---
_id: '12111'
abstract:
- lang: eng
text: Quantum impurities exhibit fascinating many-body phenomena when the small
interacting impurity changes the physics of a large noninteracting environment.
The characterisation of such strongly correlated nonperturbative effects is particularly
challenging due to the infinite size of the environment, and the inability of
local correlators to capture the buildup of long-ranged entanglement in the system.
Here, we harness an entanglement-based observable—the purity of the impurity—as
a witness for the formation of strong correlations. We showcase the utility of
our scheme by exactly solving the open Kondo box model in the small box limit,
and thus describe all-electronic dot-cavity devices. Specifically, we conclusively
characterize the metal-to-insulator phase transition in the system and identify
how the (conducting) dot-lead Kondo singlet is quenched by an (insulating) intraimpurity
singlet formation. Furthermore, we propose an experimentally feasible tomography
protocol for the measurement of the purity, which motivates the observation of
impurity physics through their entanglement build up.
acknowledgement: We thank G. Blatter, T. Ihn, K. Ensslin, M. Goldstein, C. Carisch,
and J. del Pino for illuminating discussions and acknowledge financial support from
the Swiss National Science Foundation (SNSF) through Project No. 190078, and from
the Deutsche Forschungsgemeinschaft (DFG) - Project No. 449653034. Our numerical
implementations are based on the ITensors JULIA library [64].
article_number: '043177'
article_processing_charge: No
article_type: original
author:
- first_name: Lidia
full_name: Stocker, Lidia
last_name: Stocker
- first_name: Stefan
full_name: Sack, Stefan
id: dd622248-f6e0-11ea-865d-ce382a1c81a5
last_name: Sack
- first_name: Michael S.
full_name: Ferguson, Michael S.
last_name: Ferguson
- first_name: Oded
full_name: Zilberberg, Oded
last_name: Zilberberg
citation:
ama: Stocker L, Sack S, Ferguson MS, Zilberberg O. Entanglement-based observables
for quantum impurities. Physical Review Research. 2022;4(4). doi:10.1103/PhysRevResearch.4.043177
apa: Stocker, L., Sack, S., Ferguson, M. S., & Zilberberg, O. (2022). Entanglement-based
observables for quantum impurities. Physical Review Research. American
Physical Society. https://doi.org/10.1103/PhysRevResearch.4.043177
chicago: Stocker, Lidia, Stefan Sack, Michael S. Ferguson, and Oded Zilberberg.
“Entanglement-Based Observables for Quantum Impurities.” Physical Review Research.
American Physical Society, 2022. https://doi.org/10.1103/PhysRevResearch.4.043177.
ieee: L. Stocker, S. Sack, M. S. Ferguson, and O. Zilberberg, “Entanglement-based
observables for quantum impurities,” Physical Review Research, vol. 4,
no. 4. American Physical Society, 2022.
ista: Stocker L, Sack S, Ferguson MS, Zilberberg O. 2022. Entanglement-based observables
for quantum impurities. Physical Review Research. 4(4), 043177.
mla: Stocker, Lidia, et al. “Entanglement-Based Observables for Quantum Impurities.”
Physical Review Research, vol. 4, no. 4, 043177, American Physical Society,
2022, doi:10.1103/PhysRevResearch.4.043177.
short: L. Stocker, S. Sack, M.S. Ferguson, O. Zilberberg, Physical Review Research
4 (2022).
date_created: 2023-01-08T23:00:53Z
date_published: 2022-12-01T00:00:00Z
date_updated: 2023-02-13T09:08:28Z
day: '01'
ddc:
- '530'
department:
- _id: MaSe
doi: 10.1103/PhysRevResearch.4.043177
file:
- access_level: open_access
checksum: 556820cf6e4af77c8476e5b8f4114d1a
content_type: application/pdf
creator: dernst
date_created: 2023-01-20T12:03:31Z
date_updated: 2023-01-20T12:03:31Z
file_id: '12328'
file_name: 2022_PhysicalReviewResearch_Stocker.pdf
file_size: 2941167
relation: main_file
success: 1
file_date_updated: 2023-01-20T12:03:31Z
has_accepted_license: '1'
intvolume: ' 4'
issue: '4'
language:
- iso: eng
month: '12'
oa: 1
oa_version: Published Version
publication: Physical Review Research
publication_identifier:
issn:
- 2643-1564
publication_status: published
publisher: American Physical Society
quality_controlled: '1'
scopus_import: '1'
status: public
title: Entanglement-based observables for quantum impurities
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 4
year: '2022'
...
---
_id: '12116'
abstract:
- lang: eng
text: Russia’s unprovoked attack on Ukraine has destroyed civilian infrastructure,
including universities, research centers, and other academic infrastructure (1).
Many Ukrainian scholars and researchers remain in Ukraine, and their work has
suffered from major setbacks (2–4). We call on international scientists and institutions
to support them.
article_processing_charge: No
article_type: letter_note
author:
- first_name: Karishma
full_name: Chhugani, Karishma
last_name: Chhugani
- first_name: Alina
full_name: Frolova, Alina
last_name: Frolova
- first_name: Yuriy
full_name: Salyha, Yuriy
last_name: Salyha
- first_name: Andrada
full_name: Fiscutean, Andrada
last_name: Fiscutean
- first_name: Oksana
full_name: Zlenko, Oksana
last_name: Zlenko
- first_name: Sanita
full_name: Reinsone, Sanita
last_name: Reinsone
- first_name: Walter W.
full_name: Wolfsberger, Walter W.
last_name: Wolfsberger
- first_name: Oleksandra V.
full_name: Ivashchenko, Oleksandra V.
last_name: Ivashchenko
- first_name: Megi
full_name: Maci, Megi
last_name: Maci
- first_name: Dmytro
full_name: Dziuba, Dmytro
last_name: Dziuba
- first_name: Andrii
full_name: Parkhomenko, Andrii
last_name: Parkhomenko
- first_name: Eric
full_name: Bortz, Eric
last_name: Bortz
- first_name: Fyodor
full_name: Kondrashov, Fyodor
id: 44FDEF62-F248-11E8-B48F-1D18A9856A87
last_name: Kondrashov
orcid: 0000-0001-8243-4694
- first_name: Paweł P.
full_name: Łabaj, Paweł P.
last_name: Łabaj
- first_name: Veronika
full_name: Romero, Veronika
last_name: Romero
- first_name: Jakub
full_name: Hlávka, Jakub
last_name: Hlávka
- first_name: Taras K.
full_name: Oleksyk, Taras K.
last_name: Oleksyk
- first_name: Serghei
full_name: Mangul, Serghei
last_name: Mangul
citation:
ama: Chhugani K, Frolova A, Salyha Y, et al. Remote opportunities for scholars in
Ukraine. Science. 2022;378(6626):1285-1286. doi:10.1126/science.adg0797
apa: Chhugani, K., Frolova, A., Salyha, Y., Fiscutean, A., Zlenko, O., Reinsone,
S., … Mangul, S. (2022). Remote opportunities for scholars in Ukraine. Science.
American Association for the Advancement of Science. https://doi.org/10.1126/science.adg0797
chicago: Chhugani, Karishma, Alina Frolova, Yuriy Salyha, Andrada Fiscutean, Oksana
Zlenko, Sanita Reinsone, Walter W. Wolfsberger, et al. “Remote Opportunities for
Scholars in Ukraine.” Science. American Association for the Advancement
of Science, 2022. https://doi.org/10.1126/science.adg0797.
ieee: K. Chhugani et al., “Remote opportunities for scholars in Ukraine,”
Science, vol. 378, no. 6626. American Association for the Advancement of
Science, pp. 1285–1286, 2022.
ista: Chhugani K, Frolova A, Salyha Y, Fiscutean A, Zlenko O, Reinsone S, Wolfsberger
WW, Ivashchenko OV, Maci M, Dziuba D, Parkhomenko A, Bortz E, Kondrashov F, Łabaj
PP, Romero V, Hlávka J, Oleksyk TK, Mangul S. 2022. Remote opportunities for scholars
in Ukraine. Science. 378(6626), 1285–1286.
mla: Chhugani, Karishma, et al. “Remote Opportunities for Scholars in Ukraine.”
Science, vol. 378, no. 6626, American Association for the Advancement of
Science, 2022, pp. 1285–86, doi:10.1126/science.adg0797.
short: K. Chhugani, A. Frolova, Y. Salyha, A. Fiscutean, O. Zlenko, S. Reinsone,
W.W. Wolfsberger, O.V. Ivashchenko, M. Maci, D. Dziuba, A. Parkhomenko, E. Bortz,
F. Kondrashov, P.P. Łabaj, V. Romero, J. Hlávka, T.K. Oleksyk, S. Mangul, Science
378 (2022) 1285–1286.
date_created: 2023-01-12T11:56:30Z
date_published: 2022-12-22T00:00:00Z
date_updated: 2023-10-03T11:01:06Z
day: '22'
department:
- _id: FyKo
doi: 10.1126/science.adg0797
external_id:
isi:
- '000963463700023'
intvolume: ' 378'
isi: 1
issue: '6626'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://doi.org/10.1126/science.adg0797
month: '12'
oa: 1
oa_version: Published Version
page: 1285-1286
publication: Science
publication_identifier:
eissn:
- 1095-9203
issn:
- 0036-8075
publication_status: published
publisher: American Association for the Advancement of Science
quality_controlled: '1'
scopus_import: '1'
status: public
title: Remote opportunities for scholars in Ukraine
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 378
year: '2022'
...
---
_id: '12117'
abstract:
- lang: eng
text: "To understand how potential gene manipulations affect in vitro microglia,
we provide a set of short protocols to evaluate microglia identity and function.
We detail steps for immunostaining to determine microglia identity. We describe
three functional assays for microglia: phagocytosis, calcium response following
ATP stimulation, and cytokine expression upon inflammatory stimuli. We apply these
protocols to human induced-pluripotent-stem-cell (hiPSC)-derived microglia, but
they can be also applied to other in vitro microglial models including primary
mouse microglia.\r\nFor complete details on the use and execution of this protocol,
please refer to Bartalska et al. (2022).1"
acknowledged_ssus:
- _id: Bio
acknowledgement: This project has received funding from the European Research Council
(ERC) under the European Union’s Horizon 2020 research and innovation program (grant
No. 715571 to S.S.) and from the Gesellschaft für Forschungsförderung Niederösterreich
(grant No. Sc19-017 to V.H.). We thank Rouven Schulz and Alessandro Venturino for
their insights into functional assays and data analysis, Verena Seiboth for insights
into necessary institutional permission, and ISTA imaging & optics facility (IOF)
especially Bernhard Hochreiter for their support.
article_number: '101866'
article_processing_charge: No
article_type: letter_note
author:
- first_name: Verena
full_name: Hübschmann, Verena
id: 32B7C918-F248-11E8-B48F-1D18A9856A87
last_name: Hübschmann
- first_name: Medina
full_name: Korkut, Medina
id: 4B51CE74-F248-11E8-B48F-1D18A9856A87
last_name: Korkut
orcid: 0000-0003-4309-2251
- first_name: Sandra
full_name: Siegert, Sandra
id: 36ACD32E-F248-11E8-B48F-1D18A9856A87
last_name: Siegert
orcid: 0000-0001-8635-0877
citation:
ama: Hübschmann V, Korkut M, Siegert S. Assessing human iPSC-derived microglia identity
and function by immunostaining, phagocytosis, calcium activity, and inflammation
assay. STAR Protocols. 2022;3(4). doi:10.1016/j.xpro.2022.101866
apa: Hübschmann, V., Korkut, M., & Siegert, S. (2022). Assessing human iPSC-derived
microglia identity and function by immunostaining, phagocytosis, calcium activity,
and inflammation assay. STAR Protocols. Elsevier. https://doi.org/10.1016/j.xpro.2022.101866
chicago: Hübschmann, Verena, Medina Korkut, and Sandra Siegert. “Assessing Human
IPSC-Derived Microglia Identity and Function by Immunostaining, Phagocytosis,
Calcium Activity, and Inflammation Assay.” STAR Protocols. Elsevier, 2022.
https://doi.org/10.1016/j.xpro.2022.101866.
ieee: V. Hübschmann, M. Korkut, and S. Siegert, “Assessing human iPSC-derived microglia
identity and function by immunostaining, phagocytosis, calcium activity, and inflammation
assay,” STAR Protocols, vol. 3, no. 4. Elsevier, 2022.
ista: Hübschmann V, Korkut M, Siegert S. 2022. Assessing human iPSC-derived microglia
identity and function by immunostaining, phagocytosis, calcium activity, and inflammation
assay. STAR Protocols. 3(4), 101866.
mla: Hübschmann, Verena, et al. “Assessing Human IPSC-Derived Microglia Identity
and Function by Immunostaining, Phagocytosis, Calcium Activity, and Inflammation
Assay.” STAR Protocols, vol. 3, no. 4, 101866, Elsevier, 2022, doi:10.1016/j.xpro.2022.101866.
short: V. Hübschmann, M. Korkut, S. Siegert, STAR Protocols 3 (2022).
date_created: 2023-01-12T11:56:38Z
date_published: 2022-12-16T00:00:00Z
date_updated: 2023-11-02T12:21:32Z
day: '16'
ddc:
- '570'
department:
- _id: SaSi
- _id: GradSch
doi: 10.1016/j.xpro.2022.101866
ec_funded: 1
file:
- access_level: open_access
checksum: 3c71b8a60633d42c2f77c49025d5559b
content_type: application/pdf
creator: dernst
date_created: 2023-01-23T09:50:51Z
date_updated: 2023-01-23T09:50:51Z
file_id: '12340'
file_name: 2022_STARProtocols_Huebschmann.pdf
file_size: 6251945
relation: main_file
success: 1
file_date_updated: 2023-01-23T09:50:51Z
has_accepted_license: '1'
intvolume: ' 3'
issue: '4'
keyword:
- General Immunology and Microbiology
- General Biochemistry
- Genetics and Molecular Biology
- General Neuroscience
language:
- iso: eng
month: '12'
oa: 1
oa_version: Published Version
project:
- _id: 25D4A630-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '715571'
name: Microglia action towards neuronal circuit formation and function in health
and disease
- _id: 9B99D380-BA93-11EA-9121-9846C619BF3A
grant_number: SC19-017
name: How human microglia shape developing neurons during health and inflammation
publication: STAR Protocols
publication_identifier:
issn:
- 2666-1667
publication_status: published
publisher: Elsevier
quality_controlled: '1'
related_material:
record:
- id: '11478'
relation: other
status: public
scopus_import: '1'
status: public
title: Assessing human iPSC-derived microglia identity and function by immunostaining,
phagocytosis, calcium activity, and inflammation assay
tmp:
image: /images/cc_by_nc_nd.png
legal_code_url: https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode
name: Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
(CC BY-NC-ND 4.0)
short: CC BY-NC-ND (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 3
year: '2022'
...
---
_id: '12118'
abstract:
- lang: eng
text: Hybrid semiconductor–superconductor devices hold great promise for realizing
topological quantum computing with Majorana zero modes1,2,3,4,5. However, multiple
claims of Majorana detection, based on either tunnelling6,7,8,9,10 or Coulomb
blockade (CB) spectroscopy11,12, remain disputed. Here we devise an experimental
protocol that allows us to perform both types of measurement on the same hybrid
island by adjusting its charging energy via tunable junctions to the normal leads.
This method reduces ambiguities of Majorana detections by checking the consistency
between CB spectroscopy and zero-bias peaks in non-blockaded transport. Specifically,
we observe junction-dependent, even–odd modulated, single-electron CB peaks in
InAs/Al hybrid nanowires without concomitant low-bias peaks in tunnelling spectroscopy.
We provide a theoretical interpretation of the experimental observations in terms
of low-energy, longitudinally confined island states rather than overlapping Majorana
modes. Our results highlight the importance of combined measurements on the same
device for the identification of topological Majorana zero modes.
acknowledged_ssus:
- _id: M-Shop
- _id: NanoFab
acknowledgement: We thank P. Krogstrup for providing us with the NW materials. We
thank A. Higginbotham, E. J. H. Lee, C. Marcus and S. Vaitiekėnas for helpful discussions
and G. Steffensen for his input on the diffusive Little-Parks theory. This research
was supported by the Scientific Service Units of ISTA through resources provided
by the MIBA Machine Shop and the nanofabrication facility; the NOMIS Foundation;
the CSIC Interdisciplinary Thematic Platform (PTI+) on Quantum Technologies (PTI-QTEP+).
A.H. acknowledges support from H2020-MSCA-IF-2018/844511. ICN2 also acknowledges
funding from Generalitat de Catalunya 2017 SGR 327. ICN2 is supported by the Severo
Ochoa Program from Spanish MINECO (Grant no. SEV-2017-0706) and is funded by the
CERCA Programme/Generalitat de Catalunya. Part of the present work has been performed
in the framework of Universitat Autònoma de Barcelona Materials Science PhD programme.
Authors acknowledge the use of instrumentation as well as the technical advice provided
by the National Facility ELECMI ICTS, node ‘Laboratorio de Microscopías Avanzadas’
at University of Zaragoza. This project has received funding from the European Union’s
Horizon 2020 research and innovation programme under grant agreement no. 823717-ESTEEM3.
This study was supported by MCIN with funding from European Union NextGenerationEU
(PRTR-C17.I1) and Generalitat de Catalunya. This research is part of the CSIC programme
for the Spanish Recovery, Transformation and Resilience Plan funded by the Recovery
and Resilience Facility of the European Union, established by the Regulation (EU)
2020/2094. We thank support from Grant PGC2018-097018-BI00, project FlagERA TOPOGRAPH
(PCI2018-093026) and project NANOGEN (PID2020-116093RB-C43), funded by MCIN/AEI/10.13039/501100011033/
and by ‘ERDF A way of making Europe’, by the European Union. M. Botifoll acknowledges
support from SUR Generalitat de Catalunya and the EU Social Fund (project ref. 2020
FI 00103).
article_processing_charge: No
article_type: original
arxiv: 1
author:
- first_name: Marco
full_name: Valentini, Marco
id: C0BB2FAC-D767-11E9-B658-BC13E6697425
last_name: Valentini
- first_name: Maksim
full_name: Borovkov, Maksim
id: 2ac7a0a2-3562-11eb-9256-fbd18ea55087
last_name: Borovkov
- first_name: Elsa
full_name: Prada, Elsa
last_name: Prada
- first_name: Sara
full_name: Martí-Sánchez, Sara
last_name: Martí-Sánchez
- first_name: Marc
full_name: Botifoll, Marc
last_name: Botifoll
- first_name: Andrea C
full_name: Hofmann, Andrea C
id: 340F461A-F248-11E8-B48F-1D18A9856A87
last_name: Hofmann
- first_name: Jordi
full_name: Arbiol, Jordi
last_name: Arbiol
- first_name: Ramón
full_name: Aguado, Ramón
last_name: Aguado
- first_name: Pablo
full_name: San-Jose, Pablo
last_name: San-Jose
- first_name: Georgios
full_name: Katsaros, Georgios
id: 38DB5788-F248-11E8-B48F-1D18A9856A87
last_name: Katsaros
orcid: 0000-0001-8342-202X
citation:
ama: Valentini M, Borovkov M, Prada E, et al. Majorana-like Coulomb spectroscopy
in the absence of zero-bias peaks. Nature. 2022;612(7940):442-447. doi:10.1038/s41586-022-05382-w
apa: Valentini, M., Borovkov, M., Prada, E., Martí-Sánchez, S., Botifoll, M., Hofmann,
A. C., … Katsaros, G. (2022). Majorana-like Coulomb spectroscopy in the absence
of zero-bias peaks. Nature. Springer Nature. https://doi.org/10.1038/s41586-022-05382-w
chicago: Valentini, Marco, Maksim Borovkov, Elsa Prada, Sara Martí-Sánchez, Marc
Botifoll, Andrea C Hofmann, Jordi Arbiol, Ramón Aguado, Pablo San-Jose, and Georgios
Katsaros. “Majorana-like Coulomb Spectroscopy in the Absence of Zero-Bias Peaks.”
Nature. Springer Nature, 2022. https://doi.org/10.1038/s41586-022-05382-w.
ieee: M. Valentini et al., “Majorana-like Coulomb spectroscopy in the absence
of zero-bias peaks,” Nature, vol. 612, no. 7940. Springer Nature, pp. 442–447,
2022.
ista: Valentini M, Borovkov M, Prada E, Martí-Sánchez S, Botifoll M, Hofmann AC,
Arbiol J, Aguado R, San-Jose P, Katsaros G. 2022. Majorana-like Coulomb spectroscopy
in the absence of zero-bias peaks. Nature. 612(7940), 442–447.
mla: Valentini, Marco, et al. “Majorana-like Coulomb Spectroscopy in the Absence
of Zero-Bias Peaks.” Nature, vol. 612, no. 7940, Springer Nature, 2022,
pp. 442–47, doi:10.1038/s41586-022-05382-w.
short: M. Valentini, M. Borovkov, E. Prada, S. Martí-Sánchez, M. Botifoll, A.C.
Hofmann, J. Arbiol, R. Aguado, P. San-Jose, G. Katsaros, Nature 612 (2022) 442–447.
date_created: 2023-01-12T11:56:45Z
date_published: 2022-12-15T00:00:00Z
date_updated: 2024-02-21T12:35:33Z
day: '15'
department:
- _id: GeKa
doi: 10.1038/s41586-022-05382-w
ec_funded: 1
external_id:
arxiv:
- '2203.07829'
isi:
- '000899725400001'
intvolume: ' 612'
isi: 1
issue: '7940'
keyword:
- Multidisciplinary
language:
- iso: eng
main_file_link:
- open_access: '1'
url: ' https://doi.org/10.48550/arXiv.2203.07829'
month: '12'
oa: 1
oa_version: Preprint
page: 442-447
project:
- _id: 26A151DA-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '844511'
name: Majorana bound states in Ge/SiGe heterostructures
publication: Nature
publication_identifier:
eissn:
- 1476-4687
issn:
- 0028-0836
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
related_material:
link:
- description: News on ISTA Website
relation: press_release
url: https://ista.ac.at/en/news/imposter-particles-revealed-and-explained/
record:
- id: '13286'
relation: dissertation_contains
status: public
- id: '12522'
relation: research_data
status: public
scopus_import: '1'
status: public
title: Majorana-like Coulomb spectroscopy in the absence of zero-bias peaks
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 612
year: '2022'
...
---
_id: '12119'
abstract:
- lang: eng
text: Intravascular neutrophils and platelets collaborate in maintaining host integrity,
but their interaction can also trigger thrombotic complications. We report here
that cooperation between neutrophil and platelet lineages extends to the earliest
stages of platelet formation by megakaryocytes in the bone marrow. Using intravital
microscopy, we show that neutrophils “plucked” intravascular megakaryocyte extensions,
termed proplatelets, to control platelet production. Following CXCR4-CXCL12-dependent
migration towards perisinusoidal megakaryocytes, plucking neutrophils actively
pulled on proplatelets and triggered myosin light chain and extracellular-signal-regulated
kinase activation through reactive oxygen species. By these mechanisms, neutrophils
accelerate proplatelet growth and facilitate continuous release of platelets in
steady state. Following myocardial infarction, plucking neutrophils drove excessive
release of young, reticulated platelets and boosted the risk of recurrent ischemia.
Ablation of neutrophil plucking normalized thrombopoiesis and reduced recurrent
thrombosis after myocardial infarction and thrombus burden in venous thrombosis.
We establish neutrophil plucking as a target to reduce thromboischemic events.
acknowledgement: "We thank Coung Kieu and Dominik van den Heuvel for excellent technical
assistance. This work was supported by the German Research Foundation (PE2704/2-1,
PE2704/3-1 to T.P., SFB 1123-project B06 to S.M., SFB1525 project A07 to D.S, TRR
332 project A7 to C.S., PO 2247/2-1 to A.P., SFB1116-project B11 to A.P. and B12
to M.K.), LMU Munich’s Institutional\r\nStrategy LMUexcellent within the framework
of the German Excellence Initiative (No. 806 32 006 to T.P.), and by the German
Centre for Cardiovascular Research (DZHK) to T.P. (Postdoc Start-up grant No. 100378833).
This project has received funding from the European Research Council (ERC) under
the European Union’s Horizon 2020 research and innovation program (grant agreement
No. 833440 to S.M.). F.G. received funding from the European Union’s\r\nHorizon
2020 research and innovation program under the Marie Sk1odowska-Curie grant agreement
no. 747687. A.H. was funded by RTI2018-095497-B-I00 from Ministerio de Ciencia e
Innovacio´ n (MICINN), HR17_00527 from Fundacion La Caixa, and Transatlantic Network
of Excellence (TNE-18CVD04) from the Leducq Foundation. The CNIC is supported by
the MICINN and the Pro CNIC Foundation and is a Severo Ochoa Center of Excellence
(CEX2020-001041-S). A.P. was supported by the Forschungskommission of the Medical
Faculty of the Heinrich-Heine-Universität Düsseldorf (No. 18-2019 to A.P.). C.G.
was supported by the Helmholtz Alliance ‘Aging and Metabolic Programming, AMPro,’
by the German Federal\r\nMinistry of Education and Research to the German Center
for Diabetes Research (DZD), and by the Bavarian State Ministry of Health and Care
through the research project DigiMed Bayern."
article_processing_charge: No
article_type: original
author:
- first_name: Tobias
full_name: Petzold, Tobias
last_name: Petzold
- first_name: Zhe
full_name: Zhang, Zhe
last_name: Zhang
- first_name: Iván
full_name: Ballesteros, Iván
last_name: Ballesteros
- first_name: Inas
full_name: Saleh, Inas
last_name: Saleh
- first_name: Amin
full_name: Polzin, Amin
last_name: Polzin
- first_name: Manuela
full_name: Thienel, Manuela
last_name: Thienel
- first_name: Lulu
full_name: Liu, Lulu
last_name: Liu
- first_name: Qurrat
full_name: Ul Ain, Qurrat
last_name: Ul Ain
- first_name: Vincent
full_name: Ehreiser, Vincent
last_name: Ehreiser
- first_name: Christian
full_name: Weber, Christian
last_name: Weber
- first_name: Badr
full_name: Kilani, Badr
last_name: Kilani
- first_name: Pontus
full_name: Mertsch, Pontus
last_name: Mertsch
- first_name: Jeremias
full_name: Götschke, Jeremias
last_name: Götschke
- first_name: Sophie
full_name: Cremer, Sophie
last_name: Cremer
- first_name: Wenwen
full_name: Fu, Wenwen
last_name: Fu
- first_name: Michael
full_name: Lorenz, Michael
last_name: Lorenz
- first_name: Hellen
full_name: Ishikawa-Ankerhold, Hellen
last_name: Ishikawa-Ankerhold
- first_name: Elisabeth
full_name: Raatz, Elisabeth
last_name: Raatz
- first_name: Shaza
full_name: El-Nemr, Shaza
last_name: El-Nemr
- first_name: Agnes
full_name: Görlach, Agnes
last_name: Görlach
- first_name: Esther
full_name: Marhuenda, Esther
last_name: Marhuenda
- first_name: Konstantin
full_name: Stark, Konstantin
last_name: Stark
- first_name: Joachim
full_name: Pircher, Joachim
last_name: Pircher
- first_name: David
full_name: Stegner, David
last_name: Stegner
- first_name: Christian
full_name: Gieger, Christian
last_name: Gieger
- first_name: Marc
full_name: Schmidt-Supprian, Marc
last_name: Schmidt-Supprian
- first_name: Florian R
full_name: Gärtner, Florian R
id: 397A88EE-F248-11E8-B48F-1D18A9856A87
last_name: Gärtner
orcid: 0000-0001-6120-3723
- first_name: Isaac
full_name: Almendros, Isaac
last_name: Almendros
- first_name: Malte
full_name: Kelm, Malte
last_name: Kelm
- first_name: Christian
full_name: Schulz, Christian
last_name: Schulz
- first_name: Andrés
full_name: Hidalgo, Andrés
last_name: Hidalgo
- first_name: Steffen
full_name: Massberg, Steffen
last_name: Massberg
citation:
ama: Petzold T, Zhang Z, Ballesteros I, et al. Neutrophil “plucking” on megakaryocytes
drives platelet production and boosts cardiovascular disease. Immunity.
2022;55(12):2285-2299.e7. doi:10.1016/j.immuni.2022.10.001
apa: Petzold, T., Zhang, Z., Ballesteros, I., Saleh, I., Polzin, A., Thienel, M.,
… Massberg, S. (2022). Neutrophil “plucking” on megakaryocytes drives platelet
production and boosts cardiovascular disease. Immunity. Elsevier. https://doi.org/10.1016/j.immuni.2022.10.001
chicago: Petzold, Tobias, Zhe Zhang, Iván Ballesteros, Inas Saleh, Amin Polzin,
Manuela Thienel, Lulu Liu, et al. “Neutrophil ‘Plucking’ on Megakaryocytes Drives
Platelet Production and Boosts Cardiovascular Disease.” Immunity. Elsevier,
2022. https://doi.org/10.1016/j.immuni.2022.10.001.
ieee: T. Petzold et al., “Neutrophil ‘plucking’ on megakaryocytes drives
platelet production and boosts cardiovascular disease,” Immunity, vol.
55, no. 12. Elsevier, p. 2285–2299.e7, 2022.
ista: Petzold T, Zhang Z, Ballesteros I, Saleh I, Polzin A, Thienel M, Liu L, Ul
Ain Q, Ehreiser V, Weber C, Kilani B, Mertsch P, Götschke J, Cremer S, Fu W, Lorenz
M, Ishikawa-Ankerhold H, Raatz E, El-Nemr S, Görlach A, Marhuenda E, Stark K,
Pircher J, Stegner D, Gieger C, Schmidt-Supprian M, Gärtner FR, Almendros I, Kelm
M, Schulz C, Hidalgo A, Massberg S. 2022. Neutrophil “plucking” on megakaryocytes
drives platelet production and boosts cardiovascular disease. Immunity. 55(12),
2285–2299.e7.
mla: Petzold, Tobias, et al. “Neutrophil ‘Plucking’ on Megakaryocytes Drives Platelet
Production and Boosts Cardiovascular Disease.” Immunity, vol. 55, no. 12,
Elsevier, 2022, p. 2285–2299.e7, doi:10.1016/j.immuni.2022.10.001.
short: T. Petzold, Z. Zhang, I. Ballesteros, I. Saleh, A. Polzin, M. Thienel, L.
Liu, Q. Ul Ain, V. Ehreiser, C. Weber, B. Kilani, P. Mertsch, J. Götschke, S.
Cremer, W. Fu, M. Lorenz, H. Ishikawa-Ankerhold, E. Raatz, S. El-Nemr, A. Görlach,
E. Marhuenda, K. Stark, J. Pircher, D. Stegner, C. Gieger, M. Schmidt-Supprian,
F.R. Gärtner, I. Almendros, M. Kelm, C. Schulz, A. Hidalgo, S. Massberg, Immunity
55 (2022) 2285–2299.e7.
date_created: 2023-01-12T11:56:54Z
date_published: 2022-12-13T00:00:00Z
date_updated: 2023-08-03T14:21:51Z
day: '13'
ddc:
- '570'
department:
- _id: MiSi
doi: 10.1016/j.immuni.2022.10.001
ec_funded: 1
external_id:
isi:
- '000922019600003'
pmid:
- '36272416'
file:
- access_level: open_access
checksum: 073267a9c0ad9f85a650053bc7b23777
content_type: application/pdf
creator: dernst
date_created: 2023-01-23T10:18:48Z
date_updated: 2023-01-23T10:18:48Z
file_id: '12341'
file_name: 2022_Immunity_Petzold.pdf
file_size: 5299475
relation: main_file
success: 1
file_date_updated: 2023-01-23T10:18:48Z
has_accepted_license: '1'
intvolume: ' 55'
isi: 1
issue: '12'
keyword:
- Infectious Diseases
- Immunology
- Immunology and Allergy
language:
- iso: eng
month: '12'
oa: 1
oa_version: Published Version
page: 2285-2299.e7
pmid: 1
project:
- _id: 260AA4E2-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '747687'
name: Mechanical Adaptation of Lamellipodial Actin Networks in Migrating Cells
publication: Immunity
publication_identifier:
issn:
- 1074-7613
publication_status: published
publisher: Elsevier
quality_controlled: '1'
scopus_import: '1'
status: public
title: Neutrophil “plucking” on megakaryocytes drives platelet production and boosts
cardiovascular disease
tmp:
image: /images/cc_by_nc_nd.png
legal_code_url: https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode
name: Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
(CC BY-NC-ND 4.0)
short: CC BY-NC-ND (4.0)
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 55
year: '2022'
...
---
_id: '12120'
abstract:
- lang: eng
text: Plant root architecture flexibly adapts to changing nitrate (NO3−) availability
in the soil; however, the underlying molecular mechanism of this adaptive development
remains under-studied. To explore the regulation of NO3−-mediated root growth,
we screened for low-nitrate-resistant mutant (lonr) and identified mutants that
were defective in the NAC transcription factor NAC075 (lonr1) as being less sensitive
to low NO3− in terms of primary root growth. We show that NAC075 is a mobile transcription
factor relocating from the root stele tissues to the endodermis based on NO3−
availability. Under low-NO3− availability, the kinase CBL-interacting protein
kinase 1 (CIPK1) is activated, and it phosphorylates NAC075, restricting its movement
from the stele, which leads to the transcriptional regulation of downstream target
WRKY53, consequently leading to adapted root architecture. Our work thus identifies
an adaptive mechanism involving translocation of transcription factor based on
nutrient availability and leading to cell-specific reprogramming of plant root
growth.
acknowledgement: The authors are grateful to Jörg Kudla, Ying Miao, Yu Zheng, Gang
Li, and Jun Zheng for providing published materials and to Wenkun Zhou and Caifu
Jiang for helpful discussions. This work was supported by grants from the National
Key Research and Development Program of China (2021YFF1000500), the National Natural
Science Foundation of China (32170265 and 32022007), the Beijing Municipal Natural
Science Foundation (5192011), and the Chinese Universities Scientific Fund (2022TC153).
article_processing_charge: No
article_type: original
author:
- first_name: Huixin
full_name: Xiao, Huixin
last_name: Xiao
- first_name: Yumei
full_name: Hu, Yumei
last_name: Hu
- first_name: Yaping
full_name: Wang, Yaping
last_name: Wang
- first_name: Jinkui
full_name: Cheng, Jinkui
last_name: Cheng
- first_name: Jinyi
full_name: Wang, Jinyi
last_name: Wang
- first_name: Guojingwei
full_name: Chen, Guojingwei
last_name: Chen
- first_name: Qian
full_name: Li, Qian
last_name: Li
- first_name: Shuwei
full_name: Wang, Shuwei
last_name: Wang
- first_name: Yalu
full_name: Wang, Yalu
last_name: Wang
- first_name: Shao-Shuai
full_name: Wang, Shao-Shuai
last_name: Wang
- first_name: Yi
full_name: Wang, Yi
last_name: Wang
- first_name: Wei
full_name: Xuan, Wei
last_name: Xuan
- first_name: Zhen
full_name: Li, Zhen
last_name: Li
- first_name: Yan
full_name: Guo, Yan
last_name: Guo
- first_name: Zhizhong
full_name: Gong, Zhizhong
last_name: Gong
- first_name: Jiří
full_name: Friml, Jiří
id: 4159519E-F248-11E8-B48F-1D18A9856A87
last_name: Friml
orcid: 0000-0002-8302-7596
- first_name: Jing
full_name: Zhang, Jing
last_name: Zhang
citation:
ama: Xiao H, Hu Y, Wang Y, et al. Nitrate availability controls translocation of
the transcription factor NAC075 for cell-type-specific reprogramming of root growth.
Developmental Cell. 2022;57(23):2638-2651.e6. doi:10.1016/j.devcel.2022.11.006
apa: Xiao, H., Hu, Y., Wang, Y., Cheng, J., Wang, J., Chen, G., … Zhang, J. (2022).
Nitrate availability controls translocation of the transcription factor NAC075
for cell-type-specific reprogramming of root growth. Developmental Cell.
Elsevier. https://doi.org/10.1016/j.devcel.2022.11.006
chicago: Xiao, Huixin, Yumei Hu, Yaping Wang, Jinkui Cheng, Jinyi Wang, Guojingwei
Chen, Qian Li, et al. “Nitrate Availability Controls Translocation of the Transcription
Factor NAC075 for Cell-Type-Specific Reprogramming of Root Growth.” Developmental
Cell. Elsevier, 2022. https://doi.org/10.1016/j.devcel.2022.11.006.
ieee: H. Xiao et al., “Nitrate availability controls translocation of the
transcription factor NAC075 for cell-type-specific reprogramming of root growth,”
Developmental Cell, vol. 57, no. 23. Elsevier, p. 2638–2651.e6, 2022.
ista: Xiao H, Hu Y, Wang Y, Cheng J, Wang J, Chen G, Li Q, Wang S, Wang Y, Wang
S-S, Wang Y, Xuan W, Li Z, Guo Y, Gong Z, Friml J, Zhang J. 2022. Nitrate availability
controls translocation of the transcription factor NAC075 for cell-type-specific
reprogramming of root growth. Developmental Cell. 57(23), 2638–2651.e6.
mla: Xiao, Huixin, et al. “Nitrate Availability Controls Translocation of the Transcription
Factor NAC075 for Cell-Type-Specific Reprogramming of Root Growth.” Developmental
Cell, vol. 57, no. 23, Elsevier, 2022, p. 2638–2651.e6, doi:10.1016/j.devcel.2022.11.006.
short: H. Xiao, Y. Hu, Y. Wang, J. Cheng, J. Wang, G. Chen, Q. Li, S. Wang, Y. Wang,
S.-S. Wang, Y. Wang, W. Xuan, Z. Li, Y. Guo, Z. Gong, J. Friml, J. Zhang, Developmental
Cell 57 (2022) 2638–2651.e6.
date_created: 2023-01-12T11:57:00Z
date_published: 2022-12-05T00:00:00Z
date_updated: 2023-10-04T08:23:20Z
day: '05'
department:
- _id: JiFr
doi: 10.1016/j.devcel.2022.11.006
external_id:
isi:
- '000919603800005'
pmid:
- '36473460'
intvolume: ' 57'
isi: 1
issue: '23'
keyword:
- Developmental Biology
- Cell Biology
- General Biochemistry
- Genetics and Molecular Biology
- Molecular Biology
language:
- iso: eng
month: '12'
oa_version: None
page: 2638-2651.e6
pmid: 1
publication: Developmental Cell
publication_identifier:
issn:
- 1534-5807
publication_status: published
publisher: Elsevier
quality_controlled: '1'
scopus_import: '1'
status: public
title: Nitrate availability controls translocation of the transcription factor NAC075
for cell-type-specific reprogramming of root growth
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 57
year: '2022'
...
---
_id: '12121'
abstract:
- lang: eng
text: Autophagosomes are double-membraned vesicles that traffic harmful or unwanted
cellular macromolecules to the vacuole for recycling. Although autophagosome biogenesis
has been extensively studied, autophagosome maturation, i.e., delivery and fusion
with the vacuole, remains largely unknown in plants. Here, we have identified
an autophagy adaptor, CFS1, that directly interacts with the autophagosome marker
ATG8 and localizes on both membranes of the autophagosome. Autophagosomes form
normally in Arabidopsis thaliana cfs1 mutants, but their delivery to the vacuole
is disrupted. CFS1’s function is evolutionarily conserved in plants, as it also
localizes to the autophagosomes and plays a role in autophagic flux in the liverwort
Marchantia polymorpha. CFS1 regulates autophagic flux by bridging autophagosomes
with the multivesicular body-localized ESCRT-I component VPS23A, leading to the
formation of amphisomes. Similar to CFS1-ATG8 interaction, disrupting the CFS1-VPS23A
interaction blocks autophagic flux and renders plants sensitive to nitrogen starvation.
Altogether, our results reveal a conserved vacuolar sorting hub that regulates
autophagic flux in plants.
acknowledgement: "We thank Suayip Ustün, Karin Schumacher, Erika Isono, Gerd Juergens,
Takashi Ueda, Daniel Hofius, and Liwen Jiang for sharing published materials.\r\nWe
acknowledge funding from Austrian Academy of Sciences, Austrian Science Fund (FWF,
P 32355, P 34944), Austrian Science Fund (FWF-SFB F79), Vienna Science and Technology\r\nFund
(WWTF, LS17-047) to Y. Dagdas; Austrian Academy of Sciences DOC Fellowship to J.
Zhao, Marie Curie VIP2 Fellowship to J.C. De La Concepcion and M. Clavel; Hong Kong
Research Grant Council (GRF14121019, 14113921, AoE/M-05/12, C4002-17G) to B.-H.
Kang. We thank Vienna Biocenter Core Facilities (VBCF) Protein Chemistry, Biooptics,
Plant Sciences, Molecular Biology, and Protein Technologies. We thank J. Matthew
Watson\r\nand members of the Dagdas lab for the critical reading and editing of
the manuscript."
article_number: e202203139
article_processing_charge: No
article_type: original
author:
- first_name: Jierui
full_name: Zhao, Jierui
last_name: Zhao
- first_name: Mai Thu
full_name: Bui, Mai Thu
last_name: Bui
- first_name: Juncai
full_name: Ma, Juncai
last_name: Ma
- first_name: Fabian
full_name: Künzl, Fabian
last_name: Künzl
- first_name: Lorenzo
full_name: Picchianti, Lorenzo
last_name: Picchianti
- first_name: Juan Carlos
full_name: De La Concepcion, Juan Carlos
last_name: De La Concepcion
- first_name: Yixuan
full_name: Chen, Yixuan
last_name: Chen
- first_name: Sofia
full_name: Petsangouraki, Sofia
last_name: Petsangouraki
- first_name: Azadeh
full_name: Mohseni, Azadeh
last_name: Mohseni
- first_name: Marta
full_name: García-Leon, Marta
last_name: García-Leon
- first_name: Marta Salas
full_name: Gomez, Marta Salas
last_name: Gomez
- first_name: Caterina
full_name: Giannini, Caterina
id: e3fdddd5-f6e0-11ea-865d-ca99ee6367f4
last_name: Giannini
- first_name: Dubois
full_name: Gwennogan, Dubois
last_name: Gwennogan
- first_name: Roksolana
full_name: Kobylinska, Roksolana
last_name: Kobylinska
- first_name: Marion
full_name: Clavel, Marion
last_name: Clavel
- first_name: Swen
full_name: Schellmann, Swen
last_name: Schellmann
- first_name: Yvon
full_name: Jaillais, Yvon
last_name: Jaillais
- first_name: Jiří
full_name: Friml, Jiří
id: 4159519E-F248-11E8-B48F-1D18A9856A87
last_name: Friml
orcid: 0000-0002-8302-7596
- first_name: Byung-Ho
full_name: Kang, Byung-Ho
last_name: Kang
- first_name: Yasin
full_name: Dagdas, Yasin
last_name: Dagdas
citation:
ama: Zhao J, Bui MT, Ma J, et al. Plant autophagosomes mature into amphisomes prior
to their delivery to the central vacuole. Journal of Cell Biology. 2022;221(12).
doi:10.1083/jcb.202203139
apa: Zhao, J., Bui, M. T., Ma, J., Künzl, F., Picchianti, L., De La Concepcion,
J. C., … Dagdas, Y. (2022). Plant autophagosomes mature into amphisomes prior
to their delivery to the central vacuole. Journal of Cell Biology. Rockefeller
University Press. https://doi.org/10.1083/jcb.202203139
chicago: Zhao, Jierui, Mai Thu Bui, Juncai Ma, Fabian Künzl, Lorenzo Picchianti,
Juan Carlos De La Concepcion, Yixuan Chen, et al. “Plant Autophagosomes Mature
into Amphisomes Prior to Their Delivery to the Central Vacuole.” Journal of
Cell Biology. Rockefeller University Press, 2022. https://doi.org/10.1083/jcb.202203139.
ieee: J. Zhao et al., “Plant autophagosomes mature into amphisomes prior
to their delivery to the central vacuole,” Journal of Cell Biology, vol.
221, no. 12. Rockefeller University Press, 2022.
ista: Zhao J, Bui MT, Ma J, Künzl F, Picchianti L, De La Concepcion JC, Chen Y,
Petsangouraki S, Mohseni A, García-Leon M, Gomez MS, Giannini C, Gwennogan D,
Kobylinska R, Clavel M, Schellmann S, Jaillais Y, Friml J, Kang B-H, Dagdas Y.
2022. Plant autophagosomes mature into amphisomes prior to their delivery to the
central vacuole. Journal of Cell Biology. 221(12), e202203139.
mla: Zhao, Jierui, et al. “Plant Autophagosomes Mature into Amphisomes Prior to
Their Delivery to the Central Vacuole.” Journal of Cell Biology, vol. 221,
no. 12, e202203139, Rockefeller University Press, 2022, doi:10.1083/jcb.202203139.
short: J. Zhao, M.T. Bui, J. Ma, F. Künzl, L. Picchianti, J.C. De La Concepcion,
Y. Chen, S. Petsangouraki, A. Mohseni, M. García-Leon, M.S. Gomez, C. Giannini,
D. Gwennogan, R. Kobylinska, M. Clavel, S. Schellmann, Y. Jaillais, J. Friml,
B.-H. Kang, Y. Dagdas, Journal of Cell Biology 221 (2022).
date_created: 2023-01-12T11:57:10Z
date_published: 2022-12-01T00:00:00Z
date_updated: 2023-08-03T14:20:15Z
day: '01'
ddc:
- '580'
department:
- _id: JiFr
doi: 10.1083/jcb.202203139
external_id:
isi:
- '000932958800001'
pmid:
- '36260289'
file:
- access_level: open_access
checksum: 050b5cc4b25e6b94fe3e3cbfe0f5c06b
content_type: application/pdf
creator: dernst
date_created: 2023-01-23T10:30:11Z
date_updated: 2023-01-23T10:30:11Z
file_id: '12342'
file_name: 2022_JCB_Zhao.pdf
file_size: 10365777
relation: main_file
success: 1
file_date_updated: 2023-01-23T10:30:11Z
has_accepted_license: '1'
intvolume: ' 221'
isi: 1
issue: '12'
keyword:
- Cell Biology
language:
- iso: eng
month: '12'
oa: 1
oa_version: Published Version
pmid: 1
publication: Journal of Cell Biology
publication_identifier:
eissn:
- 1540-8140
issn:
- 0021-9525
publication_status: published
publisher: Rockefeller University Press
quality_controlled: '1'
scopus_import: '1'
status: public
title: Plant autophagosomes mature into amphisomes prior to their delivery to the
central vacuole
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 221
year: '2022'
...
---
_id: '12122'
abstract:
- lang: eng
text: Centrosomes play a crucial role during immune cell interactions and initiation
of the immune response. In proliferating cells, centrosome numbers are tightly
controlled and generally limited to one in G1 and two prior to mitosis. Defects
in regulating centrosome numbers have been associated with cell transformation
and tumorigenesis. Here, we report the emergence of extra centrosomes in leukocytes
during immune activation. Upon antigen encounter, dendritic cells pass through
incomplete mitosis and arrest in the subsequent G1 phase leading to tetraploid
cells with accumulated centrosomes. In addition, cell stimulation increases expression
of polo-like kinase 2, resulting in diploid cells with two centrosomes in G1-arrested
cells. During cell migration, centrosomes tightly cluster and act as functional
microtubule-organizing centers allowing for increased persistent locomotion along
gradients of chemotactic cues. Moreover, dendritic cells with extra centrosomes
display enhanced secretion of inflammatory cytokines and optimized T cell responses.
Together, these results demonstrate a previously unappreciated role of extra centrosomes
for regular cell and tissue homeostasis.
acknowledgement: "We thank Markéta Dalecká and Irena Krejzová for their support with
FIB-SEM imaging, the Imaging Methods Core Facility at BIOCEV supported by the Ministry
of Education, Youth and Sports Czech Republic (Large RI Project LM2018129 Czech-BioImaging),
and European Regional Development Fund (project No. CZ.02.1.01/0.0/0.0/18_046/0016045)
for their support with obtaining imaging data presented in this paper. The authors
further thank Andreas Villunger, Florian Gärtner, Frank Bradke, and Sarah Förster
for helpful discussions; Andy Zielinski for help with statistics; and Björn Weiershausen
for assisting with figure illustration.\r\n\r\nThis work was funded by a fellowship
of the Ministry of Innovation, Science and Research of North-Rhine-Westphalia (AZ:
421-8.03.03.02-137069) to E. Kiermaier and the Deutsche Forschungsgemeinschaft (German
Research Foundation) under Germany’s Excellence Strategy – EXC 2151 – 390873048.
R. Hauschild was funded by grant number 2020-225401 from the Chan Zuckerberg Initiative
Donor-Advised Fund, an advised fund of Silicon Valley Community Foundation. M. Hons
is supported by Czech Science Foundation GACR 20-24603Y and Charles University PRIMUS/20/MED/013."
article_number: e202107134
article_processing_charge: No
article_type: original
author:
- first_name: Ann-Kathrin
full_name: Weier, Ann-Kathrin
last_name: Weier
- first_name: Mirka
full_name: Homrich, Mirka
last_name: Homrich
- first_name: Stephanie
full_name: Ebbinghaus, Stephanie
last_name: Ebbinghaus
- first_name: Pavel
full_name: Juda, Pavel
last_name: Juda
- first_name: Eliška
full_name: Miková, Eliška
last_name: Miková
- first_name: Robert
full_name: Hauschild, Robert
id: 4E01D6B4-F248-11E8-B48F-1D18A9856A87
last_name: Hauschild
orcid: 0000-0001-9843-3522
- first_name: Lili
full_name: Zhang, Lili
last_name: Zhang
- first_name: Thomas
full_name: Quast, Thomas
last_name: Quast
- first_name: Elvira
full_name: Mass, Elvira
last_name: Mass
- first_name: Andreas
full_name: Schlitzer, Andreas
last_name: Schlitzer
- first_name: Waldemar
full_name: Kolanus, Waldemar
last_name: Kolanus
- first_name: Sven
full_name: Burgdorf, Sven
last_name: Burgdorf
- first_name: Oliver J.
full_name: Gruß, Oliver J.
last_name: Gruß
- first_name: Miroslav
full_name: Hons, Miroslav
last_name: Hons
- first_name: Stefan
full_name: Wieser, Stefan
last_name: Wieser
- first_name: Eva
full_name: Kiermaier, Eva
last_name: Kiermaier
citation:
ama: Weier A-K, Homrich M, Ebbinghaus S, et al. Multiple centrosomes enhance migration
and immune cell effector functions of mature dendritic cells. Journal of Cell
Biology. 2022;221(12). doi:10.1083/jcb.202107134
apa: Weier, A.-K., Homrich, M., Ebbinghaus, S., Juda, P., Miková, E., Hauschild,
R., … Kiermaier, E. (2022). Multiple centrosomes enhance migration and immune
cell effector functions of mature dendritic cells. Journal of Cell Biology.
Rockefeller University Press. https://doi.org/10.1083/jcb.202107134
chicago: Weier, Ann-Kathrin, Mirka Homrich, Stephanie Ebbinghaus, Pavel Juda, Eliška
Miková, Robert Hauschild, Lili Zhang, et al. “Multiple Centrosomes Enhance Migration
and Immune Cell Effector Functions of Mature Dendritic Cells.” Journal of Cell
Biology. Rockefeller University Press, 2022. https://doi.org/10.1083/jcb.202107134.
ieee: A.-K. Weier et al., “Multiple centrosomes enhance migration and immune
cell effector functions of mature dendritic cells,” Journal of Cell Biology,
vol. 221, no. 12. Rockefeller University Press, 2022.
ista: Weier A-K, Homrich M, Ebbinghaus S, Juda P, Miková E, Hauschild R, Zhang L,
Quast T, Mass E, Schlitzer A, Kolanus W, Burgdorf S, Gruß OJ, Hons M, Wieser S,
Kiermaier E. 2022. Multiple centrosomes enhance migration and immune cell effector
functions of mature dendritic cells. Journal of Cell Biology. 221(12), e202107134.
mla: Weier, Ann-Kathrin, et al. “Multiple Centrosomes Enhance Migration and Immune
Cell Effector Functions of Mature Dendritic Cells.” Journal of Cell Biology,
vol. 221, no. 12, e202107134, Rockefeller University Press, 2022, doi:10.1083/jcb.202107134.
short: A.-K. Weier, M. Homrich, S. Ebbinghaus, P. Juda, E. Miková, R. Hauschild,
L. Zhang, T. Quast, E. Mass, A. Schlitzer, W. Kolanus, S. Burgdorf, O.J. Gruß,
M. Hons, S. Wieser, E. Kiermaier, Journal of Cell Biology 221 (2022).
date_created: 2023-01-12T12:01:09Z
date_published: 2022-12-05T00:00:00Z
date_updated: 2023-08-16T11:29:12Z
day: '05'
ddc:
- '570'
department:
- _id: Bio
doi: 10.1083/jcb.202107134
external_id:
isi:
- '000932941400001'
pmid:
- '36214847 '
file:
- access_level: open_access
checksum: 0c9af38f82af30c6ce528f2caece4246
content_type: application/pdf
creator: dernst
date_created: 2023-08-16T11:24:53Z
date_updated: 2023-08-16T11:24:53Z
file_id: '14065'
file_name: 2023_JCB_Weier.pdf
file_size: 11090179
relation: main_file
success: 1
file_date_updated: 2023-08-16T11:24:53Z
has_accepted_license: '1'
intvolume: ' 221'
isi: 1
issue: '12'
keyword:
- Cell Biology
language:
- iso: eng
month: '12'
oa: 1
oa_version: Published Version
pmid: 1
project:
- _id: c08e9ad1-5a5b-11eb-8a69-9d1cf3b07473
grant_number: CZI01
name: Tools for automation and feedback microscopy
publication: Journal of Cell Biology
publication_identifier:
eissn:
- 1540-8140
issn:
- 0021-9525
publication_status: published
publisher: Rockefeller University Press
quality_controlled: '1'
scopus_import: '1'
status: public
title: Multiple centrosomes enhance migration and immune cell effector functions of
mature dendritic cells
tmp:
image: /images/cc_by_nc_sa.png
legal_code_url: https://creativecommons.org/licenses/by-nc-sa/4.0/legalcode
name: Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC
BY-NC-SA 4.0)
short: CC BY-NC-SA (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 221
year: '2022'
...
---
_id: '12128'
abstract:
- lang: eng
text: We introduce a machine-learning (ML) framework for high-throughput benchmarking
of diverse representations of chemical systems against datasets of materials and
molecules. The guiding principle underlying the benchmarking approach is to evaluate
raw descriptor performance by limiting model complexity to simple regression schemes
while enforcing best ML practices, allowing for unbiased hyperparameter optimization,
and assessing learning progress through learning curves along series of synchronized
train-test splits. The resulting models are intended as baselines that can inform
future method development, in addition to indicating how easily a given dataset
can be learnt. Through a comparative analysis of the training outcome across a
diverse set of physicochemical, topological and geometric representations, we
glean insight into the relative merits of these representations as well as their
interrelatedness.
acknowledgement: 'C P acknowledges funding from Astex through the Sustaining Innovation
Program under the Milner Consortium. B C acknowledges resources provided by the
Cambridge Tier-2 system operated by the University of Cambridge Research Computing
Service funded by EPSRC Tier-2 capital Grant EP/P020259/1. F A F acknowledges funding
from the Swiss National Science Foundation (Grant No. P2BSP2_191736). '
article_number: '040501'
article_processing_charge: No
article_type: original
author:
- first_name: Carl
full_name: Poelking, Carl
last_name: Poelking
- first_name: Felix A
full_name: Faber, Felix A
last_name: Faber
- first_name: Bingqing
full_name: Cheng, Bingqing
id: cbe3cda4-d82c-11eb-8dc7-8ff94289fcc9
last_name: Cheng
orcid: 0000-0002-3584-9632
citation:
ama: 'Poelking C, Faber FA, Cheng B. BenchML: An extensible pipelining framework
for benchmarking representations of materials and molecules at scale. Machine
Learning: Science and Technology. 2022;3(4). doi:10.1088/2632-2153/ac4d11'
apa: 'Poelking, C., Faber, F. A., & Cheng, B. (2022). BenchML: An extensible
pipelining framework for benchmarking representations of materials and molecules
at scale. Machine Learning: Science and Technology. IOP Publishing. https://doi.org/10.1088/2632-2153/ac4d11'
chicago: 'Poelking, Carl, Felix A Faber, and Bingqing Cheng. “BenchML: An Extensible
Pipelining Framework for Benchmarking Representations of Materials and Molecules
at Scale.” Machine Learning: Science and Technology. IOP Publishing, 2022.
https://doi.org/10.1088/2632-2153/ac4d11.'
ieee: 'C. Poelking, F. A. Faber, and B. Cheng, “BenchML: An extensible pipelining
framework for benchmarking representations of materials and molecules at scale,”
Machine Learning: Science and Technology, vol. 3, no. 4. IOP Publishing,
2022.'
ista: 'Poelking C, Faber FA, Cheng B. 2022. BenchML: An extensible pipelining framework
for benchmarking representations of materials and molecules at scale. Machine
Learning: Science and Technology. 3(4), 040501.'
mla: 'Poelking, Carl, et al. “BenchML: An Extensible Pipelining Framework for Benchmarking
Representations of Materials and Molecules at Scale.” Machine Learning: Science
and Technology, vol. 3, no. 4, 040501, IOP Publishing, 2022, doi:10.1088/2632-2153/ac4d11.'
short: 'C. Poelking, F.A. Faber, B. Cheng, Machine Learning: Science and Technology
3 (2022).'
date_created: 2023-01-12T12:02:21Z
date_published: 2022-11-17T00:00:00Z
date_updated: 2023-08-04T08:49:53Z
day: '17'
ddc:
- '000'
department:
- _id: BiCh
doi: 10.1088/2632-2153/ac4d11
external_id:
isi:
- '000886534000001'
file:
- access_level: open_access
checksum: 8930d4ad6ed9b47358c6f1a68666adb6
content_type: application/pdf
creator: dernst
date_created: 2023-01-23T10:42:04Z
date_updated: 2023-01-23T10:42:04Z
file_id: '12343'
file_name: 2022_MachLearning_Poelking.pdf
file_size: 13814559
relation: main_file
success: 1
file_date_updated: 2023-01-23T10:42:04Z
has_accepted_license: '1'
intvolume: ' 3'
isi: 1
issue: '4'
keyword:
- Artificial Intelligence
- Human-Computer Interaction
- Software
language:
- iso: eng
month: '11'
oa: 1
oa_version: Published Version
publication: 'Machine Learning: Science and Technology'
publication_identifier:
issn:
- 2632-2153
publication_status: published
publisher: IOP Publishing
quality_controlled: '1'
related_material:
link:
- relation: software
url: https://github.com/capoe/benchml
scopus_import: '1'
status: public
title: 'BenchML: An extensible pipelining framework for benchmarking representations
of materials and molecules at scale'
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 3
year: '2022'
...
---
_id: '12129'
abstract:
- lang: eng
text: 'Given a finite point set P in general position in the plane, a full triangulation
of P is a maximal straight-line embedded plane graph on P. A partial triangulation
of P is a full triangulation of some subset P′ of P containing all extreme points
in P. A bistellar flip on a partial triangulation either flips an edge (called
edge flip), removes a non-extreme point of degree 3, or adds a point in P∖P′ as
vertex of degree 3. The bistellar flip graph has all partial triangulations as
vertices, and a pair of partial triangulations is adjacent if they can be obtained
from one another by a bistellar flip. The edge flip graph is defined with full
triangulations as vertices, and edge flips determining the adjacencies. Lawson
showed in the early seventies that these graphs are connected. The goal of this
paper is to investigate the structure of these graphs, with emphasis on their
vertex connectivity. For sets P of n points in the plane in general position,
we show that the edge flip graph is ⌈n/2−2⌉-vertex connected, and the bistellar
flip graph is (n−3)-vertex connected; both results are tight. The latter bound
matches the situation for the subfamily of regular triangulations (i.e., partial
triangulations obtained by lifting the points to 3-space and projecting back the
lower convex hull), where (n−3)-vertex connectivity has been known since the late
eighties through the secondary polytope due to Gelfand, Kapranov, & Zelevinsky
and Balinski’s Theorem. For the edge flip-graph, we additionally show that the
vertex connectivity is at least as large as (and hence equal to) the minimum degree
(i.e., the minimum number of flippable edges in any full triangulation), provided
that n is large enough. Our methods also yield several other results: (i) The
edge flip graph can be covered by graphs of polytopes of dimension ⌈n/2−2⌉ (products
of associahedra) and the bistellar flip graph can be covered by graphs of polytopes
of dimension n−3 (products of secondary polytopes). (ii) A partial triangulation
is regular, if it has distance n−3 in the Hasse diagram of the partial order of
partial subdivisions from the trivial subdivision. (iii) All partial triangulations
of a point set are regular iff the partial order of partial subdivisions has height
n−3. (iv) There are arbitrarily large sets P with non-regular partial triangulations
and such that every proper subset has only regular triangulations, i.e., there
are no small certificates for the existence of non-regular triangulations.'
acknowledgement: "This is a full and revised version of [38] (on partial triangulations)
in Proceedings of the 36th Annual International Symposium on Computational Geometry
(SoCG‘20) and of some of the results in [37] (on full triangulations) in Proceedings
of the 31st Annual ACM-SIAM Symposium on Discrete Algorithms (SODA‘20).\r\nThis
research started at the 11th Gremo’s Workshop on Open Problems (GWOP), Alp Sellamatt,
Switzerland, June 24–28, 2013, motivated by a question posed by Filip Mori´c on
full triangulations. Research was supported by the Swiss National Science Foundation
within the collaborative DACH project Arrangements and Drawings as SNSF Project
200021E-171681, and by IST Austria and Berlin Free University during a sabbatical
stay of the second author. We thank Michael Joswig, Jesús De Loera, and Francisco
Santos for helpful discussions on the topics of this paper, and Daniel Bertschinger
and Valentin Stoppiello for carefully reading earlier versions and for many helpful
comments.\r\nOpen access funding provided by the Swiss Federal Institute of Technology
Zürich"
article_processing_charge: No
article_type: original
author:
- first_name: Uli
full_name: Wagner, Uli
id: 36690CA2-F248-11E8-B48F-1D18A9856A87
last_name: Wagner
orcid: 0000-0002-1494-0568
- first_name: Emo
full_name: Welzl, Emo
last_name: Welzl
citation:
ama: Wagner U, Welzl E. Connectivity of triangulation flip graphs in the plane.
Discrete & Computational Geometry. 2022;68(4):1227-1284. doi:10.1007/s00454-022-00436-2
apa: Wagner, U., & Welzl, E. (2022). Connectivity of triangulation flip graphs
in the plane. Discrete & Computational Geometry. Springer Nature. https://doi.org/10.1007/s00454-022-00436-2
chicago: Wagner, Uli, and Emo Welzl. “Connectivity of Triangulation Flip Graphs
in the Plane.” Discrete & Computational Geometry. Springer Nature,
2022. https://doi.org/10.1007/s00454-022-00436-2.
ieee: U. Wagner and E. Welzl, “Connectivity of triangulation flip graphs in the
plane,” Discrete & Computational Geometry, vol. 68, no. 4. Springer
Nature, pp. 1227–1284, 2022.
ista: Wagner U, Welzl E. 2022. Connectivity of triangulation flip graphs in the
plane. Discrete & Computational Geometry. 68(4), 1227–1284.
mla: Wagner, Uli, and Emo Welzl. “Connectivity of Triangulation Flip Graphs in the
Plane.” Discrete & Computational Geometry, vol. 68, no. 4, Springer
Nature, 2022, pp. 1227–84, doi:10.1007/s00454-022-00436-2.
short: U. Wagner, E. Welzl, Discrete & Computational Geometry 68 (2022) 1227–1284.
date_created: 2023-01-12T12:02:28Z
date_published: 2022-11-14T00:00:00Z
date_updated: 2023-08-04T08:51:08Z
day: '14'
ddc:
- '510'
department:
- _id: UlWa
doi: 10.1007/s00454-022-00436-2
external_id:
isi:
- '000883222200003'
file:
- access_level: open_access
checksum: 307e879d09e52eddf5b225d0aaa9213a
content_type: application/pdf
creator: dernst
date_created: 2023-01-23T11:10:03Z
date_updated: 2023-01-23T11:10:03Z
file_id: '12345'
file_name: 2022_DiscreteCompGeometry_Wagner.pdf
file_size: 1747581
relation: main_file
success: 1
file_date_updated: 2023-01-23T11:10:03Z
has_accepted_license: '1'
intvolume: ' 68'
isi: 1
issue: '4'
keyword:
- Computational Theory and Mathematics
- Discrete Mathematics and Combinatorics
- Geometry and Topology
- Theoretical Computer Science
language:
- iso: eng
month: '11'
oa: 1
oa_version: Published Version
page: 1227-1284
publication: Discrete & Computational Geometry
publication_identifier:
eissn:
- 1432-0444
issn:
- 0179-5376
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
related_material:
record:
- id: '7807'
relation: earlier_version
status: public
- id: '7990'
relation: earlier_version
status: public
scopus_import: '1'
status: public
title: Connectivity of triangulation flip graphs in the plane
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 68
year: '2022'
...
---
_id: '12130'
abstract:
- lang: eng
text: Germline determination is essential for species survival and evolution in
multicellular organisms. In most flowering plants, formation of the female germline
is initiated with specification of one megaspore mother cell (MMC) in each ovule;
however, the molecular mechanism underlying this key event remains unclear. Here
we report that spatially restricted auxin signaling promotes MMC fate in Arabidopsis.
Our results show that the microRNA160 (miR160) targeted gene ARF17 (AUXIN RESPONSE
FACTOR17) is required for promoting MMC specification by genetically interacting
with the SPL/NZZ (SPOROCYTELESS/NOZZLE) gene. Alterations of auxin signaling cause
formation of supernumerary MMCs in an ARF17- and SPL/NZZ-dependent manner. Furthermore,
miR160 and ARF17 are indispensable for attaining a normal auxin maximum at the
ovule apex via modulating the expression domain of PIN1 (PIN-FORMED1) auxin transporter.
Our findings elucidate the mechanism by which auxin signaling promotes the acquisition
of female germline cell fate in plants.
acknowledgement: "We thank A. Cheung,W. Lukowitz, V.Walbot, D.Weijers, and R. Yadegari
for critically reading the manuscript; E. Xiong and G. Zhang for preparing some
experiments, T. Schuck, J. Gonnering, and P. Engevold for plant care, the Arabidopsis
Biological Resource Center (ABRC) for ARF10,ARF16, ARF17, EMS1,MIR160a BAC clones
and cDNAs, the SALK_090804 seed, T. Nakagawa for pGBW vectors, Y. Zhao for the YUC1
cDNA, Q. Chen for the pHEE401E vector, R. Yadegari for pAT5G01860::n1GFP, pAT5G45980:n1GFP,
pAT5G50490::n1GFP, pAT5G56200:n1GFP vectors, and D.Weijers for the pGreenII KAN
SV40-3×GFP and R2D2 vectors, W. Yang for the splmutant, Y. Qin for the pKNU::KNU-VENUS
vector and seed, G. Tang for the STTM160/160-48 vector, and L. Colombo for pPIN1::PIN1-GFP
spl and pin1-5 seeds. This work was supported by the US National Science Foundation
(NSF)-Israel Binational Science Foundation (BSF) research grant to D.Z. (IOS-1322796)
and T.A. (2012756). D.Z. also\r\ngratefully acknowledges supports of the Shaw Scientist
Award from the Greater Milwaukee Foundation, USDA National Institute of Food and
Agriculture (NIFA, 2022-67013-36294), the UWM Discovery and Innovation Grant, the
Bradley Catalyst Award from the UWM Research\r\nFoundation, and WiSys and UW System
Applied Research Funding Programs."
article_number: '6960'
article_processing_charge: No
article_type: original
author:
- first_name: Jian
full_name: Huang, Jian
last_name: Huang
- first_name: Lei
full_name: Zhao, Lei
last_name: Zhao
- first_name: Shikha
full_name: Malik, Shikha
last_name: Malik
- first_name: Benjamin R.
full_name: Gentile, Benjamin R.
last_name: Gentile
- first_name: Va
full_name: Xiong, Va
last_name: Xiong
- first_name: Tzahi
full_name: Arazi, Tzahi
last_name: Arazi
- first_name: Heather A.
full_name: Owen, Heather A.
last_name: Owen
- first_name: Jiří
full_name: Friml, Jiří
id: 4159519E-F248-11E8-B48F-1D18A9856A87
last_name: Friml
orcid: 0000-0002-8302-7596
- first_name: Dazhong
full_name: Zhao, Dazhong
last_name: Zhao
citation:
ama: Huang J, Zhao L, Malik S, et al. Specification of female germline by microRNA
orchestrated auxin signaling in Arabidopsis. Nature Communications. 2022;13.
doi:10.1038/s41467-022-34723-6
apa: Huang, J., Zhao, L., Malik, S., Gentile, B. R., Xiong, V., Arazi, T., … Zhao,
D. (2022). Specification of female germline by microRNA orchestrated auxin signaling
in Arabidopsis. Nature Communications. Springer Nature. https://doi.org/10.1038/s41467-022-34723-6
chicago: Huang, Jian, Lei Zhao, Shikha Malik, Benjamin R. Gentile, Va Xiong, Tzahi
Arazi, Heather A. Owen, Jiří Friml, and Dazhong Zhao. “Specification of Female
Germline by MicroRNA Orchestrated Auxin Signaling in Arabidopsis.” Nature Communications.
Springer Nature, 2022. https://doi.org/10.1038/s41467-022-34723-6.
ieee: J. Huang et al., “Specification of female germline by microRNA orchestrated
auxin signaling in Arabidopsis,” Nature Communications, vol. 13. Springer
Nature, 2022.
ista: Huang J, Zhao L, Malik S, Gentile BR, Xiong V, Arazi T, Owen HA, Friml J,
Zhao D. 2022. Specification of female germline by microRNA orchestrated auxin
signaling in Arabidopsis. Nature Communications. 13, 6960.
mla: Huang, Jian, et al. “Specification of Female Germline by MicroRNA Orchestrated
Auxin Signaling in Arabidopsis.” Nature Communications, vol. 13, 6960,
Springer Nature, 2022, doi:10.1038/s41467-022-34723-6.
short: J. Huang, L. Zhao, S. Malik, B.R. Gentile, V. Xiong, T. Arazi, H.A. Owen,
J. Friml, D. Zhao, Nature Communications 13 (2022).
date_created: 2023-01-12T12:02:41Z
date_published: 2022-11-15T00:00:00Z
date_updated: 2023-08-04T08:52:01Z
day: '15'
ddc:
- '580'
department:
- _id: JiFr
doi: 10.1038/s41467-022-34723-6
external_id:
isi:
- '000884426700001'
pmid:
- '36379956'
file:
- access_level: open_access
checksum: 233922a7b9507d9d48591e6799e4526e
content_type: application/pdf
creator: dernst
date_created: 2023-01-23T11:17:33Z
date_updated: 2023-01-23T11:17:33Z
file_id: '12346'
file_name: 2022_NatureCommunications_Huang.pdf
file_size: 3375249
relation: main_file
success: 1
file_date_updated: 2023-01-23T11:17:33Z
has_accepted_license: '1'
intvolume: ' 13'
isi: 1
keyword:
- General Physics and Astronomy
- General Biochemistry
- Genetics and Molecular Biology
- General Chemistry
- Multidisciplinary
language:
- iso: eng
month: '11'
oa: 1
oa_version: Published Version
pmid: 1
publication: Nature Communications
publication_identifier:
issn:
- 2041-1723
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
scopus_import: '1'
status: public
title: Specification of female germline by microRNA orchestrated auxin signaling in
Arabidopsis
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 13
year: '2022'
...
---
_id: '12131'
abstract:
- lang: eng
text: Replication-incompetent adenoviral vectors have been extensively used as a
platform for vaccine design, with at least four anti-COVID-19 vaccines authorized
to date. These vaccines elicit neutralizing antibody responses directed against
SARS-CoV-2 Spike protein and confer significant level of protection against SARS-CoV-2
infection. Immunization with adenovirus-vectored vaccines is known to be accompanied
by the production of anti-vector antibodies, which may translate into reduced
efficacy of booster or repeated rounds of revaccination. Here, we used blood samples
from patients who received an adenovirus-based Gam-COVID-Vac vaccine to address
the question of whether anti-vector antibodies may influence the magnitude of
SARS-CoV-2-specific humoral response after booster vaccination. We observed that
rAd26-based prime vaccination with Gam-COVID-Vac induced the development of Ad26-neutralizing
antibodies, which persisted in circulation for at least 9 months. Our analysis
further indicates that high pre-boost Ad26 neutralizing antibody titers do not
appear to affect the humoral immunogenicity of the Gam-COVID-Vac boost. The titers
of anti-SARS-CoV-2 RBD IgGs and antibodies, which neutralized both the wild type
and the circulating variants of concern of SARS-CoV-2 such as Delta and Omicron,
were independent of the pre-boost levels of Ad26-neutralizing antibodies. Thus,
our results support the development of repeated immunization schedule with adenovirus-based
COVID-19 vaccines.
acknowledgement: We thank Sergey Kulemzin, Grigory Efimov, Yuri Lebedin, Alexander
Taranin and Rudolf Valenta for providing reagents. Figures were created with the
help of BioRender.com. This work was supported by the Russian Science Foundation
(Project 21-15-00286). Byazrova M.G. was supported by the RUDN University Strategic
Academic Leadership Program.
article_number: '145'
article_processing_charge: No
article_type: original
author:
- first_name: Maria G.
full_name: Byazrova, Maria G.
last_name: Byazrova
- first_name: Ekaterina A.
full_name: Astakhova, Ekaterina A.
last_name: Astakhova
- first_name: Aygul
full_name: Minnegalieva, Aygul
id: 87DF77F0-1D9A-11EA-B6AE-CE443DDC885E
last_name: Minnegalieva
- first_name: Maria M.
full_name: Sukhova, Maria M.
last_name: Sukhova
- first_name: Artem A.
full_name: Mikhailov, Artem A.
last_name: Mikhailov
- first_name: Alexey G.
full_name: Prilipov, Alexey G.
last_name: Prilipov
- first_name: Andrey A.
full_name: Gorchakov, Andrey A.
last_name: Gorchakov
- first_name: Alexander V.
full_name: Filatov, Alexander V.
last_name: Filatov
citation:
ama: Byazrova MG, Astakhova EA, Minnegalieva A, et al. Anti-Ad26 humoral immunity
does not compromise SARS-COV-2 neutralizing antibody responses following Gam-COVID-Vac
booster vaccination. npj Vaccines. 2022;7. doi:10.1038/s41541-022-00566-x
apa: Byazrova, M. G., Astakhova, E. A., Minnegalieva, A., Sukhova, M. M., Mikhailov,
A. A., Prilipov, A. G., … Filatov, A. V. (2022). Anti-Ad26 humoral immunity does
not compromise SARS-COV-2 neutralizing antibody responses following Gam-COVID-Vac
booster vaccination. Npj Vaccines. Springer Nature. https://doi.org/10.1038/s41541-022-00566-x
chicago: Byazrova, Maria G., Ekaterina A. Astakhova, Aygul Minnegalieva, Maria M.
Sukhova, Artem A. Mikhailov, Alexey G. Prilipov, Andrey A. Gorchakov, and Alexander
V. Filatov. “Anti-Ad26 Humoral Immunity Does Not Compromise SARS-COV-2 Neutralizing
Antibody Responses Following Gam-COVID-Vac Booster Vaccination.” Npj Vaccines.
Springer Nature, 2022. https://doi.org/10.1038/s41541-022-00566-x.
ieee: M. G. Byazrova et al., “Anti-Ad26 humoral immunity does not compromise
SARS-COV-2 neutralizing antibody responses following Gam-COVID-Vac booster vaccination,”
npj Vaccines, vol. 7. Springer Nature, 2022.
ista: Byazrova MG, Astakhova EA, Minnegalieva A, Sukhova MM, Mikhailov AA, Prilipov
AG, Gorchakov AA, Filatov AV. 2022. Anti-Ad26 humoral immunity does not compromise
SARS-COV-2 neutralizing antibody responses following Gam-COVID-Vac booster vaccination.
npj Vaccines. 7, 145.
mla: Byazrova, Maria G., et al. “Anti-Ad26 Humoral Immunity Does Not Compromise
SARS-COV-2 Neutralizing Antibody Responses Following Gam-COVID-Vac Booster Vaccination.”
Npj Vaccines, vol. 7, 145, Springer Nature, 2022, doi:10.1038/s41541-022-00566-x.
short: M.G. Byazrova, E.A. Astakhova, A. Minnegalieva, M.M. Sukhova, A.A. Mikhailov,
A.G. Prilipov, A.A. Gorchakov, A.V. Filatov, Npj Vaccines 7 (2022).
date_created: 2023-01-12T12:02:54Z
date_published: 2022-11-15T00:00:00Z
date_updated: 2023-08-04T08:52:40Z
day: '15'
ddc:
- '570'
department:
- _id: FyKo
doi: 10.1038/s41541-022-00566-x
external_id:
isi:
- '000884278600004'
pmid:
- '36379998'
file:
- access_level: open_access
checksum: ddaac096381565b2b4b7dcc34cdbc4ee
content_type: application/pdf
creator: dernst
date_created: 2023-01-23T11:22:09Z
date_updated: 2023-01-23T11:22:09Z
file_id: '12347'
file_name: 2022_njpVaccines_Byazrova.pdf
file_size: 1856046
relation: main_file
success: 1
file_date_updated: 2023-01-23T11:22:09Z
has_accepted_license: '1'
intvolume: ' 7'
isi: 1
keyword:
- Pharmacology (medical)
- Infectious Diseases
- Pharmacology
- Immunology
- SARS-COV-2
- COVID
language:
- iso: eng
month: '11'
oa: 1
oa_version: Published Version
pmid: 1
publication: npj Vaccines
publication_identifier:
issn:
- 2059-0105
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
scopus_import: '1'
status: public
title: Anti-Ad26 humoral immunity does not compromise SARS-COV-2 neutralizing antibody
responses following Gam-COVID-Vac booster vaccination
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 7
year: '2022'
...
---
_id: '12133'
abstract:
- lang: eng
text: Social distancing is an effective way to prevent the spread of disease in
societies, whereas infection elimination is a key element of organismal immunity.
Here, we discuss how the study of social insects such as ants — which form a superorganism
of unconditionally cooperative individuals and thus represent a level of organization
that is intermediate between a classical society of individuals and an organism
of cells — can help to determine common principles of disease defence across levels
of organization.
article_processing_charge: No
article_type: letter_note
author:
- first_name: Sylvia
full_name: Cremer, Sylvia
id: 2F64EC8C-F248-11E8-B48F-1D18A9856A87
last_name: Cremer
orcid: 0000-0002-2193-3868
- first_name: Michael K
full_name: Sixt, Michael K
id: 41E9FBEA-F248-11E8-B48F-1D18A9856A87
last_name: Sixt
orcid: 0000-0002-6620-9179
citation:
ama: Cremer S, Sixt MK. Principles of disease defence in organisms, superorganisms
and societies. Nature Reviews Immunology. 2022;22(12):713-714. doi:10.1038/s41577-022-00797-y
apa: Cremer, S., & Sixt, M. K. (2022). Principles of disease defence in organisms,
superorganisms and societies. Nature Reviews Immunology. Springer Nature.
https://doi.org/10.1038/s41577-022-00797-y
chicago: Cremer, Sylvia, and Michael K Sixt. “Principles of Disease Defence in Organisms,
Superorganisms and Societies.” Nature Reviews Immunology. Springer Nature,
2022. https://doi.org/10.1038/s41577-022-00797-y.
ieee: S. Cremer and M. K. Sixt, “Principles of disease defence in organisms, superorganisms
and societies,” Nature Reviews Immunology, vol. 22, no. 12. Springer Nature,
pp. 713–714, 2022.
ista: Cremer S, Sixt MK. 2022. Principles of disease defence in organisms, superorganisms
and societies. Nature Reviews Immunology. 22(12), 713–714.
mla: Cremer, Sylvia, and Michael K. Sixt. “Principles of Disease Defence in Organisms,
Superorganisms and Societies.” Nature Reviews Immunology, vol. 22, no.
12, Springer Nature, 2022, pp. 713–14, doi:10.1038/s41577-022-00797-y.
short: S. Cremer, M.K. Sixt, Nature Reviews Immunology 22 (2022) 713–714.
date_created: 2023-01-12T12:03:14Z
date_published: 2022-12-01T00:00:00Z
date_updated: 2023-08-04T08:53:32Z
day: '01'
department:
- _id: SyCr
- _id: MiSi
doi: 10.1038/s41577-022-00797-y
external_id:
isi:
- '000871836300001'
pmid:
- '36284178'
intvolume: ' 22'
isi: 1
issue: '12'
keyword:
- Energy Engineering and Power Technology
- Fuel Technology
language:
- iso: eng
month: '12'
oa_version: None
page: 713-714
pmid: 1
publication: Nature Reviews Immunology
publication_identifier:
eissn:
- 1474-1741
issn:
- 1474-1733
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
scopus_import: '1'
status: public
title: Principles of disease defence in organisms, superorganisms and societies
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 22
year: '2022'
...
---
_id: '12134'
abstract:
- lang: eng
text: Standard epidemic models exhibit one continuous, second order phase transition
to macroscopic outbreaks. However, interventions to control outbreaks may fundamentally
alter epidemic dynamics. Here we reveal how such interventions modify the type
of phase transition. In particular, we uncover three distinct types of explosive
phase transitions for epidemic dynamics with capacity-limited interventions. Depending
on the capacity limit, interventions may (i) leave the standard second order phase
transition unchanged but exponentially suppress the probability of large outbreaks,
(ii) induce a first-order discontinuous transition to macroscopic outbreaks, or
(iii) cause a secondary explosive yet continuous third-order transition. These
insights highlight inherent limitations in predicting and containing epidemic
outbreaks. More generally our study offers a cornerstone example of a third-order
explosive phase transition in complex systems.
acknowledgement: We acknowledge support from the Volkswagen Foundation under Grant
No. 99720 and the German Federal Ministry for Education and Research (BMBF) under
Grant No. 16ICR01. This research was supported by the Deutsche Forschungsgemeinschaft
(DFG, German Research Foundation) under Germany’s Excellence Strategy—EXC-2068—390729961—Cluster
of Excellence Physics of Life of TU Dresden.
article_number: 04LT02
article_processing_charge: No
article_type: original
author:
- first_name: Georg
full_name: Börner, Georg
last_name: Börner
- first_name: Malte
full_name: Schröder, Malte
last_name: Schröder
- first_name: Davide
full_name: Scarselli, Davide
id: 40315C30-F248-11E8-B48F-1D18A9856A87
last_name: Scarselli
orcid: 0000-0001-5227-4271
- first_name: Nazmi B
full_name: Budanur, Nazmi B
id: 3EA1010E-F248-11E8-B48F-1D18A9856A87
last_name: Budanur
orcid: 0000-0003-0423-5010
- first_name: Björn
full_name: Hof, Björn
id: 3A374330-F248-11E8-B48F-1D18A9856A87
last_name: Hof
orcid: 0000-0003-2057-2754
- first_name: Marc
full_name: Timme, Marc
last_name: Timme
citation:
ama: 'Börner G, Schröder M, Scarselli D, Budanur NB, Hof B, Timme M. Explosive transitions
in epidemic dynamics. Journal of Physics: Complexity. 2022;3(4). doi:10.1088/2632-072x/ac99cd'
apa: 'Börner, G., Schröder, M., Scarselli, D., Budanur, N. B., Hof, B., & Timme,
M. (2022). Explosive transitions in epidemic dynamics. Journal of Physics:
Complexity. IOP Publishing. https://doi.org/10.1088/2632-072x/ac99cd'
chicago: 'Börner, Georg, Malte Schröder, Davide Scarselli, Nazmi B Budanur, Björn
Hof, and Marc Timme. “Explosive Transitions in Epidemic Dynamics.” Journal
of Physics: Complexity. IOP Publishing, 2022. https://doi.org/10.1088/2632-072x/ac99cd.'
ieee: 'G. Börner, M. Schröder, D. Scarselli, N. B. Budanur, B. Hof, and M. Timme,
“Explosive transitions in epidemic dynamics,” Journal of Physics: Complexity,
vol. 3, no. 4. IOP Publishing, 2022.'
ista: 'Börner G, Schröder M, Scarselli D, Budanur NB, Hof B, Timme M. 2022. Explosive
transitions in epidemic dynamics. Journal of Physics: Complexity. 3(4), 04LT02.'
mla: 'Börner, Georg, et al. “Explosive Transitions in Epidemic Dynamics.” Journal
of Physics: Complexity, vol. 3, no. 4, 04LT02, IOP Publishing, 2022, doi:10.1088/2632-072x/ac99cd.'
short: 'G. Börner, M. Schröder, D. Scarselli, N.B. Budanur, B. Hof, M. Timme, Journal
of Physics: Complexity 3 (2022).'
date_created: 2023-01-12T12:03:43Z
date_published: 2022-10-25T00:00:00Z
date_updated: 2023-02-13T09:15:13Z
day: '25'
ddc:
- '530'
department:
- _id: BjHo
doi: 10.1088/2632-072x/ac99cd
file:
- access_level: open_access
checksum: 35c5c5cb0eb17ea1b5184755daab9fc9
content_type: application/pdf
creator: dernst
date_created: 2023-01-24T07:24:37Z
date_updated: 2023-01-24T07:24:37Z
file_id: '12350'
file_name: 2022_JourPhysics_Boerner.pdf
file_size: 1006106
relation: main_file
success: 1
file_date_updated: 2023-01-24T07:24:37Z
has_accepted_license: '1'
intvolume: ' 3'
issue: '4'
keyword:
- Artificial Intelligence
- Computer Networks and Communications
- Computer Science Applications
- Information Systems
language:
- iso: eng
month: '10'
oa: 1
oa_version: Published Version
publication: 'Journal of Physics: Complexity'
publication_identifier:
issn:
- 2632-072X
publication_status: published
publisher: IOP Publishing
quality_controlled: '1'
scopus_import: '1'
status: public
title: Explosive transitions in epidemic dynamics
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 3
year: '2022'
...
---
_id: '12135'
abstract:
- lang: eng
text: A good match of material appearance between real-world objects and their digital
on-screen representations is critical for many applications such as fabrication,
design, and e-commerce. However, faithful appearance reproduction is challenging,
especially for complex phenomena, such as gloss. In most cases, the view-dependent
nature of gloss and the range of luminance values required for reproducing glossy
materials exceeds the current capabilities of display devices. As a result, appearance
reproduction poses significant problems even with accurately rendered images.
This paper studies the gap between the gloss perceived from real-world objects
and their digital counterparts. Based on our psychophysical experiments on a wide
range of 3D printed samples and their corresponding photographs, we derive insights
on the influence of geometry, illumination, and the display’s brightness and measure
the change in gloss appearance due to the display limitations. Our evaluation
experiments demonstrate that using the prediction to correct material parameters
in a rendering system improves the match of gloss appearance between real objects
and their visualization on a display device.
acknowledgement: This work is supported by FWF Lise Meitner (Grant M 3319), European
Research Council (project CHAMELEON, Grant no. 682080), Swiss National Science Foundation
(Grant no. 200502), and academic gifts from Meta.
article_number: '35'
article_processing_charge: No
author:
- first_name: Bin
full_name: Chen, Bin
last_name: Chen
- first_name: Michael
full_name: Piovarci, Michael
id: 62E473F4-5C99-11EA-A40E-AF823DDC885E
last_name: Piovarci
- first_name: Chao
full_name: Wang, Chao
last_name: Wang
- first_name: Hans-Peter
full_name: Seidel, Hans-Peter
last_name: Seidel
- first_name: Piotr
full_name: Didyk, Piotr
last_name: Didyk
- first_name: Karol
full_name: Myszkowski, Karol
last_name: Myszkowski
- first_name: Ana
full_name: Serrano, Ana
last_name: Serrano
citation:
ama: 'Chen B, Piovarci M, Wang C, et al. Gloss management for consistent reproduction
of real and virtual objects. In: SIGGRAPH Asia 2022 Conference Papers.
Vol 2022. Association for Computing Machinery; 2022. doi:10.1145/3550469.3555406'
apa: 'Chen, B., Piovarci, M., Wang, C., Seidel, H.-P., Didyk, P., Myszkowski, K.,
& Serrano, A. (2022). Gloss management for consistent reproduction of real
and virtual objects. In SIGGRAPH Asia 2022 Conference Papers (Vol. 2022).
Daegu, South Korea: Association for Computing Machinery. https://doi.org/10.1145/3550469.3555406'
chicago: Chen, Bin, Michael Piovarci, Chao Wang, Hans-Peter Seidel, Piotr Didyk,
Karol Myszkowski, and Ana Serrano. “Gloss Management for Consistent Reproduction
of Real and Virtual Objects.” In SIGGRAPH Asia 2022 Conference Papers,
Vol. 2022. Association for Computing Machinery, 2022. https://doi.org/10.1145/3550469.3555406.
ieee: B. Chen et al., “Gloss management for consistent reproduction of real
and virtual objects,” in SIGGRAPH Asia 2022 Conference Papers, Daegu, South
Korea, 2022, vol. 2022.
ista: 'Chen B, Piovarci M, Wang C, Seidel H-P, Didyk P, Myszkowski K, Serrano A.
2022. Gloss management for consistent reproduction of real and virtual objects.
SIGGRAPH Asia 2022 Conference Papers. SIGGRAPH: Computer Graphics and Interactive
Techniques Conference vol. 2022, 35.'
mla: Chen, Bin, et al. “Gloss Management for Consistent Reproduction of Real and
Virtual Objects.” SIGGRAPH Asia 2022 Conference Papers, vol. 2022, 35,
Association for Computing Machinery, 2022, doi:10.1145/3550469.3555406.
short: B. Chen, M. Piovarci, C. Wang, H.-P. Seidel, P. Didyk, K. Myszkowski, A.
Serrano, in:, SIGGRAPH Asia 2022 Conference Papers, Association for Computing
Machinery, 2022.
conference:
end_date: 2022-12-09
location: Daegu, South Korea
name: 'SIGGRAPH: Computer Graphics and Interactive Techniques Conference'
start_date: 2022-12-06
date_created: 2023-01-12T12:03:56Z
date_published: 2022-11-01T00:00:00Z
date_updated: 2023-02-13T09:15:25Z
day: '01'
ddc:
- '000'
department:
- _id: BeBi
doi: 10.1145/3550469.3555406
file:
- access_level: open_access
checksum: f47f3215ab8bb919e3546b3438c34c21
content_type: application/pdf
creator: dernst
date_created: 2023-01-24T07:35:21Z
date_updated: 2023-01-24T07:35:21Z
file_id: '12351'
file_name: 2022_ACM_SIGGRAPH_Chen.pdf
file_size: 28826826
relation: main_file
success: 1
file_date_updated: 2023-01-24T07:35:21Z
has_accepted_license: '1'
intvolume: ' 2022'
language:
- iso: eng
month: '11'
oa: 1
oa_version: Published Version
project:
- _id: eb901961-77a9-11ec-83b8-f5c883a62027
grant_number: M03319
name: Perception-Aware Appearance Fabrication
publication: SIGGRAPH Asia 2022 Conference Papers
publication_identifier:
isbn:
- '9781450394703'
publication_status: published
publisher: Association for Computing Machinery
quality_controlled: '1'
scopus_import: '1'
status: public
title: Gloss management for consistent reproduction of real and virtual objects
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: conference
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 2022
year: '2022'
...
---
_id: '12137'
abstract:
- lang: eng
text: We investigate the local self-sustained process underlying spiral turbulence
in counter-rotating Taylor–Couette flow using a periodic annular domain, shaped
as a parallelogram, two of whose sides are aligned with the cylindrical helix
described by the spiral pattern. The primary focus of the study is placed on the
emergence of drifting–rotating waves (DRW) that capture, in a relatively small
domain, the main features of coherent structures typically observed in developed
turbulence. The transitional dynamics of the subcritical region, far below the
first instability of the laminar circular Couette flow, is determined by the upper
and lower branches of DRW solutions originated at saddle-node bifurcations. The
mechanism whereby these solutions self-sustain, and the chaotic dynamics they
induce, are conspicuously reminiscent of other subcritical shear flows. Remarkably,
the flow properties of DRW persist even as the Reynolds number is increased beyond
the linear stability threshold of the base flow. Simulations in a narrow parallelogram
domain stretched in the azimuthal direction to revolve around the apparatus a
full turn confirm that self-sustained vortices eventually concentrate into a localised
pattern. The resulting statistical steady state satisfactorily reproduces qualitatively,
and to a certain degree also quantitatively, the topology and properties of spiral
turbulence as calculated in a large periodic domain of sufficient aspect ratio
that is representative of the real system.
acknowledgement: "K.D.’s research was supported by an Australian Research Council
Discovery Early Career\r\nResearcher Award (DE170100171). B.W., R.A., F.M. and A.M.
research was supported by the Spanish Ministerio de Economía y Competitivdad (grant
numbers FIS2016-77849-R and FIS2017-85794-P) and Ministerio de Ciencia e Innovación
(grant number PID2020-114043GB-I00) and the Generalitat de Catalunya (grant 2017-SGR-785).
B.W.’s research was also supported by the Chinese Scholarship Council (grant CSC
no. 201806440152)."
article_number: A21
article_processing_charge: No
article_type: original
arxiv: 1
author:
- first_name: B.
full_name: Wang, B.
last_name: Wang
- first_name: Roger
full_name: Ayats López, Roger
id: ab77522d-073b-11ed-8aff-e71b39258362
last_name: Ayats López
orcid: 0000-0001-6572-0621
- first_name: K.
full_name: Deguchi, K.
last_name: Deguchi
- first_name: F.
full_name: Mellibovsky, F.
last_name: Mellibovsky
- first_name: A.
full_name: Meseguer, A.
last_name: Meseguer
citation:
ama: Wang B, Ayats López R, Deguchi K, Mellibovsky F, Meseguer A. Self-sustainment
of coherent structures in counter-rotating Taylor–Couette flow. Journal of
Fluid Mechanics. 2022;951. doi:10.1017/jfm.2022.828
apa: Wang, B., Ayats López, R., Deguchi, K., Mellibovsky, F., & Meseguer, A.
(2022). Self-sustainment of coherent structures in counter-rotating Taylor–Couette
flow. Journal of Fluid Mechanics. Cambridge University Press. https://doi.org/10.1017/jfm.2022.828
chicago: Wang, B., Roger Ayats López, K. Deguchi, F. Mellibovsky, and A. Meseguer.
“Self-Sustainment of Coherent Structures in Counter-Rotating Taylor–Couette Flow.”
Journal of Fluid Mechanics. Cambridge University Press, 2022. https://doi.org/10.1017/jfm.2022.828.
ieee: B. Wang, R. Ayats López, K. Deguchi, F. Mellibovsky, and A. Meseguer, “Self-sustainment
of coherent structures in counter-rotating Taylor–Couette flow,” Journal of
Fluid Mechanics, vol. 951. Cambridge University Press, 2022.
ista: Wang B, Ayats López R, Deguchi K, Mellibovsky F, Meseguer A. 2022. Self-sustainment
of coherent structures in counter-rotating Taylor–Couette flow. Journal of Fluid
Mechanics. 951, A21.
mla: Wang, B., et al. “Self-Sustainment of Coherent Structures in Counter-Rotating
Taylor–Couette Flow.” Journal of Fluid Mechanics, vol. 951, A21, Cambridge
University Press, 2022, doi:10.1017/jfm.2022.828.
short: B. Wang, R. Ayats López, K. Deguchi, F. Mellibovsky, A. Meseguer, Journal
of Fluid Mechanics 951 (2022).
date_created: 2023-01-12T12:04:17Z
date_published: 2022-11-07T00:00:00Z
date_updated: 2023-08-04T08:54:16Z
day: '07'
department:
- _id: BjHo
doi: 10.1017/jfm.2022.828
external_id:
arxiv:
- '2207.12990'
isi:
- '000879446900001'
intvolume: ' 951'
isi: 1
keyword:
- Mechanical Engineering
- Mechanics of Materials
- Condensed Matter Physics
- Applied Mathematics
language:
- iso: eng
main_file_link:
- open_access: '1'
url: ' https://doi.org/10.48550/arXiv.2207.12990'
month: '11'
oa: 1
oa_version: Preprint
publication: Journal of Fluid Mechanics
publication_identifier:
eissn:
- 1469-7645
issn:
- 0022-1120
publication_status: published
publisher: Cambridge University Press
quality_controlled: '1'
scopus_import: '1'
status: public
title: Self-sustainment of coherent structures in counter-rotating Taylor–Couette
flow
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 951
year: '2022'
...
---
_id: '12138'
abstract:
- lang: eng
text: 'Complex I is the first enzyme in the respiratory chain, which is responsible
for energy production in mitochondria and bacteria1. Complex I couples the transfer
of two electrons from NADH to quinone and the translocation of four protons across
the membrane2, but the coupling mechanism remains contentious. Here we present
cryo-electron microscopy structures of Escherichia coli complex I (EcCI) in different
redox states, including catalytic turnover. EcCI exists mostly in the open state,
in which the quinone cavity is exposed to the cytosol, allowing access for water
molecules, which enable quinone movements. Unlike the mammalian paralogues3, EcCI
can convert to the closed state only during turnover, showing that closed and
open states are genuine turnover intermediates. The open-to-closed transition
results in the tightly engulfed quinone cavity being connected to the central
axis of the membrane arm, a source of substrate protons. Consistently, the proportion
of the closed state increases with increasing pH. We propose a detailed but straightforward
and robust mechanism comprising a ‘domino effect’ series of proton transfers and
electrostatic interactions: the forward wave (‘dominoes stacking’) primes the
pump, and the reverse wave (‘dominoes falling’) results in the ejection of all
pumped protons from the distal subunit NuoL. This mechanism explains why protons
exit exclusively from the NuoL subunit and is supported by our mutagenesis data.
We contend that this is a universal coupling mechanism of complex I and related
enzymes.'
acknowledged_ssus:
- _id: EM-Fac
- _id: LifeSc
- _id: ScienComp
acknowledgement: This research was supported by the Scientific Service Units (SSU)
of IST Austria through resources provided by the Electron Microscopy Facility (EMF),
the Life Science Facility (LSF) and the IST high-performance computing cluster.
We thank V.-V. Hodirnau from IST Austria EMF, M. Babiak from CEITEC for assistance
with collecting cryo-EM data and A. Charnagalov for the assistance with protein
purification. V.K. was a recipient of a DOC Fellowship of the Austrian Academy of
Sciences at the Institute of Science and Technology, Austria. V.K. and O.P. are
funded by the ERC Advanced Grant 101020697 RESPICHAIN to L.S. This work was also
supported by the Medical Research Council (UK).
article_processing_charge: No
article_type: original
author:
- first_name: Vladyslav
full_name: Kravchuk, Vladyslav
id: 4D62F2A6-F248-11E8-B48F-1D18A9856A87
last_name: Kravchuk
- first_name: Olga
full_name: Petrova, Olga
id: 5D8C9660-5D49-11EA-8188-567B3DDC885E
last_name: Petrova
- first_name: Domen
full_name: Kampjut, Domen
id: 37233050-F248-11E8-B48F-1D18A9856A87
last_name: Kampjut
- first_name: Anna
full_name: Wojciechowska-Bason, Anna
last_name: Wojciechowska-Bason
- first_name: Zara
full_name: Breese, Zara
last_name: Breese
- first_name: Leonid A
full_name: Sazanov, Leonid A
id: 338D39FE-F248-11E8-B48F-1D18A9856A87
last_name: Sazanov
orcid: 0000-0002-0977-7989
citation:
ama: Kravchuk V, Petrova O, Kampjut D, Wojciechowska-Bason A, Breese Z, Sazanov
LA. A universal coupling mechanism of respiratory complex I. Nature. 2022;609(7928):808-814.
doi:10.1038/s41586-022-05199-7
apa: Kravchuk, V., Petrova, O., Kampjut, D., Wojciechowska-Bason, A., Breese, Z.,
& Sazanov, L. A. (2022). A universal coupling mechanism of respiratory complex
I. Nature. Springer Nature. https://doi.org/10.1038/s41586-022-05199-7
chicago: Kravchuk, Vladyslav, Olga Petrova, Domen Kampjut, Anna Wojciechowska-Bason,
Zara Breese, and Leonid A Sazanov. “A Universal Coupling Mechanism of Respiratory
Complex I.” Nature. Springer Nature, 2022. https://doi.org/10.1038/s41586-022-05199-7.
ieee: V. Kravchuk, O. Petrova, D. Kampjut, A. Wojciechowska-Bason, Z. Breese, and
L. A. Sazanov, “A universal coupling mechanism of respiratory complex I,” Nature,
vol. 609, no. 7928. Springer Nature, pp. 808–814, 2022.
ista: Kravchuk V, Petrova O, Kampjut D, Wojciechowska-Bason A, Breese Z, Sazanov
LA. 2022. A universal coupling mechanism of respiratory complex I. Nature. 609(7928),
808–814.
mla: Kravchuk, Vladyslav, et al. “A Universal Coupling Mechanism of Respiratory
Complex I.” Nature, vol. 609, no. 7928, Springer Nature, 2022, pp. 808–14,
doi:10.1038/s41586-022-05199-7.
short: V. Kravchuk, O. Petrova, D. Kampjut, A. Wojciechowska-Bason, Z. Breese, L.A.
Sazanov, Nature 609 (2022) 808–814.
date_created: 2023-01-12T12:04:33Z
date_published: 2022-09-22T00:00:00Z
date_updated: 2023-08-04T08:54:52Z
day: '22'
ddc:
- '572'
department:
- _id: LeSa
doi: 10.1038/s41586-022-05199-7
ec_funded: 1
external_id:
isi:
- '000854788200001'
pmid:
- '36104567'
file:
- access_level: open_access
checksum: d42a93e24f59e883ef0b5429832391d0
content_type: application/pdf
creator: lsazanov
date_created: 2023-05-30T17:05:31Z
date_updated: 2023-05-30T17:05:31Z
file_id: '13104'
file_name: EcCxI_manuscript_rev3_noSI_updated_withFigs_opt.pdf
file_size: 1425655
relation: main_file
success: 1
- access_level: open_access
checksum: 5422bc0a73b3daadafa262c7ea6deae3
content_type: application/pdf
creator: lsazanov
date_created: 2023-05-30T17:07:05Z
date_updated: 2023-05-30T17:07:05Z
file_id: '13105'
file_name: EcCxI_manuscript_rev3_SI_All_opt_upd.pdf
file_size: 9842513
relation: main_file
success: 1
file_date_updated: 2023-05-30T17:07:05Z
has_accepted_license: '1'
intvolume: ' 609'
isi: 1
issue: '7928'
keyword:
- Multidisciplinary
language:
- iso: eng
month: '09'
oa: 1
oa_version: Submitted Version
page: 808-814
pmid: 1
project:
- _id: 238A0A5A-32DE-11EA-91FC-C7463DDC885E
grant_number: '25541'
name: 'Structural characterization of E. coli complex I: an important mechanistic
model'
- _id: 627abdeb-2b32-11ec-9570-ec31a97243d3
call_identifier: H2020
grant_number: '101020697'
name: Structure and mechanism of respiratory chain molecular machines
publication: Nature
publication_identifier:
eissn:
- 1476-4687
issn:
- 0028-0836
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
related_material:
link:
- relation: erratum
url: https://doi.org/10.1038/s41586-022-05457-8
- description: News on ISTA website
relation: press_release
url: https://ista.ac.at/en/news/proton-dominos-kick-off-life/
record:
- id: '12781'
relation: dissertation_contains
status: public
scopus_import: '1'
status: public
title: A universal coupling mechanism of respiratory complex I
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 609
year: '2022'
...
---
_id: '12139'
abstract:
- lang: eng
text: We demonstrate the formation of robust zero-energy modes close to magnetic
impurities in the iron-based superconductor FeSe1-z Tez. We find that the Zeeman
field generated by the impurity favors a spin-triplet interorbital pairing as
opposed to the spin-singlet intraorbital pairing prevalent in the bulk. The preferred
spin-triplet pairing preserves time-reversal symmetry and is topological, as robust,
topologically protected zero modes emerge at the boundary between regions with
different pairing states. Moreover, the zero modes form Kramers doublets that
are insensitive to the direction of the spin polarization or to the separation
between impurities. We argue that our theoretical results are consistent with
recent experimental measurements on FeSe1-z Tez.
acknowledgement: "We thank Armin Rahmani, Andrey V. Chubukov, Jay D. Sau and Ruixing
Zhang for fruitful discussions. AK and PG are supported by NSF-DMR2037996. PG also
acknowledges support from NSF-DMR1824265. RMF was supported by the U. S. Department
of Energy, Office\r\nof Science, Basic Energy Sciences, Materials Sciences and Engineering
Division, under Award No. DE-SC0020045. Part of this work was performed at the Aspen
Center for Physics, which is supported by National Science Foundation grant PHY-1607611. "
article_number: L201107
article_processing_charge: No
article_type: original
arxiv: 1
author:
- first_name: Areg
full_name: Ghazaryan, Areg
id: 4AF46FD6-F248-11E8-B48F-1D18A9856A87
last_name: Ghazaryan
orcid: 0000-0001-9666-3543
- first_name: Ammar
full_name: Kirmani, Ammar
last_name: Kirmani
- first_name: Rafael M.
full_name: Fernandes, Rafael M.
last_name: Fernandes
- first_name: Pouyan
full_name: Ghaemi, Pouyan
last_name: Ghaemi
citation:
ama: Ghazaryan A, Kirmani A, Fernandes RM, Ghaemi P. Anomalous Shiba states in topological
iron-based superconductors. Physical Review B. 2022;106(20). doi:10.1103/physrevb.106.l201107
apa: Ghazaryan, A., Kirmani, A., Fernandes, R. M., & Ghaemi, P. (2022). Anomalous
Shiba states in topological iron-based superconductors. Physical Review B.
American Physical Society. https://doi.org/10.1103/physrevb.106.l201107
chicago: Ghazaryan, Areg, Ammar Kirmani, Rafael M. Fernandes, and Pouyan Ghaemi.
“Anomalous Shiba States in Topological Iron-Based Superconductors.” Physical
Review B. American Physical Society, 2022. https://doi.org/10.1103/physrevb.106.l201107.
ieee: A. Ghazaryan, A. Kirmani, R. M. Fernandes, and P. Ghaemi, “Anomalous Shiba
states in topological iron-based superconductors,” Physical Review B, vol.
106, no. 20. American Physical Society, 2022.
ista: Ghazaryan A, Kirmani A, Fernandes RM, Ghaemi P. 2022. Anomalous Shiba states
in topological iron-based superconductors. Physical Review B. 106(20), L201107.
mla: Ghazaryan, Areg, et al. “Anomalous Shiba States in Topological Iron-Based Superconductors.”
Physical Review B, vol. 106, no. 20, L201107, American Physical Society,
2022, doi:10.1103/physrevb.106.l201107.
short: A. Ghazaryan, A. Kirmani, R.M. Fernandes, P. Ghaemi, Physical Review B 106
(2022).
date_created: 2023-01-12T12:04:43Z
date_published: 2022-11-15T00:00:00Z
date_updated: 2023-08-04T08:55:31Z
day: '15'
department:
- _id: MiLe
doi: 10.1103/physrevb.106.l201107
external_id:
arxiv:
- '2207.12425'
isi:
- '000893171800001'
intvolume: ' 106'
isi: 1
issue: '20'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: ' https://doi.org/10.48550/arXiv.2207.12425'
month: '11'
oa: 1
oa_version: Preprint
publication: Physical Review B
publication_identifier:
eissn:
- 2469-9969
issn:
- 2469-9950
publication_status: published
publisher: American Physical Society
quality_controlled: '1'
scopus_import: '1'
status: public
title: Anomalous Shiba states in topological iron-based superconductors
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 106
year: '2022'
...
---
_id: '12140'
abstract:
- lang: eng
text: Microglia are dynamic cells, constantly surveying their surroundings and interacting
with neurons and synapses. Indeed, a wealth of knowledge has revealed a critical
role of microglia in modulating synaptic transmission and plasticity in the developing
brain. In the past decade, novel pharmacological and genetic strategies have allowed
the acute removal of microglia, opening the possibility to explore and understand
the role of microglia also in the adult brain. In this review, we summarized and
discussed the contribution of microglia depletion strategies to the current understanding
of the role of microglia on synaptic function, learning and memory, and behavior
both in physiological and pathological conditions. We first described the available
microglia depletion methods highlighting their main strengths and weaknesses.
We then reviewed the impact of microglia depletion on structural and functional
synaptic plasticity. Next, we focused our analysis on the effects of microglia
depletion on behavior, including general locomotor activity, sensory perception,
motor function, sociability, learning and memory both in healthy animals and animal
models of disease. Finally, we integrated the findings from the reviewed studies
and discussed the emerging roles of microglia on the maintenance of synaptic function,
learning, memory strength and forgetfulness, and the implications of microglia
depletion in models of brain disease.
acknowledgement: "The write-up of the review was supported by Sapienza University
of Rome (Fondi di Ateneo, grant numbers #MA32117A7B698029 and #PH12017270934C3C
to SD), Regione Lazio (POR FSE 2014/20, grant number #19036AP000000019 to SD), Fulbright
2019 (grant number\r\n#FSP-P005556 to SD), Institute Pasteur Italia (Fondi Cenci
Bolognetti #363 to DR), and Network of European Funding for Neuroscience Research
(ERA-NET NEURON Transnational\r\nResearch Projects on Neurodevelopmental Disorders
2021, grant acronym #JTC2021-SHANKAstro to DR)."
article_number: '1022431'
article_processing_charge: No
article_type: original
author:
- first_name: Bernadette
full_name: Basilico, Bernadette
id: 36035796-5ACA-11E9-A75E-7AF2E5697425
last_name: Basilico
orcid: 0000-0003-1843-3173
- first_name: Laura
full_name: Ferrucci, Laura
last_name: Ferrucci
- first_name: Azka
full_name: Khan, Azka
last_name: Khan
- first_name: Silvia
full_name: Di Angelantonio, Silvia
last_name: Di Angelantonio
- first_name: Davide
full_name: Ragozzino, Davide
last_name: Ragozzino
- first_name: Ingrid
full_name: Reverte, Ingrid
last_name: Reverte
citation:
ama: Basilico B, Ferrucci L, Khan A, Di Angelantonio S, Ragozzino D, Reverte I.
What microglia depletion approaches tell us about the role of microglia on synaptic
function and behavior. Frontiers in Cellular Neuroscience. 2022;16. doi:10.3389/fncel.2022.1022431
apa: Basilico, B., Ferrucci, L., Khan, A., Di Angelantonio, S., Ragozzino, D., &
Reverte, I. (2022). What microglia depletion approaches tell us about the role
of microglia on synaptic function and behavior. Frontiers in Cellular Neuroscience.
Frontiers Media. https://doi.org/10.3389/fncel.2022.1022431
chicago: Basilico, Bernadette, Laura Ferrucci, Azka Khan, Silvia Di Angelantonio,
Davide Ragozzino, and Ingrid Reverte. “What Microglia Depletion Approaches Tell
Us about the Role of Microglia on Synaptic Function and Behavior.” Frontiers
in Cellular Neuroscience. Frontiers Media, 2022. https://doi.org/10.3389/fncel.2022.1022431.
ieee: B. Basilico, L. Ferrucci, A. Khan, S. Di Angelantonio, D. Ragozzino, and I.
Reverte, “What microglia depletion approaches tell us about the role of microglia
on synaptic function and behavior,” Frontiers in Cellular Neuroscience,
vol. 16. Frontiers Media, 2022.
ista: Basilico B, Ferrucci L, Khan A, Di Angelantonio S, Ragozzino D, Reverte I.
2022. What microglia depletion approaches tell us about the role of microglia
on synaptic function and behavior. Frontiers in Cellular Neuroscience. 16, 1022431.
mla: Basilico, Bernadette, et al. “What Microglia Depletion Approaches Tell Us about
the Role of Microglia on Synaptic Function and Behavior.” Frontiers in Cellular
Neuroscience, vol. 16, 1022431, Frontiers Media, 2022, doi:10.3389/fncel.2022.1022431.
short: B. Basilico, L. Ferrucci, A. Khan, S. Di Angelantonio, D. Ragozzino, I. Reverte,
Frontiers in Cellular Neuroscience 16 (2022).
date_created: 2023-01-12T12:04:50Z
date_published: 2022-11-04T00:00:00Z
date_updated: 2023-08-04T08:56:10Z
day: '04'
ddc:
- '570'
department:
- _id: GaNo
doi: 10.3389/fncel.2022.1022431
external_id:
isi:
- '000886526600001'
pmid:
- '36406752'
file:
- access_level: open_access
checksum: 84696213ecf99182c58a9f34b9ff2e23
content_type: application/pdf
creator: dernst
date_created: 2023-01-24T09:16:29Z
date_updated: 2023-01-24T09:16:29Z
file_id: '12352'
file_name: 2022_FrontiersNeuroscience_Basilico.pdf
file_size: 6399987
relation: main_file
success: 1
file_date_updated: 2023-01-24T09:16:29Z
has_accepted_license: '1'
intvolume: ' 16'
isi: 1
keyword:
- Cellular and Molecular Neuroscience
language:
- iso: eng
month: '11'
oa: 1
oa_version: Published Version
pmid: 1
publication: Frontiers in Cellular Neuroscience
publication_identifier:
issn:
- 1662-5102
publication_status: published
publisher: Frontiers Media
quality_controlled: '1'
scopus_import: '1'
status: public
title: What microglia depletion approaches tell us about the role of microglia on
synaptic function and behavior
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 16
year: '2022'
...
---
_id: '12142'
abstract:
- lang: eng
text: Theory for liability-scale models of the underlying genetic basis of complex
disease provides an important way to interpret, compare, and understand results
generated from biological studies. In particular, through estimation of the liability-scale
heritability (LSH), liability models facilitate an understanding and comparison
of the relative importance of genetic and environmental risk factors that shape
different clinically important disease outcomes. Increasingly, large-scale biobank
studies that link genetic information to electronic health records, containing
hundreds of disease diagnosis indicators that mostly occur infrequently within
the sample, are becoming available. Here, we propose an extension of the existing
liability-scale model theory suitable for estimating LSH in biobank studies of
low-prevalence disease. In a simulation study, we find that our derived expression
yields lower mean square error (MSE) and is less sensitive to prevalence misspecification
as compared to previous transformations for diseases with =< 2% population prevalence
and LSH of =< 0.45, especially if the biobank sample prevalence is less than that
of the wider population. Applying our expression to 13 diagnostic outcomes of =<
3% prevalence in the UK Biobank study revealed important differences in LSH obtained
from the different theoretical expressions that impact the conclusions made when
comparing LSH across disease outcomes. This demonstrates the importance of careful
consideration for estimation and prediction of low-prevalence disease outcomes
and facilitates improved inference of the underlying genetic basis of =< 2% population
prevalence diseases, especially where biobank sample ascertainment results in
a healthier sample population.
acknowledged_ssus:
- _id: ScienComp
acknowledgement: This project was funded by an SNSF Eccellenza grant to M.R.R. (PCEGP3-181181),
core funding from the Institute of Science and Technology Austria, and core funding
from the Department of Computational Biology of the University of Lausanne. Z.K.
was funded by the Swiss National Science Foundation (310030-189147). This research
was supported by the Scientific Service Units (SSUs) of IST Austria through resources
provided by Scientific Computing (SciComp). We would like to thank the participants
of the UK Biobank.
article_processing_charge: Yes (via OA deal)
article_type: original
author:
- first_name: Sven E.
full_name: Ojavee, Sven E.
last_name: Ojavee
- first_name: Zoltan
full_name: Kutalik, Zoltan
last_name: Kutalik
- first_name: Matthew Richard
full_name: Robinson, Matthew Richard
id: E5D42276-F5DA-11E9-8E24-6303E6697425
last_name: Robinson
orcid: 0000-0001-8982-8813
citation:
ama: Ojavee SE, Kutalik Z, Robinson MR. Liability-scale heritability estimation
for biobank studies of low-prevalence disease. The American Journal of Human
Genetics. 2022;109(11):2009-2017. doi:10.1016/j.ajhg.2022.09.011
apa: Ojavee, S. E., Kutalik, Z., & Robinson, M. R. (2022). Liability-scale heritability
estimation for biobank studies of low-prevalence disease. The American Journal
of Human Genetics. Elsevier. https://doi.org/10.1016/j.ajhg.2022.09.011
chicago: Ojavee, Sven E., Zoltan Kutalik, and Matthew Richard Robinson. “Liability-Scale
Heritability Estimation for Biobank Studies of Low-Prevalence Disease.” The
American Journal of Human Genetics. Elsevier, 2022. https://doi.org/10.1016/j.ajhg.2022.09.011.
ieee: S. E. Ojavee, Z. Kutalik, and M. R. Robinson, “Liability-scale heritability
estimation for biobank studies of low-prevalence disease,” The American Journal
of Human Genetics, vol. 109, no. 11. Elsevier, pp. 2009–2017, 2022.
ista: Ojavee SE, Kutalik Z, Robinson MR. 2022. Liability-scale heritability estimation
for biobank studies of low-prevalence disease. The American Journal of Human Genetics.
109(11), 2009–2017.
mla: Ojavee, Sven E., et al. “Liability-Scale Heritability Estimation for Biobank
Studies of Low-Prevalence Disease.” The American Journal of Human Genetics,
vol. 109, no. 11, Elsevier, 2022, pp. 2009–17, doi:10.1016/j.ajhg.2022.09.011.
short: S.E. Ojavee, Z. Kutalik, M.R. Robinson, The American Journal of Human Genetics
109 (2022) 2009–2017.
date_created: 2023-01-12T12:05:28Z
date_published: 2022-11-03T00:00:00Z
date_updated: 2023-08-04T08:56:46Z
day: '03'
ddc:
- '570'
department:
- _id: MaRo
doi: 10.1016/j.ajhg.2022.09.011
external_id:
isi:
- '000898683500006'
file:
- access_level: open_access
checksum: 4cd7f12bfe21a8237bb095eedfa26361
content_type: application/pdf
creator: dernst
date_created: 2023-01-24T09:23:01Z
date_updated: 2023-01-24T09:23:01Z
file_id: '12353'
file_name: 2022_AJHG_Ojavee.pdf
file_size: 705195
relation: main_file
success: 1
file_date_updated: 2023-01-24T09:23:01Z
has_accepted_license: '1'
intvolume: ' 109'
isi: 1
issue: '11'
keyword:
- Genetics (clinical)
- Genetics
language:
- iso: eng
month: '11'
oa: 1
oa_version: Published Version
page: 2009-2017
project:
- _id: 9B8D11D6-BA93-11EA-9121-9846C619BF3A
grant_number: PCEGP3_181181
name: Improving estimation and prediction of common complex disease risk
publication: The American Journal of Human Genetics
publication_identifier:
issn:
- 0002-9297
publication_status: published
publisher: Elsevier
quality_controlled: '1'
scopus_import: '1'
status: public
title: Liability-scale heritability estimation for biobank studies of low-prevalence
disease
tmp:
image: /images/cc_by_nc_nd.png
legal_code_url: https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode
name: Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
(CC BY-NC-ND 4.0)
short: CC BY-NC-ND (4.0)
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 109
year: '2022'
...