnatal life."
acknowledgement: "This study was funded by NIMH R21MH115347 to KSZ. KSZ is further
  supported by Shriners Hospitals for Children.\r\nWe would like to thank Angelo Harlan
  de Crescenzo for early contributions to this project."
article_number: '27'
article_processing_charge: No
article_type: original
author:
- first_name: Zachary A.
  full_name: Schaaf, Zachary A.
  last_name: Schaaf
- first_name: Lyvin
  full_name: Tat, Lyvin
  last_name: Tat
- first_name: Noemi
  full_name: Cannizzaro, Noemi
  last_name: Cannizzaro
- first_name: Ralph
  full_name: Green, Ralph
  last_name: Green
- first_name: Thomas
  full_name: Rülicke, Thomas
  last_name: Rülicke
- first_name: Simon
  full_name: Hippenmeyer, Simon
  id: 37B36620-F248-11E8-B48F-1D18A9856A87
  last_name: Hippenmeyer
  orcid: 0000-0003-2279-1061
- first_name: Konstantinos S.
  full_name: Zarbalis, Konstantinos S.
  last_name: Zarbalis
citation:
  ama: Schaaf ZA, Tat L, Cannizzaro N, et al. WDFY3 mutation alters laminar position
    and morphology of cortical neurons. <i>Molecular Autism</i>. 2022;13. doi:<a href="https://doi.org/10.1186/s13229-022-00508-3">10.1186/s13229-022-00508-3</a>
  apa: Schaaf, Z. A., Tat, L., Cannizzaro, N., Green, R., Rülicke, T., Hippenmeyer,
    S., &#38; Zarbalis, K. S. (2022). WDFY3 mutation alters laminar position and morphology
    of cortical neurons. <i>Molecular Autism</i>. Springer Nature. <a href="https://doi.org/10.1186/s13229-022-00508-3">https://doi.org/10.1186/s13229-022-00508-3</a>
  chicago: Schaaf, Zachary A., Lyvin Tat, Noemi Cannizzaro, Ralph Green, Thomas Rülicke,
    Simon Hippenmeyer, and Konstantinos S. Zarbalis. “WDFY3 Mutation Alters Laminar
    Position and Morphology of Cortical Neurons.” <i>Molecular Autism</i>. Springer
    Nature, 2022. <a href="https://doi.org/10.1186/s13229-022-00508-3">https://doi.org/10.1186/s13229-022-00508-3</a>.
  ieee: Z. A. Schaaf <i>et al.</i>, “WDFY3 mutation alters laminar position and morphology
    of cortical neurons,” <i>Molecular Autism</i>, vol. 13. Springer Nature, 2022.
  ista: Schaaf ZA, Tat L, Cannizzaro N, Green R, Rülicke T, Hippenmeyer S, Zarbalis
    KS. 2022. WDFY3 mutation alters laminar position and morphology of cortical neurons.
    Molecular Autism. 13, 27.
  mla: Schaaf, Zachary A., et al. “WDFY3 Mutation Alters Laminar Position and Morphology
    of Cortical Neurons.” <i>Molecular Autism</i>, vol. 13, 27, Springer Nature, 2022,
    doi:<a href="https://doi.org/10.1186/s13229-022-00508-3">10.1186/s13229-022-00508-3</a>.
  short: Z.A. Schaaf, L. Tat, N. Cannizzaro, R. Green, T. Rülicke, S. Hippenmeyer,
    K.S. Zarbalis, Molecular Autism 13 (2022).
date_created: 2022-06-23T14:28:55Z
date_published: 2022-06-22T00:00:00Z
date_updated: 2023-08-03T07:21:32Z
day: '22'
ddc:
- '570'
department:
- _id: SiHi
doi: 10.1186/s13229-022-00508-3
external_id:
  isi:
  - '000814641400001'
file:
- access_level: open_access
  checksum: 525d2618e855139089bbfc3e3d49d1b2
  content_type: application/pdf
  creator: dernst
  date_created: 2022-06-24T08:22:59Z
  date_updated: 2022-06-24T08:22:59Z
  file_id: '11461'
  file_name: 2022_MolecularAutism_Schaaf.pdf
  file_size: 7552298
  relation: main_file
  success: 1
file_date_updated: 2022-06-24T08:22:59Z
has_accepted_license: '1'
intvolume: '        13'
isi: 1
keyword:
- Psychiatry and Mental health
- Developmental Biology
- Developmental Neuroscience
- Molecular Biology
language:
- iso: eng
month: '06'
oa: 1
oa_version: Published Version
publication: Molecular Autism
publication_identifier:
  issn:
  - 2040-2392
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
related_material:
  link:
  - relation: erratum
    url: https://doi.org/10.1186/s13229-023-00539-4
status: public
title: WDFY3 mutation alters laminar position and morphology of cortical neurons
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 13
year: '2022'
...
---
_id: '11462'
abstract:
- lang: eng
  text: Nanobodies (VHH) from camelid antibody libraries hold great promise as therapeutic
    agents and components of immunoassay systems. Synthetic antibody libraries that
    could be designed and generated once and for various applications could yield
    binders to virtually any targets, even for non-immunogenic or toxic ones, in a
    short term. One of the most difficult tasks is to obtain antibodies with a high
    affinity and specificity to polyglycosylated proteins. It requires antibody libraries
    with extremely high functional diversity and the use of sophisticated selection
    techniques. Here we report a development of a novel sandwich immunoassay involving
    a combination of the synthetic library-derived VHH-Fc fusion protein as a capture
    antibody and the immune single-chain fragment variable (scFv) as a tracer for
    the detection of pregnancy-associated glycoprotein (PAG) of cattle (Bos taurus).
    We succeeded in the generation of a number of specific scFv antibodies against
    PAG from the mouse immune library. Subsequent selection using the immobilized
    scFv-Fc capture antibody allowed to isolate 1.9 nM VHH binder from the diverse
    synthetic library without any overlapping with the capture antibody binding site.
    The prototype sandwich ELISA based on the synthetic VHH and the immune scFv was
    established. This is the first successful example of the combination of synthetic
    and immune antibody libraries in a single sandwich immunoassay. Thus, our approach
    could be used for the express isolation of antibody pairs and the development
    of sandwich immunoassays for challenging antigens.
acknowledgement: This study was financially supported by the State Committee on Science
  and Technology. We would like to thank Elena Tumar and Elena Kisileva at the Institute
  of Bioorganic Chemistry of NASB for their kind assistance with mouse immunizations.
article_processing_charge: No
article_type: original
author:
- first_name: Dmitri
  full_name: Dormeshkin, Dmitri
  last_name: Dormeshkin
- first_name: Michail
  full_name: Shapira, Michail
  last_name: Shapira
- first_name: Alena
  full_name: Karputs, Alena
  last_name: Karputs
- first_name: Anton
  full_name: Kavaleuski, Anton
  id: 62304f89-eb97-11eb-a6c2-8903dd183976
  last_name: Kavaleuski
  orcid: 0000-0003-2091-526X
- first_name: Ivan
  full_name: Kuzminski, Ivan
  last_name: Kuzminski
- first_name: Elena
  full_name: Stepanova, Elena
  last_name: Stepanova
- first_name: Andrei
  full_name: Gilep, Andrei
  last_name: Gilep
citation:
  ama: Dormeshkin D, Shapira M, Karputs A, et al. Combining of synthetic VHH and immune
    scFv libraries for pregnancy-associated glycoproteins ELISA development. <i>Applied
    Microbiology and Biotechnology</i>. 2022;106:5093-5103. doi:<a href="https://doi.org/10.1007/s00253-022-12022-w">10.1007/s00253-022-12022-w</a>
  apa: Dormeshkin, D., Shapira, M., Karputs, A., Kavaleuski, A., Kuzminski, I., Stepanova,
    E., &#38; Gilep, A. (2022). Combining of synthetic VHH and immune scFv libraries
    for pregnancy-associated glycoproteins ELISA development. <i>Applied Microbiology
    and Biotechnology</i>. Springer Nature. <a href="https://doi.org/10.1007/s00253-022-12022-w">https://doi.org/10.1007/s00253-022-12022-w</a>
  chicago: Dormeshkin, Dmitri, Michail Shapira, Alena Karputs, Anton Kavaleuski, Ivan
    Kuzminski, Elena Stepanova, and Andrei Gilep. “Combining of Synthetic VHH and
    Immune ScFv Libraries for Pregnancy-Associated Glycoproteins ELISA Development.”
    <i>Applied Microbiology and Biotechnology</i>. Springer Nature, 2022. <a href="https://doi.org/10.1007/s00253-022-12022-w">https://doi.org/10.1007/s00253-022-12022-w</a>.
  ieee: D. Dormeshkin <i>et al.</i>, “Combining of synthetic VHH and immune scFv libraries
    for pregnancy-associated glycoproteins ELISA development,” <i>Applied Microbiology
    and Biotechnology</i>, vol. 106. Springer Nature, pp. 5093–5103, 2022.
  ista: Dormeshkin D, Shapira M, Karputs A, Kavaleuski A, Kuzminski I, Stepanova E,
    Gilep A. 2022. Combining of synthetic VHH and immune scFv libraries for pregnancy-associated
    glycoproteins ELISA development. Applied Microbiology and Biotechnology. 106,
    5093–5103.
  mla: Dormeshkin, Dmitri, et al. “Combining of Synthetic VHH and Immune ScFv Libraries
    for Pregnancy-Associated Glycoproteins ELISA Development.” <i>Applied Microbiology
    and Biotechnology</i>, vol. 106, Springer Nature, 2022, pp. 5093–103, doi:<a href="https://doi.org/10.1007/s00253-022-12022-w">10.1007/s00253-022-12022-w</a>.
  short: D. Dormeshkin, M. Shapira, A. Karputs, A. Kavaleuski, I. Kuzminski, E. Stepanova,
    A. Gilep, Applied Microbiology and Biotechnology 106 (2022) 5093–5103.
date_created: 2022-06-26T22:01:34Z
date_published: 2022-08-01T00:00:00Z
date_updated: 2023-10-10T07:15:02Z
day: '01'
department:
- _id: GradSch
- _id: LeSa
doi: 10.1007/s00253-022-12022-w
external_id:
  isi:
  - '000813677500001'
  pmid:
  - '35723693'
intvolume: '       106'
isi: 1
language:
- iso: eng
month: '08'
oa_version: None
page: 5093-5103
pmid: 1
publication: Applied Microbiology and Biotechnology
publication_identifier:
  eissn:
  - 1432-0614
  issn:
  - 0175-7598
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
scopus_import: '1'
status: public
title: Combining of synthetic VHH and immune scFv libraries for pregnancy-associated
  glycoproteins ELISA development
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 106
year: '2022'
...
---
_id: '11469'
abstract:
- lang: eng
  text: Thermalizing and localized many-body quantum systems present two distinct
    dynamical phases of matter. Recently the fate of a localized system coupled to
    a thermalizing system viewed as a quantum bath received significant theoretical
    and experimental attention. In this work, we study a mobile impurity, representing
    a small quantum bath, that interacts locally with an Anderson insulator with a
    finite density of localized particles. Using static Hartree approximation to obtain
    an effective disorder strength, we formulate an analytic criterion for the perturbative
    stability of the localization. Next, we use an approximate dynamical Hartree method
    and the quasi-exact time-evolved block decimation (TEBD) algorithm to study the
    dynamics of the system. We find that the dynamical Hartree approach which completely
    ignores entanglement between the impurity and localized particles predicts the
    delocalization of the system. In contrast, the full numerical simulation of the
    unitary dynamics with TEBD suggests the stability of localization on numerically
    accessible timescales. Finally, using an extension of the density matrix renormalization
    group algorithm to excited states (DMRG-X), we approximate the highly excited
    eigenstates of the system. We find that the impurity remains localized in the
    eigenstates and entanglement is enhanced in a finite region around the position
    of the impurity, confirming the dynamical predictions. Dynamics and the DMRG-X
    results provide compelling evidence for the stability of localization.
acknowledged_ssus:
- _id: ScienComp
acknowledgement: We thank M. Ljubotina for insightful discussions. P. B., A. M. and
  M. S. acknowledge support by the European Research Council (ERC) under the European
  Union’s Horizon 2020 research and innovation program (Grant Agreement No. 850899).
  D. A. was supported by the Swiss National Science Foundation and by the European
  Research Council (ERC) under the European Union’s Horizon 2020 research and innovation
  program (Grant Agreement No. 864597). The development of parallel TEBD code was
  supported by S. Elefante from the Scientific Computing (SciComp) that is part of
  Scientific Service Units (SSU) of IST Austria. Some of the computations were performed
  on the Baobab cluster of the University of Geneva.
article_number: '224208'
article_processing_charge: No
article_type: original
arxiv: 1
author:
- first_name: Pietro
  full_name: Brighi, Pietro
  id: 4115AF5C-F248-11E8-B48F-1D18A9856A87
  last_name: Brighi
  orcid: 0000-0002-7969-2729
- first_name: Alexios
  full_name: Michailidis, Alexios
  id: 36EBAD38-F248-11E8-B48F-1D18A9856A87
  last_name: Michailidis
  orcid: 0000-0002-8443-1064
- first_name: Kristina
  full_name: Kirova, Kristina
  id: 4aeda2ae-f847-11ec-98e0-c4a66fe174d4
  last_name: Kirova
- first_name: Dmitry A.
  full_name: Abanin, Dmitry A.
  last_name: Abanin
- first_name: Maksym
  full_name: Serbyn, Maksym
  id: 47809E7E-F248-11E8-B48F-1D18A9856A87
  last_name: Serbyn
  orcid: 0000-0002-2399-5827
citation:
  ama: Brighi P, Michailidis A, Kirova K, Abanin DA, Serbyn M. Localization of a mobile
    impurity interacting with an Anderson insulator. <i>Physical Review B</i>. 2022;105(22).
    doi:<a href="https://doi.org/10.1103/physrevb.105.224208">10.1103/physrevb.105.224208</a>
  apa: Brighi, P., Michailidis, A., Kirova, K., Abanin, D. A., &#38; Serbyn, M. (2022).
    Localization of a mobile impurity interacting with an Anderson insulator. <i>Physical
    Review B</i>. American Physical Society. <a href="https://doi.org/10.1103/physrevb.105.224208">https://doi.org/10.1103/physrevb.105.224208</a>
  chicago: Brighi, Pietro, Alexios Michailidis, Kristina Kirova, Dmitry A. Abanin,
    and Maksym Serbyn. “Localization of a Mobile Impurity Interacting with an Anderson
    Insulator.” <i>Physical Review B</i>. American Physical Society, 2022. <a href="https://doi.org/10.1103/physrevb.105.224208">https://doi.org/10.1103/physrevb.105.224208</a>.
  ieee: P. Brighi, A. Michailidis, K. Kirova, D. A. Abanin, and M. Serbyn, “Localization
    of a mobile impurity interacting with an Anderson insulator,” <i>Physical Review
    B</i>, vol. 105, no. 22. American Physical Society, 2022.
  ista: Brighi P, Michailidis A, Kirova K, Abanin DA, Serbyn M. 2022. Localization
    of a mobile impurity interacting with an Anderson insulator. Physical Review B.
    105(22), 224208.
  mla: Brighi, Pietro, et al. “Localization of a Mobile Impurity Interacting with
    an Anderson Insulator.” <i>Physical Review B</i>, vol. 105, no. 22, 224208, American
    Physical Society, 2022, doi:<a href="https://doi.org/10.1103/physrevb.105.224208">10.1103/physrevb.105.224208</a>.
  short: P. Brighi, A. Michailidis, K. Kirova, D.A. Abanin, M. Serbyn, Physical Review
    B 105 (2022).
date_created: 2022-06-29T20:19:51Z
date_published: 2022-06-27T00:00:00Z
date_updated: 2023-09-05T12:12:52Z
day: '27'
department:
- _id: MaSe
doi: 10.1103/physrevb.105.224208
ec_funded: 1
external_id:
  arxiv:
  - '2111.08603'
  isi:
  - '000823050000001'
intvolume: '       105'
isi: 1
issue: '22'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: ' https://doi.org/10.48550/arXiv.2111.08603 Focus to learn more'
month: '06'
oa: 1
oa_version: Preprint
project:
- _id: 23841C26-32DE-11EA-91FC-C7463DDC885E
  call_identifier: H2020
  grant_number: '850899'
  name: 'Non-Ergodic Quantum Matter: Universality, Dynamics and Control'
publication: Physical Review B
publication_identifier:
  eissn:
  - 2469-9969
  issn:
  - 2469-9950
publication_status: published
publisher: American Physical Society
quality_controlled: '1'
related_material:
  record:
  - id: '12732'
    relation: dissertation_contains
    status: public
status: public
title: Localization of a mobile impurity interacting with an Anderson insulator
type: journal_article
user_id: c635000d-4b10-11ee-a964-aac5a93f6ac1
volume: 105
year: '2022'
...
---
_id: '11470'
abstract:
- lang: eng
  text: Many-body localization (MBL) is an example of a dynamical phase of matter
    that avoids thermalization. While the MBL phase is robust to weak local perturbations,
    the fate of an MBL system coupled to a thermalizing quantum system that represents
    a “heat bath” is an open question that is actively investigated theoretically
    and experimentally. In this work, we consider the stability of an Anderson insulator
    with a finite density of particles interacting with a single mobile impurity—a
    small quantum bath. We give perturbative arguments that support the stability
    of localization in the strong interaction regime. Large-scale tensor network simulations
    of dynamics are employed to corroborate the presence of the localized phase and
    give quantitative predictions in the thermodynamic limit. We develop a phenomenological
    description of the dynamics in the strong interaction regime, and we demonstrate
    that the impurity effectively turns the Anderson insulator into an MBL phase,
    giving rise to nontrivial entanglement dynamics well captured by our phenomenology.
acknowledged_ssus:
- _id: ScienComp
acknowledgement: We acknowledge useful discussions with M. Ljubotina. P. B., A. M.,
  and M. S. were supported by the European Research Council (ERC) under the European
  Union’s Horizon 2020 research and innovation program (Grant Agreement No. 850899).
  D.A. was supported by the Swiss National Science Foundation and by the European
  Research Council (ERC) under the European Union’s Horizon 2020 research and innovation
  program (Grant Agreement No. 864597). The development of parallel TEBD code was
  was supported by S. Elefante from the Scientific Computing (SciComp) that is part
  of Scientific Service Units (SSU) of IST Austria. Some of the computations were
  performed on the Baobab cluster of the University of Geneva.
article_number: L220203
article_processing_charge: No
article_type: original
arxiv: 1
author:
- first_name: Pietro
  full_name: Brighi, Pietro
  id: 4115AF5C-F248-11E8-B48F-1D18A9856A87
  last_name: Brighi
  orcid: 0000-0002-7969-2729
- first_name: Alexios A.
  full_name: Michailidis, Alexios A.
  last_name: Michailidis
- first_name: Dmitry A.
  full_name: Abanin, Dmitry A.
  last_name: Abanin
- first_name: Maksym
  full_name: Serbyn, Maksym
  id: 47809E7E-F248-11E8-B48F-1D18A9856A87
  last_name: Serbyn
  orcid: 0000-0002-2399-5827
citation:
  ama: Brighi P, Michailidis AA, Abanin DA, Serbyn M. Propagation of many-body localization
    in an Anderson insulator. <i>Physical Review B</i>. 2022;105(22). doi:<a href="https://doi.org/10.1103/physrevb.105.l220203">10.1103/physrevb.105.l220203</a>
  apa: Brighi, P., Michailidis, A. A., Abanin, D. A., &#38; Serbyn, M. (2022). Propagation
    of many-body localization in an Anderson insulator. <i>Physical Review B</i>.
    American Physical Society. <a href="https://doi.org/10.1103/physrevb.105.l220203">https://doi.org/10.1103/physrevb.105.l220203</a>
  chicago: Brighi, Pietro, Alexios A. Michailidis, Dmitry A. Abanin, and Maksym Serbyn.
    “Propagation of Many-Body Localization in an Anderson Insulator.” <i>Physical
    Review B</i>. American Physical Society, 2022. <a href="https://doi.org/10.1103/physrevb.105.l220203">https://doi.org/10.1103/physrevb.105.l220203</a>.
  ieee: P. Brighi, A. A. Michailidis, D. A. Abanin, and M. Serbyn, “Propagation of
    many-body localization in an Anderson insulator,” <i>Physical Review B</i>, vol.
    105, no. 22. American Physical Society, 2022.
  ista: Brighi P, Michailidis AA, Abanin DA, Serbyn M. 2022. Propagation of many-body
    localization in an Anderson insulator. Physical Review B. 105(22), L220203.
  mla: Brighi, Pietro, et al. “Propagation of Many-Body Localization in an Anderson
    Insulator.” <i>Physical Review B</i>, vol. 105, no. 22, L220203, American Physical
    Society, 2022, doi:<a href="https://doi.org/10.1103/physrevb.105.l220203">10.1103/physrevb.105.l220203</a>.
  short: P. Brighi, A.A. Michailidis, D.A. Abanin, M. Serbyn, Physical Review B 105
    (2022).
date_created: 2022-06-29T20:20:47Z
date_published: 2022-06-27T00:00:00Z
date_updated: 2023-08-03T07:23:52Z
day: '27'
department:
- _id: MaSe
doi: 10.1103/physrevb.105.l220203
ec_funded: 1
external_id:
  arxiv:
  - '2109.07332'
  isi:
  - '000823050000012'
intvolume: '       105'
isi: 1
issue: '22'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: ' https://doi.org/10.48550/arXiv.2109.07332'
month: '06'
oa: 1
oa_version: Preprint
project:
- _id: 23841C26-32DE-11EA-91FC-C7463DDC885E
  call_identifier: H2020
  grant_number: '850899'
  name: 'Non-Ergodic Quantum Matter: Universality, Dynamics and Control'
publication: Physical Review B
publication_identifier:
  eissn:
  - 2469-9969
  issn:
  - 2469-9950
publication_status: published
publisher: American Physical Society
quality_controlled: '1'
related_material:
  record:
  - id: '12732'
    relation: dissertation_contains
    status: public
status: public
title: Propagation of many-body localization in an Anderson insulator
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 105
year: '2022'
...
---
_id: '11471'
abstract:
- lang: eng
  text: 'Variational quantum algorithms are promising algorithms for achieving quantum
    advantage on nearterm devices. The quantum hardware is used to implement a variational
    wave function and measure observables, whereas the classical computer is used
    to store and update the variational parameters. The optimization landscape of
    expressive variational ansätze is however dominated by large regions in parameter
    space, known as barren plateaus, with vanishing gradients, which prevents efficient
    optimization. In this work we propose a general algorithm to avoid barren plateaus
    in the initialization and throughout the optimization. To this end we define a
    notion of weak barren plateaus (WBPs) based on the entropies of local reduced
    density matrices. The presence of WBPs can be efficiently quantified using recently
    introduced shadow tomography of the quantum state with a classical computer. We
    demonstrate that avoidance of WBPs suffices to ensure sizable gradients in the
    initialization. In addition, we demonstrate that decreasing the gradient step
    size, guided by the entropies allows WBPs to be avoided during the optimization
    process. This paves the way for efficient barren plateau-free optimization on
    near-term devices. '
acknowledgement: "We thank Marco Cerezo, Zoe Holmes, and Nicholas Hunter-Jones for
  fruitful discussion and valuable feedback. We also acknowledge Adam Smith, Johannes
  Jakob Meyer, and Victor V. Albert for comments on the paper. The simulations were
  performed in the Julia programming\r\nlanguage [65] using the Yao module [66]. S.H.S.,
  R.A.M., A.A.M. and M.S. acknowledge support by the European Research Council (ERC)
  under the European Union’s Horizon 2020 research and innovation program (Grant Agreement
  No. 850899)."
article_number: '020365'
article_processing_charge: No
article_type: original
arxiv: 1
author:
- first_name: Stefan
  full_name: Sack, Stefan
  id: dd622248-f6e0-11ea-865d-ce382a1c81a5
  last_name: Sack
  orcid: 0000-0001-5400-8508
- first_name: Raimel A
  full_name: Medina Ramos, Raimel A
  id: CE680B90-D85A-11E9-B684-C920E6697425
  last_name: Medina Ramos
  orcid: 0000-0002-5383-2869
- first_name: Alexios
  full_name: Michailidis, Alexios
  id: 36EBAD38-F248-11E8-B48F-1D18A9856A87
  last_name: Michailidis
  orcid: 0000-0002-8443-1064
- first_name: Richard
  full_name: Kueng, Richard
  last_name: Kueng
- first_name: Maksym
  full_name: Serbyn, Maksym
  id: 47809E7E-F248-11E8-B48F-1D18A9856A87
  last_name: Serbyn
  orcid: 0000-0002-2399-5827
citation:
  ama: Sack S, Medina Ramos RA, Michailidis A, Kueng R, Serbyn M. Avoiding barren
    plateaus using classical shadows. <i>PRX Quantum</i>. 2022;3(2). doi:<a href="https://doi.org/10.1103/prxquantum.3.020365">10.1103/prxquantum.3.020365</a>
  apa: Sack, S., Medina Ramos, R. A., Michailidis, A., Kueng, R., &#38; Serbyn, M.
    (2022). Avoiding barren plateaus using classical shadows. <i>PRX Quantum</i>.
    American Physical Society. <a href="https://doi.org/10.1103/prxquantum.3.020365">https://doi.org/10.1103/prxquantum.3.020365</a>
  chicago: Sack, Stefan, Raimel A Medina Ramos, Alexios Michailidis, Richard Kueng,
    and Maksym Serbyn. “Avoiding Barren Plateaus Using Classical Shadows.” <i>PRX
    Quantum</i>. American Physical Society, 2022. <a href="https://doi.org/10.1103/prxquantum.3.020365">https://doi.org/10.1103/prxquantum.3.020365</a>.
  ieee: S. Sack, R. A. Medina Ramos, A. Michailidis, R. Kueng, and M. Serbyn, “Avoiding
    barren plateaus using classical shadows,” <i>PRX Quantum</i>, vol. 3, no. 2. American
    Physical Society, 2022.
  ista: Sack S, Medina Ramos RA, Michailidis A, Kueng R, Serbyn M. 2022. Avoiding
    barren plateaus using classical shadows. PRX Quantum. 3(2), 020365.
  mla: Sack, Stefan, et al. “Avoiding Barren Plateaus Using Classical Shadows.” <i>PRX
    Quantum</i>, vol. 3, no. 2, 020365, American Physical Society, 2022, doi:<a href="https://doi.org/10.1103/prxquantum.3.020365">10.1103/prxquantum.3.020365</a>.
  short: S. Sack, R.A. Medina Ramos, A. Michailidis, R. Kueng, M. Serbyn, PRX Quantum
    3 (2022).
date_created: 2022-06-29T20:21:32Z
date_published: 2022-06-29T00:00:00Z
date_updated: 2023-12-13T14:47:24Z
day: '29'
ddc:
- '530'
department:
- _id: MaSe
doi: 10.1103/prxquantum.3.020365
ec_funded: 1
external_id:
  arxiv:
  - '2201.08194'
  isi:
  - '000822564300001'
file:
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  content_type: application/pdf
  creator: dernst
  date_created: 2022-06-30T07:14:48Z
  date_updated: 2022-06-30T07:14:48Z
  file_id: '11472'
  file_name: 2022_PRXQuantum_Sack.pdf
  file_size: 4231591
  relation: main_file
  success: 1
file_date_updated: 2022-06-30T07:14:48Z
has_accepted_license: '1'
intvolume: '         3'
isi: 1
issue: '2'
keyword:
- General Medicine
language:
- iso: eng
month: '06'
oa: 1
oa_version: Published Version
project:
- _id: 23841C26-32DE-11EA-91FC-C7463DDC885E
  call_identifier: H2020
  grant_number: '850899'
  name: 'Non-Ergodic Quantum Matter: Universality, Dynamics and Control'
publication: PRX Quantum
publication_identifier:
  issn:
  - 2691-3399
publication_status: published
publisher: American Physical Society
quality_controlled: '1'
related_material:
  record:
  - id: '14622'
    relation: dissertation_contains
    status: public
status: public
title: Avoiding barren plateaus using classical shadows
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 3
year: '2022'
...
---
_id: '11473'
abstract:
- lang: eng
  text: "The polaron model is a basic model of quantum field theory describing a single
    particle\r\ninteracting with a bosonic field. It arises in many physical contexts.
    We are mostly concerned\r\nwith models applicable in the context of an impurity
    atom in a Bose-Einstein condensate as\r\nwell as the problem of electrons moving
    in polar crystals.\r\nThe model has a simple structure in which the interaction
    of the particle with the field is given\r\nby a term linear in the field’s creation
    and annihilation operators. In this work, we investigate\r\nthe properties of
    this model by providing rigorous estimates on various energies relevant to the\r\nproblem.
    The estimates are obtained, for the most part, by suitable operator techniques
    which\r\nconstitute the principal mathematical substance of the thesis.\r\nThe
    first application of these techniques is to derive the polaron model rigorously
    from first\r\nprinciples, i.e., from a full microscopic quantum-mechanical many-body
    problem involving an\r\nimpurity in an otherwise homogeneous system. We accomplish
    this for the N + 1 Bose gas\r\nin the mean-field regime by showing that a suitable
    polaron-type Hamiltonian arises at weak\r\ninteractions as a low-energy effective
    theory for this problem.\r\nIn the second part, we investigate rigorously the
    ground state of the model at fixed momentum\r\nand for large values of the coupling
    constant. Qualitatively, the system is expected to display\r\na transition from
    the quasi-particle behavior at small momenta, where the dispersion relation\r\nis
    parabolic and the particle moves through the medium dragging along a cloud of
    phonons, to\r\nthe radiative behavior at larger momenta where the polaron decelerates
    and emits free phonons.\r\nAt the same time, in the strong coupling regime, the
    bosonic field is expected to behave purely\r\nclassically. Accordingly, the effective
    mass of the polaron at strong coupling is conjectured to\r\nbe asymptotically
    equal to the one obtained from the semiclassical counterpart of the problem,\r\nfirst
    studied by Landau and Pekar in the 1940s. For polaron models with regularized
    form\r\nfactors and phonon dispersion relations of superfluid type, i.e., bounded
    below by a linear\r\nfunction of the wavenumbers for all phonon momenta as in
    the interacting Bose gas, we prove\r\nthat for a large window of momenta below
    the radiation threshold, the energy-momentum\r\nrelation at strong coupling is
    indeed essentially a parabola with semi-latus rectum equal to the\r\nLandau–Pekar
    effective mass, as expected.\r\nFor the Fröhlich polaron describing electrons
    in polar crystals where the dispersion relation is\r\nof the optical type and
    the form factor is formally UV–singular due to the nature of the point\r\ncharge-dipole
    interaction, we are able to give the corresponding upper bound. In contrast to\r\nthe
    regular case, this requires the inclusion of the quantum fluctuations of the phonon
    field,\r\nwhich makes the problem considerably more difficult.\r\nThe results
    are supplemented by studies on the absolute ground-state energy at strong coupling,\r\na
    proof of the divergence of the effective mass with the coupling constant for a
    wide class of\r\npolaron models, as well as the discussion of the apparent UV
    singularity of the Fröhlich model\r\nand the application of the techniques used
    for its removal for the energy estimates.\r\n"
acknowledged_ssus:
- _id: SSU
alternative_title:
- ISTA Thesis
article_processing_charge: No
author:
- first_name: Krzysztof
  full_name: Mysliwy, Krzysztof
  id: 316457FC-F248-11E8-B48F-1D18A9856A87
  last_name: Mysliwy
citation:
  ama: 'Mysliwy K. Polarons in Bose gases and polar crystals: Some rigorous energy
    estimates. 2022. doi:<a href="https://doi.org/10.15479/at:ista:11473">10.15479/at:ista:11473</a>'
  apa: 'Mysliwy, K. (2022). <i>Polarons in Bose gases and polar crystals: Some rigorous
    energy estimates</i>. Institute of Science and Technology Austria. <a href="https://doi.org/10.15479/at:ista:11473">https://doi.org/10.15479/at:ista:11473</a>'
  chicago: 'Mysliwy, Krzysztof. “Polarons in Bose Gases and Polar Crystals: Some Rigorous
    Energy Estimates.” Institute of Science and Technology Austria, 2022. <a href="https://doi.org/10.15479/at:ista:11473">https://doi.org/10.15479/at:ista:11473</a>.'
  ieee: 'K. Mysliwy, “Polarons in Bose gases and polar crystals: Some rigorous energy
    estimates,” Institute of Science and Technology Austria, 2022.'
  ista: 'Mysliwy K. 2022. Polarons in Bose gases and polar crystals: Some rigorous
    energy estimates. Institute of Science and Technology Austria.'
  mla: 'Mysliwy, Krzysztof. <i>Polarons in Bose Gases and Polar Crystals: Some Rigorous
    Energy Estimates</i>. Institute of Science and Technology Austria, 2022, doi:<a
    href="https://doi.org/10.15479/at:ista:11473">10.15479/at:ista:11473</a>.'
  short: 'K. Mysliwy, Polarons in Bose Gases and Polar Crystals: Some Rigorous Energy
    Estimates, Institute of Science and Technology Austria, 2022.'
date_created: 2022-06-30T12:15:03Z
date_published: 2022-07-01T00:00:00Z
date_updated: 2023-09-07T13:43:52Z
day: '01'
ddc:
- '515'
- '539'
degree_awarded: PhD
department:
- _id: GradSch
- _id: RoSe
doi: 10.15479/at:ista:11473
ec_funded: 1
file:
- access_level: open_access
  checksum: 7970714a20a6052f75fb27a6c3e9976e
  content_type: application/pdf
  creator: kmysliwy
  date_created: 2022-07-05T08:12:56Z
  date_updated: 2022-07-05T08:12:56Z
  file_id: '11486'
  file_name: thes1_no_isbn_2_1b.pdf
  file_size: 1830973
  relation: main_file
  success: 1
- access_level: closed
  checksum: 647a2011fdf56277096c9350fefe1097
  content_type: application/zip
  creator: kmysliwy
  date_created: 2022-07-05T08:15:52Z
  date_updated: 2022-07-05T08:17:12Z
  file_id: '11487'
  file_name: thes_source.zip
  file_size: 5831060
  relation: source_file
file_date_updated: 2022-07-05T08:17:12Z
has_accepted_license: '1'
language:
- iso: eng
month: '07'
oa: 1
oa_version: Published Version
page: '138'
project:
- _id: 2564DBCA-B435-11E9-9278-68D0E5697425
  call_identifier: H2020
  grant_number: '665385'
  name: International IST Doctoral Program
publication_identifier:
  issn:
  - 2663-337X
publication_status: published
publisher: Institute of Science and Technology Austria
related_material:
  record:
  - id: '10564'
    relation: part_of_dissertation
    status: public
  - id: '8705'
    relation: part_of_dissertation
    status: public
status: public
supervisor:
- first_name: Robert
  full_name: Seiringer, Robert
  id: 4AFD0470-F248-11E8-B48F-1D18A9856A87
  last_name: Seiringer
  orcid: 0000-0002-6781-0521
title: 'Polarons in Bose gases and polar crystals: Some rigorous energy estimates'
type: dissertation
user_id: c635000d-4b10-11ee-a964-aac5a93f6ac1
year: '2022'
...
---
_id: '11476'
abstract:
- lang: eng
  text: "Messaging platforms like Signal are widely deployed and provide strong security
    in an asynchronous setting. It is a challenging problem to construct a protocol
    with similar security guarantees that can efficiently scale to large groups. A
    major bottleneck are the frequent key rotations users need to perform to achieve
    post compromise forward security.\r\n\r\nIn current proposals – most notably in
    TreeKEM (which is part of the IETF’s Messaging Layer Security (MLS) protocol draft)
    – for users in a group of size n to rotate their keys, they must each craft a
    message of size log(n) to be broadcast to the group using an (untrusted) delivery
    server.\r\n\r\nIn larger groups, having users sequentially rotate their keys requires
    too much bandwidth (or takes too long), so variants allowing any T≤n users to
    simultaneously rotate their keys in just 2 communication rounds have been suggested
    (e.g. “Propose and Commit” by MLS). Unfortunately, 2-round concurrent updates
    are either damaging or expensive (or both); i.e. they either result in future
    operations being more costly (e.g. via “blanking” or “tainting”) or are costly
    themselves requiring Ω(T) communication for each user [Bienstock et al., TCC’20].\r\n\r\nIn
    this paper we propose CoCoA; a new scheme that allows for T concurrent updates
    that are neither damaging nor costly. That is, they add no cost to future operations
    yet they only require Ω(log2(n)) communication per user. To circumvent the [Bienstock
    et al.] lower bound, CoCoA increases the number of rounds needed to complete all
    updates from 2 up to (at most) log(n); though typically fewer rounds are needed.\r\n\r\nThe
    key insight of our protocol is the following: in the (non-concurrent version of)
    TreeKEM, a delivery server which gets T concurrent update requests will approve
    one and reject the remaining T−1. In contrast, our server attempts to apply all
    of them. If more than one user requests to rotate the same key during a round,
    the server arbitrarily picks a winner. Surprisingly, we prove that regardless
    of how the server chooses the winners, all previously compromised users will recover
    after at most log(n) such update rounds.\r\n\r\nTo keep the communication complexity
    low, CoCoA is a server-aided CGKA. That is, the delivery server no longer blindly
    forwards packets, but instead actively computes individualized packets tailored
    to each user. As the server is untrusted, this change requires us to develop new
    mechanisms ensuring robustness of the protocol."
acknowledgement: We thank Marta Mularczyk and Yiannis Tselekounis for their very helpful
  feedback on an earlier draft of this paper.
alternative_title:
- LNCS
article_processing_charge: No
author:
- first_name: Joël
  full_name: Alwen, Joël
  last_name: Alwen
- first_name: Benedikt
  full_name: Auerbach, Benedikt
  id: D33D2B18-E445-11E9-ABB7-15F4E5697425
  last_name: Auerbach
  orcid: 0000-0002-7553-6606
- first_name: Miguel
  full_name: Cueto Noval, Miguel
  id: ffc563a3-f6e0-11ea-865d-e3cce03d17cc
  last_name: Cueto Noval
- first_name: Karen
  full_name: Klein, Karen
  id: 3E83A2F8-F248-11E8-B48F-1D18A9856A87
  last_name: Klein
- first_name: Guillermo
  full_name: Pascual Perez, Guillermo
  id: 2D7ABD02-F248-11E8-B48F-1D18A9856A87
  last_name: Pascual Perez
- first_name: Krzysztof Z
  full_name: Pietrzak, Krzysztof Z
  id: 3E04A7AA-F248-11E8-B48F-1D18A9856A87
  last_name: Pietrzak
  orcid: 0000-0002-9139-1654
- first_name: Michael
  full_name: Walter, Michael
  last_name: Walter
citation:
  ama: 'Alwen J, Auerbach B, Cueto Noval M, et al. CoCoA: Concurrent continuous group
    key agreement. In: <i>Advances in Cryptology – EUROCRYPT 2022</i>. Vol 13276.
    Cham: Springer Nature; 2022:815–844. doi:<a href="https://doi.org/10.1007/978-3-031-07085-3_28">10.1007/978-3-031-07085-3_28</a>'
  apa: 'Alwen, J., Auerbach, B., Cueto Noval, M., Klein, K., Pascual Perez, G., Pietrzak,
    K. Z., &#38; Walter, M. (2022). CoCoA: Concurrent continuous group key agreement.
    In <i>Advances in Cryptology – EUROCRYPT 2022</i> (Vol. 13276, pp. 815–844). Cham:
    Springer Nature. <a href="https://doi.org/10.1007/978-3-031-07085-3_28">https://doi.org/10.1007/978-3-031-07085-3_28</a>'
  chicago: 'Alwen, Joël, Benedikt Auerbach, Miguel Cueto Noval, Karen Klein, Guillermo
    Pascual Perez, Krzysztof Z Pietrzak, and Michael Walter. “CoCoA: Concurrent Continuous
    Group Key Agreement.” In <i>Advances in Cryptology – EUROCRYPT 2022</i>, 13276:815–844.
    Cham: Springer Nature, 2022. <a href="https://doi.org/10.1007/978-3-031-07085-3_28">https://doi.org/10.1007/978-3-031-07085-3_28</a>.'
  ieee: 'J. Alwen <i>et al.</i>, “CoCoA: Concurrent continuous group key agreement,”
    in <i>Advances in Cryptology – EUROCRYPT 2022</i>, Trondheim, Norway, 2022, vol.
    13276, pp. 815–844.'
  ista: 'Alwen J, Auerbach B, Cueto Noval M, Klein K, Pascual Perez G, Pietrzak KZ,
    Walter M. 2022. CoCoA: Concurrent continuous group key agreement. Advances in
    Cryptology – EUROCRYPT 2022. EUROCRYPT: Annual International Conference on the
    Theory and Applications of Cryptology and Information Security, LNCS, vol. 13276,
    815–844.'
  mla: 'Alwen, Joël, et al. “CoCoA: Concurrent Continuous Group Key Agreement.” <i>Advances
    in Cryptology – EUROCRYPT 2022</i>, vol. 13276, Springer Nature, 2022, pp. 815–844,
    doi:<a href="https://doi.org/10.1007/978-3-031-07085-3_28">10.1007/978-3-031-07085-3_28</a>.'
  short: J. Alwen, B. Auerbach, M. Cueto Noval, K. Klein, G. Pascual Perez, K.Z. Pietrzak,
    M. Walter, in:, Advances in Cryptology – EUROCRYPT 2022, Springer Nature, Cham,
    2022, pp. 815–844.
conference:
  end_date: 2022-06-03
  location: Trondheim, Norway
  name: 'EUROCRYPT: Annual International Conference on the Theory and Applications
    of Cryptology and Information Security'
  start_date: 2022-05-30
date_created: 2022-06-30T16:48:00Z
date_published: 2022-05-25T00:00:00Z
date_updated: 2023-08-03T07:25:02Z
day: '25'
department:
- _id: GradSch
- _id: KrPi
doi: 10.1007/978-3-031-07085-3_28
ec_funded: 1
external_id:
  isi:
  - '000832305300028'
intvolume: '     13276'
isi: 1
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://eprint.iacr.org/2022/251
month: '05'
oa: 1
oa_version: Preprint
page: 815–844
place: Cham
project:
- _id: 258AA5B2-B435-11E9-9278-68D0E5697425
  call_identifier: H2020
  grant_number: '682815'
  name: Teaching Old Crypto New Tricks
- _id: 2564DBCA-B435-11E9-9278-68D0E5697425
  call_identifier: H2020
  grant_number: '665385'
  name: International IST Doctoral Program
publication: Advances in Cryptology – EUROCRYPT 2022
publication_identifier:
  eisbn:
  - '9783031070853'
  eissn:
  - 1611-3349
  isbn:
  - '9783031070846'
  issn:
  - 0302-9743
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
scopus_import: '1'
status: public
title: 'CoCoA: Concurrent continuous group key agreement'
type: conference
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 13276
year: '2022'
...
---
_id: '11478'
abstract:
- lang: eng
  text: Cerebral organoids differentiated from human-induced pluripotent stem cells
    (hiPSC) provide a unique opportunity to investigate brain development. However,
    organoids usually lack microglia, brain-resident immune cells, which are present
    in the early embryonic brain and participate in neuronal circuit development.
    Here, we find IBA1+ microglia-like cells alongside retinal cups between week 3
    and 4 in 2.5D culture with an unguided retinal organoid differentiation protocol.
    Microglia do not infiltrate the neuroectoderm and instead enrich within non-pigmented,
    3D-cystic compartments that develop in parallel to the 3D-retinal organoids. When
    we guide the retinal organoid differentiation with low-dosed BMP4, we prevent
    cup development and enhance microglia and 3D-cysts formation. Mass spectrometry
    identifies these 3D-cysts to express mesenchymal and epithelial markers. We confirmed
    this microglia-preferred environment also within the unguided protocol, providing
    insight into microglial behavior and migration and offer a model to study how
    they enter and distribute within the human brain.
acknowledged_ssus:
- _id: Bio
- _id: LifeSc
acknowledgement: We thank the scientific service units at ISTA, specifically the lab
  support facility and imaging & optics facility for their support; Nicolas Armel
  for performing the Mass Spectrometry. We thank Alexandra Lang and Tanja Peilnsteiner
  for their help in human brain tissue collection, Rouven Schulz for his insights
  into the functional assays We thank all members of the Siegert group for constant
  feedback on the project and Margaret Maes, Rouven Schulz, and Marco Benevento for
  feedback on the manuscript. This project has received funding from the European
  Research Council (ERC) under the European Union’s Horizon 2020 research and innovation
  program (grant No. 715571 to S.S.) and from the Gesellschaft für Forschungsförderung
  Niederösterreich (grant No. Sc19-017 to V.H.).
article_number: '104580'
article_processing_charge: Yes
article_type: original
author:
- first_name: Katarina
  full_name: Bartalska, Katarina
  id: 4D883232-F248-11E8-B48F-1D18A9856A87
  last_name: Bartalska
- first_name: Verena
  full_name: Hübschmann, Verena
  id: 32B7C918-F248-11E8-B48F-1D18A9856A87
  last_name: Hübschmann
- first_name: Medina
  full_name: Korkut, Medina
  id: 4B51CE74-F248-11E8-B48F-1D18A9856A87
  last_name: Korkut
  orcid: 0000-0003-4309-2251
- first_name: Ryan J
  full_name: Cubero, Ryan J
  id: 850B2E12-9CD4-11E9-837F-E719E6697425
  last_name: Cubero
  orcid: 0000-0003-0002-1867
- first_name: Alessandro
  full_name: Venturino, Alessandro
  id: 41CB84B2-F248-11E8-B48F-1D18A9856A87
  last_name: Venturino
  orcid: 0000-0003-2356-9403
- first_name: Karl
  full_name: Rössler, Karl
  last_name: Rössler
- first_name: Thomas
  full_name: Czech, Thomas
  last_name: Czech
- first_name: Sandra
  full_name: Siegert, Sandra
  id: 36ACD32E-F248-11E8-B48F-1D18A9856A87
  last_name: Siegert
  orcid: 0000-0001-8635-0877
citation:
  ama: Bartalska K, Hübschmann V, Korkut M, et al. A systematic characterization of
    microglia-like cell occurrence during retinal organoid differentiation. <i>iScience</i>.
    2022;25(7). doi:<a href="https://doi.org/10.1016/j.isci.2022.104580">10.1016/j.isci.2022.104580</a>
  apa: Bartalska, K., Hübschmann, V., Korkut, M., Cubero, R. J., Venturino, A., Rössler,
    K., … Siegert, S. (2022). A systematic characterization of microglia-like cell
    occurrence during retinal organoid differentiation. <i>IScience</i>. Elsevier.
    <a href="https://doi.org/10.1016/j.isci.2022.104580">https://doi.org/10.1016/j.isci.2022.104580</a>
  chicago: Bartalska, Katarina, Verena Hübschmann, Medina Korkut, Ryan J Cubero, Alessandro
    Venturino, Karl Rössler, Thomas Czech, and Sandra Siegert. “A Systematic Characterization
    of Microglia-like Cell Occurrence during Retinal Organoid Differentiation.” <i>IScience</i>.
    Elsevier, 2022. <a href="https://doi.org/10.1016/j.isci.2022.104580">https://doi.org/10.1016/j.isci.2022.104580</a>.
  ieee: K. Bartalska <i>et al.</i>, “A systematic characterization of microglia-like
    cell occurrence during retinal organoid differentiation,” <i>iScience</i>, vol.
    25, no. 7. Elsevier, 2022.
  ista: Bartalska K, Hübschmann V, Korkut M, Cubero RJ, Venturino A, Rössler K, Czech
    T, Siegert S. 2022. A systematic characterization of microglia-like cell occurrence
    during retinal organoid differentiation. iScience. 25(7), 104580.
  mla: Bartalska, Katarina, et al. “A Systematic Characterization of Microglia-like
    Cell Occurrence during Retinal Organoid Differentiation.” <i>IScience</i>, vol.
    25, no. 7, 104580, Elsevier, 2022, doi:<a href="https://doi.org/10.1016/j.isci.2022.104580">10.1016/j.isci.2022.104580</a>.
  short: K. Bartalska, V. Hübschmann, M. Korkut, R.J. Cubero, A. Venturino, K. Rössler,
    T. Czech, S. Siegert, IScience 25 (2022).
date_created: 2022-07-03T22:01:33Z
date_published: 2022-07-15T00:00:00Z
date_updated: 2023-11-02T12:21:33Z
day: '15'
ddc:
- '610'
department:
- _id: SaSi
doi: 10.1016/j.isci.2022.104580
ec_funded: 1
external_id:
  isi:
  - '000830428500005'
file:
- access_level: open_access
  checksum: a470b74e1b3796c710189c81a4cd4329
  content_type: application/pdf
  creator: cchlebak
  date_created: 2022-07-04T08:19:25Z
  date_updated: 2022-07-04T08:19:25Z
  file_id: '11480'
  file_name: 2022_iScience_Bartalska.pdf
  file_size: 19400048
  relation: main_file
  success: 1
file_date_updated: 2022-07-04T08:19:25Z
has_accepted_license: '1'
intvolume: '        25'
isi: 1
issue: '7'
language:
- iso: eng
month: '07'
oa: 1
oa_version: Published Version
project:
- _id: 25D4A630-B435-11E9-9278-68D0E5697425
  call_identifier: H2020
  grant_number: '715571'
  name: Microglia action towards neuronal circuit formation and function in health
    and disease
- _id: B67AFEDC-15C9-11EA-A837-991A96BB2854
  name: IST Austria Open Access Fund
- _id: 9B99D380-BA93-11EA-9121-9846C619BF3A
  grant_number: SC19-017
  name: How human microglia shape developing neurons during health and inflammation
publication: iScience
publication_identifier:
  eissn:
  - 2589-0042
publication_status: published
publisher: Elsevier
quality_controlled: '1'
related_material:
  record:
  - id: '12117'
    relation: other
    status: public
scopus_import: '1'
status: public
title: A systematic characterization of microglia-like cell occurrence during retinal
  organoid differentiation
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: 3E5EF7F0-F248-11E8-B48F-1D18A9856A87
volume: 25
year: '2022'
...
---
_id: '11489'
abstract:
- lang: eng
  text: Much of plant development depends on cell-to-cell redistribution of the plant
    hormone auxin, which is facilitated by the plasma membrane (PM) localized PIN
    FORMED (PIN) proteins. Auxin export activity, developmental roles, subcellular
    trafficking, and polarity of PINs have been well studied, but their structure
    remains elusive besides a rough outline that they contain two groups of 5 alpha-helices
    connected by a large hydrophilic loop (HL). Here, we focus on the PIN1 HL as we
    could produce it in sufficient quantities for biochemical investigations to provide
    insights into its secondary structure. Circular dichroism (CD) studies revealed
    its nature as an intrinsically disordered protein (IDP), manifested by the increase
    of structure content upon thermal melting. Consistent with IDPs serving as interaction
    platforms, PIN1 loops homodimerize. PIN1 HL cytoplasmic overexpression in Arabidopsis
    disrupts early endocytic trafficking of PIN1 and PIN2 and causes defects in the
    cotyledon vasculature formation. In summary, we demonstrate that PIN1 HL has an
    intrinsically disordered nature, which must be considered to gain further structural
    insights. Some secondary structures may form transiently during pairing with known
    and yet-to-be-discovered interactors.
acknowledgement: 'We thank Charo del Genio from Coventry University and Richard Napier
  from the University of Warwick for helpful discussion concerning protein modeling
  and inspiration concerning CD spectroscopy, respectively. We thank Jan Hejatko for
  sharing the published AHP2 construct. We also thank Josef Houser from the core facility
  BIC CEITEC for valuable assistance, discussions, and ideas relating to CD. We acknowledge
  the: Core Facility CELLIM of CEITEC supported by the Czech-BioImaging large RI project
  (LM2018129 funded by MEYS CR), part of the Euro-BioImaging (www.eurobioimaging.eu
  accessed on 1 January 2016) ALM and medical imaging Node (Brno, CZ), CF Biomolecular
  Interactions and Crystallization of CIISB, Instruct-CZ Centre, supported by MEYS
  CR (LM2018127) and European Regional Development Fund-Project “UP CIISB“ (No. CZ.02.1.01/0.0/0.0/18_046/0015974)
  for their support with obtaining scientific data presented in this paper; Plant
  Sciences Core Facility of CEITEC Masaryk University for technical support. Open
  Access Funding by the Austrian Science Fund (FWF).'
article_processing_charge: Yes
article_type: original
author:
- first_name: V
  full_name: Bilanovičová, V
  last_name: Bilanovičová
- first_name: N
  full_name: Rýdza, N
  last_name: Rýdza
- first_name: L
  full_name: Koczka, L
  last_name: Koczka
- first_name: M
  full_name: Hess, M
  last_name: Hess
- first_name: E
  full_name: Feraru, E
  last_name: Feraru
- first_name: Jiří
  full_name: Friml, Jiří
  id: 4159519E-F248-11E8-B48F-1D18A9856A87
  last_name: Friml
  orcid: 0000-0002-8302-7596
- first_name: T
  full_name: Nodzyński, T
  last_name: Nodzyński
citation:
  ama: Bilanovičová V, Rýdza N, Koczka L, et al. The hydrophilic loop of Arabidopsis
    PIN1 auxin efflux carrier harbors hallmarks of an intrinsically disordered protein.
    <i>International Journal of Molecular Sciences</i>. 2022;23(11):6352. doi:<a href="https://doi.org/10.3390/ijms23116352">10.3390/ijms23116352</a>
  apa: Bilanovičová, V., Rýdza, N., Koczka, L., Hess, M., Feraru, E., Friml, J., &#38;
    Nodzyński, T. (2022). The hydrophilic loop of Arabidopsis PIN1 auxin efflux carrier
    harbors hallmarks of an intrinsically disordered protein. <i>International Journal
    of Molecular Sciences</i>. MDPI. <a href="https://doi.org/10.3390/ijms23116352">https://doi.org/10.3390/ijms23116352</a>
  chicago: Bilanovičová, V, N Rýdza, L Koczka, M Hess, E Feraru, Jiří Friml, and T
    Nodzyński. “The Hydrophilic Loop of Arabidopsis PIN1 Auxin Efflux Carrier Harbors
    Hallmarks of an Intrinsically Disordered Protein.” <i>International Journal of
    Molecular Sciences</i>. MDPI, 2022. <a href="https://doi.org/10.3390/ijms23116352">https://doi.org/10.3390/ijms23116352</a>.
  ieee: V. Bilanovičová <i>et al.</i>, “The hydrophilic loop of Arabidopsis PIN1 auxin
    efflux carrier harbors hallmarks of an intrinsically disordered protein,” <i>International
    Journal of Molecular Sciences</i>, vol. 23, no. 11. MDPI, p. 6352, 2022.
  ista: Bilanovičová V, Rýdza N, Koczka L, Hess M, Feraru E, Friml J, Nodzyński T.
    2022. The hydrophilic loop of Arabidopsis PIN1 auxin efflux carrier harbors hallmarks
    of an intrinsically disordered protein. International Journal of Molecular Sciences.
    23(11), 6352.
  mla: Bilanovičová, V., et al. “The Hydrophilic Loop of Arabidopsis PIN1 Auxin Efflux
    Carrier Harbors Hallmarks of an Intrinsically Disordered Protein.” <i>International
    Journal of Molecular Sciences</i>, vol. 23, no. 11, MDPI, 2022, p. 6352, doi:<a
    href="https://doi.org/10.3390/ijms23116352">10.3390/ijms23116352</a>.
  short: V. Bilanovičová, N. Rýdza, L. Koczka, M. Hess, E. Feraru, J. Friml, T. Nodzyński,
    International Journal of Molecular Sciences 23 (2022) 6352.
date_created: 2022-07-05T15:14:34Z
date_published: 2022-06-06T00:00:00Z
date_updated: 2023-08-09T10:13:57Z
day: '06'
ddc:
- '570'
department:
- _id: JiFr
doi: 10.3390/ijms23116352
external_id:
  isi:
  - '000808733300001'
  pmid:
  - '35683031'
file:
- access_level: open_access
  checksum: e997a57a928ec9d51fad8ce824a05935
  content_type: application/pdf
  creator: cchlebak
  date_created: 2022-07-06T07:36:59Z
  date_updated: 2022-07-06T07:36:59Z
  file_id: '11492'
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  file_size: 2324542
  relation: main_file
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file_date_updated: 2022-07-06T07:36:59Z
has_accepted_license: '1'
intvolume: '        23'
isi: 1
issue: '11'
language:
- iso: eng
month: '06'
oa: 1
oa_version: Published Version
page: '6352'
pmid: 1
project:
- _id: 262EF96E-B435-11E9-9278-68D0E5697425
  call_identifier: FWF
  grant_number: P29988
  name: RNA-directed DNA methylation in plant development
publication: International Journal of Molecular Sciences
publication_identifier:
  issn:
  - 1422-0067
publication_status: published
publisher: MDPI
quality_controlled: '1'
status: public
title: The hydrophilic loop of Arabidopsis PIN1 auxin efflux carrier harbors hallmarks
  of an intrinsically disordered protein
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: 3E5EF7F0-F248-11E8-B48F-1D18A9856A87
volume: 23
year: '2022'
...
---
_id: '11542'
article_processing_charge: No
author:
- first_name: Rouven
  full_name: Schulz, Rouven
  id: 4C5E7B96-F248-11E8-B48F-1D18A9856A87
  last_name: Schulz
  orcid: 0000-0001-5297-733X
citation:
  ama: Schulz R. Source Data (Chimeric GPCRs mimic distinct signaling pathways and
    modulate microglia responses). 2022. doi:<a href="https://doi.org/10.15479/AT:ISTA:11542">10.15479/AT:ISTA:11542</a>
  apa: Schulz, R. (2022). Source Data (Chimeric GPCRs mimic distinct signaling pathways
    and modulate microglia responses). Institute of Science and Technology Austria.
    <a href="https://doi.org/10.15479/AT:ISTA:11542">https://doi.org/10.15479/AT:ISTA:11542</a>
  chicago: Schulz, Rouven. “Source Data (Chimeric GPCRs Mimic Distinct Signaling Pathways
    and Modulate Microglia Responses).” Institute of Science and Technology Austria,
    2022. <a href="https://doi.org/10.15479/AT:ISTA:11542">https://doi.org/10.15479/AT:ISTA:11542</a>.
  ieee: R. Schulz, “Source Data (Chimeric GPCRs mimic distinct signaling pathways
    and modulate microglia responses).” Institute of Science and Technology Austria,
    2022.
  ista: Schulz R. 2022. Source Data (Chimeric GPCRs mimic distinct signaling pathways
    and modulate microglia responses), Institute of Science and Technology Austria,
    <a href="https://doi.org/10.15479/AT:ISTA:11542">10.15479/AT:ISTA:11542</a>.
  mla: Schulz, Rouven. <i>Source Data (Chimeric GPCRs Mimic Distinct Signaling Pathways
    and Modulate Microglia Responses)</i>. Institute of Science and Technology Austria,
    2022, doi:<a href="https://doi.org/10.15479/AT:ISTA:11542">10.15479/AT:ISTA:11542</a>.
  short: R. Schulz, (2022).
contributor:
- contributor_type: contact_person
  first_name: Sandra
  id: 36ACD32E-F248-11E8-B48F-1D18A9856A87
  last_name: Siegert
  orcid: 0000-0001-8635-0877
date_created: 2022-07-08T11:03:02Z
date_published: 2022-01-01T00:00:00Z
date_updated: 2024-02-21T12:34:51Z
department:
- _id: GradSch
- _id: SaSi
doi: 10.15479/AT:ISTA:11542
file:
- access_level: open_access
  checksum: 71e8186583f3adbb6c69a88ac9e6e49b
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  creator: rschulz
  date_created: 2022-07-08T10:56:52Z
  date_updated: 2022-07-08T10:56:52Z
  file_id: '11543'
  file_name: Source Data.xlsx
  file_size: 135784571
  relation: main_file
  success: 1
file_date_updated: 2022-07-08T10:56:52Z
has_accepted_license: '1'
oa: 1
oa_version: None
publisher: Institute of Science and Technology Austria
related_material:
  link:
  - relation: contains
    url: https://www.biorxiv.org/content/10.1101/2021.06.21.449162v1
  record:
  - id: '11995'
    relation: used_in_publication
    status: public
status: public
title: Source Data (Chimeric GPCRs mimic distinct signaling pathways and modulate
  microglia responses)
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: research_data
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '2022'
...
---
_id: '11545'
abstract:
- lang: eng
  text: "We classify contravariant pairings between standard Whittaker modules and
    Verma modules over a complex semisimple Lie algebra. These contravariant pairings
    are useful in extending several classical techniques for category O to the Miličić–Soergel
    category N . We introduce a class of costandard modules which generalize dual
    Verma modules, and describe canonical maps from standard to costandard modules
    in terms of contravariant pairings.\r\nWe show that costandard modules have unique
    irreducible submodules and share the same composition factors as the corresponding
    standard Whittaker modules. We show that costandard modules give an algebraic
    characterization of the global sections of costandard twisted Harish-Chandra sheaves
    on the associated flag variety, which are defined using holonomic duality of D-modules.
    We prove that with these costandard modules, blocks of category\r\nN have the
    structure of highest weight categories and we establish a BGG reciprocity theorem
    for N ."
acknowledgement: We thank Catharina Stroppel and Jens Niklas Eberhardt for interesting
  discussions. The first author acknowledges the support of the European Union's Horizon
  2020 research and innovation programme under the Marie Skłodowska-Curie Grant Agreement
  No. 754411. The second author is supported by the National Science Foundation Award
  No. 1803059 and the Australian Research Council grant DP170101579.
article_processing_charge: Yes (via OA deal)
article_type: original
author:
- first_name: Adam
  full_name: Brown, Adam
  id: 70B7FDF6-608D-11E9-9333-8535E6697425
  last_name: Brown
- first_name: Anna
  full_name: Romanov, Anna
  last_name: Romanov
citation:
  ama: Brown A, Romanov A. Contravariant pairings between standard Whittaker modules
    and Verma modules. <i>Journal of Algebra</i>. 2022;609(11):145-179. doi:<a href="https://doi.org/10.1016/j.jalgebra.2022.06.017">10.1016/j.jalgebra.2022.06.017</a>
  apa: Brown, A., &#38; Romanov, A. (2022). Contravariant pairings between standard
    Whittaker modules and Verma modules. <i>Journal of Algebra</i>. Elsevier. <a href="https://doi.org/10.1016/j.jalgebra.2022.06.017">https://doi.org/10.1016/j.jalgebra.2022.06.017</a>
  chicago: Brown, Adam, and Anna Romanov. “Contravariant Pairings between Standard
    Whittaker Modules and Verma Modules.” <i>Journal of Algebra</i>. Elsevier, 2022.
    <a href="https://doi.org/10.1016/j.jalgebra.2022.06.017">https://doi.org/10.1016/j.jalgebra.2022.06.017</a>.
  ieee: A. Brown and A. Romanov, “Contravariant pairings between standard Whittaker
    modules and Verma modules,” <i>Journal of Algebra</i>, vol. 609, no. 11. Elsevier,
    pp. 145–179, 2022.
  ista: Brown A, Romanov A. 2022. Contravariant pairings between standard Whittaker
    modules and Verma modules. Journal of Algebra. 609(11), 145–179.
  mla: Brown, Adam, and Anna Romanov. “Contravariant Pairings between Standard Whittaker
    Modules and Verma Modules.” <i>Journal of Algebra</i>, vol. 609, no. 11, Elsevier,
    2022, pp. 145–79, doi:<a href="https://doi.org/10.1016/j.jalgebra.2022.06.017">10.1016/j.jalgebra.2022.06.017</a>.
  short: A. Brown, A. Romanov, Journal of Algebra 609 (2022) 145–179.
date_created: 2022-07-08T11:40:07Z
date_published: 2022-11-01T00:00:00Z
date_updated: 2023-08-03T11:56:30Z
day: '01'
ddc:
- '510'
department:
- _id: HeEd
doi: 10.1016/j.jalgebra.2022.06.017
ec_funded: 1
external_id:
  isi:
  - '000861841100004'
file:
- access_level: open_access
  checksum: 82abaee3d7837f703e499a9ecbb25b7c
  content_type: application/pdf
  creator: dernst
  date_created: 2023-02-02T07:32:48Z
  date_updated: 2023-02-02T07:32:48Z
  file_id: '12473'
  file_name: 2022_JournalAlgebra_Brown.pdf
  file_size: 582962
  relation: main_file
  success: 1
file_date_updated: 2023-02-02T07:32:48Z
has_accepted_license: '1'
intvolume: '       609'
isi: 1
issue: '11'
keyword:
- Algebra and Number Theory
language:
- iso: eng
month: '11'
oa: 1
oa_version: Published Version
page: 145-179
project:
- _id: 260C2330-B435-11E9-9278-68D0E5697425
  call_identifier: H2020
  grant_number: '754411'
  name: ISTplus - Postdoctoral Fellowships
publication: Journal of Algebra
publication_identifier:
  issn:
  - 0021-8693
publication_status: published
publisher: Elsevier
quality_controlled: '1'
scopus_import: '1'
status: public
title: Contravariant pairings between standard Whittaker modules and Verma modules
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 609
year: '2022'
...
---
_id: '11546'
abstract:
- lang: eng
  text: Local adaptation leads to differences between populations within a species.
    In many systems, similar environmental contrasts occur repeatedly, sometimes driving
    parallel phenotypic evolution. Understanding the genomic basis of local adaptation
    and parallel evolution is a major goal of evolutionary genomics. It is now known
    that by preventing the break-up of favourable combinations of alleles across multiple
    loci, genetic architectures that reduce recombination, like chromosomal inversions,
    can make an important contribution to local adaptation. However, little is known
    about whether inversions also contribute disproportionately to parallel evolution.
    Our aim here is to highlight this knowledge gap, to showcase existing studies,
    and to illustrate the differences between genomic architectures with and without
    inversions using simple models. We predict that by generating stronger effective
    selection, inversions can sometimes speed up the parallel adaptive process or
    enable parallel adaptation where it would be impossible otherwise, but this is
    highly dependent on the spatial setting. We highlight that further empirical work
    is needed, in particular to cover a broader taxonomic range and to understand
    the relative importance of inversions compared to genomic regions without inversions.
acknowledgement: We thank the editor and two anonymous reviewers for their helpful
  and interesting comments on this manuscript.
article_number: '20210203'
article_processing_charge: Yes (via OA deal)
article_type: original
author:
- first_name: Anja M
  full_name: Westram, Anja M
  id: 3C147470-F248-11E8-B48F-1D18A9856A87
  last_name: Westram
  orcid: 0000-0003-1050-4969
- first_name: Rui
  full_name: Faria, Rui
  last_name: Faria
- first_name: Kerstin
  full_name: Johannesson, Kerstin
  last_name: Johannesson
- first_name: Roger
  full_name: Butlin, Roger
  last_name: Butlin
- first_name: Nicholas H
  full_name: Barton, Nicholas H
  id: 4880FE40-F248-11E8-B48F-1D18A9856A87
  last_name: Barton
  orcid: 0000-0002-8548-5240
citation:
  ama: 'Westram AM, Faria R, Johannesson K, Butlin R, Barton NH. Inversions and parallel
    evolution. <i>Philosophical Transactions of the Royal Society B: Biological Sciences</i>.
    2022;377(1856). doi:<a href="https://doi.org/10.1098/rstb.2021.0203">10.1098/rstb.2021.0203</a>'
  apa: 'Westram, A. M., Faria, R., Johannesson, K., Butlin, R., &#38; Barton, N. H.
    (2022). Inversions and parallel evolution. <i>Philosophical Transactions of the
    Royal Society B: Biological Sciences</i>. Royal Society of London. <a href="https://doi.org/10.1098/rstb.2021.0203">https://doi.org/10.1098/rstb.2021.0203</a>'
  chicago: 'Westram, Anja M, Rui Faria, Kerstin Johannesson, Roger Butlin, and Nicholas
    H Barton. “Inversions and Parallel Evolution.” <i>Philosophical Transactions of
    the Royal Society B: Biological Sciences</i>. Royal Society of London, 2022. <a
    href="https://doi.org/10.1098/rstb.2021.0203">https://doi.org/10.1098/rstb.2021.0203</a>.'
  ieee: 'A. M. Westram, R. Faria, K. Johannesson, R. Butlin, and N. H. Barton, “Inversions
    and parallel evolution,” <i>Philosophical Transactions of the Royal Society B:
    Biological Sciences</i>, vol. 377, no. 1856. Royal Society of London, 2022.'
  ista: 'Westram AM, Faria R, Johannesson K, Butlin R, Barton NH. 2022. Inversions
    and parallel evolution. Philosophical Transactions of the Royal Society B: Biological
    Sciences. 377(1856), 20210203.'
  mla: 'Westram, Anja M., et al. “Inversions and Parallel Evolution.” <i>Philosophical
    Transactions of the Royal Society B: Biological Sciences</i>, vol. 377, no. 1856,
    20210203, Royal Society of London, 2022, doi:<a href="https://doi.org/10.1098/rstb.2021.0203">10.1098/rstb.2021.0203</a>.'
  short: 'A.M. Westram, R. Faria, K. Johannesson, R. Butlin, N.H. Barton, Philosophical
    Transactions of the Royal Society B: Biological Sciences 377 (2022).'
date_created: 2022-07-08T11:41:56Z
date_published: 2022-08-01T00:00:00Z
date_updated: 2023-08-03T11:55:42Z
day: '01'
ddc:
- '570'
department:
- _id: BeVi
- _id: NiBa
doi: 10.1098/rstb.2021.0203
external_id:
  isi:
  - '000812317300005'
file:
- access_level: open_access
  checksum: 49f69428f3dcf5ce3ff281f7d199e9df
  content_type: application/pdf
  creator: dernst
  date_created: 2023-02-02T08:20:29Z
  date_updated: 2023-02-02T08:20:29Z
  file_id: '12479'
  file_name: 2022_PhilosophicalTransactionsB_Westram.pdf
  file_size: 920304
  relation: main_file
  success: 1
file_date_updated: 2023-02-02T08:20:29Z
has_accepted_license: '1'
intvolume: '       377'
isi: 1
issue: '1856'
keyword:
- General Agricultural and Biological Sciences
- General Biochemistry
- Genetics and Molecular Biology
language:
- iso: eng
month: '08'
oa: 1
oa_version: Published Version
project:
- _id: 05959E1C-7A3F-11EA-A408-12923DDC885E
  grant_number: P32166
  name: The maintenance of alternative adaptive peaks in snapdragons
publication: 'Philosophical Transactions of the Royal Society B: Biological Sciences'
publication_identifier:
  eissn:
  - 1471-2970
  issn:
  - 0962-8436
publication_status: published
publisher: Royal Society of London
quality_controlled: '1'
scopus_import: '1'
status: public
title: Inversions and parallel evolution
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 377
year: '2022'
...
---
_id: '11551'
abstract:
- lang: eng
  text: Imbalanced mitochondrial dNTP pools are known players in the pathogenesis
    of multiple human diseases. Here we show that, even under physiological conditions,
    dGTP is largely overrepresented among other dNTPs in mitochondria of mouse tissues
    and human cultured cells. In addition, a vast majority of mitochondrial dGTP is
    tightly bound to NDUFA10, an accessory subunit of complex I of the mitochondrial
    respiratory chain. NDUFA10 shares a deoxyribonucleoside kinase (dNK) domain with
    deoxyribonucleoside kinases in the nucleotide salvage pathway, though no specific
    function beyond stabilizing the complex I holoenzyme has been described for this
    subunit. We mutated the dNK domain of NDUFA10 in human HEK-293T cells while preserving
    complex I assembly and activity. The NDUFA10E160A/R161A shows reduced dGTP binding
    capacity in vitro and leads to a 50% reduction in mitochondrial dGTP content,
    proving that most dGTP is directly bound to the dNK domain of NDUFA10. This interaction
    may represent a hitherto unknown mechanism regulating mitochondrial dNTP availability
    and linking oxidative metabolism to DNA maintenance.
acknowledgement: "We thank Dr, Luke Formosa (Department of Biochemistry and Molecular
  Biology, Monash Biomedicine Discovery Institute, Monash University, Melbourne, Australia)
  for his valuable advice and assistance on NDUFA10 molecular studies and Dr. Francesc
  Canals and his team (Proteomics Laboratory, Vall d’Hebron Institute of Oncology
  [VHIO], Universitat Autònoma de Barcelona, Barcelona, Spain) for their assistance
  with LC-MS/MS analyses. This work was supported by the Spanish Ministry of Industry,
  Economy and Competitiveness [grants BFU2014-52618-R, SAF2017-87506, and PID2020-112929RB-I00
  to Y.C.], by the Spanish Instituto de Salud Carlos III [grants PI21/00554 and PMP15/00025
  to R.M.], co-financed by the European Regional Development Fund (ERDF), and by an
  NHMRC Project grant to M.R. (GNT1164459).\r\n"
article_number: '620'
article_processing_charge: No
author:
- first_name: David
  full_name: Molina-Granada, David
  last_name: Molina-Granada
- first_name: Emiliano
  full_name: González-Vioque, Emiliano
  last_name: González-Vioque
- first_name: Marris G.
  full_name: Dibley, Marris G.
  last_name: Dibley
- first_name: Raquel
  full_name: Cabrera-Pérez, Raquel
  last_name: Cabrera-Pérez
- first_name: Antoni
  full_name: Vallbona-Garcia, Antoni
  last_name: Vallbona-Garcia
- first_name: Javier
  full_name: Torres-Torronteras, Javier
  last_name: Torres-Torronteras
- first_name: Leonid A
  full_name: Sazanov, Leonid A
  id: 338D39FE-F248-11E8-B48F-1D18A9856A87
  last_name: Sazanov
  orcid: 0000-0002-0977-7989
- first_name: Michael T.
  full_name: Ryan, Michael T.
  last_name: Ryan
- first_name: Yolanda
  full_name: Cámara, Yolanda
  last_name: Cámara
- first_name: Ramon
  full_name: Martí, Ramon
  last_name: Martí
citation:
  ama: Molina-Granada D, González-Vioque E, Dibley MG, et al. Most mitochondrial dGTP
    is tightly bound to respiratory complex I through the NDUFA10 subunit. <i>Communications
    Biology</i>. 2022;5(1). doi:<a href="https://doi.org/10.1038/s42003-022-03568-6">10.1038/s42003-022-03568-6</a>
  apa: Molina-Granada, D., González-Vioque, E., Dibley, M. G., Cabrera-Pérez, R.,
    Vallbona-Garcia, A., Torres-Torronteras, J., … Martí, R. (2022). Most mitochondrial
    dGTP is tightly bound to respiratory complex I through the NDUFA10 subunit. <i>Communications
    Biology</i>. Springer Nature. <a href="https://doi.org/10.1038/s42003-022-03568-6">https://doi.org/10.1038/s42003-022-03568-6</a>
  chicago: Molina-Granada, David, Emiliano González-Vioque, Marris G. Dibley, Raquel
    Cabrera-Pérez, Antoni Vallbona-Garcia, Javier Torres-Torronteras, Leonid A Sazanov,
    Michael T. Ryan, Yolanda Cámara, and Ramon Martí. “Most Mitochondrial DGTP Is
    Tightly Bound to Respiratory Complex I through the NDUFA10 Subunit.” <i>Communications
    Biology</i>. Springer Nature, 2022. <a href="https://doi.org/10.1038/s42003-022-03568-6">https://doi.org/10.1038/s42003-022-03568-6</a>.
  ieee: D. Molina-Granada <i>et al.</i>, “Most mitochondrial dGTP is tightly bound
    to respiratory complex I through the NDUFA10 subunit,” <i>Communications Biology</i>,
    vol. 5, no. 1. Springer Nature, 2022.
  ista: Molina-Granada D, González-Vioque E, Dibley MG, Cabrera-Pérez R, Vallbona-Garcia
    A, Torres-Torronteras J, Sazanov LA, Ryan MT, Cámara Y, Martí R. 2022. Most mitochondrial
    dGTP is tightly bound to respiratory complex I through the NDUFA10 subunit. Communications
    Biology. 5(1), 620.
  mla: Molina-Granada, David, et al. “Most Mitochondrial DGTP Is Tightly Bound to
    Respiratory Complex I through the NDUFA10 Subunit.” <i>Communications Biology</i>,
    vol. 5, no. 1, 620, Springer Nature, 2022, doi:<a href="https://doi.org/10.1038/s42003-022-03568-6">10.1038/s42003-022-03568-6</a>.
  short: D. Molina-Granada, E. González-Vioque, M.G. Dibley, R. Cabrera-Pérez, A.
    Vallbona-Garcia, J. Torres-Torronteras, L.A. Sazanov, M.T. Ryan, Y. Cámara, R.
    Martí, Communications Biology 5 (2022).
date_created: 2022-07-10T22:01:52Z
date_published: 2022-06-23T00:00:00Z
date_updated: 2023-08-03T11:51:58Z
day: '23'
ddc:
- '570'
department:
- _id: LeSa
doi: 10.1038/s42003-022-03568-6
external_id:
  isi:
  - '000815098500002'
  pmid:
  - ' 35739187'
file:
- access_level: open_access
  checksum: 965f88bbcef3fd0c3e121340555c4467
  content_type: application/pdf
  creator: kschuh
  date_created: 2022-07-13T07:44:58Z
  date_updated: 2022-07-13T07:44:58Z
  file_id: '11571'
  file_name: 2022_communicationsbiology_Molina-Granada.pdf
  file_size: 2335369
  relation: main_file
  success: 1
file_date_updated: 2022-07-13T07:44:58Z
has_accepted_license: '1'
intvolume: '         5'
isi: 1
issue: '1'
language:
- iso: eng
month: '06'
oa: 1
oa_version: Published Version
pmid: 1
publication: Communications Biology
publication_identifier:
  eissn:
  - '23993642'
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
scopus_import: '1'
status: public
title: Most mitochondrial dGTP is tightly bound to respiratory complex I through the
  NDUFA10 subunit
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 5
year: '2022'
...
---
_id: '11552'
abstract:
- lang: eng
  text: Rotational dynamics of D2 molecules inside helium nanodroplets is induced
    by a moderately intense femtosecond pump pulse and measured as a function of time
    by recording the yield of HeD+ ions, created through strong-field dissociative
    ionization with a delayed femtosecond probe pulse. The yield oscillates with a
    period of 185 fs, reflecting field-free rotational wave packet dynamics, and the
    oscillation persists for more than 500 periods. Within the experimental uncertainty,
    the rotational constant BHe of the in-droplet D2 molecule, determined by Fourier
    analysis, is the same as Bgas for an isolated D2 molecule. Our observations show
    that the D2 molecules inside helium nanodroplets essentially rotate as free D2
    molecules.
article_number: '243201'
article_processing_charge: No
arxiv: 1
author:
- first_name: Junjie
  full_name: Qiang, Junjie
  last_name: Qiang
- first_name: Lianrong
  full_name: Zhou, Lianrong
  last_name: Zhou
- first_name: Peifen
  full_name: Lu, Peifen
  last_name: Lu
- first_name: Kang
  full_name: Lin, Kang
  last_name: Lin
- first_name: Yongzhe
  full_name: Ma, Yongzhe
  last_name: Ma
- first_name: Shengzhe
  full_name: Pan, Shengzhe
  last_name: Pan
- first_name: Chenxu
  full_name: Lu, Chenxu
  last_name: Lu
- first_name: Wenyu
  full_name: Jiang, Wenyu
  last_name: Jiang
- first_name: Fenghao
  full_name: Sun, Fenghao
  last_name: Sun
- first_name: Wenbin
  full_name: Zhang, Wenbin
  last_name: Zhang
- first_name: Hui
  full_name: Li, Hui
  last_name: Li
- first_name: Xiaochun
  full_name: Gong, Xiaochun
  last_name: Gong
- first_name: Ilya Sh
  full_name: Averbukh, Ilya Sh
  last_name: Averbukh
- first_name: Yehiam
  full_name: Prior, Yehiam
  last_name: Prior
- first_name: Constant A.
  full_name: Schouder, Constant A.
  last_name: Schouder
- first_name: Henrik
  full_name: Stapelfeldt, Henrik
  last_name: Stapelfeldt
- first_name: Igor
  full_name: Cherepanov, Igor
  id: 339C7E5A-F248-11E8-B48F-1D18A9856A87
  last_name: Cherepanov
- first_name: Mikhail
  full_name: Lemeshko, Mikhail
  id: 37CB05FA-F248-11E8-B48F-1D18A9856A87
  last_name: Lemeshko
  orcid: 0000-0002-6990-7802
- first_name: Wolfgang
  full_name: Jäger, Wolfgang
  last_name: Jäger
- first_name: Jian
  full_name: Wu, Jian
  last_name: Wu
citation:
  ama: Qiang J, Zhou L, Lu P, et al. Femtosecond rotational dynamics of D2 molecules
    in superfluid helium nanodroplets. <i>Physical Review Letters</i>. 2022;128(24).
    doi:<a href="https://doi.org/10.1103/PhysRevLett.128.243201">10.1103/PhysRevLett.128.243201</a>
  apa: Qiang, J., Zhou, L., Lu, P., Lin, K., Ma, Y., Pan, S., … Wu, J. (2022). Femtosecond
    rotational dynamics of D2 molecules in superfluid helium nanodroplets. <i>Physical
    Review Letters</i>. American Physical Society. <a href="https://doi.org/10.1103/PhysRevLett.128.243201">https://doi.org/10.1103/PhysRevLett.128.243201</a>
  chicago: Qiang, Junjie, Lianrong Zhou, Peifen Lu, Kang Lin, Yongzhe Ma, Shengzhe
    Pan, Chenxu Lu, et al. “Femtosecond Rotational Dynamics of D2 Molecules in Superfluid
    Helium Nanodroplets.” <i>Physical Review Letters</i>. American Physical Society,
    2022. <a href="https://doi.org/10.1103/PhysRevLett.128.243201">https://doi.org/10.1103/PhysRevLett.128.243201</a>.
  ieee: J. Qiang <i>et al.</i>, “Femtosecond rotational dynamics of D2 molecules in
    superfluid helium nanodroplets,” <i>Physical Review Letters</i>, vol. 128, no.
    24. American Physical Society, 2022.
  ista: Qiang J, Zhou L, Lu P, Lin K, Ma Y, Pan S, Lu C, Jiang W, Sun F, Zhang W,
    Li H, Gong X, Averbukh IS, Prior Y, Schouder CA, Stapelfeldt H, Cherepanov I,
    Lemeshko M, Jäger W, Wu J. 2022. Femtosecond rotational dynamics of D2 molecules
    in superfluid helium nanodroplets. Physical Review Letters. 128(24), 243201.
  mla: Qiang, Junjie, et al. “Femtosecond Rotational Dynamics of D2 Molecules in Superfluid
    Helium Nanodroplets.” <i>Physical Review Letters</i>, vol. 128, no. 24, 243201,
    American Physical Society, 2022, doi:<a href="https://doi.org/10.1103/PhysRevLett.128.243201">10.1103/PhysRevLett.128.243201</a>.
  short: J. Qiang, L. Zhou, P. Lu, K. Lin, Y. Ma, S. Pan, C. Lu, W. Jiang, F. Sun,
    W. Zhang, H. Li, X. Gong, I.S. Averbukh, Y. Prior, C.A. Schouder, H. Stapelfeldt,
    I. Cherepanov, M. Lemeshko, W. Jäger, J. Wu, Physical Review Letters 128 (2022).
date_created: 2022-07-10T22:01:52Z
date_published: 2022-06-16T00:00:00Z
date_updated: 2023-08-03T11:54:14Z
day: '16'
department:
- _id: MiLe
doi: 10.1103/PhysRevLett.128.243201
ec_funded: 1
external_id:
  arxiv:
  - '2201.09281'
  isi:
  - '000820659700002'
intvolume: '       128'
isi: 1
issue: '24'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://doi.org/10.48550/arXiv.2201.09281
month: '06'
oa: 1
oa_version: Submitted Version
project:
- _id: 2688CF98-B435-11E9-9278-68D0E5697425
  call_identifier: H2020
  grant_number: '801770'
  name: 'Angulon: physics and applications of a new quasiparticle'
- _id: 2564DBCA-B435-11E9-9278-68D0E5697425
  call_identifier: H2020
  grant_number: '665385'
  name: International IST Doctoral Program
publication: Physical Review Letters
publication_identifier:
  eissn:
  - '10797114'
  issn:
  - '00319007'
publication_status: published
publisher: American Physical Society
quality_controlled: '1'
scopus_import: '1'
status: public
title: Femtosecond rotational dynamics of D2 molecules in superfluid helium nanodroplets
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 128
year: '2022'
...
---
_id: '11553'
abstract:
- lang: eng
  text: "In holomorphic dynamics, complex box mappings arise as first return maps
    to wellchosen domains. They are a generalization of polynomial-like mapping, where
    the domain of the return map can have infinitely many components. They turned
    out to be extremely useful in tackling diverse problems. The purpose of this paper
    is:\r\n• To illustrate some pathologies that can occur when a complex box mapping
    is not induced by a globally defined map and when its domain has infinitely many
    components, and to give conditions to avoid these issues.\r\n• To show that once
    one has a box mapping for a rational map, these conditions can be assumed to hold
    in a very natural setting. Thus, we call such complex box mappings dynamically
    natural. Having such box mappings is the first step in tackling many problems
    in one-dimensional dynamics.\r\n• Many results in holomorphic dynamics rely on
    an interplay between combinatorial and analytic techniques. In this setting, some
    of these tools are:\r\n  • the Enhanced Nest (a nest of puzzle pieces around critical
    points) from Kozlovski, Shen, van Strien (AnnMath 165:749–841, 2007), referred
    to below as KSS;\r\n  • the Covering Lemma (which controls the moduli of pullbacks
    of annuli) from Kahn and Lyubich (Ann Math 169(2):561–593, 2009);\r\n   • the
    QC-Criterion and the Spreading Principle from KSS.\r\nThe purpose of this paper
    is to make these tools more accessible so that they can be used as a ‘black box’,
    so one does not have to redo the proofs in new settings.\r\n• To give an intuitive,
    but also rather detailed, outline of the proof from KSS and Kozlovski and van
    Strien (Proc Lond Math Soc (3) 99:275–296, 2009) of the following results for
    non-renormalizable dynamically natural complex box mappings:\r\n   • puzzle pieces
    shrink to points,\r\n   • (under some assumptions) topologically conjugate non-renormalizable
    polynomials and box mappings are quasiconformally conjugate.\r\n• We prove the
    fundamental ergodic properties for dynamically natural box mappings. This leads
    to some necessary conditions for when such a box mapping supports a measurable
    invariant line field on its filled Julia set. These mappings\r\nare the analogues
    of Lattès maps in this setting.\r\n• We prove a version of Mañé’s Theorem for
    complex box mappings concerning expansion along orbits of points that avoid a
    neighborhood of the set of critical points."
acknowledgement: We would also like to thank Dzmitry Dudko and Dierk Schleicher for
  many stimulating discussions and encouragement during our work on this project,
  and Weixiao Shen, Mikhail Hlushchanka and the referee for helpful comments. We are
  grateful to Leon Staresinic who carefully read the revised version of the manuscript
  and provided many helpful suggestions.
article_processing_charge: No
article_type: original
author:
- first_name: Trevor
  full_name: Clark, Trevor
  last_name: Clark
- first_name: Kostiantyn
  full_name: Drach, Kostiantyn
  id: fe8209e2-906f-11eb-847d-950f8fc09115
  last_name: Drach
  orcid: 0000-0002-9156-8616
- first_name: Oleg
  full_name: Kozlovski, Oleg
  last_name: Kozlovski
- first_name: Sebastian Van
  full_name: Strien, Sebastian Van
  last_name: Strien
citation:
  ama: Clark T, Drach K, Kozlovski O, Strien SV. The dynamics of complex box mappings.
    <i>Arnold Mathematical Journal</i>. 2022;8(2):319-410. doi:<a href="https://doi.org/10.1007/s40598-022-00200-7">10.1007/s40598-022-00200-7</a>
  apa: Clark, T., Drach, K., Kozlovski, O., &#38; Strien, S. V. (2022). The dynamics
    of complex box mappings. <i>Arnold Mathematical Journal</i>. Springer Nature.
    <a href="https://doi.org/10.1007/s40598-022-00200-7">https://doi.org/10.1007/s40598-022-00200-7</a>
  chicago: Clark, Trevor, Kostiantyn Drach, Oleg Kozlovski, and Sebastian Van Strien.
    “The Dynamics of Complex Box Mappings.” <i>Arnold Mathematical Journal</i>. Springer
    Nature, 2022. <a href="https://doi.org/10.1007/s40598-022-00200-7">https://doi.org/10.1007/s40598-022-00200-7</a>.
  ieee: T. Clark, K. Drach, O. Kozlovski, and S. V. Strien, “The dynamics of complex
    box mappings,” <i>Arnold Mathematical Journal</i>, vol. 8, no. 2. Springer Nature,
    pp. 319–410, 2022.
  ista: Clark T, Drach K, Kozlovski O, Strien SV. 2022. The dynamics of complex box
    mappings. Arnold Mathematical Journal. 8(2), 319–410.
  mla: Clark, Trevor, et al. “The Dynamics of Complex Box Mappings.” <i>Arnold Mathematical
    Journal</i>, vol. 8, no. 2, Springer Nature, 2022, pp. 319–410, doi:<a href="https://doi.org/10.1007/s40598-022-00200-7">10.1007/s40598-022-00200-7</a>.
  short: T. Clark, K. Drach, O. Kozlovski, S.V. Strien, Arnold Mathematical Journal
    8 (2022) 319–410.
date_created: 2022-07-10T22:01:53Z
date_published: 2022-06-01T00:00:00Z
date_updated: 2023-02-16T10:02:12Z
day: '01'
ddc:
- '500'
department:
- _id: VaKa
doi: 10.1007/s40598-022-00200-7
ec_funded: 1
file:
- access_level: open_access
  checksum: 16e7c659dee9073c6c8aeb87316ef201
  content_type: application/pdf
  creator: kschuh
  date_created: 2022-07-12T10:04:55Z
  date_updated: 2022-07-12T10:04:55Z
  file_id: '11559'
  file_name: 2022_ArnoldMathematicalJournal_Clark.pdf
  file_size: 2509915
  relation: main_file
  success: 1
file_date_updated: 2022-07-12T10:04:55Z
has_accepted_license: '1'
intvolume: '         8'
issue: '2'
language:
- iso: eng
month: '06'
oa: 1
oa_version: None
page: 319-410
project:
- _id: 9B8B92DE-BA93-11EA-9121-9846C619BF3A
  call_identifier: H2020
  grant_number: '885707'
  name: Spectral rigidity and integrability for billiards and geodesic flows
publication: Arnold Mathematical Journal
publication_identifier:
  eissn:
  - 2199-6806
  issn:
  - 2199-6792
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
related_material:
  link:
  - relation: erratum
    url: https://doi.org/10.1007/s40598-022-00209-y
  - relation: erratum
    url: https://doi.org/10.1007/s40598-022-00218-x
scopus_import: '1'
status: public
title: The dynamics of complex box mappings
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 8
year: '2022'
...
---
_id: '11556'
abstract:
- lang: eng
  text: "We revisit two basic Direct Simulation Monte Carlo Methods to model aggregation
    kinetics and extend them for aggregation processes with collisional fragmentation
    (shattering). We test the performance and accuracy of the extended methods and
    compare their performance with efficient deterministic finite-difference method
    applied to the same model. We validate the stochastic methods on the test problems
    and apply them to verify the existence of oscillating regimes in the aggregation-fragmentation
    kinetics recently detected in deterministic simulations. We confirm the emergence
    of steady oscillations of densities in such systems and prove the stability of
    the\r\noscillations with respect to fluctuations and noise."
acknowledgement: Zhores supercomputer of Skolkovo Institute of Science and Technology
  [68] has been used in the present research. S.A.M. was supported by Moscow Center
  for Fundamental and Applied Mathematics (the agreement with the Ministry of Education
  and Science of the Russian Federation No. 075-15-2019-1624). A.I.O. acknowledges
  RFBR project No. 20-31-90022. N.V.B. acknowledges the support of the Analytical
  Center (subsidy agreement 000000D730321P5Q0002, Grant No. 70-2021-00145 02.11.2021).
article_number: '111439'
article_processing_charge: No
article_type: original
arxiv: 1
author:
- first_name: Aleksei
  full_name: Kalinov, Aleksei
  id: 44b7120e-eb97-11eb-a6c2-e1557aa81d02
  last_name: Kalinov
  orcid: 0000-0003-2189-3904
- first_name: A.I.
  full_name: Osinskiy, A.I.
  last_name: Osinskiy
- first_name: S.A.
  full_name: Matveev, S.A.
  last_name: Matveev
- first_name: W.
  full_name: Otieno, W.
  last_name: Otieno
- first_name: N.V.
  full_name: Brilliantov, N.V.
  last_name: Brilliantov
citation:
  ama: Kalinov A, Osinskiy AI, Matveev SA, Otieno W, Brilliantov NV. Direct simulation
    Monte Carlo for new regimes in aggregation-fragmentation kinetics. <i>Journal
    of Computational Physics</i>. 2022;467. doi:<a href="https://doi.org/10.1016/j.jcp.2022.111439">10.1016/j.jcp.2022.111439</a>
  apa: Kalinov, A., Osinskiy, A. I., Matveev, S. A., Otieno, W., &#38; Brilliantov,
    N. V. (2022). Direct simulation Monte Carlo for new regimes in aggregation-fragmentation
    kinetics. <i>Journal of Computational Physics</i>. Elsevier. <a href="https://doi.org/10.1016/j.jcp.2022.111439">https://doi.org/10.1016/j.jcp.2022.111439</a>
  chicago: Kalinov, Aleksei, A.I. Osinskiy, S.A. Matveev, W. Otieno, and N.V. Brilliantov.
    “Direct Simulation Monte Carlo for New Regimes in Aggregation-Fragmentation Kinetics.”
    <i>Journal of Computational Physics</i>. Elsevier, 2022. <a href="https://doi.org/10.1016/j.jcp.2022.111439">https://doi.org/10.1016/j.jcp.2022.111439</a>.
  ieee: A. Kalinov, A. I. Osinskiy, S. A. Matveev, W. Otieno, and N. V. Brilliantov,
    “Direct simulation Monte Carlo for new regimes in aggregation-fragmentation kinetics,”
    <i>Journal of Computational Physics</i>, vol. 467. Elsevier, 2022.
  ista: Kalinov A, Osinskiy AI, Matveev SA, Otieno W, Brilliantov NV. 2022. Direct
    simulation Monte Carlo for new regimes in aggregation-fragmentation kinetics.
    Journal of Computational Physics. 467, 111439.
  mla: Kalinov, Aleksei, et al. “Direct Simulation Monte Carlo for New Regimes in
    Aggregation-Fragmentation Kinetics.” <i>Journal of Computational Physics</i>,
    vol. 467, 111439, Elsevier, 2022, doi:<a href="https://doi.org/10.1016/j.jcp.2022.111439">10.1016/j.jcp.2022.111439</a>.
  short: A. Kalinov, A.I. Osinskiy, S.A. Matveev, W. Otieno, N.V. Brilliantov, Journal
    of Computational Physics 467 (2022).
date_created: 2022-07-11T12:19:59Z
date_published: 2022-10-15T00:00:00Z
date_updated: 2023-08-03T11:55:06Z
day: '15'
ddc:
- '518'
department:
- _id: GradSch
- _id: ChWo
doi: 10.1016/j.jcp.2022.111439
external_id:
  arxiv:
  - '2103.09481'
  isi:
  - '000917225500013'
intvolume: '       467'
isi: 1
keyword:
- Computer Science Applications
- Physics and Astronomy (miscellaneous)
- Applied Mathematics
- Computational Mathematics
- Modeling and Simulation
- Numerical Analysis
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://doi.org/10.48550/arXiv.2103.09481
month: '10'
oa: 1
oa_version: Preprint
publication: Journal of Computational Physics
publication_identifier:
  issn:
  - 0021-9991
publication_status: published
publisher: Elsevier
quality_controlled: '1'
status: public
title: Direct simulation Monte Carlo for new regimes in aggregation-fragmentation
  kinetics
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 467
year: '2022'
...
---
_id: '11587'
abstract:
- lang: eng
  text: "Background: Accurate and comprehensive annotation of transcript sequences
    is essential for transcript quantification and differential gene and transcript
    expression analysis. Single-molecule long-read sequencing technologies provide
    improved integrity of transcript structures including alternative splicing, and
    transcription start and polyadenylation sites. However, accuracy is significantly
    affected by sequencing errors, mRNA degradation, or incomplete cDNA synthesis.\r\nResults:
    We present a new and comprehensive Arabidopsis thaliana Reference Transcript Dataset
    3 (AtRTD3). AtRTD3 contains over 169,000 transcripts—twice that of the best current
    Arabidopsis transcriptome and including over 1500 novel genes. Seventy-eight percent
    of transcripts are from Iso-seq with accurately defined splice junctions and transcription
    start and end sites. We develop novel methods to determine splice junctions and
    transcription start and end sites accurately. Mismatch profiles around splice
    junctions provide a powerful feature to distinguish correct splice junctions and
    remove false splice junctions. Stratified approaches identify high-confidence
    transcription start and end sites and remove fragmentary transcripts due to degradation.
    AtRTD3 is a major improvement over existing transcriptomes as demonstrated by
    analysis of an Arabidopsis cold response RNA-seq time-series. AtRTD3 provides
    higher resolution of transcript expression profiling and identifies cold-induced
    differential transcription start and polyadenylation site usage.\r\nConclusions:
    AtRTD3 is the most comprehensive Arabidopsis transcriptome currently. It improves
    the precision of differential gene and transcript expression, differential alternative
    splicing, and transcription start/end site usage analysis from RNA-seq data. The
    novel methods for identifying accurate splice junctions and transcription start/end
    sites are widely applicable and will improve single-molecule sequencing analysis
    from any species."
acknowledgement: "This work was jointly supported by funding from the Biotechnology
  and Biological Sciences Research Council (BBSRC) BB/P009751/1 to JB; BB/R014582/1
  to RW and RZ; BB/S020160/1 to RZ; BB/S004610/1 (16 ERA-CAPS BARN) to RW; the Scottish
  Government Rural and Environment Science and Analytical Services division (RESAS)
  [to RZ, RW, and JB]; the\r\nNational Science Foundation (MCB-2014408) and the National
  Institute of Health (NIH) (GM-114297) to E.H.; S. H. was supported by funding to
  K.D. from the University of York; the Austrian Science Fund (FWF) SFB F43 to AB
  and MJ and [P26333] to MK; The French Agence Nationale de la Recherche grant ANR-16-CE12-0032
  to MC; the Japan Science and\r\nTechnology Agency (JST), the Core Research for Evolutionary
  Science and Technology (CREST; Grant Number JPMJCR13B4) to M.S.; the National Science
  Foundation (Grant No. DBI1949036 to A.b.H and A.S.N.R, and Grant No. MCB 2014542
  to E.H. and A.S.N.R.); and the DOE Office of Science, Office of Biological and Environmental
  Research (Grant\r\nNo. DE-SC0010733) to A.S.N.R and A.b.H.; the Deutsche Forschungsgemeinschaft
  (DFG) STA653/14-1 and STA653/15-1 to DS; the National Science Foundation grant (IOS-154173)
  to Q.Q.L.; the German Research Foundation (DFG) WA2167/8-1 to AW and SFB1101/C03
  to AW and TWK; the Research Grants Council (RGC) of Hong Kong (GRF 12103020) to
  LX. NSF grant IOS-1849708 and NSF EPSCoR grant 1826836 to RS; the Academia Sinica
  to S.-L. T."
article_number: '149'
article_processing_charge: No
article_type: original
author:
- first_name: Runxuan
  full_name: Zhang, Runxuan
  last_name: Zhang
- first_name: Richard
  full_name: Kuo, Richard
  last_name: Kuo
- first_name: Max
  full_name: Coulter, Max
  last_name: Coulter
- first_name: Cristiane P.G.
  full_name: Calixto, Cristiane P.G.
  last_name: Calixto
- first_name: Juan Carlos
  full_name: Entizne, Juan Carlos
  last_name: Entizne
- first_name: Wenbin
  full_name: Guo, Wenbin
  last_name: Guo
- first_name: Yamile
  full_name: Marquez, Yamile
  last_name: Marquez
- first_name: Linda
  full_name: Milne, Linda
  last_name: Milne
- first_name: Stefan
  full_name: Riegler, Stefan
  id: FF6018E0-D806-11E9-8E43-0B14E6697425
  last_name: Riegler
  orcid: 0000-0003-3413-1343
- first_name: Akihiro
  full_name: Matsui, Akihiro
  last_name: Matsui
- first_name: Maho
  full_name: Tanaka, Maho
  last_name: Tanaka
- first_name: Sarah
  full_name: Harvey, Sarah
  last_name: Harvey
- first_name: Yubang
  full_name: Gao, Yubang
  last_name: Gao
- first_name: Theresa
  full_name: Wießner-Kroh, Theresa
  last_name: Wießner-Kroh
- first_name: Alejandro
  full_name: Paniagua, Alejandro
  last_name: Paniagua
- first_name: Martin
  full_name: Crespi, Martin
  last_name: Crespi
- first_name: Katherine
  full_name: Denby, Katherine
  last_name: Denby
- first_name: Asa Ben
  full_name: Hur, Asa Ben
  last_name: Hur
- first_name: Enamul
  full_name: Huq, Enamul
  last_name: Huq
- first_name: Michael
  full_name: Jantsch, Michael
  last_name: Jantsch
- first_name: Artur
  full_name: Jarmolowski, Artur
  last_name: Jarmolowski
- first_name: Tino
  full_name: Koester, Tino
  last_name: Koester
- first_name: Sascha
  full_name: Laubinger, Sascha
  last_name: Laubinger
- first_name: Qingshun Quinn
  full_name: Li, Qingshun Quinn
  last_name: Li
- first_name: Lianfeng
  full_name: Gu, Lianfeng
  last_name: Gu
- first_name: Motoaki
  full_name: Seki, Motoaki
  last_name: Seki
- first_name: Dorothee
  full_name: Staiger, Dorothee
  last_name: Staiger
- first_name: Ramanjulu
  full_name: Sunkar, Ramanjulu
  last_name: Sunkar
- first_name: Zofia
  full_name: Szweykowska-Kulinska, Zofia
  last_name: Szweykowska-Kulinska
- first_name: Shih Long
  full_name: Tu, Shih Long
  last_name: Tu
- first_name: Andreas
  full_name: Wachter, Andreas
  last_name: Wachter
- first_name: Robbie
  full_name: Waugh, Robbie
  last_name: Waugh
- first_name: Liming
  full_name: Xiong, Liming
  last_name: Xiong
- first_name: Xiao Ning
  full_name: Zhang, Xiao Ning
  last_name: Zhang
- first_name: Ana
  full_name: Conesa, Ana
  last_name: Conesa
- first_name: Anireddy S.N.
  full_name: Reddy, Anireddy S.N.
  last_name: Reddy
- first_name: Andrea
  full_name: Barta, Andrea
  last_name: Barta
- first_name: Maria
  full_name: Kalyna, Maria
  last_name: Kalyna
- first_name: John W.S.
  full_name: Brown, John W.S.
  last_name: Brown
citation:
  ama: Zhang R, Kuo R, Coulter M, et al. A high-resolution single-molecule sequencing-based
    Arabidopsis transcriptome using novel methods of Iso-seq analysis. <i>Genome Biology</i>.
    2022;23. doi:<a href="https://doi.org/10.1186/s13059-022-02711-0">10.1186/s13059-022-02711-0</a>
  apa: Zhang, R., Kuo, R., Coulter, M., Calixto, C. P. G., Entizne, J. C., Guo, W.,
    … Brown, J. W. S. (2022). A high-resolution single-molecule sequencing-based Arabidopsis
    transcriptome using novel methods of Iso-seq analysis. <i>Genome Biology</i>.
    BioMed Central. <a href="https://doi.org/10.1186/s13059-022-02711-0">https://doi.org/10.1186/s13059-022-02711-0</a>
  chicago: Zhang, Runxuan, Richard Kuo, Max Coulter, Cristiane P.G. Calixto, Juan
    Carlos Entizne, Wenbin Guo, Yamile Marquez, et al. “A High-Resolution Single-Molecule
    Sequencing-Based Arabidopsis Transcriptome Using Novel Methods of Iso-Seq Analysis.”
    <i>Genome Biology</i>. BioMed Central, 2022. <a href="https://doi.org/10.1186/s13059-022-02711-0">https://doi.org/10.1186/s13059-022-02711-0</a>.
  ieee: R. Zhang <i>et al.</i>, “A high-resolution single-molecule sequencing-based
    Arabidopsis transcriptome using novel methods of Iso-seq analysis,” <i>Genome
    Biology</i>, vol. 23. BioMed Central, 2022.
  ista: Zhang R, Kuo R, Coulter M, Calixto CPG, Entizne JC, Guo W, Marquez Y, Milne
    L, Riegler S, Matsui A, Tanaka M, Harvey S, Gao Y, Wießner-Kroh T, Paniagua A,
    Crespi M, Denby K, Hur AB, Huq E, Jantsch M, Jarmolowski A, Koester T, Laubinger
    S, Li QQ, Gu L, Seki M, Staiger D, Sunkar R, Szweykowska-Kulinska Z, Tu SL, Wachter
    A, Waugh R, Xiong L, Zhang XN, Conesa A, Reddy ASN, Barta A, Kalyna M, Brown JWS.
    2022. A high-resolution single-molecule sequencing-based Arabidopsis transcriptome
    using novel methods of Iso-seq analysis. Genome Biology. 23, 149.
  mla: Zhang, Runxuan, et al. “A High-Resolution Single-Molecule Sequencing-Based
    Arabidopsis Transcriptome Using Novel Methods of Iso-Seq Analysis.” <i>Genome
    Biology</i>, vol. 23, 149, BioMed Central, 2022, doi:<a href="https://doi.org/10.1186/s13059-022-02711-0">10.1186/s13059-022-02711-0</a>.
  short: R. Zhang, R. Kuo, M. Coulter, C.P.G. Calixto, J.C. Entizne, W. Guo, Y. Marquez,
    L. Milne, S. Riegler, A. Matsui, M. Tanaka, S. Harvey, Y. Gao, T. Wießner-Kroh,
    A. Paniagua, M. Crespi, K. Denby, A.B. Hur, E. Huq, M. Jantsch, A. Jarmolowski,
    T. Koester, S. Laubinger, Q.Q. Li, L. Gu, M. Seki, D. Staiger, R. Sunkar, Z. Szweykowska-Kulinska,
    S.L. Tu, A. Wachter, R. Waugh, L. Xiong, X.N. Zhang, A. Conesa, A.S.N. Reddy,
    A. Barta, M. Kalyna, J.W.S. Brown, Genome Biology 23 (2022).
date_created: 2022-07-17T22:01:53Z
date_published: 2022-07-07T00:00:00Z
date_updated: 2023-08-03T12:04:18Z
day: '07'
ddc:
- '570'
department:
- _id: FyKo
doi: 10.1186/s13059-022-02711-0
external_id:
  isi:
  - '000821915500002'
file:
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  creator: dernst
  date_created: 2022-07-18T08:15:24Z
  date_updated: 2022-07-18T08:15:24Z
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has_accepted_license: '1'
intvolume: '        23'
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language:
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month: '07'
oa: 1
oa_version: Published Version
publication: Genome Biology
publication_identifier:
  eissn:
  - 1474-760X
publication_status: published
publisher: BioMed Central
quality_controlled: '1'
scopus_import: '1'
status: public
title: A high-resolution single-molecule sequencing-based Arabidopsis transcriptome
  using novel methods of Iso-seq analysis
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 23
year: '2022'
...
