---
_id: '7508'
abstract:
- lang: eng
text: In this paper, we introduce a novel method for deriving higher order corrections
to the mean-field description of the dynamics of interacting bosons. More precisely,
we consider the dynamics of N d-dimensional bosons for large N. The bosons initially
form a Bose–Einstein condensate and interact with each other via a pair potential
of the form (N−1)−1Ndβv(Nβ·)forβ∈[0,14d). We derive a sequence of N-body functions
which approximate the true many-body dynamics in L2(RdN)-norm to arbitrary precision
in powers of N−1. The approximating functions are constructed as Duhamel expansions
of finite order in terms of the first quantised analogue of a Bogoliubov time
evolution.
acknowledgement: "Open access funding provided by Institute of Science and Technology
(IST Austria).\r\nL.B. gratefully acknowledges the support by the German Research
Foundation (DFG) within the Research Training Group 1838 “Spectral Theory and Dynamics
of Quantum Systems”, and wishes to thank Stefan Teufel, Sören Petrat and Marcello
Porta for helpful discussions. This project has received funding from the European
Union’s Horizon 2020 research and innovation programme under the Marie Skłodowska-Curie
Grant Agreement No. 754411. N.P. gratefully acknowledges support from NSF grant
DMS-1516228 and DMS-1840314. P.P.’s research was funded by DFG Grant no. PI 1114/3-1.
Part of this work was done when N.P. and P.P. were visiting CCNU, Wuhan. N.P. and
P.P. thank A.S. for his hospitality at CCNU."
article_processing_charge: Yes (via OA deal)
article_type: original
arxiv: 1
author:
- first_name: Lea
full_name: Bossmann, Lea
id: A2E3BCBE-5FCC-11E9-AA4B-76F3E5697425
last_name: Bossmann
orcid: 0000-0002-6854-1343
- first_name: Nataša
full_name: Pavlović, Nataša
last_name: Pavlović
- first_name: Peter
full_name: Pickl, Peter
last_name: Pickl
- first_name: Avy
full_name: Soffer, Avy
last_name: Soffer
citation:
ama: Bossmann L, Pavlović N, Pickl P, Soffer A. Higher order corrections to the
mean-field description of the dynamics of interacting bosons. Journal of Statistical
Physics. 2020;178:1362-1396. doi:10.1007/s10955-020-02500-8
apa: Bossmann, L., Pavlović, N., Pickl, P., & Soffer, A. (2020). Higher order
corrections to the mean-field description of the dynamics of interacting bosons.
Journal of Statistical Physics. Springer Nature. https://doi.org/10.1007/s10955-020-02500-8
chicago: Bossmann, Lea, Nataša Pavlović, Peter Pickl, and Avy Soffer. “Higher Order
Corrections to the Mean-Field Description of the Dynamics of Interacting Bosons.”
Journal of Statistical Physics. Springer Nature, 2020. https://doi.org/10.1007/s10955-020-02500-8.
ieee: L. Bossmann, N. Pavlović, P. Pickl, and A. Soffer, “Higher order corrections
to the mean-field description of the dynamics of interacting bosons,” Journal
of Statistical Physics, vol. 178. Springer Nature, pp. 1362–1396, 2020.
ista: Bossmann L, Pavlović N, Pickl P, Soffer A. 2020. Higher order corrections
to the mean-field description of the dynamics of interacting bosons. Journal of
Statistical Physics. 178, 1362–1396.
mla: Bossmann, Lea, et al. “Higher Order Corrections to the Mean-Field Description
of the Dynamics of Interacting Bosons.” Journal of Statistical Physics,
vol. 178, Springer Nature, 2020, pp. 1362–96, doi:10.1007/s10955-020-02500-8.
short: L. Bossmann, N. Pavlović, P. Pickl, A. Soffer, Journal of Statistical Physics
178 (2020) 1362–1396.
date_created: 2020-02-23T09:45:51Z
date_published: 2020-02-21T00:00:00Z
date_updated: 2023-08-18T06:37:46Z
day: '21'
ddc:
- '510'
department:
- _id: RoSe
doi: 10.1007/s10955-020-02500-8
ec_funded: 1
external_id:
arxiv:
- '1905.06164'
isi:
- '000516342200001'
file:
- access_level: open_access
checksum: 643e230bf147e64d9cdb3f6cc573679d
content_type: application/pdf
creator: dernst
date_created: 2020-11-20T09:26:46Z
date_updated: 2020-11-20T09:26:46Z
file_id: '8780'
file_name: 2020_JournStatPhysics_Bossmann.pdf
file_size: 576726
relation: main_file
success: 1
file_date_updated: 2020-11-20T09:26:46Z
has_accepted_license: '1'
intvolume: ' 178'
isi: 1
language:
- iso: eng
month: '02'
oa: 1
oa_version: Published Version
page: 1362-1396
project:
- _id: B67AFEDC-15C9-11EA-A837-991A96BB2854
name: IST Austria Open Access Fund
- _id: 260C2330-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '754411'
name: ISTplus - Postdoctoral Fellowships
publication: Journal of Statistical Physics
publication_identifier:
eissn:
- 1572-9613
issn:
- 0022-4715
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
scopus_import: '1'
status: public
title: Higher order corrections to the mean-field description of the dynamics of interacting
bosons
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 178
year: '2020'
...
---
_id: '7509'
abstract:
- lang: eng
text: "In this paper we study the joint convexity/concavity of the trace functions
Ψp,q,s(A,B)=Tr(Bq2K∗ApKBq2)s, p,q,s∈R,\r\nwhere A and B are positive definite
matrices and K is any fixed invertible matrix. We will give full range of (p,q,s)∈R3
for Ψp,q,s to be jointly convex/concave for all K. As a consequence, we confirm
a conjecture of Carlen, Frank and Lieb. In particular, we confirm a weaker conjecture
of Audenaert and Datta and obtain the full range of (α,z) for α-z Rényi relative
entropies to be monotone under completely positive trace preserving maps. We also
give simpler proofs of many known results, including the concavity of Ψp,0,1/p
for 0Advances in Mathematics. 2020;365. doi:10.1016/j.aim.2020.107053
apa: Zhang, H. (2020). From Wigner-Yanase-Dyson conjecture to Carlen-Frank-Lieb
conjecture. Advances in Mathematics. Elsevier. https://doi.org/10.1016/j.aim.2020.107053
chicago: Zhang, Haonan. “From Wigner-Yanase-Dyson Conjecture to Carlen-Frank-Lieb
Conjecture.” Advances in Mathematics. Elsevier, 2020. https://doi.org/10.1016/j.aim.2020.107053.
ieee: H. Zhang, “From Wigner-Yanase-Dyson conjecture to Carlen-Frank-Lieb conjecture,”
Advances in Mathematics, vol. 365. Elsevier, 2020.
ista: Zhang H. 2020. From Wigner-Yanase-Dyson conjecture to Carlen-Frank-Lieb conjecture.
Advances in Mathematics. 365, 107053.
mla: Zhang, Haonan. “From Wigner-Yanase-Dyson Conjecture to Carlen-Frank-Lieb Conjecture.”
Advances in Mathematics, vol. 365, 107053, Elsevier, 2020, doi:10.1016/j.aim.2020.107053.
short: H. Zhang, Advances in Mathematics 365 (2020).
date_created: 2020-02-23T21:43:50Z
date_published: 2020-05-13T00:00:00Z
date_updated: 2023-08-18T06:37:09Z
day: '13'
ddc:
- '515'
department:
- _id: JaMa
doi: 10.1016/j.aim.2020.107053
ec_funded: 1
external_id:
arxiv:
- '1811.01205'
isi:
- '000522798000001'
intvolume: ' 365'
isi: 1
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://arxiv.org/abs/1811.01205
month: '05'
oa: 1
oa_version: Preprint
project:
- _id: 260C2330-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '754411'
name: ISTplus - Postdoctoral Fellowships
publication: Advances in Mathematics
publication_status: published
publisher: Elsevier
quality_controlled: '1'
status: public
title: From Wigner-Yanase-Dyson conjecture to Carlen-Frank-Lieb conjecture
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 365
year: '2020'
...
---
_id: '7511'
abstract:
- lang: eng
text: Cryo electron tomography with subsequent subtomogram averaging is a powerful
technique to structurally analyze macromolecular complexes in their native context.
Although close to atomic resolution in principle can be obtained, it is not clear
how individual experimental parameters contribute to the attainable resolution.
Here, we have used immature HIV-1 lattice as a benchmarking sample to optimize
the attainable resolution for subtomogram averaging. We systematically tested
various experimental parameters such as the order of projections, different angular
increments and the use of the Volta phase plate. We find that although any of
the prominently used acquisition schemes is sufficient to obtain subnanometer
resolution, dose-symmetric acquisition provides considerably better outcome. We
discuss our findings in order to provide guidance for data acquisition. Our data
is publicly available and might be used to further develop processing routines.
article_number: '876'
article_processing_charge: No
article_type: original
author:
- first_name: Beata
full_name: Turoňová, Beata
last_name: Turoňová
- first_name: Wim J.H.
full_name: Hagen, Wim J.H.
last_name: Hagen
- first_name: Martin
full_name: Obr, Martin
id: 4741CA5A-F248-11E8-B48F-1D18A9856A87
last_name: Obr
orcid: 0000-0003-1756-6564
- first_name: Shyamal
full_name: Mosalaganti, Shyamal
last_name: Mosalaganti
- first_name: J. Wouter
full_name: Beugelink, J. Wouter
last_name: Beugelink
- first_name: Christian E.
full_name: Zimmerli, Christian E.
last_name: Zimmerli
- first_name: Hans Georg
full_name: Kräusslich, Hans Georg
last_name: Kräusslich
- first_name: Martin
full_name: Beck, Martin
last_name: Beck
citation:
ama: Turoňová B, Hagen WJH, Obr M, et al. Benchmarking tomographic acquisition schemes
for high-resolution structural biology. Nature Communications. 2020;11.
doi:10.1038/s41467-020-14535-2
apa: Turoňová, B., Hagen, W. J. H., Obr, M., Mosalaganti, S., Beugelink, J. W.,
Zimmerli, C. E., … Beck, M. (2020). Benchmarking tomographic acquisition schemes
for high-resolution structural biology. Nature Communications. Springer
Nature. https://doi.org/10.1038/s41467-020-14535-2
chicago: Turoňová, Beata, Wim J.H. Hagen, Martin Obr, Shyamal Mosalaganti, J. Wouter
Beugelink, Christian E. Zimmerli, Hans Georg Kräusslich, and Martin Beck. “Benchmarking
Tomographic Acquisition Schemes for High-Resolution Structural Biology.” Nature
Communications. Springer Nature, 2020. https://doi.org/10.1038/s41467-020-14535-2.
ieee: B. Turoňová et al., “Benchmarking tomographic acquisition schemes for
high-resolution structural biology,” Nature Communications, vol. 11. Springer
Nature, 2020.
ista: Turoňová B, Hagen WJH, Obr M, Mosalaganti S, Beugelink JW, Zimmerli CE, Kräusslich
HG, Beck M. 2020. Benchmarking tomographic acquisition schemes for high-resolution
structural biology. Nature Communications. 11, 876.
mla: Turoňová, Beata, et al. “Benchmarking Tomographic Acquisition Schemes for High-Resolution
Structural Biology.” Nature Communications, vol. 11, 876, Springer Nature,
2020, doi:10.1038/s41467-020-14535-2.
short: B. Turoňová, W.J.H. Hagen, M. Obr, S. Mosalaganti, J.W. Beugelink, C.E. Zimmerli,
H.G. Kräusslich, M. Beck, Nature Communications 11 (2020).
date_created: 2020-02-23T23:00:35Z
date_published: 2020-02-13T00:00:00Z
date_updated: 2023-08-18T06:36:41Z
day: '13'
ddc:
- '570'
department:
- _id: FlSc
doi: 10.1038/s41467-020-14535-2
external_id:
isi:
- '000514928000017'
file:
- access_level: open_access
checksum: 2c8d10475e1b0d397500760e28bdf561
content_type: application/pdf
creator: dernst
date_created: 2020-02-24T14:00:54Z
date_updated: 2020-07-14T12:47:59Z
file_id: '7517'
file_name: 2020_NatureComm_Turonova.pdf
file_size: 2027529
relation: main_file
file_date_updated: 2020-07-14T12:47:59Z
has_accepted_license: '1'
intvolume: ' 11'
isi: 1
language:
- iso: eng
month: '02'
oa: 1
oa_version: Published Version
publication: Nature Communications
publication_identifier:
eissn:
- '20411723'
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
scopus_import: '1'
status: public
title: Benchmarking tomographic acquisition schemes for high-resolution structural
biology
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 11
year: '2020'
...
---
_id: '7512'
abstract:
- lang: eng
text: We consider general self-adjoint polynomials in several independent random
matrices whose entries are centered and have the same variance. We show that under
certain conditions the local law holds up to the optimal scale, i.e., the eigenvalue
density on scales just above the eigenvalue spacing follows the global density
of states which is determined by free probability theory. We prove that these
conditions hold for general homogeneous polynomials of degree two and for symmetrized
products of independent matrices with i.i.d. entries, thus establishing the optimal
bulk local law for these classes of ensembles. In particular, we generalize a
similar result of Anderson for anticommutator. For more general polynomials our
conditions are effectively checkable numerically.
acknowledgement: "The authors are grateful to Oskari Ajanki for his invaluable help
at the initial stage of this project, to Serban Belinschi for useful discussions,
to Alexander Tikhomirov for calling our attention to the model example in Section
6.2 and to the anonymous referee for suggesting to simplify certain proofs. Erdös:
Partially funded by ERC Advanced Grant RANMAT No. 338804\r\n"
article_number: '108507'
article_processing_charge: No
article_type: original
arxiv: 1
author:
- first_name: László
full_name: Erdös, László
id: 4DBD5372-F248-11E8-B48F-1D18A9856A87
last_name: Erdös
orcid: 0000-0001-5366-9603
- first_name: Torben H
full_name: Krüger, Torben H
id: 3020C786-F248-11E8-B48F-1D18A9856A87
last_name: Krüger
orcid: 0000-0002-4821-3297
- first_name: Yuriy
full_name: Nemish, Yuriy
id: 4D902E6A-F248-11E8-B48F-1D18A9856A87
last_name: Nemish
orcid: 0000-0002-7327-856X
citation:
ama: Erdös L, Krüger TH, Nemish Y. Local laws for polynomials of Wigner matrices.
Journal of Functional Analysis. 2020;278(12). doi:10.1016/j.jfa.2020.108507
apa: Erdös, L., Krüger, T. H., & Nemish, Y. (2020). Local laws for polynomials
of Wigner matrices. Journal of Functional Analysis. Elsevier. https://doi.org/10.1016/j.jfa.2020.108507
chicago: Erdös, László, Torben H Krüger, and Yuriy Nemish. “Local Laws for Polynomials
of Wigner Matrices.” Journal of Functional Analysis. Elsevier, 2020. https://doi.org/10.1016/j.jfa.2020.108507.
ieee: L. Erdös, T. H. Krüger, and Y. Nemish, “Local laws for polynomials of Wigner
matrices,” Journal of Functional Analysis, vol. 278, no. 12. Elsevier,
2020.
ista: Erdös L, Krüger TH, Nemish Y. 2020. Local laws for polynomials of Wigner matrices.
Journal of Functional Analysis. 278(12), 108507.
mla: Erdös, László, et al. “Local Laws for Polynomials of Wigner Matrices.” Journal
of Functional Analysis, vol. 278, no. 12, 108507, Elsevier, 2020, doi:10.1016/j.jfa.2020.108507.
short: L. Erdös, T.H. Krüger, Y. Nemish, Journal of Functional Analysis 278 (2020).
date_created: 2020-02-23T23:00:36Z
date_published: 2020-07-01T00:00:00Z
date_updated: 2023-08-18T06:36:10Z
day: '01'
department:
- _id: LaEr
doi: 10.1016/j.jfa.2020.108507
ec_funded: 1
external_id:
arxiv:
- '1804.11340'
isi:
- '000522798900001'
intvolume: ' 278'
isi: 1
issue: '12'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://arxiv.org/abs/1804.11340
month: '07'
oa: 1
oa_version: Preprint
project:
- _id: 258DCDE6-B435-11E9-9278-68D0E5697425
call_identifier: FP7
grant_number: '338804'
name: Random matrices, universality and disordered quantum systems
publication: Journal of Functional Analysis
publication_identifier:
eissn:
- '10960783'
issn:
- '00221236'
publication_status: published
publisher: Elsevier
quality_controlled: '1'
scopus_import: '1'
status: public
title: Local laws for polynomials of Wigner matrices
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 278
year: '2020'
...
---
_id: '7514'
abstract:
- lang: eng
text: "We study the interacting homogeneous Bose gas in two spatial dimensions in
the thermodynamic limit at fixed density. We shall be concerned with some mathematical
aspects of this complicated problem in many-body quantum mechanics. More specifically,
we consider the dilute limit where the scattering length of the interaction potential,
which is a measure for the effective range of the potential, is small compared
to the average distance between the particles. We are interested in a setting
with positive (i.e., non-zero) temperature. After giving a survey of the relevant
literature in the field, we provide some facts and examples to set expectations
for the two-dimensional system. The crucial difference to the three-dimensional
system is that there is no Bose–Einstein condensate at positive temperature due
to the Hohenberg–Mermin–Wagner theorem. However, it turns out that an asymptotic
formula for the free energy holds similarly to the three-dimensional case.\r\nWe
motivate this formula by considering a toy model with δ interaction potential.
By restricting this model Hamiltonian to certain trial states with a quasi-condensate
we obtain an upper bound for the free energy that still has the quasi-condensate
fraction as a free parameter. When minimizing over the quasi-condensate fraction,
we obtain the Berezinskii–Kosterlitz–Thouless critical temperature for superfluidity,
which plays an important role in our rigorous contribution. The mathematically
rigorous result that we prove concerns the specific free energy in the dilute
limit. We give upper and lower bounds on the free energy in terms of the free
energy of the non-interacting system and a correction term coming from the interaction.
Both bounds match and thus we obtain the leading term of an asymptotic approximation
in the dilute limit, provided the thermal wavelength of the particles is of the
same order (or larger) than the average distance between the particles. The remarkable
feature of this result is its generality: the correction term depends on the interaction
potential only through its scattering length and it holds for all nonnegative
interaction potentials with finite scattering length that are measurable. In particular,
this allows to model an interaction of hard disks."
alternative_title:
- ISTA Thesis
article_processing_charge: No
author:
- first_name: Simon
full_name: Mayer, Simon
id: 30C4630A-F248-11E8-B48F-1D18A9856A87
last_name: Mayer
citation:
ama: Mayer S. The free energy of a dilute two-dimensional Bose gas. 2020. doi:10.15479/AT:ISTA:7514
apa: Mayer, S. (2020). The free energy of a dilute two-dimensional Bose gas.
Institute of Science and Technology Austria. https://doi.org/10.15479/AT:ISTA:7514
chicago: Mayer, Simon. “The Free Energy of a Dilute Two-Dimensional Bose Gas.” Institute
of Science and Technology Austria, 2020. https://doi.org/10.15479/AT:ISTA:7514.
ieee: S. Mayer, “The free energy of a dilute two-dimensional Bose gas,” Institute
of Science and Technology Austria, 2020.
ista: Mayer S. 2020. The free energy of a dilute two-dimensional Bose gas. Institute
of Science and Technology Austria.
mla: Mayer, Simon. The Free Energy of a Dilute Two-Dimensional Bose Gas.
Institute of Science and Technology Austria, 2020, doi:10.15479/AT:ISTA:7514.
short: S. Mayer, The Free Energy of a Dilute Two-Dimensional Bose Gas, Institute
of Science and Technology Austria, 2020.
date_created: 2020-02-24T09:17:27Z
date_published: 2020-02-24T00:00:00Z
date_updated: 2023-09-07T13:12:42Z
day: '24'
ddc:
- '510'
degree_awarded: PhD
department:
- _id: RoSe
- _id: GradSch
doi: 10.15479/AT:ISTA:7514
ec_funded: 1
file:
- access_level: open_access
checksum: b4de7579ddc1dbdd44ff3f17c48395f6
content_type: application/pdf
creator: dernst
date_created: 2020-02-24T09:15:06Z
date_updated: 2020-07-14T12:47:59Z
file_id: '7515'
file_name: thesis.pdf
file_size: 1563429
relation: main_file
- access_level: closed
checksum: ad7425867b52d7d9e72296e87bc9cb67
content_type: application/x-zip-compressed
creator: dernst
date_created: 2020-02-24T09:15:16Z
date_updated: 2020-07-14T12:47:59Z
file_id: '7516'
file_name: thesis_source.zip
file_size: 2028038
relation: source_file
file_date_updated: 2020-07-14T12:47:59Z
has_accepted_license: '1'
language:
- iso: eng
month: '02'
oa: 1
oa_version: Published Version
page: '148'
project:
- _id: 25C6DC12-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '694227'
name: Analysis of quantum many-body systems
publication_identifier:
issn:
- 2663-337X
publication_status: published
publisher: Institute of Science and Technology Austria
related_material:
record:
- id: '7524'
relation: part_of_dissertation
status: public
status: public
supervisor:
- first_name: Robert
full_name: Seiringer, Robert
id: 4AFD0470-F248-11E8-B48F-1D18A9856A87
last_name: Seiringer
orcid: 0000-0002-6781-0521
title: The free energy of a dilute two-dimensional Bose gas
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: dissertation
user_id: c635000d-4b10-11ee-a964-aac5a93f6ac1
year: '2020'
...
---
_id: '7525'
abstract:
- lang: eng
text: "The medial habenula (MHb) is an evolutionary conserved epithalamic structure
important for the modulation of emotional memory. It is involved in regulation
of anxiety, compulsive behavior, addiction (nicotinic and opioid), sexual and
feeding behavior. MHb receives inputs from septal regions and projects exclusively
to the interpeduncular nucleus (IPN). Distinct sub-regions of the septum project
to different subnuclei of MHb: the bed nucleus of anterior commissure projects
to dorsal MHb and the triangular septum projects to ventral MHb. Furthermore,
the dorsal and ventral MHb project to the lateral and rostral/central IPN, respectively.
Importantly, these projections have unique features of prominent co-release of
different neurotransmitters and requirement of a peculiar type of calcium channel
for release. In general, synaptic neurotransmission requires an activity-dependent
influx of Ca2+ into the presynaptic terminal through voltage-gated calcium channels.
The calcium channel family most commonly involved in neurotransmitter release
comprises three members, P/Q-, N- and R-type with Cav2.1, Cav2.2 and Cav2.3 subunits,
respectively. In contrast to most CNS synapses that mainly express Cav2.1 and/or
Cav2.2, MHb terminals in the IPN exclusively express Cav2.3. In other parts of
the brain, such as the hippocampus, Cav2.3 is mostly located to postsynaptic elements.
This unusual presynaptic location of Cav2.3 in the MHb-IPN pathway implies unique
mechanisms of glutamate release in this pathway. One potential example of such
uniqueness is the facilitation of release by GABAB receptor (GBR) activation.
Presynaptic GBRs usually inhibit the release of neurotransmitters by inhibiting
presynaptic calcium channels. MHb shows the highest expression levels of GBR in
the brain. GBRs comprise two subunits, GABAB1 (GB1) and GABAB2 (GB2), and are
associated with auxiliary subunits, called potassium channel tetramerization domain
containing proteins (KCTD) 8, 12, 12b and 16. Among these four subunits, KCTD12b
is exclusively expressed in ventral MHb, and KCTD8 shows the strongest expression
in the whole MHb among other brain regions, indicating that KCTD8 and KCTD12b
may be involved in the unique mechanisms of neurotransmitter release mediated
by Cav2.3 and regulated by GBRs in this pathway. \r\nIn the present study, we
first verified that neurotransmission in both dorsal and ventral MHb-IPN pathways
is mainly mediated by Cav2.3 using a selective blocker of R-type channels, SNX-482.
We next found that baclofen, a GBR agonist, has facilitatory effects on release
from ventral MHb terminal in rostral IPN, whereas it has inhibitory effects on
release from dorsal MHb terminals in lateral IPN, indicating that KCTD12b expressed
exclusively in ventral MHb may have a role in the facilitatory effects of GBR
activation. In a heterologous expression system using HEK cells, we found that
KCTD8 and KCTD12b but not KCTD12 directly bind with Cav2.3. Pre-embedding immunogold
electron microscopy data show that Cav2.3 and KCTD12b are distributed most densely
in presynaptic active zone in IPN with KCTD12b being present only in rostral/central
but not lateral IPN, whereas GABAB, KCTD8 and KCTD12 are distributed most densely
in perisynaptic sites with KCTD12 present more frequently in postsynaptic elements
and only in rostral/central IPN. In freeze-fracture replica labelling, Cav2.3,
KCTD8 and KCTD12b are co-localized with each other in the same active zone indicating
that they may form complexes regulating vesicle release in rostral IPN. \r\nOn
electrophysiological studies of wild type (WT) mice, we found that paired-pulse
ratio in rostral IPN of KCTD12b knock-out (KO) mice is lower than those of WT
and KCTD8 KO mice. Consistent with this finding, in mean variance analysis, release
probability in rostral IPN of KCTD12b KO mice is higher than that of WT and KCTD8
KO mice. Although paired-pulse ratios are not different between WT and KCTD8 KO
mice, the mean variance analysis revealed significantly lower release probability
in rostral IPN of KCTD8 KO than WT mice. These results demonstrate bidirectional
regulation of Cav2.3-mediated release by KCTD8 and KCTD12b without GBR activation
in rostral IPN. Finally, we examined the baclofen effects in rostral IPN of KCTD8
and KCTD12b KO mice, and found the facilitation of release remained in both KO
mice, indicating that the peculiar effects of the GBR activation in this pathway
do not depend on the selective expression of these KCTD subunits in ventral MHb.
However, we found that presynaptic potentiation of evoked EPSC amplitude by baclofen
falls to baseline after washout faster in KCTD12b KO mice than WT, KCTD8 KO and
KCTD8/12b double KO mice. This result indicates that KCTD12b is involved in sustained
potentiation of vesicle release by GBR activation, whereas KCTD8 is involved in
its termination in the absence of KCTD12b. Consistent with these functional findings,
replica labelling revealed an increase in density of KCTD8, but not Cav2.3 or
GBR at active zone in rostral IPN of KCTD12b KO mice compared with that of WT
mice, suggesting that increased association of KCTD8 with Cav2.3 facilitates the
release probability and termination of the GBR effect in the absence of KCTD12b.\r\nIn
summary, our study provided new insights into the physiological roles of presynaptic
Cav2.3, GBRs and their auxiliary subunits KCTDs at an evolutionary conserved neuronal
circuit. Future studies will be required to identify the exact molecular mechanism
underlying the GBR-mediated presynaptic potentiation on ventral MHb terminals.
It remains to be determined whether the prominent presence of presynaptic KCTDs
at active zone could exert similar neuromodulatory functions in different pathways
of the brain.\r\n"
acknowledged_ssus:
- _id: EM-Fac
alternative_title:
- ISTA Thesis
article_processing_charge: No
author:
- first_name: Pradeep
full_name: Bhandari, Pradeep
id: 45EDD1BC-F248-11E8-B48F-1D18A9856A87
last_name: Bhandari
orcid: 0000-0003-0863-4481
citation:
ama: Bhandari P. Localization and functional role of Cav2.3 in the medial habenula
to interpeduncular nucleus pathway. 2020. doi:10.15479/AT:ISTA:7525
apa: Bhandari, P. (2020). Localization and functional role of Cav2.3 in the medial
habenula to interpeduncular nucleus pathway. Institute of Science and Technology
Austria. https://doi.org/10.15479/AT:ISTA:7525
chicago: Bhandari, Pradeep. “Localization and Functional Role of Cav2.3 in the Medial
Habenula to Interpeduncular Nucleus Pathway.” Institute of Science and Technology
Austria, 2020. https://doi.org/10.15479/AT:ISTA:7525.
ieee: P. Bhandari, “Localization and functional role of Cav2.3 in the medial habenula
to interpeduncular nucleus pathway,” Institute of Science and Technology Austria,
2020.
ista: Bhandari P. 2020. Localization and functional role of Cav2.3 in the medial
habenula to interpeduncular nucleus pathway. Institute of Science and Technology
Austria.
mla: Bhandari, Pradeep. Localization and Functional Role of Cav2.3 in the Medial
Habenula to Interpeduncular Nucleus Pathway. Institute of Science and Technology
Austria, 2020, doi:10.15479/AT:ISTA:7525.
short: P. Bhandari, Localization and Functional Role of Cav2.3 in the Medial Habenula
to Interpeduncular Nucleus Pathway, Institute of Science and Technology Austria,
2020.
date_created: 2020-02-26T10:56:37Z
date_published: 2020-02-28T00:00:00Z
date_updated: 2023-09-07T13:20:03Z
day: '28'
ddc:
- '570'
degree_awarded: PhD
department:
- _id: RySh
doi: 10.15479/AT:ISTA:7525
file:
- access_level: open_access
checksum: 4589234fdb12b4ad72273b311723a7b4
content_type: application/pdf
creator: pbhandari
date_created: 2020-02-28T08:37:53Z
date_updated: 2021-03-01T23:30:04Z
embargo: 2021-02-28
file_id: '7538'
file_name: Pradeep Bhandari Thesis.pdf
file_size: 9646346
relation: main_file
title: Localization and functional role of Cav2.3 in the medial habenula to interpeduncular
nucleus pathway
- access_level: closed
checksum: aa79490553ca0a5c9b6fbcd152e93928
content_type: application/vnd.openxmlformats-officedocument.wordprocessingml.document
creator: pbhandari
date_created: 2020-02-28T08:47:14Z
date_updated: 2021-03-01T23:30:04Z
embargo_to: open_access
file_id: '7539'
file_name: Pradeep Bhandari Thesis.docx
file_size: 35252164
relation: source_file
title: Localization and functional role of Cav2.3 in the medial habenula to interpeduncular
nucleus pathway
file_date_updated: 2021-03-01T23:30:04Z
has_accepted_license: '1'
keyword:
- Cav2.3
- medial habenula (MHb)
- interpeduncular nucleus (IPN)
language:
- iso: eng
month: '02'
oa: 1
oa_version: Published Version
page: '79'
publication_identifier:
issn:
- 2663-337X
publication_status: published
publisher: Institute of Science and Technology Austria
status: public
supervisor:
- first_name: Ryuichi
full_name: Shigemoto, Ryuichi
id: 499F3ABC-F248-11E8-B48F-1D18A9856A87
last_name: Shigemoto
orcid: 0000-0001-8761-9444
title: Localization and functional role of Cav2.3 in the medial habenula to interpeduncular
nucleus pathway
type: dissertation
user_id: c635000d-4b10-11ee-a964-aac5a93f6ac1
year: '2020'
...
---
_id: '7534'
abstract:
- lang: eng
text: 'In the past two decades, our understanding of the transition to turbulence
in shear flows with linearly stable laminar solutions has greatly improved. Regarding
the susceptibility of the laminar flow, two concepts have been particularly useful:
the edge states and the minimal seeds. In this nonlinear picture of the transition,
the basin boundary of turbulence is set by the edge state''s stable manifold and
this manifold comes closest in energy to the laminar equilibrium at the minimal
seed. We begin this paper by presenting numerical experiments in which three-dimensional
perturbations are too energetic to trigger turbulence in pipe flow but they do
lead to turbulence when their amplitude is reduced. We show that this seemingly
counterintuitive observation is in fact consistent with the fully nonlinear description
of the transition mediated by the edge state. In order to understand the physical
mechanisms behind this process, we measure the turbulent kinetic energy production
and dissipation rates as a function of the radial coordinate. Our main observation
is that the transition to turbulence relies on the energy amplification away from
the wall, as opposed to the turbulence itself, whose energy is predominantly produced
near the wall. This observation is further supported by the similar analyses on
the minimal seeds and the edge states. Furthermore, we show that the time evolution
of production-over-dissipation curves provides a clear distinction between the
different initial amplification stages of the transition to turbulence from the
minimal seed.'
article_number: '023903'
article_processing_charge: No
article_type: original
arxiv: 1
author:
- first_name: Nazmi B
full_name: Budanur, Nazmi B
id: 3EA1010E-F248-11E8-B48F-1D18A9856A87
last_name: Budanur
orcid: 0000-0003-0423-5010
- first_name: Elena
full_name: Marensi, Elena
last_name: Marensi
- first_name: Ashley P.
full_name: Willis, Ashley P.
last_name: Willis
- first_name: Björn
full_name: Hof, Björn
id: 3A374330-F248-11E8-B48F-1D18A9856A87
last_name: Hof
orcid: 0000-0003-2057-2754
citation:
ama: Budanur NB, Marensi E, Willis AP, Hof B. Upper edge of chaos and the energetics
of transition in pipe flow. Physical Review Fluids. 2020;5(2). doi:10.1103/physrevfluids.5.023903
apa: Budanur, N. B., Marensi, E., Willis, A. P., & Hof, B. (2020). Upper edge
of chaos and the energetics of transition in pipe flow. Physical Review Fluids.
American Physical Society. https://doi.org/10.1103/physrevfluids.5.023903
chicago: Budanur, Nazmi B, Elena Marensi, Ashley P. Willis, and Björn Hof. “Upper
Edge of Chaos and the Energetics of Transition in Pipe Flow.” Physical Review
Fluids. American Physical Society, 2020. https://doi.org/10.1103/physrevfluids.5.023903.
ieee: N. B. Budanur, E. Marensi, A. P. Willis, and B. Hof, “Upper edge of chaos
and the energetics of transition in pipe flow,” Physical Review Fluids,
vol. 5, no. 2. American Physical Society, 2020.
ista: Budanur NB, Marensi E, Willis AP, Hof B. 2020. Upper edge of chaos and the
energetics of transition in pipe flow. Physical Review Fluids. 5(2), 023903.
mla: Budanur, Nazmi B., et al. “Upper Edge of Chaos and the Energetics of Transition
in Pipe Flow.” Physical Review Fluids, vol. 5, no. 2, 023903, American
Physical Society, 2020, doi:10.1103/physrevfluids.5.023903.
short: N.B. Budanur, E. Marensi, A.P. Willis, B. Hof, Physical Review Fluids 5 (2020).
date_created: 2020-02-27T10:26:57Z
date_published: 2020-02-21T00:00:00Z
date_updated: 2023-08-18T06:44:46Z
day: '21'
department:
- _id: BjHo
doi: 10.1103/physrevfluids.5.023903
external_id:
arxiv:
- '1912.09270'
isi:
- '000515065100001'
intvolume: ' 5'
isi: 1
issue: '2'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://arxiv.org/abs/1912.09270
month: '02'
oa: 1
oa_version: Preprint
publication: Physical Review Fluids
publication_identifier:
issn:
- 2469-990X
publication_status: published
publisher: American Physical Society
quality_controlled: '1'
scopus_import: '1'
status: public
title: Upper edge of chaos and the energetics of transition in pipe flow
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 5
year: '2020'
...
---
_id: '7540'
abstract:
- lang: eng
text: ' In vitro propagation of the ornamentally interesting species Wikstroemia
gemmata is limited by the recalcitrance to form adventitious roots. In this article,
two strategies to improve the rooting capacity of in vitro microcuttings are presented.
Firstly, the effect of exogenous auxin was evaluated in both light and dark cultivated
stem segments and also the sucrose-content of the medium was varied in order to
determine better rooting conditions. Secondly, different spectral lights were
evaluated and the effect on shoot growth and root induction demonstrated that
the exact spectral composition of light is important for successful in vitro growth
and development of Wikstroemia gemmata. We show that exogenous auxin cannot compensate
for the poor rooting under unfavorable light conditions. Adapting the culture
conditions is therefore paramount for successful industrial propagation of Wikstroemia
gemmata. '
article_processing_charge: No
article_type: original
author:
- first_name: Inge
full_name: Verstraeten, Inge
id: 362BF7FE-F248-11E8-B48F-1D18A9856A87
last_name: Verstraeten
orcid: 0000-0001-7241-2328
- first_name: H.
full_name: Buyle, H.
last_name: Buyle
- first_name: S.
full_name: Werbrouck, S.
last_name: Werbrouck
- first_name: M.C.
full_name: Van Labeke, M.C.
last_name: Van Labeke
- first_name: D.
full_name: Geelen, D.
last_name: Geelen
citation:
ama: Verstraeten I, Buyle H, Werbrouck S, Van Labeke MC, Geelen D. In vitro shoot
growth and adventitious rooting of Wikstroemia gemmata depends on light quality.
Israel Journal of Plant Sciences. 2020;67(1-2):16-26. doi:10.1163/22238980-20191110
apa: Verstraeten, I., Buyle, H., Werbrouck, S., Van Labeke, M. C., & Geelen,
D. (2020). In vitro shoot growth and adventitious rooting of Wikstroemia gemmata
depends on light quality. Israel Journal of Plant Sciences. Brill. https://doi.org/10.1163/22238980-20191110
chicago: Verstraeten, Inge, H. Buyle, S. Werbrouck, M.C. Van Labeke, and D. Geelen.
“In Vitro Shoot Growth and Adventitious Rooting of Wikstroemia Gemmata Depends
on Light Quality.” Israel Journal of Plant Sciences. Brill, 2020. https://doi.org/10.1163/22238980-20191110.
ieee: I. Verstraeten, H. Buyle, S. Werbrouck, M. C. Van Labeke, and D. Geelen, “In
vitro shoot growth and adventitious rooting of Wikstroemia gemmata depends on
light quality,” Israel Journal of Plant Sciences, vol. 67, no. 1–2. Brill,
pp. 16–26, 2020.
ista: Verstraeten I, Buyle H, Werbrouck S, Van Labeke MC, Geelen D. 2020. In vitro
shoot growth and adventitious rooting of Wikstroemia gemmata depends on light
quality. Israel Journal of Plant Sciences. 67(1–2), 16–26.
mla: Verstraeten, Inge, et al. “In Vitro Shoot Growth and Adventitious Rooting of
Wikstroemia Gemmata Depends on Light Quality.” Israel Journal of Plant Sciences,
vol. 67, no. 1–2, Brill, 2020, pp. 16–26, doi:10.1163/22238980-20191110.
short: I. Verstraeten, H. Buyle, S. Werbrouck, M.C. Van Labeke, D. Geelen, Israel
Journal of Plant Sciences 67 (2020) 16–26.
date_created: 2020-02-28T09:18:01Z
date_published: 2020-02-01T00:00:00Z
date_updated: 2023-08-18T06:45:15Z
day: '01'
department:
- _id: JiFr
doi: 10.1163/22238980-20191110
external_id:
isi:
- '000525343300004'
intvolume: ' 67'
isi: 1
issue: 1-2
language:
- iso: eng
month: '02'
oa_version: None
page: 16-26
publication: Israel Journal of Plant Sciences
publication_identifier:
eissn:
- 2223-8980
issn:
- 0792-9978
publication_status: published
publisher: Brill
quality_controlled: '1'
scopus_import: '1'
status: public
title: In vitro shoot growth and adventitious rooting of Wikstroemia gemmata depends
on light quality
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 67
year: '2020'
...
---
_id: '7541'
abstract:
- lang: eng
text: Semiconductor nanowires have been playing a crucial role in the development
of nanoscale devices for the realization of spin qubits, Majorana fermions, single
photon emitters, nanoprocessors, etc. The monolithic growth of site‐controlled
nanowires is a prerequisite toward the next generation of devices that will require
addressability and scalability. Here, combining top‐down nanofabrication and bottom‐up
self‐assembly, the growth of Ge wires on prepatterned Si (001) substrates with
controllable position, distance, length, and structure is reported. This is achieved
by a novel growth process that uses a SiGe strain‐relaxation template and can
be potentially generalized to other material combinations. Transport measurements
show an electrically tunable spin–orbit coupling, with a spin–orbit length similar
to that of III–V materials. Also, charge sensing between quantum dots in closely
spaced wires is observed, which underlines their potential for the realization
of advanced quantum devices. The reported results open a path toward scalable
qubit devices using nanowires on silicon.
acknowledged_ssus:
- _id: NanoFab
- _id: M-Shop
acknowledgement: 'This work was supported by the National Key R&D Program of China
(Grant Nos. 2016YFA0301701 and 2016YFA0300600), the NSFC (Grant Nos. 11574356, 11434010,
and 11404252), the Strategic Priority Research Program of CAS (Grant No. XDB30000000),
the ERC Starting Grant No. 335497, the FWF P32235 project, and the European Union''s
Horizon 2020 research and innovation program under Grant Agreement #862046. This
research was supported by the Scientific Service Units of IST Austria through resources
provided by the MIBA Machine Shop and the nanofabrication facility. F.L. thanks
support from DOE (Grant No. DE‐FG02‐04ER46148). H.H. thanks the Startup Funding
from Xi''an Jiaotong University.'
article_number: '1906523'
article_processing_charge: Yes (via OA deal)
article_type: original
author:
- first_name: Fei
full_name: Gao, Fei
last_name: Gao
- first_name: Jian-Huan
full_name: Wang, Jian-Huan
last_name: Wang
- first_name: Hannes
full_name: Watzinger, Hannes
id: 35DF8E50-F248-11E8-B48F-1D18A9856A87
last_name: Watzinger
- first_name: Hao
full_name: Hu, Hao
last_name: Hu
- first_name: Marko J.
full_name: Rančić, Marko J.
last_name: Rančić
- first_name: Jie-Yin
full_name: Zhang, Jie-Yin
last_name: Zhang
- first_name: Ting
full_name: Wang, Ting
last_name: Wang
- first_name: Yuan
full_name: Yao, Yuan
last_name: Yao
- first_name: Gui-Lei
full_name: Wang, Gui-Lei
last_name: Wang
- first_name: Josip
full_name: Kukucka, Josip
id: 3F5D8856-F248-11E8-B48F-1D18A9856A87
last_name: Kukucka
- first_name: Lada
full_name: Vukušić, Lada
id: 31E9F056-F248-11E8-B48F-1D18A9856A87
last_name: Vukušić
orcid: 0000-0003-2424-8636
- first_name: Christoph
full_name: Kloeffel, Christoph
last_name: Kloeffel
- first_name: Daniel
full_name: Loss, Daniel
last_name: Loss
- first_name: Feng
full_name: Liu, Feng
last_name: Liu
- first_name: Georgios
full_name: Katsaros, Georgios
id: 38DB5788-F248-11E8-B48F-1D18A9856A87
last_name: Katsaros
orcid: 0000-0001-8342-202X
- first_name: Jian-Jun
full_name: Zhang, Jian-Jun
last_name: Zhang
citation:
ama: Gao F, Wang J-H, Watzinger H, et al. Site-controlled uniform Ge/Si hut wires
with electrically tunable spin-orbit coupling. Advanced Materials. 2020;32(16).
doi:10.1002/adma.201906523
apa: Gao, F., Wang, J.-H., Watzinger, H., Hu, H., Rančić, M. J., Zhang, J.-Y., …
Zhang, J.-J. (2020). Site-controlled uniform Ge/Si hut wires with electrically
tunable spin-orbit coupling. Advanced Materials. Wiley. https://doi.org/10.1002/adma.201906523
chicago: Gao, Fei, Jian-Huan Wang, Hannes Watzinger, Hao Hu, Marko J. Rančić, Jie-Yin
Zhang, Ting Wang, et al. “Site-Controlled Uniform Ge/Si Hut Wires with Electrically
Tunable Spin-Orbit Coupling.” Advanced Materials. Wiley, 2020. https://doi.org/10.1002/adma.201906523.
ieee: F. Gao et al., “Site-controlled uniform Ge/Si hut wires with electrically
tunable spin-orbit coupling,” Advanced Materials, vol. 32, no. 16. Wiley,
2020.
ista: Gao F, Wang J-H, Watzinger H, Hu H, Rančić MJ, Zhang J-Y, Wang T, Yao Y, Wang
G-L, Kukucka J, Vukušić L, Kloeffel C, Loss D, Liu F, Katsaros G, Zhang J-J. 2020.
Site-controlled uniform Ge/Si hut wires with electrically tunable spin-orbit coupling.
Advanced Materials. 32(16), 1906523.
mla: Gao, Fei, et al. “Site-Controlled Uniform Ge/Si Hut Wires with Electrically
Tunable Spin-Orbit Coupling.” Advanced Materials, vol. 32, no. 16, 1906523,
Wiley, 2020, doi:10.1002/adma.201906523.
short: F. Gao, J.-H. Wang, H. Watzinger, H. Hu, M.J. Rančić, J.-Y. Zhang, T. Wang,
Y. Yao, G.-L. Wang, J. Kukucka, L. Vukušić, C. Kloeffel, D. Loss, F. Liu, G. Katsaros,
J.-J. Zhang, Advanced Materials 32 (2020).
date_created: 2020-02-28T09:47:00Z
date_published: 2020-04-23T00:00:00Z
date_updated: 2024-02-21T12:42:12Z
day: '23'
ddc:
- '530'
department:
- _id: GeKa
doi: 10.1002/adma.201906523
ec_funded: 1
external_id:
isi:
- '000516660900001'
file:
- access_level: open_access
checksum: c622737dc295972065782558337124a2
content_type: application/pdf
creator: dernst
date_created: 2020-11-20T10:11:35Z
date_updated: 2020-11-20T10:11:35Z
file_id: '8782'
file_name: 2020_AdvancedMaterials_Gao.pdf
file_size: 5242880
relation: main_file
success: 1
file_date_updated: 2020-11-20T10:11:35Z
has_accepted_license: '1'
intvolume: ' 32'
isi: 1
issue: '16'
language:
- iso: eng
month: '04'
oa: 1
oa_version: Published Version
project:
- _id: 25517E86-B435-11E9-9278-68D0E5697425
call_identifier: FP7
grant_number: '335497'
name: Towards Spin qubits and Majorana fermions in Germanium selfassembled hut-wires
- _id: 237B3DA4-32DE-11EA-91FC-C7463DDC885E
call_identifier: FWF
grant_number: P32235
name: Towards scalable hut wire quantum devices
- _id: 237E5020-32DE-11EA-91FC-C7463DDC885E
call_identifier: H2020
grant_number: '862046'
name: TOPOLOGICALLY PROTECTED AND SCALABLE QUANTUM BITS
publication: Advanced Materials
publication_identifier:
issn:
- 0935-9648
publication_status: published
publisher: Wiley
quality_controlled: '1'
related_material:
record:
- id: '7996'
relation: dissertation_contains
status: public
- id: '9222'
relation: research_data
status: public
scopus_import: '1'
status: public
title: Site-controlled uniform Ge/Si hut wires with electrically tunable spin-orbit
coupling
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 32
year: '2020'
...
---
_id: '7546'
abstract:
- lang: eng
text: The extent to which behavior is shaped by experience varies between individuals.
Genetic differences contribute to this variation, but the neural mechanisms are
not understood. Here, we dissect natural variation in the behavioral flexibility
of two Caenorhabditis elegans wild strains. In one strain, a memory of exposure
to 21% O2 suppresses CO2-evoked locomotory arousal; in the other, CO2 evokes arousal
regardless of previous O2 experience. We map that variation to a polymorphic dendritic
scaffold protein, ARCP-1, expressed in sensory neurons. ARCP-1 binds the Ca2+-dependent
phosphodiesterase PDE-1 and co-localizes PDE-1 with molecular sensors for CO2
at dendritic ends. Reducing ARCP-1 or PDE-1 activity promotes CO2 escape by altering
neuropeptide expression in the BAG CO2 sensors. Variation in ARCP-1 alters behavioral
plasticity in multiple paradigms. Our findings are reminiscent of genetic accommodation,
an evolutionary process by which phenotypic flexibility in response to environmental
variation is reset by genetic change.
article_processing_charge: No
article_type: original
author:
- first_name: Isabel
full_name: Beets, Isabel
last_name: Beets
- first_name: Gaotian
full_name: Zhang, Gaotian
last_name: Zhang
- first_name: Lorenz A.
full_name: Fenk, Lorenz A.
last_name: Fenk
- first_name: Changchun
full_name: Chen, Changchun
last_name: Chen
- first_name: Geoffrey M.
full_name: Nelson, Geoffrey M.
last_name: Nelson
- first_name: Marie-Anne
full_name: Félix, Marie-Anne
last_name: Félix
- first_name: Mario
full_name: de Bono, Mario
id: 4E3FF80E-F248-11E8-B48F-1D18A9856A87
last_name: de Bono
orcid: 0000-0001-8347-0443
citation:
ama: Beets I, Zhang G, Fenk LA, et al. Natural variation in a dendritic scaffold
protein remodels experience-dependent plasticity by altering neuropeptide expression.
Neuron. 2020;105(1):106-121.e10. doi:10.1016/j.neuron.2019.10.001
apa: Beets, I., Zhang, G., Fenk, L. A., Chen, C., Nelson, G. M., Félix, M.-A., &
de Bono, M. (2020). Natural variation in a dendritic scaffold protein remodels
experience-dependent plasticity by altering neuropeptide expression. Neuron.
Cell Press. https://doi.org/10.1016/j.neuron.2019.10.001
chicago: Beets, Isabel, Gaotian Zhang, Lorenz A. Fenk, Changchun Chen, Geoffrey
M. Nelson, Marie-Anne Félix, and Mario de Bono. “Natural Variation in a Dendritic
Scaffold Protein Remodels Experience-Dependent Plasticity by Altering Neuropeptide
Expression.” Neuron. Cell Press, 2020. https://doi.org/10.1016/j.neuron.2019.10.001.
ieee: I. Beets et al., “Natural variation in a dendritic scaffold protein
remodels experience-dependent plasticity by altering neuropeptide expression,”
Neuron, vol. 105, no. 1. Cell Press, p. 106–121.e10, 2020.
ista: Beets I, Zhang G, Fenk LA, Chen C, Nelson GM, Félix M-A, de Bono M. 2020.
Natural variation in a dendritic scaffold protein remodels experience-dependent
plasticity by altering neuropeptide expression. Neuron. 105(1), 106–121.e10.
mla: Beets, Isabel, et al. “Natural Variation in a Dendritic Scaffold Protein Remodels
Experience-Dependent Plasticity by Altering Neuropeptide Expression.” Neuron,
vol. 105, no. 1, Cell Press, 2020, p. 106–121.e10, doi:10.1016/j.neuron.2019.10.001.
short: I. Beets, G. Zhang, L.A. Fenk, C. Chen, G.M. Nelson, M.-A. Félix, M. de Bono,
Neuron 105 (2020) 106–121.e10.
date_created: 2020-02-28T10:43:39Z
date_published: 2020-01-08T00:00:00Z
date_updated: 2023-08-18T06:46:23Z
day: '08'
ddc:
- '570'
department:
- _id: MaDe
doi: 10.1016/j.neuron.2019.10.001
external_id:
isi:
- '000507341300012'
pmid:
- '31757604'
file:
- access_level: open_access
checksum: 799bfd297a008753a688b30d3958fa48
content_type: application/pdf
creator: dernst
date_created: 2020-03-02T15:43:57Z
date_updated: 2020-07-14T12:48:00Z
file_id: '7558'
file_name: 2020_Neuron_Beets.pdf
file_size: 3294066
relation: main_file
file_date_updated: 2020-07-14T12:48:00Z
has_accepted_license: '1'
intvolume: ' 105'
isi: 1
issue: '1'
language:
- iso: eng
month: '01'
oa: 1
oa_version: Published Version
page: 106-121.e10
pmid: 1
publication: Neuron
publication_identifier:
issn:
- 0896-6273
publication_status: published
publisher: Cell Press
quality_controlled: '1'
status: public
title: Natural variation in a dendritic scaffold protein remodels experience-dependent
plasticity by altering neuropeptide expression
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 105
year: '2020'
...
---
_id: '7554'
abstract:
- lang: eng
text: Slicing a Voronoi tessellation in ${R}^n$ with a $k$-plane gives a $k$-dimensional
weighted Voronoi tessellation, also known as a power diagram or Laguerre tessellation.
Mapping every simplex of the dual weighted Delaunay mosaic to the radius of the
smallest empty circumscribed sphere whose center lies in the $k$-plane gives a
generalized discrete Morse function. Assuming the Voronoi tessellation is generated
by a Poisson point process in ${R}^n$, we study the expected number of simplices
in the $k$-dimensional weighted Delaunay mosaic as well as the expected number
of intervals of the Morse function, both as functions of a radius threshold. As
a by-product, we obtain a new proof for the expected number of connected components
(clumps) in a line section of a circular Boolean model in ${R}^n$.
article_processing_charge: No
article_type: original
arxiv: 1
author:
- first_name: Herbert
full_name: Edelsbrunner, Herbert
id: 3FB178DA-F248-11E8-B48F-1D18A9856A87
last_name: Edelsbrunner
orcid: 0000-0002-9823-6833
- first_name: Anton
full_name: Nikitenko, Anton
id: 3E4FF1BA-F248-11E8-B48F-1D18A9856A87
last_name: Nikitenko
orcid: 0000-0002-0659-3201
citation:
ama: Edelsbrunner H, Nikitenko A. Weighted Poisson–Delaunay mosaics. Theory of
Probability and its Applications. 2020;64(4):595-614. doi:10.1137/S0040585X97T989726
apa: Edelsbrunner, H., & Nikitenko, A. (2020). Weighted Poisson–Delaunay mosaics.
Theory of Probability and Its Applications. SIAM. https://doi.org/10.1137/S0040585X97T989726
chicago: Edelsbrunner, Herbert, and Anton Nikitenko. “Weighted Poisson–Delaunay
Mosaics.” Theory of Probability and Its Applications. SIAM, 2020. https://doi.org/10.1137/S0040585X97T989726.
ieee: H. Edelsbrunner and A. Nikitenko, “Weighted Poisson–Delaunay mosaics,” Theory
of Probability and its Applications, vol. 64, no. 4. SIAM, pp. 595–614, 2020.
ista: Edelsbrunner H, Nikitenko A. 2020. Weighted Poisson–Delaunay mosaics. Theory
of Probability and its Applications. 64(4), 595–614.
mla: Edelsbrunner, Herbert, and Anton Nikitenko. “Weighted Poisson–Delaunay Mosaics.”
Theory of Probability and Its Applications, vol. 64, no. 4, SIAM, 2020,
pp. 595–614, doi:10.1137/S0040585X97T989726.
short: H. Edelsbrunner, A. Nikitenko, Theory of Probability and Its Applications
64 (2020) 595–614.
date_created: 2020-03-01T23:00:39Z
date_published: 2020-02-13T00:00:00Z
date_updated: 2023-08-18T06:45:48Z
day: '13'
department:
- _id: HeEd
doi: 10.1137/S0040585X97T989726
ec_funded: 1
external_id:
arxiv:
- '1705.08735'
isi:
- '000551393100007'
intvolume: ' 64'
isi: 1
issue: '4'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://arxiv.org/abs/1705.08735
month: '02'
oa: 1
oa_version: Preprint
page: 595-614
project:
- _id: 266A2E9E-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '788183'
name: Alpha Shape Theory Extended
- _id: 2561EBF4-B435-11E9-9278-68D0E5697425
call_identifier: FWF
grant_number: I02979-N35
name: Persistence and stability of geometric complexes
publication: Theory of Probability and its Applications
publication_identifier:
eissn:
- '10957219'
issn:
- 0040585X
publication_status: published
publisher: SIAM
quality_controlled: '1'
scopus_import: '1'
status: public
title: Weighted Poisson–Delaunay mosaics
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 64
year: '2020'
...
---
_id: '7563'
abstract:
- lang: eng
text: "We introduce “state space persistence analysis” for deducing the symbolic
dynamics of time series data obtained from high-dimensional chaotic attractors.
To this end, we adapt a topological data analysis technique known as persistent
homology for the characterization of state space projections of chaotic trajectories
and periodic orbits. By comparing the shapes along a chaotic trajectory to those
of the periodic orbits, state space persistence analysis quantifies the shape
similarity of chaotic trajectory segments and periodic orbits. We demonstrate
the method by applying it to the three-dimensional Rössler system and a 30-dimensional
discretization of the Kuramoto–Sivashinsky partial differential equation in (1+1)
dimensions.\r\nOne way of studying chaotic attractors systematically is through
their symbolic dynamics, in which one partitions the state space into qualitatively
different regions and assigns a symbol to each such region.1–3 This yields a “coarse-grained”
state space of the system, which can then be reduced to a Markov chain encoding
all possible transitions between the states of the system. While it is possible
to obtain the symbolic dynamics of low-dimensional chaotic systems with standard
tools such as Poincaré maps, when applied to high-dimensional systems such as
turbulent flows, these tools alone are not sufficient to determine symbolic dynamics.4,5
In this paper, we develop “state space persistence analysis” and demonstrate that
it can be utilized to infer the symbolic dynamics in very high-dimensional settings."
article_number: '033109'
article_processing_charge: No
article_type: original
arxiv: 1
author:
- first_name: Gökhan
full_name: Yalniz, Gökhan
id: 66E74FA2-D8BF-11E9-8249-8DE2E5697425
last_name: Yalniz
orcid: 0000-0002-8490-9312
- first_name: Nazmi B
full_name: Budanur, Nazmi B
id: 3EA1010E-F248-11E8-B48F-1D18A9856A87
last_name: Budanur
orcid: 0000-0003-0423-5010
citation:
ama: Yalniz G, Budanur NB. Inferring symbolic dynamics of chaotic flows from persistence.
Chaos. 2020;30(3). doi:10.1063/1.5122969
apa: Yalniz, G., & Budanur, N. B. (2020). Inferring symbolic dynamics of chaotic
flows from persistence. Chaos. AIP Publishing. https://doi.org/10.1063/1.5122969
chicago: Yalniz, Gökhan, and Nazmi B Budanur. “Inferring Symbolic Dynamics of Chaotic
Flows from Persistence.” Chaos. AIP Publishing, 2020. https://doi.org/10.1063/1.5122969.
ieee: G. Yalniz and N. B. Budanur, “Inferring symbolic dynamics of chaotic flows
from persistence,” Chaos, vol. 30, no. 3. AIP Publishing, 2020.
ista: Yalniz G, Budanur NB. 2020. Inferring symbolic dynamics of chaotic flows from
persistence. Chaos. 30(3), 033109.
mla: Yalniz, Gökhan, and Nazmi B. Budanur. “Inferring Symbolic Dynamics of Chaotic
Flows from Persistence.” Chaos, vol. 30, no. 3, 033109, AIP Publishing,
2020, doi:10.1063/1.5122969.
short: G. Yalniz, N.B. Budanur, Chaos 30 (2020).
date_created: 2020-03-04T08:06:25Z
date_published: 2020-03-03T00:00:00Z
date_updated: 2023-08-18T06:47:16Z
day: '03'
department:
- _id: BjHo
doi: 10.1063/1.5122969
external_id:
arxiv:
- '1910.04584'
isi:
- '000519254800002'
intvolume: ' 30'
isi: 1
issue: '3'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://doi.org/10.1063/1.5122969
month: '03'
oa: 1
oa_version: Published Version
publication: Chaos
publication_identifier:
eissn:
- 1089-7682
issn:
- 1054-1500
publication_status: published
publisher: AIP Publishing
quality_controlled: '1'
scopus_import: '1'
status: public
title: Inferring symbolic dynamics of chaotic flows from persistence
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 30
year: '2020'
...
---
_id: '7567'
abstract:
- lang: eng
text: Coxeter triangulations are triangulations of Euclidean space based on a single
simplex. By this we mean that given an individual simplex we can recover the entire
triangulation of Euclidean space by inductively reflecting in the faces of the
simplex. In this paper we establish that the quality of the simplices in all Coxeter
triangulations is O(1/d−−√) of the quality of regular simplex. We further investigate
the Delaunay property for these triangulations. Moreover, we consider an extension
of the Delaunay property, namely protection, which is a measure of non-degeneracy
of a Delaunay triangulation. In particular, one family of Coxeter triangulations
achieves the protection O(1/d2). We conjecture that both bounds are optimal for
triangulations in Euclidean space.
article_processing_charge: Yes (via OA deal)
article_type: original
author:
- first_name: Aruni
full_name: Choudhary, Aruni
last_name: Choudhary
- first_name: Siargey
full_name: Kachanovich, Siargey
last_name: Kachanovich
- first_name: Mathijs
full_name: Wintraecken, Mathijs
id: 307CFBC8-F248-11E8-B48F-1D18A9856A87
last_name: Wintraecken
orcid: 0000-0002-7472-2220
citation:
ama: Choudhary A, Kachanovich S, Wintraecken M. Coxeter triangulations have good
quality. Mathematics in Computer Science. 2020;14:141-176. doi:10.1007/s11786-020-00461-5
apa: Choudhary, A., Kachanovich, S., & Wintraecken, M. (2020). Coxeter triangulations
have good quality. Mathematics in Computer Science. Springer Nature. https://doi.org/10.1007/s11786-020-00461-5
chicago: Choudhary, Aruni, Siargey Kachanovich, and Mathijs Wintraecken. “Coxeter
Triangulations Have Good Quality.” Mathematics in Computer Science. Springer
Nature, 2020. https://doi.org/10.1007/s11786-020-00461-5.
ieee: A. Choudhary, S. Kachanovich, and M. Wintraecken, “Coxeter triangulations
have good quality,” Mathematics in Computer Science, vol. 14. Springer
Nature, pp. 141–176, 2020.
ista: Choudhary A, Kachanovich S, Wintraecken M. 2020. Coxeter triangulations have
good quality. Mathematics in Computer Science. 14, 141–176.
mla: Choudhary, Aruni, et al. “Coxeter Triangulations Have Good Quality.” Mathematics
in Computer Science, vol. 14, Springer Nature, 2020, pp. 141–76, doi:10.1007/s11786-020-00461-5.
short: A. Choudhary, S. Kachanovich, M. Wintraecken, Mathematics in Computer Science
14 (2020) 141–176.
date_created: 2020-03-05T13:30:18Z
date_published: 2020-03-01T00:00:00Z
date_updated: 2021-01-12T08:14:13Z
day: '01'
ddc:
- '510'
department:
- _id: HeEd
doi: 10.1007/s11786-020-00461-5
ec_funded: 1
file:
- access_level: open_access
checksum: 1d145f3ab50ccee735983cb89236e609
content_type: application/pdf
creator: dernst
date_created: 2020-11-20T10:18:02Z
date_updated: 2020-11-20T10:18:02Z
file_id: '8783'
file_name: 2020_MathCompScie_Choudhary.pdf
file_size: 872275
relation: main_file
success: 1
file_date_updated: 2020-11-20T10:18:02Z
has_accepted_license: '1'
intvolume: ' 14'
language:
- iso: eng
month: '03'
oa: 1
oa_version: Published Version
page: 141-176
project:
- _id: B67AFEDC-15C9-11EA-A837-991A96BB2854
name: IST Austria Open Access Fund
- _id: 260C2330-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '754411'
name: ISTplus - Postdoctoral Fellowships
publication: Mathematics in Computer Science
publication_identifier:
eissn:
- 1661-8289
issn:
- 1661-8270
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
scopus_import: '1'
status: public
title: Coxeter triangulations have good quality
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 14
year: '2020'
...
---
_id: '7569'
abstract:
- lang: eng
text: 'Genes differ in the frequency at which they are expressed and in the form
of regulation used to control their activity. In particular, positive or negative
regulation can lead to activation of a gene in response to an external signal.
Previous works proposed that the form of regulation of a gene correlates with
its frequency of usage: positive regulation when the gene is frequently expressed
and negative regulation when infrequently expressed. Such network design means
that, in the absence of their regulators, the genes are found in their least required
activity state, hence regulatory intervention is often necessary. Due to the multitude
of genes and regulators, spurious binding and unbinding events, called “crosstalk”,
could occur. To determine how the form of regulation affects the global crosstalk
in the network, we used a mathematical model that includes multiple regulators
and multiple target genes. We found that crosstalk depends non-monotonically on
the availability of regulators. Our analysis showed that excess use of regulation
entailed by the formerly suggested network design caused high crosstalk levels
in a large part of the parameter space. We therefore considered the opposite ‘idle’
design, where the default unregulated state of genes is their frequently required
activity state. We found, that ‘idle’ design minimized the use of regulation and
thus minimized crosstalk. In addition, we estimated global crosstalk of S. cerevisiae
using transcription factors binding data. We demonstrated that even partial network
data could suffice to estimate its global crosstalk, suggesting its applicability
to additional organisms. We found that S. cerevisiae estimated crosstalk is lower
than that of a random network, suggesting that natural selection reduces crosstalk.
In summary, our study highlights a new type of protein production cost which is
typically overlooked: that of regulatory interference caused by the presence of
excess regulators in the cell. It demonstrates the importance of whole-network
descriptions, which could show effects missed by single-gene models.'
article_number: e1007642
article_processing_charge: No
article_type: original
author:
- first_name: Rok
full_name: Grah, Rok
id: 483E70DE-F248-11E8-B48F-1D18A9856A87
last_name: Grah
orcid: 0000-0003-2539-3560
- first_name: Tamar
full_name: Friedlander, Tamar
last_name: Friedlander
citation:
ama: Grah R, Friedlander T. The relation between crosstalk and gene regulation form
revisited. PLOS Computational Biology. 2020;16(2). doi:10.1371/journal.pcbi.1007642
apa: Grah, R., & Friedlander, T. (2020). The relation between crosstalk and
gene regulation form revisited. PLOS Computational Biology. Public Library
of Science. https://doi.org/10.1371/journal.pcbi.1007642
chicago: Grah, Rok, and Tamar Friedlander. “The Relation between Crosstalk and Gene
Regulation Form Revisited.” PLOS Computational Biology. Public Library
of Science, 2020. https://doi.org/10.1371/journal.pcbi.1007642.
ieee: R. Grah and T. Friedlander, “The relation between crosstalk and gene regulation
form revisited,” PLOS Computational Biology, vol. 16, no. 2. Public Library
of Science, 2020.
ista: Grah R, Friedlander T. 2020. The relation between crosstalk and gene regulation
form revisited. PLOS Computational Biology. 16(2), e1007642.
mla: Grah, Rok, and Tamar Friedlander. “The Relation between Crosstalk and Gene
Regulation Form Revisited.” PLOS Computational Biology, vol. 16, no. 2,
e1007642, Public Library of Science, 2020, doi:10.1371/journal.pcbi.1007642.
short: R. Grah, T. Friedlander, PLOS Computational Biology 16 (2020).
date_created: 2020-03-06T07:39:38Z
date_published: 2020-02-25T00:00:00Z
date_updated: 2023-09-12T11:02:24Z
day: '25'
ddc:
- '000'
- '570'
department:
- _id: CaGu
- _id: GaTk
doi: 10.1371/journal.pcbi.1007642
external_id:
isi:
- '000526725200019'
file:
- access_level: open_access
checksum: 5239dd134dc6e1c71fe7b3ce2953da37
content_type: application/pdf
creator: dernst
date_created: 2020-03-09T15:12:21Z
date_updated: 2020-07-14T12:48:00Z
file_id: '7579'
file_name: 2020_PlosCompBio_Grah.pdf
file_size: 2209325
relation: main_file
file_date_updated: 2020-07-14T12:48:00Z
has_accepted_license: '1'
intvolume: ' 16'
isi: 1
issue: '2'
language:
- iso: eng
month: '02'
oa: 1
oa_version: Published Version
publication: PLOS Computational Biology
publication_identifier:
issn:
- 1553-7358
publication_status: published
publisher: Public Library of Science
quality_controlled: '1'
related_material:
record:
- id: '9716'
relation: research_data
status: deleted
- id: '9776'
relation: research_data
status: public
- id: '9779'
relation: used_in_publication
status: public
- id: '8155'
relation: dissertation_contains
status: public
- id: '9777'
relation: research_data
status: public
scopus_import: '1'
status: public
title: The relation between crosstalk and gene regulation form revisited
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 16
year: '2020'
...
---
_id: '7570'
abstract:
- lang: eng
text: The relaxation of few-body quantum systems can strongly depend on the initial
state when the system’s semiclassical phase space is mixed; i.e., regions of chaotic
motion coexist with regular islands. In recent years, there has been much effort
to understand the process of thermalization in strongly interacting quantum systems
that often lack an obvious semiclassical limit. The time-dependent variational
principle (TDVP) allows one to systematically derive an effective classical (nonlinear)
dynamical system by projecting unitary many-body dynamics onto a manifold of weakly
entangled variational states. We demonstrate that such dynamical systems generally
possess mixed phase space. When TDVP errors are small, the mixed phase space leaves
a footprint on the exact dynamics of the quantum model. For example, when the
system is initialized in a state belonging to a stable periodic orbit or the surrounding
regular region, it exhibits persistent many-body quantum revivals. As a proof
of principle, we identify new types of “quantum many-body scars,” i.e., initial
states that lead to long-time oscillations in a model of interacting Rydberg atoms
in one and two dimensions. Intriguingly, the initial states that give rise to
most robust revivals are typically entangled states. On the other hand, even when
TDVP errors are large, as in the thermalizing tilted-field Ising model, initializing
the system in a regular region of phase space leads to a surprising slowdown of
thermalization. Our work establishes TDVP as a method for identifying interacting
quantum systems with anomalous dynamics in arbitrary dimensions. Moreover, the
mixed phase space classical variational equations allow one to find slowly thermalizing
initial conditions in interacting models. Our results shed light on a link between
classical and quantum chaos, pointing toward possible extensions of the classical
Kolmogorov-Arnold-Moser theorem to quantum systems.
article_number: '011055'
article_processing_charge: No
article_type: original
arxiv: 1
author:
- first_name: Alexios
full_name: Michailidis, Alexios
id: 36EBAD38-F248-11E8-B48F-1D18A9856A87
last_name: Michailidis
orcid: 0000-0002-8443-1064
- first_name: C. J.
full_name: Turner, C. J.
last_name: Turner
- first_name: Z.
full_name: Papić, Z.
last_name: Papić
- first_name: D. A.
full_name: Abanin, D. A.
last_name: Abanin
- first_name: Maksym
full_name: Serbyn, Maksym
id: 47809E7E-F248-11E8-B48F-1D18A9856A87
last_name: Serbyn
orcid: 0000-0002-2399-5827
citation:
ama: Michailidis A, Turner CJ, Papić Z, Abanin DA, Serbyn M. Slow quantum thermalization
and many-body revivals from mixed phase space. Physical Review X. 2020;10(1).
doi:10.1103/physrevx.10.011055
apa: Michailidis, A., Turner, C. J., Papić, Z., Abanin, D. A., & Serbyn, M.
(2020). Slow quantum thermalization and many-body revivals from mixed phase space.
Physical Review X. American Physical Society. https://doi.org/10.1103/physrevx.10.011055
chicago: Michailidis, Alexios, C. J. Turner, Z. Papić, D. A. Abanin, and Maksym
Serbyn. “Slow Quantum Thermalization and Many-Body Revivals from Mixed Phase Space.”
Physical Review X. American Physical Society, 2020. https://doi.org/10.1103/physrevx.10.011055.
ieee: A. Michailidis, C. J. Turner, Z. Papić, D. A. Abanin, and M. Serbyn, “Slow
quantum thermalization and many-body revivals from mixed phase space,” Physical
Review X, vol. 10, no. 1. American Physical Society, 2020.
ista: Michailidis A, Turner CJ, Papić Z, Abanin DA, Serbyn M. 2020. Slow quantum
thermalization and many-body revivals from mixed phase space. Physical Review
X. 10(1), 011055.
mla: Michailidis, Alexios, et al. “Slow Quantum Thermalization and Many-Body Revivals
from Mixed Phase Space.” Physical Review X, vol. 10, no. 1, 011055, American
Physical Society, 2020, doi:10.1103/physrevx.10.011055.
short: A. Michailidis, C.J. Turner, Z. Papić, D.A. Abanin, M. Serbyn, Physical Review
X 10 (2020).
date_created: 2020-03-08T18:02:01Z
date_published: 2020-03-04T00:00:00Z
date_updated: 2023-08-18T07:01:07Z
day: '04'
ddc:
- '530'
department:
- _id: MaSe
doi: 10.1103/physrevx.10.011055
external_id:
arxiv:
- '1905.08564'
isi:
- '000517969300001'
file:
- access_level: open_access
checksum: 4b3f2c13873d35230173c73d0e11c408
content_type: application/pdf
creator: dernst
date_created: 2020-03-12T12:13:07Z
date_updated: 2020-07-14T12:48:00Z
file_id: '7581'
file_name: 2020_PhysicalReviewX_Michailidis.pdf
file_size: 17828638
relation: main_file
file_date_updated: 2020-07-14T12:48:00Z
has_accepted_license: '1'
intvolume: ' 10'
isi: 1
issue: '1'
language:
- iso: eng
month: '03'
oa: 1
oa_version: Published Version
publication: Physical Review X
publication_identifier:
issn:
- 2160-3308
publication_status: published
publisher: American Physical Society
quality_controlled: '1'
related_material:
link:
- description: News on IST Homepage
relation: press_release
url: https://ist.ac.at/en/news/classical-physics-helps-predict-fate-of-interacting-quantum-systems/
scopus_import: '1'
status: public
title: Slow quantum thermalization and many-body revivals from mixed phase space
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 10
year: '2020'
...
---
_id: '7572'
abstract:
- lang: eng
text: The polymerization–depolymerization dynamics of cytoskeletal proteins play
essential roles in the self-organization of cytoskeletal structures, in eukaryotic
as well as prokaryotic cells. While advances in fluorescence microscopy and in
vitro reconstitution experiments have helped to study the dynamic properties of
these complex systems, methods that allow to collect and analyze large quantitative
datasets of the underlying polymer dynamics are still missing. Here, we present
a novel image analysis workflow to study polymerization dynamics of active filaments
in a nonbiased, highly automated manner. Using treadmilling filaments of the bacterial
tubulin FtsZ as an example, we demonstrate that our method is able to specifically
detect, track and analyze growth and shrinkage of polymers, even in dense networks
of filaments. We believe that this automated method can facilitate the analysis
of a large variety of dynamic cytoskeletal systems, using standard time-lapse
movies obtained from experiments in vitro as well as in the living cell. Moreover,
we provide scripts implementing this method as supplementary material.
alternative_title:
- Methods in Cell Biology
article_processing_charge: No
author:
- first_name: Paulo R
full_name: Dos Santos Caldas, Paulo R
id: 38FCDB4C-F248-11E8-B48F-1D18A9856A87
last_name: Dos Santos Caldas
orcid: 0000-0001-6730-4461
- first_name: Philipp
full_name: Radler, Philipp
id: 40136C2A-F248-11E8-B48F-1D18A9856A87
last_name: Radler
orcid: '0000-0001-9198-2182 '
- first_name: Christoph M
full_name: Sommer, Christoph M
id: 4DF26D8C-F248-11E8-B48F-1D18A9856A87
last_name: Sommer
orcid: 0000-0003-1216-9105
- first_name: Martin
full_name: Loose, Martin
id: 462D4284-F248-11E8-B48F-1D18A9856A87
last_name: Loose
orcid: 0000-0001-7309-9724
citation:
ama: 'Dos Santos Caldas PR, Radler P, Sommer CM, Loose M. Computational analysis
of filament polymerization dynamics in cytoskeletal networks. In: Tran P, ed.
Methods in Cell Biology. Vol 158. Elsevier; 2020:145-161. doi:10.1016/bs.mcb.2020.01.006'
apa: Dos Santos Caldas, P. R., Radler, P., Sommer, C. M., & Loose, M. (2020).
Computational analysis of filament polymerization dynamics in cytoskeletal networks.
In P. Tran (Ed.), Methods in Cell Biology (Vol. 158, pp. 145–161). Elsevier.
https://doi.org/10.1016/bs.mcb.2020.01.006
chicago: Dos Santos Caldas, Paulo R, Philipp Radler, Christoph M Sommer, and Martin
Loose. “Computational Analysis of Filament Polymerization Dynamics in Cytoskeletal
Networks.” In Methods in Cell Biology, edited by Phong Tran, 158:145–61.
Elsevier, 2020. https://doi.org/10.1016/bs.mcb.2020.01.006.
ieee: P. R. Dos Santos Caldas, P. Radler, C. M. Sommer, and M. Loose, “Computational
analysis of filament polymerization dynamics in cytoskeletal networks,” in Methods
in Cell Biology, vol. 158, P. Tran, Ed. Elsevier, 2020, pp. 145–161.
ista: 'Dos Santos Caldas PR, Radler P, Sommer CM, Loose M. 2020.Computational analysis
of filament polymerization dynamics in cytoskeletal networks. In: Methods in Cell
Biology. Methods in Cell Biology, vol. 158, 145–161.'
mla: Dos Santos Caldas, Paulo R., et al. “Computational Analysis of Filament Polymerization
Dynamics in Cytoskeletal Networks.” Methods in Cell Biology, edited by
Phong Tran, vol. 158, Elsevier, 2020, pp. 145–61, doi:10.1016/bs.mcb.2020.01.006.
short: P.R. Dos Santos Caldas, P. Radler, C.M. Sommer, M. Loose, in:, P. Tran (Ed.),
Methods in Cell Biology, Elsevier, 2020, pp. 145–161.
date_created: 2020-03-08T23:00:47Z
date_published: 2020-02-27T00:00:00Z
date_updated: 2023-10-04T09:50:24Z
day: '27'
department:
- _id: MaLo
doi: 10.1016/bs.mcb.2020.01.006
ec_funded: 1
editor:
- first_name: 'Phong '
full_name: 'Tran, Phong '
last_name: Tran
external_id:
isi:
- '000611826500008'
intvolume: ' 158'
isi: 1
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://doi.org/10.1101/839571
month: '02'
oa: 1
oa_version: Preprint
page: 145-161
project:
- _id: 2595697A-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '679239'
name: Self-Organization of the Bacterial Cell
- _id: 260D98C8-B435-11E9-9278-68D0E5697425
name: Reconstitution of Bacterial Cell Division Using Purified Components
publication: Methods in Cell Biology
publication_identifier:
issn:
- 0091679X
publication_status: published
publisher: Elsevier
quality_controlled: '1'
related_material:
record:
- id: '8358'
relation: part_of_dissertation
status: public
scopus_import: '1'
status: public
title: Computational analysis of filament polymerization dynamics in cytoskeletal
networks
type: book_chapter
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 158
year: '2020'
...
---
_id: '7573'
abstract:
- lang: eng
text: This paper deals with dynamical optimal transport metrics defined by spatial
discretisation of the Benamou–Benamou formula for the Kantorovich metric . Such
metrics appear naturally in discretisations of -gradient flow formulations for
dissipative PDE. However, it has recently been shown that these metrics do not
in general converge to , unless strong geometric constraints are imposed on the
discrete mesh. In this paper we prove that, in a 1-dimensional periodic setting,
discrete transport metrics converge to a limiting transport metric with a non-trivial
effective mobility. This mobility depends sensitively on the geometry of the mesh
and on the non-local mobility at the discrete level. Our result quantifies to
what extent discrete transport can make use of microstructure in the mesh to reduce
the cost of transport.
acknowledgement: J.M. gratefully acknowledges support by the European Research Council
(ERC) under the European Union's Horizon 2020 research and innovation programme
(grant agreement No 716117). J.M. and L.P. also acknowledge support from the Austrian
Science Fund (FWF), grants No F65 and W1245. E.K. gratefully acknowledges support
by the German Research Foundation through the Hausdorff Center for Mathematics and
the Collaborative Research Center 1060. P.G. is partially funded by the Deutsche
Forschungsgemeinschaft (DFG, German Research Foundation) – 350398276.
article_processing_charge: No
article_type: original
arxiv: 1
author:
- first_name: Peter
full_name: Gladbach, Peter
last_name: Gladbach
- first_name: Eva
full_name: Kopfer, Eva
last_name: Kopfer
- first_name: Jan
full_name: Maas, Jan
id: 4C5696CE-F248-11E8-B48F-1D18A9856A87
last_name: Maas
orcid: 0000-0002-0845-1338
- first_name: Lorenzo
full_name: Portinale, Lorenzo
id: 30AD2CBC-F248-11E8-B48F-1D18A9856A87
last_name: Portinale
citation:
ama: Gladbach P, Kopfer E, Maas J, Portinale L. Homogenisation of one-dimensional
discrete optimal transport. Journal de Mathematiques Pures et Appliquees.
2020;139(7):204-234. doi:10.1016/j.matpur.2020.02.008
apa: Gladbach, P., Kopfer, E., Maas, J., & Portinale, L. (2020). Homogenisation
of one-dimensional discrete optimal transport. Journal de Mathematiques Pures
et Appliquees. Elsevier. https://doi.org/10.1016/j.matpur.2020.02.008
chicago: Gladbach, Peter, Eva Kopfer, Jan Maas, and Lorenzo Portinale. “Homogenisation
of One-Dimensional Discrete Optimal Transport.” Journal de Mathematiques Pures
et Appliquees. Elsevier, 2020. https://doi.org/10.1016/j.matpur.2020.02.008.
ieee: P. Gladbach, E. Kopfer, J. Maas, and L. Portinale, “Homogenisation of one-dimensional
discrete optimal transport,” Journal de Mathematiques Pures et Appliquees,
vol. 139, no. 7. Elsevier, pp. 204–234, 2020.
ista: Gladbach P, Kopfer E, Maas J, Portinale L. 2020. Homogenisation of one-dimensional
discrete optimal transport. Journal de Mathematiques Pures et Appliquees. 139(7),
204–234.
mla: Gladbach, Peter, et al. “Homogenisation of One-Dimensional Discrete Optimal
Transport.” Journal de Mathematiques Pures et Appliquees, vol. 139, no.
7, Elsevier, 2020, pp. 204–34, doi:10.1016/j.matpur.2020.02.008.
short: P. Gladbach, E. Kopfer, J. Maas, L. Portinale, Journal de Mathematiques Pures
et Appliquees 139 (2020) 204–234.
date_created: 2020-03-08T23:00:47Z
date_published: 2020-07-01T00:00:00Z
date_updated: 2023-09-07T13:31:05Z
day: '01'
department:
- _id: JaMa
doi: 10.1016/j.matpur.2020.02.008
ec_funded: 1
external_id:
arxiv:
- '1905.05757'
isi:
- '000539439400008'
intvolume: ' 139'
isi: 1
issue: '7'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://arxiv.org/abs/1905.05757
month: '07'
oa: 1
oa_version: Preprint
page: 204-234
project:
- _id: 256E75B8-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '716117'
name: Optimal Transport and Stochastic Dynamics
- _id: 260482E2-B435-11E9-9278-68D0E5697425
call_identifier: FWF
grant_number: ' F06504'
name: Taming Complexity in Partial Di erential Systems
- _id: 260788DE-B435-11E9-9278-68D0E5697425
call_identifier: FWF
name: Dissipation and Dispersion in Nonlinear Partial Differential Equations
publication: Journal de Mathematiques Pures et Appliquees
publication_identifier:
issn:
- '00217824'
publication_status: published
publisher: Elsevier
quality_controlled: '1'
related_material:
record:
- id: '10030'
relation: dissertation_contains
status: public
scopus_import: '1'
status: public
title: Homogenisation of one-dimensional discrete optimal transport
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 139
year: '2020'
...
---
_id: '7580'
abstract:
- lang: eng
text: The eukaryotic endomembrane system is controlled by small GTPases of the Rab
family, which are activated at defined times and locations in a switch-like manner.
While this switch is well understood for an individual protein, how regulatory
networks produce intracellular activity patterns is currently not known. Here,
we combine in vitro reconstitution experiments with computational modeling to
study a minimal Rab5 activation network. We find that the molecular interactions
in this system give rise to a positive feedback and bistable collective switching
of Rab5. Furthermore, we find that switching near the critical point is intrinsically
stochastic and provide evidence that controlling the inactive population of Rab5
on the membrane can shape the network response. Notably, we demonstrate that collective
switching can spread on the membrane surface as a traveling wave of Rab5 activation.
Together, our findings reveal how biochemical signaling networks control vesicle
trafficking pathways and how their nonequilibrium properties define the spatiotemporal
organization of the cell.
acknowledged_ssus:
- _id: Bio
- _id: LifeSc
article_processing_charge: No
article_type: original
author:
- first_name: Urban
full_name: Bezeljak, Urban
id: 2A58201A-F248-11E8-B48F-1D18A9856A87
last_name: Bezeljak
orcid: 0000-0003-1365-5631
- first_name: Hrushikesh
full_name: Loya, Hrushikesh
last_name: Loya
- first_name: Beata M
full_name: Kaczmarek, Beata M
id: 36FA4AFA-F248-11E8-B48F-1D18A9856A87
last_name: Kaczmarek
- first_name: Timothy E.
full_name: Saunders, Timothy E.
last_name: Saunders
- first_name: Martin
full_name: Loose, Martin
id: 462D4284-F248-11E8-B48F-1D18A9856A87
last_name: Loose
orcid: 0000-0001-7309-9724
citation:
ama: Bezeljak U, Loya H, Kaczmarek BM, Saunders TE, Loose M. Stochastic activation
and bistability in a Rab GTPase regulatory network. Proceedings of the National
Academy of Sciences. 2020;117(12):6504-6549. doi:10.1073/pnas.1921027117
apa: Bezeljak, U., Loya, H., Kaczmarek, B. M., Saunders, T. E., & Loose, M.
(2020). Stochastic activation and bistability in a Rab GTPase regulatory network.
Proceedings of the National Academy of Sciences. Proceedings of the National
Academy of Sciences. https://doi.org/10.1073/pnas.1921027117
chicago: Bezeljak, Urban, Hrushikesh Loya, Beata M Kaczmarek, Timothy E. Saunders,
and Martin Loose. “Stochastic Activation and Bistability in a Rab GTPase Regulatory
Network.” Proceedings of the National Academy of Sciences. Proceedings
of the National Academy of Sciences, 2020. https://doi.org/10.1073/pnas.1921027117.
ieee: U. Bezeljak, H. Loya, B. M. Kaczmarek, T. E. Saunders, and M. Loose, “Stochastic
activation and bistability in a Rab GTPase regulatory network,” Proceedings
of the National Academy of Sciences, vol. 117, no. 12. Proceedings of the
National Academy of Sciences, pp. 6504–6549, 2020.
ista: Bezeljak U, Loya H, Kaczmarek BM, Saunders TE, Loose M. 2020. Stochastic activation
and bistability in a Rab GTPase regulatory network. Proceedings of the National
Academy of Sciences. 117(12), 6504–6549.
mla: Bezeljak, Urban, et al. “Stochastic Activation and Bistability in a Rab GTPase
Regulatory Network.” Proceedings of the National Academy of Sciences, vol.
117, no. 12, Proceedings of the National Academy of Sciences, 2020, pp. 6504–49,
doi:10.1073/pnas.1921027117.
short: U. Bezeljak, H. Loya, B.M. Kaczmarek, T.E. Saunders, M. Loose, Proceedings
of the National Academy of Sciences 117 (2020) 6504–6549.
date_created: 2020-03-12T05:32:26Z
date_published: 2020-03-24T00:00:00Z
date_updated: 2023-09-07T13:17:06Z
day: '24'
department:
- _id: MaLo
- _id: CaBe
doi: 10.1073/pnas.1921027117
external_id:
isi:
- '000521821800040'
intvolume: ' 117'
isi: 1
issue: '12'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://doi.org/10.1101/776567
month: '03'
oa: 1
oa_version: Preprint
page: 6504-6549
project:
- _id: 2599F062-B435-11E9-9278-68D0E5697425
grant_number: RGY0083/2016
name: Reconstitution of cell polarity and axis determination in a cell-free system
publication: Proceedings of the National Academy of Sciences
publication_identifier:
eissn:
- 1091-6490
issn:
- 0027-8424
publication_status: published
publisher: Proceedings of the National Academy of Sciences
quality_controlled: '1'
related_material:
link:
- description: News on IST Homepage
relation: press_release
url: https://ist.ac.at/en/news/proteins-as-molecular-switches/
record:
- id: '8341'
relation: dissertation_contains
status: public
scopus_import: '1'
status: public
title: Stochastic activation and bistability in a Rab GTPase regulatory network
type: journal_article
user_id: c635000d-4b10-11ee-a964-aac5a93f6ac1
volume: 117
year: '2020'
...
---
_id: '7582'
abstract:
- lang: eng
text: Small RNAs (smRNA, 19–25 nucleotides long), which are transcribed by RNA polymerase
II, regulate the expression of genes involved in a multitude of processes in eukaryotes.
miRNA biogenesis and the proteins involved in the biogenesis pathway differ across
plant and animal lineages. The major proteins constituting the biogenesis pathway,
namely, the Dicers (DCL/DCR) and Argonautes (AGOs), have been extensively studied.
However, the accessory proteins (DAWDLE (DDL), SERRATE (SE), and TOUGH (TGH))
of the pathway that differs across the two lineages remain largely uncharacterized.
We present the first detailed report on the molecular evolution and divergence
of these proteins across eukaryotes. Although DDL is present in eukaryotes and
prokaryotes, SE and TGH appear to be specific to eukaryotes. The addition/deletion
of specific domains and/or domain-specific sequence divergence in the three proteins
points to the observed functional divergence of these proteins across the two
lineages, which correlates with the differences in miRNA length across the two
lineages. Our data enhance the current understanding of the structure–function
relationship of these proteins and reveals previous unexplored crucial residues
in the three proteins that can be used as a basis for further functional characterization.
The data presented here on the number of miRNAs in crown eukaryotic lineages are
consistent with the notion of the expansion of the number of miRNA-coding genes
in animal and plant lineages correlating with organismal complexity. Whether this
difference in functionally correlates with the diversification (or presence/absence)
of the three proteins studied here or the miRNA signaling in the plant and animal
lineages is unclear. Based on our results of the three proteins studied here and
previously available data concerning the evolution of miRNA genes in the plant
and animal lineages, we believe that miRNAs probably evolved once in the ancestor
to crown eukaryotes and have diversified independently in the eukaryotes.
article_number: '299'
article_processing_charge: No
article_type: original
author:
- first_name: Taraka Ramji
full_name: Moturu, Taraka Ramji
last_name: Moturu
- first_name: Sansrity
full_name: Sinha, Sansrity
last_name: Sinha
- first_name: Hymavathi
full_name: Salava, Hymavathi
last_name: Salava
- first_name: Sravankumar
full_name: Thula, Sravankumar
last_name: Thula
- first_name: Tomasz
full_name: Nodzyński, Tomasz
last_name: Nodzyński
- first_name: Radka Svobodová
full_name: Vařeková, Radka Svobodová
last_name: Vařeková
- first_name: Jiří
full_name: Friml, Jiří
id: 4159519E-F248-11E8-B48F-1D18A9856A87
last_name: Friml
orcid: 0000-0002-8302-7596
- first_name: Sibu
full_name: Simon, Sibu
id: 4542EF9A-F248-11E8-B48F-1D18A9856A87
last_name: Simon
orcid: 0000-0002-1998-6741
citation:
ama: Moturu TR, Sinha S, Salava H, et al. Molecular evolution and diversification
of proteins involved in miRNA maturation pathway. Plants. 2020;9(3). doi:10.3390/plants9030299
apa: Moturu, T. R., Sinha, S., Salava, H., Thula, S., Nodzyński, T., Vařeková, R.
S., … Simon, S. (2020). Molecular evolution and diversification of proteins involved
in miRNA maturation pathway. Plants. MDPI. https://doi.org/10.3390/plants9030299
chicago: Moturu, Taraka Ramji, Sansrity Sinha, Hymavathi Salava, Sravankumar Thula,
Tomasz Nodzyński, Radka Svobodová Vařeková, Jiří Friml, and Sibu Simon. “Molecular
Evolution and Diversification of Proteins Involved in MiRNA Maturation Pathway.”
Plants. MDPI, 2020. https://doi.org/10.3390/plants9030299.
ieee: T. R. Moturu et al., “Molecular evolution and diversification of proteins
involved in miRNA maturation pathway,” Plants, vol. 9, no. 3. MDPI, 2020.
ista: Moturu TR, Sinha S, Salava H, Thula S, Nodzyński T, Vařeková RS, Friml J,
Simon S. 2020. Molecular evolution and diversification of proteins involved in
miRNA maturation pathway. Plants. 9(3), 299.
mla: Moturu, Taraka Ramji, et al. “Molecular Evolution and Diversification of Proteins
Involved in MiRNA Maturation Pathway.” Plants, vol. 9, no. 3, 299, MDPI,
2020, doi:10.3390/plants9030299.
short: T.R. Moturu, S. Sinha, H. Salava, S. Thula, T. Nodzyński, R.S. Vařeková,
J. Friml, S. Simon, Plants 9 (2020).
date_created: 2020-03-15T23:00:52Z
date_published: 2020-03-01T00:00:00Z
date_updated: 2025-05-07T11:12:28Z
day: '01'
ddc:
- '580'
department:
- _id: JiFr
doi: 10.3390/plants9030299
ec_funded: 1
external_id:
isi:
- '000525315000035'
pmid:
- '32121542'
file:
- access_level: open_access
checksum: 6d5af3e17266a48996b4af4e67e88a85
content_type: application/pdf
creator: dernst
date_created: 2020-03-23T13:37:00Z
date_updated: 2020-07-14T12:48:00Z
file_id: '7614'
file_name: 2020_Plants_Moturu.pdf
file_size: 2373484
relation: main_file
file_date_updated: 2020-07-14T12:48:00Z
has_accepted_license: '1'
intvolume: ' 9'
isi: 1
issue: '3'
language:
- iso: eng
month: '03'
oa: 1
oa_version: Published Version
pmid: 1
project:
- _id: 25716A02-B435-11E9-9278-68D0E5697425
call_identifier: FP7
grant_number: '282300'
name: Polarity and subcellular dynamics in plants
publication: Plants
publication_identifier:
eissn:
- '22237747'
publication_status: published
publisher: MDPI
quality_controlled: '1'
scopus_import: '1'
status: public
title: Molecular evolution and diversification of proteins involved in miRNA maturation
pathway
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 9
year: '2020'
...
---
_id: '7586'
abstract:
- lang: eng
text: CLC chloride/proton exchangers may support acidification of endolysosomes
and raise their luminal Cl− concentration. Disruption of endosomal ClC‐3 causes
severe neurodegeneration. To assess the importance of ClC‐3 Cl−/H+ exchange, we
now generate Clcn3unc/unc mice in which ClC‐3 is converted into a Cl− channel.
Unlike Clcn3−/− mice, Clcn3unc/unc mice appear normal owing to compensation by
ClC‐4 with which ClC‐3 forms heteromers. ClC‐4 protein levels are strongly reduced
in Clcn3−/−, but not in Clcn3unc/unc mice because ClC‐3unc binds and stabilizes
ClC‐4 like wild‐type ClC‐3. Although mice lacking ClC‐4 appear healthy, its absence
in Clcn3unc/unc/Clcn4−/− mice entails even stronger neurodegeneration than observed
in Clcn3−/− mice. A fraction of ClC‐3 is found on synaptic vesicles, but miniature
postsynaptic currents and synaptic vesicle acidification are not affected in Clcn3unc/unc
or Clcn3−/− mice before neurodegeneration sets in. Both, Cl−/H+‐exchange activity
and the stabilizing effect on ClC‐4, are central to the biological function of
ClC‐3.
acknowledgement: "We thank T. Stauber and T. Breiderhoff for cloning expression constructs;
K. Räbel, S. Hohensee, and C. Backhaus for technical assistance; R. Jahn (MPIbpc,
Göttingen) for providing the equipment required for SV purification; and A\r\nWoehler
(MDC, Berlin) for assistance with SV imaging. Supported, in part, by grants from
the Deutsche Forschungsgemeinschaft (JE164/9-2, SFB740 TP C5, FOR 2625 (JE164/14-1),
NeuroCure Cluster of Excellence), the European Research Council Advanced Grant CYTOVOLION
(ERC 294435) and the Prix Louis-Jeantet de Médecine to TJJ, and Peter and Traudl
Engelhorn fellowship to ZF."
article_number: e103358
article_processing_charge: No
article_type: original
author:
- first_name: Stefanie
full_name: Weinert, Stefanie
last_name: Weinert
- first_name: Niclas
full_name: Gimber, Niclas
last_name: Gimber
- first_name: Dorothea
full_name: Deuschel, Dorothea
last_name: Deuschel
- first_name: Till
full_name: Stuhlmann, Till
last_name: Stuhlmann
- first_name: Dmytro
full_name: Puchkov, Dmytro
last_name: Puchkov
- first_name: Zohreh
full_name: Farsi, Zohreh
last_name: Farsi
- first_name: Carmen F.
full_name: Ludwig, Carmen F.
last_name: Ludwig
- first_name: Gaia
full_name: Novarino, Gaia
id: 3E57A680-F248-11E8-B48F-1D18A9856A87
last_name: Novarino
orcid: 0000-0002-7673-7178
- first_name: Karen I.
full_name: López-Cayuqueo, Karen I.
last_name: López-Cayuqueo
- first_name: Rosa
full_name: Planells-Cases, Rosa
last_name: Planells-Cases
- first_name: Thomas J.
full_name: Jentsch, Thomas J.
last_name: Jentsch
citation:
ama: Weinert S, Gimber N, Deuschel D, et al. Uncoupling endosomal CLC chloride/proton
exchange causes severe neurodegeneration. EMBO Journal. 2020;39. doi:10.15252/embj.2019103358
apa: Weinert, S., Gimber, N., Deuschel, D., Stuhlmann, T., Puchkov, D., Farsi, Z.,
… Jentsch, T. J. (2020). Uncoupling endosomal CLC chloride/proton exchange causes
severe neurodegeneration. EMBO Journal. EMBO Press. https://doi.org/10.15252/embj.2019103358
chicago: Weinert, Stefanie, Niclas Gimber, Dorothea Deuschel, Till Stuhlmann, Dmytro
Puchkov, Zohreh Farsi, Carmen F. Ludwig, et al. “Uncoupling Endosomal CLC Chloride/Proton
Exchange Causes Severe Neurodegeneration.” EMBO Journal. EMBO Press, 2020.
https://doi.org/10.15252/embj.2019103358.
ieee: S. Weinert et al., “Uncoupling endosomal CLC chloride/proton exchange
causes severe neurodegeneration,” EMBO Journal, vol. 39. EMBO Press, 2020.
ista: Weinert S, Gimber N, Deuschel D, Stuhlmann T, Puchkov D, Farsi Z, Ludwig CF,
Novarino G, López-Cayuqueo KI, Planells-Cases R, Jentsch TJ. 2020. Uncoupling
endosomal CLC chloride/proton exchange causes severe neurodegeneration. EMBO Journal.
39, e103358.
mla: Weinert, Stefanie, et al. “Uncoupling Endosomal CLC Chloride/Proton Exchange
Causes Severe Neurodegeneration.” EMBO Journal, vol. 39, e103358, EMBO
Press, 2020, doi:10.15252/embj.2019103358.
short: S. Weinert, N. Gimber, D. Deuschel, T. Stuhlmann, D. Puchkov, Z. Farsi, C.F.
Ludwig, G. Novarino, K.I. López-Cayuqueo, R. Planells-Cases, T.J. Jentsch, EMBO
Journal 39 (2020).
date_created: 2020-03-15T23:00:55Z
date_published: 2020-03-02T00:00:00Z
date_updated: 2023-08-18T07:07:36Z
day: '02'
ddc:
- '570'
department:
- _id: GaNo
doi: 10.15252/embj.2019103358
external_id:
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title: Uncoupling endosomal CLC chloride/proton exchange causes severe neurodegeneration
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