---
_id: '5673'
abstract:
- lang: eng
  text: Cell polarity, manifested by the localization of proteins to distinct polar
    plasma membrane domains, is a key prerequisite of multicellular life. In plants,
    PIN auxin transporters are prominent polarity markers crucial for a plethora of
    developmental processes. Cell polarity mechanisms in plants are distinct from
    other eukaryotes and still largely elusive. In particular, how the cell polarities
    are propagated and maintained following cell division remains unknown. Plant cytokinesis
    is orchestrated by the cell plate—a transient centrifugally growing endomembrane
    compartment ultimately forming the cross wall1. Trafficking of polar membrane
    proteins is typically redirected to the cell plate, and these will consequently
    have opposite polarity in at least one of the daughter cells2–5. Here, we provide
    mechanistic insights into post-cytokinetic re-establishment of cell polarity as
    manifested by the apical, polar localization of PIN2. We show that the apical
    domain is defined in a cell-intrinsic manner and that re-establishment of PIN2
    localization to this domain requires de novo protein secretion and endocytosis,
    but not basal-to-apical transcytosis. Furthermore, we identify a PINOID-related
    kinase WAG1, which phosphorylates PIN2 in vitro6 and is transcriptionally upregulated
    specifically in dividing cells, as a crucial regulator of post-cytokinetic PIN2
    polarity re-establishment.
article_processing_charge: No
author:
- first_name: Matous
  full_name: Glanc, Matous
  id: 1AE1EA24-02D0-11E9-9BAA-DAF4881429F2
  last_name: Glanc
  orcid: 0000-0003-0619-7783
- first_name: Matyas
  full_name: Fendrych, Matyas
  id: 43905548-F248-11E8-B48F-1D18A9856A87
  last_name: Fendrych
  orcid: 0000-0002-9767-8699
- first_name: Jirí
  full_name: Friml, Jirí
  id: 4159519E-F248-11E8-B48F-1D18A9856A87
  last_name: Friml
  orcid: 0000-0002-8302-7596
citation:
  ama: Glanc M, Fendrych M, Friml J. Mechanistic framework for cell-intrinsic re-establishment
    of PIN2 polarity after cell division. <i>Nature Plants</i>. 2018;4(12):1082-1088.
    doi:<a href="https://doi.org/10.1038/s41477-018-0318-3">10.1038/s41477-018-0318-3</a>
  apa: Glanc, M., Fendrych, M., &#38; Friml, J. (2018). Mechanistic framework for
    cell-intrinsic re-establishment of PIN2 polarity after cell division. <i>Nature
    Plants</i>. Nature Research. <a href="https://doi.org/10.1038/s41477-018-0318-3">https://doi.org/10.1038/s41477-018-0318-3</a>
  chicago: Glanc, Matous, Matyas Fendrych, and Jiří Friml. “Mechanistic Framework
    for Cell-Intrinsic Re-Establishment of PIN2 Polarity after Cell Division.” <i>Nature
    Plants</i>. Nature Research, 2018. <a href="https://doi.org/10.1038/s41477-018-0318-3">https://doi.org/10.1038/s41477-018-0318-3</a>.
  ieee: M. Glanc, M. Fendrych, and J. Friml, “Mechanistic framework for cell-intrinsic
    re-establishment of PIN2 polarity after cell division,” <i>Nature Plants</i>,
    vol. 4, no. 12. Nature Research, pp. 1082–1088, 2018.
  ista: Glanc M, Fendrych M, Friml J. 2018. Mechanistic framework for cell-intrinsic
    re-establishment of PIN2 polarity after cell division. Nature Plants. 4(12), 1082–1088.
  mla: Glanc, Matous, et al. “Mechanistic Framework for Cell-Intrinsic Re-Establishment
    of PIN2 Polarity after Cell Division.” <i>Nature Plants</i>, vol. 4, no. 12, Nature
    Research, 2018, pp. 1082–88, doi:<a href="https://doi.org/10.1038/s41477-018-0318-3">10.1038/s41477-018-0318-3</a>.
  short: M. Glanc, M. Fendrych, J. Friml, Nature Plants 4 (2018) 1082–1088.
date_created: 2018-12-16T22:59:18Z
date_published: 2018-12-03T00:00:00Z
date_updated: 2023-10-17T12:19:28Z
day: '03'
department:
- _id: JiFr
doi: 10.1038/s41477-018-0318-3
ec_funded: 1
external_id:
  isi:
  - '000454576600017'
  pmid:
  - '30518833'
intvolume: '         4'
isi: 1
issue: '12'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://www.ncbi.nlm.nih.gov/pubmed/30518833
month: '12'
oa: 1
oa_version: Submitted Version
page: 1082-1088
pmid: 1
project:
- _id: 261099A6-B435-11E9-9278-68D0E5697425
  call_identifier: H2020
  grant_number: '742985'
  name: Tracing Evolution of Auxin Transport and Polarity in Plants
publication: Nature Plants
publication_identifier:
  issn:
  - 2055-0278
publication_status: published
publisher: Nature Research
quality_controlled: '1'
scopus_import: '1'
status: public
title: Mechanistic framework for cell-intrinsic re-establishment of PIN2 polarity
  after cell division
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 4
year: '2018'
...
---
_id: '5676'
abstract:
- lang: eng
  text: 'In epithelial tissues, cells tightly connect to each other through cell–cell
    junctions, but they also present the remarkable capacity of reorganizing themselves
    without compromising tissue integrity. Upon injury, simple epithelia efficiently
    resolve small lesions through the action of actin cytoskeleton contractile structures
    at the wound edge and cellular rearrangements. However, the underlying mechanisms
    and how they cooperate are still poorly understood. In this study, we combine
    live imaging and theoretical modeling to reveal a novel and indispensable role
    for occluding junctions (OJs) in this process. We demonstrate that OJ loss of
    function leads to defects in wound-closure dynamics: instead of contracting, wounds
    dramatically increase their area. OJ mutants exhibit phenotypes in cell shape,
    cellular rearrangements, and mechanical properties as well as in actin cytoskeleton
    dynamics at the wound edge. We propose that OJs are essential for wound closure
    by impacting on epithelial mechanics at the tissue level, which in turn is crucial
    for correct regulation of the cellular events occurring at the wound edge.'
article_processing_charge: No
author:
- first_name: Lara
  full_name: Carvalho, Lara
  last_name: Carvalho
- first_name: Pedro
  full_name: Patricio, Pedro
  last_name: Patricio
- first_name: Susana
  full_name: Ponte, Susana
  last_name: Ponte
- first_name: Carl-Philipp J
  full_name: Heisenberg, Carl-Philipp J
  id: 39427864-F248-11E8-B48F-1D18A9856A87
  last_name: Heisenberg
  orcid: 0000-0002-0912-4566
- first_name: Luis
  full_name: Almeida, Luis
  last_name: Almeida
- first_name: André S.
  full_name: Nunes, André S.
  last_name: Nunes
- first_name: Nuno A.M.
  full_name: Araújo, Nuno A.M.
  last_name: Araújo
- first_name: Antonio
  full_name: Jacinto, Antonio
  last_name: Jacinto
citation:
  ama: Carvalho L, Patricio P, Ponte S, et al. Occluding junctions as novel regulators
    of tissue mechanics during wound repair. <i>Journal of Cell Biology</i>. 2018;217(12):4267-4283.
    doi:<a href="https://doi.org/10.1083/jcb.201804048">10.1083/jcb.201804048</a>
  apa: Carvalho, L., Patricio, P., Ponte, S., Heisenberg, C.-P. J., Almeida, L., Nunes,
    A. S., … Jacinto, A. (2018). Occluding junctions as novel regulators of tissue
    mechanics during wound repair. <i>Journal of Cell Biology</i>. Rockefeller University
    Press. <a href="https://doi.org/10.1083/jcb.201804048">https://doi.org/10.1083/jcb.201804048</a>
  chicago: Carvalho, Lara, Pedro Patricio, Susana Ponte, Carl-Philipp J Heisenberg,
    Luis Almeida, André S. Nunes, Nuno A.M. Araújo, and Antonio Jacinto. “Occluding
    Junctions as Novel Regulators of Tissue Mechanics during Wound Repair.” <i>Journal
    of Cell Biology</i>. Rockefeller University Press, 2018. <a href="https://doi.org/10.1083/jcb.201804048">https://doi.org/10.1083/jcb.201804048</a>.
  ieee: L. Carvalho <i>et al.</i>, “Occluding junctions as novel regulators of tissue
    mechanics during wound repair,” <i>Journal of Cell Biology</i>, vol. 217, no.
    12. Rockefeller University Press, pp. 4267–4283, 2018.
  ista: Carvalho L, Patricio P, Ponte S, Heisenberg C-PJ, Almeida L, Nunes AS, Araújo
    NAM, Jacinto A. 2018. Occluding junctions as novel regulators of tissue mechanics
    during wound repair. Journal of Cell Biology. 217(12), 4267–4283.
  mla: Carvalho, Lara, et al. “Occluding Junctions as Novel Regulators of Tissue Mechanics
    during Wound Repair.” <i>Journal of Cell Biology</i>, vol. 217, no. 12, Rockefeller
    University Press, 2018, pp. 4267–83, doi:<a href="https://doi.org/10.1083/jcb.201804048">10.1083/jcb.201804048</a>.
  short: L. Carvalho, P. Patricio, S. Ponte, C.-P.J. Heisenberg, L. Almeida, A.S.
    Nunes, N.A.M. Araújo, A. Jacinto, Journal of Cell Biology 217 (2018) 4267–4283.
date_created: 2018-12-16T22:59:19Z
date_published: 2018-12-01T00:00:00Z
date_updated: 2023-09-13T09:11:17Z
day: '01'
department:
- _id: CaHe
doi: 10.1083/jcb.201804048
ec_funded: 1
external_id:
  isi:
  - '000451960800018'
  pmid:
  - '30228162 '
intvolume: '       217'
isi: 1
issue: '12'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://www.ncbi.nlm.nih.gov/pubmed/30228162
month: '12'
oa: 1
oa_version: Submitted Version
page: 4267-4283
pmid: 1
project:
- _id: 25681D80-B435-11E9-9278-68D0E5697425
  call_identifier: FP7
  grant_number: '291734'
  name: International IST Postdoc Fellowship Programme
publication: Journal of Cell Biology
publication_identifier:
  issn:
  - '00219525'
publication_status: published
publisher: Rockefeller University Press
quality_controlled: '1'
scopus_import: '1'
status: public
title: Occluding junctions as novel regulators of tissue mechanics during wound repair
type: journal_article
user_id: c635000d-4b10-11ee-a964-aac5a93f6ac1
volume: 217
year: '2018'
...
---
_id: '5677'
abstract:
- lang: eng
  text: 'Recently, contract-based design has been proposed as an “orthogonal” approach
    that complements system design methodologies proposed so far to cope with the
    complexity of system design. Contract-based design provides a rigorous scaffolding
    for verification, analysis, abstraction/refinement, and even synthesis. A number
    of results have been obtained in this domain but a unified treatment of the topic
    that can help put contract-based design in perspective was missing. This monograph
    intends to provide such a treatment where contracts are precisely defined and
    characterized so that they can be used in design methodologies with no ambiguity.
    In particular, this monograph identifies the essence of complex system design
    using contracts through a mathematical “meta-theory”, where all the properties
    of the methodology are derived from a very abstract and generic notion of contract.
    We show that the meta-theory provides deep and illuminating links with existing
    contract and interface theories, as well as guidelines for designing new theories.
    Our study encompasses contracts for both software and systems, with emphasis on
    the latter. We illustrate the use of contracts with two examples: requirement
    engineering for a parking garage management, and the development of contracts
    for timing and scheduling in the context of the Autosar methodology in use in
    the automotive sector.'
article_processing_charge: No
article_type: original
author:
- first_name: Albert
  full_name: Benveniste, Albert
  last_name: Benveniste
- first_name: Dejan
  full_name: Nickovic, Dejan
  last_name: Nickovic
- first_name: Benoît
  full_name: Caillaud, Benoît
  last_name: Caillaud
- first_name: Roberto
  full_name: Passerone, Roberto
  last_name: Passerone
- first_name: Jean Baptiste
  full_name: Raclet, Jean Baptiste
  last_name: Raclet
- first_name: Philipp
  full_name: Reinkemeier, Philipp
  last_name: Reinkemeier
- first_name: Alberto
  full_name: Sangiovanni-Vincentelli, Alberto
  last_name: Sangiovanni-Vincentelli
- first_name: Werner
  full_name: Damm, Werner
  last_name: Damm
- first_name: Thomas A
  full_name: Henzinger, Thomas A
  id: 40876CD8-F248-11E8-B48F-1D18A9856A87
  last_name: Henzinger
  orcid: 0000−0002−2985−7724
- first_name: Kim G.
  full_name: Larsen, Kim G.
  last_name: Larsen
citation:
  ama: Benveniste A, Nickovic D, Caillaud B, et al. Contracts for system design. <i>Foundations
    and Trends in Electronic Design Automation</i>. 2018;12(2-3):124-400. doi:<a href="https://doi.org/10.1561/1000000053">10.1561/1000000053</a>
  apa: Benveniste, A., Nickovic, D., Caillaud, B., Passerone, R., Raclet, J. B., Reinkemeier,
    P., … Larsen, K. G. (2018). Contracts for system design. <i>Foundations and Trends
    in Electronic Design Automation</i>. Now Publishers. <a href="https://doi.org/10.1561/1000000053">https://doi.org/10.1561/1000000053</a>
  chicago: Benveniste, Albert, Dejan Nickovic, Benoît Caillaud, Roberto Passerone,
    Jean Baptiste Raclet, Philipp Reinkemeier, Alberto Sangiovanni-Vincentelli, Werner
    Damm, Thomas A Henzinger, and Kim G. Larsen. “Contracts for System Design.” <i>Foundations
    and Trends in Electronic Design Automation</i>. Now Publishers, 2018. <a href="https://doi.org/10.1561/1000000053">https://doi.org/10.1561/1000000053</a>.
  ieee: A. Benveniste <i>et al.</i>, “Contracts for system design,” <i>Foundations
    and Trends in Electronic Design Automation</i>, vol. 12, no. 2–3. Now Publishers,
    pp. 124–400, 2018.
  ista: Benveniste A, Nickovic D, Caillaud B, Passerone R, Raclet JB, Reinkemeier
    P, Sangiovanni-Vincentelli A, Damm W, Henzinger TA, Larsen KG. 2018. Contracts
    for system design. Foundations and Trends in Electronic Design Automation. 12(2–3),
    124–400.
  mla: Benveniste, Albert, et al. “Contracts for System Design.” <i>Foundations and
    Trends in Electronic Design Automation</i>, vol. 12, no. 2–3, Now Publishers,
    2018, pp. 124–400, doi:<a href="https://doi.org/10.1561/1000000053">10.1561/1000000053</a>.
  short: A. Benveniste, D. Nickovic, B. Caillaud, R. Passerone, J.B. Raclet, P. Reinkemeier,
    A. Sangiovanni-Vincentelli, W. Damm, T.A. Henzinger, K.G. Larsen, Foundations
    and Trends in Electronic Design Automation 12 (2018) 124–400.
date_created: 2018-12-16T22:59:19Z
date_published: 2018-05-01T00:00:00Z
date_updated: 2023-10-17T11:53:09Z
day: '01'
department:
- _id: ToHe
doi: 10.1561/1000000053
intvolume: '        12'
issue: 2-3
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://hal.inria.fr/hal-00757488/
month: '05'
oa: 1
oa_version: Submitted Version
page: 124-400
publication: Foundations and Trends in Electronic Design Automation
publication_identifier:
  issn:
  - 1551-3939
publication_status: published
publisher: Now Publishers
quality_controlled: '1'
scopus_import: '1'
status: public
title: Contracts for system design
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 12
year: '2018'
...
---
_id: '5679'
abstract:
- lang: eng
  text: We study the almost-sure termination problem for probabilistic programs. First,
    we show that supermartingales with lower bounds on conditional absolute difference
    provide a sound approach for the almost-sure termination problem. Moreover, using
    this approach we can obtain explicit optimal bounds on tail probabilities of non-termination
    within a given number of steps. Second, we present a new approach based on Central
    Limit Theorem for the almost-sure termination problem, and show that this approach
    can establish almost-sure termination of programs which none of the existing approaches
    can handle. Finally, we discuss algorithmic approaches for the two above methods
    that lead to automated analysis techniques for almost-sure termination of probabilistic
    programs.
alternative_title:
- LNCS
article_processing_charge: No
arxiv: 1
author:
- first_name: Mingzhang
  full_name: Huang, Mingzhang
  last_name: Huang
- first_name: Hongfei
  full_name: Fu, Hongfei
  last_name: Fu
- first_name: Krishnendu
  full_name: Chatterjee, Krishnendu
  id: 2E5DCA20-F248-11E8-B48F-1D18A9856A87
  last_name: Chatterjee
  orcid: 0000-0002-4561-241X
citation:
  ama: 'Huang M, Fu H, Chatterjee K. New approaches for almost-sure termination of
    probabilistic programs. In: Ryu S, ed. Vol 11275. Springer; 2018:181-201. doi:<a
    href="https://doi.org/10.1007/978-3-030-02768-1_11">10.1007/978-3-030-02768-1_11</a>'
  apa: 'Huang, M., Fu, H., &#38; Chatterjee, K. (2018). New approaches for almost-sure
    termination of probabilistic programs. In S. Ryu (Ed.) (Vol. 11275, pp. 181–201).
    Presented at the 16th Asian Symposium on Programming Languages and Systems, APLAS,
    Wellington, New Zealand: Springer. <a href="https://doi.org/10.1007/978-3-030-02768-1_11">https://doi.org/10.1007/978-3-030-02768-1_11</a>'
  chicago: Huang, Mingzhang, Hongfei Fu, and Krishnendu Chatterjee. “New Approaches
    for Almost-Sure Termination of Probabilistic Programs.” edited by Sukyoung Ryu,
    11275:181–201. Springer, 2018. <a href="https://doi.org/10.1007/978-3-030-02768-1_11">https://doi.org/10.1007/978-3-030-02768-1_11</a>.
  ieee: M. Huang, H. Fu, and K. Chatterjee, “New approaches for almost-sure termination
    of probabilistic programs,” presented at the 16th Asian Symposium on Programming
    Languages and Systems, APLAS, Wellington, New Zealand, 2018, vol. 11275, pp. 181–201.
  ista: Huang M, Fu H, Chatterjee K. 2018. New approaches for almost-sure termination
    of probabilistic programs. 16th Asian Symposium on Programming Languages and Systems,
    APLAS, LNCS, vol. 11275, 181–201.
  mla: Huang, Mingzhang, et al. <i>New Approaches for Almost-Sure Termination of Probabilistic
    Programs</i>. Edited by Sukyoung Ryu, vol. 11275, Springer, 2018, pp. 181–201,
    doi:<a href="https://doi.org/10.1007/978-3-030-02768-1_11">10.1007/978-3-030-02768-1_11</a>.
  short: M. Huang, H. Fu, K. Chatterjee, in:, S. Ryu (Ed.), Springer, 2018, pp. 181–201.
conference:
  end_date: 2018-12-06
  location: Wellington, New Zealand
  name: 16th Asian Symposium on Programming Languages and Systems, APLAS
  start_date: 2018-12-02
date_created: 2018-12-16T22:59:20Z
date_published: 2018-12-01T00:00:00Z
date_updated: 2025-06-02T08:53:41Z
day: '01'
department:
- _id: KrCh
doi: 10.1007/978-3-030-02768-1_11
editor:
- first_name: Sukyoung
  full_name: Ryu, Sukyoung
  last_name: Ryu
external_id:
  arxiv:
  - '1806.06683'
  isi:
  - '000916310900011'
intvolume: '     11275'
isi: 1
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: http://arxiv.org/abs/1806.06683
month: '12'
oa: 1
oa_version: Preprint
page: 181-201
project:
- _id: 25832EC2-B435-11E9-9278-68D0E5697425
  call_identifier: FWF
  grant_number: S 11407_N23
  name: Rigorous Systems Engineering
- _id: 25892FC0-B435-11E9-9278-68D0E5697425
  grant_number: ICT15-003
  name: Efficient Algorithms for Computer Aided Verification
publication_identifier:
  isbn:
  - '9783030027674'
  issn:
  - '03029743'
publisher: Springer
quality_controlled: '1'
scopus_import: '1'
status: public
title: New approaches for almost-sure termination of probabilistic programs
type: conference
user_id: c635000d-4b10-11ee-a964-aac5a93f6ac1
volume: 11275
year: '2018'
...
---
_id: '5686'
article_processing_charge: No
author:
- first_name: Patrick
  full_name: Danowski, Patrick
  id: 2EBD1598-F248-11E8-B48F-1D18A9856A87
  last_name: Danowski
  orcid: 0000-0002-6026-4409
citation:
  ama: Danowski P. <i>An Austrian Proposal for the Classification of Open Access Tuples
    (COAT) - Distinguish Different Open Access Types beyond Colors</i>.; 2018. doi:<a
    href="https://doi.org/10.5281/zenodo.1244154">10.5281/zenodo.1244154</a>
  apa: Danowski, P. (2018). <i>An Austrian proposal for the Classification of Open
    Access Tuples (COAT) - Distinguish different Open Access types beyond colors</i>.
    <a href="https://doi.org/10.5281/zenodo.1244154">https://doi.org/10.5281/zenodo.1244154</a>
  chicago: Danowski, Patrick. <i>An Austrian Proposal for the Classification of Open
    Access Tuples (COAT) - Distinguish Different Open Access Types beyond Colors</i>,
    2018. <a href="https://doi.org/10.5281/zenodo.1244154">https://doi.org/10.5281/zenodo.1244154</a>.
  ieee: P. Danowski, <i>An Austrian proposal for the Classification of Open Access
    Tuples (COAT) - Distinguish different Open Access types beyond colors</i>. 2018.
  ista: Danowski P. 2018. An Austrian proposal for the Classification of Open Access
    Tuples (COAT) - Distinguish different Open Access types beyond colors, 5p.
  mla: Danowski, Patrick. <i>An Austrian Proposal for the Classification of Open Access
    Tuples (COAT) - Distinguish Different Open Access Types beyond Colors</i>. 2018,
    doi:<a href="https://doi.org/10.5281/zenodo.1244154">10.5281/zenodo.1244154</a>.
  short: P. Danowski, An Austrian Proposal for the Classification of Open Access Tuples
    (COAT) - Distinguish Different Open Access Types beyond Colors, 2018.
date_created: 2018-12-17T10:28:26Z
date_published: 2018-05-09T00:00:00Z
date_updated: 2023-10-17T11:33:57Z
day: '09'
ddc:
- '020'
department:
- _id: E-Lib
doi: 10.5281/zenodo.1244154
file:
- access_level: open_access
  checksum: 6cb95f8772491d155ce77c6160655fff
  content_type: application/pdf
  creator: dernst
  date_created: 2019-01-22T09:06:51Z
  date_updated: 2020-07-14T12:47:10Z
  file_id: '5872'
  file_name: 2018_WorkingPaper_Danowski.pdf
  file_size: 202798
  relation: main_file
file_date_updated: 2020-07-14T12:47:10Z
has_accepted_license: '1'
language:
- iso: eng
month: '05'
oa: 1
oa_version: Published Version
page: '5'
publication_status: published
related_material:
  record:
  - id: '6657'
    relation: later_version
    status: public
scopus_import: 1
status: public
title: An Austrian proposal for the Classification of Open Access Tuples (COAT) -
  Distinguish different Open Access types beyond colors
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: working_paper
user_id: 3E5EF7F0-F248-11E8-B48F-1D18A9856A87
year: '2018'
...
---
_id: '5751'
abstract:
- lang: eng
  text: 'Because of the intrinsic randomness of the evolutionary process, a mutant
    with a fitness advantage has some chance to be selected but no certainty. Any
    experiment that searches for advantageous mutants will lose many of them due to
    random drift. It is therefore of great interest to find population structures
    that improve the odds of advantageous mutants. Such structures are called amplifiers
    of natural selection: they increase the probability that advantageous mutants
    are selected. Arbitrarily strong amplifiers guarantee the selection of advantageous
    mutants, even for very small fitness advantage. Despite intensive research over
    the past decade, arbitrarily strong amplifiers have remained rare. Here we show
    how to construct a large variety of them. Our amplifiers are so simple that they
    could be useful in biotechnology, when optimizing biological molecules, or as
    a diagnostic tool, when searching for faster dividing cells or viruses. They could
    also occur in natural population structures.'
article_number: '71'
article_processing_charge: No
author:
- first_name: Andreas
  full_name: Pavlogiannis, Andreas
  id: 49704004-F248-11E8-B48F-1D18A9856A87
  last_name: Pavlogiannis
  orcid: 0000-0002-8943-0722
- first_name: Josef
  full_name: Tkadlec, Josef
  id: 3F24CCC8-F248-11E8-B48F-1D18A9856A87
  last_name: Tkadlec
  orcid: 0000-0002-1097-9684
- first_name: Krishnendu
  full_name: Chatterjee, Krishnendu
  id: 2E5DCA20-F248-11E8-B48F-1D18A9856A87
  last_name: Chatterjee
  orcid: 0000-0002-4561-241X
- first_name: Martin A.
  full_name: Nowak, Martin A.
  last_name: Nowak
citation:
  ama: Pavlogiannis A, Tkadlec J, Chatterjee K, Nowak MA. Construction of arbitrarily
    strong amplifiers of natural selection using evolutionary graph theory. <i>Communications
    Biology</i>. 2018;1(1). doi:<a href="https://doi.org/10.1038/s42003-018-0078-7">10.1038/s42003-018-0078-7</a>
  apa: Pavlogiannis, A., Tkadlec, J., Chatterjee, K., &#38; Nowak, M. A. (2018). Construction
    of arbitrarily strong amplifiers of natural selection using evolutionary graph
    theory. <i>Communications Biology</i>. Springer Nature. <a href="https://doi.org/10.1038/s42003-018-0078-7">https://doi.org/10.1038/s42003-018-0078-7</a>
  chicago: Pavlogiannis, Andreas, Josef Tkadlec, Krishnendu Chatterjee, and Martin
    A. Nowak. “Construction of Arbitrarily Strong Amplifiers of Natural Selection
    Using Evolutionary Graph Theory.” <i>Communications Biology</i>. Springer Nature,
    2018. <a href="https://doi.org/10.1038/s42003-018-0078-7">https://doi.org/10.1038/s42003-018-0078-7</a>.
  ieee: A. Pavlogiannis, J. Tkadlec, K. Chatterjee, and M. A. Nowak, “Construction
    of arbitrarily strong amplifiers of natural selection using evolutionary graph
    theory,” <i>Communications Biology</i>, vol. 1, no. 1. Springer Nature, 2018.
  ista: Pavlogiannis A, Tkadlec J, Chatterjee K, Nowak MA. 2018. Construction of arbitrarily
    strong amplifiers of natural selection using evolutionary graph theory. Communications
    Biology. 1(1), 71.
  mla: Pavlogiannis, Andreas, et al. “Construction of Arbitrarily Strong Amplifiers
    of Natural Selection Using Evolutionary Graph Theory.” <i>Communications Biology</i>,
    vol. 1, no. 1, 71, Springer Nature, 2018, doi:<a href="https://doi.org/10.1038/s42003-018-0078-7">10.1038/s42003-018-0078-7</a>.
  short: A. Pavlogiannis, J. Tkadlec, K. Chatterjee, M.A. Nowak, Communications Biology
    1 (2018).
date_created: 2018-12-18T13:22:58Z
date_published: 2018-06-14T00:00:00Z
date_updated: 2024-02-21T13:48:42Z
day: '14'
ddc:
- '004'
- '519'
- '576'
department:
- _id: KrCh
doi: 10.1038/s42003-018-0078-7
ec_funded: 1
external_id:
  isi:
  - '000461126500071'
file:
- access_level: open_access
  checksum: a9db825fa3b64a51ff3de035ec973b3e
  content_type: application/pdf
  creator: dernst
  date_created: 2018-12-18T13:37:04Z
  date_updated: 2020-07-14T12:47:10Z
  file_id: '5752'
  file_name: 2018_CommBiology_Pavlogiannis.pdf
  file_size: 1804194
  relation: main_file
file_date_updated: 2020-07-14T12:47:10Z
has_accepted_license: '1'
intvolume: '         1'
isi: 1
issue: '1'
language:
- iso: eng
month: '06'
oa: 1
oa_version: Published Version
project:
- _id: 2581B60A-B435-11E9-9278-68D0E5697425
  call_identifier: FP7
  grant_number: '279307'
  name: 'Quantitative Graph Games: Theory and Applications'
- _id: 2584A770-B435-11E9-9278-68D0E5697425
  call_identifier: FWF
  grant_number: P 23499-N23
  name: Modern Graph Algorithmic Techniques in Formal Verification
- _id: 25832EC2-B435-11E9-9278-68D0E5697425
  call_identifier: FWF
  grant_number: S 11407_N23
  name: Rigorous Systems Engineering
publication: Communications Biology
publication_identifier:
  issn:
  - 2399-3642
publication_status: published
publisher: Springer Nature
pubrep_id: '1045'
quality_controlled: '1'
related_material:
  record:
  - id: '7196'
    relation: part_of_dissertation
    status: public
  - id: '5559'
    relation: popular_science
    status: public
scopus_import: '1'
status: public
title: Construction of arbitrarily strong amplifiers of natural selection using evolutionary
  graph theory
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: c635000d-4b10-11ee-a964-aac5a93f6ac1
volume: 1
year: '2018'
...
---
_id: '5757'
abstract:
- lang: eng
  text: "File S1. Variant Calling Format file of the ingroup: 197 haploid sequences
    of D. melanogaster from Zambia (Africa) aligned to the D. melanogaster 5.57 reference
    genome.\r\n\r\nFile S2. Variant Calling Format file of the outgroup: 1 haploid
    sequence of D. simulans aligned to the D. melanogaster 5.57 reference genome.\r\n\r\nFile
    S3. Annotations of each transcript in coding regions with SNPeff: Ps (# of synonymous
    polymorphic sites); Pn (# of non-synonymous polymorphic sites); Ds (# of synonymous
    divergent sites); Dn (# of non-synonymous divergent sites); DoS; ⍺ MK . All variants
    were included.\r\n\r\nFile S4. Annotations of each transcript in non-coding regions
    with SNPeff: Ps (# of synonymous polymorphic sites); Pu (# of UTR polymorphic
    sites); Ds (# of synonymous divergent sites); Du (# of UTR divergent sites); DoS;
    ⍺ MK . All variants were included.\r\n\r\nFile S5. Annotations of each transcript
    in coding regions with SNPGenie: Ps (# of synonymous polymorphic sites); πs (synonymous
    diversity); Ss_p (total # of synonymous sites in the polymorphism data); Pn (#
    of non-synonymous polymorphic sites); πn (non-synonymous diversity); Sn_p (total
    # of non-synonymous sites in the polymorphism data); Ds (# of synonymous divergent
    sites); ks (synonymous evolutionary rate); Ss_d (total # of synonymous sites in
    the divergence data); Dn (# of non-synonymous divergent sites); kn (non-synonymous
    evolutionary rate); Sn_d (total # of non-\r\nsynonymous sites in the divergence
    data); DoS; ⍺ MK . All variants were included.\r\n\r\nFile S6. Gene expression
    values (RPKM summed over all transcripts) for each sample. Values were quantile-normalized
    across all samples.\r\n\r\nFile S7. Final dataset with all covariates, ⍺ MK ,
    ωA MK and DoS for coding sites, excluding variants below 5% frequency.\r\n\r\nFile
    S8. Final dataset with all covariates, ⍺ MK , ωA MK and DoS for non-coding sites,
    excluding variants below 5%\r\nfrequency.\r\n\r\nFile S9. Final dataset with all
    covariates, ⍺ EWK , ωA EWK and deleterious SFS for coding sites obtained with
    the Eyre-Walker and Keightley method on binned data and using all variants."
article_processing_charge: No
author:
- first_name: Christelle
  full_name: Fraisse, Christelle
  id: 32DF5794-F248-11E8-B48F-1D18A9856A87
  last_name: Fraisse
  orcid: 0000-0001-8441-5075
citation:
  ama: Fraisse C. Supplementary Files for “Pleiotropy modulates the efficacy of selection
    in Drosophila melanogaster.” 2018. doi:<a href="https://doi.org/10.15479/at:ista:/5757">10.15479/at:ista:/5757</a>
  apa: Fraisse, C. (2018). Supplementary Files for “Pleiotropy modulates the efficacy
    of selection in Drosophila melanogaster.” Institute of Science and Technology
    Austria. <a href="https://doi.org/10.15479/at:ista:/5757">https://doi.org/10.15479/at:ista:/5757</a>
  chicago: Fraisse, Christelle. “Supplementary Files for ‘Pleiotropy Modulates the
    Efficacy of Selection in Drosophila Melanogaster.’” Institute of Science and Technology
    Austria, 2018. <a href="https://doi.org/10.15479/at:ista:/5757">https://doi.org/10.15479/at:ista:/5757</a>.
  ieee: C. Fraisse, “Supplementary Files for ‘Pleiotropy modulates the efficacy of
    selection in Drosophila melanogaster.’” Institute of Science and Technology Austria,
    2018.
  ista: Fraisse C. 2018. Supplementary Files for ‘Pleiotropy modulates the efficacy
    of selection in Drosophila melanogaster’, Institute of Science and Technology
    Austria, <a href="https://doi.org/10.15479/at:ista:/5757">10.15479/at:ista:/5757</a>.
  mla: Fraisse, Christelle. <i>Supplementary Files for “Pleiotropy Modulates the Efficacy
    of Selection in Drosophila Melanogaster.”</i> Institute of Science and Technology
    Austria, 2018, doi:<a href="https://doi.org/10.15479/at:ista:/5757">10.15479/at:ista:/5757</a>.
  short: C. Fraisse, (2018).
contributor:
- first_name: Christelle
  id: 32DF5794-F248-11E8-B48F-1D18A9856A87
  last_name: Fraisse
- first_name: Gemma
  id: 33AB266C-F248-11E8-B48F-1D18A9856A87
  last_name: Puixeu Sala
- first_name: Beatriz
  id: 49E1C5C6-F248-11E8-B48F-1D18A9856A87
  last_name: Vicoso
  orcid: 0000-0002-4579-8306
date_created: 2018-12-19T14:22:35Z
date_published: 2018-12-19T00:00:00Z
date_updated: 2024-02-21T13:59:18Z
day: '19'
ddc:
- '576'
department:
- _id: BeVi
- _id: NiBa
doi: 10.15479/at:ista:/5757
ec_funded: 1
file:
- access_level: open_access
  checksum: aed7ee9ca3f4dc07d8a66945f68e13cd
  content_type: application/zip
  creator: cfraisse
  date_created: 2018-12-19T14:19:52Z
  date_updated: 2020-07-14T12:47:11Z
  file_id: '5758'
  file_name: FileS1.zip
  file_size: 369837892
  relation: main_file
- access_level: open_access
  checksum: 3592e467b4d8206650860b612d6e12f3
  content_type: application/zip
  creator: cfraisse
  date_created: 2018-12-19T14:19:49Z
  date_updated: 2020-07-14T12:47:11Z
  file_id: '5759'
  file_name: FileS2.zip
  file_size: 84856909
  relation: main_file
- access_level: open_access
  checksum: c37ac5d5437c457338afc128c1240655
  content_type: text/plain
  creator: cfraisse
  date_created: 2018-12-19T14:19:49Z
  date_updated: 2020-07-14T12:47:11Z
  file_id: '5760'
  file_name: FileS3.txt
  file_size: 881133
  relation: main_file
- access_level: open_access
  checksum: 943dfd14da61817441e33e3e3cb8cdb9
  content_type: text/plain
  creator: cfraisse
  date_created: 2018-12-19T14:19:49Z
  date_updated: 2020-07-14T12:47:11Z
  file_id: '5761'
  file_name: FileS4.txt
  file_size: 883742
  relation: main_file
- access_level: open_access
  checksum: 1c669b6c4690ec1bbca3e2da9f566d17
  content_type: text/plain
  creator: cfraisse
  date_created: 2018-12-19T14:19:49Z
  date_updated: 2020-07-14T12:47:11Z
  file_id: '5762'
  file_name: FileS5.txt
  file_size: 2495437
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  checksum: f40f661b987ca6fb6b47f650cbbb04e6
  content_type: text/plain
  creator: cfraisse
  date_created: 2018-12-19T14:19:50Z
  date_updated: 2020-07-14T12:47:11Z
  file_id: '5763'
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  creator: cfraisse
  date_created: 2018-12-19T14:19:50Z
  date_updated: 2020-07-14T12:47:11Z
  file_id: '5764'
  file_name: FileS7.txt
  file_size: 2584120
  relation: main_file
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  checksum: f6c0bd3e63e14ddf5445bd69b43a9152
  content_type: text/plain
  creator: cfraisse
  date_created: 2018-12-19T14:19:50Z
  date_updated: 2020-07-14T12:47:11Z
  file_id: '5765'
  file_name: FileS8.txt
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  checksum: 0fe7a58a030b11bf3b9c8ff7a7addcae
  content_type: text/plain
  creator: cfraisse
  date_created: 2018-12-19T14:19:50Z
  date_updated: 2020-07-14T12:47:11Z
  file_id: '5766'
  file_name: FileS9.txt
  file_size: 100737
  relation: main_file
file_date_updated: 2020-07-14T12:47:11Z
has_accepted_license: '1'
keyword:
- (mal)adaptation
- pleiotropy
- selective constraint
- evo-devo
- gene expression
- Drosophila melanogaster
month: '12'
oa: 1
oa_version: Published Version
project:
- _id: 25681D80-B435-11E9-9278-68D0E5697425
  call_identifier: FP7
  grant_number: '291734'
  name: International IST Postdoc Fellowship Programme
publisher: Institute of Science and Technology Austria
related_material:
  record:
  - id: '6089'
    relation: research_paper
    status: public
status: public
title: Supplementary Files for "Pleiotropy modulates the efficacy of selection in
  Drosophila melanogaster"
type: research_data
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '2018'
...
---
_id: '5767'
abstract:
- lang: eng
  text: 'Cuprate superconductors have long been thought of as having strong electronic
    correlations but negligible spin-orbit coupling. Using spin- and angle-resolved
    photoemission spectroscopy, we discovered that one of the most studied cuprate
    superconductors, Bi2212, has a nontrivial spin texture with a spin-momentum locking
    that circles the Brillouin zone center and a spin-layer locking that allows states
    of opposite spin to be localized in different parts of the unit cell. Our findings
    pose challenges for the vast majority of models of cuprates, such as the Hubbard
    model and its variants, where spin-orbit interaction has been mostly neglected,
    and open the intriguing question of how the high-temperature superconducting state
    emerges in the presence of this nontrivial spin texture. '
acknowledgement: ' M.S. was supported by the Gordon and Betty Moore Foundation s EPiQS
  Initiative through grant GBMF4307'
article_processing_charge: No
article_type: original
author:
- first_name: Kenneth
  full_name: Gotlieb, Kenneth
  last_name: Gotlieb
- first_name: Chiu-Yun
  full_name: Lin, Chiu-Yun
  last_name: Lin
- first_name: Maksym
  full_name: Serbyn, Maksym
  id: 47809E7E-F248-11E8-B48F-1D18A9856A87
  last_name: Serbyn
  orcid: 0000-0002-2399-5827
- first_name: Wentao
  full_name: Zhang, Wentao
  last_name: Zhang
- first_name: Christopher L.
  full_name: Smallwood, Christopher L.
  last_name: Smallwood
- first_name: Christopher
  full_name: Jozwiak, Christopher
  last_name: Jozwiak
- first_name: Hiroshi
  full_name: Eisaki, Hiroshi
  last_name: Eisaki
- first_name: Zahid
  full_name: Hussain, Zahid
  last_name: Hussain
- first_name: Ashvin
  full_name: Vishwanath, Ashvin
  last_name: Vishwanath
- first_name: Alessandra
  full_name: Lanzara, Alessandra
  last_name: Lanzara
citation:
  ama: Gotlieb K, Lin C-Y, Serbyn M, et al. Revealing hidden spin-momentum locking
    in a high-temperature cuprate superconductor. <i>Science</i>. 2018;362(6420):1271-1275.
    doi:<a href="https://doi.org/10.1126/science.aao0980">10.1126/science.aao0980</a>
  apa: Gotlieb, K., Lin, C.-Y., Serbyn, M., Zhang, W., Smallwood, C. L., Jozwiak,
    C., … Lanzara, A. (2018). Revealing hidden spin-momentum locking in a high-temperature
    cuprate superconductor. <i>Science</i>. American Association for the Advancement
    of Science. <a href="https://doi.org/10.1126/science.aao0980">https://doi.org/10.1126/science.aao0980</a>
  chicago: Gotlieb, Kenneth, Chiu-Yun Lin, Maksym Serbyn, Wentao Zhang, Christopher
    L. Smallwood, Christopher Jozwiak, Hiroshi Eisaki, Zahid Hussain, Ashvin Vishwanath,
    and Alessandra Lanzara. “Revealing Hidden Spin-Momentum Locking in a High-Temperature
    Cuprate Superconductor.” <i>Science</i>. American Association for the Advancement
    of Science, 2018. <a href="https://doi.org/10.1126/science.aao0980">https://doi.org/10.1126/science.aao0980</a>.
  ieee: K. Gotlieb <i>et al.</i>, “Revealing hidden spin-momentum locking in a high-temperature
    cuprate superconductor,” <i>Science</i>, vol. 362, no. 6420. American Association
    for the Advancement of Science, pp. 1271–1275, 2018.
  ista: Gotlieb K, Lin C-Y, Serbyn M, Zhang W, Smallwood CL, Jozwiak C, Eisaki H,
    Hussain Z, Vishwanath A, Lanzara A. 2018. Revealing hidden spin-momentum locking
    in a high-temperature cuprate superconductor. Science. 362(6420), 1271–1275.
  mla: Gotlieb, Kenneth, et al. “Revealing Hidden Spin-Momentum Locking in a High-Temperature
    Cuprate Superconductor.” <i>Science</i>, vol. 362, no. 6420, American Association
    for the Advancement of Science, 2018, pp. 1271–75, doi:<a href="https://doi.org/10.1126/science.aao0980">10.1126/science.aao0980</a>.
  short: K. Gotlieb, C.-Y. Lin, M. Serbyn, W. Zhang, C.L. Smallwood, C. Jozwiak, H.
    Eisaki, Z. Hussain, A. Vishwanath, A. Lanzara, Science 362 (2018) 1271–1275.
date_created: 2018-12-19T14:53:50Z
date_published: 2018-12-14T00:00:00Z
date_updated: 2023-09-18T08:11:56Z
day: '14'
department:
- _id: MaSe
doi: 10.1126/science.aao0980
external_id:
  isi:
  - '000452994400048'
intvolume: '       362'
isi: 1
issue: '6420'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://doi.org/10.1126/science.aao0980
month: '12'
oa: 1
oa_version: Published Version
page: 1271-1275
publication: Science
publication_identifier:
  eissn:
  - 1095-9203
  issn:
  - 0036-8075
publication_status: published
publisher: American Association for the Advancement of Science
quality_controlled: '1'
scopus_import: '1'
status: public
title: Revealing hidden spin-momentum locking in a high-temperature cuprate superconductor
type: journal_article
user_id: c635000d-4b10-11ee-a964-aac5a93f6ac1
volume: 362
year: '2018'
...
---
_id: '5770'
abstract:
- lang: eng
  text: Retroviruses assemble and bud from infected cells in an immature form and
    require proteolytic maturation for infectivity. The CA (capsid) domains of the
    Gag polyproteins assemble a protein lattice as a truncated sphere in the immature
    virion. Proteolytic cleavage of Gag induces dramatic structural rearrangements;
    a subset of cleaved CA subsequently assembles into the mature core, whose architecture
    varies among retroviruses. Murine leukemia virus (MLV) is the prototypical γ-retrovirus
    and serves as the basis of retroviral vectors, but the structure of the MLV CA
    layer is unknown. Here we have combined X-ray crystallography with cryoelectron
    tomography to determine the structures of immature and mature MLV CA layers within
    authentic viral particles. This reveals the structural changes associated with
    maturation, and, by comparison with HIV-1, uncovers conserved and variable features.
    In contrast to HIV-1, most MLV CA is used for assembly of the mature core, which
    adopts variable, multilayered morphologies and does not form a closed structure.
    Unlike in HIV-1, there is similarity between protein–protein interfaces in the
    immature MLV CA layer and those in the mature CA layer, and structural maturation
    of MLV could be achieved through domain rotations that largely maintain hexameric
    interactions. Nevertheless, the dramatic architectural change on maturation indicates
    that extensive disassembly and reassembly are required for mature core growth.
    The core morphology suggests that wrapping of the genome in CA sheets may be sufficient
    to protect the MLV ribonucleoprotein during cell entry.
article_processing_charge: No
author:
- first_name: Kun
  full_name: Qu, Kun
  last_name: Qu
- first_name: Bärbel
  full_name: Glass, Bärbel
  last_name: Glass
- first_name: Michal
  full_name: Doležal, Michal
  last_name: Doležal
- first_name: Florian
  full_name: Schur, Florian
  id: 48AD8942-F248-11E8-B48F-1D18A9856A87
  last_name: Schur
  orcid: 0000-0003-4790-8078
- first_name: Brice
  full_name: Murciano, Brice
  last_name: Murciano
- first_name: Alan
  full_name: Rein, Alan
  last_name: Rein
- first_name: Michaela
  full_name: Rumlová, Michaela
  last_name: Rumlová
- first_name: Tomáš
  full_name: Ruml, Tomáš
  last_name: Ruml
- first_name: Hans-Georg
  full_name: Kräusslich, Hans-Georg
  last_name: Kräusslich
- first_name: John A. G.
  full_name: Briggs, John A. G.
  last_name: Briggs
citation:
  ama: Qu K, Glass B, Doležal M, et al. Structure and architecture of immature and
    mature murine leukemia virus capsids. <i>Proceedings of the National Academy of
    Sciences</i>. 2018;115(50):E11751-E11760. doi:<a href="https://doi.org/10.1073/pnas.1811580115">10.1073/pnas.1811580115</a>
  apa: Qu, K., Glass, B., Doležal, M., Schur, F. K., Murciano, B., Rein, A., … Briggs,
    J. A. G. (2018). Structure and architecture of immature and mature murine leukemia
    virus capsids. <i>Proceedings of the National Academy of Sciences</i>. Proceedings
    of the National Academy of Sciences. <a href="https://doi.org/10.1073/pnas.1811580115">https://doi.org/10.1073/pnas.1811580115</a>
  chicago: Qu, Kun, Bärbel Glass, Michal Doležal, Florian KM Schur, Brice Murciano,
    Alan Rein, Michaela Rumlová, Tomáš Ruml, Hans-Georg Kräusslich, and John A. G.
    Briggs. “Structure and Architecture of Immature and Mature Murine Leukemia Virus
    Capsids.” <i>Proceedings of the National Academy of Sciences</i>. Proceedings
    of the National Academy of Sciences, 2018. <a href="https://doi.org/10.1073/pnas.1811580115">https://doi.org/10.1073/pnas.1811580115</a>.
  ieee: K. Qu <i>et al.</i>, “Structure and architecture of immature and mature murine
    leukemia virus capsids,” <i>Proceedings of the National Academy of Sciences</i>,
    vol. 115, no. 50. Proceedings of the National Academy of Sciences, pp. E11751–E11760,
    2018.
  ista: Qu K, Glass B, Doležal M, Schur FK, Murciano B, Rein A, Rumlová M, Ruml T,
    Kräusslich H-G, Briggs JAG. 2018. Structure and architecture of immature and mature
    murine leukemia virus capsids. Proceedings of the National Academy of Sciences.
    115(50), E11751–E11760.
  mla: Qu, Kun, et al. “Structure and Architecture of Immature and Mature Murine Leukemia
    Virus Capsids.” <i>Proceedings of the National Academy of Sciences</i>, vol. 115,
    no. 50, Proceedings of the National Academy of Sciences, 2018, pp. E11751–60,
    doi:<a href="https://doi.org/10.1073/pnas.1811580115">10.1073/pnas.1811580115</a>.
  short: K. Qu, B. Glass, M. Doležal, F.K. Schur, B. Murciano, A. Rein, M. Rumlová,
    T. Ruml, H.-G. Kräusslich, J.A.G. Briggs, Proceedings of the National Academy
    of Sciences 115 (2018) E11751–E11760.
date_created: 2018-12-20T21:09:37Z
date_published: 2018-12-11T00:00:00Z
date_updated: 2023-09-19T09:57:45Z
day: '11'
department:
- _id: FlSc
doi: 10.1073/pnas.1811580115
external_id:
  isi:
  - '000452866000022'
  pmid:
  - '30478053'
intvolume: '       115'
isi: 1
issue: '50'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://www.ncbi.nlm.nih.gov/pubmed/30478053
month: '12'
oa: 1
oa_version: Submitted Version
page: E11751-E11760
pmid: 1
publication: Proceedings of the National Academy of Sciences
publication_identifier:
  issn:
  - '00278424'
publication_status: published
publisher: Proceedings of the National Academy of Sciences
quality_controlled: '1'
scopus_import: '1'
status: public
title: Structure and architecture of immature and mature murine leukemia virus capsids
type: journal_article
user_id: c635000d-4b10-11ee-a964-aac5a93f6ac1
volume: 115
year: '2018'
...
---
_id: '5780'
abstract:
- lang: eng
  text: Bioluminescence is found across the entire tree of life, conferring a spectacular
    set of visually oriented functions from attracting mates to scaring off predators.
    Half a dozen different luciferins, molecules that emit light when enzymatically
    oxidized, are known. However, just one biochemical pathway for luciferin biosynthesis
    has been described in full, which is found only in bacteria. Here, we report identification
    of the fungal luciferase and three other key enzymes that together form the biosynthetic
    cycle of the fungal luciferin from caffeic acid, a simple and widespread metabolite.
    Introduction of the identified genes into the genome of the yeast Pichia pastoris
    along with caffeic acid biosynthesis genes resulted in a strain that is autoluminescent
    in standard media. We analyzed evolution of the enzymes of the luciferin biosynthesis
    cycle and found that fungal bioluminescence emerged through a series of events
    that included two independent gene duplications. The retention of the duplicated
    enzymes of the luciferin pathway in nonluminescent fungi shows that the gene duplication
    was followed by functional sequence divergence of enzymes of at least one gene
    in the biosynthetic pathway and suggests that the evolution of fungal bioluminescence
    proceeded through several closely related stepping stone nonluminescent biochemical
    reactions with adaptive roles. The availability of a complete eukaryotic luciferin
    biosynthesis pathway provides several applications in biomedicine and bioengineering.
article_processing_charge: No
author:
- first_name: Alexey A.
  full_name: Kotlobay, Alexey A.
  last_name: Kotlobay
- first_name: Karen
  full_name: Sarkisyan, Karen
  id: 39A7BF80-F248-11E8-B48F-1D18A9856A87
  last_name: Sarkisyan
  orcid: 0000-0002-5375-6341
- first_name: Yuliana A.
  full_name: Mokrushina, Yuliana A.
  last_name: Mokrushina
- first_name: Marina
  full_name: Marcet-Houben, Marina
  last_name: Marcet-Houben
- first_name: Ekaterina O.
  full_name: Serebrovskaya, Ekaterina O.
  last_name: Serebrovskaya
- first_name: Nadezhda M.
  full_name: Markina, Nadezhda M.
  last_name: Markina
- first_name: Louisa
  full_name: Gonzalez Somermeyer, Louisa
  id: 4720D23C-F248-11E8-B48F-1D18A9856A87
  last_name: Gonzalez Somermeyer
  orcid: 0000-0001-9139-5383
- first_name: Andrey Y.
  full_name: Gorokhovatsky, Andrey Y.
  last_name: Gorokhovatsky
- first_name: Andrey
  full_name: Vvedensky, Andrey
  last_name: Vvedensky
- first_name: Konstantin V.
  full_name: Purtov, Konstantin V.
  last_name: Purtov
- first_name: Valentin N.
  full_name: Petushkov, Valentin N.
  last_name: Petushkov
- first_name: Natalja S.
  full_name: Rodionova, Natalja S.
  last_name: Rodionova
- first_name: Tatiana V.
  full_name: Chepurnyh, Tatiana V.
  last_name: Chepurnyh
- first_name: Liliia
  full_name: Fakhranurova, Liliia
  last_name: Fakhranurova
- first_name: Elena B.
  full_name: Guglya, Elena B.
  last_name: Guglya
- first_name: Rustam
  full_name: Ziganshin, Rustam
  last_name: Ziganshin
- first_name: Aleksandra S.
  full_name: Tsarkova, Aleksandra S.
  last_name: Tsarkova
- first_name: Zinaida M.
  full_name: Kaskova, Zinaida M.
  last_name: Kaskova
- first_name: Victoria
  full_name: Shender, Victoria
  last_name: Shender
- first_name: Maxim
  full_name: Abakumov, Maxim
  last_name: Abakumov
- first_name: Tatiana O.
  full_name: Abakumova, Tatiana O.
  last_name: Abakumova
- first_name: Inna S.
  full_name: Povolotskaya, Inna S.
  last_name: Povolotskaya
- first_name: Fedor M.
  full_name: Eroshkin, Fedor M.
  last_name: Eroshkin
- first_name: Andrey G.
  full_name: Zaraisky, Andrey G.
  last_name: Zaraisky
- first_name: Alexander S.
  full_name: Mishin, Alexander S.
  last_name: Mishin
- first_name: Sergey V.
  full_name: Dolgov, Sergey V.
  last_name: Dolgov
- first_name: Tatiana Y.
  full_name: Mitiouchkina, Tatiana Y.
  last_name: Mitiouchkina
- first_name: Eugene P.
  full_name: Kopantzev, Eugene P.
  last_name: Kopantzev
- first_name: Hans E.
  full_name: Waldenmaier, Hans E.
  last_name: Waldenmaier
- first_name: Anderson G.
  full_name: Oliveira, Anderson G.
  last_name: Oliveira
- first_name: Yuichi
  full_name: Oba, Yuichi
  last_name: Oba
- first_name: Ekaterina
  full_name: Barsova, Ekaterina
  last_name: Barsova
- first_name: Ekaterina A.
  full_name: Bogdanova, Ekaterina A.
  last_name: Bogdanova
- first_name: Toni
  full_name: Gabaldón, Toni
  last_name: Gabaldón
- first_name: Cassius V.
  full_name: Stevani, Cassius V.
  last_name: Stevani
- first_name: Sergey
  full_name: Lukyanov, Sergey
  last_name: Lukyanov
- first_name: Ivan V.
  full_name: Smirnov, Ivan V.
  last_name: Smirnov
- first_name: Josef I.
  full_name: Gitelson, Josef I.
  last_name: Gitelson
- first_name: Fyodor
  full_name: Kondrashov, Fyodor
  id: 44FDEF62-F248-11E8-B48F-1D18A9856A87
  last_name: Kondrashov
  orcid: 0000-0001-8243-4694
- first_name: Ilia V.
  full_name: Yampolsky, Ilia V.
  last_name: Yampolsky
citation:
  ama: Kotlobay AA, Sarkisyan K, Mokrushina YA, et al. Genetically encodable bioluminescent
    system from fungi. <i>Proceedings of the National Academy of Sciences of the United
    States of America</i>. 2018;115(50):12728-12732. doi:<a href="https://doi.org/10.1073/pnas.1803615115">10.1073/pnas.1803615115</a>
  apa: Kotlobay, A. A., Sarkisyan, K., Mokrushina, Y. A., Marcet-Houben, M., Serebrovskaya,
    E. O., Markina, N. M., … Yampolsky, I. V. (2018). Genetically encodable bioluminescent
    system from fungi. <i>Proceedings of the National Academy of Sciences of the United
    States of America</i>. National Academy of Sciences. <a href="https://doi.org/10.1073/pnas.1803615115">https://doi.org/10.1073/pnas.1803615115</a>
  chicago: Kotlobay, Alexey A., Karen Sarkisyan, Yuliana A. Mokrushina, Marina Marcet-Houben,
    Ekaterina O. Serebrovskaya, Nadezhda M. Markina, Louisa Gonzalez Somermeyer, et
    al. “Genetically Encodable Bioluminescent System from Fungi.” <i>Proceedings of
    the National Academy of Sciences of the United States of America</i>. National
    Academy of Sciences, 2018. <a href="https://doi.org/10.1073/pnas.1803615115">https://doi.org/10.1073/pnas.1803615115</a>.
  ieee: A. A. Kotlobay <i>et al.</i>, “Genetically encodable bioluminescent system
    from fungi,” <i>Proceedings of the National Academy of Sciences of the United
    States of America</i>, vol. 115, no. 50. National Academy of Sciences, pp. 12728–12732,
    2018.
  ista: Kotlobay AA, Sarkisyan K, Mokrushina YA, Marcet-Houben M, Serebrovskaya EO,
    Markina NM, Gonzalez Somermeyer L, Gorokhovatsky AY, Vvedensky A, Purtov KV, Petushkov
    VN, Rodionova NS, Chepurnyh TV, Fakhranurova L, Guglya EB, Ziganshin R, Tsarkova
    AS, Kaskova ZM, Shender V, Abakumov M, Abakumova TO, Povolotskaya IS, Eroshkin
    FM, Zaraisky AG, Mishin AS, Dolgov SV, Mitiouchkina TY, Kopantzev EP, Waldenmaier
    HE, Oliveira AG, Oba Y, Barsova E, Bogdanova EA, Gabaldón T, Stevani CV, Lukyanov
    S, Smirnov IV, Gitelson JI, Kondrashov F, Yampolsky IV. 2018. Genetically encodable
    bioluminescent system from fungi. Proceedings of the National Academy of Sciences
    of the United States of America. 115(50), 12728–12732.
  mla: Kotlobay, Alexey A., et al. “Genetically Encodable Bioluminescent System from
    Fungi.” <i>Proceedings of the National Academy of Sciences of the United States
    of America</i>, vol. 115, no. 50, National Academy of Sciences, 2018, pp. 12728–32,
    doi:<a href="https://doi.org/10.1073/pnas.1803615115">10.1073/pnas.1803615115</a>.
  short: A.A. Kotlobay, K. Sarkisyan, Y.A. Mokrushina, M. Marcet-Houben, E.O. Serebrovskaya,
    N.M. Markina, L. Gonzalez Somermeyer, A.Y. Gorokhovatsky, A. Vvedensky, K.V. Purtov,
    V.N. Petushkov, N.S. Rodionova, T.V. Chepurnyh, L. Fakhranurova, E.B. Guglya,
    R. Ziganshin, A.S. Tsarkova, Z.M. Kaskova, V. Shender, M. Abakumov, T.O. Abakumova,
    I.S. Povolotskaya, F.M. Eroshkin, A.G. Zaraisky, A.S. Mishin, S.V. Dolgov, T.Y.
    Mitiouchkina, E.P. Kopantzev, H.E. Waldenmaier, A.G. Oliveira, Y. Oba, E. Barsova,
    E.A. Bogdanova, T. Gabaldón, C.V. Stevani, S. Lukyanov, I.V. Smirnov, J.I. Gitelson,
    F. Kondrashov, I.V. Yampolsky, Proceedings of the National Academy of Sciences
    of the United States of America 115 (2018) 12728–12732.
date_created: 2018-12-23T22:59:18Z
date_published: 2018-12-11T00:00:00Z
date_updated: 2023-09-11T14:04:05Z
day: '11'
ddc:
- '580'
department:
- _id: FyKo
doi: 10.1073/pnas.1803615115
external_id:
  isi:
  - '000452866000068'
file:
- access_level: open_access
  checksum: 46b2c12185eb2ddb598f4c7b4bd267bf
  content_type: application/pdf
  creator: dernst
  date_created: 2019-02-05T15:21:40Z
  date_updated: 2020-07-14T12:47:11Z
  file_id: '5926'
  file_name: 2018_PNAS_Kotlobay.pdf
  file_size: 1271988
  relation: main_file
file_date_updated: 2020-07-14T12:47:11Z
has_accepted_license: '1'
intvolume: '       115'
isi: 1
issue: '50'
language:
- iso: eng
month: '12'
oa: 1
oa_version: Published Version
page: 12728-12732
publication: Proceedings of the National Academy of Sciences of the United States
  of America
publication_identifier:
  issn:
  - '00278424'
publication_status: published
publisher: National Academy of Sciences
quality_controlled: '1'
scopus_import: '1'
status: public
title: Genetically encodable bioluminescent system from fungi
tmp:
  image: /images/cc_by_nc_nd.png
  legal_code_url: https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode
  name: Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
    (CC BY-NC-ND 4.0)
  short: CC BY-NC-ND (4.0)
type: journal_article
user_id: c635000d-4b10-11ee-a964-aac5a93f6ac1
volume: 115
year: '2018'
...
---
_id: '5787'
abstract:
- lang: eng
  text: "Branching  morphogenesis  remains  a  subject  of  abiding  interest.  Although
    \ much  is  \r\nknown about the gene regulatory programs and signaling pathways
    that operate at \r\nthe cellular scale, it has remained unclear how the macroscopic
    features of branched \r\norgans,  including  their  size,  network  topology  and
    \ spatial  patterning,  are  encoded.  \r\nLately, it has been proposed that,
    these features can be explained quantitatively in \r\nseveral organs within a
    single unifying framework. Based on large-\r\nscale organ recon\r\n-\r\nstructions
    \ and  cell  lineage  tracing,  it  has  been  argued  that  morphogenesis  follows
    \ \r\nfrom the collective dynamics of sublineage- \r\nrestricted self- \r\nrenewing
    progenitor cells, \r\nlocalized at ductal tips, that act cooperatively to drive
    a serial process of ductal elon\r\n-\r\ngation and stochastic tip bifurcation.
    By correlating differentiation or cell cycle exit \r\nwith proximity to maturing
    ducts, this dynamic results in the specification of a com-\r\nplex  network  of
    \ defined  density  and  statistical  organization.  These  results  suggest  \r\nthat,
    for several mammalian tissues, branched epithelial structures develop as a self-
    \r\norganized  process,  reliant  upon  a  strikingly  simple,  but  generic,
    \ set  of  local  rules,  \r\nwithout  recourse  to  a  rigid  and  deterministic
    \ sequence  of  genetically  programmed  \r\nevents. Here, we review the basis
    of these findings and discuss their implications."
article_processing_charge: No
author:
- first_name: Edouard B
  full_name: Hannezo, Edouard B
  id: 3A9DB764-F248-11E8-B48F-1D18A9856A87
  last_name: Hannezo
  orcid: 0000-0001-6005-1561
- first_name: Benjamin D.
  full_name: Simons, Benjamin D.
  last_name: Simons
citation:
  ama: Hannezo EB, Simons BD. Statistical theory of branching morphogenesis. <i>Development
    Growth and Differentiation</i>. 2018;60(9):512-521. doi:<a href="https://doi.org/10.1111/dgd.12570">10.1111/dgd.12570</a>
  apa: Hannezo, E. B., &#38; Simons, B. D. (2018). Statistical theory of branching
    morphogenesis. <i>Development Growth and Differentiation</i>. Wiley. <a href="https://doi.org/10.1111/dgd.12570">https://doi.org/10.1111/dgd.12570</a>
  chicago: Hannezo, Edouard B, and Benjamin D. Simons. “Statistical Theory of Branching
    Morphogenesis.” <i>Development Growth and Differentiation</i>. Wiley, 2018. <a
    href="https://doi.org/10.1111/dgd.12570">https://doi.org/10.1111/dgd.12570</a>.
  ieee: E. B. Hannezo and B. D. Simons, “Statistical theory of branching morphogenesis,”
    <i>Development Growth and Differentiation</i>, vol. 60, no. 9. Wiley, pp. 512–521,
    2018.
  ista: Hannezo EB, Simons BD. 2018. Statistical theory of branching morphogenesis.
    Development Growth and Differentiation. 60(9), 512–521.
  mla: Hannezo, Edouard B., and Benjamin D. Simons. “Statistical Theory of Branching
    Morphogenesis.” <i>Development Growth and Differentiation</i>, vol. 60, no. 9,
    Wiley, 2018, pp. 512–21, doi:<a href="https://doi.org/10.1111/dgd.12570">10.1111/dgd.12570</a>.
  short: E.B. Hannezo, B.D. Simons, Development Growth and Differentiation 60 (2018)
    512–521.
date_created: 2018-12-30T22:59:14Z
date_published: 2018-12-09T00:00:00Z
date_updated: 2023-09-19T09:32:49Z
day: '09'
ddc:
- '570'
department:
- _id: EdHa
doi: 10.1111/dgd.12570
external_id:
  isi:
  - '000453555100002'
file:
- access_level: open_access
  checksum: a6d30b0785db902c734a84fecb2eadd9
  content_type: application/pdf
  creator: dernst
  date_created: 2019-02-06T10:40:46Z
  date_updated: 2020-07-14T12:47:11Z
  file_id: '5933'
  file_name: 2018_DevGrowh_Hannezo.pdf
  file_size: 1313606
  relation: main_file
file_date_updated: 2020-07-14T12:47:11Z
has_accepted_license: '1'
intvolume: '        60'
isi: 1
issue: '9'
language:
- iso: eng
month: '12'
oa: 1
oa_version: Published Version
page: 512-521
publication: Development Growth and Differentiation
publication_identifier:
  issn:
  - '00121592'
publisher: Wiley
quality_controlled: '1'
scopus_import: '1'
status: public
title: Statistical theory of branching morphogenesis
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: c635000d-4b10-11ee-a964-aac5a93f6ac1
volume: 60
year: '2018'
...
---
_id: '5788'
abstract:
- lang: eng
  text: In two-player games on graphs, the players move a token through a graph to
    produce an infinite path, which determines the winner or payoff of the game. Such
    games are central in formal verification since they model the interaction between
    a non-terminating system and its environment. We study bidding games in which
    the players bid for the right to move the token. Two bidding rules have been defined.
    In Richman bidding, in each round, the players simultaneously submit bids, and
    the higher bidder moves the token and pays the other player. Poorman bidding is
    similar except that the winner of the bidding pays the “bank” rather than the
    other player. While poorman reachability games have been studied before, we present,
    for the first time, results on infinite-duration poorman games. A central quantity
    in these games is the ratio between the two players’ initial budgets. The questions
    we study concern a necessary and sufficient ratio with which a player can achieve
    a goal. For reachability objectives, such threshold ratios are known to exist
    for both bidding rules. We show that the properties of poorman reachability games
    extend to complex qualitative objectives such as parity, similarly to the Richman
    case. Our most interesting results concern quantitative poorman games, namely
    poorman mean-payoff games, where we construct optimal strategies depending on
    the initial ratio, by showing a connection with random-turn based games. The connection
    in itself is interesting, because it does not hold for reachability poorman games.
    We also solve the complexity problems that arise in poorman bidding games.
alternative_title:
- LNCS
article_processing_charge: No
arxiv: 1
author:
- first_name: Guy
  full_name: Avni, Guy
  id: 463C8BC2-F248-11E8-B48F-1D18A9856A87
  last_name: Avni
  orcid: 0000-0001-5588-8287
- first_name: Thomas A
  full_name: Henzinger, Thomas A
  id: 40876CD8-F248-11E8-B48F-1D18A9856A87
  last_name: Henzinger
  orcid: 0000−0002−2985−7724
- first_name: Rasmus
  full_name: Ibsen-Jensen, Rasmus
  id: 3B699956-F248-11E8-B48F-1D18A9856A87
  last_name: Ibsen-Jensen
  orcid: 0000-0003-4783-0389
citation:
  ama: 'Avni G, Henzinger TA, Ibsen-Jensen R. Infinite-duration poorman-bidding games.
    In: Vol 11316. Springer; 2018:21-36. doi:<a href="https://doi.org/10.1007/978-3-030-04612-5_2">10.1007/978-3-030-04612-5_2</a>'
  apa: 'Avni, G., Henzinger, T. A., &#38; Ibsen-Jensen, R. (2018). Infinite-duration
    poorman-bidding games (Vol. 11316, pp. 21–36). Presented at the 14th International
    Conference on Web and Internet Economics, WINE, Oxford, UK: Springer. <a href="https://doi.org/10.1007/978-3-030-04612-5_2">https://doi.org/10.1007/978-3-030-04612-5_2</a>'
  chicago: Avni, Guy, Thomas A Henzinger, and Rasmus Ibsen-Jensen. “Infinite-Duration
    Poorman-Bidding Games,” 11316:21–36. Springer, 2018. <a href="https://doi.org/10.1007/978-3-030-04612-5_2">https://doi.org/10.1007/978-3-030-04612-5_2</a>.
  ieee: G. Avni, T. A. Henzinger, and R. Ibsen-Jensen, “Infinite-duration poorman-bidding
    games,” presented at the 14th International Conference on Web and Internet Economics,
    WINE, Oxford, UK, 2018, vol. 11316, pp. 21–36.
  ista: Avni G, Henzinger TA, Ibsen-Jensen R. 2018. Infinite-duration poorman-bidding
    games. 14th International Conference on Web and Internet Economics, WINE, LNCS,
    vol. 11316, 21–36.
  mla: Avni, Guy, et al. <i>Infinite-Duration Poorman-Bidding Games</i>. Vol. 11316,
    Springer, 2018, pp. 21–36, doi:<a href="https://doi.org/10.1007/978-3-030-04612-5_2">10.1007/978-3-030-04612-5_2</a>.
  short: G. Avni, T.A. Henzinger, R. Ibsen-Jensen, in:, Springer, 2018, pp. 21–36.
conference:
  end_date: 2018-12-17
  location: Oxford, UK
  name: 14th International Conference on Web and Internet Economics, WINE
  start_date: 2018-12-15
date_created: 2018-12-30T22:59:14Z
date_published: 2018-11-21T00:00:00Z
date_updated: 2023-09-12T07:44:01Z
day: '21'
department:
- _id: ToHe
doi: 10.1007/978-3-030-04612-5_2
external_id:
  arxiv:
  - '1804.04372'
  isi:
  - '000865933000002'
intvolume: '     11316'
isi: 1
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://arxiv.org/abs/1804.04372
month: '11'
oa: 1
oa_version: Preprint
page: 21-36
project:
- _id: 25F42A32-B435-11E9-9278-68D0E5697425
  call_identifier: FWF
  grant_number: Z211
  name: The Wittgenstein Prize
- _id: 25832EC2-B435-11E9-9278-68D0E5697425
  call_identifier: FWF
  grant_number: S 11407_N23
  name: Rigorous Systems Engineering
- _id: 264B3912-B435-11E9-9278-68D0E5697425
  call_identifier: FWF
  grant_number: M02369
  name: Formal Methods meets Algorithmic Game Theory
publication_identifier:
  isbn:
  - '9783030046118'
  issn:
  - '03029743'
publisher: Springer
quality_controlled: '1'
scopus_import: '1'
status: public
title: Infinite-duration poorman-bidding games
type: conference
user_id: c635000d-4b10-11ee-a964-aac5a93f6ac1
volume: 11316
year: '2018'
...
---
_id: '5791'
abstract:
- lang: eng
  text: Due to data compression or low resolution, nearby vertices and edges of a
    graph drawing may be bundled to a common node or arc. We model such a “compromised”
    drawing by a piecewise linear map φ:G → ℝ. We wish to perturb φ by an arbitrarily
    small ε>0 into a proper drawing (in which the vertices are distinct points, any
    two edges intersect in finitely many points, and no three edges have a common
    interior point) that minimizes the number of crossings. An ε-perturbation, for
    every ε>0, is given by a piecewise linear map (Formula Presented), where with
    ||·|| is the uniform norm (i.e., sup norm). We present a polynomial-time solution
    for this optimization problem when G is a cycle and the map φ has no spurs (i.e.,
    no two adjacent edges are mapped to overlapping arcs). We also show that the problem
    becomes NP-complete (i) when G is an arbitrary graph and φ has no spurs, and (ii)
    when φ may have spurs and G is a cycle or a union of disjoint paths.
alternative_title:
- LNCS
article_processing_charge: No
arxiv: 1
author:
- first_name: Radoslav
  full_name: Fulek, Radoslav
  id: 39F3FFE4-F248-11E8-B48F-1D18A9856A87
  last_name: Fulek
  orcid: 0000-0001-8485-1774
- first_name: Csaba D.
  full_name: Tóth, Csaba D.
  last_name: Tóth
citation:
  ama: 'Fulek R, Tóth CD. Crossing minimization in perturbed drawings. In: Vol 11282.
    Springer; 2018:229-241. doi:<a href="https://doi.org/10.1007/978-3-030-04414-5_16">10.1007/978-3-030-04414-5_16</a>'
  apa: 'Fulek, R., &#38; Tóth, C. D. (2018). Crossing minimization in perturbed drawings
    (Vol. 11282, pp. 229–241). Presented at the Graph Drawing and Network Visualization,
    Barcelona, Spain: Springer. <a href="https://doi.org/10.1007/978-3-030-04414-5_16">https://doi.org/10.1007/978-3-030-04414-5_16</a>'
  chicago: Fulek, Radoslav, and Csaba D. Tóth. “Crossing Minimization in Perturbed
    Drawings,” 11282:229–41. Springer, 2018. <a href="https://doi.org/10.1007/978-3-030-04414-5_16">https://doi.org/10.1007/978-3-030-04414-5_16</a>.
  ieee: R. Fulek and C. D. Tóth, “Crossing minimization in perturbed drawings,” presented
    at the Graph Drawing and Network Visualization, Barcelona, Spain, 2018, vol. 11282,
    pp. 229–241.
  ista: Fulek R, Tóth CD. 2018. Crossing minimization in perturbed drawings. Graph
    Drawing and Network Visualization, LNCS, vol. 11282, 229–241.
  mla: Fulek, Radoslav, and Csaba D. Tóth. <i>Crossing Minimization in Perturbed Drawings</i>.
    Vol. 11282, Springer, 2018, pp. 229–41, doi:<a href="https://doi.org/10.1007/978-3-030-04414-5_16">10.1007/978-3-030-04414-5_16</a>.
  short: R. Fulek, C.D. Tóth, in:, Springer, 2018, pp. 229–241.
conference:
  end_date: 2018-09-28
  location: Barcelona, Spain
  name: Graph Drawing and Network Visualization
  start_date: 2018-09-26
date_created: 2018-12-30T22:59:15Z
date_published: 2018-12-18T00:00:00Z
date_updated: 2023-09-11T12:49:55Z
day: '18'
department:
- _id: UlWa
doi: 10.1007/978-3-030-04414-5_16
external_id:
  arxiv:
  - '1808.07608'
  isi:
  - '000672802500016'
isi: 1
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://arxiv.org/abs/1808.07608
month: '12'
oa: 1
oa_version: Preprint
page: 229-241
publication_identifier:
  isbn:
  - '9783030044138'
publication_status: published
publisher: Springer
quality_controlled: '1'
scopus_import: '1'
status: public
title: Crossing minimization in perturbed drawings
type: conference
user_id: c635000d-4b10-11ee-a964-aac5a93f6ac1
volume: '11282 '
year: '2018'
...
---
_id: '5794'
abstract:
- lang: eng
  text: We present an approach to interacting quantum many-body systems based on the
    notion of quantum groups, also known as q-deformed Lie algebras. In particular,
    we show that, if the symmetry of a free quantum particle corresponds to a Lie
    group G, in the presence of a many-body environment this particle can be described
    by a deformed group, Gq. Crucially, the single deformation parameter, q, contains
    all the information about the many-particle interactions in the system. We exemplify
    our approach by considering a quantum rotor interacting with a bath of bosons,
    and demonstrate that extracting the value of q from closed-form solutions in the
    perturbative regime allows one to predict the behavior of the system for arbitrary
    values of the impurity-bath coupling strength, in good agreement with nonperturbative
    calculations. Furthermore, the value of the deformation parameter allows one to
    predict at which coupling strengths rotor-bath interactions result in a formation
    of a stable quasiparticle. The approach based on quantum groups does not only
    allow for a drastic simplification of impurity problems, but also provides valuable
    insights into hidden symmetries of interacting many-particle systems.
article_number: '255302'
article_processing_charge: No
article_type: original
arxiv: 1
author:
- first_name: Enderalp
  full_name: Yakaboylu, Enderalp
  id: 38CB71F6-F248-11E8-B48F-1D18A9856A87
  last_name: Yakaboylu
  orcid: 0000-0001-5973-0874
- first_name: Mikhail
  full_name: Shkolnikov, Mikhail
  id: 35084A62-F248-11E8-B48F-1D18A9856A87
  last_name: Shkolnikov
  orcid: 0000-0002-4310-178X
- first_name: Mikhail
  full_name: Lemeshko, Mikhail
  id: 37CB05FA-F248-11E8-B48F-1D18A9856A87
  last_name: Lemeshko
  orcid: 0000-0002-6990-7802
citation:
  ama: Yakaboylu E, Shkolnikov M, Lemeshko M. Quantum groups as hidden symmetries
    of quantum impurities. <i>Physical Review Letters</i>. 2018;121(25). doi:<a href="https://doi.org/10.1103/PhysRevLett.121.255302">10.1103/PhysRevLett.121.255302</a>
  apa: Yakaboylu, E., Shkolnikov, M., &#38; Lemeshko, M. (2018). Quantum groups as
    hidden symmetries of quantum impurities. <i>Physical Review Letters</i>. American
    Physical Society. <a href="https://doi.org/10.1103/PhysRevLett.121.255302">https://doi.org/10.1103/PhysRevLett.121.255302</a>
  chicago: Yakaboylu, Enderalp, Mikhail Shkolnikov, and Mikhail Lemeshko. “Quantum
    Groups as Hidden Symmetries of Quantum Impurities.” <i>Physical Review Letters</i>.
    American Physical Society, 2018. <a href="https://doi.org/10.1103/PhysRevLett.121.255302">https://doi.org/10.1103/PhysRevLett.121.255302</a>.
  ieee: E. Yakaboylu, M. Shkolnikov, and M. Lemeshko, “Quantum groups as hidden symmetries
    of quantum impurities,” <i>Physical Review Letters</i>, vol. 121, no. 25. American
    Physical Society, 2018.
  ista: Yakaboylu E, Shkolnikov M, Lemeshko M. 2018. Quantum groups as hidden symmetries
    of quantum impurities. Physical Review Letters. 121(25), 255302.
  mla: Yakaboylu, Enderalp, et al. “Quantum Groups as Hidden Symmetries of Quantum
    Impurities.” <i>Physical Review Letters</i>, vol. 121, no. 25, 255302, American
    Physical Society, 2018, doi:<a href="https://doi.org/10.1103/PhysRevLett.121.255302">10.1103/PhysRevLett.121.255302</a>.
  short: E. Yakaboylu, M. Shkolnikov, M. Lemeshko, Physical Review Letters 121 (2018).
date_created: 2019-01-06T22:59:12Z
date_published: 2018-12-17T00:00:00Z
date_updated: 2023-09-15T12:09:06Z
day: '17'
department:
- _id: MiLe
doi: 10.1103/PhysRevLett.121.255302
ec_funded: 1
external_id:
  arxiv:
  - '1809.00222'
  isi:
  - '000454178600009'
intvolume: '       121'
isi: 1
issue: '25'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://arxiv.org/abs/1809.00222
month: '12'
oa: 1
oa_version: Preprint
project:
- _id: 25681D80-B435-11E9-9278-68D0E5697425
  call_identifier: FP7
  grant_number: '291734'
  name: International IST Postdoc Fellowship Programme
- _id: 26031614-B435-11E9-9278-68D0E5697425
  call_identifier: FWF
  grant_number: P29902
  name: Quantum rotations in the presence of a many-body environment
publication: Physical Review Letters
publication_identifier:
  issn:
  - '00319007'
publication_status: published
publisher: American Physical Society
quality_controlled: '1'
scopus_import: '1'
status: public
title: Quantum groups as hidden symmetries of quantum impurities
type: journal_article
user_id: c635000d-4b10-11ee-a964-aac5a93f6ac1
volume: 121
year: '2018'
...
---
_id: '58'
abstract:
- lang: eng
  text: 'Inside a two-dimensional region (``cake&quot;&quot;), there are m nonoverlapping
    tiles of a certain kind (``toppings&quot;&quot;). We want to expand the toppings
    while keeping them nonoverlapping, and possibly add some blank pieces of the same
    ``certain kind,&quot;&quot; such that the entire cake is covered. How many blanks
    must we add? We study this question in several cases: (1) The cake and toppings
    are general polygons. (2) The cake and toppings are convex figures. (3) The cake
    and toppings are axis-parallel rectangles. (4) The cake is an axis-parallel rectilinear
    polygon and the toppings are axis-parallel rectangles. In all four cases, we provide
    tight bounds on the number of blanks.'
article_processing_charge: No
arxiv: 1
author:
- first_name: Arseniy
  full_name: Akopyan, Arseniy
  id: 430D2C90-F248-11E8-B48F-1D18A9856A87
  last_name: Akopyan
  orcid: 0000-0002-2548-617X
- first_name: Erel
  full_name: Segal Halevi, Erel
  last_name: Segal Halevi
citation:
  ama: Akopyan A, Segal Halevi E. Counting blanks in polygonal arrangements. <i>SIAM
    Journal on Discrete Mathematics</i>. 2018;32(3):2242-2257. doi:<a href="https://doi.org/10.1137/16M110407X">10.1137/16M110407X</a>
  apa: Akopyan, A., &#38; Segal Halevi, E. (2018). Counting blanks in polygonal arrangements.
    <i>SIAM Journal on Discrete Mathematics</i>. Society for Industrial and Applied
    Mathematics . <a href="https://doi.org/10.1137/16M110407X">https://doi.org/10.1137/16M110407X</a>
  chicago: Akopyan, Arseniy, and Erel Segal Halevi. “Counting Blanks in Polygonal
    Arrangements.” <i>SIAM Journal on Discrete Mathematics</i>. Society for Industrial
    and Applied Mathematics , 2018. <a href="https://doi.org/10.1137/16M110407X">https://doi.org/10.1137/16M110407X</a>.
  ieee: A. Akopyan and E. Segal Halevi, “Counting blanks in polygonal arrangements,”
    <i>SIAM Journal on Discrete Mathematics</i>, vol. 32, no. 3. Society for Industrial
    and Applied Mathematics , pp. 2242–2257, 2018.
  ista: Akopyan A, Segal Halevi E. 2018. Counting blanks in polygonal arrangements.
    SIAM Journal on Discrete Mathematics. 32(3), 2242–2257.
  mla: Akopyan, Arseniy, and Erel Segal Halevi. “Counting Blanks in Polygonal Arrangements.”
    <i>SIAM Journal on Discrete Mathematics</i>, vol. 32, no. 3, Society for Industrial
    and Applied Mathematics , 2018, pp. 2242–57, doi:<a href="https://doi.org/10.1137/16M110407X">10.1137/16M110407X</a>.
  short: A. Akopyan, E. Segal Halevi, SIAM Journal on Discrete Mathematics 32 (2018)
    2242–2257.
date_created: 2018-12-11T11:44:24Z
date_published: 2018-09-06T00:00:00Z
date_updated: 2023-09-11T12:48:39Z
day: '06'
department:
- _id: HeEd
doi: 10.1137/16M110407X
ec_funded: 1
external_id:
  arxiv:
  - '1604.00960'
  isi:
  - '000450810500036'
intvolume: '        32'
isi: 1
issue: '3'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://arxiv.org/abs/1604.00960
month: '09'
oa: 1
oa_version: Preprint
page: 2242 - 2257
project:
- _id: 25681D80-B435-11E9-9278-68D0E5697425
  call_identifier: FP7
  grant_number: '291734'
  name: International IST Postdoc Fellowship Programme
publication: SIAM Journal on Discrete Mathematics
publication_status: published
publisher: 'Society for Industrial and Applied Mathematics '
publist_id: '7996'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Counting blanks in polygonal arrangements
type: journal_article
user_id: c635000d-4b10-11ee-a964-aac5a93f6ac1
volume: 32
year: '2018'
...
---
_id: '5816'
abstract:
- lang: eng
  text: Solid-state qubit manipulation and read-out fidelities are reaching fault-tolerance,
    but quantum error correction requires millions of physical qubits and therefore
    a scalable quantum computer architecture. To solve signal-line bandwidth and fan-out
    problems, microwave sources required for qubit manipulation might be embedded
    close to the qubit chip, typically operating at temperatures below 4 K. Here,
    we perform the first low temperature measurements of a 130 nm BiCMOS based SiGe
    voltage controlled oscillator at cryogenic temperature. We determined the frequency
    and output power dependence on temperature and magnetic field up to 5 T and measured
    the temperature influence on its noise performance. The device maintains its full
    functionality from 300 K to 4 K. The carrier frequency at 4 K increases by 3%
    with respect to the carrier frequency at 300 K, and the output power at 4 K increases
    by 10 dB relative to the output power at 300 K. The frequency tuning range of
    approximately 20% remains unchanged between 300 K and 4 K. In an in-plane magnetic
    field of 5 T, the carrier frequency shifts by only 0.02% compared to the frequency
    at zero magnetic field.
article_number: '114701'
article_processing_charge: No
arxiv: 1
author:
- first_name: Arne
  full_name: Hollmann, Arne
  last_name: Hollmann
- first_name: Daniel
  full_name: Jirovec, Daniel
  id: 4C473F58-F248-11E8-B48F-1D18A9856A87
  last_name: Jirovec
  orcid: 0000-0002-7197-4801
- first_name: Maciej
  full_name: Kucharski, Maciej
  last_name: Kucharski
- first_name: Dietmar
  full_name: Kissinger, Dietmar
  last_name: Kissinger
- first_name: Gunter
  full_name: Fischer, Gunter
  last_name: Fischer
- first_name: Lars R.
  full_name: Schreiber, Lars R.
  last_name: Schreiber
citation:
  ama: Hollmann A, Jirovec D, Kucharski M, Kissinger D, Fischer G, Schreiber LR. 30
    GHz-voltage controlled oscillator operating at 4 K. <i>Review of Scientific Instruments</i>.
    2018;89(11). doi:<a href="https://doi.org/10.1063/1.5038258">10.1063/1.5038258</a>
  apa: Hollmann, A., Jirovec, D., Kucharski, M., Kissinger, D., Fischer, G., &#38;
    Schreiber, L. R. (2018). 30 GHz-voltage controlled oscillator operating at 4 K.
    <i>Review of Scientific Instruments</i>. AIP Publishing. <a href="https://doi.org/10.1063/1.5038258">https://doi.org/10.1063/1.5038258</a>
  chicago: Hollmann, Arne, Daniel Jirovec, Maciej Kucharski, Dietmar Kissinger, Gunter
    Fischer, and Lars R. Schreiber. “30 GHz-Voltage Controlled Oscillator Operating
    at 4 K.” <i>Review of Scientific Instruments</i>. AIP Publishing, 2018. <a href="https://doi.org/10.1063/1.5038258">https://doi.org/10.1063/1.5038258</a>.
  ieee: A. Hollmann, D. Jirovec, M. Kucharski, D. Kissinger, G. Fischer, and L. R.
    Schreiber, “30 GHz-voltage controlled oscillator operating at 4 K,” <i>Review
    of Scientific Instruments</i>, vol. 89, no. 11. AIP Publishing, 2018.
  ista: Hollmann A, Jirovec D, Kucharski M, Kissinger D, Fischer G, Schreiber LR.
    2018. 30 GHz-voltage controlled oscillator operating at 4 K. Review of Scientific
    Instruments. 89(11), 114701.
  mla: Hollmann, Arne, et al. “30 GHz-Voltage Controlled Oscillator Operating at 4
    K.” <i>Review of Scientific Instruments</i>, vol. 89, no. 11, 114701, AIP Publishing,
    2018, doi:<a href="https://doi.org/10.1063/1.5038258">10.1063/1.5038258</a>.
  short: A. Hollmann, D. Jirovec, M. Kucharski, D. Kissinger, G. Fischer, L.R. Schreiber,
    Review of Scientific Instruments 89 (2018).
date_created: 2019-01-10T14:22:23Z
date_published: 2018-11-01T00:00:00Z
date_updated: 2024-03-25T23:30:14Z
day: '01'
department:
- _id: GeKa
doi: 10.1063/1.5038258
external_id:
  arxiv:
  - '1804.09522'
  isi:
  - '000451735700054'
intvolume: '        89'
isi: 1
issue: '11'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://arxiv.org/abs/1804.09522
month: '11'
oa: 1
oa_version: Preprint
publication: Review of Scientific Instruments
publication_identifier:
  issn:
  - '00346748'
publication_status: published
publisher: AIP Publishing
quality_controlled: '1'
related_material:
  record:
  - id: '10058'
    relation: dissertation_contains
    status: public
scopus_import: '1'
status: public
title: 30 GHz-voltage controlled oscillator operating at 4 K
type: journal_article
user_id: c635000d-4b10-11ee-a964-aac5a93f6ac1
volume: 89
year: '2018'
...
---
_id: '5830'
abstract:
- lang: eng
  text: CLE peptides have been implicated in various developmental processes of plants
    and mediate their responses to environmental stimuli. However, the biological
    relevance of most CLE genes remains to be functionally characterized. Here, we
    report that CLE9, which is expressed in stomata, acts as an essential regulator
    in the induction of stomatal closure. Exogenous application of CLE9 peptides or
    overexpression of CLE9 effectively led to stomatal closure and enhanced drought
    tolerance, whereas CLE9 loss-of-function mutants were sensitivity to drought stress.
    CLE9-induced stomatal closure was impaired in abscisic acid (ABA)-deficient mutants,
    indicating that ABA is required for CLE9-medaited guard cell signalling. We further
    deciphered that two guard cell ABA-signalling components, OST1 and SLAC1, were
    responsible for CLE9-induced stomatal closure. MPK3 and MPK6 were activated by
    the CLE9 peptide, and CLE9 peptides failed to close stomata in mpk3 and mpk6 mutants.
    In addition, CLE9 peptides stimulated the induction of hydrogen peroxide (H2O2)
    and nitric oxide (NO) synthesis associated with stomatal closure, which was abolished
    in the NADPH oxidase-deficient mutants or nitric reductase mutants, respectively.
    Collectively, our results reveal a novel ABA-dependent function of CLE9 in the
    regulation of stomatal apertures, thereby suggesting a potential role of CLE9
    in the stress acclimatization of plants.
article_processing_charge: No
author:
- first_name: Luosha
  full_name: Zhang, Luosha
  last_name: Zhang
- first_name: Xiong
  full_name: Shi, Xiong
  last_name: Shi
- first_name: Yutao
  full_name: Zhang, Yutao
  last_name: Zhang
- first_name: Jiajing
  full_name: Wang, Jiajing
  last_name: Wang
- first_name: Jingwei
  full_name: Yang, Jingwei
  last_name: Yang
- first_name: Takashi
  full_name: Ishida, Takashi
  last_name: Ishida
- first_name: Wenqian
  full_name: Jiang, Wenqian
  last_name: Jiang
- first_name: Xiangyu
  full_name: Han, Xiangyu
  last_name: Han
- first_name: Jingke
  full_name: Kang, Jingke
  last_name: Kang
- first_name: Xuening
  full_name: Wang, Xuening
  last_name: Wang
- first_name: Lixia
  full_name: Pan, Lixia
  last_name: Pan
- first_name: Shuo
  full_name: Lv, Shuo
  last_name: Lv
- first_name: Bing
  full_name: Cao, Bing
  last_name: Cao
- first_name: Yonghong
  full_name: Zhang, Yonghong
  last_name: Zhang
- first_name: Jinbin
  full_name: Wu, Jinbin
  last_name: Wu
- first_name: Huibin
  full_name: Han, Huibin
  id: 31435098-F248-11E8-B48F-1D18A9856A87
  last_name: Han
- first_name: Zhubing
  full_name: Hu, Zhubing
  last_name: Hu
- first_name: Langjun
  full_name: Cui, Langjun
  last_name: Cui
- first_name: Shinichiro
  full_name: Sawa, Shinichiro
  last_name: Sawa
- first_name: Junmin
  full_name: He, Junmin
  last_name: He
- first_name: Guodong
  full_name: Wang, Guodong
  last_name: Wang
citation:
  ama: Zhang L, Shi X, Zhang Y, et al. CLE9 peptide-induced stomatal closure is mediated
    by abscisic acid, hydrogen peroxide, and nitric oxide in arabidopsis thaliana.
    <i>Plant Cell and Environment</i>. 2018. doi:<a href="https://doi.org/10.1111/pce.13475">10.1111/pce.13475</a>
  apa: Zhang, L., Shi, X., Zhang, Y., Wang, J., Yang, J., Ishida, T., … Wang, G. (2018).
    CLE9 peptide-induced stomatal closure is mediated by abscisic acid, hydrogen peroxide,
    and nitric oxide in arabidopsis thaliana. <i>Plant Cell and Environment</i>. Wiley.
    <a href="https://doi.org/10.1111/pce.13475">https://doi.org/10.1111/pce.13475</a>
  chicago: Zhang, Luosha, Xiong Shi, Yutao Zhang, Jiajing Wang, Jingwei Yang, Takashi
    Ishida, Wenqian Jiang, et al. “CLE9 Peptide-Induced Stomatal Closure Is Mediated
    by Abscisic Acid, Hydrogen Peroxide, and Nitric Oxide in Arabidopsis Thaliana.”
    <i>Plant Cell and Environment</i>. Wiley, 2018. <a href="https://doi.org/10.1111/pce.13475">https://doi.org/10.1111/pce.13475</a>.
  ieee: L. Zhang <i>et al.</i>, “CLE9 peptide-induced stomatal closure is mediated
    by abscisic acid, hydrogen peroxide, and nitric oxide in arabidopsis thaliana,”
    <i>Plant Cell and Environment</i>. Wiley, 2018.
  ista: Zhang L, Shi X, Zhang Y, Wang J, Yang J, Ishida T, Jiang W, Han X, Kang J,
    Wang X, Pan L, Lv S, Cao B, Zhang Y, Wu J, Han H, Hu Z, Cui L, Sawa S, He J, Wang
    G. 2018. CLE9 peptide-induced stomatal closure is mediated by abscisic acid, hydrogen
    peroxide, and nitric oxide in arabidopsis thaliana. Plant Cell and Environment.
  mla: Zhang, Luosha, et al. “CLE9 Peptide-Induced Stomatal Closure Is Mediated by
    Abscisic Acid, Hydrogen Peroxide, and Nitric Oxide in Arabidopsis Thaliana.” <i>Plant
    Cell and Environment</i>, Wiley, 2018, doi:<a href="https://doi.org/10.1111/pce.13475">10.1111/pce.13475</a>.
  short: L. Zhang, X. Shi, Y. Zhang, J. Wang, J. Yang, T. Ishida, W. Jiang, X. Han,
    J. Kang, X. Wang, L. Pan, S. Lv, B. Cao, Y. Zhang, J. Wu, H. Han, Z. Hu, L. Cui,
    S. Sawa, J. He, G. Wang, Plant Cell and Environment (2018).
date_created: 2019-01-13T22:59:11Z
date_published: 2018-10-31T00:00:00Z
date_updated: 2023-09-11T12:43:31Z
day: '31'
department:
- _id: JiFr
doi: 10.1111/pce.13475
external_id:
  isi:
  - '000459014800021'
  pmid:
  - '30378140'
isi: 1
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://www.ncbi.nlm.nih.gov/pubmed/30378140
month: '10'
oa: 1
oa_version: Published Version
pmid: 1
publication: Plant Cell and Environment
publication_identifier:
  issn:
  - '01407791'
publication_status: epub_ahead
publisher: Wiley
quality_controlled: '1'
scopus_import: '1'
status: public
title: CLE9 peptide-induced stomatal closure is mediated by abscisic acid, hydrogen
  peroxide, and nitric oxide in arabidopsis thaliana
type: journal_article
user_id: c635000d-4b10-11ee-a964-aac5a93f6ac1
year: '2018'
...
---
_id: '5858'
abstract:
- lang: eng
  text: Spatial patterns are ubiquitous on the subcellular, cellular and tissue level,
    and can be studied using imaging techniques such as light and fluorescence microscopy.
    Imaging data provide quantitative information about biological systems; however,
    mechanisms causing spatial patterning often remain elusive. In recent years, spatio-temporal
    mathematical modelling has helped to overcome this problem. Yet, outliers and
    structured noise limit modelling of whole imaging data, and models often consider
    spatial summary statistics. Here, we introduce an integrated data-driven modelling
    approach that can cope with measurement artefacts and whole imaging data. Our
    approach combines mechanistic models of the biological processes with robust statistical
    models of the measurement process. The parameters of the integrated model are
    calibrated using a maximum-likelihood approach. We used this integrated modelling
    approach to study in vivo gradients of the chemokine (C-C motif) ligand 21 (CCL21).
    CCL21 gradients guide dendritic cells and are important in the adaptive immune
    response. Using artificial data, we verified that the integrated modelling approach
    provides reliable parameter estimates in the presence of measurement noise and
    that bias and variance of these estimates are reduced compared to conventional
    approaches. The application to experimental data allowed the parametrization and
    subsequent refinement of the model using additional mechanisms. Among other results,
    model-based hypothesis testing predicted lymphatic vessel-dependent concentration
    of heparan sulfate, the binding partner of CCL21. The selected model provided
    an accurate description of the experimental data and was partially validated using
    published data. Our findings demonstrate that integrated statistical modelling
    of whole imaging data is computationally feasible and can provide novel biological
    insights.
article_number: '20180600'
article_processing_charge: No
author:
- first_name: Sabrina
  full_name: Hross, Sabrina
  last_name: Hross
- first_name: Fabian J.
  full_name: Theis, Fabian J.
  last_name: Theis
- first_name: Michael K
  full_name: Sixt, Michael K
  id: 41E9FBEA-F248-11E8-B48F-1D18A9856A87
  last_name: Sixt
  orcid: 0000-0002-6620-9179
- first_name: Jan
  full_name: Hasenauer, Jan
  last_name: Hasenauer
citation:
  ama: Hross S, Theis FJ, Sixt MK, Hasenauer J. Mechanistic description of spatial
    processes using integrative modelling of noise-corrupted imaging data. <i>Journal
    of the Royal Society Interface</i>. 2018;15(149). doi:<a href="https://doi.org/10.1098/rsif.2018.0600">10.1098/rsif.2018.0600</a>
  apa: Hross, S., Theis, F. J., Sixt, M. K., &#38; Hasenauer, J. (2018). Mechanistic
    description of spatial processes using integrative modelling of noise-corrupted
    imaging data. <i>Journal of the Royal Society Interface</i>. Royal Society Publishing.
    <a href="https://doi.org/10.1098/rsif.2018.0600">https://doi.org/10.1098/rsif.2018.0600</a>
  chicago: Hross, Sabrina, Fabian J. Theis, Michael K Sixt, and Jan Hasenauer. “Mechanistic
    Description of Spatial Processes Using Integrative Modelling of Noise-Corrupted
    Imaging Data.” <i>Journal of the Royal Society Interface</i>. Royal Society Publishing,
    2018. <a href="https://doi.org/10.1098/rsif.2018.0600">https://doi.org/10.1098/rsif.2018.0600</a>.
  ieee: S. Hross, F. J. Theis, M. K. Sixt, and J. Hasenauer, “Mechanistic description
    of spatial processes using integrative modelling of noise-corrupted imaging data,”
    <i>Journal of the Royal Society Interface</i>, vol. 15, no. 149. Royal Society
    Publishing, 2018.
  ista: Hross S, Theis FJ, Sixt MK, Hasenauer J. 2018. Mechanistic description of
    spatial processes using integrative modelling of noise-corrupted imaging data.
    Journal of the Royal Society Interface. 15(149), 20180600.
  mla: Hross, Sabrina, et al. “Mechanistic Description of Spatial Processes Using
    Integrative Modelling of Noise-Corrupted Imaging Data.” <i>Journal of the Royal
    Society Interface</i>, vol. 15, no. 149, 20180600, Royal Society Publishing, 2018,
    doi:<a href="https://doi.org/10.1098/rsif.2018.0600">10.1098/rsif.2018.0600</a>.
  short: S. Hross, F.J. Theis, M.K. Sixt, J. Hasenauer, Journal of the Royal Society
    Interface 15 (2018).
date_created: 2019-01-20T22:59:18Z
date_published: 2018-12-05T00:00:00Z
date_updated: 2023-09-13T08:55:05Z
day: '05'
ddc:
- '570'
department:
- _id: MiSi
doi: 10.1098/rsif.2018.0600
external_id:
  isi:
  - '000456783800011'
file:
- access_level: open_access
  checksum: 56eb4308a15b7190bff938fab1f780e8
  content_type: application/pdf
  creator: dernst
  date_created: 2019-02-05T14:46:44Z
  date_updated: 2020-07-14T12:47:13Z
  file_id: '5925'
  file_name: 2018_Interface_Hross.pdf
  file_size: 1464288
  relation: main_file
file_date_updated: 2020-07-14T12:47:13Z
has_accepted_license: '1'
intvolume: '        15'
isi: 1
issue: '149'
language:
- iso: eng
month: '12'
oa: 1
oa_version: Published Version
publication: Journal of the Royal Society Interface
publication_identifier:
  issn:
  - '17425689'
publication_status: published
publisher: Royal Society Publishing
quality_controlled: '1'
scopus_import: '1'
status: public
title: Mechanistic description of spatial processes using integrative modelling of
  noise-corrupted imaging data
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: c635000d-4b10-11ee-a964-aac5a93f6ac1
volume: 15
year: '2018'
...
---
_id: '5859'
abstract:
- lang: eng
  text: The emergence of syntax during childhood is a remarkable example of how complex
    correlations unfold in nonlinear ways through development. In particular, rapid
    transitions seem to occur as children reach the age of two, which seems to separate
    a two-word, tree-like network of syntactic relations among words from the scale-free
    graphs associated with the adult, complex grammar. Here, we explore the evolution
    of syntax networks through language acquisition using the chromatic number, which
    captures the transition and provides a natural link to standard theories on syntactic
    structures. The data analysis is compared to a null model of network growth dynamics
    which is shown to display non-trivial and sensible differences. At a more general
    level, we observe that the chromatic classes define independent regions of the
    graph, and thus, can be interpreted as the footprints of incompatibility relations,
    somewhat as opposed to modularity considerations.
acknowledgement: This work was supported by the James McDonnell Foundation (B.C-M.,
  S.V. and R.S.)
article_number: '181286'
article_processing_charge: No
article_type: original
author:
- first_name: Bernat
  full_name: Corominas-Murtra, Bernat
  id: 43BE2298-F248-11E8-B48F-1D18A9856A87
  last_name: Corominas-Murtra
  orcid: 0000-0001-9806-5643
- first_name: Martí Sànchez
  full_name: Fibla, Martí Sànchez
  last_name: Fibla
- first_name: Sergi
  full_name: Valverde, Sergi
  last_name: Valverde
- first_name: Ricard
  full_name: Solé, Ricard
  last_name: Solé
citation:
  ama: Corominas-Murtra B, Fibla MS, Valverde S, Solé R. Chromatic transitions in
    the emergence of syntax networks. <i>Royal Society Open Science</i>. 2018;5(12).
    doi:<a href="https://doi.org/10.1098/rsos.181286">10.1098/rsos.181286</a>
  apa: Corominas-Murtra, B., Fibla, M. S., Valverde, S., &#38; Solé, R. (2018). Chromatic
    transitions in the emergence of syntax networks. <i>Royal Society Open Science</i>.
    The Royal Society. <a href="https://doi.org/10.1098/rsos.181286">https://doi.org/10.1098/rsos.181286</a>
  chicago: Corominas-Murtra, Bernat, Martí Sànchez Fibla, Sergi Valverde, and Ricard
    Solé. “Chromatic Transitions in the Emergence of Syntax Networks.” <i>Royal Society
    Open Science</i>. The Royal Society, 2018. <a href="https://doi.org/10.1098/rsos.181286">https://doi.org/10.1098/rsos.181286</a>.
  ieee: B. Corominas-Murtra, M. S. Fibla, S. Valverde, and R. Solé, “Chromatic transitions
    in the emergence of syntax networks,” <i>Royal Society Open Science</i>, vol.
    5, no. 12. The Royal Society, 2018.
  ista: Corominas-Murtra B, Fibla MS, Valverde S, Solé R. 2018. Chromatic transitions
    in the emergence of syntax networks. Royal Society Open Science. 5(12), 181286.
  mla: Corominas-Murtra, Bernat, et al. “Chromatic Transitions in the Emergence of
    Syntax Networks.” <i>Royal Society Open Science</i>, vol. 5, no. 12, 181286, The
    Royal Society, 2018, doi:<a href="https://doi.org/10.1098/rsos.181286">10.1098/rsos.181286</a>.
  short: B. Corominas-Murtra, M.S. Fibla, S. Valverde, R. Solé, Royal Society Open
    Science 5 (2018).
date_created: 2019-01-20T22:59:18Z
date_published: 2018-12-12T00:00:00Z
date_updated: 2023-10-18T06:41:12Z
day: '12'
ddc:
- '570'
department:
- _id: EdHa
doi: 10.1098/rsos.181286
external_id:
  isi:
  - '000456566500027'
  pmid:
  - '30662738'
file:
- access_level: open_access
  checksum: 9664d4417f6b792242e31eea77ce9501
  content_type: application/pdf
  creator: dernst
  date_created: 2019-02-05T14:38:09Z
  date_updated: 2020-07-14T12:47:13Z
  file_id: '5924'
  file_name: 2018_RoyalSocOS_Corominas.pdf
  file_size: 646732
  relation: main_file
file_date_updated: 2020-07-14T12:47:13Z
has_accepted_license: '1'
intvolume: '         5'
isi: 1
issue: '12'
language:
- iso: eng
month: '12'
oa: 1
oa_version: Published Version
pmid: 1
publication: Royal Society Open Science
publication_identifier:
  issn:
  - 2054-5703
publication_status: published
publisher: The Royal Society
quality_controlled: '1'
scopus_import: '1'
status: public
title: Chromatic transitions in the emergence of syntax networks
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 5
year: '2018'
...
---
_id: '5860'
abstract:
- lang: eng
  text: 'A major problem for evolutionary theory is understanding the so-called open-ended
    nature of evolutionary change, from its definition to its origins. Open-ended
    evolution (OEE) refers to the unbounded increase in complexity that seems to characterize
    evolution on multiple scales. This property seems to be a characteristic feature
    of biological and technological evolution and is strongly tied to the generative
    potential associated with combinatorics, which allows the system to grow and expand
    their available state spaces. Interestingly, many complex systems presumably displaying
    OEE, from language to proteins, share a common statistical property: the presence
    of Zipf''s Law. Given an inventory of basic items (such as words or protein domains)
    required to build more complex structures (sentences or proteins) Zipf''s Law
    tells us that most of these elements are rare whereas a few of them are extremely
    common. Using algorithmic information theory, in this paper we provide a fundamental
    definition for open-endedness, which can be understood as postulates. Its statistical
    counterpart, based on standard Shannon information theory, has the structure of
    a variational problem which is shown to lead to Zipf''s Law as the expected consequence
    of an evolutionary process displaying OEE. We further explore the problem of information
    conservation through an OEE process and we conclude that statistical information
    (standard Shannon information) is not conserved, resulting in the paradoxical
    situation in which the increase of information content has the effect of erasing
    itself. We prove that this paradox is solved if we consider non-statistical forms
    of information. This last result implies that standard information theory may
    not be a suitable theoretical framework to explore the persistence and increase
    of the information content in OEE systems.'
article_number: '20180395'
article_processing_charge: No
arxiv: 1
author:
- first_name: Bernat
  full_name: Corominas-Murtra, Bernat
  id: 43BE2298-F248-11E8-B48F-1D18A9856A87
  last_name: Corominas-Murtra
  orcid: 0000-0001-9806-5643
- first_name: Luís F.
  full_name: Seoane, Luís F.
  last_name: Seoane
- first_name: Ricard
  full_name: Solé, Ricard
  last_name: Solé
citation:
  ama: Corominas-Murtra B, Seoane LF, Solé R. Zipf’s Law, unbounded complexity and
    open-ended evolution. <i>Journal of the Royal Society Interface</i>. 2018;15(149).
    doi:<a href="https://doi.org/10.1098/rsif.2018.0395">10.1098/rsif.2018.0395</a>
  apa: Corominas-Murtra, B., Seoane, L. F., &#38; Solé, R. (2018). Zipf’s Law, unbounded
    complexity and open-ended evolution. <i>Journal of the Royal Society Interface</i>.
    Royal Society Publishing. <a href="https://doi.org/10.1098/rsif.2018.0395">https://doi.org/10.1098/rsif.2018.0395</a>
  chicago: Corominas-Murtra, Bernat, Luís F. Seoane, and Ricard Solé. “Zipf’s Law,
    Unbounded Complexity and Open-Ended Evolution.” <i>Journal of the Royal Society
    Interface</i>. Royal Society Publishing, 2018. <a href="https://doi.org/10.1098/rsif.2018.0395">https://doi.org/10.1098/rsif.2018.0395</a>.
  ieee: B. Corominas-Murtra, L. F. Seoane, and R. Solé, “Zipf’s Law, unbounded complexity
    and open-ended evolution,” <i>Journal of the Royal Society Interface</i>, vol.
    15, no. 149. Royal Society Publishing, 2018.
  ista: Corominas-Murtra B, Seoane LF, Solé R. 2018. Zipf’s Law, unbounded complexity
    and open-ended evolution. Journal of the Royal Society Interface. 15(149), 20180395.
  mla: Corominas-Murtra, Bernat, et al. “Zipf’s Law, Unbounded Complexity and Open-Ended
    Evolution.” <i>Journal of the Royal Society Interface</i>, vol. 15, no. 149, 20180395,
    Royal Society Publishing, 2018, doi:<a href="https://doi.org/10.1098/rsif.2018.0395">10.1098/rsif.2018.0395</a>.
  short: B. Corominas-Murtra, L.F. Seoane, R. Solé, Journal of the Royal Society Interface
    15 (2018).
date_created: 2019-01-20T22:59:19Z
date_published: 2018-12-12T00:00:00Z
date_updated: 2023-09-19T10:40:38Z
day: '12'
department:
- _id: EdHa
doi: 10.1098/rsif.2018.0395
external_id:
  arxiv:
  - '1612.01605'
  isi:
  - '000456783800002'
intvolume: '        15'
isi: 1
issue: '149'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://arxiv.org/abs/1612.01605
month: '12'
oa: 1
oa_version: Preprint
publication: Journal of the Royal Society Interface
publication_identifier:
  issn:
  - '17425689'
publication_status: published
publisher: Royal Society Publishing
quality_controlled: '1'
scopus_import: '1'
status: public
title: Zipf's Law, unbounded complexity and open-ended evolution
type: journal_article
user_id: c635000d-4b10-11ee-a964-aac5a93f6ac1
volume: 15
year: '2018'
...
