---
_id: '12083'
abstract:
- lang: eng
  text: We consider the many-body time evolution of weakly interacting bosons in the
    mean field regime for initial coherent states. We show that bounded k-particle
    operators, corresponding to dependent random variables, satisfy both a law of
    large numbers and a central limit theorem.
acknowledgement: S.R. would like to thank Robert Seiringer and Benedikt Stufler for
  helpful discussions. Funding from the European Union’s Horizon 2020 Research and
  Innovation Program under the ERC grant (Grant Agreement No. 694227) and under the
  Marie Skłodowska-Curie grant (Agreement No. 754411) is acknowledged.
article_number: '081902'
article_processing_charge: No
article_type: original
arxiv: 1
author:
- first_name: Simone Anna Elvira
  full_name: Rademacher, Simone Anna Elvira
  id: 856966FE-A408-11E9-977E-802DE6697425
  last_name: Rademacher
  orcid: 0000-0001-5059-4466
citation:
  ama: Rademacher SAE. Dependent random variables in quantum dynamics. <i>Journal
    of Mathematical Physics</i>. 2022;63(8). doi:<a href="https://doi.org/10.1063/5.0086712">10.1063/5.0086712</a>
  apa: Rademacher, S. A. E. (2022). Dependent random variables in quantum dynamics.
    <i>Journal of Mathematical Physics</i>. AIP Publishing. <a href="https://doi.org/10.1063/5.0086712">https://doi.org/10.1063/5.0086712</a>
  chicago: Rademacher, Simone Anna Elvira. “Dependent Random Variables in Quantum
    Dynamics.” <i>Journal of Mathematical Physics</i>. AIP Publishing, 2022. <a href="https://doi.org/10.1063/5.0086712">https://doi.org/10.1063/5.0086712</a>.
  ieee: S. A. E. Rademacher, “Dependent random variables in quantum dynamics,” <i>Journal
    of Mathematical Physics</i>, vol. 63, no. 8. AIP Publishing, 2022.
  ista: Rademacher SAE. 2022. Dependent random variables in quantum dynamics. Journal
    of Mathematical Physics. 63(8), 081902.
  mla: Rademacher, Simone Anna Elvira. “Dependent Random Variables in Quantum Dynamics.”
    <i>Journal of Mathematical Physics</i>, vol. 63, no. 8, 081902, AIP Publishing,
    2022, doi:<a href="https://doi.org/10.1063/5.0086712">10.1063/5.0086712</a>.
  short: S.A.E. Rademacher, Journal of Mathematical Physics 63 (2022).
date_created: 2022-09-11T22:01:56Z
date_published: 2022-08-25T00:00:00Z
date_updated: 2023-08-03T13:57:19Z
day: '25'
ddc:
- '510'
department:
- _id: RoSe
doi: 10.1063/5.0086712
ec_funded: 1
external_id:
  arxiv:
  - '2112.04817'
  isi:
  - '000844402500001'
file:
- access_level: open_access
  checksum: e6fb0cf3f0327739c5e69a2cfc4020eb
  content_type: application/pdf
  creator: dernst
  date_created: 2022-09-12T07:35:34Z
  date_updated: 2022-09-12T07:35:34Z
  file_id: '12089'
  file_name: 2022_JourMathPhysics_Rademacher.pdf
  file_size: 4552261
  relation: main_file
  success: 1
file_date_updated: 2022-09-12T07:35:34Z
has_accepted_license: '1'
intvolume: '        63'
isi: 1
issue: '8'
language:
- iso: eng
license: https://creativecommons.org/licenses/by/4.0/
month: '08'
oa: 1
oa_version: Published Version
project:
- _id: 25C6DC12-B435-11E9-9278-68D0E5697425
  call_identifier: H2020
  grant_number: '694227'
  name: Analysis of quantum many-body systems
- _id: 260C2330-B435-11E9-9278-68D0E5697425
  call_identifier: H2020
  grant_number: '754411'
  name: ISTplus - Postdoctoral Fellowships
publication: Journal of Mathematical Physics
publication_identifier:
  issn:
  - 0022-2488
publication_status: published
publisher: AIP Publishing
quality_controlled: '1'
scopus_import: '1'
status: public
title: Dependent random variables in quantum dynamics
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 63
year: '2022'
...
---
_id: '12084'
abstract:
- lang: eng
  text: Neuronal networks encode information through patterns of activity that define
    the networks’ function. The neurons’ activity relies on specific connectivity
    structures, yet the link between structure and function is not fully understood.
    Here, we tackle this structure-function problem with a new conceptual approach.
    Instead of manipulating the connectivity directly, we focus on upper triangular
    matrices, which represent the network dynamics in a given orthonormal basis obtained
    by the Schur decomposition. This abstraction allows us to independently manipulate
    the eigenspectrum and feedforward structures of a connectivity matrix. Using this
    method, we describe a diverse repertoire of non-normal transient amplification,
    and to complement the analysis of the dynamical regimes, we quantify the geometry
    of output trajectories through the effective rank of both the eigenvector and
    the dynamics matrices. Counter-intuitively, we find that shrinking the eigenspectrum’s
    imaginary distribution leads to highly amplifying regimes in linear and long-lasting
    dynamics in nonlinear networks. We also find a trade-off between amplification
    and dimensionality of neuronal dynamics, i.e., trajectories in neuronal state-space.
    Networks that can amplify a large number of orthogonal initial conditions produce
    neuronal trajectories that lie in the same subspace of the neuronal state-space.
    Finally, we examine networks of excitatory and inhibitory neurons. We find that
    the strength of global inhibition is directly linked with the amplitude of amplification,
    such that weakening inhibitory weights also decreases amplification, and that
    the eigenspectrum’s imaginary distribution grows with an increase in the ratio
    between excitatory-to-inhibitory and excitatory-to-excitatory connectivity strengths.
    Consequently, the strength of global inhibition reveals itself as a strong signature
    for amplification and a potential control mechanism to switch dynamical regimes.
    Our results shed a light on how biological networks, i.e., networks constrained
    by Dale’s law, may be optimised for specific dynamical regimes.
acknowledgement: 'We thank Friedemann Zenke for his comments, especially on the effect
  of the self loops on the spectrum. We also thank Ken Miller and Bill Podlaski for
  helpful comments. This research was funded by a Wellcome Trust and Royal Society
  Henry Dale Research Fellowship (WT100000; TPV), a Wellcome Senior Research Fellowship
  (214316/Z/18/Z; GC, EJA, and TPV), and a Research Project Grant by the Leverhulme
  Trust (RPG-2016-446; EJA and TPV). '
article_number: e1010365
article_processing_charge: No
article_type: original
author:
- first_name: Georgia
  full_name: Christodoulou, Georgia
  last_name: Christodoulou
- first_name: Tim P
  full_name: Vogels, Tim P
  id: CB6FF8D2-008F-11EA-8E08-2637E6697425
  last_name: Vogels
  orcid: 0000-0003-3295-6181
- first_name: Everton J.
  full_name: Agnes, Everton J.
  last_name: Agnes
citation:
  ama: Christodoulou G, Vogels TP, Agnes EJ. Regimes and mechanisms of transient amplification
    in abstract and biological neural networks. <i>PLoS Computational Biology</i>.
    2022;18(8). doi:<a href="https://doi.org/10.1371/journal.pcbi.1010365">10.1371/journal.pcbi.1010365</a>
  apa: Christodoulou, G., Vogels, T. P., &#38; Agnes, E. J. (2022). Regimes and mechanisms
    of transient amplification in abstract and biological neural networks. <i>PLoS
    Computational Biology</i>. Public Library of Science. <a href="https://doi.org/10.1371/journal.pcbi.1010365">https://doi.org/10.1371/journal.pcbi.1010365</a>
  chicago: Christodoulou, Georgia, Tim P Vogels, and Everton J. Agnes. “Regimes and
    Mechanisms of Transient Amplification in Abstract and Biological Neural Networks.”
    <i>PLoS Computational Biology</i>. Public Library of Science, 2022. <a href="https://doi.org/10.1371/journal.pcbi.1010365">https://doi.org/10.1371/journal.pcbi.1010365</a>.
  ieee: G. Christodoulou, T. P. Vogels, and E. J. Agnes, “Regimes and mechanisms of
    transient amplification in abstract and biological neural networks,” <i>PLoS Computational
    Biology</i>, vol. 18, no. 8. Public Library of Science, 2022.
  ista: Christodoulou G, Vogels TP, Agnes EJ. 2022. Regimes and mechanisms of transient
    amplification in abstract and biological neural networks. PLoS Computational Biology.
    18(8), e1010365.
  mla: Christodoulou, Georgia, et al. “Regimes and Mechanisms of Transient Amplification
    in Abstract and Biological Neural Networks.” <i>PLoS Computational Biology</i>,
    vol. 18, no. 8, e1010365, Public Library of Science, 2022, doi:<a href="https://doi.org/10.1371/journal.pcbi.1010365">10.1371/journal.pcbi.1010365</a>.
  short: G. Christodoulou, T.P. Vogels, E.J. Agnes, PLoS Computational Biology 18
    (2022).
date_created: 2022-09-11T22:01:56Z
date_published: 2022-08-15T00:00:00Z
date_updated: 2023-08-03T14:06:29Z
day: '15'
ddc:
- '570'
department:
- _id: TiVo
doi: 10.1371/journal.pcbi.1010365
external_id:
  isi:
  - '000937227700001'
file:
- access_level: open_access
  checksum: 8a81ab29f837991ee0ea770817c4a50e
  content_type: application/pdf
  creator: dernst
  date_created: 2022-09-12T07:47:55Z
  date_updated: 2022-09-12T07:47:55Z
  file_id: '12090'
  file_name: 2022_PLoSCompBio_Christodoulou.pdf
  file_size: 2867337
  relation: main_file
  success: 1
file_date_updated: 2022-09-12T07:47:55Z
has_accepted_license: '1'
intvolume: '        18'
isi: 1
issue: '8'
language:
- iso: eng
month: '08'
oa: 1
oa_version: Published Version
project:
- _id: c084a126-5a5b-11eb-8a69-d75314a70a87
  grant_number: 214316/Z/18/Z
  name: What’s in a memory? Spatiotemporal dynamics in strongly coupled recurrent
    neuronal networks.
publication: PLoS Computational Biology
publication_identifier:
  eissn:
  - 1553-7358
publication_status: published
publisher: Public Library of Science
quality_controlled: '1'
scopus_import: '1'
status: public
title: Regimes and mechanisms of transient amplification in abstract and biological
  neural networks
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 18
year: '2022'
...
---
_id: '12085'
abstract:
- lang: eng
  text: Molecular catch bonds are ubiquitous in biology and essential for processes
    like leucocyte extravasion1 and cellular mechanosensing2. Unlike normal (slip)
    bonds, catch bonds strengthen under tension. The current paradigm is that this
    feature provides ‘strength on demand3’, thus enabling cells to increase rigidity
    under stress1,4,5,6. However, catch bonds are often weaker than slip bonds because
    they have cryptic binding sites that are usually buried7,8. Here we show that
    catch bonds render reconstituted cytoskeletal actin networks stronger than slip
    bonds, even though the individual bonds are weaker. Simulations show that slip
    bonds remain trapped in stress-free areas, whereas weak binding allows catch bonds
    to mitigate crack initiation by moving to high-tension areas. This ‘dissociation
    on demand’ explains how cells combine mechanical strength with the adaptability
    required for shape change, and is relevant to diseases where catch bonding is
    compromised7,9, including focal segmental glomerulosclerosis10 caused by the α-actinin-4
    mutant studied here. We surmise that catch bonds are the key to create life-like
    materials.
acknowledgement: 'We thank M. van Hecke and C. Alkemade for critical reading of the
  manuscript. We thank P. R. ten Wolde, K. Storm, W. Ellenbroek, C. Broedersz, D.
  Brueckner and M. Berger for fruitful discussions. We thank W. Brieher and V. Tang
  from the University of Illinois for the kind gift of purified α-actinin-4 (WT and
  the K255E point mutant) and their plasmids; M. Kuit-Vinkenoog and J. den Haan for
  actin and further purification of α-actinin-4; A. Goutou and I. Isturiz-Petitjean
  for co-sedimentation measurements and V. Sunderlíková for the design, mutagenesis,
  cloning and purifying of the α-actinin-4 constructs used in the single-molecule
  experiments. We gratefully acknowledge financial support from the following sources:
  research program of the Netherlands Organization for Scientific Research (NWO) (S.J.T.,
  A.R. and M.J.A.); ERC Starting Grant (335672-MINICELL) (G.H.K. and Y.M.). ‘BaSyC—Building
  a Synthetic Cell’ Gravitation grant (024.003.019) of the Netherlands Ministry of
  Education, Culture and Science (OCW) and the Netherlands Organisation for Scientific
  Research (G.H.K. and L.B.); and support from the National Institutes of Health (1R01GM126256)
  (T.K. and W.J.).'
article_processing_charge: No
article_type: original
author:
- first_name: Yuval
  full_name: Mulla, Yuval
  last_name: Mulla
- first_name: Mario
  full_name: Avellaneda Sarrió, Mario
  id: DC4BA84C-56E6-11EA-AD5D-348C3DDC885E
  last_name: Avellaneda Sarrió
  orcid: 0000-0001-6406-524X
- first_name: Antoine
  full_name: Roland, Antoine
  last_name: Roland
- first_name: Lucia
  full_name: Baldauf, Lucia
  last_name: Baldauf
- first_name: Wonyeong
  full_name: Jung, Wonyeong
  last_name: Jung
- first_name: Taeyoon
  full_name: Kim, Taeyoon
  last_name: Kim
- first_name: Sander J.
  full_name: Tans, Sander J.
  last_name: Tans
- first_name: Gijsje H.
  full_name: Koenderink, Gijsje H.
  last_name: Koenderink
citation:
  ama: Mulla Y, Avellaneda Sarrió M, Roland A, et al. Weak catch bonds make strong
    networks. <i>Nature Materials</i>. 2022;21(9):1019-1023. doi:<a href="https://doi.org/10.1038/s41563-022-01288-0">10.1038/s41563-022-01288-0</a>
  apa: Mulla, Y., Avellaneda Sarrió, M., Roland, A., Baldauf, L., Jung, W., Kim, T.,
    … Koenderink, G. H. (2022). Weak catch bonds make strong networks. <i>Nature Materials</i>.
    Springer Nature. <a href="https://doi.org/10.1038/s41563-022-01288-0">https://doi.org/10.1038/s41563-022-01288-0</a>
  chicago: Mulla, Yuval, Mario Avellaneda Sarrió, Antoine Roland, Lucia Baldauf, Wonyeong
    Jung, Taeyoon Kim, Sander J. Tans, and Gijsje H. Koenderink. “Weak Catch Bonds
    Make Strong Networks.” <i>Nature Materials</i>. Springer Nature, 2022. <a href="https://doi.org/10.1038/s41563-022-01288-0">https://doi.org/10.1038/s41563-022-01288-0</a>.
  ieee: Y. Mulla <i>et al.</i>, “Weak catch bonds make strong networks,” <i>Nature
    Materials</i>, vol. 21, no. 9. Springer Nature, pp. 1019–1023, 2022.
  ista: Mulla Y, Avellaneda Sarrió M, Roland A, Baldauf L, Jung W, Kim T, Tans SJ,
    Koenderink GH. 2022. Weak catch bonds make strong networks. Nature Materials.
    21(9), 1019–1023.
  mla: Mulla, Yuval, et al. “Weak Catch Bonds Make Strong Networks.” <i>Nature Materials</i>,
    vol. 21, no. 9, Springer Nature, 2022, pp. 1019–23, doi:<a href="https://doi.org/10.1038/s41563-022-01288-0">10.1038/s41563-022-01288-0</a>.
  short: Y. Mulla, M. Avellaneda Sarrió, A. Roland, L. Baldauf, W. Jung, T. Kim, S.J.
    Tans, G.H. Koenderink, Nature Materials 21 (2022) 1019–1023.
date_created: 2022-09-11T22:01:57Z
date_published: 2022-09-01T00:00:00Z
date_updated: 2023-08-03T14:08:47Z
day: '01'
department:
- _id: MiSi
doi: 10.1038/s41563-022-01288-0
external_id:
  isi:
  - '000844592000002'
  pmid:
  - '36008604'
intvolume: '        21'
isi: 1
issue: '9'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://doi.org/10.1101/2020.07.27.219618
month: '09'
oa: 1
oa_version: Preprint
page: 1019-1023
pmid: 1
publication: Nature Materials
publication_identifier:
  eissn:
  - 1476-4660
  issn:
  - 1476-1122
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
scopus_import: '1'
status: public
title: Weak catch bonds make strong networks
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 21
year: '2022'
...
---
_id: '12088'
abstract:
- lang: eng
  text: We present a quantum-enabled microwave-telecom interface with bidirectional
    conversion efficiencies up to 15% and added input noise quanta as low as 0.16.
    Moreover, we observe evidence for electro-optic laser cooling and vacuum amplification.
article_number: FW4D.4
article_processing_charge: No
author:
- first_name: Rishabh
  full_name: Sahu, Rishabh
  id: 47D26E34-F248-11E8-B48F-1D18A9856A87
  last_name: Sahu
  orcid: 0000-0001-6264-2162
- first_name: William J
  full_name: Hease, William J
  id: 29705398-F248-11E8-B48F-1D18A9856A87
  last_name: Hease
- first_name: Alfredo R
  full_name: Rueda Sanchez, Alfredo R
  id: 3B82B0F8-F248-11E8-B48F-1D18A9856A87
  last_name: Rueda Sanchez
  orcid: 0000-0001-6249-5860
- first_name: Georg M
  full_name: Arnold, Georg M
  id: 3770C838-F248-11E8-B48F-1D18A9856A87
  last_name: Arnold
- first_name: Liu
  full_name: Qiu, Liu
  id: 45e99c0d-1eb1-11eb-9b96-ed8ab2983cac
  last_name: Qiu
  orcid: 0000-0003-4345-4267
- first_name: Johannes M
  full_name: Fink, Johannes M
  id: 4B591CBA-F248-11E8-B48F-1D18A9856A87
  last_name: Fink
  orcid: 0000-0001-8112-028X
citation:
  ama: 'Sahu R, Hease WJ, Rueda Sanchez AR, Arnold GM, Qiu L, Fink JM. Realizing a
    quantum-enabled interconnect between microwave and telecom light. In: <i>Conference
    on Lasers and Electro-Optics</i>. Optica Publishing Group; 2022. doi:<a href="https://doi.org/10.1364/CLEO_QELS.2022.FW4D.4">10.1364/CLEO_QELS.2022.FW4D.4</a>'
  apa: 'Sahu, R., Hease, W. J., Rueda Sanchez, A. R., Arnold, G. M., Qiu, L., &#38;
    Fink, J. M. (2022). Realizing a quantum-enabled interconnect between microwave
    and telecom light. In <i>Conference on Lasers and Electro-Optics</i>. San Jose,
    CA, United States: Optica Publishing Group. <a href="https://doi.org/10.1364/CLEO_QELS.2022.FW4D.4">https://doi.org/10.1364/CLEO_QELS.2022.FW4D.4</a>'
  chicago: Sahu, Rishabh, William J Hease, Alfredo R Rueda Sanchez, Georg M Arnold,
    Liu Qiu, and Johannes M Fink. “Realizing a Quantum-Enabled Interconnect between
    Microwave and Telecom Light.” In <i>Conference on Lasers and Electro-Optics</i>.
    Optica Publishing Group, 2022. <a href="https://doi.org/10.1364/CLEO_QELS.2022.FW4D.4">https://doi.org/10.1364/CLEO_QELS.2022.FW4D.4</a>.
  ieee: R. Sahu, W. J. Hease, A. R. Rueda Sanchez, G. M. Arnold, L. Qiu, and J. M.
    Fink, “Realizing a quantum-enabled interconnect between microwave and telecom
    light,” in <i>Conference on Lasers and Electro-Optics</i>, San Jose, CA, United
    States, 2022.
  ista: 'Sahu R, Hease WJ, Rueda Sanchez AR, Arnold GM, Qiu L, Fink JM. 2022. Realizing
    a quantum-enabled interconnect between microwave and telecom light. Conference
    on Lasers and Electro-Optics. CLEO: QELS Fundamental Science, FW4D.4.'
  mla: Sahu, Rishabh, et al. “Realizing a Quantum-Enabled Interconnect between Microwave
    and Telecom Light.” <i>Conference on Lasers and Electro-Optics</i>, FW4D.4, Optica
    Publishing Group, 2022, doi:<a href="https://doi.org/10.1364/CLEO_QELS.2022.FW4D.4">10.1364/CLEO_QELS.2022.FW4D.4</a>.
  short: R. Sahu, W.J. Hease, A.R. Rueda Sanchez, G.M. Arnold, L. Qiu, J.M. Fink,
    in:, Conference on Lasers and Electro-Optics, Optica Publishing Group, 2022.
conference:
  end_date: 2022-05-20
  location: San Jose, CA, United States
  name: 'CLEO: QELS Fundamental Science'
  start_date: 2022-05-15
date_created: 2022-09-11T22:01:58Z
date_published: 2022-05-01T00:00:00Z
date_updated: 2023-02-13T09:06:10Z
day: '01'
department:
- _id: JoFi
doi: 10.1364/CLEO_QELS.2022.FW4D.4
language:
- iso: eng
month: '05'
oa_version: None
publication: Conference on Lasers and Electro-Optics
publication_identifier:
  isbn:
  - '9781557528209'
publication_status: published
publisher: Optica Publishing Group
quality_controlled: '1'
scopus_import: '1'
status: public
title: Realizing a quantum-enabled interconnect between microwave and telecom light
type: conference
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '2022'
...
---
_id: '12101'
abstract:
- lang: eng
  text: 'Spatial games form a widely-studied class of games from biology and physics
    modeling the evolution of social behavior. Formally, such a game is defined by
    a square (d by d) payoff matrix M and an undirected graph G. Each vertex of G
    represents an individual, that initially follows some strategy i ∈ {1,2,…,d}.
    In each round of the game, every individual plays the matrix game with each of
    its neighbors: An individual following strategy i meeting a neighbor following
    strategy j receives a payoff equal to the entry (i,j) of M. Then, each individual
    updates its strategy to its neighbors'' strategy with the highest sum of payoffs,
    and the next round starts. The basic computational problems consist of reachability
    between configurations and the average frequency of a strategy. For general spatial
    games and graphs, these problems are in PSPACE. In this paper, we examine restricted
    setting: the game is a prisoner’s dilemma; and G is a subgraph of grid. We prove
    that basic computational problems for spatial games with prisoner’s dilemma on
    a subgraph of a grid are PSPACE-hard.'
acknowledgement: "Krishnendu Chatterjee: The research was partially supported by the
  ERC CoG 863818\r\n(ForM-SMArt).\r\nIsmaël Jecker: The research was partially supported
  by the ERC grant 950398 (INFSYS).\r\nJakub Svoboda: The research was partially supported
  by the ERC CoG 863818 (ForM-SMArt)"
article_number: 11:1-11:14
article_processing_charge: No
author:
- first_name: Krishnendu
  full_name: Chatterjee, Krishnendu
  id: 2E5DCA20-F248-11E8-B48F-1D18A9856A87
  last_name: Chatterjee
  orcid: 0000-0002-4561-241X
- first_name: Rasmus
  full_name: Ibsen-Jensen, Rasmus
  id: 3B699956-F248-11E8-B48F-1D18A9856A87
  last_name: Ibsen-Jensen
  orcid: 0000-0003-4783-0389
- first_name: Ismael R
  full_name: Jecker, Ismael R
  id: 85D7C63E-7D5D-11E9-9C0F-98C4E5697425
  last_name: Jecker
- first_name: Jakub
  full_name: Svoboda, Jakub
  id: 130759D2-D7DD-11E9-87D2-DE0DE6697425
  last_name: Svoboda
  orcid: 0000-0002-1419-3267
citation:
  ama: 'Chatterjee K, Ibsen-Jensen R, Jecker IR, Svoboda J. Complexity of spatial
    games. In: <i>42nd IARCS Annual Conference on Foundations of Software Technology
    and Theoretical Computer Science</i>. Vol 250. Schloss Dagstuhl - Leibniz-Zentrum
    für Informatik; 2022. doi:<a href="https://doi.org/10.4230/LIPIcs.FSTTCS.2022.11">10.4230/LIPIcs.FSTTCS.2022.11</a>'
  apa: 'Chatterjee, K., Ibsen-Jensen, R., Jecker, I. R., &#38; Svoboda, J. (2022).
    Complexity of spatial games. In <i>42nd IARCS Annual Conference on Foundations
    of Software Technology and Theoretical Computer Science</i> (Vol. 250). Madras,
    India: Schloss Dagstuhl - Leibniz-Zentrum für Informatik. <a href="https://doi.org/10.4230/LIPIcs.FSTTCS.2022.11">https://doi.org/10.4230/LIPIcs.FSTTCS.2022.11</a>'
  chicago: Chatterjee, Krishnendu, Rasmus Ibsen-Jensen, Ismael R Jecker, and Jakub
    Svoboda. “Complexity of Spatial Games.” In <i>42nd IARCS Annual Conference on
    Foundations of Software Technology and Theoretical Computer Science</i>, Vol.
    250. Schloss Dagstuhl - Leibniz-Zentrum für Informatik, 2022. <a href="https://doi.org/10.4230/LIPIcs.FSTTCS.2022.11">https://doi.org/10.4230/LIPIcs.FSTTCS.2022.11</a>.
  ieee: K. Chatterjee, R. Ibsen-Jensen, I. R. Jecker, and J. Svoboda, “Complexity
    of spatial games,” in <i>42nd IARCS Annual Conference on Foundations of Software
    Technology and Theoretical Computer Science</i>, Madras, India, 2022, vol. 250.
  ista: 'Chatterjee K, Ibsen-Jensen R, Jecker IR, Svoboda J. 2022. Complexity of spatial
    games. 42nd IARCS Annual Conference on Foundations of Software Technology and
    Theoretical Computer Science. FSTTC: Foundations of Software Technology and Theoretical
    Computer Science vol. 250, 11:1-11:14.'
  mla: Chatterjee, Krishnendu, et al. “Complexity of Spatial Games.” <i>42nd IARCS
    Annual Conference on Foundations of Software Technology and Theoretical Computer
    Science</i>, vol. 250, 11:1-11:14, Schloss Dagstuhl - Leibniz-Zentrum für Informatik,
    2022, doi:<a href="https://doi.org/10.4230/LIPIcs.FSTTCS.2022.11">10.4230/LIPIcs.FSTTCS.2022.11</a>.
  short: K. Chatterjee, R. Ibsen-Jensen, I.R. Jecker, J. Svoboda, in:, 42nd IARCS
    Annual Conference on Foundations of Software Technology and Theoretical Computer
    Science, Schloss Dagstuhl - Leibniz-Zentrum für Informatik, 2022.
conference:
  end_date: 2022-12-20
  location: Madras, India
  name: 'FSTTC: Foundations of Software Technology and Theoretical Computer Science'
  start_date: 2022-12-18
date_created: 2023-01-01T23:00:50Z
date_published: 2022-12-14T00:00:00Z
date_updated: 2025-07-14T09:09:55Z
day: '14'
ddc:
- '000'
department:
- _id: KrCh
doi: 10.4230/LIPIcs.FSTTCS.2022.11
ec_funded: 1
file:
- access_level: open_access
  checksum: a21e3ba2421e2c4a06aa2cb6d530ede1
  content_type: application/pdf
  creator: dernst
  date_created: 2023-01-20T10:19:19Z
  date_updated: 2023-01-20T10:19:19Z
  file_id: '12323'
  file_name: 2022_LIPICs_Chatterjee.pdf
  file_size: 657396
  relation: main_file
  success: 1
file_date_updated: 2023-01-20T10:19:19Z
has_accepted_license: '1'
intvolume: '       250'
language:
- iso: eng
month: '12'
oa: 1
oa_version: Published Version
project:
- _id: 0599E47C-7A3F-11EA-A408-12923DDC885E
  call_identifier: H2020
  grant_number: '863818'
  name: 'Formal Methods for Stochastic Models: Algorithms and Applications'
publication: 42nd IARCS Annual Conference on Foundations of Software Technology and
  Theoretical Computer Science
publication_identifier:
  isbn:
  - '9783959772617'
  issn:
  - 1868-8969
publication_status: published
publisher: Schloss Dagstuhl - Leibniz-Zentrum für Informatik
quality_controlled: '1'
scopus_import: '1'
status: public
title: Complexity of spatial games
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: conference
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 250
year: '2022'
...
---
_id: '12102'
abstract:
- lang: eng
  text: 'Given a Markov chain M = (V, v_0, δ), with state space V and a starting state
    v_0, and a probability threshold ε, an ε-core is a subset C of states that is
    left with probability at most ε. More formally, C ⊆ V is an ε-core, iff ℙ[reach
    (V\C)] ≤ ε. Cores have been applied in a wide variety of verification problems
    over Markov chains, Markov decision processes, and probabilistic programs, as
    a means of discarding uninteresting and low-probability parts of a probabilistic
    system and instead being able to focus on the states that are likely to be encountered
    in a real-world run. In this work, we focus on the problem of computing a minimal
    ε-core in a Markov chain. Our contributions include both negative and positive
    results: (i) We show that the decision problem on the existence of an ε-core of
    a given size is NP-complete. This solves an open problem posed in [Jan Kretínský
    and Tobias Meggendorfer, 2020]. We additionally show that the problem remains
    NP-complete even when limited to acyclic Markov chains with bounded maximal vertex
    degree; (ii) We provide a polynomial time algorithm for computing a minimal ε-core
    on Markov chains over control-flow graphs of structured programs. A straightforward
    combination of our algorithm with standard branch prediction techniques allows
    one to apply the idea of cores to find a subset of program lines that are left
    with low probability and then focus any desired static analysis on this core subset.'
acknowledgement: "The research was partially supported by the Hong Kong Research Grants
  Council ECS\r\nProject No. 26208122, ERC CoG 863818 (FoRM-SMArt), the European Union’s
  Horizon 2020 research and innovation programme under the Marie Skłodowska-Curie
  Grant Agreement No. 665385, HKUST– Kaisa Joint Research Institute Project Grant
  HKJRI3A-055 and HKUST Startup Grant R9272. Ali Ahmadi and Roodabeh Safavi were interns
  at HKUST."
article_number: '29'
article_processing_charge: No
author:
- first_name: Ali
  full_name: Ahmadi, Ali
  last_name: Ahmadi
- first_name: Krishnendu
  full_name: Chatterjee, Krishnendu
  id: 2E5DCA20-F248-11E8-B48F-1D18A9856A87
  last_name: Chatterjee
  orcid: 0000-0002-4561-241X
- first_name: Amir Kafshdar
  full_name: Goharshady, Amir Kafshdar
  id: 391365CE-F248-11E8-B48F-1D18A9856A87
  last_name: Goharshady
  orcid: 0000-0003-1702-6584
- first_name: Tobias
  full_name: Meggendorfer, Tobias
  id: b21b0c15-30a2-11eb-80dc-f13ca25802e1
  last_name: Meggendorfer
  orcid: 0000-0002-1712-2165
- first_name: Roodabeh
  full_name: Safavi Hemami, Roodabeh
  id: 72ed2640-8972-11ed-ae7b-f9c81ec75154
  last_name: Safavi Hemami
- first_name: Dorde
  full_name: Zikelic, Dorde
  id: 294AA7A6-F248-11E8-B48F-1D18A9856A87
  last_name: Zikelic
  orcid: 0000-0002-4681-1699
citation:
  ama: 'Ahmadi A, Chatterjee K, Goharshady AK, Meggendorfer T, Safavi Hemami R, Zikelic
    D. Algorithms and hardness results for computing cores of Markov chains. In: <i>42nd
    IARCS Annual Conference on Foundations of Software Technology and Theoretical
    Computer Science</i>. Vol 250. Schloss Dagstuhl - Leibniz-Zentrum für Informatik;
    2022. doi:<a href="https://doi.org/10.4230/LIPIcs.FSTTCS.2022.29">10.4230/LIPIcs.FSTTCS.2022.29</a>'
  apa: 'Ahmadi, A., Chatterjee, K., Goharshady, A. K., Meggendorfer, T., Safavi Hemami,
    R., &#38; Zikelic, D. (2022). Algorithms and hardness results for computing cores
    of Markov chains. In <i>42nd IARCS Annual Conference on Foundations of Software
    Technology and Theoretical Computer Science</i> (Vol. 250). Madras, India: Schloss
    Dagstuhl - Leibniz-Zentrum für Informatik. <a href="https://doi.org/10.4230/LIPIcs.FSTTCS.2022.29">https://doi.org/10.4230/LIPIcs.FSTTCS.2022.29</a>'
  chicago: Ahmadi, Ali, Krishnendu Chatterjee, Amir Kafshdar Goharshady, Tobias Meggendorfer,
    Roodabeh Safavi Hemami, and Dorde Zikelic. “Algorithms and Hardness Results for
    Computing Cores of Markov Chains.” In <i>42nd IARCS Annual Conference on Foundations
    of Software Technology and Theoretical Computer Science</i>, Vol. 250. Schloss
    Dagstuhl - Leibniz-Zentrum für Informatik, 2022. <a href="https://doi.org/10.4230/LIPIcs.FSTTCS.2022.29">https://doi.org/10.4230/LIPIcs.FSTTCS.2022.29</a>.
  ieee: A. Ahmadi, K. Chatterjee, A. K. Goharshady, T. Meggendorfer, R. Safavi Hemami,
    and D. Zikelic, “Algorithms and hardness results for computing cores of Markov
    chains,” in <i>42nd IARCS Annual Conference on Foundations of Software Technology
    and Theoretical Computer Science</i>, Madras, India, 2022, vol. 250.
  ista: 'Ahmadi A, Chatterjee K, Goharshady AK, Meggendorfer T, Safavi Hemami R, Zikelic
    D. 2022. Algorithms and hardness results for computing cores of Markov chains.
    42nd IARCS Annual Conference on Foundations of Software Technology and Theoretical
    Computer Science. FSTTC: Foundations of Software Technology and Theoretical Computer
    Science vol. 250, 29.'
  mla: Ahmadi, Ali, et al. “Algorithms and Hardness Results for Computing Cores of
    Markov Chains.” <i>42nd IARCS Annual Conference on Foundations of Software Technology
    and Theoretical Computer Science</i>, vol. 250, 29, Schloss Dagstuhl - Leibniz-Zentrum
    für Informatik, 2022, doi:<a href="https://doi.org/10.4230/LIPIcs.FSTTCS.2022.29">10.4230/LIPIcs.FSTTCS.2022.29</a>.
  short: A. Ahmadi, K. Chatterjee, A.K. Goharshady, T. Meggendorfer, R. Safavi Hemami,
    D. Zikelic, in:, 42nd IARCS Annual Conference on Foundations of Software Technology
    and Theoretical Computer Science, Schloss Dagstuhl - Leibniz-Zentrum für Informatik,
    2022.
conference:
  end_date: 2022-12-20
  location: Madras, India
  name: 'FSTTC: Foundations of Software Technology and Theoretical Computer Science'
  start_date: 2022-12-18
date_created: 2023-01-01T23:00:50Z
date_published: 2022-12-14T00:00:00Z
date_updated: 2025-07-14T09:09:55Z
day: '14'
ddc:
- '000'
department:
- _id: KrCh
- _id: GradSch
doi: 10.4230/LIPIcs.FSTTCS.2022.29
ec_funded: 1
file:
- access_level: open_access
  checksum: 6660c802489013f034c9e8bd57f4d46e
  content_type: application/pdf
  creator: dernst
  date_created: 2023-01-20T10:39:44Z
  date_updated: 2023-01-20T10:39:44Z
  file_id: '12324'
  file_name: 2022_LIPICs_Ahmadi.pdf
  file_size: 872534
  relation: main_file
  success: 1
file_date_updated: 2023-01-20T10:39:44Z
has_accepted_license: '1'
intvolume: '       250'
language:
- iso: eng
month: '12'
oa: 1
oa_version: Published Version
project:
- _id: 0599E47C-7A3F-11EA-A408-12923DDC885E
  call_identifier: H2020
  grant_number: '863818'
  name: 'Formal Methods for Stochastic Models: Algorithms and Applications'
- _id: 2564DBCA-B435-11E9-9278-68D0E5697425
  call_identifier: H2020
  grant_number: '665385'
  name: International IST Doctoral Program
publication: 42nd IARCS Annual Conference on Foundations of Software Technology and
  Theoretical Computer Science
publication_identifier:
  isbn:
  - '9783959772617'
  issn:
  - 1868-8969
publication_status: published
publisher: Schloss Dagstuhl - Leibniz-Zentrum für Informatik
quality_controlled: '1'
scopus_import: '1'
status: public
title: Algorithms and hardness results for computing cores of Markov chains
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: conference
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 250
year: '2022'
...
---
_id: '12107'
abstract:
- lang: eng
  text: The sensitivity of coarse-grained daily extreme precipitation to sea surface
    temperature is analyzed using satellite precipitation estimates over the 300–302.5
    K range. A theoretical scaling is proposed, linking changes in coarse-grained
    precipitation to changes in fine-scale hourly precipitation area fraction and
    changes in conditional fine-scale precipitation rates. The analysis reveals that
    the extreme coarse-grained precipitation scaling with temperature (∼7%/K) is dominated
    by the fine-scale precipitating fraction scaling (∼6.5%/K) when using a 3 mm/h
    fine-scale threshold to delineate the precipitating fraction. These results are
    shown to be robust to the selection of the precipitation product and to the percentile
    used to characterize the extreme. This new coarse-grained scaling is further related
    to the well-known scaling for fine-scale precipitation extremes, and suggests
    a compensation between thermodynamic and dynamic contributions or that both contributions
    are small with respect to that of fractional coverage. These results suggest that
    processes responsible for the changes in fractional coverage are to be accounted
    for to assess the sensitivity of coarse-grained extreme daily precipitation to
    surface temperature.
acknowledgement: "We thank S. Cloché for her support with the handling of these various
  data sets. This study benefited from the IPSL mesocenter ESPRI facility which is
  supported by CNRS, UPMC, Labex L-IPSL, CNES and Ecole Polytechnique. We thank Rômulo
  A. Jucá Oliveira and Thomas\r\nFiolleau for helpful discussions on satellite data
  and precipitation. The authors acknowledge the CNES and CNRS support under the Megha-Tropiques
  program. C.M. gratefully acknowledges\r\nfunding from the European Research Council
  (ERC) under the European Union's Horizon 2020 research and innovation programme
  (Project CLUSTER, Grant agreement 805041). We further\r\nthank the reviewers for
  their insightful comments that improved the paper."
article_number: e2022GL100624
article_processing_charge: No
article_type: letter_note
author:
- first_name: Rémy
  full_name: Roca, Rémy
  last_name: Roca
- first_name: Victorien
  full_name: De Meyer, Victorien
  last_name: De Meyer
- first_name: Caroline J
  full_name: Muller, Caroline J
  id: f978ccb0-3f7f-11eb-b193-b0e2bd13182b
  last_name: Muller
  orcid: 0000-0001-5836-5350
citation:
  ama: Roca R, De Meyer V, Muller CJ. Precipitating fraction, not intensity, explains
    extreme coarse-grained precipitation Clausius-Clapeyron scaling with sea surface
    temperature over tropical oceans. <i>Geophysical Research Letters</i>. 2022;49(24).
    doi:<a href="https://doi.org/10.1029/2022GL100624">10.1029/2022GL100624</a>
  apa: Roca, R., De Meyer, V., &#38; Muller, C. J. (2022). Precipitating fraction,
    not intensity, explains extreme coarse-grained precipitation Clausius-Clapeyron
    scaling with sea surface temperature over tropical oceans. <i>Geophysical Research
    Letters</i>. Wiley. <a href="https://doi.org/10.1029/2022GL100624">https://doi.org/10.1029/2022GL100624</a>
  chicago: Roca, Rémy, Victorien De Meyer, and Caroline J Muller. “Precipitating Fraction,
    Not Intensity, Explains Extreme Coarse-Grained Precipitation Clausius-Clapeyron
    Scaling with Sea Surface Temperature over Tropical Oceans.” <i>Geophysical Research
    Letters</i>. Wiley, 2022. <a href="https://doi.org/10.1029/2022GL100624">https://doi.org/10.1029/2022GL100624</a>.
  ieee: R. Roca, V. De Meyer, and C. J. Muller, “Precipitating fraction, not intensity,
    explains extreme coarse-grained precipitation Clausius-Clapeyron scaling with
    sea surface temperature over tropical oceans,” <i>Geophysical Research Letters</i>,
    vol. 49, no. 24. Wiley, 2022.
  ista: Roca R, De Meyer V, Muller CJ. 2022. Precipitating fraction, not intensity,
    explains extreme coarse-grained precipitation Clausius-Clapeyron scaling with
    sea surface temperature over tropical oceans. Geophysical Research Letters. 49(24),
    e2022GL100624.
  mla: Roca, Rémy, et al. “Precipitating Fraction, Not Intensity, Explains Extreme
    Coarse-Grained Precipitation Clausius-Clapeyron Scaling with Sea Surface Temperature
    over Tropical Oceans.” <i>Geophysical Research Letters</i>, vol. 49, no. 24, e2022GL100624,
    Wiley, 2022, doi:<a href="https://doi.org/10.1029/2022GL100624">10.1029/2022GL100624</a>.
  short: R. Roca, V. De Meyer, C.J. Muller, Geophysical Research Letters 49 (2022).
date_created: 2023-01-08T23:00:53Z
date_published: 2022-12-28T00:00:00Z
date_updated: 2023-08-03T14:10:27Z
day: '28'
ddc:
- '550'
department:
- _id: CaMu
doi: 10.1029/2022GL100624
external_id:
  isi:
  - '000924587900001'
file:
- access_level: open_access
  checksum: 2c6325cea8938adeea7e3a6f5c2ab64e
  content_type: application/pdf
  creator: dernst
  date_created: 2023-01-20T10:52:31Z
  date_updated: 2023-01-20T10:52:31Z
  file_id: '12326'
  file_name: 2022_GeophysicalResearchLetters_Roca.pdf
  file_size: 875379
  relation: main_file
  success: 1
file_date_updated: 2023-01-20T10:52:31Z
has_accepted_license: '1'
intvolume: '        49'
isi: 1
issue: '24'
language:
- iso: eng
license: https://creativecommons.org/licenses/by-nc-nd/4.0/
month: '12'
oa: 1
oa_version: Published Version
publication: Geophysical Research Letters
publication_identifier:
  eissn:
  - 1944-8007
  issn:
  - 0094-8276
publication_status: published
publisher: Wiley
quality_controlled: '1'
scopus_import: '1'
status: public
title: Precipitating fraction, not intensity, explains extreme coarse-grained precipitation
  Clausius-Clapeyron scaling with sea surface temperature over tropical oceans
tmp:
  image: /images/cc_by_nc_nd.png
  legal_code_url: https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode
  name: Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
    (CC BY-NC-ND 4.0)
  short: CC BY-NC-ND (4.0)
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 49
year: '2022'
...
---
_id: '12108'
abstract:
- lang: eng
  text: The sequential exchange of filament composition to increase filament curvature
    was proposed as a mechanism for how some biological polymers deform and cut membranes.
    The relationship between the filament composition and its mechanical effect is
    lacking. We develop a kinetic model for the assembly of composite filaments that
    includes protein–membrane adhesion, filament mechanics and membrane mechanics.
    We identify the physical conditions for such a membrane remodeling and show this
    mechanism of sequential polymer assembly lowers the energetic barrier for membrane
    deformation.
acknowledgement: "We thank T. C. T. Michaels and J. Palacci for useful discussions.
  We thank Claudia Flandoli for the illustrations in Fig. 1(b) and Fig. 2. We acknowledge
  funding by the European Union’s Horizon 2020 Research and Innovation Programme under
  the Marie Skłodowska-Curie Grant\r\nAgreement No. 101034413 (I. P.), the Royal Society
  Grant No. UF160266 (A. Š.), the European Research Council under the European Union’s
  Horizon 2020 Research and Innovation Programme (Grant No. 802960; B. M., I. P.,
  and A. Š.), and the Volkswagen Foundation\r\nLife Grant (B. B. and A. Š). "
article_number: '268101'
article_processing_charge: No
article_type: original
author:
- first_name: Billie
  full_name: Meadowcroft, Billie
  id: a4725fd6-932b-11ed-81e2-c098c7f37ae1
  last_name: Meadowcroft
- first_name: Ivan
  full_name: Palaia, Ivan
  id: 9c805cd2-4b75-11ec-a374-db6dd0ed57fa
  last_name: Palaia
  orcid: ' 0000-0002-8843-9485 '
- first_name: Anna Katharina
  full_name: Pfitzner, Anna Katharina
  last_name: Pfitzner
- first_name: Aurélien
  full_name: Roux, Aurélien
  last_name: Roux
- first_name: Buzz
  full_name: Baum, Buzz
  last_name: Baum
- first_name: Anđela
  full_name: Šarić, Anđela
  id: bf63d406-f056-11eb-b41d-f263a6566d8b
  last_name: Šarić
  orcid: 0000-0002-7854-2139
citation:
  ama: Meadowcroft B, Palaia I, Pfitzner AK, Roux A, Baum B, Šarić A. Mechanochemical
    rules for shape-shifting filaments that remodel membranes. <i>Physical Review
    Letters</i>. 2022;129(26). doi:<a href="https://doi.org/10.1103/PhysRevLett.129.268101">10.1103/PhysRevLett.129.268101</a>
  apa: Meadowcroft, B., Palaia, I., Pfitzner, A. K., Roux, A., Baum, B., &#38; Šarić,
    A. (2022). Mechanochemical rules for shape-shifting filaments that remodel membranes.
    <i>Physical Review Letters</i>. American Physical Society. <a href="https://doi.org/10.1103/PhysRevLett.129.268101">https://doi.org/10.1103/PhysRevLett.129.268101</a>
  chicago: Meadowcroft, Billie, Ivan Palaia, Anna Katharina Pfitzner, Aurélien Roux,
    Buzz Baum, and Anđela Šarić. “Mechanochemical Rules for Shape-Shifting Filaments
    That Remodel Membranes.” <i>Physical Review Letters</i>. American Physical Society,
    2022. <a href="https://doi.org/10.1103/PhysRevLett.129.268101">https://doi.org/10.1103/PhysRevLett.129.268101</a>.
  ieee: B. Meadowcroft, I. Palaia, A. K. Pfitzner, A. Roux, B. Baum, and A. Šarić,
    “Mechanochemical rules for shape-shifting filaments that remodel membranes,” <i>Physical
    Review Letters</i>, vol. 129, no. 26. American Physical Society, 2022.
  ista: Meadowcroft B, Palaia I, Pfitzner AK, Roux A, Baum B, Šarić A. 2022. Mechanochemical
    rules for shape-shifting filaments that remodel membranes. Physical Review Letters.
    129(26), 268101.
  mla: Meadowcroft, Billie, et al. “Mechanochemical Rules for Shape-Shifting Filaments
    That Remodel Membranes.” <i>Physical Review Letters</i>, vol. 129, no. 26, 268101,
    American Physical Society, 2022, doi:<a href="https://doi.org/10.1103/PhysRevLett.129.268101">10.1103/PhysRevLett.129.268101</a>.
  short: B. Meadowcroft, I. Palaia, A.K. Pfitzner, A. Roux, B. Baum, A. Šarić, Physical
    Review Letters 129 (2022).
date_created: 2023-01-08T23:00:53Z
date_published: 2022-12-23T00:00:00Z
date_updated: 2023-08-03T14:10:59Z
day: '23'
department:
- _id: AnSa
doi: 10.1103/PhysRevLett.129.268101
ec_funded: 1
external_id:
  isi:
  - '000906721500001'
  pmid:
  - '36608212'
intvolume: '       129'
isi: 1
issue: '26'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: 'https://doi.org/10.1101/2022.05.10.490642 '
month: '12'
oa: 1
oa_version: Preprint
pmid: 1
project:
- _id: fc2ed2f7-9c52-11eb-aca3-c01059dda49c
  call_identifier: H2020
  grant_number: '101034413'
  name: 'IST-BRIDGE: International postdoctoral program'
- _id: eba2549b-77a9-11ec-83b8-a81e493eae4e
  call_identifier: H2020
  grant_number: '802960'
  name: 'Non-Equilibrium Protein Assembly: from Building Blocks to Biological Machines'
- _id: eba0f67c-77a9-11ec-83b8-cc8501b3e222
  grant_number: '96752'
  name: 'The evolution of trafficking: from archaea to eukaryotes'
publication: Physical Review Letters
publication_identifier:
  eissn:
  - 1079-7114
  issn:
  - 0031-9007
publication_status: published
publisher: American Physical Society
quality_controlled: '1'
scopus_import: '1'
status: public
title: Mechanochemical rules for shape-shifting filaments that remodel membranes
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 129
year: '2022'
...
---
_id: '12109'
abstract:
- lang: eng
  text: Kelvin probe force microscopy (KPFM) is a powerful tool for studying contact
    electrification (CE) at the nanoscale, but converting KPFM voltage maps to charge
    density maps is nontrivial due to long-range forces and complex system geometry.
    Here we present a strategy using finite-element method (FEM) simulations to determine
    the Green's function of the KPFM probe/insulator/ground system, which allows us
    to quantitatively extract surface charge. Testing our approach with synthetic
    data, we find that accounting for the atomic force microscope (AFM) tip, cone,
    and cantilever is necessary to recover a known input and that existing methods
    lead to gross miscalculation or even the incorrect sign of the underlying charge.
    Applying it to experimental data, we demonstrate its capacity to extract realistic
    surface charge densities and fine details from contact-charged surfaces. Our method
    gives a straightforward recipe to convert qualitative KPFM voltage data into quantitative
    charge data over a range of experimental conditions, enabling quantitative CE
    at the nanoscale.
acknowledged_ssus:
- _id: M-Shop
- _id: NanoFab
- _id: ScienComp
acknowledgement: "This project has received funding from the European Research Council
  (ERC) under the European Union’s Horizon 2020 research and innovation programme
  (Grant Agreement\r\nNo. 949120). This research was supported by the Scientific Service
  Units of the Institute of Science and Technology Austria (ISTA) through resources
  provided by the Miba Machine\r\nShop, the Nanofabrication Facility, and the Scientific
  Computing Facility. We thank F. Stumpf from Park Systems for useful discussions
  and support with scanning probe microscopy.\r\nF.P. and J.C.S. contributed equally
  to this work."
article_number: '125605'
article_processing_charge: No
article_type: original
arxiv: 1
author:
- first_name: Felix
  full_name: Pertl, Felix
  id: 6313aec0-15b2-11ec-abd3-ed67d16139af
  last_name: Pertl
- first_name: Juan Carlos A
  full_name: Sobarzo Ponce, Juan Carlos A
  id: 4B807D68-AE37-11E9-AC72-31CAE5697425
  last_name: Sobarzo Ponce
- first_name: Lubuna B
  full_name: Shafeek, Lubuna B
  id: 3CD37A82-F248-11E8-B48F-1D18A9856A87
  last_name: Shafeek
  orcid: 0000-0001-7180-6050
- first_name: Tobias
  full_name: Cramer, Tobias
  last_name: Cramer
- first_name: Scott R
  full_name: Waitukaitis, Scott R
  id: 3A1FFC16-F248-11E8-B48F-1D18A9856A87
  last_name: Waitukaitis
  orcid: 0000-0002-2299-3176
citation:
  ama: Pertl F, Sobarzo Ponce JCA, Shafeek LB, Cramer T, Waitukaitis SR. Quantifying
    nanoscale charge density features of contact-charged surfaces with an FEM/KPFM-hybrid
    approach. <i>Physical Review Materials</i>. 2022;6(12). doi:<a href="https://doi.org/10.1103/PhysRevMaterials.6.125605">10.1103/PhysRevMaterials.6.125605</a>
  apa: Pertl, F., Sobarzo Ponce, J. C. A., Shafeek, L. B., Cramer, T., &#38; Waitukaitis,
    S. R. (2022). Quantifying nanoscale charge density features of contact-charged
    surfaces with an FEM/KPFM-hybrid approach. <i>Physical Review Materials</i>. American
    Physical Society. <a href="https://doi.org/10.1103/PhysRevMaterials.6.125605">https://doi.org/10.1103/PhysRevMaterials.6.125605</a>
  chicago: Pertl, Felix, Juan Carlos A Sobarzo Ponce, Lubuna B Shafeek, Tobias Cramer,
    and Scott R Waitukaitis. “Quantifying Nanoscale Charge Density Features of Contact-Charged
    Surfaces with an FEM/KPFM-Hybrid Approach.” <i>Physical Review Materials</i>.
    American Physical Society, 2022. <a href="https://doi.org/10.1103/PhysRevMaterials.6.125605">https://doi.org/10.1103/PhysRevMaterials.6.125605</a>.
  ieee: F. Pertl, J. C. A. Sobarzo Ponce, L. B. Shafeek, T. Cramer, and S. R. Waitukaitis,
    “Quantifying nanoscale charge density features of contact-charged surfaces with
    an FEM/KPFM-hybrid approach,” <i>Physical Review Materials</i>, vol. 6, no. 12.
    American Physical Society, 2022.
  ista: Pertl F, Sobarzo Ponce JCA, Shafeek LB, Cramer T, Waitukaitis SR. 2022. Quantifying
    nanoscale charge density features of contact-charged surfaces with an FEM/KPFM-hybrid
    approach. Physical Review Materials. 6(12), 125605.
  mla: Pertl, Felix, et al. “Quantifying Nanoscale Charge Density Features of Contact-Charged
    Surfaces with an FEM/KPFM-Hybrid Approach.” <i>Physical Review Materials</i>,
    vol. 6, no. 12, 125605, American Physical Society, 2022, doi:<a href="https://doi.org/10.1103/PhysRevMaterials.6.125605">10.1103/PhysRevMaterials.6.125605</a>.
  short: F. Pertl, J.C.A. Sobarzo Ponce, L.B. Shafeek, T. Cramer, S.R. Waitukaitis,
    Physical Review Materials 6 (2022).
date_created: 2023-01-08T23:00:53Z
date_published: 2022-12-29T00:00:00Z
date_updated: 2023-08-03T14:11:29Z
day: '29'
department:
- _id: ScWa
- _id: NanoFab
doi: 10.1103/PhysRevMaterials.6.125605
ec_funded: 1
external_id:
  arxiv:
  - '2209.01889'
  isi:
  - '000908384800001'
intvolume: '         6'
isi: 1
issue: '12'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: ' https://doi.org/10.48550/arXiv.2209.01889'
month: '12'
oa: 1
oa_version: Preprint
project:
- _id: 0aa60e99-070f-11eb-9043-a6de6bdc3afa
  call_identifier: H2020
  grant_number: '949120'
  name: 'Tribocharge: a multi-scale approach to an enduring problem in physics'
publication: Physical Review Materials
publication_identifier:
  eissn:
  - 2475-9953
publication_status: published
publisher: American Physical Society
quality_controlled: '1'
scopus_import: '1'
status: public
title: Quantifying nanoscale charge density features of contact-charged surfaces with
  an FEM/KPFM-hybrid approach
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 6
year: '2022'
...
---
_id: '12110'
abstract:
- lang: eng
  text: A recently proposed approach for avoiding the ultraviolet divergence of Hamiltonians
    with particle creation is based on interior-boundary conditions (IBCs). The approach
    works well in the non-relativistic case, i.e., for the Laplacian operator. Here,
    we study how the approach can be applied to Dirac operators. While this has successfully
    been done already in one space dimension, and more generally for codimension-1
    boundaries, the situation of point sources in three dimensions corresponds to
    a codimension-3 boundary. One would expect that, for such a boundary, Dirac operators
    do not allow for boundary conditions because they are known not to allow for point
    interactions in 3D, which also correspond to a boundary condition. Indeed, we
    confirm this expectation here by proving that there is no self-adjoint operator
    on a (truncated) Fock space that would correspond to a Dirac operator with an
    IBC at configurations with a particle at the origin. However, we also present
    a positive result showing that there are self-adjoint operators with an IBC (on
    the boundary consisting of configurations with a particle at the origin) that
    are away from those configurations, given by a Dirac operator plus a sufficiently
    strong Coulomb potential.
acknowledgement: "J.H. gratefully acknowledges the partial financial support by the
  ERC Advanced Grant “RMTBeyond” under Grant No. 101020331.\r\n"
article_number: '122302'
article_processing_charge: No
article_type: original
author:
- first_name: Sven Joscha
  full_name: Henheik, Sven Joscha
  id: 31d731d7-d235-11ea-ad11-b50331c8d7fb
  last_name: Henheik
  orcid: 0000-0003-1106-327X
- first_name: Roderich
  full_name: Tumulka, Roderich
  last_name: Tumulka
citation:
  ama: Henheik SJ, Tumulka R. Interior-boundary conditions for the Dirac equation
    at point sources in three dimensions. <i>Journal of Mathematical Physics</i>.
    2022;63(12). doi:<a href="https://doi.org/10.1063/5.0104675">10.1063/5.0104675</a>
  apa: Henheik, S. J., &#38; Tumulka, R. (2022). Interior-boundary conditions for
    the Dirac equation at point sources in three dimensions. <i>Journal of Mathematical
    Physics</i>. AIP Publishing. <a href="https://doi.org/10.1063/5.0104675">https://doi.org/10.1063/5.0104675</a>
  chicago: Henheik, Sven Joscha, and Roderich Tumulka. “Interior-Boundary Conditions
    for the Dirac Equation at Point Sources in Three Dimensions.” <i>Journal of Mathematical
    Physics</i>. AIP Publishing, 2022. <a href="https://doi.org/10.1063/5.0104675">https://doi.org/10.1063/5.0104675</a>.
  ieee: S. J. Henheik and R. Tumulka, “Interior-boundary conditions for the Dirac
    equation at point sources in three dimensions,” <i>Journal of Mathematical Physics</i>,
    vol. 63, no. 12. AIP Publishing, 2022.
  ista: Henheik SJ, Tumulka R. 2022. Interior-boundary conditions for the Dirac equation
    at point sources in three dimensions. Journal of Mathematical Physics. 63(12),
    122302.
  mla: Henheik, Sven Joscha, and Roderich Tumulka. “Interior-Boundary Conditions for
    the Dirac Equation at Point Sources in Three Dimensions.” <i>Journal of Mathematical
    Physics</i>, vol. 63, no. 12, 122302, AIP Publishing, 2022, doi:<a href="https://doi.org/10.1063/5.0104675">10.1063/5.0104675</a>.
  short: S.J. Henheik, R. Tumulka, Journal of Mathematical Physics 63 (2022).
date_created: 2023-01-08T23:00:53Z
date_published: 2022-12-01T00:00:00Z
date_updated: 2023-08-03T14:12:01Z
day: '01'
ddc:
- '510'
department:
- _id: LaEr
doi: 10.1063/5.0104675
ec_funded: 1
external_id:
  isi:
  - '000900748900002'
file:
- access_level: open_access
  checksum: 5150287295e0ce4f12462c990744d65d
  content_type: application/pdf
  creator: dernst
  date_created: 2023-01-20T11:58:59Z
  date_updated: 2023-01-20T11:58:59Z
  file_id: '12327'
  file_name: 2022_JourMathPhysics_Henheik.pdf
  file_size: 5436804
  relation: main_file
  success: 1
file_date_updated: 2023-01-20T11:58:59Z
has_accepted_license: '1'
intvolume: '        63'
isi: 1
issue: '12'
language:
- iso: eng
month: '12'
oa: 1
oa_version: Published Version
project:
- _id: 62796744-2b32-11ec-9570-940b20777f1d
  call_identifier: H2020
  grant_number: '101020331'
  name: Random matrices beyond Wigner-Dyson-Mehta
publication: Journal of Mathematical Physics
publication_identifier:
  issn:
  - 0022-2488
publication_status: published
publisher: AIP Publishing
quality_controlled: '1'
scopus_import: '1'
status: public
title: Interior-boundary conditions for the Dirac equation at point sources in three
  dimensions
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 63
year: '2022'
...
---
_id: '12111'
abstract:
- lang: eng
  text: Quantum impurities exhibit fascinating many-body phenomena when the small
    interacting impurity changes the physics of a large noninteracting environment.
    The characterisation of such strongly correlated nonperturbative effects is particularly
    challenging due to the infinite size of the environment, and the inability of
    local correlators to capture the buildup of long-ranged entanglement in the system.
    Here, we harness an entanglement-based observable—the purity of the impurity—as
    a witness for the formation of strong correlations. We showcase the utility of
    our scheme by exactly solving the open Kondo box model in the small box limit,
    and thus describe all-electronic dot-cavity devices. Specifically, we conclusively
    characterize the metal-to-insulator phase transition in the system and identify
    how the (conducting) dot-lead Kondo singlet is quenched by an (insulating) intraimpurity
    singlet formation. Furthermore, we propose an experimentally feasible tomography
    protocol for the measurement of the purity, which motivates the observation of
    impurity physics through their entanglement build up.
acknowledgement: We thank G. Blatter, T. Ihn, K. Ensslin, M. Goldstein, C. Carisch,
  and J. del Pino for illuminating discussions and acknowledge financial support from
  the Swiss National Science Foundation (SNSF) through Project No. 190078, and from
  the Deutsche Forschungsgemeinschaft (DFG) - Project No. 449653034. Our numerical
  implementations are based on the ITensors JULIA library [64].
article_number: '043177'
article_processing_charge: No
article_type: original
author:
- first_name: Lidia
  full_name: Stocker, Lidia
  last_name: Stocker
- first_name: Stefan
  full_name: Sack, Stefan
  id: dd622248-f6e0-11ea-865d-ce382a1c81a5
  last_name: Sack
- first_name: Michael S.
  full_name: Ferguson, Michael S.
  last_name: Ferguson
- first_name: Oded
  full_name: Zilberberg, Oded
  last_name: Zilberberg
citation:
  ama: Stocker L, Sack S, Ferguson MS, Zilberberg O. Entanglement-based observables
    for quantum impurities. <i>Physical Review Research</i>. 2022;4(4). doi:<a href="https://doi.org/10.1103/PhysRevResearch.4.043177">10.1103/PhysRevResearch.4.043177</a>
  apa: Stocker, L., Sack, S., Ferguson, M. S., &#38; Zilberberg, O. (2022). Entanglement-based
    observables for quantum impurities. <i>Physical Review Research</i>. American
    Physical Society. <a href="https://doi.org/10.1103/PhysRevResearch.4.043177">https://doi.org/10.1103/PhysRevResearch.4.043177</a>
  chicago: Stocker, Lidia, Stefan Sack, Michael S. Ferguson, and Oded Zilberberg.
    “Entanglement-Based Observables for Quantum Impurities.” <i>Physical Review Research</i>.
    American Physical Society, 2022. <a href="https://doi.org/10.1103/PhysRevResearch.4.043177">https://doi.org/10.1103/PhysRevResearch.4.043177</a>.
  ieee: L. Stocker, S. Sack, M. S. Ferguson, and O. Zilberberg, “Entanglement-based
    observables for quantum impurities,” <i>Physical Review Research</i>, vol. 4,
    no. 4. American Physical Society, 2022.
  ista: Stocker L, Sack S, Ferguson MS, Zilberberg O. 2022. Entanglement-based observables
    for quantum impurities. Physical Review Research. 4(4), 043177.
  mla: Stocker, Lidia, et al. “Entanglement-Based Observables for Quantum Impurities.”
    <i>Physical Review Research</i>, vol. 4, no. 4, 043177, American Physical Society,
    2022, doi:<a href="https://doi.org/10.1103/PhysRevResearch.4.043177">10.1103/PhysRevResearch.4.043177</a>.
  short: L. Stocker, S. Sack, M.S. Ferguson, O. Zilberberg, Physical Review Research
    4 (2022).
date_created: 2023-01-08T23:00:53Z
date_published: 2022-12-01T00:00:00Z
date_updated: 2023-02-13T09:08:28Z
day: '01'
ddc:
- '530'
department:
- _id: MaSe
doi: 10.1103/PhysRevResearch.4.043177
file:
- access_level: open_access
  checksum: 556820cf6e4af77c8476e5b8f4114d1a
  content_type: application/pdf
  creator: dernst
  date_created: 2023-01-20T12:03:31Z
  date_updated: 2023-01-20T12:03:31Z
  file_id: '12328'
  file_name: 2022_PhysicalReviewResearch_Stocker.pdf
  file_size: 2941167
  relation: main_file
  success: 1
file_date_updated: 2023-01-20T12:03:31Z
has_accepted_license: '1'
intvolume: '         4'
issue: '4'
language:
- iso: eng
month: '12'
oa: 1
oa_version: Published Version
publication: Physical Review Research
publication_identifier:
  issn:
  - 2643-1564
publication_status: published
publisher: American Physical Society
quality_controlled: '1'
scopus_import: '1'
status: public
title: Entanglement-based observables for quantum impurities
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 4
year: '2022'
...
---
_id: '12116'
abstract:
- lang: eng
  text: Russia’s unprovoked attack on Ukraine has destroyed civilian infrastructure,
    including universities, research centers, and other academic infrastructure (1).
    Many Ukrainian scholars and researchers remain in Ukraine, and their work has
    suffered from major setbacks (2–4). We call on international scientists and institutions
    to support them.
article_processing_charge: No
article_type: letter_note
author:
- first_name: Karishma
  full_name: Chhugani, Karishma
  last_name: Chhugani
- first_name: Alina
  full_name: Frolova, Alina
  last_name: Frolova
- first_name: Yuriy
  full_name: Salyha, Yuriy
  last_name: Salyha
- first_name: Andrada
  full_name: Fiscutean, Andrada
  last_name: Fiscutean
- first_name: Oksana
  full_name: Zlenko, Oksana
  last_name: Zlenko
- first_name: Sanita
  full_name: Reinsone, Sanita
  last_name: Reinsone
- first_name: Walter W.
  full_name: Wolfsberger, Walter W.
  last_name: Wolfsberger
- first_name: Oleksandra V.
  full_name: Ivashchenko, Oleksandra V.
  last_name: Ivashchenko
- first_name: Megi
  full_name: Maci, Megi
  last_name: Maci
- first_name: Dmytro
  full_name: Dziuba, Dmytro
  last_name: Dziuba
- first_name: Andrii
  full_name: Parkhomenko, Andrii
  last_name: Parkhomenko
- first_name: Eric
  full_name: Bortz, Eric
  last_name: Bortz
- first_name: Fyodor
  full_name: Kondrashov, Fyodor
  id: 44FDEF62-F248-11E8-B48F-1D18A9856A87
  last_name: Kondrashov
  orcid: 0000-0001-8243-4694
- first_name: Paweł P.
  full_name: Łabaj, Paweł P.
  last_name: Łabaj
- first_name: Veronika
  full_name: Romero, Veronika
  last_name: Romero
- first_name: Jakub
  full_name: Hlávka, Jakub
  last_name: Hlávka
- first_name: Taras K.
  full_name: Oleksyk, Taras K.
  last_name: Oleksyk
- first_name: Serghei
  full_name: Mangul, Serghei
  last_name: Mangul
citation:
  ama: Chhugani K, Frolova A, Salyha Y, et al. Remote opportunities for scholars in
    Ukraine. <i>Science</i>. 2022;378(6626):1285-1286. doi:<a href="https://doi.org/10.1126/science.adg0797">10.1126/science.adg0797</a>
  apa: Chhugani, K., Frolova, A., Salyha, Y., Fiscutean, A., Zlenko, O., Reinsone,
    S., … Mangul, S. (2022). Remote opportunities for scholars in Ukraine. <i>Science</i>.
    American Association for the Advancement of Science. <a href="https://doi.org/10.1126/science.adg0797">https://doi.org/10.1126/science.adg0797</a>
  chicago: Chhugani, Karishma, Alina Frolova, Yuriy Salyha, Andrada Fiscutean, Oksana
    Zlenko, Sanita Reinsone, Walter W. Wolfsberger, et al. “Remote Opportunities for
    Scholars in Ukraine.” <i>Science</i>. American Association for the Advancement
    of Science, 2022. <a href="https://doi.org/10.1126/science.adg0797">https://doi.org/10.1126/science.adg0797</a>.
  ieee: K. Chhugani <i>et al.</i>, “Remote opportunities for scholars in Ukraine,”
    <i>Science</i>, vol. 378, no. 6626. American Association for the Advancement of
    Science, pp. 1285–1286, 2022.
  ista: Chhugani K, Frolova A, Salyha Y, Fiscutean A, Zlenko O, Reinsone S, Wolfsberger
    WW, Ivashchenko OV, Maci M, Dziuba D, Parkhomenko A, Bortz E, Kondrashov F, Łabaj
    PP, Romero V, Hlávka J, Oleksyk TK, Mangul S. 2022. Remote opportunities for scholars
    in Ukraine. Science. 378(6626), 1285–1286.
  mla: Chhugani, Karishma, et al. “Remote Opportunities for Scholars in Ukraine.”
    <i>Science</i>, vol. 378, no. 6626, American Association for the Advancement of
    Science, 2022, pp. 1285–86, doi:<a href="https://doi.org/10.1126/science.adg0797">10.1126/science.adg0797</a>.
  short: K. Chhugani, A. Frolova, Y. Salyha, A. Fiscutean, O. Zlenko, S. Reinsone,
    W.W. Wolfsberger, O.V. Ivashchenko, M. Maci, D. Dziuba, A. Parkhomenko, E. Bortz,
    F. Kondrashov, P.P. Łabaj, V. Romero, J. Hlávka, T.K. Oleksyk, S. Mangul, Science
    378 (2022) 1285–1286.
date_created: 2023-01-12T11:56:30Z
date_published: 2022-12-22T00:00:00Z
date_updated: 2023-10-03T11:01:06Z
day: '22'
department:
- _id: FyKo
doi: 10.1126/science.adg0797
external_id:
  isi:
  - '000963463700023'
intvolume: '       378'
isi: 1
issue: '6626'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://doi.org/10.1126/science.adg0797
month: '12'
oa: 1
oa_version: Published Version
page: 1285-1286
publication: Science
publication_identifier:
  eissn:
  - 1095-9203
  issn:
  - 0036-8075
publication_status: published
publisher: American Association for the Advancement of Science
quality_controlled: '1'
scopus_import: '1'
status: public
title: Remote opportunities for scholars in Ukraine
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 378
year: '2022'
...
---
_id: '12117'
abstract:
- lang: eng
  text: "To understand how potential gene manipulations affect in vitro microglia,
    we provide a set of short protocols to evaluate microglia identity and function.
    We detail steps for immunostaining to determine microglia identity. We describe
    three functional assays for microglia: phagocytosis, calcium response following
    ATP stimulation, and cytokine expression upon inflammatory stimuli. We apply these
    protocols to human induced-pluripotent-stem-cell (hiPSC)-derived microglia, but
    they can be also applied to other in vitro microglial models including primary
    mouse microglia.\r\nFor complete details on the use and execution of this protocol,
    please refer to Bartalska et al. (2022).1"
acknowledged_ssus:
- _id: Bio
acknowledgement: This project has received funding from the European Research Council
  (ERC) under the European Union’s Horizon 2020 research and innovation program (grant
  No. 715571 to S.S.) and from the Gesellschaft für Forschungsförderung Niederösterreich
  (grant No. Sc19-017 to V.H.). We thank Rouven Schulz and Alessandro Venturino for
  their insights into functional assays and data analysis, Verena Seiboth for insights
  into necessary institutional permission, and ISTA imaging & optics facility (IOF)
  especially Bernhard Hochreiter for their support.
article_number: '101866'
article_processing_charge: No
article_type: letter_note
author:
- first_name: Verena
  full_name: Hübschmann, Verena
  id: 32B7C918-F248-11E8-B48F-1D18A9856A87
  last_name: Hübschmann
- first_name: Medina
  full_name: Korkut, Medina
  id: 4B51CE74-F248-11E8-B48F-1D18A9856A87
  last_name: Korkut
  orcid: 0000-0003-4309-2251
- first_name: Sandra
  full_name: Siegert, Sandra
  id: 36ACD32E-F248-11E8-B48F-1D18A9856A87
  last_name: Siegert
  orcid: 0000-0001-8635-0877
citation:
  ama: Hübschmann V, Korkut M, Siegert S. Assessing human iPSC-derived microglia identity
    and function by immunostaining, phagocytosis, calcium activity, and inflammation
    assay. <i>STAR Protocols</i>. 2022;3(4). doi:<a href="https://doi.org/10.1016/j.xpro.2022.101866">10.1016/j.xpro.2022.101866</a>
  apa: Hübschmann, V., Korkut, M., &#38; Siegert, S. (2022). Assessing human iPSC-derived
    microglia identity and function by immunostaining, phagocytosis, calcium activity,
    and inflammation assay. <i>STAR Protocols</i>. Elsevier. <a href="https://doi.org/10.1016/j.xpro.2022.101866">https://doi.org/10.1016/j.xpro.2022.101866</a>
  chicago: Hübschmann, Verena, Medina Korkut, and Sandra Siegert. “Assessing Human
    IPSC-Derived Microglia Identity and Function by Immunostaining, Phagocytosis,
    Calcium Activity, and Inflammation Assay.” <i>STAR Protocols</i>. Elsevier, 2022.
    <a href="https://doi.org/10.1016/j.xpro.2022.101866">https://doi.org/10.1016/j.xpro.2022.101866</a>.
  ieee: V. Hübschmann, M. Korkut, and S. Siegert, “Assessing human iPSC-derived microglia
    identity and function by immunostaining, phagocytosis, calcium activity, and inflammation
    assay,” <i>STAR Protocols</i>, vol. 3, no. 4. Elsevier, 2022.
  ista: Hübschmann V, Korkut M, Siegert S. 2022. Assessing human iPSC-derived microglia
    identity and function by immunostaining, phagocytosis, calcium activity, and inflammation
    assay. STAR Protocols. 3(4), 101866.
  mla: Hübschmann, Verena, et al. “Assessing Human IPSC-Derived Microglia Identity
    and Function by Immunostaining, Phagocytosis, Calcium Activity, and Inflammation
    Assay.” <i>STAR Protocols</i>, vol. 3, no. 4, 101866, Elsevier, 2022, doi:<a href="https://doi.org/10.1016/j.xpro.2022.101866">10.1016/j.xpro.2022.101866</a>.
  short: V. Hübschmann, M. Korkut, S. Siegert, STAR Protocols 3 (2022).
date_created: 2023-01-12T11:56:38Z
date_published: 2022-12-16T00:00:00Z
date_updated: 2023-11-02T12:21:32Z
day: '16'
ddc:
- '570'
department:
- _id: SaSi
- _id: GradSch
doi: 10.1016/j.xpro.2022.101866
ec_funded: 1
file:
- access_level: open_access
  checksum: 3c71b8a60633d42c2f77c49025d5559b
  content_type: application/pdf
  creator: dernst
  date_created: 2023-01-23T09:50:51Z
  date_updated: 2023-01-23T09:50:51Z
  file_id: '12340'
  file_name: 2022_STARProtocols_Huebschmann.pdf
  file_size: 6251945
  relation: main_file
  success: 1
file_date_updated: 2023-01-23T09:50:51Z
has_accepted_license: '1'
intvolume: '         3'
issue: '4'
keyword:
- General Immunology and Microbiology
- General Biochemistry
- Genetics and Molecular Biology
- General Neuroscience
language:
- iso: eng
month: '12'
oa: 1
oa_version: Published Version
project:
- _id: 25D4A630-B435-11E9-9278-68D0E5697425
  call_identifier: H2020
  grant_number: '715571'
  name: Microglia action towards neuronal circuit formation and function in health
    and disease
- _id: 9B99D380-BA93-11EA-9121-9846C619BF3A
  grant_number: SC19-017
  name: How human microglia shape developing neurons during health and inflammation
publication: STAR Protocols
publication_identifier:
  issn:
  - 2666-1667
publication_status: published
publisher: Elsevier
quality_controlled: '1'
related_material:
  record:
  - id: '11478'
    relation: other
    status: public
scopus_import: '1'
status: public
title: Assessing human iPSC-derived microglia identity and function by immunostaining,
  phagocytosis, calcium activity, and inflammation assay
tmp:
  image: /images/cc_by_nc_nd.png
  legal_code_url: https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode
  name: Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
    (CC BY-NC-ND 4.0)
  short: CC BY-NC-ND (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 3
year: '2022'
...
---
_id: '12118'
abstract:
- lang: eng
  text: Hybrid semiconductor–superconductor devices hold great promise for realizing
    topological quantum computing with Majorana zero modes1,2,3,4,5. However, multiple
    claims of Majorana detection, based on either tunnelling6,7,8,9,10 or Coulomb
    blockade (CB) spectroscopy11,12, remain disputed. Here we devise an experimental
    protocol that allows us to perform both types of measurement on the same hybrid
    island by adjusting its charging energy via tunable junctions to the normal leads.
    This method reduces ambiguities of Majorana detections by checking the consistency
    between CB spectroscopy and zero-bias peaks in non-blockaded transport. Specifically,
    we observe junction-dependent, even–odd modulated, single-electron CB peaks in
    InAs/Al hybrid nanowires without concomitant low-bias peaks in tunnelling spectroscopy.
    We provide a theoretical interpretation of the experimental observations in terms
    of low-energy, longitudinally confined island states rather than overlapping Majorana
    modes. Our results highlight the importance of combined measurements on the same
    device for the identification of topological Majorana zero modes.
acknowledged_ssus:
- _id: M-Shop
- _id: NanoFab
acknowledgement: We thank P. Krogstrup for providing us with the NW materials. We
  thank A. Higginbotham, E. J. H. Lee, C. Marcus and S. Vaitiekėnas for helpful discussions
  and G. Steffensen for his input on the diffusive Little-Parks theory. This research
  was supported by the Scientific Service Units of ISTA through resources provided
  by the MIBA Machine Shop and the nanofabrication facility; the NOMIS Foundation;
  the CSIC Interdisciplinary Thematic Platform (PTI+) on Quantum Technologies (PTI-QTEP+).
  A.H. acknowledges support from H2020-MSCA-IF-2018/844511. ICN2 also acknowledges
  funding from Generalitat de Catalunya 2017 SGR 327. ICN2 is supported by the Severo
  Ochoa Program from Spanish MINECO (Grant no. SEV-2017-0706) and is funded by the
  CERCA Programme/Generalitat de Catalunya. Part of the present work has been performed
  in the framework of Universitat Autònoma de Barcelona Materials Science PhD programme.
  Authors acknowledge the use of instrumentation as well as the technical advice provided
  by the National Facility ELECMI ICTS, node ‘Laboratorio de Microscopías Avanzadas’
  at University of Zaragoza. This project has received funding from the European Union’s
  Horizon 2020 research and innovation programme under grant agreement no. 823717-ESTEEM3.
  This study was supported by MCIN with funding from European Union NextGenerationEU
  (PRTR-C17.I1) and Generalitat de Catalunya. This research is part of the CSIC programme
  for the Spanish Recovery, Transformation and Resilience Plan funded by the Recovery
  and Resilience Facility of the European Union, established by the Regulation (EU)
  2020/2094. We thank support from Grant PGC2018-097018-BI00, project FlagERA TOPOGRAPH
  (PCI2018-093026) and project NANOGEN (PID2020-116093RB-C43), funded by MCIN/AEI/10.13039/501100011033/
  and by ‘ERDF A way of making Europe’, by the European Union. M. Botifoll acknowledges
  support from SUR Generalitat de Catalunya and the EU Social Fund (project ref. 2020
  FI 00103).
article_processing_charge: No
article_type: original
arxiv: 1
author:
- first_name: Marco
  full_name: Valentini, Marco
  id: C0BB2FAC-D767-11E9-B658-BC13E6697425
  last_name: Valentini
- first_name: Maksim
  full_name: Borovkov, Maksim
  id: 2ac7a0a2-3562-11eb-9256-fbd18ea55087
  last_name: Borovkov
- first_name: Elsa
  full_name: Prada, Elsa
  last_name: Prada
- first_name: Sara
  full_name: Martí-Sánchez, Sara
  last_name: Martí-Sánchez
- first_name: Marc
  full_name: Botifoll, Marc
  last_name: Botifoll
- first_name: Andrea C
  full_name: Hofmann, Andrea C
  id: 340F461A-F248-11E8-B48F-1D18A9856A87
  last_name: Hofmann
- first_name: Jordi
  full_name: Arbiol, Jordi
  last_name: Arbiol
- first_name: Ramón
  full_name: Aguado, Ramón
  last_name: Aguado
- first_name: Pablo
  full_name: San-Jose, Pablo
  last_name: San-Jose
- first_name: Georgios
  full_name: Katsaros, Georgios
  id: 38DB5788-F248-11E8-B48F-1D18A9856A87
  last_name: Katsaros
  orcid: 0000-0001-8342-202X
citation:
  ama: Valentini M, Borovkov M, Prada E, et al. Majorana-like Coulomb spectroscopy
    in the absence of zero-bias peaks. <i>Nature</i>. 2022;612(7940):442-447. doi:<a
    href="https://doi.org/10.1038/s41586-022-05382-w">10.1038/s41586-022-05382-w</a>
  apa: Valentini, M., Borovkov, M., Prada, E., Martí-Sánchez, S., Botifoll, M., Hofmann,
    A. C., … Katsaros, G. (2022). Majorana-like Coulomb spectroscopy in the absence
    of zero-bias peaks. <i>Nature</i>. Springer Nature. <a href="https://doi.org/10.1038/s41586-022-05382-w">https://doi.org/10.1038/s41586-022-05382-w</a>
  chicago: Valentini, Marco, Maksim Borovkov, Elsa Prada, Sara Martí-Sánchez, Marc
    Botifoll, Andrea C Hofmann, Jordi Arbiol, Ramón Aguado, Pablo San-Jose, and Georgios
    Katsaros. “Majorana-like Coulomb Spectroscopy in the Absence of Zero-Bias Peaks.”
    <i>Nature</i>. Springer Nature, 2022. <a href="https://doi.org/10.1038/s41586-022-05382-w">https://doi.org/10.1038/s41586-022-05382-w</a>.
  ieee: M. Valentini <i>et al.</i>, “Majorana-like Coulomb spectroscopy in the absence
    of zero-bias peaks,” <i>Nature</i>, vol. 612, no. 7940. Springer Nature, pp. 442–447,
    2022.
  ista: Valentini M, Borovkov M, Prada E, Martí-Sánchez S, Botifoll M, Hofmann AC,
    Arbiol J, Aguado R, San-Jose P, Katsaros G. 2022. Majorana-like Coulomb spectroscopy
    in the absence of zero-bias peaks. Nature. 612(7940), 442–447.
  mla: Valentini, Marco, et al. “Majorana-like Coulomb Spectroscopy in the Absence
    of Zero-Bias Peaks.” <i>Nature</i>, vol. 612, no. 7940, Springer Nature, 2022,
    pp. 442–47, doi:<a href="https://doi.org/10.1038/s41586-022-05382-w">10.1038/s41586-022-05382-w</a>.
  short: M. Valentini, M. Borovkov, E. Prada, S. Martí-Sánchez, M. Botifoll, A.C.
    Hofmann, J. Arbiol, R. Aguado, P. San-Jose, G. Katsaros, Nature 612 (2022) 442–447.
date_created: 2023-01-12T11:56:45Z
date_published: 2022-12-15T00:00:00Z
date_updated: 2024-02-21T12:35:33Z
day: '15'
department:
- _id: GeKa
doi: 10.1038/s41586-022-05382-w
ec_funded: 1
external_id:
  arxiv:
  - '2203.07829'
  isi:
  - '000899725400001'
intvolume: '       612'
isi: 1
issue: '7940'
keyword:
- Multidisciplinary
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: ' https://doi.org/10.48550/arXiv.2203.07829'
month: '12'
oa: 1
oa_version: Preprint
page: 442-447
project:
- _id: 26A151DA-B435-11E9-9278-68D0E5697425
  call_identifier: H2020
  grant_number: '844511'
  name: Majorana bound states in Ge/SiGe heterostructures
publication: Nature
publication_identifier:
  eissn:
  - 1476-4687
  issn:
  - 0028-0836
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
related_material:
  link:
  - description: News on ISTA Website
    relation: press_release
    url: https://ista.ac.at/en/news/imposter-particles-revealed-and-explained/
  record:
  - id: '13286'
    relation: dissertation_contains
    status: public
  - id: '12522'
    relation: research_data
    status: public
scopus_import: '1'
status: public
title: Majorana-like Coulomb spectroscopy in the absence of zero-bias peaks
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 612
year: '2022'
...
---
_id: '12119'
abstract:
- lang: eng
  text: Intravascular neutrophils and platelets collaborate in maintaining host integrity,
    but their interaction can also trigger thrombotic complications. We report here
    that cooperation between neutrophil and platelet lineages extends to the earliest
    stages of platelet formation by megakaryocytes in the bone marrow. Using intravital
    microscopy, we show that neutrophils “plucked” intravascular megakaryocyte extensions,
    termed proplatelets, to control platelet production. Following CXCR4-CXCL12-dependent
    migration towards perisinusoidal megakaryocytes, plucking neutrophils actively
    pulled on proplatelets and triggered myosin light chain and extracellular-signal-regulated
    kinase activation through reactive oxygen species. By these mechanisms, neutrophils
    accelerate proplatelet growth and facilitate continuous release of platelets in
    steady state. Following myocardial infarction, plucking neutrophils drove excessive
    release of young, reticulated platelets and boosted the risk of recurrent ischemia.
    Ablation of neutrophil plucking normalized thrombopoiesis and reduced recurrent
    thrombosis after myocardial infarction and thrombus burden in venous thrombosis.
    We establish neutrophil plucking as a target to reduce thromboischemic events.
acknowledgement: "We thank Coung Kieu and Dominik van den Heuvel for excellent technical
  assistance. This work was supported by the German Research Foundation (PE2704/2-1,
  PE2704/3-1 to T.P., SFB 1123-project B06 to S.M., SFB1525 project A07 to D.S, TRR
  332 project A7 to C.S., PO 2247/2-1 to A.P., SFB1116-project B11 to A.P. and B12
  to M.K.), LMU Munich’s Institutional\r\nStrategy LMUexcellent within the framework
  of the German Excellence Initiative (No. 806 32 006 to T.P.), and by the German
  Centre for Cardiovascular Research (DZHK) to T.P. (Postdoc Start-up grant No. 100378833).
  This project has received funding from the European Research Council (ERC) under
  the European Union’s Horizon 2020 research and innovation program (grant agreement
  No. 833440 to S.M.). F.G. received funding from the European Union’s\r\nHorizon
  2020 research and innovation program under the Marie Sk1odowska-Curie grant agreement
  no. 747687. A.H. was funded by RTI2018-095497-B-I00 from Ministerio de Ciencia e
  Innovacio´ n (MICINN), HR17_00527 from Fundacion La Caixa, and Transatlantic Network
  of Excellence (TNE-18CVD04) from the Leducq Foundation. The CNIC is supported by
  the MICINN and the Pro CNIC Foundation and is a Severo Ochoa Center of Excellence
  (CEX2020-001041-S). A.P. was supported by the Forschungskommission of the Medical
  Faculty of the Heinrich-Heine-Universität Düsseldorf (No. 18-2019 to A.P.). C.G.
  was supported by the Helmholtz Alliance ‘Aging and Metabolic Programming, AMPro,’
  by the German Federal\r\nMinistry of Education and Research to the German Center
  for Diabetes Research (DZD), and by the Bavarian State Ministry of Health and Care
  through the research project DigiMed Bayern."
article_processing_charge: No
article_type: original
author:
- first_name: Tobias
  full_name: Petzold, Tobias
  last_name: Petzold
- first_name: Zhe
  full_name: Zhang, Zhe
  last_name: Zhang
- first_name: Iván
  full_name: Ballesteros, Iván
  last_name: Ballesteros
- first_name: Inas
  full_name: Saleh, Inas
  last_name: Saleh
- first_name: Amin
  full_name: Polzin, Amin
  last_name: Polzin
- first_name: Manuela
  full_name: Thienel, Manuela
  last_name: Thienel
- first_name: Lulu
  full_name: Liu, Lulu
  last_name: Liu
- first_name: Qurrat
  full_name: Ul Ain, Qurrat
  last_name: Ul Ain
- first_name: Vincent
  full_name: Ehreiser, Vincent
  last_name: Ehreiser
- first_name: Christian
  full_name: Weber, Christian
  last_name: Weber
- first_name: Badr
  full_name: Kilani, Badr
  last_name: Kilani
- first_name: Pontus
  full_name: Mertsch, Pontus
  last_name: Mertsch
- first_name: Jeremias
  full_name: Götschke, Jeremias
  last_name: Götschke
- first_name: Sophie
  full_name: Cremer, Sophie
  last_name: Cremer
- first_name: Wenwen
  full_name: Fu, Wenwen
  last_name: Fu
- first_name: Michael
  full_name: Lorenz, Michael
  last_name: Lorenz
- first_name: Hellen
  full_name: Ishikawa-Ankerhold, Hellen
  last_name: Ishikawa-Ankerhold
- first_name: Elisabeth
  full_name: Raatz, Elisabeth
  last_name: Raatz
- first_name: Shaza
  full_name: El-Nemr, Shaza
  last_name: El-Nemr
- first_name: Agnes
  full_name: Görlach, Agnes
  last_name: Görlach
- first_name: Esther
  full_name: Marhuenda, Esther
  last_name: Marhuenda
- first_name: Konstantin
  full_name: Stark, Konstantin
  last_name: Stark
- first_name: Joachim
  full_name: Pircher, Joachim
  last_name: Pircher
- first_name: David
  full_name: Stegner, David
  last_name: Stegner
- first_name: Christian
  full_name: Gieger, Christian
  last_name: Gieger
- first_name: Marc
  full_name: Schmidt-Supprian, Marc
  last_name: Schmidt-Supprian
- first_name: Florian R
  full_name: Gärtner, Florian R
  id: 397A88EE-F248-11E8-B48F-1D18A9856A87
  last_name: Gärtner
  orcid: 0000-0001-6120-3723
- first_name: Isaac
  full_name: Almendros, Isaac
  last_name: Almendros
- first_name: Malte
  full_name: Kelm, Malte
  last_name: Kelm
- first_name: Christian
  full_name: Schulz, Christian
  last_name: Schulz
- first_name: Andrés
  full_name: Hidalgo, Andrés
  last_name: Hidalgo
- first_name: Steffen
  full_name: Massberg, Steffen
  last_name: Massberg
citation:
  ama: Petzold T, Zhang Z, Ballesteros I, et al. Neutrophil “plucking” on megakaryocytes
    drives platelet production and boosts cardiovascular disease. <i>Immunity</i>.
    2022;55(12):2285-2299.e7. doi:<a href="https://doi.org/10.1016/j.immuni.2022.10.001">10.1016/j.immuni.2022.10.001</a>
  apa: Petzold, T., Zhang, Z., Ballesteros, I., Saleh, I., Polzin, A., Thienel, M.,
    … Massberg, S. (2022). Neutrophil “plucking” on megakaryocytes drives platelet
    production and boosts cardiovascular disease. <i>Immunity</i>. Elsevier. <a href="https://doi.org/10.1016/j.immuni.2022.10.001">https://doi.org/10.1016/j.immuni.2022.10.001</a>
  chicago: Petzold, Tobias, Zhe Zhang, Iván Ballesteros, Inas Saleh, Amin Polzin,
    Manuela Thienel, Lulu Liu, et al. “Neutrophil ‘Plucking’ on Megakaryocytes Drives
    Platelet Production and Boosts Cardiovascular Disease.” <i>Immunity</i>. Elsevier,
    2022. <a href="https://doi.org/10.1016/j.immuni.2022.10.001">https://doi.org/10.1016/j.immuni.2022.10.001</a>.
  ieee: T. Petzold <i>et al.</i>, “Neutrophil ‘plucking’ on megakaryocytes drives
    platelet production and boosts cardiovascular disease,” <i>Immunity</i>, vol.
    55, no. 12. Elsevier, p. 2285–2299.e7, 2022.
  ista: Petzold T, Zhang Z, Ballesteros I, Saleh I, Polzin A, Thienel M, Liu L, Ul
    Ain Q, Ehreiser V, Weber C, Kilani B, Mertsch P, Götschke J, Cremer S, Fu W, Lorenz
    M, Ishikawa-Ankerhold H, Raatz E, El-Nemr S, Görlach A, Marhuenda E, Stark K,
    Pircher J, Stegner D, Gieger C, Schmidt-Supprian M, Gärtner FR, Almendros I, Kelm
    M, Schulz C, Hidalgo A, Massberg S. 2022. Neutrophil “plucking” on megakaryocytes
    drives platelet production and boosts cardiovascular disease. Immunity. 55(12),
    2285–2299.e7.
  mla: Petzold, Tobias, et al. “Neutrophil ‘Plucking’ on Megakaryocytes Drives Platelet
    Production and Boosts Cardiovascular Disease.” <i>Immunity</i>, vol. 55, no. 12,
    Elsevier, 2022, p. 2285–2299.e7, doi:<a href="https://doi.org/10.1016/j.immuni.2022.10.001">10.1016/j.immuni.2022.10.001</a>.
  short: T. Petzold, Z. Zhang, I. Ballesteros, I. Saleh, A. Polzin, M. Thienel, L.
    Liu, Q. Ul Ain, V. Ehreiser, C. Weber, B. Kilani, P. Mertsch, J. Götschke, S.
    Cremer, W. Fu, M. Lorenz, H. Ishikawa-Ankerhold, E. Raatz, S. El-Nemr, A. Görlach,
    E. Marhuenda, K. Stark, J. Pircher, D. Stegner, C. Gieger, M. Schmidt-Supprian,
    F.R. Gärtner, I. Almendros, M. Kelm, C. Schulz, A. Hidalgo, S. Massberg, Immunity
    55 (2022) 2285–2299.e7.
date_created: 2023-01-12T11:56:54Z
date_published: 2022-12-13T00:00:00Z
date_updated: 2023-08-03T14:21:51Z
day: '13'
ddc:
- '570'
department:
- _id: MiSi
doi: 10.1016/j.immuni.2022.10.001
ec_funded: 1
external_id:
  isi:
  - '000922019600003'
  pmid:
  - '36272416'
file:
- access_level: open_access
  checksum: 073267a9c0ad9f85a650053bc7b23777
  content_type: application/pdf
  creator: dernst
  date_created: 2023-01-23T10:18:48Z
  date_updated: 2023-01-23T10:18:48Z
  file_id: '12341'
  file_name: 2022_Immunity_Petzold.pdf
  file_size: 5299475
  relation: main_file
  success: 1
file_date_updated: 2023-01-23T10:18:48Z
has_accepted_license: '1'
intvolume: '        55'
isi: 1
issue: '12'
keyword:
- Infectious Diseases
- Immunology
- Immunology and Allergy
language:
- iso: eng
month: '12'
oa: 1
oa_version: Published Version
page: 2285-2299.e7
pmid: 1
project:
- _id: 260AA4E2-B435-11E9-9278-68D0E5697425
  call_identifier: H2020
  grant_number: '747687'
  name: Mechanical Adaptation of Lamellipodial Actin Networks in Migrating Cells
publication: Immunity
publication_identifier:
  issn:
  - 1074-7613
publication_status: published
publisher: Elsevier
quality_controlled: '1'
scopus_import: '1'
status: public
title: Neutrophil “plucking” on megakaryocytes drives platelet production and boosts
  cardiovascular disease
tmp:
  image: /images/cc_by_nc_nd.png
  legal_code_url: https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode
  name: Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
    (CC BY-NC-ND 4.0)
  short: CC BY-NC-ND (4.0)
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 55
year: '2022'
...
---
_id: '12120'
abstract:
- lang: eng
  text: Plant root architecture flexibly adapts to changing nitrate (NO3−) availability
    in the soil; however, the underlying molecular mechanism of this adaptive development
    remains under-studied. To explore the regulation of NO3−-mediated root growth,
    we screened for low-nitrate-resistant mutant (lonr) and identified mutants that
    were defective in the NAC transcription factor NAC075 (lonr1) as being less sensitive
    to low NO3− in terms of primary root growth. We show that NAC075 is a mobile transcription
    factor relocating from the root stele tissues to the endodermis based on NO3−
    availability. Under low-NO3− availability, the kinase CBL-interacting protein
    kinase 1 (CIPK1) is activated, and it phosphorylates NAC075, restricting its movement
    from the stele, which leads to the transcriptional regulation of downstream target
    WRKY53, consequently leading to adapted root architecture. Our work thus identifies
    an adaptive mechanism involving translocation of transcription factor based on
    nutrient availability and leading to cell-specific reprogramming of plant root
    growth.
acknowledgement: The authors are grateful to Jörg Kudla, Ying Miao, Yu Zheng, Gang
  Li, and Jun Zheng for providing published materials and to Wenkun Zhou and Caifu
  Jiang for helpful discussions. This work was supported by grants from the National
  Key Research and Development Program of China (2021YFF1000500), the National Natural
  Science Foundation of China (32170265 and 32022007), the Beijing Municipal Natural
  Science Foundation (5192011), and the Chinese Universities Scientific Fund (2022TC153).
article_processing_charge: No
article_type: original
author:
- first_name: Huixin
  full_name: Xiao, Huixin
  last_name: Xiao
- first_name: Yumei
  full_name: Hu, Yumei
  last_name: Hu
- first_name: Yaping
  full_name: Wang, Yaping
  last_name: Wang
- first_name: Jinkui
  full_name: Cheng, Jinkui
  last_name: Cheng
- first_name: Jinyi
  full_name: Wang, Jinyi
  last_name: Wang
- first_name: Guojingwei
  full_name: Chen, Guojingwei
  last_name: Chen
- first_name: Qian
  full_name: Li, Qian
  last_name: Li
- first_name: Shuwei
  full_name: Wang, Shuwei
  last_name: Wang
- first_name: Yalu
  full_name: Wang, Yalu
  last_name: Wang
- first_name: Shao-Shuai
  full_name: Wang, Shao-Shuai
  last_name: Wang
- first_name: Yi
  full_name: Wang, Yi
  last_name: Wang
- first_name: Wei
  full_name: Xuan, Wei
  last_name: Xuan
- first_name: Zhen
  full_name: Li, Zhen
  last_name: Li
- first_name: Yan
  full_name: Guo, Yan
  last_name: Guo
- first_name: Zhizhong
  full_name: Gong, Zhizhong
  last_name: Gong
- first_name: Jiří
  full_name: Friml, Jiří
  id: 4159519E-F248-11E8-B48F-1D18A9856A87
  last_name: Friml
  orcid: 0000-0002-8302-7596
- first_name: Jing
  full_name: Zhang, Jing
  last_name: Zhang
citation:
  ama: Xiao H, Hu Y, Wang Y, et al. Nitrate availability controls translocation of
    the transcription factor NAC075 for cell-type-specific reprogramming of root growth.
    <i>Developmental Cell</i>. 2022;57(23):2638-2651.e6. doi:<a href="https://doi.org/10.1016/j.devcel.2022.11.006">10.1016/j.devcel.2022.11.006</a>
  apa: Xiao, H., Hu, Y., Wang, Y., Cheng, J., Wang, J., Chen, G., … Zhang, J. (2022).
    Nitrate availability controls translocation of the transcription factor NAC075
    for cell-type-specific reprogramming of root growth. <i>Developmental Cell</i>.
    Elsevier. <a href="https://doi.org/10.1016/j.devcel.2022.11.006">https://doi.org/10.1016/j.devcel.2022.11.006</a>
  chicago: Xiao, Huixin, Yumei Hu, Yaping Wang, Jinkui Cheng, Jinyi Wang, Guojingwei
    Chen, Qian Li, et al. “Nitrate Availability Controls Translocation of the Transcription
    Factor NAC075 for Cell-Type-Specific Reprogramming of Root Growth.” <i>Developmental
    Cell</i>. Elsevier, 2022. <a href="https://doi.org/10.1016/j.devcel.2022.11.006">https://doi.org/10.1016/j.devcel.2022.11.006</a>.
  ieee: H. Xiao <i>et al.</i>, “Nitrate availability controls translocation of the
    transcription factor NAC075 for cell-type-specific reprogramming of root growth,”
    <i>Developmental Cell</i>, vol. 57, no. 23. Elsevier, p. 2638–2651.e6, 2022.
  ista: Xiao H, Hu Y, Wang Y, Cheng J, Wang J, Chen G, Li Q, Wang S, Wang Y, Wang
    S-S, Wang Y, Xuan W, Li Z, Guo Y, Gong Z, Friml J, Zhang J. 2022. Nitrate availability
    controls translocation of the transcription factor NAC075 for cell-type-specific
    reprogramming of root growth. Developmental Cell. 57(23), 2638–2651.e6.
  mla: Xiao, Huixin, et al. “Nitrate Availability Controls Translocation of the Transcription
    Factor NAC075 for Cell-Type-Specific Reprogramming of Root Growth.” <i>Developmental
    Cell</i>, vol. 57, no. 23, Elsevier, 2022, p. 2638–2651.e6, doi:<a href="https://doi.org/10.1016/j.devcel.2022.11.006">10.1016/j.devcel.2022.11.006</a>.
  short: H. Xiao, Y. Hu, Y. Wang, J. Cheng, J. Wang, G. Chen, Q. Li, S. Wang, Y. Wang,
    S.-S. Wang, Y. Wang, W. Xuan, Z. Li, Y. Guo, Z. Gong, J. Friml, J. Zhang, Developmental
    Cell 57 (2022) 2638–2651.e6.
date_created: 2023-01-12T11:57:00Z
date_published: 2022-12-05T00:00:00Z
date_updated: 2023-10-04T08:23:20Z
day: '05'
department:
- _id: JiFr
doi: 10.1016/j.devcel.2022.11.006
external_id:
  isi:
  - '000919603800005'
  pmid:
  - '36473460'
intvolume: '        57'
isi: 1
issue: '23'
keyword:
- Developmental Biology
- Cell Biology
- General Biochemistry
- Genetics and Molecular Biology
- Molecular Biology
language:
- iso: eng
month: '12'
oa_version: None
page: 2638-2651.e6
pmid: 1
publication: Developmental Cell
publication_identifier:
  issn:
  - 1534-5807
publication_status: published
publisher: Elsevier
quality_controlled: '1'
scopus_import: '1'
status: public
title: Nitrate availability controls translocation of the transcription factor NAC075
  for cell-type-specific reprogramming of root growth
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 57
year: '2022'
...
---
_id: '12121'
abstract:
- lang: eng
  text: Autophagosomes are double-membraned vesicles that traffic harmful or unwanted
    cellular macromolecules to the vacuole for recycling. Although autophagosome biogenesis
    has been extensively studied, autophagosome maturation, i.e., delivery and fusion
    with the vacuole, remains largely unknown in plants. Here, we have identified
    an autophagy adaptor, CFS1, that directly interacts with the autophagosome marker
    ATG8 and localizes on both membranes of the autophagosome. Autophagosomes form
    normally in Arabidopsis thaliana cfs1 mutants, but their delivery to the vacuole
    is disrupted. CFS1’s function is evolutionarily conserved in plants, as it also
    localizes to the autophagosomes and plays a role in autophagic flux in the liverwort
    Marchantia polymorpha. CFS1 regulates autophagic flux by bridging autophagosomes
    with the multivesicular body-localized ESCRT-I component VPS23A, leading to the
    formation of amphisomes. Similar to CFS1-ATG8 interaction, disrupting the CFS1-VPS23A
    interaction blocks autophagic flux and renders plants sensitive to nitrogen starvation.
    Altogether, our results reveal a conserved vacuolar sorting hub that regulates
    autophagic flux in plants.
acknowledgement: "We thank Suayip Ustün, Karin Schumacher, Erika Isono, Gerd Juergens,
  Takashi Ueda, Daniel Hofius, and Liwen Jiang for sharing published materials.\r\nWe
  acknowledge funding from Austrian Academy of Sciences, Austrian Science Fund (FWF,
  P 32355, P 34944), Austrian Science Fund (FWF-SFB F79), Vienna Science and Technology\r\nFund
  (WWTF, LS17-047) to Y. Dagdas; Austrian Academy of Sciences DOC Fellowship to J.
  Zhao, Marie Curie VIP2 Fellowship to J.C. De La Concepcion and M. Clavel; Hong Kong
  Research Grant Council (GRF14121019, 14113921, AoE/M-05/12, C4002-17G) to B.-H.
  Kang. We thank Vienna Biocenter Core Facilities (VBCF) Protein Chemistry, Biooptics,
  Plant Sciences, Molecular Biology, and Protein Technologies. We thank J. Matthew
  Watson\r\nand members of the Dagdas lab for the critical reading and editing of
  the manuscript."
article_number: e202203139
article_processing_charge: No
article_type: original
author:
- first_name: Jierui
  full_name: Zhao, Jierui
  last_name: Zhao
- first_name: Mai Thu
  full_name: Bui, Mai Thu
  last_name: Bui
- first_name: Juncai
  full_name: Ma, Juncai
  last_name: Ma
- first_name: Fabian
  full_name: Künzl, Fabian
  last_name: Künzl
- first_name: Lorenzo
  full_name: Picchianti, Lorenzo
  last_name: Picchianti
- first_name: Juan Carlos
  full_name: De La Concepcion, Juan Carlos
  last_name: De La Concepcion
- first_name: Yixuan
  full_name: Chen, Yixuan
  last_name: Chen
- first_name: Sofia
  full_name: Petsangouraki, Sofia
  last_name: Petsangouraki
- first_name: Azadeh
  full_name: Mohseni, Azadeh
  last_name: Mohseni
- first_name: Marta
  full_name: García-Leon, Marta
  last_name: García-Leon
- first_name: Marta Salas
  full_name: Gomez, Marta Salas
  last_name: Gomez
- first_name: Caterina
  full_name: Giannini, Caterina
  id: e3fdddd5-f6e0-11ea-865d-ca99ee6367f4
  last_name: Giannini
- first_name: Dubois
  full_name: Gwennogan, Dubois
  last_name: Gwennogan
- first_name: Roksolana
  full_name: Kobylinska, Roksolana
  last_name: Kobylinska
- first_name: Marion
  full_name: Clavel, Marion
  last_name: Clavel
- first_name: Swen
  full_name: Schellmann, Swen
  last_name: Schellmann
- first_name: Yvon
  full_name: Jaillais, Yvon
  last_name: Jaillais
- first_name: Jiří
  full_name: Friml, Jiří
  id: 4159519E-F248-11E8-B48F-1D18A9856A87
  last_name: Friml
  orcid: 0000-0002-8302-7596
- first_name: Byung-Ho
  full_name: Kang, Byung-Ho
  last_name: Kang
- first_name: Yasin
  full_name: Dagdas, Yasin
  last_name: Dagdas
citation:
  ama: Zhao J, Bui MT, Ma J, et al. Plant autophagosomes mature into amphisomes prior
    to their delivery to the central vacuole. <i>Journal of Cell Biology</i>. 2022;221(12).
    doi:<a href="https://doi.org/10.1083/jcb.202203139">10.1083/jcb.202203139</a>
  apa: Zhao, J., Bui, M. T., Ma, J., Künzl, F., Picchianti, L., De La Concepcion,
    J. C., … Dagdas, Y. (2022). Plant autophagosomes mature into amphisomes prior
    to their delivery to the central vacuole. <i>Journal of Cell Biology</i>. Rockefeller
    University Press. <a href="https://doi.org/10.1083/jcb.202203139">https://doi.org/10.1083/jcb.202203139</a>
  chicago: Zhao, Jierui, Mai Thu Bui, Juncai Ma, Fabian Künzl, Lorenzo Picchianti,
    Juan Carlos De La Concepcion, Yixuan Chen, et al. “Plant Autophagosomes Mature
    into Amphisomes Prior to Their Delivery to the Central Vacuole.” <i>Journal of
    Cell Biology</i>. Rockefeller University Press, 2022. <a href="https://doi.org/10.1083/jcb.202203139">https://doi.org/10.1083/jcb.202203139</a>.
  ieee: J. Zhao <i>et al.</i>, “Plant autophagosomes mature into amphisomes prior
    to their delivery to the central vacuole,” <i>Journal of Cell Biology</i>, vol.
    221, no. 12. Rockefeller University Press, 2022.
  ista: Zhao J, Bui MT, Ma J, Künzl F, Picchianti L, De La Concepcion JC, Chen Y,
    Petsangouraki S, Mohseni A, García-Leon M, Gomez MS, Giannini C, Gwennogan D,
    Kobylinska R, Clavel M, Schellmann S, Jaillais Y, Friml J, Kang B-H, Dagdas Y.
    2022. Plant autophagosomes mature into amphisomes prior to their delivery to the
    central vacuole. Journal of Cell Biology. 221(12), e202203139.
  mla: Zhao, Jierui, et al. “Plant Autophagosomes Mature into Amphisomes Prior to
    Their Delivery to the Central Vacuole.” <i>Journal of Cell Biology</i>, vol. 221,
    no. 12, e202203139, Rockefeller University Press, 2022, doi:<a href="https://doi.org/10.1083/jcb.202203139">10.1083/jcb.202203139</a>.
  short: J. Zhao, M.T. Bui, J. Ma, F. Künzl, L. Picchianti, J.C. De La Concepcion,
    Y. Chen, S. Petsangouraki, A. Mohseni, M. García-Leon, M.S. Gomez, C. Giannini,
    D. Gwennogan, R. Kobylinska, M. Clavel, S. Schellmann, Y. Jaillais, J. Friml,
    B.-H. Kang, Y. Dagdas, Journal of Cell Biology 221 (2022).
date_created: 2023-01-12T11:57:10Z
date_published: 2022-12-01T00:00:00Z
date_updated: 2023-08-03T14:20:15Z
day: '01'
ddc:
- '580'
department:
- _id: JiFr
doi: 10.1083/jcb.202203139
external_id:
  isi:
  - '000932958800001'
  pmid:
  - '36260289'
file:
- access_level: open_access
  checksum: 050b5cc4b25e6b94fe3e3cbfe0f5c06b
  content_type: application/pdf
  creator: dernst
  date_created: 2023-01-23T10:30:11Z
  date_updated: 2023-01-23T10:30:11Z
  file_id: '12342'
  file_name: 2022_JCB_Zhao.pdf
  file_size: 10365777
  relation: main_file
  success: 1
file_date_updated: 2023-01-23T10:30:11Z
has_accepted_license: '1'
intvolume: '       221'
isi: 1
issue: '12'
keyword:
- Cell Biology
language:
- iso: eng
month: '12'
oa: 1
oa_version: Published Version
pmid: 1
publication: Journal of Cell Biology
publication_identifier:
  eissn:
  - 1540-8140
  issn:
  - 0021-9525
publication_status: published
publisher: Rockefeller University Press
quality_controlled: '1'
scopus_import: '1'
status: public
title: Plant autophagosomes mature into amphisomes prior to their delivery to the
  central vacuole
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 221
year: '2022'
...
---
_id: '12122'
abstract:
- lang: eng
  text: Centrosomes play a crucial role during immune cell interactions and initiation
    of the immune response. In proliferating cells, centrosome numbers are tightly
    controlled and generally limited to one in G1 and two prior to mitosis. Defects
    in regulating centrosome numbers have been associated with cell transformation
    and tumorigenesis. Here, we report the emergence of extra centrosomes in leukocytes
    during immune activation. Upon antigen encounter, dendritic cells pass through
    incomplete mitosis and arrest in the subsequent G1 phase leading to tetraploid
    cells with accumulated centrosomes. In addition, cell stimulation increases expression
    of polo-like kinase 2, resulting in diploid cells with two centrosomes in G1-arrested
    cells. During cell migration, centrosomes tightly cluster and act as functional
    microtubule-organizing centers allowing for increased persistent locomotion along
    gradients of chemotactic cues. Moreover, dendritic cells with extra centrosomes
    display enhanced secretion of inflammatory cytokines and optimized T cell responses.
    Together, these results demonstrate a previously unappreciated role of extra centrosomes
    for regular cell and tissue homeostasis.
acknowledgement: "We thank Markéta Dalecká and Irena Krejzová for their support with
  FIB-SEM imaging, the Imaging Methods Core Facility at BIOCEV supported by the Ministry
  of Education, Youth and Sports Czech Republic (Large RI Project LM2018129 Czech-BioImaging),
  and European Regional Development Fund (project No. CZ.02.1.01/0.0/0.0/18_046/0016045)
  for their support with obtaining imaging data presented in this paper. The authors
  further thank Andreas Villunger, Florian Gärtner, Frank Bradke, and Sarah Förster
  for helpful discussions; Andy Zielinski for help with statistics; and Björn Weiershausen
  for assisting with figure illustration.\r\n\r\nThis work was funded by a fellowship
  of the Ministry of Innovation, Science and Research of North-Rhine-Westphalia (AZ:
  421-8.03.03.02-137069) to E. Kiermaier and the Deutsche Forschungsgemeinschaft (German
  Research Foundation) under Germany’s Excellence Strategy – EXC 2151 – 390873048.
  R. Hauschild was funded by grant number 2020-225401 from the Chan Zuckerberg Initiative
  Donor-Advised Fund, an advised fund of Silicon Valley Community Foundation. M. Hons
  is supported by Czech Science Foundation GACR 20-24603Y and Charles University PRIMUS/20/MED/013."
article_number: e202107134
article_processing_charge: No
article_type: original
author:
- first_name: Ann-Kathrin
  full_name: Weier, Ann-Kathrin
  last_name: Weier
- first_name: Mirka
  full_name: Homrich, Mirka
  last_name: Homrich
- first_name: Stephanie
  full_name: Ebbinghaus, Stephanie
  last_name: Ebbinghaus
- first_name: Pavel
  full_name: Juda, Pavel
  last_name: Juda
- first_name: Eliška
  full_name: Miková, Eliška
  last_name: Miková
- first_name: Robert
  full_name: Hauschild, Robert
  id: 4E01D6B4-F248-11E8-B48F-1D18A9856A87
  last_name: Hauschild
  orcid: 0000-0001-9843-3522
- first_name: Lili
  full_name: Zhang, Lili
  last_name: Zhang
- first_name: Thomas
  full_name: Quast, Thomas
  last_name: Quast
- first_name: Elvira
  full_name: Mass, Elvira
  last_name: Mass
- first_name: Andreas
  full_name: Schlitzer, Andreas
  last_name: Schlitzer
- first_name: Waldemar
  full_name: Kolanus, Waldemar
  last_name: Kolanus
- first_name: Sven
  full_name: Burgdorf, Sven
  last_name: Burgdorf
- first_name: Oliver J.
  full_name: Gruß, Oliver J.
  last_name: Gruß
- first_name: Miroslav
  full_name: Hons, Miroslav
  last_name: Hons
- first_name: Stefan
  full_name: Wieser, Stefan
  last_name: Wieser
- first_name: Eva
  full_name: Kiermaier, Eva
  last_name: Kiermaier
citation:
  ama: Weier A-K, Homrich M, Ebbinghaus S, et al. Multiple centrosomes enhance migration
    and immune cell effector functions of mature dendritic cells. <i>Journal of Cell
    Biology</i>. 2022;221(12). doi:<a href="https://doi.org/10.1083/jcb.202107134">10.1083/jcb.202107134</a>
  apa: Weier, A.-K., Homrich, M., Ebbinghaus, S., Juda, P., Miková, E., Hauschild,
    R., … Kiermaier, E. (2022). Multiple centrosomes enhance migration and immune
    cell effector functions of mature dendritic cells. <i>Journal of Cell Biology</i>.
    Rockefeller University Press. <a href="https://doi.org/10.1083/jcb.202107134">https://doi.org/10.1083/jcb.202107134</a>
  chicago: Weier, Ann-Kathrin, Mirka Homrich, Stephanie Ebbinghaus, Pavel Juda, Eliška
    Miková, Robert Hauschild, Lili Zhang, et al. “Multiple Centrosomes Enhance Migration
    and Immune Cell Effector Functions of Mature Dendritic Cells.” <i>Journal of Cell
    Biology</i>. Rockefeller University Press, 2022. <a href="https://doi.org/10.1083/jcb.202107134">https://doi.org/10.1083/jcb.202107134</a>.
  ieee: A.-K. Weier <i>et al.</i>, “Multiple centrosomes enhance migration and immune
    cell effector functions of mature dendritic cells,” <i>Journal of Cell Biology</i>,
    vol. 221, no. 12. Rockefeller University Press, 2022.
  ista: Weier A-K, Homrich M, Ebbinghaus S, Juda P, Miková E, Hauschild R, Zhang L,
    Quast T, Mass E, Schlitzer A, Kolanus W, Burgdorf S, Gruß OJ, Hons M, Wieser S,
    Kiermaier E. 2022. Multiple centrosomes enhance migration and immune cell effector
    functions of mature dendritic cells. Journal of Cell Biology. 221(12), e202107134.
  mla: Weier, Ann-Kathrin, et al. “Multiple Centrosomes Enhance Migration and Immune
    Cell Effector Functions of Mature Dendritic Cells.” <i>Journal of Cell Biology</i>,
    vol. 221, no. 12, e202107134, Rockefeller University Press, 2022, doi:<a href="https://doi.org/10.1083/jcb.202107134">10.1083/jcb.202107134</a>.
  short: A.-K. Weier, M. Homrich, S. Ebbinghaus, P. Juda, E. Miková, R. Hauschild,
    L. Zhang, T. Quast, E. Mass, A. Schlitzer, W. Kolanus, S. Burgdorf, O.J. Gruß,
    M. Hons, S. Wieser, E. Kiermaier, Journal of Cell Biology 221 (2022).
date_created: 2023-01-12T12:01:09Z
date_published: 2022-12-05T00:00:00Z
date_updated: 2023-08-16T11:29:12Z
day: '05'
ddc:
- '570'
department:
- _id: Bio
doi: 10.1083/jcb.202107134
external_id:
  isi:
  - '000932941400001'
  pmid:
  - '36214847 '
file:
- access_level: open_access
  checksum: 0c9af38f82af30c6ce528f2caece4246
  content_type: application/pdf
  creator: dernst
  date_created: 2023-08-16T11:24:53Z
  date_updated: 2023-08-16T11:24:53Z
  file_id: '14065'
  file_name: 2023_JCB_Weier.pdf
  file_size: 11090179
  relation: main_file
  success: 1
file_date_updated: 2023-08-16T11:24:53Z
has_accepted_license: '1'
intvolume: '       221'
isi: 1
issue: '12'
keyword:
- Cell Biology
language:
- iso: eng
license: https://creativecommons.org/licenses/by-nc-sa/4.0/
month: '12'
oa: 1
oa_version: Published Version
pmid: 1
project:
- _id: c08e9ad1-5a5b-11eb-8a69-9d1cf3b07473
  grant_number: CZI01
  name: Tools for automation and feedback microscopy
publication: Journal of Cell Biology
publication_identifier:
  eissn:
  - 1540-8140
  issn:
  - 0021-9525
publication_status: published
publisher: Rockefeller University Press
quality_controlled: '1'
scopus_import: '1'
status: public
title: Multiple centrosomes enhance migration and immune cell effector functions of
  mature dendritic cells
tmp:
  image: /images/cc_by_nc_sa.png
  legal_code_url: https://creativecommons.org/licenses/by-nc-sa/4.0/legalcode
  name: Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC
    BY-NC-SA 4.0)
  short: CC BY-NC-SA (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 221
year: '2022'
...
---
_id: '12128'
abstract:
- lang: eng
  text: We introduce a machine-learning (ML) framework for high-throughput benchmarking
    of diverse representations of chemical systems against datasets of materials and
    molecules. The guiding principle underlying the benchmarking approach is to evaluate
    raw descriptor performance by limiting model complexity to simple regression schemes
    while enforcing best ML practices, allowing for unbiased hyperparameter optimization,
    and assessing learning progress through learning curves along series of synchronized
    train-test splits. The resulting models are intended as baselines that can inform
    future method development, in addition to indicating how easily a given dataset
    can be learnt. Through a comparative analysis of the training outcome across a
    diverse set of physicochemical, topological and geometric representations, we
    glean insight into the relative merits of these representations as well as their
    interrelatedness.
acknowledgement: 'C P acknowledges funding from Astex through the Sustaining Innovation
  Program under the Milner Consortium. B C acknowledges resources provided by the
  Cambridge Tier-2 system operated by the University of Cambridge Research Computing
  Service funded by EPSRC Tier-2 capital Grant EP/P020259/1. F A F acknowledges funding
  from the Swiss National Science Foundation (Grant No. P2BSP2_191736). '
article_number: '040501'
article_processing_charge: No
article_type: original
author:
- first_name: Carl
  full_name: Poelking, Carl
  last_name: Poelking
- first_name: Felix A
  full_name: Faber, Felix A
  last_name: Faber
- first_name: Bingqing
  full_name: Cheng, Bingqing
  id: cbe3cda4-d82c-11eb-8dc7-8ff94289fcc9
  last_name: Cheng
  orcid: 0000-0002-3584-9632
citation:
  ama: 'Poelking C, Faber FA, Cheng B. BenchML: An extensible pipelining framework
    for benchmarking representations of materials and molecules at scale. <i>Machine
    Learning: Science and Technology</i>. 2022;3(4). doi:<a href="https://doi.org/10.1088/2632-2153/ac4d11">10.1088/2632-2153/ac4d11</a>'
  apa: 'Poelking, C., Faber, F. A., &#38; Cheng, B. (2022). BenchML: An extensible
    pipelining framework for benchmarking representations of materials and molecules
    at scale. <i>Machine Learning: Science and Technology</i>. IOP Publishing. <a
    href="https://doi.org/10.1088/2632-2153/ac4d11">https://doi.org/10.1088/2632-2153/ac4d11</a>'
  chicago: 'Poelking, Carl, Felix A Faber, and Bingqing Cheng. “BenchML: An Extensible
    Pipelining Framework for Benchmarking Representations of Materials and Molecules
    at Scale.” <i>Machine Learning: Science and Technology</i>. IOP Publishing, 2022.
    <a href="https://doi.org/10.1088/2632-2153/ac4d11">https://doi.org/10.1088/2632-2153/ac4d11</a>.'
  ieee: 'C. Poelking, F. A. Faber, and B. Cheng, “BenchML: An extensible pipelining
    framework for benchmarking representations of materials and molecules at scale,”
    <i>Machine Learning: Science and Technology</i>, vol. 3, no. 4. IOP Publishing,
    2022.'
  ista: 'Poelking C, Faber FA, Cheng B. 2022. BenchML: An extensible pipelining framework
    for benchmarking representations of materials and molecules at scale. Machine
    Learning: Science and Technology. 3(4), 040501.'
  mla: 'Poelking, Carl, et al. “BenchML: An Extensible Pipelining Framework for Benchmarking
    Representations of Materials and Molecules at Scale.” <i>Machine Learning: Science
    and Technology</i>, vol. 3, no. 4, 040501, IOP Publishing, 2022, doi:<a href="https://doi.org/10.1088/2632-2153/ac4d11">10.1088/2632-2153/ac4d11</a>.'
  short: 'C. Poelking, F.A. Faber, B. Cheng, Machine Learning: Science and Technology
    3 (2022).'
date_created: 2023-01-12T12:02:21Z
date_published: 2022-11-17T00:00:00Z
date_updated: 2023-08-04T08:49:53Z
day: '17'
ddc:
- '000'
department:
- _id: BiCh
doi: 10.1088/2632-2153/ac4d11
external_id:
  isi:
  - '000886534000001'
file:
- access_level: open_access
  checksum: 8930d4ad6ed9b47358c6f1a68666adb6
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  creator: dernst
  date_created: 2023-01-23T10:42:04Z
  date_updated: 2023-01-23T10:42:04Z
  file_id: '12343'
  file_name: 2022_MachLearning_Poelking.pdf
  file_size: 13814559
  relation: main_file
  success: 1
file_date_updated: 2023-01-23T10:42:04Z
has_accepted_license: '1'
intvolume: '         3'
isi: 1
issue: '4'
keyword:
- Artificial Intelligence
- Human-Computer Interaction
- Software
language:
- iso: eng
month: '11'
oa: 1
oa_version: Published Version
publication: 'Machine Learning: Science and Technology'
publication_identifier:
  issn:
  - 2632-2153
publication_status: published
publisher: IOP Publishing
quality_controlled: '1'
related_material:
  link:
  - relation: software
    url: https://github.com/capoe/benchml
scopus_import: '1'
status: public
title: 'BenchML: An extensible pipelining framework for benchmarking representations
  of materials and molecules at scale'
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 3
year: '2022'
...
---
_id: '12129'
abstract:
- lang: eng
  text: 'Given a finite point set P in general position in the plane, a full triangulation
    of P is a maximal straight-line embedded plane graph on P. A partial triangulation
    of P is a full triangulation of some subset P′ of P containing all extreme points
    in P. A bistellar flip on a partial triangulation either flips an edge (called
    edge flip), removes a non-extreme point of degree 3, or adds a point in P∖P′ as
    vertex of degree 3. The bistellar flip graph has all partial triangulations as
    vertices, and a pair of partial triangulations is adjacent if they can be obtained
    from one another by a bistellar flip. The edge flip graph is defined with full
    triangulations as vertices, and edge flips determining the adjacencies. Lawson
    showed in the early seventies that these graphs are connected. The goal of this
    paper is to investigate the structure of these graphs, with emphasis on their
    vertex connectivity. For sets P of n points in the plane in general position,
    we show that the edge flip graph is ⌈n/2−2⌉-vertex connected, and the bistellar
    flip graph is (n−3)-vertex connected; both results are tight. The latter bound
    matches the situation for the subfamily of regular triangulations (i.e., partial
    triangulations obtained by lifting the points to 3-space and projecting back the
    lower convex hull), where (n−3)-vertex connectivity has been known since the late
    eighties through the secondary polytope due to Gelfand, Kapranov, & Zelevinsky
    and Balinski’s Theorem. For the edge flip-graph, we additionally show that the
    vertex connectivity is at least as large as (and hence equal to) the minimum degree
    (i.e., the minimum number of flippable edges in any full triangulation), provided
    that n is large enough. Our methods also yield several other results: (i) The
    edge flip graph can be covered by graphs of polytopes of dimension ⌈n/2−2⌉ (products
    of associahedra) and the bistellar flip graph can be covered by graphs of polytopes
    of dimension n−3 (products of secondary polytopes). (ii) A partial triangulation
    is regular, if it has distance n−3 in the Hasse diagram of the partial order of
    partial subdivisions from the trivial subdivision. (iii) All partial triangulations
    of a point set are regular iff the partial order of partial subdivisions has height
    n−3. (iv) There are arbitrarily large sets P with non-regular partial triangulations
    and such that every proper subset has only regular triangulations, i.e., there
    are no small certificates for the existence of non-regular triangulations.'
acknowledgement: "This is a full and revised version of [38] (on partial triangulations)
  in Proceedings of the 36th Annual International Symposium on Computational Geometry
  (SoCG‘20) and of some of the results in [37] (on full triangulations) in Proceedings
  of the 31st Annual ACM-SIAM Symposium on Discrete Algorithms (SODA‘20).\r\nThis
  research started at the 11th Gremo’s Workshop on Open Problems (GWOP), Alp Sellamatt,
  Switzerland, June 24–28, 2013, motivated by a question posed by Filip Mori´c on
  full triangulations. Research was supported by the Swiss National Science Foundation
  within the collaborative DACH project Arrangements and Drawings as SNSF Project
  200021E-171681, and by IST Austria and Berlin Free University during a sabbatical
  stay of the second author. We thank Michael Joswig, Jesús De Loera, and Francisco
  Santos for helpful discussions on the topics of this paper, and Daniel Bertschinger
  and Valentin Stoppiello for carefully reading earlier versions and for many helpful
  comments.\r\nOpen access funding provided by the Swiss Federal Institute of Technology
  Zürich"
article_processing_charge: No
article_type: original
author:
- first_name: Uli
  full_name: Wagner, Uli
  id: 36690CA2-F248-11E8-B48F-1D18A9856A87
  last_name: Wagner
  orcid: 0000-0002-1494-0568
- first_name: Emo
  full_name: Welzl, Emo
  last_name: Welzl
citation:
  ama: Wagner U, Welzl E. Connectivity of triangulation flip graphs in the plane.
    <i>Discrete &#38; Computational Geometry</i>. 2022;68(4):1227-1284. doi:<a href="https://doi.org/10.1007/s00454-022-00436-2">10.1007/s00454-022-00436-2</a>
  apa: Wagner, U., &#38; Welzl, E. (2022). Connectivity of triangulation flip graphs
    in the plane. <i>Discrete &#38; Computational Geometry</i>. Springer Nature. <a
    href="https://doi.org/10.1007/s00454-022-00436-2">https://doi.org/10.1007/s00454-022-00436-2</a>
  chicago: Wagner, Uli, and Emo Welzl. “Connectivity of Triangulation Flip Graphs
    in the Plane.” <i>Discrete &#38; Computational Geometry</i>. Springer Nature,
    2022. <a href="https://doi.org/10.1007/s00454-022-00436-2">https://doi.org/10.1007/s00454-022-00436-2</a>.
  ieee: U. Wagner and E. Welzl, “Connectivity of triangulation flip graphs in the
    plane,” <i>Discrete &#38; Computational Geometry</i>, vol. 68, no. 4. Springer
    Nature, pp. 1227–1284, 2022.
  ista: Wagner U, Welzl E. 2022. Connectivity of triangulation flip graphs in the
    plane. Discrete &#38; Computational Geometry. 68(4), 1227–1284.
  mla: Wagner, Uli, and Emo Welzl. “Connectivity of Triangulation Flip Graphs in the
    Plane.” <i>Discrete &#38; Computational Geometry</i>, vol. 68, no. 4, Springer
    Nature, 2022, pp. 1227–84, doi:<a href="https://doi.org/10.1007/s00454-022-00436-2">10.1007/s00454-022-00436-2</a>.
  short: U. Wagner, E. Welzl, Discrete &#38; Computational Geometry 68 (2022) 1227–1284.
date_created: 2023-01-12T12:02:28Z
date_published: 2022-11-14T00:00:00Z
date_updated: 2023-08-04T08:51:08Z
day: '14'
ddc:
- '510'
department:
- _id: UlWa
doi: 10.1007/s00454-022-00436-2
external_id:
  isi:
  - '000883222200003'
file:
- access_level: open_access
  checksum: 307e879d09e52eddf5b225d0aaa9213a
  content_type: application/pdf
  creator: dernst
  date_created: 2023-01-23T11:10:03Z
  date_updated: 2023-01-23T11:10:03Z
  file_id: '12345'
  file_name: 2022_DiscreteCompGeometry_Wagner.pdf
  file_size: 1747581
  relation: main_file
  success: 1
file_date_updated: 2023-01-23T11:10:03Z
has_accepted_license: '1'
intvolume: '        68'
isi: 1
issue: '4'
keyword:
- Computational Theory and Mathematics
- Discrete Mathematics and Combinatorics
- Geometry and Topology
- Theoretical Computer Science
language:
- iso: eng
month: '11'
oa: 1
oa_version: Published Version
page: 1227-1284
publication: Discrete & Computational Geometry
publication_identifier:
  eissn:
  - 1432-0444
  issn:
  - 0179-5376
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
related_material:
  record:
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    relation: earlier_version
    status: public
  - id: '7990'
    relation: earlier_version
    status: public
scopus_import: '1'
status: public
title: Connectivity of triangulation flip graphs in the plane
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 68
year: '2022'
...
