---
_id: '792'
abstract:
- lang: eng
  text: The chaotic dynamics of low-dimensional systems, such as Lorenz or Rössler
    flows, is guided by the infinity of periodic orbits embedded in their strange
    attractors. Whether this is also the case for the infinite-dimensional dynamics
    of Navier–Stokes equations has long been speculated, and is a topic of ongoing
    study. Periodic and relative periodic solutions have been shown to be involved
    in transitions to turbulence. Their relevance to turbulent dynamics – specifically,
    whether periodic orbits play the same role in high-dimensional nonlinear systems
    like the Navier–Stokes equations as they do in lower-dimensional systems – is
    the focus of the present investigation. We perform here a detailed study of pipe
    flow relative periodic orbits with energies and mean dissipations close to turbulent
    values. We outline several approaches to reduction of the translational symmetry
    of the system. We study pipe flow in a minimal computational cell at   Re=2500,
    and report a library of invariant solutions found with the aid of the method of
    slices. Detailed study of the unstable manifolds of a sample of these solutions
    is consistent with the picture that relative periodic orbits are embedded in the
    chaotic saddle and that they guide the turbulent dynamics.
article_processing_charge: No
author:
- first_name: Nazmi B
  full_name: Budanur, Nazmi B
  id: 3EA1010E-F248-11E8-B48F-1D18A9856A87
  last_name: Budanur
  orcid: 0000-0003-0423-5010
- first_name: Kimberly
  full_name: Short, Kimberly
  last_name: Short
- first_name: Mohammad
  full_name: Farazmand, Mohammad
  last_name: Farazmand
- first_name: Ashley
  full_name: Willis, Ashley
  last_name: Willis
- first_name: Predrag
  full_name: Cvitanović, Predrag
  last_name: Cvitanović
citation:
  ama: Budanur NB, Short K, Farazmand M, Willis A, Cvitanović P. Relative periodic
    orbits form the backbone of turbulent pipe flow. <i>Journal of Fluid Mechanics</i>.
    2017;833:274-301. doi:<a href="https://doi.org/10.1017/jfm.2017.699">10.1017/jfm.2017.699</a>
  apa: Budanur, N. B., Short, K., Farazmand, M., Willis, A., &#38; Cvitanović, P.
    (2017). Relative periodic orbits form the backbone of turbulent pipe flow. <i>Journal
    of Fluid Mechanics</i>. Cambridge University Press. <a href="https://doi.org/10.1017/jfm.2017.699">https://doi.org/10.1017/jfm.2017.699</a>
  chicago: Budanur, Nazmi B, Kimberly Short, Mohammad Farazmand, Ashley Willis, and
    Predrag Cvitanović. “Relative Periodic Orbits Form the Backbone of Turbulent Pipe
    Flow.” <i>Journal of Fluid Mechanics</i>. Cambridge University Press, 2017. <a
    href="https://doi.org/10.1017/jfm.2017.699">https://doi.org/10.1017/jfm.2017.699</a>.
  ieee: N. B. Budanur, K. Short, M. Farazmand, A. Willis, and P. Cvitanović, “Relative
    periodic orbits form the backbone of turbulent pipe flow,” <i>Journal of Fluid
    Mechanics</i>, vol. 833. Cambridge University Press, pp. 274–301, 2017.
  ista: Budanur NB, Short K, Farazmand M, Willis A, Cvitanović P. 2017. Relative periodic
    orbits form the backbone of turbulent pipe flow. Journal of Fluid Mechanics. 833,
    274–301.
  mla: Budanur, Nazmi B., et al. “Relative Periodic Orbits Form the Backbone of Turbulent
    Pipe Flow.” <i>Journal of Fluid Mechanics</i>, vol. 833, Cambridge University
    Press, 2017, pp. 274–301, doi:<a href="https://doi.org/10.1017/jfm.2017.699">10.1017/jfm.2017.699</a>.
  short: N.B. Budanur, K. Short, M. Farazmand, A. Willis, P. Cvitanović, Journal of
    Fluid Mechanics 833 (2017) 274–301.
date_created: 2018-12-11T11:48:32Z
date_published: 2017-12-25T00:00:00Z
date_updated: 2023-09-27T12:17:35Z
day: '25'
department:
- _id: BjHo
doi: 10.1017/jfm.2017.699
external_id:
  isi:
  - '000414641700001'
intvolume: '       833'
isi: 1
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://arxiv.org/abs/1705.03720
month: '12'
oa: 1
oa_version: Submitted Version
page: 274 - 301
project:
- _id: 25636330-B435-11E9-9278-68D0E5697425
  grant_number: 11-NSF-1070
  name: ROOTS Genome-wide Analysis of Root Traits
publication: Journal of Fluid Mechanics
publication_identifier:
  issn:
  - '00221120'
publication_status: published
publisher: Cambridge University Press
publist_id: '6862'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Relative periodic orbits form the backbone of turbulent pipe flow
type: journal_article
user_id: c635000d-4b10-11ee-a964-aac5a93f6ac1
volume: 833
year: '2017'
...
---
_id: '793'
abstract:
- lang: eng
  text: 'Let P be a finite point set in the plane. A cordinary triangle in P is a
    subset of P consisting of three non-collinear points such that each of the three
    lines determined by the three points contains at most c points of P . Motivated
    by a question of Erdös, and answering a question of de Zeeuw, we prove that there
    exists a constant c &gt; 0such that P contains a c-ordinary triangle, provided
    that P is not contained in the union of two lines. Furthermore, the number of
    c-ordinary triangles in P is Ω(| P |). '
article_processing_charge: No
author:
- first_name: Radoslav
  full_name: Fulek, Radoslav
  id: 39F3FFE4-F248-11E8-B48F-1D18A9856A87
  last_name: Fulek
  orcid: 0000-0001-8485-1774
- first_name: Hossein
  full_name: Mojarrad, Hossein
  last_name: Mojarrad
- first_name: Márton
  full_name: Naszódi, Márton
  last_name: Naszódi
- first_name: József
  full_name: Solymosi, József
  last_name: Solymosi
- first_name: Sebastian
  full_name: Stich, Sebastian
  last_name: Stich
- first_name: May
  full_name: Szedlák, May
  last_name: Szedlák
citation:
  ama: 'Fulek R, Mojarrad H, Naszódi M, Solymosi J, Stich S, Szedlák M. On the existence
    of ordinary triangles. <i>Computational Geometry: Theory and Applications</i>.
    2017;66:28-31. doi:<a href="https://doi.org/10.1016/j.comgeo.2017.07.002">10.1016/j.comgeo.2017.07.002</a>'
  apa: 'Fulek, R., Mojarrad, H., Naszódi, M., Solymosi, J., Stich, S., &#38; Szedlák,
    M. (2017). On the existence of ordinary triangles. <i>Computational Geometry:
    Theory and Applications</i>. Elsevier. <a href="https://doi.org/10.1016/j.comgeo.2017.07.002">https://doi.org/10.1016/j.comgeo.2017.07.002</a>'
  chicago: 'Fulek, Radoslav, Hossein Mojarrad, Márton Naszódi, József Solymosi, Sebastian
    Stich, and May Szedlák. “On the Existence of Ordinary Triangles.” <i>Computational
    Geometry: Theory and Applications</i>. Elsevier, 2017. <a href="https://doi.org/10.1016/j.comgeo.2017.07.002">https://doi.org/10.1016/j.comgeo.2017.07.002</a>.'
  ieee: 'R. Fulek, H. Mojarrad, M. Naszódi, J. Solymosi, S. Stich, and M. Szedlák,
    “On the existence of ordinary triangles,” <i>Computational Geometry: Theory and
    Applications</i>, vol. 66. Elsevier, pp. 28–31, 2017.'
  ista: 'Fulek R, Mojarrad H, Naszódi M, Solymosi J, Stich S, Szedlák M. 2017. On
    the existence of ordinary triangles. Computational Geometry: Theory and Applications.
    66, 28–31.'
  mla: 'Fulek, Radoslav, et al. “On the Existence of Ordinary Triangles.” <i>Computational
    Geometry: Theory and Applications</i>, vol. 66, Elsevier, 2017, pp. 28–31, doi:<a
    href="https://doi.org/10.1016/j.comgeo.2017.07.002">10.1016/j.comgeo.2017.07.002</a>.'
  short: 'R. Fulek, H. Mojarrad, M. Naszódi, J. Solymosi, S. Stich, M. Szedlák, Computational
    Geometry: Theory and Applications 66 (2017) 28–31.'
date_created: 2018-12-11T11:48:32Z
date_published: 2017-01-01T00:00:00Z
date_updated: 2023-09-27T12:15:16Z
day: '01'
department:
- _id: UlWa
doi: 10.1016/j.comgeo.2017.07.002
ec_funded: 1
external_id:
  isi:
  - '000412039700003'
intvolume: '        66'
isi: 1
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://arxiv.org/abs/1701.08183
month: '01'
oa: 1
oa_version: Submitted Version
page: 28 - 31
project:
- _id: 25681D80-B435-11E9-9278-68D0E5697425
  call_identifier: FP7
  grant_number: '291734'
  name: International IST Postdoc Fellowship Programme
publication: 'Computational Geometry: Theory and Applications'
publication_identifier:
  issn:
  - '09257721'
publication_status: published
publisher: Elsevier
publist_id: '6861'
quality_controlled: '1'
status: public
title: On the existence of ordinary triangles
type: journal_article
user_id: c635000d-4b10-11ee-a964-aac5a93f6ac1
volume: 66
year: '2017'
...
---
_id: '794'
abstract:
- lang: eng
  text: We show that c-planarity is solvable in quadratic time for flat clustered
    graphs with three clusters if the combinatorial embedding of the underlying graph
    is fixed. In simpler graph-theoretical terms our result can be viewed as follows.
    Given a graph G with the vertex set partitioned into three parts embedded on a
    2-sphere, our algorithm decides if we can augment G by adding edges without creating
    an edge-crossing so that in the resulting spherical graph the vertices of each
    part induce a connected sub-graph. We proceed by a reduction to the problem of
    testing the existence of a perfect matching in planar bipartite graphs. We formulate
    our result in a slightly more general setting of cyclic clustered graphs, i.e.,
    the simple graph obtained by contracting each cluster, where we disregard loops
    and multi-edges, is a cycle.
acknowledgement: I would like to thank Jan Kynčl, Dömötör Pálvölgyi and anonymous
  referees for many comments and suggestions that helped to improve the presentation
  of the result.
article_processing_charge: No
author:
- first_name: Radoslav
  full_name: Fulek, Radoslav
  id: 39F3FFE4-F248-11E8-B48F-1D18A9856A87
  last_name: Fulek
  orcid: 0000-0001-8485-1774
citation:
  ama: 'Fulek R. C-planarity of embedded cyclic c-graphs. <i>Computational Geometry:
    Theory and Applications</i>. 2017;66:1-13. doi:<a href="https://doi.org/10.1016/j.comgeo.2017.06.016">10.1016/j.comgeo.2017.06.016</a>'
  apa: 'Fulek, R. (2017). C-planarity of embedded cyclic c-graphs. <i>Computational
    Geometry: Theory and Applications</i>. Elsevier. <a href="https://doi.org/10.1016/j.comgeo.2017.06.016">https://doi.org/10.1016/j.comgeo.2017.06.016</a>'
  chicago: 'Fulek, Radoslav. “C-Planarity of Embedded Cyclic c-Graphs.” <i>Computational
    Geometry: Theory and Applications</i>. Elsevier, 2017. <a href="https://doi.org/10.1016/j.comgeo.2017.06.016">https://doi.org/10.1016/j.comgeo.2017.06.016</a>.'
  ieee: 'R. Fulek, “C-planarity of embedded cyclic c-graphs,” <i>Computational Geometry:
    Theory and Applications</i>, vol. 66. Elsevier, pp. 1–13, 2017.'
  ista: 'Fulek R. 2017. C-planarity of embedded cyclic c-graphs. Computational Geometry:
    Theory and Applications. 66, 1–13.'
  mla: 'Fulek, Radoslav. “C-Planarity of Embedded Cyclic c-Graphs.” <i>Computational
    Geometry: Theory and Applications</i>, vol. 66, Elsevier, 2017, pp. 1–13, doi:<a
    href="https://doi.org/10.1016/j.comgeo.2017.06.016">10.1016/j.comgeo.2017.06.016</a>.'
  short: 'R. Fulek, Computational Geometry: Theory and Applications 66 (2017) 1–13.'
date_created: 2018-12-11T11:48:32Z
date_published: 2017-12-01T00:00:00Z
date_updated: 2023-09-27T12:14:49Z
day: '01'
department:
- _id: UlWa
doi: 10.1016/j.comgeo.2017.06.016
external_id:
  isi:
  - '000412039700001'
intvolume: '        66'
isi: 1
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://arxiv.org/abs/1602.01346
month: '12'
oa: 1
oa_version: Preprint
page: 1 - 13
publication: 'Computational Geometry: Theory and Applications'
publication_status: published
publisher: Elsevier
publist_id: '6860'
quality_controlled: '1'
related_material:
  record:
  - id: '1165'
    relation: earlier_version
    status: public
scopus_import: '1'
status: public
title: C-planarity of embedded cyclic c-graphs
type: journal_article
user_id: c635000d-4b10-11ee-a964-aac5a93f6ac1
volume: 66
year: '2017'
...
---
_id: '795'
abstract:
- lang: eng
  text: 'We introduce a common generalization of the strong Hanani–Tutte theorem and
    the weak Hanani–Tutte theorem: if a graph G has a drawing D in the plane where
    every pair of independent edges crosses an even number of times, then G has a
    planar drawing preserving the rotation of each vertex whose incident edges cross
    each other evenly in D. The theorem is implicit in the proof of the strong Hanani–Tutte
    theorem by Pelsmajer, Schaefer and Štefankovič. We give a new, somewhat simpler
    proof.'
article_number: P3.18
article_processing_charge: No
article_type: original
author:
- first_name: Radoslav
  full_name: Fulek, Radoslav
  id: 39F3FFE4-F248-11E8-B48F-1D18A9856A87
  last_name: Fulek
  orcid: 0000-0001-8485-1774
- first_name: Jan
  full_name: Kynčl, Jan
  last_name: Kynčl
- first_name: Dömötör
  full_name: Pálvölgyi, Dömötör
  last_name: Pálvölgyi
citation:
  ama: Fulek R, Kynčl J, Pálvölgyi D. Unified Hanani Tutte theorem. <i>Electronic
    Journal of Combinatorics</i>. 2017;24(3). doi:<a href="https://doi.org/10.37236/6663">10.37236/6663</a>
  apa: Fulek, R., Kynčl, J., &#38; Pálvölgyi, D. (2017). Unified Hanani Tutte theorem.
    <i>Electronic Journal of Combinatorics</i>. International Press. <a href="https://doi.org/10.37236/6663">https://doi.org/10.37236/6663</a>
  chicago: Fulek, Radoslav, Jan Kynčl, and Dömötör Pálvölgyi. “Unified Hanani Tutte
    Theorem.” <i>Electronic Journal of Combinatorics</i>. International Press, 2017.
    <a href="https://doi.org/10.37236/6663">https://doi.org/10.37236/6663</a>.
  ieee: R. Fulek, J. Kynčl, and D. Pálvölgyi, “Unified Hanani Tutte theorem,” <i>Electronic
    Journal of Combinatorics</i>, vol. 24, no. 3. International Press, 2017.
  ista: Fulek R, Kynčl J, Pálvölgyi D. 2017. Unified Hanani Tutte theorem. Electronic
    Journal of Combinatorics. 24(3), P3.18.
  mla: Fulek, Radoslav, et al. “Unified Hanani Tutte Theorem.” <i>Electronic Journal
    of Combinatorics</i>, vol. 24, no. 3, P3.18, International Press, 2017, doi:<a
    href="https://doi.org/10.37236/6663">10.37236/6663</a>.
  short: R. Fulek, J. Kynčl, D. Pálvölgyi, Electronic Journal of Combinatorics 24
    (2017).
date_created: 2018-12-11T11:48:32Z
date_published: 2017-07-28T00:00:00Z
date_updated: 2022-03-18T12:58:53Z
day: '28'
ddc:
- '000'
department:
- _id: UlWa
doi: 10.37236/6663
ec_funded: 1
file:
- access_level: open_access
  checksum: ef320cff0f062051e858f929be6a3581
  content_type: application/pdf
  creator: dernst
  date_created: 2019-01-18T14:04:08Z
  date_updated: 2020-07-14T12:48:06Z
  file_id: '5853'
  file_name: 2017_ElectrCombi_Fulek.pdf
  file_size: 236944
  relation: main_file
file_date_updated: 2020-07-14T12:48:06Z
has_accepted_license: '1'
intvolume: '        24'
issue: '3'
language:
- iso: eng
month: '07'
oa: 1
oa_version: Published Version
project:
- _id: 25681D80-B435-11E9-9278-68D0E5697425
  call_identifier: FP7
  grant_number: '291734'
  name: International IST Postdoc Fellowship Programme
publication: Electronic Journal of Combinatorics
publication_identifier:
  issn:
  - '10778926'
publication_status: published
publisher: International Press
publist_id: '6859'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Unified Hanani Tutte theorem
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 24
year: '2017'
...
---
_id: '796'
abstract:
- lang: eng
  text: We present the fabrication and characterization of an aluminum transmon qubit
    on a silicon-on-insulator substrate. Key to the qubit fabrication is the use of
    an anhydrous hydrofluoric vapor process which selectively removes the lossy silicon
    oxide buried underneath the silicon device layer. For a 5.6 GHz qubit measured
    dispersively by a 7.1 GHz resonator, we find T1 = 3.5 μs and T∗2 = 2.2 μs. This
    process in principle permits the co-fabrication of silicon photonic and mechanical
    elements, providing a route towards chip-scale integration of electro-opto-mechanical
    transducers for quantum networking of superconducting microwave quantum circuits.
    The additional processing steps are compatible with established fabrication techniques
    for aluminum transmon qubits on silicon.
acknowledgement: This work was supported by the AFOSR MURI Quantum Photonic Matter
  (Grant No. 16RT0696), the AFOSR MURI Wiring Quantum Networks with Mechanical Transducers
  (Grant No. FA9550-15-1-0015), the Institute for Quantum Information and Matter,
  an NSF Physics Frontiers Center (Grant No. PHY-1125565) with the support of the
  Gordon and Betty Moore Foundation, and the Kavli Nanoscience Institute at Caltech.
  A.J.K. acknowledges the IQIM Postdoctoral Fellowship.
article_number: '042603'
article_processing_charge: No
author:
- first_name: Andrew J
  full_name: Keller, Andrew J
  last_name: Keller
- first_name: Paul
  full_name: Dieterle, Paul
  last_name: Dieterle
- first_name: Michael
  full_name: Fang, Michael
  last_name: Fang
- first_name: Brett
  full_name: Berger, Brett
  last_name: Berger
- first_name: Johannes M
  full_name: Fink, Johannes M
  id: 4B591CBA-F248-11E8-B48F-1D18A9856A87
  last_name: Fink
  orcid: 0000-0001-8112-028X
- first_name: Oskar
  full_name: Painter, Oskar
  last_name: Painter
citation:
  ama: Keller AJ, Dieterle P, Fang M, Berger B, Fink JM, Painter O. Al transmon qubits
    on silicon on insulator for quantum device integration. <i>Applied Physics Letters</i>.
    2017;111(4). doi:<a href="https://doi.org/10.1063/1.4994661">10.1063/1.4994661</a>
  apa: Keller, A. J., Dieterle, P., Fang, M., Berger, B., Fink, J. M., &#38; Painter,
    O. (2017). Al transmon qubits on silicon on insulator for quantum device integration.
    <i>Applied Physics Letters</i>. American Institute of Physics. <a href="https://doi.org/10.1063/1.4994661">https://doi.org/10.1063/1.4994661</a>
  chicago: Keller, Andrew J, Paul Dieterle, Michael Fang, Brett Berger, Johannes M
    Fink, and Oskar Painter. “Al Transmon Qubits on Silicon on Insulator for Quantum
    Device Integration.” <i>Applied Physics Letters</i>. American Institute of Physics,
    2017. <a href="https://doi.org/10.1063/1.4994661">https://doi.org/10.1063/1.4994661</a>.
  ieee: A. J. Keller, P. Dieterle, M. Fang, B. Berger, J. M. Fink, and O. Painter,
    “Al transmon qubits on silicon on insulator for quantum device integration,” <i>Applied
    Physics Letters</i>, vol. 111, no. 4. American Institute of Physics, 2017.
  ista: Keller AJ, Dieterle P, Fang M, Berger B, Fink JM, Painter O. 2017. Al transmon
    qubits on silicon on insulator for quantum device integration. Applied Physics
    Letters. 111(4), 042603.
  mla: Keller, Andrew J., et al. “Al Transmon Qubits on Silicon on Insulator for Quantum
    Device Integration.” <i>Applied Physics Letters</i>, vol. 111, no. 4, 042603,
    American Institute of Physics, 2017, doi:<a href="https://doi.org/10.1063/1.4994661">10.1063/1.4994661</a>.
  short: A.J. Keller, P. Dieterle, M. Fang, B. Berger, J.M. Fink, O. Painter, Applied
    Physics Letters 111 (2017).
date_created: 2018-12-11T11:48:33Z
date_published: 2017-07-01T00:00:00Z
date_updated: 2023-09-27T12:13:36Z
day: '01'
department:
- _id: JoFi
doi: 10.1063/1.4994661
external_id:
  isi:
  - '000406779700031'
intvolume: '       111'
isi: 1
issue: '4'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://arxiv.org/abs/1703.10195
month: '07'
oa: 1
oa_version: Submitted Version
publication: Applied Physics Letters
publication_identifier:
  issn:
  - '00036951'
publication_status: published
publisher: American Institute of Physics
publist_id: '6857'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Al transmon qubits on silicon on insulator for quantum device integration
type: journal_article
user_id: c635000d-4b10-11ee-a964-aac5a93f6ac1
volume: 111
year: '2017'
...
---
_id: '797'
abstract:
- lang: ger
  text: Phasenübergänge helfen beim Verständnis von Vielteilchensystemen in der Festkörperphysik
    und Fluiddynamik bis hin zur Teilchenphysik. Unserer internationalen Kollaboration
    ist es gelungen, einen neuartigen Phasenübergang in einem Quantensystem zu beobachten
    [1]. In einem Mikrowellenresonator konnte erstmals die spontane Zustandsänderung
    von undurchsichtig zu transparent nachgewiesen werden.
article_processing_charge: No
article_type: original
author:
- first_name: Johannes M
  full_name: Fink, Johannes M
  id: 4B591CBA-F248-11E8-B48F-1D18A9856A87
  last_name: Fink
  orcid: 0000-0001-8112-028X
citation:
  ama: Fink JM. Photonenblockade aufgelöst. <i>Physik in unserer Zeit</i>. 2017;48(3):111-113.
    doi:<a href="https://doi.org/10.1002/piuz.201770305">10.1002/piuz.201770305</a>
  apa: Fink, J. M. (2017). Photonenblockade aufgelöst. <i>Physik in Unserer Zeit</i>.
    Wiley. <a href="https://doi.org/10.1002/piuz.201770305">https://doi.org/10.1002/piuz.201770305</a>
  chicago: Fink, Johannes M. “Photonenblockade Aufgelöst.” <i>Physik in Unserer Zeit</i>.
    Wiley, 2017. <a href="https://doi.org/10.1002/piuz.201770305">https://doi.org/10.1002/piuz.201770305</a>.
  ieee: J. M. Fink, “Photonenblockade aufgelöst,” <i>Physik in unserer Zeit</i>, vol.
    48, no. 3. Wiley, pp. 111–113, 2017.
  ista: Fink JM. 2017. Photonenblockade aufgelöst. Physik in unserer Zeit. 48(3),
    111–113.
  mla: Fink, Johannes M. “Photonenblockade Aufgelöst.” <i>Physik in Unserer Zeit</i>,
    vol. 48, no. 3, Wiley, 2017, pp. 111–13, doi:<a href="https://doi.org/10.1002/piuz.201770305">10.1002/piuz.201770305</a>.
  short: J.M. Fink, Physik in Unserer Zeit 48 (2017) 111–113.
date_created: 2018-12-11T11:48:33Z
date_published: 2017-05-01T00:00:00Z
date_updated: 2022-03-24T09:16:20Z
day: '01'
department:
- _id: JoFi
doi: 10.1002/piuz.201770305
intvolume: '        48'
issue: '3'
language:
- iso: eng
month: '05'
oa_version: None
page: 111 - 113
publication: Physik in unserer Zeit
publication_status: published
publisher: Wiley
publist_id: '6856'
quality_controlled: '1'
status: public
title: Photonenblockade aufgelöst
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 48
year: '2017'
...
---
_id: '798'
abstract:
- lang: eng
  text: Nonreciprocal circuit elements form an integral part of modern measurement
    and communication systems. Mathematically they require breaking of time-reversal
    symmetry, typically achieved using magnetic materials and more recently using
    the quantum Hall effect, parametric permittivity modulation or Josephson nonlinearities.
    Here we demonstrate an on-chip magnetic-free circulator based on reservoir-engineered
    electromechanic interactions. Directional circulation is achieved with controlled
    phase-sensitive interference of six distinct electro-mechanical signal conversion
    paths. The presented circulator is compact, its silicon-on-insulator platform
    is compatible with both superconducting qubits and silicon photonics, and its
    noise performance is close to the quantum limit. With a high dynamic range, a
    tunable bandwidth of up to 30 MHz and an in situ reconfigurability as beam splitter
    or wavelength converter, it could pave the way for superconducting qubit processors
    with multiplexed on-chip signal processing and readout.
article_number: '1304'
article_processing_charge: Yes (in subscription journal)
author:
- first_name: Shabir
  full_name: Barzanjeh, Shabir
  id: 2D25E1F6-F248-11E8-B48F-1D18A9856A87
  last_name: Barzanjeh
  orcid: 0000-0003-0415-1423
- first_name: Matthias
  full_name: Wulf, Matthias
  id: 45598606-F248-11E8-B48F-1D18A9856A87
  last_name: Wulf
  orcid: 0000-0001-6613-1378
- first_name: Matilda
  full_name: Peruzzo, Matilda
  id: 3F920B30-F248-11E8-B48F-1D18A9856A87
  last_name: Peruzzo
  orcid: 0000-0002-3415-4628
- first_name: Mahmoud
  full_name: Kalaee, Mahmoud
  last_name: Kalaee
- first_name: Paul
  full_name: Dieterle, Paul
  last_name: Dieterle
- first_name: Oskar
  full_name: Painter, Oskar
  last_name: Painter
- first_name: Johannes M
  full_name: Fink, Johannes M
  id: 4B591CBA-F248-11E8-B48F-1D18A9856A87
  last_name: Fink
  orcid: 0000-0001-8112-028X
citation:
  ama: Barzanjeh S, Wulf M, Peruzzo M, et al. Mechanical on chip microwave circulator.
    <i>Nature Communications</i>. 2017;8(1). doi:<a href="https://doi.org/10.1038/s41467-017-01304-x">10.1038/s41467-017-01304-x</a>
  apa: Barzanjeh, S., Wulf, M., Peruzzo, M., Kalaee, M., Dieterle, P., Painter, O.,
    &#38; Fink, J. M. (2017). Mechanical on chip microwave circulator. <i>Nature Communications</i>.
    Nature Publishing Group. <a href="https://doi.org/10.1038/s41467-017-01304-x">https://doi.org/10.1038/s41467-017-01304-x</a>
  chicago: Barzanjeh, Shabir, Matthias Wulf, Matilda Peruzzo, Mahmoud Kalaee, Paul
    Dieterle, Oskar Painter, and Johannes M Fink. “Mechanical on Chip Microwave Circulator.”
    <i>Nature Communications</i>. Nature Publishing Group, 2017. <a href="https://doi.org/10.1038/s41467-017-01304-x">https://doi.org/10.1038/s41467-017-01304-x</a>.
  ieee: S. Barzanjeh <i>et al.</i>, “Mechanical on chip microwave circulator,” <i>Nature
    Communications</i>, vol. 8, no. 1. Nature Publishing Group, 2017.
  ista: Barzanjeh S, Wulf M, Peruzzo M, Kalaee M, Dieterle P, Painter O, Fink JM.
    2017. Mechanical on chip microwave circulator. Nature Communications. 8(1), 1304.
  mla: Barzanjeh, Shabir, et al. “Mechanical on Chip Microwave Circulator.” <i>Nature
    Communications</i>, vol. 8, no. 1, 1304, Nature Publishing Group, 2017, doi:<a
    href="https://doi.org/10.1038/s41467-017-01304-x">10.1038/s41467-017-01304-x</a>.
  short: S. Barzanjeh, M. Wulf, M. Peruzzo, M. Kalaee, P. Dieterle, O. Painter, J.M.
    Fink, Nature Communications 8 (2017).
date_created: 2018-12-11T11:48:33Z
date_published: 2017-10-16T00:00:00Z
date_updated: 2023-09-27T12:11:28Z
day: '16'
ddc:
- '539'
department:
- _id: JoFi
doi: 10.1038/s41467-017-01304-x
ec_funded: 1
external_id:
  isi:
  - '000412999700021'
file:
- access_level: open_access
  checksum: b68dafa71d1834c23b742cd9987a3d5f
  content_type: application/pdf
  creator: system
  date_created: 2018-12-12T10:15:25Z
  date_updated: 2020-07-14T12:48:06Z
  file_id: '5145'
  file_name: IST-2017-867-v1+1_s41467-017-01304-x.pdf
  file_size: 1467696
  relation: main_file
file_date_updated: 2020-07-14T12:48:06Z
has_accepted_license: '1'
intvolume: '         8'
isi: 1
issue: '1'
language:
- iso: eng
month: '10'
oa: 1
oa_version: Published Version
project:
- _id: 257EB838-B435-11E9-9278-68D0E5697425
  call_identifier: H2020
  grant_number: '732894'
  name: Hybrid Optomechanical Technologies
- _id: 258047B6-B435-11E9-9278-68D0E5697425
  call_identifier: H2020
  grant_number: '707438'
  name: 'Microwave-to-Optical Quantum Link: Quantum Teleportation and Quantum Illumination
    with cavity Optomechanics'
publication: Nature Communications
publication_identifier:
  issn:
  - '20411723'
publication_status: published
publisher: Nature Publishing Group
publist_id: '6855'
pubrep_id: '867'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Mechanical on chip microwave circulator
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: c635000d-4b10-11ee-a964-aac5a93f6ac1
volume: 8
year: '2017'
...
---
_id: '799'
abstract:
- lang: eng
  text: Membrane traffic at the trans-Golgi network (TGN) is crucial for correctly
    distributing various membrane proteins to their destination. Polarly localized
    auxin efflux proteins, including PIN-FORMED1 (PIN1), are dynamically transported
    between the endosomes and the plasma membrane (PM) in the plant cells. The intracellular
    trafficking of PIN1 protein is sensitive to a fungal toxin brefeldin A (BFA),
    which is known to inhibit guanine-nucleotide exchange factors for ADP ribosylation
    factors (ARF GEFs) such as GNOM. However, the molecular details of the BFA-sensitive
    trafficking pathway have not been revealed fully. In a previous study, we have
    identified an Arabidopsis mutant BFA-visualized endocytic trafficking defective
    3 (ben3) which exhibited reduced sensitivity to BFA in terms of BFA-induced intracellular
    PIN1 agglomeration. Here, we show that BEN3 encodes a member of BIG family ARF
    GEFs, BIG2. Fluorescent proteins tagged BEN3/BIG2 co-localized with markers for
    TGN / early endosome (EE). Inspection of conditionally induced de novo synthesized
    PIN1 confirmed that its secretion to the PM is BFA-sensitive and established BEN3/BIG2
    as a crucial component of this BFA action at the level of TGN/EE. Furthermore,
    ben3 mutation alleviated BFA-induced agglomeration of another TGN-localized ARF
    GEF BEN1/MIN7. Taken together our results suggest that BEN3/BIG2 is an ARF GEF
    component, which confers BFA sensitivity to the TGN/EE in Arabidopsis.
article_number: 1801-1811
article_processing_charge: No
author:
- first_name: Saeko
  full_name: Kitakura, Saeko
  last_name: Kitakura
- first_name: Maciek
  full_name: Adamowski, Maciek
  id: 45F536D2-F248-11E8-B48F-1D18A9856A87
  last_name: Adamowski
  orcid: 0000-0001-6463-5257
- first_name: Yuki
  full_name: Matsuura, Yuki
  last_name: Matsuura
- first_name: Luca
  full_name: Santuari, Luca
  last_name: Santuari
- first_name: Hirotaka
  full_name: Kouno, Hirotaka
  last_name: Kouno
- first_name: Kohei
  full_name: Arima, Kohei
  last_name: Arima
- first_name: Christian
  full_name: Hardtke, Christian
  last_name: Hardtke
- first_name: Jirí
  full_name: Friml, Jirí
  id: 4159519E-F248-11E8-B48F-1D18A9856A87
  last_name: Friml
  orcid: 0000-0002-8302-7596
- first_name: Tatsuo
  full_name: Kakimoto, Tatsuo
  last_name: Kakimoto
- first_name: Hirokazu
  full_name: Tanaka, Hirokazu
  last_name: Tanaka
citation:
  ama: Kitakura S, Adamowski M, Matsuura Y, et al. BEN3/BIG2 ARF GEF is involved in
    brefeldin a-sensitive trafficking at the trans-Golgi network/early endosome in
    Arabidopsis thaliana. <i>Plant and Cell Physiology</i>. 2017;58(10). doi:<a href="https://doi.org/10.1093/pcp/pcx118">10.1093/pcp/pcx118</a>
  apa: Kitakura, S., Adamowski, M., Matsuura, Y., Santuari, L., Kouno, H., Arima,
    K., … Tanaka, H. (2017). BEN3/BIG2 ARF GEF is involved in brefeldin a-sensitive
    trafficking at the trans-Golgi network/early endosome in Arabidopsis thaliana.
    <i>Plant and Cell Physiology</i>. Oxford University Press. <a href="https://doi.org/10.1093/pcp/pcx118">https://doi.org/10.1093/pcp/pcx118</a>
  chicago: Kitakura, Saeko, Maciek Adamowski, Yuki Matsuura, Luca Santuari, Hirotaka
    Kouno, Kohei Arima, Christian Hardtke, Jiří Friml, Tatsuo Kakimoto, and Hirokazu
    Tanaka. “BEN3/BIG2 ARF GEF Is Involved in Brefeldin a-Sensitive Trafficking at
    the Trans-Golgi Network/Early Endosome in Arabidopsis Thaliana.” <i>Plant and
    Cell Physiology</i>. Oxford University Press, 2017. <a href="https://doi.org/10.1093/pcp/pcx118">https://doi.org/10.1093/pcp/pcx118</a>.
  ieee: S. Kitakura <i>et al.</i>, “BEN3/BIG2 ARF GEF is involved in brefeldin a-sensitive
    trafficking at the trans-Golgi network/early endosome in Arabidopsis thaliana,”
    <i>Plant and Cell Physiology</i>, vol. 58, no. 10. Oxford University Press, 2017.
  ista: Kitakura S, Adamowski M, Matsuura Y, Santuari L, Kouno H, Arima K, Hardtke
    C, Friml J, Kakimoto T, Tanaka H. 2017. BEN3/BIG2 ARF GEF is involved in brefeldin
    a-sensitive trafficking at the trans-Golgi network/early endosome in Arabidopsis
    thaliana. Plant and Cell Physiology. 58(10), 1801–1811.
  mla: Kitakura, Saeko, et al. “BEN3/BIG2 ARF GEF Is Involved in Brefeldin a-Sensitive
    Trafficking at the Trans-Golgi Network/Early Endosome in Arabidopsis Thaliana.”
    <i>Plant and Cell Physiology</i>, vol. 58, no. 10, 1801–1811, Oxford University
    Press, 2017, doi:<a href="https://doi.org/10.1093/pcp/pcx118">10.1093/pcp/pcx118</a>.
  short: S. Kitakura, M. Adamowski, Y. Matsuura, L. Santuari, H. Kouno, K. Arima,
    C. Hardtke, J. Friml, T. Kakimoto, H. Tanaka, Plant and Cell Physiology 58 (2017).
date_created: 2018-12-11T11:48:34Z
date_published: 2017-08-21T00:00:00Z
date_updated: 2023-09-27T11:00:19Z
day: '21'
ddc:
- '581'
department:
- _id: JiFr
doi: 10.1093/pcp/pcx118
external_id:
  isi:
  - '000413220400019'
  pmid:
  - '29016942'
file:
- access_level: open_access
  checksum: bd3e3a94d55416739cbb19624bb977f8
  content_type: application/pdf
  creator: dernst
  date_created: 2019-04-17T07:52:34Z
  date_updated: 2020-07-14T12:48:06Z
  file_id: '6333'
  file_name: 2017_PlantCellPhysio_Kitakura.pdf
  file_size: 1352913
  relation: main_file
file_date_updated: 2020-07-14T12:48:06Z
has_accepted_license: '1'
intvolume: '        58'
isi: 1
issue: '10'
language:
- iso: eng
month: '08'
oa: 1
oa_version: Submitted Version
pmid: 1
publication: Plant and Cell Physiology
publication_identifier:
  issn:
  - '00320781'
publication_status: published
publisher: Oxford University Press
publist_id: '6854'
pubrep_id: '1009'
quality_controlled: '1'
scopus_import: '1'
status: public
title: BEN3/BIG2 ARF GEF is involved in brefeldin a-sensitive trafficking at the trans-Golgi
  network/early endosome in Arabidopsis thaliana
type: journal_article
user_id: c635000d-4b10-11ee-a964-aac5a93f6ac1
volume: 58
year: '2017'
...
---
_id: '800'
abstract:
- lang: eng
  text: Gamma oscillations (30–150 Hz) in neuronal networks are associated with the
    processing and recall of information. We measured local field potentials in the
    dentate gyrus of freely moving mice and found that gamma activity occurs in bursts,
    which are highly heterogeneous in their spatial extensions, ranging from focal
    to global coherent events. Synaptic communication among perisomatic-inhibitory
    interneurons (PIIs) is thought to play an important role in the generation of
    hippocampal gamma patterns. However, how neuronal circuits can generate synchronous
    oscillations at different spatial scales is unknown. We analyzed paired recordings
    in dentate gyrus slices and show that synaptic signaling at interneuron-interneuron
    synapses is distance dependent. Synaptic strength declines whereas the duration
    of inhibitory signals increases with axonal distance among interconnected PIIs.
    Using neuronal network modeling, we show that distance-dependent inhibition generates
    multiple highly synchronous focal gamma bursts allowing the network to process
    complex inputs in parallel in flexibly organized neuronal centers.
article_number: '758'
article_processing_charge: No
author:
- first_name: Michael
  full_name: Strüber, Michael
  last_name: Strüber
- first_name: Jonas
  full_name: Sauer, Jonas
  last_name: Sauer
- first_name: Peter M
  full_name: Jonas, Peter M
  id: 353C1B58-F248-11E8-B48F-1D18A9856A87
  last_name: Jonas
  orcid: 0000-0001-5001-4804
- first_name: Marlene
  full_name: Bartos, Marlene
  last_name: Bartos
citation:
  ama: Strüber M, Sauer J, Jonas PM, Bartos M. Distance-dependent inhibition facilitates
    focality of gamma oscillations in the dentate gyrus. <i>Nature Communications</i>.
    2017;8(1). doi:<a href="https://doi.org/10.1038/s41467-017-00936-3">10.1038/s41467-017-00936-3</a>
  apa: Strüber, M., Sauer, J., Jonas, P. M., &#38; Bartos, M. (2017). Distance-dependent
    inhibition facilitates focality of gamma oscillations in the dentate gyrus. <i>Nature
    Communications</i>. Nature Publishing Group. <a href="https://doi.org/10.1038/s41467-017-00936-3">https://doi.org/10.1038/s41467-017-00936-3</a>
  chicago: Strüber, Michael, Jonas Sauer, Peter M Jonas, and Marlene Bartos. “Distance-Dependent
    Inhibition Facilitates Focality of Gamma Oscillations in the Dentate Gyrus.” <i>Nature
    Communications</i>. Nature Publishing Group, 2017. <a href="https://doi.org/10.1038/s41467-017-00936-3">https://doi.org/10.1038/s41467-017-00936-3</a>.
  ieee: M. Strüber, J. Sauer, P. M. Jonas, and M. Bartos, “Distance-dependent inhibition
    facilitates focality of gamma oscillations in the dentate gyrus,” <i>Nature Communications</i>,
    vol. 8, no. 1. Nature Publishing Group, 2017.
  ista: Strüber M, Sauer J, Jonas PM, Bartos M. 2017. Distance-dependent inhibition
    facilitates focality of gamma oscillations in the dentate gyrus. Nature Communications.
    8(1), 758.
  mla: Strüber, Michael, et al. “Distance-Dependent Inhibition Facilitates Focality
    of Gamma Oscillations in the Dentate Gyrus.” <i>Nature Communications</i>, vol.
    8, no. 1, 758, Nature Publishing Group, 2017, doi:<a href="https://doi.org/10.1038/s41467-017-00936-3">10.1038/s41467-017-00936-3</a>.
  short: M. Strüber, J. Sauer, P.M. Jonas, M. Bartos, Nature Communications 8 (2017).
date_created: 2018-12-11T11:48:34Z
date_published: 2017-10-02T00:00:00Z
date_updated: 2023-09-27T10:59:41Z
day: '02'
ddc:
- '571'
department:
- _id: PeJo
doi: 10.1038/s41467-017-00936-3
ec_funded: 1
external_id:
  isi:
  - '000412053100004'
file:
- access_level: open_access
  checksum: 7e2c7621afd5f802338e92e8619f024d
  content_type: application/pdf
  creator: system
  date_created: 2018-12-12T10:15:17Z
  date_updated: 2020-07-14T12:48:07Z
  file_id: '5135'
  file_name: IST-2017-914-v1+1_s41467-017-00936-3.pdf
  file_size: 4261832
  relation: main_file
file_date_updated: 2020-07-14T12:48:07Z
has_accepted_license: '1'
intvolume: '         8'
isi: 1
issue: '1'
language:
- iso: eng
month: '10'
oa: 1
oa_version: Published Version
project:
- _id: 25C0F108-B435-11E9-9278-68D0E5697425
  call_identifier: FP7
  grant_number: '268548'
  name: Nanophysiology of fast-spiking, parvalbumin-expressing GABAergic interneurons
publication: Nature Communications
publication_identifier:
  issn:
  - '20411723'
publication_status: published
publisher: Nature Publishing Group
publist_id: '6853'
pubrep_id: '914'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Distance-dependent inhibition facilitates focality of gamma oscillations in
  the dentate gyrus
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: c635000d-4b10-11ee-a964-aac5a93f6ac1
volume: 8
year: '2017'
...
---
_id: '803'
abstract:
- lang: eng
  text: Eukaryotic cells store their chromosomes in a single nucleus. This is important
    to maintain genomic integrity, as chromosomes packaged into separate nuclei (micronuclei)
    are prone to massive DNA damage. During mitosis, higher eukaryotes disassemble
    their nucleus and release individualized chromosomes for segregation. How numerous
    chromosomes subsequently reform a single nucleus has remained unclear. Using image-based
    screening of human cells, we identified barrier-to-autointegration factor (BAF)
    as a key factor guiding membranes to form a single nucleus. Unexpectedly, nuclear
    assembly does not require BAF?s association with inner nuclear membrane proteins
    but instead relies on BAF?s ability to bridge distant DNA sites. Live-cell imaging
    and in vitro reconstitution showed that BAF enriches around the mitotic chromosome
    ensemble to induce a densely cross-bridged chromatin layer that is mechanically
    stiff and limits membranes to the surface. Our study reveals that BAF-mediated
    changes in chromosome mechanics underlie nuclear assembly with broad implications
    for proper genome function.
acknowledged_ssus:
- _id: Bio
article_processing_charge: No
author:
- first_name: Matthias
  full_name: Samwer, Matthias
  last_name: Samwer
- first_name: Maximilian
  full_name: Schneider, Maximilian
  last_name: Schneider
- first_name: Rudolf
  full_name: Hoefler, Rudolf
  last_name: Hoefler
- first_name: Philipp S
  full_name: Schmalhorst, Philipp S
  id: 309D50DA-F248-11E8-B48F-1D18A9856A87
  last_name: Schmalhorst
  orcid: 0000-0002-5795-0133
- first_name: Julian
  full_name: Jude, Julian
  last_name: Jude
- first_name: Johannes
  full_name: Zuber, Johannes
  last_name: Zuber
- first_name: Daniel
  full_name: Gerlic, Daniel
  last_name: Gerlic
citation:
  ama: Samwer M, Schneider M, Hoefler R, et al. DNA cross-bridging shapes a single
    nucleus from a set of mitotic chromosomes. <i>Cell</i>. 2017;170(5):956-972. doi:<a
    href="https://doi.org/10.1016/j.cell.2017.07.038">10.1016/j.cell.2017.07.038</a>
  apa: Samwer, M., Schneider, M., Hoefler, R., Schmalhorst, P. S., Jude, J., Zuber,
    J., &#38; Gerlic, D. (2017). DNA cross-bridging shapes a single nucleus from a
    set of mitotic chromosomes. <i>Cell</i>. Cell Press. <a href="https://doi.org/10.1016/j.cell.2017.07.038">https://doi.org/10.1016/j.cell.2017.07.038</a>
  chicago: Samwer, Matthias, Maximilian Schneider, Rudolf Hoefler, Philipp S Schmalhorst,
    Julian Jude, Johannes Zuber, and Daniel Gerlic. “DNA Cross-Bridging Shapes a Single
    Nucleus from a Set of Mitotic Chromosomes.” <i>Cell</i>. Cell Press, 2017. <a
    href="https://doi.org/10.1016/j.cell.2017.07.038">https://doi.org/10.1016/j.cell.2017.07.038</a>.
  ieee: M. Samwer <i>et al.</i>, “DNA cross-bridging shapes a single nucleus from
    a set of mitotic chromosomes,” <i>Cell</i>, vol. 170, no. 5. Cell Press, pp. 956–972,
    2017.
  ista: Samwer M, Schneider M, Hoefler R, Schmalhorst PS, Jude J, Zuber J, Gerlic
    D. 2017. DNA cross-bridging shapes a single nucleus from a set of mitotic chromosomes.
    Cell. 170(5), 956–972.
  mla: Samwer, Matthias, et al. “DNA Cross-Bridging Shapes a Single Nucleus from a
    Set of Mitotic Chromosomes.” <i>Cell</i>, vol. 170, no. 5, Cell Press, 2017, pp.
    956–72, doi:<a href="https://doi.org/10.1016/j.cell.2017.07.038">10.1016/j.cell.2017.07.038</a>.
  short: M. Samwer, M. Schneider, R. Hoefler, P.S. Schmalhorst, J. Jude, J. Zuber,
    D. Gerlic, Cell 170 (2017) 956–972.
date_created: 2018-12-11T11:48:35Z
date_published: 2017-08-24T00:00:00Z
date_updated: 2023-09-27T10:59:14Z
day: '24'
ddc:
- '570'
department:
- _id: CaHe
doi: 10.1016/j.cell.2017.07.038
external_id:
  isi:
  - '000408372400014'
file:
- access_level: open_access
  checksum: 64897b0c5373f22273f598e4672c60ff
  content_type: application/pdf
  creator: dernst
  date_created: 2019-01-18T13:45:40Z
  date_updated: 2020-07-14T12:48:08Z
  file_id: '5852'
  file_name: 2017_Cell_Samwer.pdf
  file_size: 17666637
  relation: main_file
file_date_updated: 2020-07-14T12:48:08Z
has_accepted_license: '1'
intvolume: '       170'
isi: 1
issue: '5'
language:
- iso: eng
month: '08'
oa: 1
oa_version: Published Version
page: 956 - 972
publication: Cell
publication_identifier:
  issn:
  - '00928674'
publication_status: published
publisher: Cell Press
publist_id: '6848'
quality_controlled: '1'
scopus_import: '1'
status: public
title: DNA cross-bridging shapes a single nucleus from a set of mitotic chromosomes
tmp:
  image: /images/cc_by_nc_nd.png
  legal_code_url: https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode
  name: Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
    (CC BY-NC-ND 4.0)
  short: CC BY-NC-ND (4.0)
type: journal_article
user_id: c635000d-4b10-11ee-a964-aac5a93f6ac1
volume: 170
year: '2017'
...
---
_id: '804'
abstract:
- lang: eng
  text: Polysaccharides (carbohydrates) are key regulators of a large number of cell
    biological processes. However, precise biochemical or genetic manipulation of
    these often complex structures is laborious and hampers experimental structure–function
    studies. Molecular Dynamics (MD) simulations provide a valuable alternative tool
    to generate and test hypotheses on saccharide function. Yet, currently used MD
    force fields often overestimate the aggregation propensity of polysaccharides,
    affecting the usability of those simulations. Here we tested MARTINI, a popular
    coarse-grained (CG) force field for biological macromolecules, for its ability
    to accurately represent molecular forces between saccharides. To this end, we
    calculated a thermodynamic solution property, the second virial coefficient of
    the osmotic pressure (B22). Comparison with light scattering experiments revealed
    a nonphysical aggregation of a prototypical polysaccharide in MARTINI, pointing
    at an imbalance of the nonbonded solute–solute, solute–water, and water–water
    interactions. This finding also applies to smaller oligosaccharides which were
    all found to aggregate in simulations even at moderate concentrations, well below
    their solubility limit. Finally, we explored the influence of the Lennard-Jones
    (LJ) interaction between saccharide molecules and propose a simple scaling of
    the LJ interaction strength that makes MARTINI more reliable for the simulation
    of saccharides.
acknowledged_ssus:
- _id: ScienComp
acknowledgement: P.S.S. was supported by research fellowship 2811/1-1 from the German
  Research Foundation (DFG), and M.S. was supported by EMBO Long Term Fellowship ALTF
  187-2013 and Grant GC65-32 from the  Interdisciplinary Centre for Mathematical and
  Computational Modelling (ICM), University of Warsaw, Poland. The authors thank Antje
  Potthast, Marek Cieplak, Tomasz Włodarski, and Damien Thompson for fruitful discussions
  and the IST Austria Scientific Computing Facility for support.
article_processing_charge: No
author:
- first_name: Philipp S
  full_name: Schmalhorst, Philipp S
  id: 309D50DA-F248-11E8-B48F-1D18A9856A87
  last_name: Schmalhorst
  orcid: 0000-0002-5795-0133
- first_name: Felix
  full_name: Deluweit, Felix
  last_name: Deluweit
- first_name: Roger
  full_name: Scherrers, Roger
  last_name: Scherrers
- first_name: Carl-Philipp J
  full_name: Heisenberg, Carl-Philipp J
  id: 39427864-F248-11E8-B48F-1D18A9856A87
  last_name: Heisenberg
  orcid: 0000-0002-0912-4566
- first_name: Mateusz K
  full_name: Sikora, Mateusz K
  id: 2F74BCDE-F248-11E8-B48F-1D18A9856A87
  last_name: Sikora
citation:
  ama: Schmalhorst PS, Deluweit F, Scherrers R, Heisenberg C-PJ, Sikora MK. Overcoming
    the limitations of the MARTINI force field in simulations of polysaccharides.
    <i>Journal of Chemical Theory and Computation</i>. 2017;13(10):5039-5053. doi:<a
    href="https://doi.org/10.1021/acs.jctc.7b00374">10.1021/acs.jctc.7b00374</a>
  apa: Schmalhorst, P. S., Deluweit, F., Scherrers, R., Heisenberg, C.-P. J., &#38;
    Sikora, M. K. (2017). Overcoming the limitations of the MARTINI force field in
    simulations of polysaccharides. <i>Journal of Chemical Theory and Computation</i>.
    American Chemical Society. <a href="https://doi.org/10.1021/acs.jctc.7b00374">https://doi.org/10.1021/acs.jctc.7b00374</a>
  chicago: Schmalhorst, Philipp S, Felix Deluweit, Roger Scherrers, Carl-Philipp J
    Heisenberg, and Mateusz K Sikora. “Overcoming the Limitations of the MARTINI Force
    Field in Simulations of Polysaccharides.” <i>Journal of Chemical Theory and Computation</i>.
    American Chemical Society, 2017. <a href="https://doi.org/10.1021/acs.jctc.7b00374">https://doi.org/10.1021/acs.jctc.7b00374</a>.
  ieee: P. S. Schmalhorst, F. Deluweit, R. Scherrers, C.-P. J. Heisenberg, and M.
    K. Sikora, “Overcoming the limitations of the MARTINI force field in simulations
    of polysaccharides,” <i>Journal of Chemical Theory and Computation</i>, vol. 13,
    no. 10. American Chemical Society, pp. 5039–5053, 2017.
  ista: Schmalhorst PS, Deluweit F, Scherrers R, Heisenberg C-PJ, Sikora MK. 2017.
    Overcoming the limitations of the MARTINI force field in simulations of polysaccharides.
    Journal of Chemical Theory and Computation. 13(10), 5039–5053.
  mla: Schmalhorst, Philipp S., et al. “Overcoming the Limitations of the MARTINI
    Force Field in Simulations of Polysaccharides.” <i>Journal of Chemical Theory
    and Computation</i>, vol. 13, no. 10, American Chemical Society, 2017, pp. 5039–53,
    doi:<a href="https://doi.org/10.1021/acs.jctc.7b00374">10.1021/acs.jctc.7b00374</a>.
  short: P.S. Schmalhorst, F. Deluweit, R. Scherrers, C.-P.J. Heisenberg, M.K. Sikora,
    Journal of Chemical Theory and Computation 13 (2017) 5039–5053.
date_created: 2018-12-11T11:48:35Z
date_published: 2017-10-10T00:00:00Z
date_updated: 2023-09-27T10:58:45Z
day: '10'
department:
- _id: CaHe
doi: 10.1021/acs.jctc.7b00374
external_id:
  isi:
  - '000412965700036'
intvolume: '        13'
isi: 1
issue: '10'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://arxiv.org/abs/1704.03773
month: '10'
oa: 1
oa_version: Submitted Version
page: 5039 - 5053
publication: Journal of Chemical Theory and Computation
publication_identifier:
  issn:
  - '15499618'
publication_status: published
publisher: American Chemical Society
publist_id: '6847'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Overcoming the limitations of the MARTINI force field in simulations of polysaccharides
type: journal_article
user_id: c635000d-4b10-11ee-a964-aac5a93f6ac1
volume: 13
year: '2017'
...
---
_id: '805'
abstract:
- lang: eng
  text: During corticogenesis, distinct classes of neurons are born from progenitor
    cells located in the ventricular and subventricular zones, from where they migrate
    towards the pial surface to assemble into highly organized layer-specific circuits.
    However, the precise and coordinated transcriptional network activity defining
    neuronal identity is still not understood. Here, we show that genetic depletion
    of the basic helix-loop-helix (bHLH) transcription factor E2A splice variant E47
    increased the number of Tbr1-positive deep layer and Satb2-positive upper layer
    neurons at E14.5, while depletion of the alternatively spliced E12 variant did
    not affect layer-specific neurogenesis. While ChIP-Seq identified a big overlap
    for E12- and E47-specific binding sites in embryonic NSCs, including sites at
    the cyclin-dependent kinase inhibitor (CDKI) Cdkn1c gene locus, RNA-Seq revealed
    a unique transcriptional regulation by each splice variant. E47 activated the
    expression of the CDKI Cdkn1c through binding to a distal enhancer. Finally, overexpression
    of E47 in embryonic NSCs in vitro impaired neurite outgrowth and E47 overexpression
    in vivo by in utero electroporation disturbed proper layer-specific neurogenesis
    and upregulated p57(KIP2) expression. Overall, this study identified E2A target
    genes in embryonic NSCs and demonstrates that E47 regulates neuronal differentiation
    via p57(KIP2).
article_processing_charge: No
author:
- first_name: Sabrina
  full_name: Pfurr, Sabrina
  last_name: Pfurr
- first_name: Yu
  full_name: Chu, Yu
  last_name: Chu
- first_name: Christian
  full_name: Bohrer, Christian
  last_name: Bohrer
- first_name: Franziska
  full_name: Greulich, Franziska
  last_name: Greulich
- first_name: Robert J
  full_name: Beattie, Robert J
  id: 2E26DF60-F248-11E8-B48F-1D18A9856A87
  last_name: Beattie
  orcid: 0000-0002-8483-8753
- first_name: Könül
  full_name: Mammadzada, Könül
  last_name: Mammadzada
- first_name: Miriam
  full_name: Hils, Miriam
  last_name: Hils
- first_name: Sebastian
  full_name: Arnold, Sebastian
  last_name: Arnold
- first_name: Verdon
  full_name: Taylor, Verdon
  last_name: Taylor
- first_name: Kristina
  full_name: Schachtrup, Kristina
  last_name: Schachtrup
- first_name: N Henriette
  full_name: Uhlenhaut, N Henriette
  last_name: Uhlenhaut
- first_name: Christian
  full_name: Schachtrup, Christian
  last_name: Schachtrup
citation:
  ama: Pfurr S, Chu Y, Bohrer C, et al. The E2A splice variant E47 regulates the differentiation
    of projection neurons via p57(KIP2) during cortical development. <i>Development</i>.
    2017;144:3917-3931. doi:<a href="https://doi.org/10.1242/dev.145698">10.1242/dev.145698</a>
  apa: Pfurr, S., Chu, Y., Bohrer, C., Greulich, F., Beattie, R. J., Mammadzada, K.,
    … Schachtrup, C. (2017). The E2A splice variant E47 regulates the differentiation
    of projection neurons via p57(KIP2) during cortical development. <i>Development</i>.
    Company of Biologists. <a href="https://doi.org/10.1242/dev.145698">https://doi.org/10.1242/dev.145698</a>
  chicago: Pfurr, Sabrina, Yu Chu, Christian Bohrer, Franziska Greulich, Robert J
    Beattie, Könül Mammadzada, Miriam Hils, et al. “The E2A Splice Variant E47 Regulates
    the Differentiation of Projection Neurons via P57(KIP2) during Cortical Development.”
    <i>Development</i>. Company of Biologists, 2017. <a href="https://doi.org/10.1242/dev.145698">https://doi.org/10.1242/dev.145698</a>.
  ieee: S. Pfurr <i>et al.</i>, “The E2A splice variant E47 regulates the differentiation
    of projection neurons via p57(KIP2) during cortical development,” <i>Development</i>,
    vol. 144. Company of Biologists, pp. 3917–3931, 2017.
  ista: Pfurr S, Chu Y, Bohrer C, Greulich F, Beattie RJ, Mammadzada K, Hils M, Arnold
    S, Taylor V, Schachtrup K, Uhlenhaut NH, Schachtrup C. 2017. The E2A splice variant
    E47 regulates the differentiation of projection neurons via p57(KIP2) during cortical
    development. Development. 144, 3917–3931.
  mla: Pfurr, Sabrina, et al. “The E2A Splice Variant E47 Regulates the Differentiation
    of Projection Neurons via P57(KIP2) during Cortical Development.” <i>Development</i>,
    vol. 144, Company of Biologists, 2017, pp. 3917–31, doi:<a href="https://doi.org/10.1242/dev.145698">10.1242/dev.145698</a>.
  short: S. Pfurr, Y. Chu, C. Bohrer, F. Greulich, R.J. Beattie, K. Mammadzada, M.
    Hils, S. Arnold, V. Taylor, K. Schachtrup, N.H. Uhlenhaut, C. Schachtrup, Development
    144 (2017) 3917–3931.
date_created: 2018-12-11T11:48:36Z
date_published: 2017-10-31T00:00:00Z
date_updated: 2023-09-26T16:20:09Z
day: '31'
department:
- _id: SiHi
doi: 10.1242/dev.145698
external_id:
  isi:
  - '000414025600007'
intvolume: '       144'
isi: 1
language:
- iso: eng
month: '10'
oa_version: None
page: 3917 - 3931
publication: Development
publication_status: published
publisher: Company of Biologists
publist_id: '6846'
quality_controlled: '1'
scopus_import: '1'
status: public
title: The E2A splice variant E47 regulates the differentiation of projection neurons
  via p57(KIP2) during cortical development
type: journal_article
user_id: c635000d-4b10-11ee-a964-aac5a93f6ac1
volume: 144
year: '2017'
...
---
_id: '807'
abstract:
- lang: eng
  text: 'On January the 1st, 2016 a new agreement between 32 Austrian scientific libraries
    and the publisher Springer took its effect: this deal covers accessing the licensed
    content on the one hand, and publishing open access on the other hand. More than
    1000 papers by Austrian authors were published open access at Springer in the
    first year alone. The working group &quot;Springer Compact Evaluierung&quot; made
    the data for these articles available via the platform OpenAPC and would like
    to use this opportunity to give a short account of what this publishing agreement
    actually entails and the working group intends to do.'
author:
- first_name: Magdalena
  full_name: Andrae, Magdalena
  last_name: Andrae
- first_name: Márton
  full_name: Villányi, Márton
  id: 3FFCCD3A-F248-11E8-B48F-1D18A9856A87
  last_name: Villányi
  orcid: 0000-0001-8126-0426
citation:
  ama: Andrae M, Villányi M. Der Springer Compact-Deal – Ein erster Einblick in die
    Evaluierung einer Offsetting-Vereinbarung. <i>Mitteilungen der Vereinigung Österreichischer
    Bibliothekarinnen und Bibliothekare</i>. 2017;70(2):274-280. doi:<a href="https://doi.org/10.31263/voebm.v70i2.1898">10.31263/voebm.v70i2.1898</a>
  apa: Andrae, M., &#38; Villányi, M. (2017). Der Springer Compact-Deal – Ein erster
    Einblick in die Evaluierung einer Offsetting-Vereinbarung. <i>Mitteilungen Der
    Vereinigung Österreichischer Bibliothekarinnen Und Bibliothekare</i>. VÖB. <a
    href="https://doi.org/10.31263/voebm.v70i2.1898">https://doi.org/10.31263/voebm.v70i2.1898</a>
  chicago: Andrae, Magdalena, and Márton Villányi. “Der Springer Compact-Deal – Ein
    Erster Einblick in Die Evaluierung Einer Offsetting-Vereinbarung.” <i>Mitteilungen
    Der Vereinigung Österreichischer Bibliothekarinnen Und Bibliothekare</i>. VÖB,
    2017. <a href="https://doi.org/10.31263/voebm.v70i2.1898">https://doi.org/10.31263/voebm.v70i2.1898</a>.
  ieee: M. Andrae and M. Villányi, “Der Springer Compact-Deal – Ein erster Einblick
    in die Evaluierung einer Offsetting-Vereinbarung,” <i>Mitteilungen der Vereinigung
    Österreichischer Bibliothekarinnen und Bibliothekare</i>, vol. 70, no. 2. VÖB,
    pp. 274–280, 2017.
  ista: Andrae M, Villányi M. 2017. Der Springer Compact-Deal – Ein erster Einblick
    in die Evaluierung einer Offsetting-Vereinbarung. Mitteilungen der Vereinigung
    Österreichischer Bibliothekarinnen und Bibliothekare. 70(2), 274–280.
  mla: Andrae, Magdalena, and Márton Villányi. “Der Springer Compact-Deal – Ein Erster
    Einblick in Die Evaluierung Einer Offsetting-Vereinbarung.” <i>Mitteilungen Der
    Vereinigung Österreichischer Bibliothekarinnen Und Bibliothekare</i>, vol. 70,
    no. 2, VÖB, 2017, pp. 274–80, doi:<a href="https://doi.org/10.31263/voebm.v70i2.1898">10.31263/voebm.v70i2.1898</a>.
  short: M. Andrae, M. Villányi, Mitteilungen Der Vereinigung Österreichischer Bibliothekarinnen
    Und Bibliothekare 70 (2017) 274–280.
date_created: 2018-12-11T11:48:36Z
date_published: 2017-08-01T00:00:00Z
date_updated: 2021-01-12T08:16:45Z
day: '01'
ddc:
- '020'
department:
- _id: E-Lib
doi: 10.31263/voebm.v70i2.1898
file:
- access_level: open_access
  checksum: 558c18bcf5580d87dd371ec626d52075
  content_type: application/pdf
  creator: dernst
  date_created: 2019-01-18T13:39:26Z
  date_updated: 2020-07-14T12:48:09Z
  file_id: '5851'
  file_name: 2017_VOEB_Andrae.pdf
  file_size: 125065
  relation: main_file
file_date_updated: 2020-07-14T12:48:09Z
has_accepted_license: '1'
intvolume: '        70'
issue: '2'
language:
- iso: eng
month: '08'
oa: 1
oa_version: Published Version
page: 274 - 280
popular_science: '1'
publication: Mitteilungen der Vereinigung Österreichischer Bibliothekarinnen und Bibliothekare
publication_identifier:
  issn:
  - '10222588'
publication_status: published
publisher: VÖB
publist_id: '6843'
scopus_import: 1
status: public
title: Der Springer Compact-Deal – Ein erster Einblick in die Evaluierung einer Offsetting-Vereinbarung
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: 3E5EF7F0-F248-11E8-B48F-1D18A9856A87
volume: 70
year: '2017'
...
---
_id: '818'
abstract:
- lang: eng
  text: 'Antibiotics have diverse effects on bacteria, including massive changes in
    bacterial gene expression. Whereas the gene expression changes under many antibiotics
    have been measured, the temporal organization of these responses and their dependence
    on the bacterial growth rate are unclear. As described in Chapter 1, we quantified
    the temporal gene expression changes in the bacterium Escherichia coli in response
    to the sudden exposure to antibiotics using a fluorescent reporter library and
    a robotic system. Our data show temporally structured gene expression responses,
    with response times for individual genes ranging from tens of minutes to several
    hours. We observed that many stress response genes were activated in response
    to antibiotics. As certain stress responses cross-protect bacteria from other
    stressors, we then asked whether cellular responses to antibiotics have a similar
    protective role in Chapter 2. Indeed, we found that the trimethoprim-induced acid
    stress response protects bacteria from subsequent acid stress. We combined microfluidics
    with time-lapse imaging to monitor survival, intracellular pH, and acid stress
    response in single cells. This approach revealed that the variable expression
    of the acid resistance operon gadBC strongly correlates with single-cell survival
    time. Cells with higher gadBC expression following trimethoprim maintain higher
    intracellular pH and survive the acid stress longer. Overall, we provide a way
    to identify single-cell cross-protection between antibiotics and environmental
    stressors from temporal gene expression data, and show how antibiotics can increase
    bacterial fitness in changing environments. While gene expression changes to antibiotics
    show a clear temporal structure at the population-level, it is unclear whether
    this clear temporal order is followed by every single cell. Using dual-reporter
    strains described in Chapter 3, we measured gene expression dynamics of promoter
    pairs in the same cells using microfluidics and microscopy. Chapter 4 shows that
    the oxidative stress response and the DNA stress response showed little timing
    variability and a clear temporal order under the antibiotic nitrofurantoin. In
    contrast, the acid stress response under trimethoprim ran independently from all
    other activated response programs including the DNA stress response, which showed
    particularly high timing variability in this stress condition. In summary, this
    approach provides insight into the temporal organization of gene expression programs
    at the single-cell level and suggests dependencies between response programs and
    the underlying variability-introducing mechanisms. Altogether, this work advances
    our understanding of the diverse effects that antibiotics have on bacteria. These
    results were obtained by taking into account gene expression dynamics, which allowed
    us to identify general principles, molecular mechanisms, and dependencies between
    genes. Our findings may have implications for infectious disease treatments, and
    microbial communities in the human body and in nature. '
acknowledgement: 'First of all, I would like to express great gratitude to my PhD
  supervisor Tobias Bollenbach. Through his open and trusting attitude I had the freedom
  to explore different scientific directions during this project, and follow the research
  lines of my interest. I am thankful for constructive and often extensive discussions
  and his support and commitment during the different stages of my PhD. I want to
  thank my committee members, Călin Guet, Terry Hwa and Nassos Typas for their interest
  and their valuable input to this project. Special thanks to Nassos for career guidance,
  and for accepting me in his lab. A big thank you goes to the past, present and affiliated
  members of the Bollenbach group: Guillaume Chevereau, Marjon de Vos, Marta Lukačišinová,
  Veronika Bierbaum, Qi Qin, Marcin Zagórski, Martin Lukačišin, Andreas Angermayr,
  Bor Kavčič, Julia Tischler, Dilay Ayhan, Jaroslav Ferenc, and Georg Rieckh. I enjoyed
  working and discussing with you very much and I will miss our lengthy group meetings,
  our inspiring journal clubs, and our common lunches. Special thanks to Bor for great
  mental and professional support during the hard months of thesis writing, and to
  Marta for very creative times during the beginning of our PhDs. May the ‘Bacterial
  Survival Guide’ decorate the walls of IST forever! A great thanks to my friend and
  collaborator Georg Rieckh for his enthusiasm and for getting so involved in these
  projects, for his endurance and for his company throughout the years. Thanks to
  the FriSBi crowd at IST Austria for interesting meetings and discussions. In particular
  I want to thank Magdalena Steinrück, and Anna Andersson for inspiring exchange,
  and enjoyable time together. Thanks to everybody who contributed to the cover for
  Cell Systems: The constructive input from Tobias Bollenbach, Bor Kavčič, Georg Rieckh,
  Marta Lukačišinová, and Sebastian Nozzi, and the professional implementation by
  the graphic designer Martina Markus from the University of Cologne. Thanks to all
  my office mates in the first floor Bertalanffy building throughout the years: for
  ensuring a pleasant working atmosphere, and for your company! In general, I want
  to thank all the people that make IST such a great environment, with the many possibilities
  to shape our own social and research environment. I want to thank my family for
  all kind of practical support during the years, and my second family in Argentina
  for their enthusiasm. Thanks to my brother Bernhard and my sister Martina for being
  great siblings, and to Helena and Valentin for the joy you brought to my life. My
  deep gratitude goes to Sebastian Nozzi, for constant support, patience, love and
  for believing in me. '
alternative_title:
- ISTA Thesis
article_processing_charge: No
author:
- first_name: Karin
  full_name: Mitosch, Karin
  id: 39B66846-F248-11E8-B48F-1D18A9856A87
  last_name: Mitosch
citation:
  ama: Mitosch K. Timing, variability and cross-protection in bacteria – insights
    from dynamic gene expression responses to antibiotics. 2017. doi:<a href="https://doi.org/10.15479/AT:ISTA:th_862">10.15479/AT:ISTA:th_862</a>
  apa: Mitosch, K. (2017). <i>Timing, variability and cross-protection in bacteria
    – insights from dynamic gene expression responses to antibiotics</i>. Institute
    of Science and Technology Austria. <a href="https://doi.org/10.15479/AT:ISTA:th_862">https://doi.org/10.15479/AT:ISTA:th_862</a>
  chicago: Mitosch, Karin. “Timing, Variability and Cross-Protection in Bacteria –
    Insights from Dynamic Gene Expression Responses to Antibiotics.” Institute of
    Science and Technology Austria, 2017. <a href="https://doi.org/10.15479/AT:ISTA:th_862">https://doi.org/10.15479/AT:ISTA:th_862</a>.
  ieee: K. Mitosch, “Timing, variability and cross-protection in bacteria – insights
    from dynamic gene expression responses to antibiotics,” Institute of Science and
    Technology Austria, 2017.
  ista: Mitosch K. 2017. Timing, variability and cross-protection in bacteria – insights
    from dynamic gene expression responses to antibiotics. Institute of Science and
    Technology Austria.
  mla: Mitosch, Karin. <i>Timing, Variability and Cross-Protection in Bacteria – Insights
    from Dynamic Gene Expression Responses to Antibiotics</i>. Institute of Science
    and Technology Austria, 2017, doi:<a href="https://doi.org/10.15479/AT:ISTA:th_862">10.15479/AT:ISTA:th_862</a>.
  short: K. Mitosch, Timing, Variability and Cross-Protection in Bacteria – Insights
    from Dynamic Gene Expression Responses to Antibiotics, Institute of Science and
    Technology Austria, 2017.
date_created: 2018-12-11T11:48:40Z
date_published: 2017-09-27T00:00:00Z
date_updated: 2023-09-07T12:00:26Z
day: '27'
ddc:
- '571'
- '579'
degree_awarded: PhD
department:
- _id: ToBo
doi: 10.15479/AT:ISTA:th_862
file:
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language:
- iso: eng
month: '09'
oa: 1
oa_version: Published Version
page: '113'
publication_identifier:
  issn:
  - 2663-337X
publication_status: published
publisher: Institute of Science and Technology Austria
publist_id: '6831'
pubrep_id: '862'
related_material:
  record:
  - id: '2001'
    relation: part_of_dissertation
    status: public
  - id: '666'
    relation: part_of_dissertation
    status: public
status: public
supervisor:
- first_name: Mark Tobias
  full_name: Bollenbach, Mark Tobias
  id: 3E6DB97A-F248-11E8-B48F-1D18A9856A87
  last_name: Bollenbach
  orcid: 0000-0003-4398-476X
title: Timing, variability and cross-protection in bacteria – insights from dynamic
  gene expression responses to antibiotics
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: dissertation
user_id: c635000d-4b10-11ee-a964-aac5a93f6ac1
year: '2017'
...
---
_id: '819'
abstract:
- lang: eng
  text: 'Contagious diseases must transmit from infectious to susceptible hosts in
    order to reproduce. Whilst vectored pathogens can rely on intermediaries to find
    new hosts for them, many infectious pathogens require close contact or direct
    interaction between hosts for transmission. Hence, this means that conspecifics
    are often the main source of infection for most animals and so, in theory, animals
    should avoid conspecifics to reduce their risk of infection. Of course, in reality
    animals must interact with one another, as a bare minimum, to mate. However, being
    social provides many additional benefits and group living has become a taxonomically
    diverse and widespread trait. How then do social animals overcome the issue of
    increased disease? Over the last few decades, the social insects (ants, termites
    and some bees and wasps) have become a model system for studying disease in social
    animals. On paper, a social insect colony should be particularly susceptible to
    disease, given that they often contain thousands of potential hosts that are closely
    related and frequently interact, as well as exhibiting stable environmental conditions
    that encourage microbial growth. Yet, disease outbreaks appear to be rare and
    attempts to eradicate pest species using pathogens have failed time and again.
    Evolutionary biologists investigating this observation have discovered that the
    reduced disease susceptibility in social insects is, in part, due to collectively
    performed disease defences of the workers. These defences act like a “social immune
    system” for the colony, resulting in a per capita decrease in disease, termed
    social immunity. Our understanding of social immunity, and its importance in relation
    to the immunological defences of each insect, continues to grow, but there remain
    many open questions. In this thesis I have studied disease defence in garden ants.
    In the first data chapter, I use the invasive garden ant, Lasius neglectus, to
    investigate how colonies mitigate lethal infections and prevent them from spreading
    systemically. I find that ants have evolved ‘destructive disinfection’ – a behaviour
    that uses endogenously produced acidic poison to kill diseased brood and to prevent
    the pathogen from replicating. In the second experimental chapter, I continue
    to study the use of poison in invasive garden ant colonies, finding that it is
    sprayed prophylactically within the nest. However, this spraying has negative
    effects on developing pupae when they have had their cocoons artificially removed.
    Hence, I suggest that acidic nest sanitation may be maintaining larval cocoon
    spinning in this species. In the next experimental chapter, I investigated how
    colony founding black garden ant queens (Lasius niger) prevent disease when a
    co-foundress dies. I show that ant queens prophylactically perform undertaking
    behaviours, similar to those performed by the workers in mature nests. When a
    co-foundress was infected, these undertaking behaviours improved the survival
    of the healthy queen. In the final data chapter, I explored how immunocompetence
    (measured as antifungal activity) changes as incipient black garden ant colonies
    grow and mature, from the solitary queen phase to colonies with several hundred
    workers. Queen and worker antifungal activity varied throughout this time period,
    but despite social immunity, did not decrease as colonies matured. In addition
    to the above data chapters, this thesis includes two co-authored reviews. In the
    first, we examine the state of the art in the field of social immunity and how
    it might develop in the future. In the second, we identify several challenges
    and open questions in the study of disease defence in animals. We highlight how
    social insects offer a unique model to tackle some of these problems, as disease
    defence can be studied from the cell to the society. '
acknowledgement: "ERC FP7 programme (grant agreement no. 240371)\r\nI have been supremely
  spoilt to work in a lab with such good resources and I must thank the wonderful
  Cremer group technicians, Anna, Barbara, Eva and Florian, for all of their help
  and keeping the lab up and running. You guys will probably be the most missed once
  I realise just how much work you have been saving me! For the same reason, I must
  say a big Dzi ę kuj ę Ci to Wonder Woman Wanda, for her tireless efforts feeding
  my colonies and cranking out thousands of petri dishes and sugar tubes. Again, you
  will be sorely missed now that I will have to take this task on myself. Of course,
  I will be eternally indebted to Prof. Sylvia Cremer for taking me under her wing
  and being a constant source of guidance and inspiration. You have given me the perfect
  balance of independence and supervision. I cannot thank you enough for creating
  such a great working environment and allowing me the freedom to follow my own research
  questions. I have had so many exceptional opportunities – attending and presenting
  at conferences all over the world, inviting me to write the ARE with you, going
  to workshops in Panama and Switzerland, and even organising our own PhD course –
  that I often think I must have had the best PhD in the world. You have taught me
  so much and made me a scientist. I sincerely hope we get the chance to work together
  again in the future. Thank you for everything. I must also thank my PhD Committee,
  Daria Siekhaus and Jacobus “Koos” Boomsma, for being very supportive throughout
  the duration of my PhD. "
alternative_title:
- ISTA Thesis
article_processing_charge: No
author:
- first_name: Christopher
  full_name: Pull, Christopher
  id: 3C7F4840-F248-11E8-B48F-1D18A9856A87
  last_name: Pull
  orcid: 0000-0003-1122-3982
citation:
  ama: Pull C. Disease defence in garden ants. 2017. doi:<a href="https://doi.org/10.15479/AT:ISTA:th_861">10.15479/AT:ISTA:th_861</a>
  apa: Pull, C. (2017). <i>Disease defence in garden ants</i>. Institute of Science
    and Technology Austria. <a href="https://doi.org/10.15479/AT:ISTA:th_861">https://doi.org/10.15479/AT:ISTA:th_861</a>
  chicago: Pull, Christopher. “Disease Defence in Garden Ants.” Institute of Science
    and Technology Austria, 2017. <a href="https://doi.org/10.15479/AT:ISTA:th_861">https://doi.org/10.15479/AT:ISTA:th_861</a>.
  ieee: C. Pull, “Disease defence in garden ants,” Institute of Science and Technology
    Austria, 2017.
  ista: Pull C. 2017. Disease defence in garden ants. Institute of Science and Technology
    Austria.
  mla: Pull, Christopher. <i>Disease Defence in Garden Ants</i>. Institute of Science
    and Technology Austria, 2017, doi:<a href="https://doi.org/10.15479/AT:ISTA:th_861">10.15479/AT:ISTA:th_861</a>.
  short: C. Pull, Disease Defence in Garden Ants, Institute of Science and Technology
    Austria, 2017.
date_created: 2018-12-11T11:48:40Z
date_published: 2017-09-26T00:00:00Z
date_updated: 2023-09-28T11:31:32Z
day: '26'
ddc:
- '576'
- '577'
- '578'
- '579'
- '590'
- '592'
degree_awarded: PhD
department:
- _id: SyCr
doi: 10.15479/AT:ISTA:th_861
file:
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  date_updated: 2020-07-14T12:48:09Z
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  file_name: 2017_Thesis_Pull.docx
  file_size: 18580400
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  file_name: 2017_Thesis_Pull.pdf
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file_date_updated: 2020-07-14T12:48:09Z
has_accepted_license: '1'
language:
- iso: eng
month: '09'
oa: 1
oa_version: Published Version
page: '122'
publication_identifier:
  issn:
  - 2663-337X
publication_status: published
publisher: Institute of Science and Technology Austria
publist_id: '6830'
pubrep_id: '861'
related_material:
  record:
  - id: '616'
    relation: part_of_dissertation
    status: public
  - id: '806'
    relation: part_of_dissertation
    status: public
  - id: '734'
    relation: part_of_dissertation
    status: public
  - id: '732'
    relation: part_of_dissertation
    status: public
status: public
supervisor:
- first_name: Sylvia M
  full_name: Cremer, Sylvia M
  id: 2F64EC8C-F248-11E8-B48F-1D18A9856A87
  last_name: Cremer
  orcid: 0000-0002-2193-3868
title: Disease defence in garden ants
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: dissertation
user_id: c635000d-4b10-11ee-a964-aac5a93f6ac1
year: '2017'
...
---
_id: '1528'
abstract:
- lang: eng
  text: 'We consider N×N Hermitian random matrices H consisting of blocks of size
    M≥N6/7. The matrix elements are i.i.d. within the blocks, close to a Gaussian
    in the four moment matching sense, but their distribution varies from block to
    block to form a block-band structure, with an essential band width M. We show
    that the entries of the Green’s function G(z)=(H−z)−1 satisfy the local semicircle
    law with spectral parameter z=E+iη down to the real axis for any η≫N−1, using
    a combination of the supersymmetry method inspired by Shcherbina (J Stat Phys
    155(3): 466–499, 2014) and the Green’s function comparison strategy. Previous
    estimates were valid only for η≫M−1. The new estimate also implies that the eigenvectors
    in the middle of the spectrum are fully delocalized.'
acknowledgement: "Z. Bao was supported by ERC Advanced Grant RANMAT No. 338804; L.
  Erdős was partially supported by ERC Advanced Grant RANMAT No. 338804.\r\nOpen access
  funding provided by Institute of Science and Technology (IST Austria). The authors
  are very grateful to the anonymous referees for careful reading and valuable comments,
  which helped to improve the organization."
article_processing_charge: Yes (via OA deal)
article_type: original
author:
- first_name: Zhigang
  full_name: Bao, Zhigang
  id: 442E6A6C-F248-11E8-B48F-1D18A9856A87
  last_name: Bao
  orcid: 0000-0003-3036-1475
- first_name: László
  full_name: Erdös, László
  id: 4DBD5372-F248-11E8-B48F-1D18A9856A87
  last_name: Erdös
  orcid: 0000-0001-5366-9603
citation:
  ama: Bao Z, Erdös L. Delocalization for a class of random block band matrices. <i>Probability
    Theory and Related Fields</i>. 2017;167(3-4):673-776. doi:<a href="https://doi.org/10.1007/s00440-015-0692-y">10.1007/s00440-015-0692-y</a>
  apa: Bao, Z., &#38; Erdös, L. (2017). Delocalization for a class of random block
    band matrices. <i>Probability Theory and Related Fields</i>. Springer. <a href="https://doi.org/10.1007/s00440-015-0692-y">https://doi.org/10.1007/s00440-015-0692-y</a>
  chicago: Bao, Zhigang, and László Erdös. “Delocalization for a Class of Random Block
    Band Matrices.” <i>Probability Theory and Related Fields</i>. Springer, 2017.
    <a href="https://doi.org/10.1007/s00440-015-0692-y">https://doi.org/10.1007/s00440-015-0692-y</a>.
  ieee: Z. Bao and L. Erdös, “Delocalization for a class of random block band matrices,”
    <i>Probability Theory and Related Fields</i>, vol. 167, no. 3–4. Springer, pp.
    673–776, 2017.
  ista: Bao Z, Erdös L. 2017. Delocalization for a class of random block band matrices.
    Probability Theory and Related Fields. 167(3–4), 673–776.
  mla: Bao, Zhigang, and László Erdös. “Delocalization for a Class of Random Block
    Band Matrices.” <i>Probability Theory and Related Fields</i>, vol. 167, no. 3–4,
    Springer, 2017, pp. 673–776, doi:<a href="https://doi.org/10.1007/s00440-015-0692-y">10.1007/s00440-015-0692-y</a>.
  short: Z. Bao, L. Erdös, Probability Theory and Related Fields 167 (2017) 673–776.
date_created: 2018-12-11T11:52:32Z
date_published: 2017-04-01T00:00:00Z
date_updated: 2023-09-20T09:42:12Z
day: '01'
ddc:
- '530'
department:
- _id: LaEr
doi: 10.1007/s00440-015-0692-y
ec_funded: 1
external_id:
  isi:
  - '000398842700004'
file:
- access_level: open_access
  checksum: 67afa85ff1e220cbc1f9f477a828513c
  content_type: application/pdf
  creator: system
  date_created: 2018-12-12T10:08:05Z
  date_updated: 2020-07-14T12:45:00Z
  file_id: '4665'
  file_name: IST-2016-489-v1+1_s00440-015-0692-y.pdf
  file_size: 1615755
  relation: main_file
file_date_updated: 2020-07-14T12:45:00Z
has_accepted_license: '1'
intvolume: '       167'
isi: 1
issue: 3-4
language:
- iso: eng
month: '04'
oa: 1
oa_version: Published Version
page: 673 - 776
project:
- _id: 258DCDE6-B435-11E9-9278-68D0E5697425
  call_identifier: FP7
  grant_number: '338804'
  name: Random matrices, universality and disordered quantum systems
publication: Probability Theory and Related Fields
publication_identifier:
  issn:
  - '01788051'
publication_status: published
publisher: Springer
publist_id: '5644'
pubrep_id: '489'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Delocalization for a class of random block band matrices
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: c635000d-4b10-11ee-a964-aac5a93f6ac1
volume: 167
year: '2017'
...
---
_id: '2016'
abstract:
- lang: eng
  text: The Ising model is one of the simplest and most famous models of interacting
    systems. It was originally proposed to model ferromagnetic interactions in statistical
    physics and is now widely used to model spatial processes in many areas such as
    ecology, sociology, and genetics, usually without testing its goodness-of-fit.
    Here, we propose an exact goodness-of-fit test for the finite-lattice Ising model.
    The theory of Markov bases has been developed in algebraic statistics for exact
    goodness-of-fit testing using a Monte Carlo approach. However, this beautiful
    theory has fallen short of its promise for applications, because finding a Markov
    basis is usually computationally intractable. We develop a Monte Carlo method
    for exact goodness-of-fit testing for the Ising model which avoids computing a
    Markov basis and also leads to a better connectivity of the Markov chain and hence
    to a faster convergence. We show how this method can be applied to analyze the
    spatial organization of receptors on the cell membrane.
article_processing_charge: No
arxiv: 1
author:
- first_name: Abraham
  full_name: Martin Del Campo Sanchez, Abraham
  last_name: Martin Del Campo Sanchez
- first_name: Sarah A
  full_name: Cepeda Humerez, Sarah A
  id: 3DEE19A4-F248-11E8-B48F-1D18A9856A87
  last_name: Cepeda Humerez
- first_name: Caroline
  full_name: Uhler, Caroline
  id: 49ADD78E-F248-11E8-B48F-1D18A9856A87
  last_name: Uhler
  orcid: 0000-0002-7008-0216
citation:
  ama: Martin Del Campo Sanchez A, Cepeda Humerez SA, Uhler C. Exact goodness-of-fit
    testing for the Ising model. <i>Scandinavian Journal of Statistics</i>. 2017;44(2):285-306.
    doi:<a href="https://doi.org/10.1111/sjos.12251">10.1111/sjos.12251</a>
  apa: Martin Del Campo Sanchez, A., Cepeda Humerez, S. A., &#38; Uhler, C. (2017).
    Exact goodness-of-fit testing for the Ising model. <i>Scandinavian Journal of
    Statistics</i>. Wiley-Blackwell. <a href="https://doi.org/10.1111/sjos.12251">https://doi.org/10.1111/sjos.12251</a>
  chicago: Martin Del Campo Sanchez, Abraham, Sarah A Cepeda Humerez, and Caroline
    Uhler. “Exact Goodness-of-Fit Testing for the Ising Model.” <i>Scandinavian Journal
    of Statistics</i>. Wiley-Blackwell, 2017. <a href="https://doi.org/10.1111/sjos.12251">https://doi.org/10.1111/sjos.12251</a>.
  ieee: A. Martin Del Campo Sanchez, S. A. Cepeda Humerez, and C. Uhler, “Exact goodness-of-fit
    testing for the Ising model,” <i>Scandinavian Journal of Statistics</i>, vol.
    44, no. 2. Wiley-Blackwell, pp. 285–306, 2017.
  ista: Martin Del Campo Sanchez A, Cepeda Humerez SA, Uhler C. 2017. Exact goodness-of-fit
    testing for the Ising model. Scandinavian Journal of Statistics. 44(2), 285–306.
  mla: Martin Del Campo Sanchez, Abraham, et al. “Exact Goodness-of-Fit Testing for
    the Ising Model.” <i>Scandinavian Journal of Statistics</i>, vol. 44, no. 2, Wiley-Blackwell,
    2017, pp. 285–306, doi:<a href="https://doi.org/10.1111/sjos.12251">10.1111/sjos.12251</a>.
  short: A. Martin Del Campo Sanchez, S.A. Cepeda Humerez, C. Uhler, Scandinavian
    Journal of Statistics 44 (2017) 285–306.
date_created: 2018-12-11T11:55:13Z
date_published: 2017-06-01T00:00:00Z
date_updated: 2023-09-19T15:13:27Z
day: '01'
department:
- _id: GaTk
doi: 10.1111/sjos.12251
external_id:
  arxiv:
  - '1410.1242'
  isi:
  - '000400985000001'
intvolume: '        44'
isi: 1
issue: '2'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: http://arxiv.org/abs/1410.1242
month: '06'
oa: 1
oa_version: Preprint
page: 285 - 306
publication: Scandinavian Journal of Statistics
publication_identifier:
  issn:
  - '03036898'
publication_status: published
publisher: Wiley-Blackwell
publist_id: '5060'
quality_controlled: '1'
related_material:
  record:
  - id: '6473'
    relation: part_of_dissertation
    status: public
scopus_import: '1'
status: public
title: Exact goodness-of-fit testing for the Ising model
type: journal_article
user_id: c635000d-4b10-11ee-a964-aac5a93f6ac1
volume: 44
year: '2017'
...
---
_id: '202'
abstract:
- lang: eng
  text: 'Restriction-modification (RM) represents the simplest and possibly the most
    widespread mechanism of self/non-self discrimination in nature. In order to provide
    bacteria with immunity against bacteriophages and other parasitic genetic elements,
    RM systems rely on a balance between two enzymes: the restriction enzyme, which
    cleaves non-self DNA at specific restriction sites, and the modification enzyme,
    which tags the host’s DNA as self and thus protects it from cleavage. In this
    thesis, I use population and single-cell level experiments in combination with
    mathematical modeling to study different aspects of the interplay between RM systems,
    bacteria and bacteriophages. First, I analyze how mutations in phage restriction
    sites affect the probability of phage escape – an inherently stochastic process,
    during which phages accidently get modified instead of restricted. Next, I use
    single-cell experiments to show that RM systems can, with a low probability, attack
    the genome of their bacterial host and that this primitive form of autoimmunity
    leads to a tradeoff between the evolutionary cost and benefit of RM systems. Finally,
    I investigate the nature of interactions between bacteria, RM systems and temperate
    bacteriophages to find that, as a consequence of phage escape and its impact on
    population dynamics, RM systems can promote acquisition of symbiotic bacteriophages,
    rather than limit it. The results presented here uncover new fundamental biological
    properties of RM systems and highlight their importance in the ecology and evolution
    of bacteria, bacteriophages and their interactions.'
acknowledgement: "During my PhD studies, I received help from many people, all of
  which unfortunately cannot be listed here. I thank them deeply and hope that I never
  made them regret their kindness.\r\nI would like to express my deepest gratitude
  to Călin Guet, who went far beyond his responsibilities as an advisor and was to
  me also a great mentor and a friend. Călin never questioned my potential or lacked
  compassion and I cannot thank him enough for cultivating in me an independent scientist.
  I was amazed by his ability to recognize the most fascinating scientific problems
  in objects of study that others would find mundane. I hope I adopted at least a
  fraction of this ability.\r\nI will be forever grateful to Bruce Levin for all his
  support and especially for giving me the best possible example of how one can practice
  excellent science with humor and style. Working with Bruce was a true privilege.\r\nI
  thank Jonathan Bollback and Gašper Tkačik for serving in my PhD committee and the
  Austrian Academy of Science for funding my PhD research via the DOC fellowship.\r\nI
  thank all our lab members: Tobias Bergmiller for his guidance, especially in the
  first years of my research, and for being a good friend throughout; Remy Chait for
  staying in the lab at unreasonable hours and for the good laughs at bad jokes we
  shared; Anna Staron for supportively listening to my whines whenever I had to run
  a gel; Magdalena Steinrück for her pioneering work in the lab; Kathrin Tomasek for
  keeping the entropic forces in check and for her FACS virtuosity; Isabella Tomanek
  for always being nice to me, no matter how much bench space I took from her.\r\nI
  thank all my collaborators: Reiko Okura and Yuichi Wakamoto for performing and analyzing
  the microfluidic experiments; Long Qian and Edo Kussell for their bioinformatics
  analysis; Dominik Refardt for the λ kan phage; Moritz for his help with the mathematical
  modeling. I thank Fabienne Jesse for her tireless editorial work on all our manuscripts.\r\nFinally,
  I would like to thank my family and especially my wife Edita, who sacrificed a lot
  so that I can pursue my goals and dreams.\r\n"
alternative_title:
- ISTA Thesis
article_processing_charge: No
author:
- first_name: Maros
  full_name: Pleska, Maros
  id: 4569785E-F248-11E8-B48F-1D18A9856A87
  last_name: Pleska
  orcid: 0000-0001-7460-7479
citation:
  ama: Pleska M. Biology of restriction-modification systems at the single-cell and
    population level. 2017. doi:<a href="https://doi.org/10.15479/AT:ISTA:th_916">10.15479/AT:ISTA:th_916</a>
  apa: Pleska, M. (2017). <i>Biology of restriction-modification systems at the single-cell
    and population level</i>. Institute of Science and Technology Austria. <a href="https://doi.org/10.15479/AT:ISTA:th_916">https://doi.org/10.15479/AT:ISTA:th_916</a>
  chicago: Pleska, Maros. “Biology of Restriction-Modification Systems at the Single-Cell
    and Population Level.” Institute of Science and Technology Austria, 2017. <a href="https://doi.org/10.15479/AT:ISTA:th_916">https://doi.org/10.15479/AT:ISTA:th_916</a>.
  ieee: M. Pleska, “Biology of restriction-modification systems at the single-cell
    and population level,” Institute of Science and Technology Austria, 2017.
  ista: Pleska M. 2017. Biology of restriction-modification systems at the single-cell
    and population level. Institute of Science and Technology Austria.
  mla: Pleska, Maros. <i>Biology of Restriction-Modification Systems at the Single-Cell
    and Population Level</i>. Institute of Science and Technology Austria, 2017, doi:<a
    href="https://doi.org/10.15479/AT:ISTA:th_916">10.15479/AT:ISTA:th_916</a>.
  short: M. Pleska, Biology of Restriction-Modification Systems at the Single-Cell
    and Population Level, Institute of Science and Technology Austria, 2017.
date_created: 2018-12-11T11:45:10Z
date_published: 2017-10-01T00:00:00Z
date_updated: 2023-09-15T12:04:56Z
day: '01'
ddc:
- '576'
- '579'
degree_awarded: PhD
department:
- _id: CaGu
doi: 10.15479/AT:ISTA:th_916
file:
- access_level: open_access
  checksum: 33cfb59674e91f82e3738396d3fb3776
  content_type: application/pdf
  creator: system
  date_created: 2018-12-12T10:08:48Z
  date_updated: 2020-07-14T12:45:24Z
  file_id: '4710'
  file_name: IST-2018-916-v1+3_2017_Pleska_Maros_Thesis.pdf
  file_size: 18569590
  relation: main_file
- access_level: closed
  checksum: dcc239968decb233e7f98cf1083d8c26
  content_type: application/vnd.openxmlformats-officedocument.wordprocessingml.document
  creator: dernst
  date_created: 2019-04-05T08:33:14Z
  date_updated: 2020-07-14T12:45:24Z
  file_id: '6204'
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file_date_updated: 2020-07-14T12:45:24Z
has_accepted_license: '1'
language:
- iso: eng
month: '10'
oa: 1
oa_version: Published Version
page: '126'
project:
- _id: 251D65D8-B435-11E9-9278-68D0E5697425
  grant_number: '24210'
  name: Effects of Stochasticity on the Function of Restriction-Modi cation Systems
    at the Single-Cell Level (DOC Fellowship)
publication_identifier:
  issn:
  - 2663-337X
publication_status: published
publisher: Institute of Science and Technology Austria
publist_id: '7711'
pubrep_id: '916'
related_material:
  record:
  - id: '1243'
    relation: part_of_dissertation
    status: public
  - id: '561'
    relation: part_of_dissertation
    status: public
  - id: '457'
    relation: part_of_dissertation
    status: public
status: public
supervisor:
- first_name: Calin C
  full_name: Guet, Calin C
  id: 47F8433E-F248-11E8-B48F-1D18A9856A87
  last_name: Guet
  orcid: 0000-0001-6220-2052
title: Biology of restriction-modification systems at the single-cell and population
  level
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: dissertation
user_id: c635000d-4b10-11ee-a964-aac5a93f6ac1
year: '2017'
...
---
_id: '1336'
abstract:
- lang: eng
  text: Evolutionary algorithms (EAs) form a popular optimisation paradigm inspired
    by natural evolution. In recent years the field of evolutionary computation has
    developed a rigorous analytical theory to analyse the runtimes of EAs on many
    illustrative problems. Here we apply this theory to a simple model of natural
    evolution. In the Strong Selection Weak Mutation (SSWM) evolutionary regime the
    time between occurrences of new mutations is much longer than the time it takes
    for a mutated genotype to take over the population. In this situation, the population
    only contains copies of one genotype and evolution can be modelled as a stochastic
    process evolving one genotype by means of mutation and selection between the resident
    and the mutated genotype. The probability of accepting the mutated genotype then
    depends on the change in fitness. We study this process, SSWM, from an algorithmic
    perspective, quantifying its expected optimisation time for various parameters
    and investigating differences to a similar evolutionary algorithm, the well-known
    (1+1) EA. We show that SSWM can have a moderate advantage over the (1+1) EA at
    crossing fitness valleys and study an example where SSWM outperforms the (1+1)
    EA by taking advantage of information on the fitness gradient.
article_processing_charge: No
author:
- first_name: Tiago
  full_name: Paixao, Tiago
  id: 2C5658E6-F248-11E8-B48F-1D18A9856A87
  last_name: Paixao
  orcid: 0000-0003-2361-3953
- first_name: Jorge
  full_name: Pérez Heredia, Jorge
  last_name: Pérez Heredia
- first_name: Dirk
  full_name: Sudholt, Dirk
  last_name: Sudholt
- first_name: Barbora
  full_name: Trubenova, Barbora
  id: 42302D54-F248-11E8-B48F-1D18A9856A87
  last_name: Trubenova
  orcid: 0000-0002-6873-2967
citation:
  ama: Paixao T, Pérez Heredia J, Sudholt D, Trubenova B. Towards a runtime comparison
    of natural and artificial evolution. <i>Algorithmica</i>. 2017;78(2):681-713.
    doi:<a href="https://doi.org/10.1007/s00453-016-0212-1">10.1007/s00453-016-0212-1</a>
  apa: Paixao, T., Pérez Heredia, J., Sudholt, D., &#38; Trubenova, B. (2017). Towards
    a runtime comparison of natural and artificial evolution. <i>Algorithmica</i>.
    Springer. <a href="https://doi.org/10.1007/s00453-016-0212-1">https://doi.org/10.1007/s00453-016-0212-1</a>
  chicago: Paixao, Tiago, Jorge Pérez Heredia, Dirk Sudholt, and Barbora Trubenova.
    “Towards a Runtime Comparison of Natural and Artificial Evolution.” <i>Algorithmica</i>.
    Springer, 2017. <a href="https://doi.org/10.1007/s00453-016-0212-1">https://doi.org/10.1007/s00453-016-0212-1</a>.
  ieee: T. Paixao, J. Pérez Heredia, D. Sudholt, and B. Trubenova, “Towards a runtime
    comparison of natural and artificial evolution,” <i>Algorithmica</i>, vol. 78,
    no. 2. Springer, pp. 681–713, 2017.
  ista: Paixao T, Pérez Heredia J, Sudholt D, Trubenova B. 2017. Towards a runtime
    comparison of natural and artificial evolution. Algorithmica. 78(2), 681–713.
  mla: Paixao, Tiago, et al. “Towards a Runtime Comparison of Natural and Artificial
    Evolution.” <i>Algorithmica</i>, vol. 78, no. 2, Springer, 2017, pp. 681–713,
    doi:<a href="https://doi.org/10.1007/s00453-016-0212-1">10.1007/s00453-016-0212-1</a>.
  short: T. Paixao, J. Pérez Heredia, D. Sudholt, B. Trubenova, Algorithmica 78 (2017)
    681–713.
date_created: 2018-12-11T11:51:27Z
date_published: 2017-06-01T00:00:00Z
date_updated: 2023-09-20T11:14:42Z
day: '01'
ddc:
- '576'
department:
- _id: NiBa
- _id: CaGu
doi: 10.1007/s00453-016-0212-1
ec_funded: 1
external_id:
  isi:
  - '000400379500013'
file:
- access_level: open_access
  checksum: 7873f665a0c598ac747c908f34cb14b9
  content_type: application/pdf
  creator: system
  date_created: 2018-12-12T10:10:19Z
  date_updated: 2020-07-14T12:44:44Z
  file_id: '4805'
  file_name: IST-2016-658-v1+1_s00453-016-0212-1.pdf
  file_size: 710206
  relation: main_file
file_date_updated: 2020-07-14T12:44:44Z
has_accepted_license: '1'
intvolume: '        78'
isi: 1
issue: '2'
language:
- iso: eng
month: '06'
oa: 1
oa_version: Published Version
page: 681 - 713
project:
- _id: 25B1EC9E-B435-11E9-9278-68D0E5697425
  call_identifier: FP7
  grant_number: '618091'
  name: Speed of Adaptation in Population Genetics and Evolutionary Computation
publication: Algorithmica
publication_identifier:
  issn:
  - '01784617'
publication_status: published
publisher: Springer
publist_id: '5931'
pubrep_id: '658'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Towards a runtime comparison of natural and artificial evolution
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: c635000d-4b10-11ee-a964-aac5a93f6ac1
volume: 78
year: '2017'
...
---
_id: '1337'
abstract:
- lang: eng
  text: We consider the local eigenvalue distribution of large self-adjoint N×N random
    matrices H=H∗ with centered independent entries. In contrast to previous works
    the matrix of variances sij=\mathbbmE|hij|2 is not assumed to be stochastic. Hence
    the density of states is not the Wigner semicircle law. Its possible shapes are
    described in the companion paper (Ajanki et al. in Quadratic Vector Equations
    on the Complex Upper Half Plane. arXiv:1506.05095). We show that as N grows, the
    resolvent, G(z)=(H−z)−1, converges to a diagonal matrix, diag(m(z)), where m(z)=(m1(z),…,mN(z))
    solves the vector equation −1/mi(z)=z+∑jsijmj(z) that has been analyzed in Ajanki
    et al. (Quadratic Vector Equations on the Complex Upper Half Plane. arXiv:1506.05095).
    We prove a local law down to the smallest spectral resolution scale, and bulk
    universality for both real symmetric and complex hermitian symmetry classes.
acknowledgement: 'Open access funding provided by Institute of Science and Technology
  (IST Austria).  '
article_processing_charge: Yes (via OA deal)
author:
- first_name: Oskari H
  full_name: Ajanki, Oskari H
  id: 36F2FB7E-F248-11E8-B48F-1D18A9856A87
  last_name: Ajanki
- first_name: László
  full_name: Erdös, László
  id: 4DBD5372-F248-11E8-B48F-1D18A9856A87
  last_name: Erdös
  orcid: 0000-0001-5366-9603
- first_name: Torben H
  full_name: Krüger, Torben H
  id: 3020C786-F248-11E8-B48F-1D18A9856A87
  last_name: Krüger
  orcid: 0000-0002-4821-3297
citation:
  ama: Ajanki OH, Erdös L, Krüger TH. Universality for general Wigner-type matrices.
    <i>Probability Theory and Related Fields</i>. 2017;169(3-4):667-727. doi:<a href="https://doi.org/10.1007/s00440-016-0740-2">10.1007/s00440-016-0740-2</a>
  apa: Ajanki, O. H., Erdös, L., &#38; Krüger, T. H. (2017). Universality for general
    Wigner-type matrices. <i>Probability Theory and Related Fields</i>. Springer.
    <a href="https://doi.org/10.1007/s00440-016-0740-2">https://doi.org/10.1007/s00440-016-0740-2</a>
  chicago: Ajanki, Oskari H, László Erdös, and Torben H Krüger. “Universality for
    General Wigner-Type Matrices.” <i>Probability Theory and Related Fields</i>. Springer,
    2017. <a href="https://doi.org/10.1007/s00440-016-0740-2">https://doi.org/10.1007/s00440-016-0740-2</a>.
  ieee: O. H. Ajanki, L. Erdös, and T. H. Krüger, “Universality for general Wigner-type
    matrices,” <i>Probability Theory and Related Fields</i>, vol. 169, no. 3–4. Springer,
    pp. 667–727, 2017.
  ista: Ajanki OH, Erdös L, Krüger TH. 2017. Universality for general Wigner-type
    matrices. Probability Theory and Related Fields. 169(3–4), 667–727.
  mla: Ajanki, Oskari H., et al. “Universality for General Wigner-Type Matrices.”
    <i>Probability Theory and Related Fields</i>, vol. 169, no. 3–4, Springer, 2017,
    pp. 667–727, doi:<a href="https://doi.org/10.1007/s00440-016-0740-2">10.1007/s00440-016-0740-2</a>.
  short: O.H. Ajanki, L. Erdös, T.H. Krüger, Probability Theory and Related Fields
    169 (2017) 667–727.
date_created: 2018-12-11T11:51:27Z
date_published: 2017-12-01T00:00:00Z
date_updated: 2023-09-20T11:14:17Z
day: '01'
ddc:
- '510'
- '530'
department:
- _id: LaEr
doi: 10.1007/s00440-016-0740-2
ec_funded: 1
external_id:
  isi:
  - '000414358400002'
file:
- access_level: open_access
  checksum: 29f5a72c3f91e408aeb9e78344973803
  content_type: application/pdf
  creator: system
  date_created: 2018-12-12T10:08:25Z
  date_updated: 2020-07-14T12:44:44Z
  file_id: '4686'
  file_name: IST-2017-657-v1+2_s00440-016-0740-2.pdf
  file_size: 988843
  relation: main_file
file_date_updated: 2020-07-14T12:44:44Z
has_accepted_license: '1'
intvolume: '       169'
isi: 1
issue: 3-4
language:
- iso: eng
month: '12'
oa: 1
oa_version: Published Version
page: 667 - 727
project:
- _id: 258DCDE6-B435-11E9-9278-68D0E5697425
  call_identifier: FP7
  grant_number: '338804'
  name: Random matrices, universality and disordered quantum systems
- _id: B67AFEDC-15C9-11EA-A837-991A96BB2854
  name: IST Austria Open Access Fund
publication: Probability Theory and Related Fields
publication_identifier:
  issn:
  - '01788051'
publication_status: published
publisher: Springer
publist_id: '5930'
pubrep_id: '657'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Universality for general Wigner-type matrices
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: c635000d-4b10-11ee-a964-aac5a93f6ac1
volume: 169
year: '2017'
...
