---
_id: '11432'
abstract:
- lang: eng
text: "This paper proposes a method for simulating liquids in large bodies of water
by coupling together a water surface wave simulator with a 3D Navier-Stokes simulator.
The surface wave simulation uses the equivalent sources method (ESM) to efficiently
animate large bodies of water with precisely controllable wave propagation behavior.
The 3D liquid simulator animates complex non-linear fluid behaviors like splashes
and breaking waves using off-the-shelf simulators using FLIP or the level set
method with semi-Lagrangian advection.\r\nWe combine the two approaches by using
the 3D solver to animate localized non-linear behaviors, and the 2D wave solver
to animate larger regions with linear surface physics. We use the surface motion
from the 3D solver as boundary conditions for 2D surface wave simulator, and we
use the velocity and surface heights from the 2D surface wave simulator as boundary
conditions for the 3D fluid simulation. We also introduce a novel technique for
removing visual artifacts caused by numerical errors in 3D fluid solvers: we use
experimental data to estimate the artificial dispersion caused by the 3D solver
and we then carefully tune the wave speeds of the 2D solver to match it, effectively
eliminating any differences in wave behavior across the boundary. To the best
of our knowledge, this is the first time such a empirically driven error compensation
approach has been used to remove coupling errors from a physics simulator.\r\nOur
coupled simulation approach leverages the strengths of each simulation technique,
animating large environments with seamless transitions between 2D and 3D physics."
acknowledged_ssus:
- _id: ScienComp
acknowledgement: We wish to thank the anonymous reviewers and the members of the Visual
Computing Group at IST Austria and MFX Team at INRIA for their valuable feedback.
This research was supported by the Scientific Service Units (SSU) of IST Austria
through resources provided by Scientific Computing. This project has received funding
from the European Research Council (ERC) under the European Union’s Horizon 2020
research and innovation programme under grant agreement No. 638176.
article_processing_charge: No
article_type: original
author:
- first_name: Camille
full_name: Schreck, Camille
id: 2B14B676-F248-11E8-B48F-1D18A9856A87
last_name: Schreck
- first_name: Christopher J
full_name: Wojtan, Christopher J
id: 3C61F1D2-F248-11E8-B48F-1D18A9856A87
last_name: Wojtan
orcid: 0000-0001-6646-5546
citation:
ama: Schreck C, Wojtan C. Coupling 3D liquid simulation with 2D wave propagation
for large scale water surface animation using the equivalent sources method. Computer
Graphics Forum. 2022;41(2):343-353. doi:10.1111/cgf.14478
apa: Schreck, C., & Wojtan, C. (2022). Coupling 3D liquid simulation with 2D
wave propagation for large scale water surface animation using the equivalent
sources method. Computer Graphics Forum. Wiley. https://doi.org/10.1111/cgf.14478
chicago: Schreck, Camille, and Chris Wojtan. “Coupling 3D Liquid Simulation with
2D Wave Propagation for Large Scale Water Surface Animation Using the Equivalent
Sources Method.” Computer Graphics Forum. Wiley, 2022. https://doi.org/10.1111/cgf.14478.
ieee: C. Schreck and C. Wojtan, “Coupling 3D liquid simulation with 2D wave propagation
for large scale water surface animation using the equivalent sources method,”
Computer Graphics Forum, vol. 41, no. 2. Wiley, pp. 343–353, 2022.
ista: Schreck C, Wojtan C. 2022. Coupling 3D liquid simulation with 2D wave propagation
for large scale water surface animation using the equivalent sources method. Computer
Graphics Forum. 41(2), 343–353.
mla: Schreck, Camille, and Chris Wojtan. “Coupling 3D Liquid Simulation with 2D
Wave Propagation for Large Scale Water Surface Animation Using the Equivalent
Sources Method.” Computer Graphics Forum, vol. 41, no. 2, Wiley, 2022,
pp. 343–53, doi:10.1111/cgf.14478.
short: C. Schreck, C. Wojtan, Computer Graphics Forum 41 (2022) 343–353.
date_created: 2022-06-05T22:01:49Z
date_published: 2022-05-01T00:00:00Z
date_updated: 2023-08-02T06:44:05Z
day: '01'
department:
- _id: ChWo
doi: 10.1111/cgf.14478
ec_funded: 1
external_id:
isi:
- '000802723900027'
intvolume: ' 41'
isi: 1
issue: '2'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://hal.archives-ouvertes.fr/hal-03641349/
month: '05'
oa: 1
oa_version: Submitted Version
page: 343-353
project:
- _id: 2533E772-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '638176'
name: Efficient Simulation of Natural Phenomena at Extremely Large Scales
publication: Computer Graphics Forum
publication_identifier:
eissn:
- 1467-8659
issn:
- 0167-7055
publication_status: published
publisher: Wiley
quality_controlled: '1'
scopus_import: '1'
status: public
title: Coupling 3D liquid simulation with 2D wave propagation for large scale water
surface animation using the equivalent sources method
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 41
year: '2022'
...
---
_id: '11435'
abstract:
- lang: eng
text: 'We introduce a new variant of quantitative Helly-type theorems: the minimal
homothetic distance of the intersection of a family of convex sets to the intersection
of a subfamily of a fixed size. As an application, we establish the following
quantitative Helly-type result for the diameter. If $K$ is the intersection of
finitely many convex bodies in $\mathbb{R}^d$, then one can select $2d$ of these
bodies whose intersection is of diameter at most $(2d)^3{diam}(K)$. The best previously
known estimate, due to Brazitikos [Bull. Hellenic Math. Soc., 62 (2018), pp. 19--25],
is $c d^{11/2}$. Moreover, we confirm that the multiplicative factor $c d^{1/2}$
conjectured by Bárány, Katchalski, and Pach [Proc. Amer. Math. Soc., 86 (1982),
pp. 109--114] cannot be improved. The bounds above follow from our key result
that concerns sparse approximation of a convex polytope by the convex hull of
a well-chosen subset of its vertices: Assume that $Q \subset {\mathbb R}^d$ is
a polytope whose centroid is the origin. Then there exist at most 2d vertices
of $Q$ whose convex hull $Q^{\prime \prime}$ satisfies $Q \subset - 8d^3 Q^{\prime
\prime}.$'
acknowledgement: "G.I. acknowledges the financial support from the Ministry of Educational
and Science of the Russian Federation in the framework of MegaGrant no 075-15-2019-1926.
M.N. was supported by the National Research, Development and Innovation Fund (NRDI)
grants K119670 and\r\nKKP-133864 as well as the Bolyai Scholarship of the Hungarian
Academy of Sciences and the New National Excellence Programme and the TKP2020-NKA-06
program provided by the NRDI."
article_processing_charge: No
article_type: original
arxiv: 1
author:
- first_name: Grigory
full_name: Ivanov, Grigory
id: 87744F66-5C6F-11EA-AFE0-D16B3DDC885E
last_name: Ivanov
- first_name: Marton
full_name: Naszodi, Marton
last_name: Naszodi
citation:
ama: 'Ivanov G, Naszodi M. A quantitative Helly-type theorem: Containment in a homothet.
SIAM Journal on Discrete Mathematics. 2022;36(2):951-957. doi:10.1137/21M1403308'
apa: 'Ivanov, G., & Naszodi, M. (2022). A quantitative Helly-type theorem: Containment
in a homothet. SIAM Journal on Discrete Mathematics. Society for Industrial
and Applied Mathematics. https://doi.org/10.1137/21M1403308'
chicago: 'Ivanov, Grigory, and Marton Naszodi. “A Quantitative Helly-Type Theorem:
Containment in a Homothet.” SIAM Journal on Discrete Mathematics. Society
for Industrial and Applied Mathematics, 2022. https://doi.org/10.1137/21M1403308.'
ieee: 'G. Ivanov and M. Naszodi, “A quantitative Helly-type theorem: Containment
in a homothet,” SIAM Journal on Discrete Mathematics, vol. 36, no. 2. Society
for Industrial and Applied Mathematics, pp. 951–957, 2022.'
ista: 'Ivanov G, Naszodi M. 2022. A quantitative Helly-type theorem: Containment
in a homothet. SIAM Journal on Discrete Mathematics. 36(2), 951–957.'
mla: 'Ivanov, Grigory, and Marton Naszodi. “A Quantitative Helly-Type Theorem: Containment
in a Homothet.” SIAM Journal on Discrete Mathematics, vol. 36, no. 2, Society
for Industrial and Applied Mathematics, 2022, pp. 951–57, doi:10.1137/21M1403308.'
short: G. Ivanov, M. Naszodi, SIAM Journal on Discrete Mathematics 36 (2022) 951–957.
date_created: 2022-06-05T22:01:50Z
date_published: 2022-04-11T00:00:00Z
date_updated: 2023-10-18T06:58:03Z
day: '11'
department:
- _id: UlWa
doi: 10.1137/21M1403308
external_id:
arxiv:
- '2103.04122'
isi:
- '000793158200002'
intvolume: ' 36'
isi: 1
issue: '2'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: ' https://doi.org/10.48550/arXiv.2103.04122'
month: '04'
oa: 1
oa_version: Preprint
page: 951-957
publication: SIAM Journal on Discrete Mathematics
publication_identifier:
issn:
- 0895-4801
publication_status: published
publisher: Society for Industrial and Applied Mathematics
quality_controlled: '1'
scopus_import: '1'
status: public
title: 'A quantitative Helly-type theorem: Containment in a homothet'
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 36
year: '2022'
...
---
_id: '11438'
abstract:
- lang: eng
text: Lasers with well-controlled relative frequencies are indispensable for many
applications in science and technology. We present a frequency-offset locking
method for lasers based on beat-frequency discrimination utilizing hybrid electronic
LC filters. The method is specifically designed for decoupling the tightness of
the lock from the broadness of its capture range. The presented demonstration
locks two free-running diode lasers at 780 nm with a 5.5-GHz offset. It displays
an offset frequency instability below 55 Hz for time scales in excess of 1000
s and a minimum of 12 Hz at 10-s averaging. The performance is complemented with
a 190-MHz lock-capture range, a tuning range of up to 1 GHz, and a frequency ramp
agility of 200kHz/μs.
acknowledgement: This work was supported by IST Austria. The authors thank Yueheng
Shi for technical contributions.
article_number: '054031'
article_processing_charge: No
article_type: original
arxiv: 1
author:
- first_name: Vyacheslav
full_name: Li, Vyacheslav
id: 3A4FAA92-F248-11E8-B48F-1D18A9856A87
last_name: Li
- first_name: Fritz R
full_name: Diorico, Fritz R
id: 2E054C4C-F248-11E8-B48F-1D18A9856A87
last_name: Diorico
- first_name: Onur
full_name: Hosten, Onur
id: 4C02D85E-F248-11E8-B48F-1D18A9856A87
last_name: Hosten
orcid: 0000-0002-2031-204X
citation:
ama: Li V, Diorico FR, Hosten O. Laser frequency-offset locking at 10-Hz-level instability
using hybrid electronic filters. Physical Review Applied. 2022;17(5). doi:10.1103/physrevapplied.17.054031
apa: Li, V., Diorico, F. R., & Hosten, O. (2022). Laser frequency-offset locking
at 10-Hz-level instability using hybrid electronic filters. Physical Review
Applied. American Physical Society. https://doi.org/10.1103/physrevapplied.17.054031
chicago: Li, Vyacheslav, Fritz R Diorico, and Onur Hosten. “Laser Frequency-Offset
Locking at 10-Hz-Level Instability Using Hybrid Electronic Filters.” Physical
Review Applied. American Physical Society, 2022. https://doi.org/10.1103/physrevapplied.17.054031.
ieee: V. Li, F. R. Diorico, and O. Hosten, “Laser frequency-offset locking at 10-Hz-level
instability using hybrid electronic filters,” Physical Review Applied,
vol. 17, no. 5. American Physical Society, 2022.
ista: Li V, Diorico FR, Hosten O. 2022. Laser frequency-offset locking at 10-Hz-level
instability using hybrid electronic filters. Physical Review Applied. 17(5), 054031.
mla: Li, Vyacheslav, et al. “Laser Frequency-Offset Locking at 10-Hz-Level Instability
Using Hybrid Electronic Filters.” Physical Review Applied, vol. 17, no.
5, 054031, American Physical Society, 2022, doi:10.1103/physrevapplied.17.054031.
short: V. Li, F.R. Diorico, O. Hosten, Physical Review Applied 17 (2022).
date_created: 2022-06-07T08:07:59Z
date_published: 2022-05-19T00:00:00Z
date_updated: 2023-08-03T07:18:34Z
day: '19'
department:
- _id: GradSch
- _id: OnHo
doi: 10.1103/physrevapplied.17.054031
external_id:
arxiv:
- '2111.13194'
isi:
- '000880670300001'
intvolume: ' 17'
isi: 1
issue: '5'
keyword:
- General Physics and Astronomy
language:
- iso: eng
main_file_link:
- open_access: '1'
url: ' https://doi.org/10.48550/arXiv.2111.13194'
month: '05'
oa: 1
oa_version: Preprint
publication: Physical Review Applied
publication_identifier:
issn:
- 2331-7019
publication_status: published
publisher: American Physical Society
quality_controlled: '1'
status: public
title: Laser frequency-offset locking at 10-Hz-level instability using hybrid electronic
filters
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 17
year: '2022'
...
---
_id: '11440'
abstract:
- lang: eng
text: To compute the persistent homology of a grayscale digital image one needs
to build a simplicial or cubical complex from it. For cubical complexes, the two
commonly used constructions (corresponding to direct and indirect digital adjacencies)
can give different results for the same image. The two constructions are almost
dual to each other, and we use this relationship to extend and modify the cubical
complexes to become dual filtered cell complexes. We derive a general relationship
between the persistent homology of two dual filtered cell complexes, and also
establish how various modifications to a filtered complex change the persistence
diagram. Applying these results to images, we derive a method to transform the
persistence diagram computed using one type of cubical complex into a persistence
diagram for the other construction. This means software for computing persistent
homology from images can now be easily adapted to produce results for either of
the two cubical complex constructions without additional low-level code implementation.
acknowledgement: This project started during the Women in Computational Topology workshop
held in Canberra in July of 2019. All authors are very grateful for its organisation
and the financial support for the workshop from the Mathematical Sciences Institute
at ANU, the US National Science Foundation through the award CCF-1841455, the Australian
Mathematical Sciences Institute and the Association for Women in Mathematics. AG
is supported by the Swiss National Science Foundation grant CRSII5_177237. TH is
supported by the European Research Council (ERC) Horizon 2020 project “Alpha Shape
Theory Extended” No. 788183. KM is supported by the ERC Horizon 2020 research and
innovation programme under the Marie Sklodowska-Curie grant agreement No. 859860.
VR was supported by Australian Research Council Future Fellowship FT140100604 during
the early stages of this project.
alternative_title:
- Association for Women in Mathematics Series
article_processing_charge: No
arxiv: 1
author:
- first_name: Bea
full_name: Bleile, Bea
last_name: Bleile
- first_name: Adélie
full_name: Garin, Adélie
last_name: Garin
- first_name: Teresa
full_name: Heiss, Teresa
id: 4879BB4E-F248-11E8-B48F-1D18A9856A87
last_name: Heiss
orcid: 0000-0002-1780-2689
- first_name: Kelly
full_name: Maggs, Kelly
last_name: Maggs
- first_name: Vanessa
full_name: Robins, Vanessa
last_name: Robins
citation:
ama: 'Bleile B, Garin A, Heiss T, Maggs K, Robins V. The persistent homology of
dual digital image constructions. In: Gasparovic E, Robins V, Turner K, eds. Research
in Computational Topology 2. Vol 30. 1st ed. AWMS. Cham: Springer Nature;
2022:1-26. doi:10.1007/978-3-030-95519-9_1'
apa: 'Bleile, B., Garin, A., Heiss, T., Maggs, K., & Robins, V. (2022). The
persistent homology of dual digital image constructions. In E. Gasparovic, V.
Robins, & K. Turner (Eds.), Research in Computational Topology 2 (1st
ed., Vol. 30, pp. 1–26). Cham: Springer Nature. https://doi.org/10.1007/978-3-030-95519-9_1'
chicago: 'Bleile, Bea, Adélie Garin, Teresa Heiss, Kelly Maggs, and Vanessa Robins.
“The Persistent Homology of Dual Digital Image Constructions.” In Research
in Computational Topology 2, edited by Ellen Gasparovic, Vanessa Robins, and
Katharine Turner, 1st ed., 30:1–26. AWMS. Cham: Springer Nature, 2022. https://doi.org/10.1007/978-3-030-95519-9_1.'
ieee: 'B. Bleile, A. Garin, T. Heiss, K. Maggs, and V. Robins, “The persistent homology
of dual digital image constructions,” in Research in Computational Topology
2, 1st ed., vol. 30, E. Gasparovic, V. Robins, and K. Turner, Eds. Cham: Springer
Nature, 2022, pp. 1–26.'
ista: 'Bleile B, Garin A, Heiss T, Maggs K, Robins V. 2022.The persistent homology
of dual digital image constructions. In: Research in Computational Topology 2.
Association for Women in Mathematics Series, vol. 30, 1–26.'
mla: Bleile, Bea, et al. “The Persistent Homology of Dual Digital Image Constructions.”
Research in Computational Topology 2, edited by Ellen Gasparovic et al.,
1st ed., vol. 30, Springer Nature, 2022, pp. 1–26, doi:10.1007/978-3-030-95519-9_1.
short: B. Bleile, A. Garin, T. Heiss, K. Maggs, V. Robins, in:, E. Gasparovic, V.
Robins, K. Turner (Eds.), Research in Computational Topology 2, 1st ed., Springer
Nature, Cham, 2022, pp. 1–26.
date_created: 2022-06-07T08:21:11Z
date_published: 2022-01-27T00:00:00Z
date_updated: 2022-06-07T08:32:42Z
day: '27'
department:
- _id: HeEd
doi: 10.1007/978-3-030-95519-9_1
ec_funded: 1
edition: '1'
editor:
- first_name: Ellen
full_name: Gasparovic, Ellen
last_name: Gasparovic
- first_name: Vanessa
full_name: Robins, Vanessa
last_name: Robins
- first_name: Katharine
full_name: Turner, Katharine
last_name: Turner
external_id:
arxiv:
- '2102.11397'
intvolume: ' 30'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: ' https://doi.org/10.48550/arXiv.2102.11397'
month: '01'
oa: 1
oa_version: Preprint
page: 1-26
place: Cham
project:
- _id: 266A2E9E-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '788183'
name: Alpha Shape Theory Extended
publication: Research in Computational Topology 2
publication_identifier:
eisbn:
- '9783030955199'
isbn:
- '9783030955182'
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
scopus_import: '1'
series_title: AWMS
status: public
title: The persistent homology of dual digital image constructions
type: book_chapter
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 30
year: '2022'
...
---
_id: '11442'
abstract:
- lang: eng
text: "Enabling additive manufacturing to employ a wide range of novel, functional
materials can be a major boost to this technology. However, making such materials
printable requires painstaking trial-and-error by an expert operator,\r\nas they
typically tend to exhibit peculiar rheological or hysteresis properties. Even
in the case of successfully finding the process parameters, there is no guarantee
of print-to-print consistency due to material differences between batches. These
challenges make closed-loop feedback an attractive option where the process parameters
are adjusted on-the-fly. There are several challenges for designing an efficient
controller: the deposition parameters are complex and highly coupled, artifacts
occur after long time horizons, simulating the deposition is computationally costly,
and learning on hardware is intractable. In this work, we demonstrate the feasibility
of learning a closed-loop control policy for additive manufacturing using reinforcement
learning. We show that approximate, but efficient, numerical simulation is\r\nsufficient
as long as it allows learning the behavioral patterns of deposition that translate
to real-world experiences. In combination with reinforcement learning, our model
can be used to discover control policies that outperform\r\nbaseline controllers.
Furthermore, the recovered policies have a minimal sim-to-real gap. We showcase
this by applying our control policy in-vivo on a single-layer, direct ink writing
printer. "
acknowledgement: "This work is graciously supported by the following grant agencies:
FWF Lise Meitner (Grant M 3319), SNSF (Grant 200502), ERC Starting Grant (MATERIALIZABLE-715767),
NSF (Grant IIS-181507).\r\n"
article_number: '112'
article_processing_charge: No
article_type: original
arxiv: 1
author:
- first_name: Michael
full_name: Piovarci, Michael
id: 62E473F4-5C99-11EA-A40E-AF823DDC885E
last_name: Piovarci
- first_name: Michael
full_name: Foshey, Michael
last_name: Foshey
- first_name: Jie
full_name: Xu, Jie
last_name: Xu
- first_name: Timothy
full_name: Erps, Timothy
last_name: Erps
- first_name: Vahid
full_name: Babaei, Vahid
last_name: Babaei
- first_name: Piotr
full_name: Didyk, Piotr
last_name: Didyk
- first_name: Szymon
full_name: Rusinkiewicz, Szymon
last_name: Rusinkiewicz
- first_name: Wojciech
full_name: Matusik, Wojciech
last_name: Matusik
- first_name: Bernd
full_name: Bickel, Bernd
id: 49876194-F248-11E8-B48F-1D18A9856A87
last_name: Bickel
orcid: 0000-0001-6511-9385
citation:
ama: Piovarci M, Foshey M, Xu J, et al. Closed-loop control of direct ink writing
via reinforcement learning. ACM Transactions on Graphics. 2022;41(4). doi:10.1145/3528223.3530144
apa: Piovarci, M., Foshey, M., Xu, J., Erps, T., Babaei, V., Didyk, P., … Bickel,
B. (2022). Closed-loop control of direct ink writing via reinforcement learning.
ACM Transactions on Graphics. Association for Computing Machinery. https://doi.org/10.1145/3528223.3530144
chicago: Piovarci, Michael, Michael Foshey, Jie Xu, Timothy Erps, Vahid Babaei,
Piotr Didyk, Szymon Rusinkiewicz, Wojciech Matusik, and Bernd Bickel. “Closed-Loop
Control of Direct Ink Writing via Reinforcement Learning.” ACM Transactions
on Graphics. Association for Computing Machinery, 2022. https://doi.org/10.1145/3528223.3530144.
ieee: M. Piovarci et al., “Closed-loop control of direct ink writing via
reinforcement learning,” ACM Transactions on Graphics, vol. 41, no. 4.
Association for Computing Machinery, 2022.
ista: Piovarci M, Foshey M, Xu J, Erps T, Babaei V, Didyk P, Rusinkiewicz S, Matusik
W, Bickel B. 2022. Closed-loop control of direct ink writing via reinforcement
learning. ACM Transactions on Graphics. 41(4), 112.
mla: Piovarci, Michael, et al. “Closed-Loop Control of Direct Ink Writing via Reinforcement
Learning.” ACM Transactions on Graphics, vol. 41, no. 4, 112, Association
for Computing Machinery, 2022, doi:10.1145/3528223.3530144.
short: M. Piovarci, M. Foshey, J. Xu, T. Erps, V. Babaei, P. Didyk, S. Rusinkiewicz,
W. Matusik, B. Bickel, ACM Transactions on Graphics 41 (2022).
date_created: 2022-06-10T06:41:47Z
date_published: 2022-06-01T00:00:00Z
date_updated: 2023-05-31T12:38:21Z
day: '01'
ddc:
- '000'
department:
- _id: BeBi
doi: 10.1145/3528223.3530144
ec_funded: 1
external_id:
arxiv:
- '2201.11819'
file:
- access_level: open_access
checksum: 27f6fe41c6ff84d50445cc9b0176d45b
content_type: application/pdf
creator: dernst
date_created: 2022-06-28T08:32:58Z
date_updated: 2022-06-28T08:32:58Z
file_id: '11467'
file_name: 2022_ACM_acceptedversion_Piovarci.pdf
file_size: 33994829
relation: main_file
success: 1
file_date_updated: 2022-06-28T08:32:58Z
has_accepted_license: '1'
intvolume: ' 41'
issue: '4'
language:
- iso: eng
month: '06'
oa: 1
oa_version: Submitted Version
project:
- _id: eb901961-77a9-11ec-83b8-f5c883a62027
grant_number: M03319
name: Perception-Aware Appearance Fabrication
- _id: 24F9549A-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '715767'
name: 'MATERIALIZABLE: Intelligent fabrication-oriented Computational Design and
Modeling'
publication: ACM Transactions on Graphics
publication_identifier:
eissn:
- 1557-7368
issn:
- 0730-0301
publication_status: published
publisher: Association for Computing Machinery
quality_controlled: '1'
related_material:
link:
- description: News on ISTA website
relation: press_release
url: https://ista.ac.at/en/news/machine-learning-3d-printing-fluids/
status: public
title: Closed-loop control of direct ink writing via reinforcement learning
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 41
year: '2022'
...
---
_id: '11443'
abstract:
- lang: eng
text: Sometimes, it is possible to represent a complicated polytope as a projection
of a much simpler polytope. To quantify this phenomenon, the extension complexity
of a polytope P is defined to be the minimum number of facets of a (possibly higher-dimensional)
polytope from which P can be obtained as a (linear) projection. This notion is
motivated by its relevance to combinatorial optimisation, and has been studied
intensively for various specific polytopes associated with important optimisation
problems. In this paper we study extension complexity as a parameter of general
polytopes, more specifically considering various families of low-dimensional polytopes.
First, we prove that for a fixed dimension d, the extension complexity of a random
d-dimensional polytope (obtained as the convex hull of random points in a ball
or on a sphere) is typically on the order of the square root of its number of
vertices. Second, we prove that any cyclic n-vertex polygon (whose vertices lie
on a circle) has extension complexity at most 24√n. This bound is tight up to
the constant factor 24. Finally, we show that there exists an no(1)-dimensional
polytope with at most n vertices and extension complexity n1−o(1). Our theorems
are proved with a range of different techniques, which we hope will be of further
interest.
acknowledgement: "The research of the first author was supported by SNSF Project 178493
and NSF Award DMS-1953990. The research of the second author supported by NSF Award
DMS-1953772.\r\nThe research of the third author was supported by NSF Award DMS-1764176,
NSF CAREER Award DMS-2044606, a Sloan Research Fellowship, and the MIT Solomon Buchsbaum
Fund. "
article_processing_charge: No
article_type: original
arxiv: 1
author:
- first_name: Matthew Alan
full_name: Kwan, Matthew Alan
id: 5fca0887-a1db-11eb-95d1-ca9d5e0453b3
last_name: Kwan
orcid: 0000-0002-4003-7567
- first_name: Lisa
full_name: Sauermann, Lisa
last_name: Sauermann
- first_name: Yufei
full_name: Zhao, Yufei
last_name: Zhao
citation:
ama: Kwan MA, Sauermann L, Zhao Y. Extension complexity of low-dimensional polytopes.
Transactions of the American Mathematical Society. 2022;375(6):4209-4250.
doi:10.1090/tran/8614
apa: Kwan, M. A., Sauermann, L., & Zhao, Y. (2022). Extension complexity of
low-dimensional polytopes. Transactions of the American Mathematical Society.
American Mathematical Society. https://doi.org/10.1090/tran/8614
chicago: Kwan, Matthew Alan, Lisa Sauermann, and Yufei Zhao. “Extension Complexity
of Low-Dimensional Polytopes.” Transactions of the American Mathematical Society.
American Mathematical Society, 2022. https://doi.org/10.1090/tran/8614.
ieee: M. A. Kwan, L. Sauermann, and Y. Zhao, “Extension complexity of low-dimensional
polytopes,” Transactions of the American Mathematical Society, vol. 375,
no. 6. American Mathematical Society, pp. 4209–4250, 2022.
ista: Kwan MA, Sauermann L, Zhao Y. 2022. Extension complexity of low-dimensional
polytopes. Transactions of the American Mathematical Society. 375(6), 4209–4250.
mla: Kwan, Matthew Alan, et al. “Extension Complexity of Low-Dimensional Polytopes.”
Transactions of the American Mathematical Society, vol. 375, no. 6, American
Mathematical Society, 2022, pp. 4209–50, doi:10.1090/tran/8614.
short: M.A. Kwan, L. Sauermann, Y. Zhao, Transactions of the American Mathematical
Society 375 (2022) 4209–4250.
date_created: 2022-06-12T22:01:45Z
date_published: 2022-06-01T00:00:00Z
date_updated: 2023-08-03T07:17:37Z
day: '01'
department:
- _id: MaKw
doi: 10.1090/tran/8614
external_id:
arxiv:
- '2006.08836'
isi:
- '000798461500001'
intvolume: ' 375'
isi: 1
issue: '6'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: ' https://doi.org/10.48550/arXiv.2006.08836'
month: '06'
oa: 1
oa_version: Preprint
page: 4209-4250
publication: Transactions of the American Mathematical Society
publication_identifier:
eissn:
- 1088-6850
issn:
- 0002-9947
publication_status: published
publisher: American Mathematical Society
quality_controlled: '1'
scopus_import: '1'
status: public
title: Extension complexity of low-dimensional polytopes
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 375
year: '2022'
...
---
_id: '11444'
abstract:
- lang: eng
text: "This article investigates library-related documents written by Gerard van
Swieten (1700–72) during his tenure as Library Prefect in the Imperial Library
of Vienna (1745–72). Van Swieten’s time as Library Prefect is considered through
a textual analysis. Handwritten letters were deconstructed in terms of their appearance,
layout, and tone in order to mine them for meaning. Furthermore, the contents
were examined for library matters such as censorship, catalogues, and collection
development. The Imperial Court Library held a prominent role as a repository
for rare and valuable works, later becoming the National Library of Austria.\r\nGerard
van Swieten’s work as a librarian tends to be overlooked, perhaps because he is
better known as the private physician of Maria Theresia, as well as a medical
reformer. Nevertheless, he was a hard-working chief librarian deeply involved
in all aspects of librarianship. Van Swieten endorsed modern scientific works,
which were otherwise banned officially by the censorship commission, for the use
of scholars in the library, expanded the collection by acquiring books through
his network of scholars and publishers, and reissued library catalogues. He also
provided for the comfort of users in the library reading room, at a time when
such considerations were unusual. In conclusion, a proposal is made that van Swieten
viewed his role as librarian with some importance and pride."
article_processing_charge: No
article_type: original
author:
- first_name: Clara A
full_name: Chlebak, Clara A
id: 8b945eb4-e2f2-11eb-945a-df72226e66a9
last_name: Chlebak
orcid: 0000-0002-3385-3865
- first_name: Peter H.
full_name: Reid, Peter H.
last_name: Reid
citation:
ama: 'Chlebak CA, Reid PH. From the prefect’s desk: Gerard van Swieten’s library
correspondence. Library and Information History. 2022;38(1):23-41. doi:10.3366/lih.2022.0097'
apa: 'Chlebak, C. A., & Reid, P. H. (2022). From the prefect’s desk: Gerard
van Swieten’s library correspondence. Library and Information History.
Edinburgh University Press. https://doi.org/10.3366/lih.2022.0097'
chicago: 'Chlebak, Clara A, and Peter H. Reid. “From the Prefect’s Desk: Gerard
van Swieten’s Library Correspondence.” Library and Information History.
Edinburgh University Press, 2022. https://doi.org/10.3366/lih.2022.0097.'
ieee: 'C. A. Chlebak and P. H. Reid, “From the prefect’s desk: Gerard van Swieten’s
library correspondence,” Library and Information History, vol. 38, no.
1. Edinburgh University Press, pp. 23–41, 2022.'
ista: 'Chlebak CA, Reid PH. 2022. From the prefect’s desk: Gerard van Swieten’s
library correspondence. Library and Information History. 38(1), 23–41.'
mla: 'Chlebak, Clara A., and Peter H. Reid. “From the Prefect’s Desk: Gerard van
Swieten’s Library Correspondence.” Library and Information History, vol.
38, no. 1, Edinburgh University Press, 2022, pp. 23–41, doi:10.3366/lih.2022.0097.'
short: C.A. Chlebak, P.H. Reid, Library and Information History 38 (2022) 23–41.
date_created: 2022-06-12T22:01:45Z
date_published: 2022-04-01T00:00:00Z
date_updated: 2023-02-21T09:51:29Z
day: '01'
department:
- _id: E-Lib
doi: 10.3366/lih.2022.0097
intvolume: ' 38'
issue: '1'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://rgu-repository.worktribe.com/output/1635939
month: '04'
oa: 1
oa_version: Submitted Version
page: 23-41
publication: Library and Information History
publication_identifier:
eissn:
- 1758-3497
issn:
- 1758-3489
publication_status: published
publisher: Edinburgh University Press
quality_controlled: '1'
scopus_import: '1'
status: public
title: 'From the prefect’s desk: Gerard van Swieten’s library correspondence'
type: journal_article
user_id: 8b945eb4-e2f2-11eb-945a-df72226e66a9
volume: 38
year: '2022'
...
---
_id: '11447'
abstract:
- lang: eng
text: Empirical essays of fitness landscapes suggest that they may be rugged, that
is having multiple fitness peaks. Such fitness landscapes, those that have multiple
peaks, necessarily have special local structures, called reciprocal sign epistasis
(Poelwijk et al. in J Theor Biol 272:141–144, 2011). Here, we investigate the
quantitative relationship between the number of fitness peaks and the number of
reciprocal sign epistatic interactions. Previously, it has been shown (Poelwijk
et al. in J Theor Biol 272:141–144, 2011) that pairwise reciprocal sign epistasis
is a necessary but not sufficient condition for the existence of multiple peaks.
Applying discrete Morse theory, which to our knowledge has never been used in
this context, we extend this result by giving the minimal number of reciprocal
sign epistatic interactions required to create a given number of peaks.
acknowledgement: We are grateful to Herbert Edelsbrunner and Jeferson Zapata for helpful
discussions. Open access funding provided by Austrian Science Fund (FWF). Partially
supported by the ERC Consolidator (771209–CharFL) and the FWF Austrian Science Fund
(I5127-B) grants to FAK.
article_number: '74'
article_processing_charge: Yes (via OA deal)
article_type: original
author:
- first_name: Raimundo J
full_name: Saona Urmeneta, Raimundo J
id: BD1DF4C4-D767-11E9-B658-BC13E6697425
last_name: Saona Urmeneta
orcid: 0000-0001-5103-038X
- first_name: Fyodor
full_name: Kondrashov, Fyodor
id: 44FDEF62-F248-11E8-B48F-1D18A9856A87
last_name: Kondrashov
orcid: 0000-0001-8243-4694
- first_name: Kseniia
full_name: Khudiakova, Kseniia
id: 4E6DC800-AE37-11E9-AC72-31CAE5697425
last_name: Khudiakova
orcid: 0000-0002-6246-1465
citation:
ama: Saona Urmeneta RJ, Kondrashov F, Khudiakova K. Relation between the number
of peaks and the number of reciprocal sign epistatic interactions. Bulletin
of Mathematical Biology. 2022;84(8). doi:10.1007/s11538-022-01029-z
apa: Saona Urmeneta, R. J., Kondrashov, F., & Khudiakova, K. (2022). Relation
between the number of peaks and the number of reciprocal sign epistatic interactions.
Bulletin of Mathematical Biology. Springer Nature. https://doi.org/10.1007/s11538-022-01029-z
chicago: Saona Urmeneta, Raimundo J, Fyodor Kondrashov, and Kseniia Khudiakova.
“Relation between the Number of Peaks and the Number of Reciprocal Sign Epistatic
Interactions.” Bulletin of Mathematical Biology. Springer Nature, 2022.
https://doi.org/10.1007/s11538-022-01029-z.
ieee: R. J. Saona Urmeneta, F. Kondrashov, and K. Khudiakova, “Relation between
the number of peaks and the number of reciprocal sign epistatic interactions,”
Bulletin of Mathematical Biology, vol. 84, no. 8. Springer Nature, 2022.
ista: Saona Urmeneta RJ, Kondrashov F, Khudiakova K. 2022. Relation between the
number of peaks and the number of reciprocal sign epistatic interactions. Bulletin
of Mathematical Biology. 84(8), 74.
mla: Saona Urmeneta, Raimundo J., et al. “Relation between the Number of Peaks and
the Number of Reciprocal Sign Epistatic Interactions.” Bulletin of Mathematical
Biology, vol. 84, no. 8, 74, Springer Nature, 2022, doi:10.1007/s11538-022-01029-z.
short: R.J. Saona Urmeneta, F. Kondrashov, K. Khudiakova, Bulletin of Mathematical
Biology 84 (2022).
date_created: 2022-06-17T16:16:15Z
date_published: 2022-06-17T00:00:00Z
date_updated: 2023-08-03T07:20:53Z
day: '17'
ddc:
- '510'
- '570'
department:
- _id: GradSch
- _id: NiBa
- _id: JaMa
doi: 10.1007/s11538-022-01029-z
ec_funded: 1
external_id:
isi:
- '000812509800001'
file:
- access_level: open_access
checksum: 05a1fe7d10914a00c2bca9b447993a65
content_type: application/pdf
creator: dernst
date_created: 2022-06-20T07:51:32Z
date_updated: 2022-06-20T07:51:32Z
file_id: '11455'
file_name: 2022_BulletinMathBiology_Saona.pdf
file_size: 463025
relation: main_file
success: 1
file_date_updated: 2022-06-20T07:51:32Z
has_accepted_license: '1'
intvolume: ' 84'
isi: 1
issue: '8'
keyword:
- Computational Theory and Mathematics
- General Agricultural and Biological Sciences
- Pharmacology
- General Environmental Science
- General Biochemistry
- Genetics and Molecular Biology
- General Mathematics
- Immunology
- General Neuroscience
language:
- iso: eng
month: '06'
oa: 1
oa_version: Published Version
project:
- _id: 26580278-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '771209'
name: Characterizing the fitness landscape on population and global scales
- _id: c098eddd-5a5b-11eb-8a69-abe27170a68f
grant_number: I05127
name: Evolutionary analysis of gene regulation
publication: Bulletin of Mathematical Biology
publication_identifier:
eissn:
- 1522-9602
issn:
- 0092-8240
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
related_material:
link:
- relation: erratum
url: https://doi.org/10.1007/s11538-022-01118-z
scopus_import: '1'
status: public
title: Relation between the number of peaks and the number of reciprocal sign epistatic
interactions
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 84
year: '2022'
...
---
_id: '11448'
abstract:
- lang: eng
text: Studies of protein fitness landscapes reveal biophysical constraints guiding
protein evolution and empower prediction of functional proteins. However, generalisation
of these findings is limited due to scarceness of systematic data on fitness landscapes
of proteins with a defined evolutionary relationship. We characterized the fitness
peaks of four orthologous fluorescent proteins with a broad range of sequence
divergence. While two of the four studied fitness peaks were sharp, the other
two were considerably flatter, being almost entirely free of epistatic interactions.
Mutationally robust proteins, characterized by a flat fitness peak, were not optimal
templates for machine-learning-driven protein design – instead, predictions were
more accurate for fragile proteins with epistatic landscapes. Our work paves insights
for practical application of fitness landscape heterogeneity in protein engineering.
acknowledged_ssus:
- _id: LifeSc
- _id: Bio
acknowledgement: "We thank Ondřej Draganov, Rodrigo Redondo, Bor Kavčič, Mia Juračić
and Andrea Pauli for discussion and technical advice. We thank Anita Testa Salmazo
for advice on resin protein purification, Dmitry Bolotin and the Milaboratory (milaboratory.com)
for access to computing and storage infrastructure, and Josef Houser and Eva Fujdiarova
for technical assistance and data interpretation. Core facility Biomolecular Interactions
and Crystallization of CEITEC Masaryk University is gratefully acknowledged for
the obtaining of the scientific data presented in this paper. This research was
supported by the Scientific Service Units (SSU) of IST-Austria\r\nthrough resources
provided by the Bioimaging Facility (BIF), and the Life Science Facility (LSF).
MiSeq and HiSeq NGS sequencing was performed by the Next Generation Sequencing Facility
at Vienna BioCenter Core Facilities (VBCF), member of the Vienna BioCenter (VBC),
Austria. FACS was performed at the BioOptics Facility of the Institute of Molecular
Pathology (IMP), Austria. We also thank the Biomolecular Crystallography Facility
in the Vanderbilt University Center for Structural Biology. We are grateful to Joel
M Harp for help with X-ray data collection. This work was supported by the ERC Consolidator
grant to FAK (771209—CharFL). KSS acknowledges support by President’s Grant МК–5405.2021.1.4,
the Imperial College Research Fellowship and the MRC London Institute of Medical
Sciences (UKRI MC-A658-5QEA0).\r\nAF is supported by the Marie Skłodowska-Curie
Fellowship (H2020-MSCA-IF-2019, Grant Agreement No. 898203, Project acronym \"FLINDIP\").
Experiments were partially carried out using equipment provided by the Institute
of Bioorganic Chemistry of the Russian Academy of Sciences Сore Facility (CKP IBCH).
This work was supported by a Russian Science Foundation grant 19-74-10102.This project
has received funding from the European Union’s Horizon 2020 research and innovation
programme under the Marie Skłodowska-Curie Grant Agreement No. 665,385."
article_number: '75842'
article_processing_charge: No
article_type: original
author:
- first_name: Louisa
full_name: Gonzalez Somermeyer, Louisa
id: 4720D23C-F248-11E8-B48F-1D18A9856A87
last_name: Gonzalez Somermeyer
orcid: 0000-0001-9139-5383
- first_name: Aubin
full_name: Fleiss, Aubin
last_name: Fleiss
- first_name: Alexander S
full_name: Mishin, Alexander S
last_name: Mishin
- first_name: Nina G
full_name: Bozhanova, Nina G
last_name: Bozhanova
- first_name: Anna A
full_name: Igolkina, Anna A
last_name: Igolkina
- first_name: Jens
full_name: Meiler, Jens
last_name: Meiler
- first_name: Maria-Elisenda
full_name: Alaball Pujol, Maria-Elisenda
last_name: Alaball Pujol
- first_name: Ekaterina V
full_name: Putintseva, Ekaterina V
last_name: Putintseva
- first_name: Karen S
full_name: Sarkisyan, Karen S
last_name: Sarkisyan
- first_name: Fyodor
full_name: Kondrashov, Fyodor
id: 44FDEF62-F248-11E8-B48F-1D18A9856A87
last_name: Kondrashov
orcid: 0000-0001-8243-4694
citation:
ama: Gonzalez Somermeyer L, Fleiss A, Mishin AS, et al. Heterogeneity of the GFP
fitness landscape and data-driven protein design. eLife. 2022;11. doi:10.7554/elife.75842
apa: Gonzalez Somermeyer, L., Fleiss, A., Mishin, A. S., Bozhanova, N. G., Igolkina,
A. A., Meiler, J., … Kondrashov, F. (2022). Heterogeneity of the GFP fitness landscape
and data-driven protein design. ELife. eLife Sciences Publications. https://doi.org/10.7554/elife.75842
chicago: Gonzalez Somermeyer, Louisa, Aubin Fleiss, Alexander S Mishin, Nina G Bozhanova,
Anna A Igolkina, Jens Meiler, Maria-Elisenda Alaball Pujol, Ekaterina V Putintseva,
Karen S Sarkisyan, and Fyodor Kondrashov. “Heterogeneity of the GFP Fitness Landscape
and Data-Driven Protein Design.” ELife. eLife Sciences Publications, 2022.
https://doi.org/10.7554/elife.75842.
ieee: L. Gonzalez Somermeyer et al., “Heterogeneity of the GFP fitness landscape
and data-driven protein design,” eLife, vol. 11. eLife Sciences Publications,
2022.
ista: Gonzalez Somermeyer L, Fleiss A, Mishin AS, Bozhanova NG, Igolkina AA, Meiler
J, Alaball Pujol M-E, Putintseva EV, Sarkisyan KS, Kondrashov F. 2022. Heterogeneity
of the GFP fitness landscape and data-driven protein design. eLife. 11, 75842.
mla: Gonzalez Somermeyer, Louisa, et al. “Heterogeneity of the GFP Fitness Landscape
and Data-Driven Protein Design.” ELife, vol. 11, 75842, eLife Sciences
Publications, 2022, doi:10.7554/elife.75842.
short: L. Gonzalez Somermeyer, A. Fleiss, A.S. Mishin, N.G. Bozhanova, A.A. Igolkina,
J. Meiler, M.-E. Alaball Pujol, E.V. Putintseva, K.S. Sarkisyan, F. Kondrashov,
ELife 11 (2022).
date_created: 2022-06-18T09:06:59Z
date_published: 2022-05-05T00:00:00Z
date_updated: 2023-08-03T07:20:15Z
day: '05'
ddc:
- '570'
department:
- _id: GradSch
- _id: FyKo
doi: 10.7554/elife.75842
ec_funded: 1
external_id:
isi:
- '000799197200001'
file:
- access_level: open_access
checksum: 7573c28f44028ab0cc81faef30039e44
content_type: application/pdf
creator: dernst
date_created: 2022-06-20T07:44:19Z
date_updated: 2022-06-20T07:44:19Z
file_id: '11454'
file_name: 2022_eLife_Somermeyer.pdf
file_size: 5297213
relation: main_file
success: 1
file_date_updated: 2022-06-20T07:44:19Z
has_accepted_license: '1'
intvolume: ' 11'
isi: 1
keyword:
- General Immunology and Microbiology
- General Biochemistry
- Genetics and Molecular Biology
- General Medicine
- General Neuroscience
language:
- iso: eng
month: '05'
oa: 1
oa_version: Published Version
project:
- _id: 26580278-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '771209'
name: Characterizing the fitness landscape on population and global scales
- _id: 2564DBCA-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '665385'
name: International IST Doctoral Program
publication: eLife
publication_identifier:
issn:
- 2050-084X
publication_status: published
publisher: eLife Sciences Publications
quality_controlled: '1'
scopus_import: '1'
status: public
title: Heterogeneity of the GFP fitness landscape and data-driven protein design
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 11
year: '2022'
...
---
_id: '11449'
abstract:
- lang: eng
text: Mutations are acquired frequently, such that each cell's genome inscribes
its history of cell divisions. Common genomic alterations involve loss of heterozygosity
(LOH). LOH accumulates throughout the genome, offering large encoding capacity
for inferring cell lineage. Using only single-cell RNA sequencing (scRNA-seq)
of mouse brain cells, we found that LOH events spanning multiple genes are revealed
as tracts of monoallelically expressed, constitutionally heterozygous single-nucleotide
variants (SNVs). We simultaneously inferred cell lineage and marked developmental
time points based on X chromosome inactivation and the total number of LOH events
while identifying cell types from gene expression patterns. Our results are consistent
with progenitor cells giving rise to multiple cortical cell types through stereotyped
expansion and distinct waves of neurogenesis. This type of retrospective analysis
could be incorporated into scRNA-seq pipelines and, compared with experimental
approaches for determining lineage in model organisms, is applicable where genetic
engineering is prohibited, such as humans.
acknowledgement: D.J.A. thanks Wayne K. Potts, Alan R. Rogers, Kristen Hawkes, Ryk
Ward, and Jon Seger for inspiring a young undergraduate to apply evolutionary theory
to intraorganism development. Supported by the Paul G. Allen Frontiers Group (University
of Washington); NIH R00HG010152 (Dartmouth); and NÖ Forschung und Bildung n[f+b]
life science call grant (C13-002) and the European Research Council (ERC) under
the European Union’s Horizon 2020 research and innovation program 725780 LinPro
to S.H.
article_processing_charge: No
article_type: original
author:
- first_name: Donovan J.
full_name: Anderson, Donovan J.
last_name: Anderson
- first_name: Florian
full_name: Pauler, Florian
id: 48EA0138-F248-11E8-B48F-1D18A9856A87
last_name: Pauler
- first_name: Aaron
full_name: Mckenna, Aaron
last_name: Mckenna
- first_name: Jay
full_name: Shendure, Jay
last_name: Shendure
- first_name: Simon
full_name: Hippenmeyer, Simon
id: 37B36620-F248-11E8-B48F-1D18A9856A87
last_name: Hippenmeyer
orcid: 0000-0003-2279-1061
- first_name: Marshall S.
full_name: Horwitz, Marshall S.
last_name: Horwitz
citation:
ama: Anderson DJ, Pauler F, Mckenna A, Shendure J, Hippenmeyer S, Horwitz MS. Simultaneous
brain cell type and lineage determined by scRNA-seq reveals stereotyped cortical
development. Cell Systems. 2022;13(6):438-453.e5. doi:10.1016/j.cels.2022.03.006
apa: Anderson, D. J., Pauler, F., Mckenna, A., Shendure, J., Hippenmeyer, S., &
Horwitz, M. S. (2022). Simultaneous brain cell type and lineage determined by
scRNA-seq reveals stereotyped cortical development. Cell Systems. Elsevier.
https://doi.org/10.1016/j.cels.2022.03.006
chicago: Anderson, Donovan J., Florian Pauler, Aaron Mckenna, Jay Shendure, Simon
Hippenmeyer, and Marshall S. Horwitz. “Simultaneous Brain Cell Type and Lineage
Determined by ScRNA-Seq Reveals Stereotyped Cortical Development.” Cell Systems.
Elsevier, 2022. https://doi.org/10.1016/j.cels.2022.03.006.
ieee: D. J. Anderson, F. Pauler, A. Mckenna, J. Shendure, S. Hippenmeyer, and M.
S. Horwitz, “Simultaneous brain cell type and lineage determined by scRNA-seq
reveals stereotyped cortical development,” Cell Systems, vol. 13, no. 6.
Elsevier, p. 438–453.e5, 2022.
ista: Anderson DJ, Pauler F, Mckenna A, Shendure J, Hippenmeyer S, Horwitz MS. 2022.
Simultaneous brain cell type and lineage determined by scRNA-seq reveals stereotyped
cortical development. Cell Systems. 13(6), 438–453.e5.
mla: Anderson, Donovan J., et al. “Simultaneous Brain Cell Type and Lineage Determined
by ScRNA-Seq Reveals Stereotyped Cortical Development.” Cell Systems, vol.
13, no. 6, Elsevier, 2022, p. 438–453.e5, doi:10.1016/j.cels.2022.03.006.
short: D.J. Anderson, F. Pauler, A. Mckenna, J. Shendure, S. Hippenmeyer, M.S. Horwitz,
Cell Systems 13 (2022) 438–453.e5.
date_created: 2022-06-19T22:01:57Z
date_published: 2022-06-15T00:00:00Z
date_updated: 2023-08-03T07:19:43Z
day: '15'
department:
- _id: SiHi
doi: 10.1016/j.cels.2022.03.006
ec_funded: 1
external_id:
isi:
- '000814124400002'
pmid:
- '35452605'
intvolume: ' 13'
isi: 1
issue: '6'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://doi.org/10.1016/j.cels.2022.03.006
month: '06'
oa: 1
oa_version: Published Version
page: 438-453.e5
pmid: 1
project:
- _id: 260018B0-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '725780'
name: Principles of Neural Stem Cell Lineage Progression in Cerebral Cortex Development
- _id: 25D92700-B435-11E9-9278-68D0E5697425
grant_number: LS13-002
name: Mapping Cell-Type Specificity of the Genomic Imprintome in the Brain
publication: Cell Systems
publication_identifier:
eissn:
- 2405-4720
issn:
- 2405-4712
publication_status: published
publisher: Elsevier
quality_controlled: '1'
scopus_import: '1'
status: public
title: Simultaneous brain cell type and lineage determined by scRNA-seq reveals stereotyped
cortical development
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 13
year: '2022'
...
---
_id: '11451'
abstract:
- lang: eng
text: The precursor conversion chemistry and surface chemistry of Cu3N and Cu3PdN
nanocrystals are unknown or contested. Here, we first obtain phase-pure, colloidally
stable nanocubes. Second, we elucidate the pathway by which copper(II) nitrate
and oleylamine form Cu3N. We find that oleylamine is both a reductant and a nitrogen
source. Oleylamine is oxidized by nitrate to a primary aldimine, which reacts
further with excess oleylamine to a secondary aldimine, eliminating ammonia. Ammonia
reacts with CuI to form Cu3N. Third, we investigated the surface chemistry and
find a mixed ligand shell of aliphatic amines and carboxylates (formed in situ).
While the carboxylates appear tightly bound, the amines are easily desorbed from
the surface. Finally, we show that doping with palladium decreases the band gap
and the material becomes semi-metallic. These results bring insight into the chemistry
of metal nitrides and might help the development of other metal nitride nanocrystals.
acknowledgement: 'J.D.R. and M.P. acknowledge the SNF Eccellenza funding scheme (project
number: 194172). We acknowledge DESY (Hamburg, Germany), a member of the Helmholtz
Association HGF, for the provision of experimental facilities. Parts of this research
were carried out at beamline P21.1, PETRA III. We thank Dr. Soham Banerjee for acquiring
the PDF data and helpful advice. A.R. acknowledges the support from the Analytical
Chemistry Trust Fund for her CAMS-UK Fellowship. C.K. acknowledges the support from
the Department of Chemistry, UCL. The authors acknowledge Dr Stephan Lany from NREL
for providing the Cu3N DFT calculations. The authors thank Prof. Raymond Schaak
and Dr. Robert William Lord for helpful advice and suggestions regarding the purification
procedure. Open access funding provided by Universitat Basel.'
article_number: e202207013
article_processing_charge: No
article_type: original
author:
- first_name: Mahsa
full_name: Parvizian, Mahsa
last_name: Parvizian
- first_name: Alejandra
full_name: Duràn Balsa, Alejandra
last_name: Duràn Balsa
- first_name: Rohan
full_name: Pokratath, Rohan
last_name: Pokratath
- first_name: Curran
full_name: Kalha, Curran
last_name: Kalha
- first_name: Seungho
full_name: Lee, Seungho
id: BB243B88-D767-11E9-B658-BC13E6697425
last_name: Lee
orcid: 0000-0002-6962-8598
- first_name: Dietger
full_name: Van Den Eynden, Dietger
last_name: Van Den Eynden
- first_name: Maria
full_name: Ibáñez, Maria
id: 43C61214-F248-11E8-B48F-1D18A9856A87
last_name: Ibáñez
orcid: 0000-0001-5013-2843
- first_name: Anna
full_name: Regoutz, Anna
last_name: Regoutz
- first_name: Jonathan
full_name: De Roo, Jonathan
last_name: De Roo
citation:
ama: Parvizian M, Duràn Balsa A, Pokratath R, et al. The chemistry of Cu₃N and Cu₃PdN
nanocrystals. Angewandte Chemie - International Edition. 2022;61(31). doi:10.1002/anie.202207013
apa: Parvizian, M., Duràn Balsa, A., Pokratath, R., Kalha, C., Lee, S., Van Den
Eynden, D., … De Roo, J. (2022). The chemistry of Cu₃N and Cu₃PdN nanocrystals.
Angewandte Chemie - International Edition. Wiley. https://doi.org/10.1002/anie.202207013
chicago: Parvizian, Mahsa, Alejandra Duràn Balsa, Rohan Pokratath, Curran Kalha,
Seungho Lee, Dietger Van Den Eynden, Maria Ibáñez, Anna Regoutz, and Jonathan
De Roo. “The Chemistry of Cu₃N and Cu₃PdN Nanocrystals.” Angewandte Chemie
- International Edition. Wiley, 2022. https://doi.org/10.1002/anie.202207013.
ieee: M. Parvizian et al., “The chemistry of Cu₃N and Cu₃PdN nanocrystals,”
Angewandte Chemie - International Edition, vol. 61, no. 31. Wiley, 2022.
ista: Parvizian M, Duràn Balsa A, Pokratath R, Kalha C, Lee S, Van Den Eynden D,
Ibáñez M, Regoutz A, De Roo J. 2022. The chemistry of Cu₃N and Cu₃PdN nanocrystals.
Angewandte Chemie - International Edition. 61(31), e202207013.
mla: Parvizian, Mahsa, et al. “The Chemistry of Cu₃N and Cu₃PdN Nanocrystals.” Angewandte
Chemie - International Edition, vol. 61, no. 31, e202207013, Wiley, 2022,
doi:10.1002/anie.202207013.
short: M. Parvizian, A. Duràn Balsa, R. Pokratath, C. Kalha, S. Lee, D. Van Den
Eynden, M. Ibáñez, A. Regoutz, J. De Roo, Angewandte Chemie - International Edition
61 (2022).
date_created: 2022-06-19T22:01:58Z
date_published: 2022-08-01T00:00:00Z
date_updated: 2023-08-03T07:19:12Z
day: '01'
ddc:
- '540'
department:
- _id: MaIb
doi: 10.1002/anie.202207013
external_id:
isi:
- '000811084000001'
pmid:
- '35612297'
file:
- access_level: open_access
checksum: 2a3ee0bb59e044b808ebe85cd94ac899
content_type: application/pdf
creator: dernst
date_created: 2022-07-29T09:29:20Z
date_updated: 2022-07-29T09:29:20Z
file_id: '11696'
file_name: 2022_AngewandteChemieInternat_Parvizian.pdf
file_size: 1303202
relation: main_file
success: 1
file_date_updated: 2022-07-29T09:29:20Z
has_accepted_license: '1'
intvolume: ' 61'
isi: 1
issue: '31'
language:
- iso: eng
month: '08'
oa: 1
oa_version: Published Version
pmid: 1
publication: Angewandte Chemie - International Edition
publication_identifier:
eissn:
- 1521-3773
issn:
- 1433-7851
publication_status: published
publisher: Wiley
quality_controlled: '1'
related_material:
record:
- id: '11695'
relation: research_data
status: public
scopus_import: '1'
status: public
title: The chemistry of Cu₃N and Cu₃PdN nanocrystals
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 61
year: '2022'
...
---
_id: '11456'
abstract:
- lang: eng
text: The proteomes of specialized structures, and the interactomes of proteins
of interest, provide entry points to elucidate the functions of molecular machines.
Here, we review a proximity-labeling strategy that uses the improved E. coli biotin
ligase TurboID to characterize C. elegans protein complexes. Although the focus
is on C. elegans neurons, the method is applicable regardless of cell type. We
describe detailed extraction procedures that solubilize the bulk of C. elegans
proteins and highlight the importance of tagging endogenous genes, to ensure physiological
expression levels. We review issues associated with non-specific background noise
and the importance of appropriate controls. As proof of principle, we review our
analysis of the interactome of a presynaptic active zone protein, ELKS-1. Our
aim is to provide a detailed protocol for TurboID-based proximity labeling in
C. elegans and to highlight its potential and its limitations to characterize
protein complexes and subcellular compartments in this animal.
acknowledgement: We thank de Bono lab members for the helpful comments on the manuscript.
The biotin-auxotrophic E. coli strain MG1655bioB:kan was a generous gift from J.
Cronan (University of Illinois) and was kindly sent to us by Jessica Feldman and
Ariana Sanchez (Stanford University). dg398 pEntryslot2_mNeongreen::3XFLAG::stop
and dg397 pEntryslot3_mNeongreen::3XFLAG::stop::unc-54 3’UTR entry vector were kindly
sent by Dr. Dominique Glauser (University of Fribourg). This work was supported
by an Advanced ERC Grant (269058 ACMO) and a Wellcome Investigator Award (209504/Z/17/Z)
to MdB and an ISTplus Fellowship to MA (Marie Sklodowska-Curie agreement No 754411).
alternative_title:
- Neuromethods
article_processing_charge: No
author:
- first_name: Murat
full_name: Artan, Murat
id: C407B586-6052-11E9-B3AE-7006E6697425
last_name: Artan
- first_name: Mario
full_name: de Bono, Mario
id: 4E3FF80E-F248-11E8-B48F-1D18A9856A87
last_name: de Bono
orcid: 0000-0001-8347-0443
citation:
ama: 'Artan M, de Bono M. Proteomic Analysis of C. Elegans Neurons Using TurboID-Based
Proximity Labeling. In: Yamamoto D, ed. Behavioral Neurogenetics. Vol 181.
NM. New York: Springer Nature; 2022:277-294. doi:10.1007/978-1-0716-2321-3_15'
apa: 'Artan, M., & de Bono, M. (2022). Proteomic Analysis of C. Elegans Neurons
Using TurboID-Based Proximity Labeling. In D. Yamamoto (Ed.), Behavioral Neurogenetics
(Vol. 181, pp. 277–294). New York: Springer Nature. https://doi.org/10.1007/978-1-0716-2321-3_15'
chicago: 'Artan, Murat, and Mario de Bono. “Proteomic Analysis of C. Elegans Neurons
Using TurboID-Based Proximity Labeling.” In Behavioral Neurogenetics, edited
by Daisuke Yamamoto, 181:277–94. NM. New York: Springer Nature, 2022. https://doi.org/10.1007/978-1-0716-2321-3_15.'
ieee: 'M. Artan and M. de Bono, “Proteomic Analysis of C. Elegans Neurons Using
TurboID-Based Proximity Labeling,” in Behavioral Neurogenetics, vol. 181,
D. Yamamoto, Ed. New York: Springer Nature, 2022, pp. 277–294.'
ista: 'Artan M, de Bono M. 2022.Proteomic Analysis of C. Elegans Neurons Using TurboID-Based
Proximity Labeling. In: Behavioral Neurogenetics. Neuromethods, vol. 181, 277–294.'
mla: Artan, Murat, and Mario de Bono. “Proteomic Analysis of C. Elegans Neurons
Using TurboID-Based Proximity Labeling.” Behavioral Neurogenetics, edited
by Daisuke Yamamoto, vol. 181, Springer Nature, 2022, pp. 277–94, doi:10.1007/978-1-0716-2321-3_15.
short: M. Artan, M. de Bono, in:, D. Yamamoto (Ed.), Behavioral Neurogenetics, Springer
Nature, New York, 2022, pp. 277–294.
date_created: 2022-06-20T08:10:34Z
date_published: 2022-06-04T00:00:00Z
date_updated: 2023-02-21T09:51:55Z
day: '04'
department:
- _id: MaDe
doi: 10.1007/978-1-0716-2321-3_15
ec_funded: 1
editor:
- first_name: Daisuke
full_name: Yamamoto, Daisuke
last_name: Yamamoto
intvolume: ' 181'
language:
- iso: eng
month: '06'
oa_version: None
page: 277-294
place: New York
project:
- _id: 23870BE8-32DE-11EA-91FC-C7463DDC885E
grant_number: 209504/A/17/Z
name: Molecular mechanisms of neural circuit function
- _id: 260C2330-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '754411'
name: ISTplus - Postdoctoral Fellowships
publication: Behavioral Neurogenetics
publication_identifier:
eisbn:
- '9781071623213'
eissn:
- 1940-6045
isbn:
- '9781071623206'
issn:
- 0893-2336
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
scopus_import: '1'
series_title: NM
status: public
title: Proteomic Analysis of C. Elegans Neurons Using TurboID-Based Proximity Labeling
type: book_chapter
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 181
year: '2022'
...
---
_id: '11459'
abstract:
- lang: eng
text: 'We present a novel approach to differential cost analysis that, given a program
revision, attempts to statically bound the difference in resource usage, or cost,
between the two program versions. Differential cost analysis is particularly interesting
because of the many compelling applications for it, such as detecting resource-use
regressions at code-review time or proving the absence of certain side-channel
vulnerabilities. One prior approach to differential cost analysis is to apply
relational reasoning that conceptually constructs a product program on which one
can over-approximate the difference in costs between the two program versions.
However, a significant challenge in any relational approach is effectively aligning
the program versions to get precise results. In this paper, our key insight is
that we can avoid the need for and the limitations of program alignment if, instead,
we bound the difference of two cost-bound summaries rather than directly bounding
the concrete cost difference. In particular, our method computes a threshold value
for the maximal difference in cost between two program versions simultaneously
using two kinds of cost-bound summaries---a potential function that evaluates
to an upper bound for the cost incurred in the first program and an anti-potential
function that evaluates to a lower bound for the cost incurred in the second.
Our method has a number of desirable properties: it can be fully automated, it
allows optimizing the threshold value on relative cost, it is suitable for programs
that are not syntactically similar, and it supports non-determinism. We have evaluated
an implementation of our approach on a number of program pairs collected from
the literature, and we find that our method computes tight threshold values on
relative cost in most examples.'
acknowledgement: "We thank Shaun Willows, Thomas Lugnet, and the Living Room Application
Vending team for suggesting threshold\r\nbounds as a developer-friendly way to interact
with a differential cost analyzer, and we thank Jim Christy, Daniel\r\nSchoepe,
and the Prime Video Automated Reasoning team for their support and helpful suggestions
throughout the\r\nproject. We also thank Michael Emmi for feedback on an earlier
version of this paper. And finally, we thank the anonymous reviewers for their useful
feedback and Aws Albarghouthi for shepherding the final version of the paper. Ðorđe
Žikelić was also partially supported by ERC CoG 863818 (FoRM-SMArt)."
article_processing_charge: No
arxiv: 1
author:
- first_name: Dorde
full_name: Zikelic, Dorde
id: 294AA7A6-F248-11E8-B48F-1D18A9856A87
last_name: Zikelic
orcid: 0000-0002-4681-1699
- first_name: Bor-Yuh Evan
full_name: Chang, Bor-Yuh Evan
last_name: Chang
- first_name: Pauline
full_name: Bolignano, Pauline
last_name: Bolignano
- first_name: Franco
full_name: Raimondi, Franco
last_name: Raimondi
citation:
ama: 'Zikelic D, Chang B-YE, Bolignano P, Raimondi F. Differential cost analysis
with simultaneous potentials and anti-potentials. In: Proceedings of the 43rd
ACM SIGPLAN International Conference on Programming Language Design and Implementation.
Association for Computing Machinery; 2022:442-457. doi:10.1145/3519939.3523435'
apa: 'Zikelic, D., Chang, B.-Y. E., Bolignano, P., & Raimondi, F. (2022). Differential
cost analysis with simultaneous potentials and anti-potentials. In Proceedings
of the 43rd ACM SIGPLAN International Conference on Programming Language Design
and Implementation (pp. 442–457). San Diego, CA, United States: Association
for Computing Machinery. https://doi.org/10.1145/3519939.3523435'
chicago: Zikelic, Dorde, Bor-Yuh Evan Chang, Pauline Bolignano, and Franco Raimondi.
“Differential Cost Analysis with Simultaneous Potentials and Anti-Potentials.”
In Proceedings of the 43rd ACM SIGPLAN International Conference on Programming
Language Design and Implementation, 442–57. Association for Computing Machinery,
2022. https://doi.org/10.1145/3519939.3523435.
ieee: D. Zikelic, B.-Y. E. Chang, P. Bolignano, and F. Raimondi, “Differential cost
analysis with simultaneous potentials and anti-potentials,” in Proceedings
of the 43rd ACM SIGPLAN International Conference on Programming Language Design
and Implementation, San Diego, CA, United States, 2022, pp. 442–457.
ista: 'Zikelic D, Chang B-YE, Bolignano P, Raimondi F. 2022. Differential cost analysis
with simultaneous potentials and anti-potentials. Proceedings of the 43rd ACM
SIGPLAN International Conference on Programming Language Design and Implementation.
PLDI: Programming Language Design and Implementation, 442–457.'
mla: Zikelic, Dorde, et al. “Differential Cost Analysis with Simultaneous Potentials
and Anti-Potentials.” Proceedings of the 43rd ACM SIGPLAN International Conference
on Programming Language Design and Implementation, Association for Computing
Machinery, 2022, pp. 442–57, doi:10.1145/3519939.3523435.
short: D. Zikelic, B.-Y.E. Chang, P. Bolignano, F. Raimondi, in:, Proceedings of
the 43rd ACM SIGPLAN International Conference on Programming Language Design and
Implementation, Association for Computing Machinery, 2022, pp. 442–457.
conference:
end_date: 2022-06-17
location: San Diego, CA, United States
name: 'PLDI: Programming Language Design and Implementation'
start_date: 2022-06-13
date_created: 2022-06-21T09:26:15Z
date_published: 2022-06-09T00:00:00Z
date_updated: 2025-07-14T09:09:54Z
day: '09'
ddc:
- '000'
department:
- _id: GradSch
- _id: KrCh
doi: 10.1145/3519939.3523435
ec_funded: 1
external_id:
arxiv:
- '2204.00870'
isi:
- '000850435600030'
file:
- access_level: open_access
checksum: 7eb915a2ca5b5ce4729321f33b2e16e1
content_type: application/pdf
creator: dernst
date_created: 2022-06-27T07:38:21Z
date_updated: 2022-06-27T07:38:21Z
file_id: '11466'
file_name: 2022_PLDI_Zikelic.pdf
file_size: 318697
relation: main_file
success: 1
file_date_updated: 2022-06-27T07:38:21Z
has_accepted_license: '1'
isi: 1
language:
- iso: eng
month: '06'
oa: 1
oa_version: Published Version
page: 442-457
project:
- _id: 0599E47C-7A3F-11EA-A408-12923DDC885E
call_identifier: H2020
grant_number: '863818'
name: 'Formal Methods for Stochastic Models: Algorithms and Applications'
publication: Proceedings of the 43rd ACM SIGPLAN International Conference on Programming
Language Design and Implementation
publication_identifier:
isbn:
- '9781450392655'
publication_status: published
publisher: Association for Computing Machinery
quality_controlled: '1'
scopus_import: '1'
status: public
title: Differential cost analysis with simultaneous potentials and anti-potentials
tmp:
image: /images/cc_by_nc_nd.png
legal_code_url: https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode
name: Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
(CC BY-NC-ND 4.0)
short: CC BY-NC-ND (4.0)
type: conference
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
year: '2022'
...
---
_id: '11460'
abstract:
- lang: eng
text: "Background: Proper cerebral cortical development depends on the tightly orchestrated
migration of newly born neurons from the inner ventricular and subventricular
zones to the outer cortical plate. Any disturbance in this process during prenatal
stages may lead to neuronal migration disorders (NMDs), which can vary in extent
from focal to global. Furthermore, NMDs show a substantial comorbidity with other
neurodevelopmental disorders, notably autism spectrum disorders (ASDs). Our previous
work demonstrated focal neuronal migration defects in mice carrying loss-of-function
alleles of the recognized autism risk gene WDFY3. However, the cellular origins
of these defects in Wdfy3 mutant mice remain elusive and uncovering it will provide
critical insight into WDFY3-dependent disease pathology.\r\nMethods: Here, in
an effort to untangle the origins of NMDs in Wdfy3lacZ mice, we employed mosaic
analysis with double markers (MADM). MADM technology enabled us to genetically
distinctly track and phenotypically analyze mutant and wild-type cells concomitantly
in vivo using immunofluorescent techniques.\r\nResults: We revealed a cell autonomous
requirement of WDFY3 for accurate laminar positioning of cortical projection neurons
and elimination of mispositioned cells during early postnatal life. In addition,
we identified significant deviations in dendritic arborization, as well as synaptic
density and morphology between wild type, heterozygous, and homozygous Wdfy3 mutant
neurons in Wdfy3-MADM reporter mice at postnatal stages.\r\nLimitations: While
Wdfy3 mutant mice have provided valuable insight into prenatal aspects of ASD
pathology that remain inaccessible to investigation in humans, like most animal
models, they do not a perfectly replicate all aspects of human ASD biology. The
lack of human data makes it indeterminate whether morphological deviations described
here apply to ASD patients or some of the other neurodevelopmental conditions
associated with WDFY3 mutation.\r\nConclusions: Our genetic approach revealed
several cell autonomous requirements of WDFY3 in neuronal development that could
underlie the pathogenic mechanisms of WDFY3-related neurodevelopmental conditions.
The results are also consistent with findings in other ASD animal models and patients
and suggest an important role for WDFY3 in regulating neuronal function and interconnectivity
in postnatal life."
acknowledgement: "This study was funded by NIMH R21MH115347 to KSZ. KSZ is further
supported by Shriners Hospitals for Children.\r\nWe would like to thank Angelo Harlan
de Crescenzo for early contributions to this project."
article_number: '27'
article_processing_charge: No
article_type: original
author:
- first_name: Zachary A.
full_name: Schaaf, Zachary A.
last_name: Schaaf
- first_name: Lyvin
full_name: Tat, Lyvin
last_name: Tat
- first_name: Noemi
full_name: Cannizzaro, Noemi
last_name: Cannizzaro
- first_name: Ralph
full_name: Green, Ralph
last_name: Green
- first_name: Thomas
full_name: Rülicke, Thomas
last_name: Rülicke
- first_name: Simon
full_name: Hippenmeyer, Simon
id: 37B36620-F248-11E8-B48F-1D18A9856A87
last_name: Hippenmeyer
orcid: 0000-0003-2279-1061
- first_name: Konstantinos S.
full_name: Zarbalis, Konstantinos S.
last_name: Zarbalis
citation:
ama: Schaaf ZA, Tat L, Cannizzaro N, et al. WDFY3 mutation alters laminar position
and morphology of cortical neurons. Molecular Autism. 2022;13. doi:10.1186/s13229-022-00508-3
apa: Schaaf, Z. A., Tat, L., Cannizzaro, N., Green, R., Rülicke, T., Hippenmeyer,
S., & Zarbalis, K. S. (2022). WDFY3 mutation alters laminar position and morphology
of cortical neurons. Molecular Autism. Springer Nature. https://doi.org/10.1186/s13229-022-00508-3
chicago: Schaaf, Zachary A., Lyvin Tat, Noemi Cannizzaro, Ralph Green, Thomas Rülicke,
Simon Hippenmeyer, and Konstantinos S. Zarbalis. “WDFY3 Mutation Alters Laminar
Position and Morphology of Cortical Neurons.” Molecular Autism. Springer
Nature, 2022. https://doi.org/10.1186/s13229-022-00508-3.
ieee: Z. A. Schaaf et al., “WDFY3 mutation alters laminar position and morphology
of cortical neurons,” Molecular Autism, vol. 13. Springer Nature, 2022.
ista: Schaaf ZA, Tat L, Cannizzaro N, Green R, Rülicke T, Hippenmeyer S, Zarbalis
KS. 2022. WDFY3 mutation alters laminar position and morphology of cortical neurons.
Molecular Autism. 13, 27.
mla: Schaaf, Zachary A., et al. “WDFY3 Mutation Alters Laminar Position and Morphology
of Cortical Neurons.” Molecular Autism, vol. 13, 27, Springer Nature, 2022,
doi:10.1186/s13229-022-00508-3.
short: Z.A. Schaaf, L. Tat, N. Cannizzaro, R. Green, T. Rülicke, S. Hippenmeyer,
K.S. Zarbalis, Molecular Autism 13 (2022).
date_created: 2022-06-23T14:28:55Z
date_published: 2022-06-22T00:00:00Z
date_updated: 2023-08-03T07:21:32Z
day: '22'
ddc:
- '570'
department:
- _id: SiHi
doi: 10.1186/s13229-022-00508-3
external_id:
isi:
- '000814641400001'
file:
- access_level: open_access
checksum: 525d2618e855139089bbfc3e3d49d1b2
content_type: application/pdf
creator: dernst
date_created: 2022-06-24T08:22:59Z
date_updated: 2022-06-24T08:22:59Z
file_id: '11461'
file_name: 2022_MolecularAutism_Schaaf.pdf
file_size: 7552298
relation: main_file
success: 1
file_date_updated: 2022-06-24T08:22:59Z
has_accepted_license: '1'
intvolume: ' 13'
isi: 1
keyword:
- Psychiatry and Mental health
- Developmental Biology
- Developmental Neuroscience
- Molecular Biology
language:
- iso: eng
month: '06'
oa: 1
oa_version: Published Version
publication: Molecular Autism
publication_identifier:
issn:
- 2040-2392
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
related_material:
link:
- relation: erratum
url: https://doi.org/10.1186/s13229-023-00539-4
status: public
title: WDFY3 mutation alters laminar position and morphology of cortical neurons
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 13
year: '2022'
...
---
_id: '11462'
abstract:
- lang: eng
text: Nanobodies (VHH) from camelid antibody libraries hold great promise as therapeutic
agents and components of immunoassay systems. Synthetic antibody libraries that
could be designed and generated once and for various applications could yield
binders to virtually any targets, even for non-immunogenic or toxic ones, in a
short term. One of the most difficult tasks is to obtain antibodies with a high
affinity and specificity to polyglycosylated proteins. It requires antibody libraries
with extremely high functional diversity and the use of sophisticated selection
techniques. Here we report a development of a novel sandwich immunoassay involving
a combination of the synthetic library-derived VHH-Fc fusion protein as a capture
antibody and the immune single-chain fragment variable (scFv) as a tracer for
the detection of pregnancy-associated glycoprotein (PAG) of cattle (Bos taurus).
We succeeded in the generation of a number of specific scFv antibodies against
PAG from the mouse immune library. Subsequent selection using the immobilized
scFv-Fc capture antibody allowed to isolate 1.9 nM VHH binder from the diverse
synthetic library without any overlapping with the capture antibody binding site.
The prototype sandwich ELISA based on the synthetic VHH and the immune scFv was
established. This is the first successful example of the combination of synthetic
and immune antibody libraries in a single sandwich immunoassay. Thus, our approach
could be used for the express isolation of antibody pairs and the development
of sandwich immunoassays for challenging antigens.
acknowledgement: This study was financially supported by the State Committee on Science
and Technology. We would like to thank Elena Tumar and Elena Kisileva at the Institute
of Bioorganic Chemistry of NASB for their kind assistance with mouse immunizations.
article_processing_charge: No
article_type: original
author:
- first_name: Dmitri
full_name: Dormeshkin, Dmitri
last_name: Dormeshkin
- first_name: Michail
full_name: Shapira, Michail
last_name: Shapira
- first_name: Alena
full_name: Karputs, Alena
last_name: Karputs
- first_name: Anton
full_name: Kavaleuski, Anton
id: 62304f89-eb97-11eb-a6c2-8903dd183976
last_name: Kavaleuski
orcid: 0000-0003-2091-526X
- first_name: Ivan
full_name: Kuzminski, Ivan
last_name: Kuzminski
- first_name: Elena
full_name: Stepanova, Elena
last_name: Stepanova
- first_name: Andrei
full_name: Gilep, Andrei
last_name: Gilep
citation:
ama: Dormeshkin D, Shapira M, Karputs A, et al. Combining of synthetic VHH and immune
scFv libraries for pregnancy-associated glycoproteins ELISA development. Applied
Microbiology and Biotechnology. 2022;106:5093-5103. doi:10.1007/s00253-022-12022-w
apa: Dormeshkin, D., Shapira, M., Karputs, A., Kavaleuski, A., Kuzminski, I., Stepanova,
E., & Gilep, A. (2022). Combining of synthetic VHH and immune scFv libraries
for pregnancy-associated glycoproteins ELISA development. Applied Microbiology
and Biotechnology. Springer Nature. https://doi.org/10.1007/s00253-022-12022-w
chicago: Dormeshkin, Dmitri, Michail Shapira, Alena Karputs, Anton Kavaleuski, Ivan
Kuzminski, Elena Stepanova, and Andrei Gilep. “Combining of Synthetic VHH and
Immune ScFv Libraries for Pregnancy-Associated Glycoproteins ELISA Development.”
Applied Microbiology and Biotechnology. Springer Nature, 2022. https://doi.org/10.1007/s00253-022-12022-w.
ieee: D. Dormeshkin et al., “Combining of synthetic VHH and immune scFv libraries
for pregnancy-associated glycoproteins ELISA development,” Applied Microbiology
and Biotechnology, vol. 106. Springer Nature, pp. 5093–5103, 2022.
ista: Dormeshkin D, Shapira M, Karputs A, Kavaleuski A, Kuzminski I, Stepanova E,
Gilep A. 2022. Combining of synthetic VHH and immune scFv libraries for pregnancy-associated
glycoproteins ELISA development. Applied Microbiology and Biotechnology. 106,
5093–5103.
mla: Dormeshkin, Dmitri, et al. “Combining of Synthetic VHH and Immune ScFv Libraries
for Pregnancy-Associated Glycoproteins ELISA Development.” Applied Microbiology
and Biotechnology, vol. 106, Springer Nature, 2022, pp. 5093–103, doi:10.1007/s00253-022-12022-w.
short: D. Dormeshkin, M. Shapira, A. Karputs, A. Kavaleuski, I. Kuzminski, E. Stepanova,
A. Gilep, Applied Microbiology and Biotechnology 106 (2022) 5093–5103.
date_created: 2022-06-26T22:01:34Z
date_published: 2022-08-01T00:00:00Z
date_updated: 2023-10-10T07:15:02Z
day: '01'
department:
- _id: GradSch
- _id: LeSa
doi: 10.1007/s00253-022-12022-w
external_id:
isi:
- '000813677500001'
pmid:
- '35723693'
intvolume: ' 106'
isi: 1
language:
- iso: eng
month: '08'
oa_version: None
page: 5093-5103
pmid: 1
publication: Applied Microbiology and Biotechnology
publication_identifier:
eissn:
- 1432-0614
issn:
- 0175-7598
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
scopus_import: '1'
status: public
title: Combining of synthetic VHH and immune scFv libraries for pregnancy-associated
glycoproteins ELISA development
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 106
year: '2022'
...
---
_id: '11469'
abstract:
- lang: eng
text: Thermalizing and localized many-body quantum systems present two distinct
dynamical phases of matter. Recently the fate of a localized system coupled to
a thermalizing system viewed as a quantum bath received significant theoretical
and experimental attention. In this work, we study a mobile impurity, representing
a small quantum bath, that interacts locally with an Anderson insulator with a
finite density of localized particles. Using static Hartree approximation to obtain
an effective disorder strength, we formulate an analytic criterion for the perturbative
stability of the localization. Next, we use an approximate dynamical Hartree method
and the quasi-exact time-evolved block decimation (TEBD) algorithm to study the
dynamics of the system. We find that the dynamical Hartree approach which completely
ignores entanglement between the impurity and localized particles predicts the
delocalization of the system. In contrast, the full numerical simulation of the
unitary dynamics with TEBD suggests the stability of localization on numerically
accessible timescales. Finally, using an extension of the density matrix renormalization
group algorithm to excited states (DMRG-X), we approximate the highly excited
eigenstates of the system. We find that the impurity remains localized in the
eigenstates and entanglement is enhanced in a finite region around the position
of the impurity, confirming the dynamical predictions. Dynamics and the DMRG-X
results provide compelling evidence for the stability of localization.
acknowledged_ssus:
- _id: ScienComp
acknowledgement: We thank M. Ljubotina for insightful discussions. P. B., A. M. and
M. S. acknowledge support by the European Research Council (ERC) under the European
Union’s Horizon 2020 research and innovation program (Grant Agreement No. 850899).
D. A. was supported by the Swiss National Science Foundation and by the European
Research Council (ERC) under the European Union’s Horizon 2020 research and innovation
program (Grant Agreement No. 864597). The development of parallel TEBD code was
supported by S. Elefante from the Scientific Computing (SciComp) that is part of
Scientific Service Units (SSU) of IST Austria. Some of the computations were performed
on the Baobab cluster of the University of Geneva.
article_number: '224208'
article_processing_charge: No
article_type: original
arxiv: 1
author:
- first_name: Pietro
full_name: Brighi, Pietro
id: 4115AF5C-F248-11E8-B48F-1D18A9856A87
last_name: Brighi
orcid: 0000-0002-7969-2729
- first_name: Alexios
full_name: Michailidis, Alexios
id: 36EBAD38-F248-11E8-B48F-1D18A9856A87
last_name: Michailidis
orcid: 0000-0002-8443-1064
- first_name: Kristina
full_name: Kirova, Kristina
id: 4aeda2ae-f847-11ec-98e0-c4a66fe174d4
last_name: Kirova
- first_name: Dmitry A.
full_name: Abanin, Dmitry A.
last_name: Abanin
- first_name: Maksym
full_name: Serbyn, Maksym
id: 47809E7E-F248-11E8-B48F-1D18A9856A87
last_name: Serbyn
orcid: 0000-0002-2399-5827
citation:
ama: Brighi P, Michailidis A, Kirova K, Abanin DA, Serbyn M. Localization of a mobile
impurity interacting with an Anderson insulator. Physical Review B. 2022;105(22).
doi:10.1103/physrevb.105.224208
apa: Brighi, P., Michailidis, A., Kirova, K., Abanin, D. A., & Serbyn, M. (2022).
Localization of a mobile impurity interacting with an Anderson insulator. Physical
Review B. American Physical Society. https://doi.org/10.1103/physrevb.105.224208
chicago: Brighi, Pietro, Alexios Michailidis, Kristina Kirova, Dmitry A. Abanin,
and Maksym Serbyn. “Localization of a Mobile Impurity Interacting with an Anderson
Insulator.” Physical Review B. American Physical Society, 2022. https://doi.org/10.1103/physrevb.105.224208.
ieee: P. Brighi, A. Michailidis, K. Kirova, D. A. Abanin, and M. Serbyn, “Localization
of a mobile impurity interacting with an Anderson insulator,” Physical Review
B, vol. 105, no. 22. American Physical Society, 2022.
ista: Brighi P, Michailidis A, Kirova K, Abanin DA, Serbyn M. 2022. Localization
of a mobile impurity interacting with an Anderson insulator. Physical Review B.
105(22), 224208.
mla: Brighi, Pietro, et al. “Localization of a Mobile Impurity Interacting with
an Anderson Insulator.” Physical Review B, vol. 105, no. 22, 224208, American
Physical Society, 2022, doi:10.1103/physrevb.105.224208.
short: P. Brighi, A. Michailidis, K. Kirova, D.A. Abanin, M. Serbyn, Physical Review
B 105 (2022).
date_created: 2022-06-29T20:19:51Z
date_published: 2022-06-27T00:00:00Z
date_updated: 2023-09-05T12:12:52Z
day: '27'
department:
- _id: MaSe
doi: 10.1103/physrevb.105.224208
ec_funded: 1
external_id:
arxiv:
- '2111.08603'
isi:
- '000823050000001'
intvolume: ' 105'
isi: 1
issue: '22'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: ' https://doi.org/10.48550/arXiv.2111.08603 Focus to learn more'
month: '06'
oa: 1
oa_version: Preprint
project:
- _id: 23841C26-32DE-11EA-91FC-C7463DDC885E
call_identifier: H2020
grant_number: '850899'
name: 'Non-Ergodic Quantum Matter: Universality, Dynamics and Control'
publication: Physical Review B
publication_identifier:
eissn:
- 2469-9969
issn:
- 2469-9950
publication_status: published
publisher: American Physical Society
quality_controlled: '1'
related_material:
record:
- id: '12732'
relation: dissertation_contains
status: public
status: public
title: Localization of a mobile impurity interacting with an Anderson insulator
type: journal_article
user_id: c635000d-4b10-11ee-a964-aac5a93f6ac1
volume: 105
year: '2022'
...
---
_id: '11470'
abstract:
- lang: eng
text: Many-body localization (MBL) is an example of a dynamical phase of matter
that avoids thermalization. While the MBL phase is robust to weak local perturbations,
the fate of an MBL system coupled to a thermalizing quantum system that represents
a “heat bath” is an open question that is actively investigated theoretically
and experimentally. In this work, we consider the stability of an Anderson insulator
with a finite density of particles interacting with a single mobile impurity—a
small quantum bath. We give perturbative arguments that support the stability
of localization in the strong interaction regime. Large-scale tensor network simulations
of dynamics are employed to corroborate the presence of the localized phase and
give quantitative predictions in the thermodynamic limit. We develop a phenomenological
description of the dynamics in the strong interaction regime, and we demonstrate
that the impurity effectively turns the Anderson insulator into an MBL phase,
giving rise to nontrivial entanglement dynamics well captured by our phenomenology.
acknowledged_ssus:
- _id: ScienComp
acknowledgement: We acknowledge useful discussions with M. Ljubotina. P. B., A. M.,
and M. S. were supported by the European Research Council (ERC) under the European
Union’s Horizon 2020 research and innovation program (Grant Agreement No. 850899).
D.A. was supported by the Swiss National Science Foundation and by the European
Research Council (ERC) under the European Union’s Horizon 2020 research and innovation
program (Grant Agreement No. 864597). The development of parallel TEBD code was
was supported by S. Elefante from the Scientific Computing (SciComp) that is part
of Scientific Service Units (SSU) of IST Austria. Some of the computations were
performed on the Baobab cluster of the University of Geneva.
article_number: L220203
article_processing_charge: No
article_type: original
arxiv: 1
author:
- first_name: Pietro
full_name: Brighi, Pietro
id: 4115AF5C-F248-11E8-B48F-1D18A9856A87
last_name: Brighi
orcid: 0000-0002-7969-2729
- first_name: Alexios A.
full_name: Michailidis, Alexios A.
last_name: Michailidis
- first_name: Dmitry A.
full_name: Abanin, Dmitry A.
last_name: Abanin
- first_name: Maksym
full_name: Serbyn, Maksym
id: 47809E7E-F248-11E8-B48F-1D18A9856A87
last_name: Serbyn
orcid: 0000-0002-2399-5827
citation:
ama: Brighi P, Michailidis AA, Abanin DA, Serbyn M. Propagation of many-body localization
in an Anderson insulator. Physical Review B. 2022;105(22). doi:10.1103/physrevb.105.l220203
apa: Brighi, P., Michailidis, A. A., Abanin, D. A., & Serbyn, M. (2022). Propagation
of many-body localization in an Anderson insulator. Physical Review B.
American Physical Society. https://doi.org/10.1103/physrevb.105.l220203
chicago: Brighi, Pietro, Alexios A. Michailidis, Dmitry A. Abanin, and Maksym Serbyn.
“Propagation of Many-Body Localization in an Anderson Insulator.” Physical
Review B. American Physical Society, 2022. https://doi.org/10.1103/physrevb.105.l220203.
ieee: P. Brighi, A. A. Michailidis, D. A. Abanin, and M. Serbyn, “Propagation of
many-body localization in an Anderson insulator,” Physical Review B, vol.
105, no. 22. American Physical Society, 2022.
ista: Brighi P, Michailidis AA, Abanin DA, Serbyn M. 2022. Propagation of many-body
localization in an Anderson insulator. Physical Review B. 105(22), L220203.
mla: Brighi, Pietro, et al. “Propagation of Many-Body Localization in an Anderson
Insulator.” Physical Review B, vol. 105, no. 22, L220203, American Physical
Society, 2022, doi:10.1103/physrevb.105.l220203.
short: P. Brighi, A.A. Michailidis, D.A. Abanin, M. Serbyn, Physical Review B 105
(2022).
date_created: 2022-06-29T20:20:47Z
date_published: 2022-06-27T00:00:00Z
date_updated: 2023-08-03T07:23:52Z
day: '27'
department:
- _id: MaSe
doi: 10.1103/physrevb.105.l220203
ec_funded: 1
external_id:
arxiv:
- '2109.07332'
isi:
- '000823050000012'
intvolume: ' 105'
isi: 1
issue: '22'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: ' https://doi.org/10.48550/arXiv.2109.07332'
month: '06'
oa: 1
oa_version: Preprint
project:
- _id: 23841C26-32DE-11EA-91FC-C7463DDC885E
call_identifier: H2020
grant_number: '850899'
name: 'Non-Ergodic Quantum Matter: Universality, Dynamics and Control'
publication: Physical Review B
publication_identifier:
eissn:
- 2469-9969
issn:
- 2469-9950
publication_status: published
publisher: American Physical Society
quality_controlled: '1'
related_material:
record:
- id: '12732'
relation: dissertation_contains
status: public
status: public
title: Propagation of many-body localization in an Anderson insulator
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 105
year: '2022'
...
---
_id: '11471'
abstract:
- lang: eng
text: 'Variational quantum algorithms are promising algorithms for achieving quantum
advantage on nearterm devices. The quantum hardware is used to implement a variational
wave function and measure observables, whereas the classical computer is used
to store and update the variational parameters. The optimization landscape of
expressive variational ansätze is however dominated by large regions in parameter
space, known as barren plateaus, with vanishing gradients, which prevents efficient
optimization. In this work we propose a general algorithm to avoid barren plateaus
in the initialization and throughout the optimization. To this end we define a
notion of weak barren plateaus (WBPs) based on the entropies of local reduced
density matrices. The presence of WBPs can be efficiently quantified using recently
introduced shadow tomography of the quantum state with a classical computer. We
demonstrate that avoidance of WBPs suffices to ensure sizable gradients in the
initialization. In addition, we demonstrate that decreasing the gradient step
size, guided by the entropies allows WBPs to be avoided during the optimization
process. This paves the way for efficient barren plateau-free optimization on
near-term devices. '
acknowledgement: "We thank Marco Cerezo, Zoe Holmes, and Nicholas Hunter-Jones for
fruitful discussion and valuable feedback. We also acknowledge Adam Smith, Johannes
Jakob Meyer, and Victor V. Albert for comments on the paper. The simulations were
performed in the Julia programming\r\nlanguage [65] using the Yao module [66]. S.H.S.,
R.A.M., A.A.M. and M.S. acknowledge support by the European Research Council (ERC)
under the European Union’s Horizon 2020 research and innovation program (Grant Agreement
No. 850899)."
article_number: '020365'
article_processing_charge: No
article_type: original
arxiv: 1
author:
- first_name: Stefan
full_name: Sack, Stefan
id: dd622248-f6e0-11ea-865d-ce382a1c81a5
last_name: Sack
orcid: 0000-0001-5400-8508
- first_name: Raimel A
full_name: Medina Ramos, Raimel A
id: CE680B90-D85A-11E9-B684-C920E6697425
last_name: Medina Ramos
orcid: 0000-0002-5383-2869
- first_name: Alexios
full_name: Michailidis, Alexios
id: 36EBAD38-F248-11E8-B48F-1D18A9856A87
last_name: Michailidis
orcid: 0000-0002-8443-1064
- first_name: Richard
full_name: Kueng, Richard
last_name: Kueng
- first_name: Maksym
full_name: Serbyn, Maksym
id: 47809E7E-F248-11E8-B48F-1D18A9856A87
last_name: Serbyn
orcid: 0000-0002-2399-5827
citation:
ama: Sack S, Medina Ramos RA, Michailidis A, Kueng R, Serbyn M. Avoiding barren
plateaus using classical shadows. PRX Quantum. 2022;3(2). doi:10.1103/prxquantum.3.020365
apa: Sack, S., Medina Ramos, R. A., Michailidis, A., Kueng, R., & Serbyn, M.
(2022). Avoiding barren plateaus using classical shadows. PRX Quantum.
American Physical Society. https://doi.org/10.1103/prxquantum.3.020365
chicago: Sack, Stefan, Raimel A Medina Ramos, Alexios Michailidis, Richard Kueng,
and Maksym Serbyn. “Avoiding Barren Plateaus Using Classical Shadows.” PRX
Quantum. American Physical Society, 2022. https://doi.org/10.1103/prxquantum.3.020365.
ieee: S. Sack, R. A. Medina Ramos, A. Michailidis, R. Kueng, and M. Serbyn, “Avoiding
barren plateaus using classical shadows,” PRX Quantum, vol. 3, no. 2. American
Physical Society, 2022.
ista: Sack S, Medina Ramos RA, Michailidis A, Kueng R, Serbyn M. 2022. Avoiding
barren plateaus using classical shadows. PRX Quantum. 3(2), 020365.
mla: Sack, Stefan, et al. “Avoiding Barren Plateaus Using Classical Shadows.” PRX
Quantum, vol. 3, no. 2, 020365, American Physical Society, 2022, doi:10.1103/prxquantum.3.020365.
short: S. Sack, R.A. Medina Ramos, A. Michailidis, R. Kueng, M. Serbyn, PRX Quantum
3 (2022).
date_created: 2022-06-29T20:21:32Z
date_published: 2022-06-29T00:00:00Z
date_updated: 2023-12-13T14:47:24Z
day: '29'
ddc:
- '530'
department:
- _id: MaSe
doi: 10.1103/prxquantum.3.020365
ec_funded: 1
external_id:
arxiv:
- '2201.08194'
isi:
- '000822564300001'
file:
- access_level: open_access
checksum: a7706b28d24a0e32a55ea04b82a2df43
content_type: application/pdf
creator: dernst
date_created: 2022-06-30T07:14:48Z
date_updated: 2022-06-30T07:14:48Z
file_id: '11472'
file_name: 2022_PRXQuantum_Sack.pdf
file_size: 4231591
relation: main_file
success: 1
file_date_updated: 2022-06-30T07:14:48Z
has_accepted_license: '1'
intvolume: ' 3'
isi: 1
issue: '2'
keyword:
- General Medicine
language:
- iso: eng
month: '06'
oa: 1
oa_version: Published Version
project:
- _id: 23841C26-32DE-11EA-91FC-C7463DDC885E
call_identifier: H2020
grant_number: '850899'
name: 'Non-Ergodic Quantum Matter: Universality, Dynamics and Control'
publication: PRX Quantum
publication_identifier:
issn:
- 2691-3399
publication_status: published
publisher: American Physical Society
quality_controlled: '1'
related_material:
record:
- id: '14622'
relation: dissertation_contains
status: public
status: public
title: Avoiding barren plateaus using classical shadows
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 3
year: '2022'
...
---
_id: '11473'
abstract:
- lang: eng
text: "The polaron model is a basic model of quantum field theory describing a single
particle\r\ninteracting with a bosonic field. It arises in many physical contexts.
We are mostly concerned\r\nwith models applicable in the context of an impurity
atom in a Bose-Einstein condensate as\r\nwell as the problem of electrons moving
in polar crystals.\r\nThe model has a simple structure in which the interaction
of the particle with the field is given\r\nby a term linear in the field’s creation
and annihilation operators. In this work, we investigate\r\nthe properties of
this model by providing rigorous estimates on various energies relevant to the\r\nproblem.
The estimates are obtained, for the most part, by suitable operator techniques
which\r\nconstitute the principal mathematical substance of the thesis.\r\nThe
first application of these techniques is to derive the polaron model rigorously
from first\r\nprinciples, i.e., from a full microscopic quantum-mechanical many-body
problem involving an\r\nimpurity in an otherwise homogeneous system. We accomplish
this for the N + 1 Bose gas\r\nin the mean-field regime by showing that a suitable
polaron-type Hamiltonian arises at weak\r\ninteractions as a low-energy effective
theory for this problem.\r\nIn the second part, we investigate rigorously the
ground state of the model at fixed momentum\r\nand for large values of the coupling
constant. Qualitatively, the system is expected to display\r\na transition from
the quasi-particle behavior at small momenta, where the dispersion relation\r\nis
parabolic and the particle moves through the medium dragging along a cloud of
phonons, to\r\nthe radiative behavior at larger momenta where the polaron decelerates
and emits free phonons.\r\nAt the same time, in the strong coupling regime, the
bosonic field is expected to behave purely\r\nclassically. Accordingly, the effective
mass of the polaron at strong coupling is conjectured to\r\nbe asymptotically
equal to the one obtained from the semiclassical counterpart of the problem,\r\nfirst
studied by Landau and Pekar in the 1940s. For polaron models with regularized
form\r\nfactors and phonon dispersion relations of superfluid type, i.e., bounded
below by a linear\r\nfunction of the wavenumbers for all phonon momenta as in
the interacting Bose gas, we prove\r\nthat for a large window of momenta below
the radiation threshold, the energy-momentum\r\nrelation at strong coupling is
indeed essentially a parabola with semi-latus rectum equal to the\r\nLandau–Pekar
effective mass, as expected.\r\nFor the Fröhlich polaron describing electrons
in polar crystals where the dispersion relation is\r\nof the optical type and
the form factor is formally UV–singular due to the nature of the point\r\ncharge-dipole
interaction, we are able to give the corresponding upper bound. In contrast to\r\nthe
regular case, this requires the inclusion of the quantum fluctuations of the phonon
field,\r\nwhich makes the problem considerably more difficult.\r\nThe results
are supplemented by studies on the absolute ground-state energy at strong coupling,\r\na
proof of the divergence of the effective mass with the coupling constant for a
wide class of\r\npolaron models, as well as the discussion of the apparent UV
singularity of the Fröhlich model\r\nand the application of the techniques used
for its removal for the energy estimates.\r\n"
acknowledged_ssus:
- _id: SSU
alternative_title:
- ISTA Thesis
article_processing_charge: No
author:
- first_name: Krzysztof
full_name: Mysliwy, Krzysztof
id: 316457FC-F248-11E8-B48F-1D18A9856A87
last_name: Mysliwy
citation:
ama: 'Mysliwy K. Polarons in Bose gases and polar crystals: Some rigorous energy
estimates. 2022. doi:10.15479/at:ista:11473'
apa: 'Mysliwy, K. (2022). Polarons in Bose gases and polar crystals: Some rigorous
energy estimates. Institute of Science and Technology Austria. https://doi.org/10.15479/at:ista:11473'
chicago: 'Mysliwy, Krzysztof. “Polarons in Bose Gases and Polar Crystals: Some Rigorous
Energy Estimates.” Institute of Science and Technology Austria, 2022. https://doi.org/10.15479/at:ista:11473.'
ieee: 'K. Mysliwy, “Polarons in Bose gases and polar crystals: Some rigorous energy
estimates,” Institute of Science and Technology Austria, 2022.'
ista: 'Mysliwy K. 2022. Polarons in Bose gases and polar crystals: Some rigorous
energy estimates. Institute of Science and Technology Austria.'
mla: 'Mysliwy, Krzysztof. Polarons in Bose Gases and Polar Crystals: Some Rigorous
Energy Estimates. Institute of Science and Technology Austria, 2022, doi:10.15479/at:ista:11473.'
short: 'K. Mysliwy, Polarons in Bose Gases and Polar Crystals: Some Rigorous Energy
Estimates, Institute of Science and Technology Austria, 2022.'
date_created: 2022-06-30T12:15:03Z
date_published: 2022-07-01T00:00:00Z
date_updated: 2023-09-07T13:43:52Z
day: '01'
ddc:
- '515'
- '539'
degree_awarded: PhD
department:
- _id: GradSch
- _id: RoSe
doi: 10.15479/at:ista:11473
ec_funded: 1
file:
- access_level: open_access
checksum: 7970714a20a6052f75fb27a6c3e9976e
content_type: application/pdf
creator: kmysliwy
date_created: 2022-07-05T08:12:56Z
date_updated: 2022-07-05T08:12:56Z
file_id: '11486'
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file_size: 1830973
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checksum: 647a2011fdf56277096c9350fefe1097
content_type: application/zip
creator: kmysliwy
date_created: 2022-07-05T08:15:52Z
date_updated: 2022-07-05T08:17:12Z
file_id: '11487'
file_name: thes_source.zip
file_size: 5831060
relation: source_file
file_date_updated: 2022-07-05T08:17:12Z
has_accepted_license: '1'
language:
- iso: eng
month: '07'
oa: 1
oa_version: Published Version
page: '138'
project:
- _id: 2564DBCA-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '665385'
name: International IST Doctoral Program
publication_identifier:
issn:
- 2663-337X
publication_status: published
publisher: Institute of Science and Technology Austria
related_material:
record:
- id: '10564'
relation: part_of_dissertation
status: public
- id: '8705'
relation: part_of_dissertation
status: public
status: public
supervisor:
- first_name: Robert
full_name: Seiringer, Robert
id: 4AFD0470-F248-11E8-B48F-1D18A9856A87
last_name: Seiringer
orcid: 0000-0002-6781-0521
title: 'Polarons in Bose gases and polar crystals: Some rigorous energy estimates'
type: dissertation
user_id: c635000d-4b10-11ee-a964-aac5a93f6ac1
year: '2022'
...
---
_id: '11476'
abstract:
- lang: eng
text: "Messaging platforms like Signal are widely deployed and provide strong security
in an asynchronous setting. It is a challenging problem to construct a protocol
with similar security guarantees that can efficiently scale to large groups. A
major bottleneck are the frequent key rotations users need to perform to achieve
post compromise forward security.\r\n\r\nIn current proposals – most notably in
TreeKEM (which is part of the IETF’s Messaging Layer Security (MLS) protocol draft)
– for users in a group of size n to rotate their keys, they must each craft a
message of size log(n) to be broadcast to the group using an (untrusted) delivery
server.\r\n\r\nIn larger groups, having users sequentially rotate their keys requires
too much bandwidth (or takes too long), so variants allowing any T≤n users to
simultaneously rotate their keys in just 2 communication rounds have been suggested
(e.g. “Propose and Commit” by MLS). Unfortunately, 2-round concurrent updates
are either damaging or expensive (or both); i.e. they either result in future
operations being more costly (e.g. via “blanking” or “tainting”) or are costly
themselves requiring Ω(T) communication for each user [Bienstock et al., TCC’20].\r\n\r\nIn
this paper we propose CoCoA; a new scheme that allows for T concurrent updates
that are neither damaging nor costly. That is, they add no cost to future operations
yet they only require Ω(log2(n)) communication per user. To circumvent the [Bienstock
et al.] lower bound, CoCoA increases the number of rounds needed to complete all
updates from 2 up to (at most) log(n); though typically fewer rounds are needed.\r\n\r\nThe
key insight of our protocol is the following: in the (non-concurrent version of)
TreeKEM, a delivery server which gets T concurrent update requests will approve
one and reject the remaining T−1. In contrast, our server attempts to apply all
of them. If more than one user requests to rotate the same key during a round,
the server arbitrarily picks a winner. Surprisingly, we prove that regardless
of how the server chooses the winners, all previously compromised users will recover
after at most log(n) such update rounds.\r\n\r\nTo keep the communication complexity
low, CoCoA is a server-aided CGKA. That is, the delivery server no longer blindly
forwards packets, but instead actively computes individualized packets tailored
to each user. As the server is untrusted, this change requires us to develop new
mechanisms ensuring robustness of the protocol."
acknowledgement: We thank Marta Mularczyk and Yiannis Tselekounis for their very helpful
feedback on an earlier draft of this paper.
alternative_title:
- LNCS
article_processing_charge: No
author:
- first_name: Joël
full_name: Alwen, Joël
last_name: Alwen
- first_name: Benedikt
full_name: Auerbach, Benedikt
id: D33D2B18-E445-11E9-ABB7-15F4E5697425
last_name: Auerbach
orcid: 0000-0002-7553-6606
- first_name: Miguel
full_name: Cueto Noval, Miguel
id: ffc563a3-f6e0-11ea-865d-e3cce03d17cc
last_name: Cueto Noval
- first_name: Karen
full_name: Klein, Karen
id: 3E83A2F8-F248-11E8-B48F-1D18A9856A87
last_name: Klein
- first_name: Guillermo
full_name: Pascual Perez, Guillermo
id: 2D7ABD02-F248-11E8-B48F-1D18A9856A87
last_name: Pascual Perez
- first_name: Krzysztof Z
full_name: Pietrzak, Krzysztof Z
id: 3E04A7AA-F248-11E8-B48F-1D18A9856A87
last_name: Pietrzak
orcid: 0000-0002-9139-1654
- first_name: Michael
full_name: Walter, Michael
last_name: Walter
citation:
ama: 'Alwen J, Auerbach B, Cueto Noval M, et al. CoCoA: Concurrent continuous group
key agreement. In: Advances in Cryptology – EUROCRYPT 2022. Vol 13276.
Cham: Springer Nature; 2022:815–844. doi:10.1007/978-3-031-07085-3_28'
apa: 'Alwen, J., Auerbach, B., Cueto Noval, M., Klein, K., Pascual Perez, G., Pietrzak,
K. Z., & Walter, M. (2022). CoCoA: Concurrent continuous group key agreement.
In Advances in Cryptology – EUROCRYPT 2022 (Vol. 13276, pp. 815–844). Cham:
Springer Nature. https://doi.org/10.1007/978-3-031-07085-3_28'
chicago: 'Alwen, Joël, Benedikt Auerbach, Miguel Cueto Noval, Karen Klein, Guillermo
Pascual Perez, Krzysztof Z Pietrzak, and Michael Walter. “CoCoA: Concurrent Continuous
Group Key Agreement.” In Advances in Cryptology – EUROCRYPT 2022, 13276:815–844.
Cham: Springer Nature, 2022. https://doi.org/10.1007/978-3-031-07085-3_28.'
ieee: 'J. Alwen et al., “CoCoA: Concurrent continuous group key agreement,”
in Advances in Cryptology – EUROCRYPT 2022, Trondheim, Norway, 2022, vol.
13276, pp. 815–844.'
ista: 'Alwen J, Auerbach B, Cueto Noval M, Klein K, Pascual Perez G, Pietrzak KZ,
Walter M. 2022. CoCoA: Concurrent continuous group key agreement. Advances in
Cryptology – EUROCRYPT 2022. EUROCRYPT: Annual International Conference on the
Theory and Applications of Cryptology and Information Security, LNCS, vol. 13276,
815–844.'
mla: 'Alwen, Joël, et al. “CoCoA: Concurrent Continuous Group Key Agreement.” Advances
in Cryptology – EUROCRYPT 2022, vol. 13276, Springer Nature, 2022, pp. 815–844,
doi:10.1007/978-3-031-07085-3_28.'
short: J. Alwen, B. Auerbach, M. Cueto Noval, K. Klein, G. Pascual Perez, K.Z. Pietrzak,
M. Walter, in:, Advances in Cryptology – EUROCRYPT 2022, Springer Nature, Cham,
2022, pp. 815–844.
conference:
end_date: 2022-06-03
location: Trondheim, Norway
name: 'EUROCRYPT: Annual International Conference on the Theory and Applications
of Cryptology and Information Security'
start_date: 2022-05-30
date_created: 2022-06-30T16:48:00Z
date_published: 2022-05-25T00:00:00Z
date_updated: 2023-08-03T07:25:02Z
day: '25'
department:
- _id: GradSch
- _id: KrPi
doi: 10.1007/978-3-031-07085-3_28
ec_funded: 1
external_id:
isi:
- '000832305300028'
intvolume: ' 13276'
isi: 1
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://eprint.iacr.org/2022/251
month: '05'
oa: 1
oa_version: Preprint
page: 815–844
place: Cham
project:
- _id: 258AA5B2-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '682815'
name: Teaching Old Crypto New Tricks
- _id: 2564DBCA-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '665385'
name: International IST Doctoral Program
publication: Advances in Cryptology – EUROCRYPT 2022
publication_identifier:
eisbn:
- '9783031070853'
eissn:
- 1611-3349
isbn:
- '9783031070846'
issn:
- 0302-9743
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
scopus_import: '1'
status: public
title: 'CoCoA: Concurrent continuous group key agreement'
type: conference
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 13276
year: '2022'
...