[{"year":"2011","doi":"10.1016/j.tree.2011.04.002","month":"08","language":[{"iso":"eng"}],"intvolume":"        26","publication_status":"published","date_updated":"2021-01-12T07:43:10Z","type":"journal_article","ec_funded":1,"author":[{"orcid":"0000-0002-5985-7653","last_name":"de Vladar","first_name":"Harold","full_name":"de Vladar, Harold","id":"2A181218-F248-11E8-B48F-1D18A9856A87"},{"full_name":"Barton, Nicholas H","last_name":"Barton","orcid":"0000-0002-8548-5240","first_name":"Nicholas H","id":"4880FE40-F248-11E8-B48F-1D18A9856A87"}],"abstract":[{"text":"Evolutionary biology shares many concepts with statistical physics: both deal with populations, whether of molecules or organisms, and both seek to simplify evolution in very many dimensions. Often, methodologies have undergone parallel and independent development, as with stochastic methods in population genetics. Here, we discuss aspects of population genetics that have embraced methods from physics: non-equilibrium statistical mechanics, travelling waves and Monte-Carlo methods, among others, have been used to study polygenic evolution, rates of adaptation and range expansions. These applications indicate that evolutionary biology can further benefit from interactions with other areas of statistical physics; for example, by following the distribution of paths taken by a population through time","lang":"eng"}],"issue":"8","scopus_import":1,"date_published":"2011-08-01T00:00:00Z","date_created":"2018-12-11T12:03:04Z","_id":"3391","publist_id":"3216","project":[{"name":"Limits to selection in biology and in evolutionary computation","_id":"25B07788-B435-11E9-9278-68D0E5697425","grant_number":"250152","call_identifier":"FP7"}],"publication":"Trends in Ecology and Evolution","title":"The contribution of statistical physics to evolutionary biology","status":"public","department":[{"_id":"NiBa"}],"user_id":"4435EBFC-F248-11E8-B48F-1D18A9856A87","publisher":"Cell Press","quality_controlled":"1","day":"01","citation":{"ieee":"H. de Vladar and N. H. Barton, “The contribution of statistical physics to evolutionary biology,” <i>Trends in Ecology and Evolution</i>, vol. 26, no. 8. Cell Press, pp. 424–432, 2011.","chicago":"Vladar, Harold de, and Nicholas H Barton. “The Contribution of Statistical Physics to Evolutionary Biology.” <i>Trends in Ecology and Evolution</i>. Cell Press, 2011. <a href=\"https://doi.org/10.1016/j.tree.2011.04.002\">https://doi.org/10.1016/j.tree.2011.04.002</a>.","short":"H. de Vladar, N.H. Barton, Trends in Ecology and Evolution 26 (2011) 424–432.","ista":"de Vladar H, Barton NH. 2011. The contribution of statistical physics to evolutionary biology. Trends in Ecology and Evolution. 26(8), 424–432.","ama":"de Vladar H, Barton NH. The contribution of statistical physics to evolutionary biology. <i>Trends in Ecology and Evolution</i>. 2011;26(8):424-432. doi:<a href=\"https://doi.org/10.1016/j.tree.2011.04.002\">10.1016/j.tree.2011.04.002</a>","mla":"de Vladar, Harold, and Nicholas H. Barton. “The Contribution of Statistical Physics to Evolutionary Biology.” <i>Trends in Ecology and Evolution</i>, vol. 26, no. 8, Cell Press, 2011, pp. 424–32, doi:<a href=\"https://doi.org/10.1016/j.tree.2011.04.002\">10.1016/j.tree.2011.04.002</a>.","apa":"de Vladar, H., &#38; Barton, N. H. (2011). The contribution of statistical physics to evolutionary biology. <i>Trends in Ecology and Evolution</i>. Cell Press. <a href=\"https://doi.org/10.1016/j.tree.2011.04.002\">https://doi.org/10.1016/j.tree.2011.04.002</a>"},"oa":1,"main_file_link":[{"open_access":"1","url":"http://arxiv.org/abs/1104.2854"}],"oa_version":"Submitted Version","volume":26,"page":"424 - 432"},{"issue":"5","author":[{"full_name":"Soriano, Silvia","last_name":"Soriano","first_name":"Silvia"},{"full_name":"Hons, Miroslav","first_name":"Miroslav","orcid":"0000-0002-6625-3348","last_name":"Hons"},{"first_name":"Kathrin","last_name":"Schumann","full_name":"Schumann, Kathrin"},{"last_name":"Kumar","first_name":"Varsha","full_name":"Kumar, Varsha"},{"first_name":"Timo","last_name":"Dennier","full_name":"Dennier, Timo"},{"first_name":"Ruth","last_name":"Lyck","full_name":"Lyck, Ruth"},{"full_name":"Sixt, Michael K","orcid":"0000-0002-6620-9179","last_name":"Sixt","first_name":"Michael K","id":"41E9FBEA-F248-11E8-B48F-1D18A9856A87"},{"full_name":"Stein, Jens","last_name":"Stein","first_name":"Jens"}],"abstract":[{"text":"Migrating lymphocytes acquire a polarized phenotype with a leading and a trailing edge, or uropod. Although in vitro experiments in cell lines or activated primary cell cultures have established that Rho-p160 coiled-coil kinase (ROCK)-myosin II-mediated uropod contractility is required for integrin de-adhesion on two-dimensional surfaces and nuclear propulsion through narrow pores in three-dimensional matrices, less is known about the role of these two events during the recirculation of primary, nonactivated lymphocytes. Using pharmacological antagonists of ROCK and myosin II, we report that inhibition of uropod contractility blocked integrin-independent mouse T cell migration through narrow, but not large, pores in vitro. T cell crawling on chemokine-coated endothelial cells under shear was severely impaired by ROCK inhibition, whereas transendothelial migration was only reduced through endothelial cells with high, but not low, barrier properties. Using three-dimensional thick-tissue imaging and dynamic two-photon microscopy of T cell motility in lymphoid tissue, we demonstrated a significant role for uropod contractility in intraluminal crawling and transendothelial migration through lymph node, but not bone marrow, endothelial cells. Finally, we demonstrated that ICAM-1, but not anatomical constraints or integrin-independent interactions, reduced parenchymal motility of inhibitor-treated T cells within the dense lymphoid microenvironment, thus assigning context-dependent roles for uropod contraction during lymphocyte recirculation.","lang":"eng"}],"date_published":"2011-09-01T00:00:00Z","scopus_import":"1","_id":"3392","date_created":"2018-12-11T12:03:04Z","doi":"10.4049/jimmunol.1100935","year":"2011","language":[{"iso":"eng"}],"month":"09","publication_status":"published","intvolume":"       187","type":"journal_article","date_updated":"2023-10-10T13:14:59Z","publication_identifier":{"eissn":["1550-6606"],"issn":["0022-1767"]},"quality_controlled":"1","citation":{"chicago":"Soriano, Silvia, Miroslav Hons, Kathrin Schumann, Varsha Kumar, Timo Dennier, Ruth Lyck, Michael K Sixt, and Jens Stein. “In Vivo Analysis of Uropod Function during Physiological T Cell Trafficking.” <i>Journal of Immunology</i>. American Association of Immunologists, 2011. <a href=\"https://doi.org/10.4049/jimmunol.1100935\">https://doi.org/10.4049/jimmunol.1100935</a>.","ieee":"S. Soriano <i>et al.</i>, “In vivo analysis of uropod function during physiological T cell trafficking,” <i>Journal of Immunology</i>, vol. 187, no. 5. American Association of Immunologists, pp. 2356–2364, 2011.","short":"S. Soriano, M. Hons, K. Schumann, V. Kumar, T. Dennier, R. Lyck, M.K. Sixt, J. Stein, Journal of Immunology 187 (2011) 2356–2364.","ista":"Soriano S, Hons M, Schumann K, Kumar V, Dennier T, Lyck R, Sixt MK, Stein J. 2011. In vivo analysis of uropod function during physiological T cell trafficking. Journal of Immunology. 187(5), 2356–2364.","apa":"Soriano, S., Hons, M., Schumann, K., Kumar, V., Dennier, T., Lyck, R., … Stein, J. (2011). In vivo analysis of uropod function during physiological T cell trafficking. <i>Journal of Immunology</i>. American Association of Immunologists. <a href=\"https://doi.org/10.4049/jimmunol.1100935\">https://doi.org/10.4049/jimmunol.1100935</a>","mla":"Soriano, Silvia, et al. “In Vivo Analysis of Uropod Function during Physiological T Cell Trafficking.” <i>Journal of Immunology</i>, vol. 187, no. 5, American Association of Immunologists, 2011, pp. 2356–64, doi:<a href=\"https://doi.org/10.4049/jimmunol.1100935\">10.4049/jimmunol.1100935</a>.","ama":"Soriano S, Hons M, Schumann K, et al. In vivo analysis of uropod function during physiological T cell trafficking. <i>Journal of Immunology</i>. 2011;187(5):2356-2364. doi:<a href=\"https://doi.org/10.4049/jimmunol.1100935\">10.4049/jimmunol.1100935</a>"},"day":"01","page":"2356 - 2364","volume":187,"oa_version":"None","article_type":"original","publist_id":"3215","article_processing_charge":"No","publication":"Journal of Immunology","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","department":[{"_id":"MiSi"}],"status":"public","title":"In vivo analysis of uropod function during physiological T cell trafficking","publisher":"American Association of Immunologists"},{"issue":"3","author":[{"orcid":"0000-0002-8548-5240","last_name":"Barton","first_name":"Nicholas H","full_name":"Barton, Nicholas H","id":"4880FE40-F248-11E8-B48F-1D18A9856A87"},{"full_name":"Turelli, Michael","first_name":"Michael","last_name":"Turelli"}],"abstract":[{"text":"Unlike unconditionally advantageous “Fisherian” variants that tend to spread throughout a species range once introduced anywhere, “bistable” variants, such as chromosome translocations, have two alternative stable frequencies, absence and (near) fixation. Analogous to populations with Allee effects, bistable variants tend to increase locally only once they become sufficiently common, and their spread depends on their rate of increase averaged over all frequencies. Several proposed manipulations of insect populations, such as using Wolbachia or “engineered underdominance” to suppress vector-borne diseases, produce bistable rather than Fisherian dynamics. We synthesize and extend theoretical analyses concerning three features of their spatial behavior: rate of spread, conditions to initiate spread from a localized introduction, and wave stopping caused by variation in population densities or dispersal rates. Unlike Fisherian variants, bistable variants tend to spread spatially only for particular parameter combinations and initial conditions. Wave initiation requires introduction over an extended region, while subsequent spatial spread is slower than for Fisherian waves and can easily be halted by local spatial inhomogeneities. We present several new results, including robust sufficient conditions to initiate (and stop) spread, using a one-parameter cubic approximation applicable to several models. The results have both basic and applied implications.","lang":"eng"}],"pubrep_id":"554","date_published":"2011-09-01T00:00:00Z","scopus_import":"1","_id":"3393","date_created":"2018-12-11T12:03:05Z","ddc":["570"],"doi":"10.1086/661246","year":"2011","language":[{"iso":"eng"}],"month":"09","publication_status":"published","intvolume":"       178","type":"journal_article","date_updated":"2023-10-18T08:01:43Z","publication_identifier":{"issn":["0003-0147"],"eissn":["1537-5323"]},"quality_controlled":"1","oa":1,"citation":{"ista":"Barton NH, Turelli M. 2011. Spatial waves of advance with bistable dynamics: Cytoplasmic and genetic analogues of Allee effects. American Naturalist. 178(3), E48–E75.","apa":"Barton, N. H., &#38; Turelli, M. (2011). Spatial waves of advance with bistable dynamics: Cytoplasmic and genetic analogues of Allee effects. <i>American Naturalist</i>. The University of Chicago Press. <a href=\"https://doi.org/10.1086/661246\">https://doi.org/10.1086/661246</a>","mla":"Barton, Nicholas H., and Michael Turelli. “Spatial Waves of Advance with Bistable Dynamics: Cytoplasmic and Genetic Analogues of Allee Effects.” <i>American Naturalist</i>, vol. 178, no. 3, The University of Chicago Press, 2011, pp. E48–75, doi:<a href=\"https://doi.org/10.1086/661246\">10.1086/661246</a>.","ama":"Barton NH, Turelli M. Spatial waves of advance with bistable dynamics: Cytoplasmic and genetic analogues of Allee effects. <i>American Naturalist</i>. 2011;178(3):E48-E75. doi:<a href=\"https://doi.org/10.1086/661246\">10.1086/661246</a>","ieee":"N. H. Barton and M. Turelli, “Spatial waves of advance with bistable dynamics: Cytoplasmic and genetic analogues of Allee effects,” <i>American Naturalist</i>, vol. 178, no. 3. The University of Chicago Press, pp. E48–E75, 2011.","chicago":"Barton, Nicholas H, and Michael Turelli. “Spatial Waves of Advance with Bistable Dynamics: Cytoplasmic and Genetic Analogues of Allee Effects.” <i>American Naturalist</i>. The University of Chicago Press, 2011. <a href=\"https://doi.org/10.1086/661246\">https://doi.org/10.1086/661246</a>.","short":"N.H. Barton, M. Turelli, American Naturalist 178 (2011) E48–E75."},"day":"01","volume":178,"page":"E48 - E75","oa_version":"Submitted Version","article_type":"original","file":[{"date_updated":"2020-07-14T12:46:11Z","date_created":"2018-12-12T10:08:31Z","access_level":"open_access","checksum":"7fd22a2ef3321a6fca6a439b3be5d8f4","file_size":629130,"creator":"system","file_id":"4692","content_type":"application/pdf","relation":"main_file","file_name":"IST-2016-554-v1+1_BartonTurelli2011_copy.pdf"}],"publist_id":"3214","article_processing_charge":"No","publication":"American Naturalist","file_date_updated":"2020-07-14T12:46:11Z","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","title":"Spatial waves of advance with bistable dynamics: Cytoplasmic and genetic analogues of Allee effects","has_accepted_license":"1","department":[{"_id":"NiBa"}],"status":"public","publisher":"The University of Chicago Press"},{"scopus_import":1,"date_published":"2011-09-01T00:00:00Z","date_created":"2018-12-11T12:03:05Z","_id":"3394","ec_funded":1,"abstract":[{"lang":"eng","text":"Random genetic drift shifts clines in space, alters their width, and distorts their shape. Such random fluctuations complicate inferences from cline width and position. Notably, the effect of genetic drift on the expected shape of the cline is opposite to the naive (but quite common) misinterpretation of classic results on the expected cline. While random drift on average broadens the overall cline in expected allele frequency, it narrows the width of any particular cline. The opposing effects arise because locally, drift drives alleles to fixation—but fluctuations in position widen the expected cline. The effect of genetic drift can be predicted from standardized variance in allele frequencies, averaged across the habitat: 〈F〉. A cline maintained by spatially varying selection (step change) is expected to be narrower by a factor of  relative to the cline in the absence of drift. The expected cline is broader by the inverse of this factor. In a tension zone maintained by underdominance, the expected cline width is narrower by about 1 – 〈F〉relative to the width in the absence of drift. Individual clines can differ substantially from the expectation, and we give quantitative predictions for the variance in cline position and width. The predictions apply to clines in almost one-dimensional circumstances such as hybrid zones in rivers, deep valleys, or along a coast line and give a guide to what patterns to expect in two dimensions."}],"author":[{"first_name":"Jitka","last_name":"Polechova","orcid":"0000-0003-0951-3112","full_name":"Polechova, Jitka","id":"3BBFB084-F248-11E8-B48F-1D18A9856A87"},{"first_name":"Nicholas H","last_name":"Barton","orcid":"0000-0002-8548-5240","full_name":"Barton, Nicholas H","id":"4880FE40-F248-11E8-B48F-1D18A9856A87"}],"issue":"1","intvolume":"       189","publication_status":"published","date_updated":"2021-01-12T07:43:11Z","type":"journal_article","year":"2011","doi":"10.1534/genetics.111.129817","month":"09","language":[{"iso":"eng"}],"main_file_link":[{"open_access":"1","url":"http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3176109/"}],"oa_version":"Submitted Version","page":"227 - 235","volume":189,"quality_controlled":"1","day":"01","citation":{"short":"J. Polechova, N.H. Barton, Genetics 189 (2011) 227–235.","chicago":"Polechova, Jitka, and Nicholas H Barton. “Genetic Drift Widens the Expected Cline but Narrows the Expected Cline Width.” <i>Genetics</i>. Genetics Society of America, 2011. <a href=\"https://doi.org/10.1534/genetics.111.129817\">https://doi.org/10.1534/genetics.111.129817</a>.","ieee":"J. Polechova and N. H. Barton, “Genetic drift widens the expected cline but narrows the expected cline width,” <i>Genetics</i>, vol. 189, no. 1. Genetics Society of America, pp. 227–235, 2011.","ama":"Polechova J, Barton NH. Genetic drift widens the expected cline but narrows the expected cline width. <i>Genetics</i>. 2011;189(1):227-235. doi:<a href=\"https://doi.org/10.1534/genetics.111.129817\">10.1534/genetics.111.129817</a>","mla":"Polechova, Jitka, and Nicholas H. Barton. “Genetic Drift Widens the Expected Cline but Narrows the Expected Cline Width.” <i>Genetics</i>, vol. 189, no. 1, Genetics Society of America, 2011, pp. 227–35, doi:<a href=\"https://doi.org/10.1534/genetics.111.129817\">10.1534/genetics.111.129817</a>.","apa":"Polechova, J., &#38; Barton, N. H. (2011). Genetic drift widens the expected cline but narrows the expected cline width. <i>Genetics</i>. Genetics Society of America. <a href=\"https://doi.org/10.1534/genetics.111.129817\">https://doi.org/10.1534/genetics.111.129817</a>","ista":"Polechova J, Barton NH. 2011. Genetic drift widens the expected cline but narrows the expected cline width. Genetics. 189(1), 227–235."},"oa":1,"department":[{"_id":"NiBa"}],"title":"Genetic drift widens the expected cline but narrows the expected cline width","status":"public","user_id":"4435EBFC-F248-11E8-B48F-1D18A9856A87","publisher":"Genetics Society of America","publist_id":"3213","project":[{"name":"Limits to selection in biology and in evolutionary computation","grant_number":"250152","call_identifier":"FP7","_id":"25B07788-B435-11E9-9278-68D0E5697425"}],"publication":"Genetics"},{"year":"2011","doi":"10.1111/j.1095-8312.2011.01728.x","language":[{"iso":"eng"}],"month":"09","intvolume":"       104","publication_status":"published","date_updated":"2023-02-23T14:07:31Z","type":"journal_article","issue":"2","author":[{"id":"3F0E2A22-F248-11E8-B48F-1D18A9856A87","first_name":"Ferran","orcid":"0000-0002-0343-8329","last_name":"Palero","full_name":"Palero, Ferran"},{"first_name":"Pere","last_name":"Abello","full_name":"Abello, Pere"},{"full_name":"Macpherson, Enrique","first_name":"Enrique","last_name":"Macpherson"},{"last_name":"Beaumont","first_name":"Mark","full_name":"Beaumont, Mark"},{"full_name":"Pascual, Marta","last_name":"Pascual","first_name":"Marta"}],"abstract":[{"text":"Defining population structure and genetic diversity levels is of the utmost importance for developing efficient conservation strategies. Overfishing has caused mean annual catches of the European spiny lobster (Palinurus elephas) to decrease alarmingly along its distribution area. In this context, there is a need for comprehensive studies aiming to evaluate the genetic health of the exploited populations. The present study is based on a set of ten nuclear markers amplified in 331 individuals from ten different localities covering most of P. elephas distribution area. Samples from Atlantic and Mediterranean basins showed small but significant differences, indicating that P. elephas populations do not behave as a single panmictic unit but form two partially-overlapping groups. Despite intense overfishing, our dataset did not recover a recent bottleneck signal, and instead showed a large and stable historical effective size. This result could be accounted for by specific life-history traits (reproduction and longevity) and the limitations of molecular markers in covering recent timescales for nontemporal samples. The findings of the present study emphasize the need to integrate information on effective population sizes and life-history parameters when evaluating population connectivity levels from genetic data.","lang":"eng"}],"related_material":{"record":[{"relation":"research_data","status":"public","id":"9762"}]},"scopus_import":"1","date_published":"2011-09-14T00:00:00Z","_id":"3395","date_created":"2018-12-11T12:03:06Z","publist_id":"3212","acknowledgement":"This work was supported by a pre-doctoral fellowship awarded by the Autonomous Government of Catalonia to F.P. (2006FIC-00082). Research was funded by projects FBBVA-BIOCON 08-187/09, CGL2006-13423, and CTM2007-66635. The authors are part of the research group 2009SGR-636, 2009SGR-655, and 2009SGR-1364 of the Generalitat de Catalunya. F.P. acknowledges EU-Synthesys grant (GB-TAF-4474).","article_processing_charge":"No","publication":"Biological Journal of the Linnean Society","user_id":"6785fbc1-c503-11eb-8a32-93094b40e1cf","status":"public","department":[{"_id":"NiBa"}],"title":"Effect of oceanographic barriers and overfishing on the population genetic structure of the European spiny lobster Palinurus elephas","publisher":"Wiley-Blackwell","quality_controlled":"1","citation":{"short":"F. Palero, P. Abello, E. Macpherson, M. Beaumont, M. Pascual, Biological Journal of the Linnean Society 104 (2011) 407–418.","ieee":"F. Palero, P. Abello, E. Macpherson, M. Beaumont, and M. Pascual, “Effect of oceanographic barriers and overfishing on the population genetic structure of the European spiny lobster Palinurus elephas,” <i>Biological Journal of the Linnean Society</i>, vol. 104, no. 2. Wiley-Blackwell, pp. 407–418, 2011.","chicago":"Palero, Ferran, Pere Abello, Enrique Macpherson, Mark Beaumont, and Marta Pascual. “Effect of Oceanographic Barriers and Overfishing on the Population Genetic Structure of the European Spiny Lobster Palinurus Elephas.” <i>Biological Journal of the Linnean Society</i>. Wiley-Blackwell, 2011. <a href=\"https://doi.org/10.1111/j.1095-8312.2011.01728.x\">https://doi.org/10.1111/j.1095-8312.2011.01728.x</a>.","apa":"Palero, F., Abello, P., Macpherson, E., Beaumont, M., &#38; Pascual, M. (2011). Effect of oceanographic barriers and overfishing on the population genetic structure of the European spiny lobster Palinurus elephas. <i>Biological Journal of the Linnean Society</i>. Wiley-Blackwell. <a href=\"https://doi.org/10.1111/j.1095-8312.2011.01728.x\">https://doi.org/10.1111/j.1095-8312.2011.01728.x</a>","mla":"Palero, Ferran, et al. “Effect of Oceanographic Barriers and Overfishing on the Population Genetic Structure of the European Spiny Lobster Palinurus Elephas.” <i>Biological Journal of the Linnean Society</i>, vol. 104, no. 2, Wiley-Blackwell, 2011, pp. 407–18, doi:<a href=\"https://doi.org/10.1111/j.1095-8312.2011.01728.x\">10.1111/j.1095-8312.2011.01728.x</a>.","ama":"Palero F, Abello P, Macpherson E, Beaumont M, Pascual M. Effect of oceanographic barriers and overfishing on the population genetic structure of the European spiny lobster Palinurus elephas. <i>Biological Journal of the Linnean Society</i>. 2011;104(2):407-418. doi:<a href=\"https://doi.org/10.1111/j.1095-8312.2011.01728.x\">10.1111/j.1095-8312.2011.01728.x</a>","ista":"Palero F, Abello P, Macpherson E, Beaumont M, Pascual M. 2011. Effect of oceanographic barriers and overfishing on the population genetic structure of the European spiny lobster Palinurus elephas. Biological Journal of the Linnean Society. 104(2), 407–418."},"day":"14","oa_version":"None","volume":104,"page":"407 - 418"},{"acknowledged_ssus":[{"_id":"Bio"},{"_id":"PreCl"}],"type":"journal_article","date_updated":"2021-01-12T07:43:11Z","publication_status":"published","intvolume":"       138","month":"09","language":[{"iso":"eng"}],"doi":"10.1242/dev.071233","year":"2011","ddc":["570"],"date_created":"2018-12-11T12:03:06Z","_id":"3396","date_published":"2011-09-28T00:00:00Z","scopus_import":1,"abstract":[{"text":"Facial branchiomotor neurons (FBMNs) in zebrafish and mouse embryonic hindbrain undergo a characteristic tangential migration from rhombomere (r) 4, where they are born, to r6/7. Cohesion among neuroepithelial cells (NCs) has been suggested to function in FBMN migration by inhibiting FBMNs positioned in the basal neuroepithelium such that they move apically between NCs towards the midline of the neuroepithelium instead of tangentially along the basal side of the neuroepithelium towards r6/7. However, direct experimental evaluation of this hypothesis is still lacking. Here, we have used a combination of biophysical cell adhesion measurements and high-resolution time-lapse microscopy to determine the role of NC cohesion in FBMN migration. We show that reducing NC cohesion by interfering with Cadherin 2 (Cdh2) activity results in FBMNs positioned at the basal side of the neuroepithelium moving apically towards the neural tube midline instead of tangentially towards r6/7. In embryos with strongly reduced NC cohesion, ectopic apical FBMN movement frequently results in fusion of the bilateral FBMN clusters over the apical midline of the neural tube. By contrast, reducing cohesion among FBMNs by interfering with Contactin 2 (Cntn2) expression in these cells has little effect on apical FBMN movement, but reduces the fusion of the bilateral FBMN clusters in embryos with strongly diminished NC cohesion. These data provide direct experimental evidence that NC cohesion functions in tangential FBMN migration by restricting their apical movement.","lang":"eng"}],"author":[{"id":"261CB030-E90D-11E9-B182-F697D44B663C","full_name":"Stockinger, Petra","first_name":"Petra","last_name":"Stockinger"},{"orcid":"0000-0002-0912-4566","last_name":"Heisenberg","first_name":"Carl-Philipp J","full_name":"Heisenberg, Carl-Philipp J","id":"39427864-F248-11E8-B48F-1D18A9856A87"},{"id":"48F1E0D8-F248-11E8-B48F-1D18A9856A87","last_name":"Maître","orcid":"0000-0002-3688-1474","first_name":"Jean-Léon","full_name":"Maître, Jean-Léon"}],"issue":"21","publisher":"Company of Biologists","status":"public","title":"Defective neuroepithelial cell cohesion affects tangential branchiomotor neuron migration in the zebrafish neural tube","department":[{"_id":"CaHe"}],"has_accepted_license":"1","file_date_updated":"2020-07-14T12:46:12Z","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","publication":"Development","publist_id":"3210","file":[{"relation":"main_file","content_type":"application/pdf","file_name":"2011_Development_Stockinger.pdf","file_id":"6930","creator":"dernst","file_size":4672439,"access_level":"open_access","checksum":"ca12b79e01ef36c1ef1aea31cf7e7139","date_created":"2019-10-07T14:19:42Z","date_updated":"2020-07-14T12:46:12Z"}],"volume":138,"oa_version":"Published Version","page":"4673 - 4683","article_type":"original","day":"28","oa":1,"citation":{"apa":"Stockinger, P., Heisenberg, C.-P. J., &#38; Maître, J.-L. (2011). Defective neuroepithelial cell cohesion affects tangential branchiomotor neuron migration in the zebrafish neural tube. <i>Development</i>. Company of Biologists. <a href=\"https://doi.org/10.1242/dev.071233\">https://doi.org/10.1242/dev.071233</a>","ama":"Stockinger P, Heisenberg C-PJ, Maître J-L. Defective neuroepithelial cell cohesion affects tangential branchiomotor neuron migration in the zebrafish neural tube. <i>Development</i>. 2011;138(21):4673-4683. doi:<a href=\"https://doi.org/10.1242/dev.071233\">10.1242/dev.071233</a>","mla":"Stockinger, Petra, et al. “Defective Neuroepithelial Cell Cohesion Affects Tangential Branchiomotor Neuron Migration in the Zebrafish Neural Tube.” <i>Development</i>, vol. 138, no. 21, Company of Biologists, 2011, pp. 4673–83, doi:<a href=\"https://doi.org/10.1242/dev.071233\">10.1242/dev.071233</a>.","ista":"Stockinger P, Heisenberg C-PJ, Maître J-L. 2011. Defective neuroepithelial cell cohesion affects tangential branchiomotor neuron migration in the zebrafish neural tube. Development. 138(21), 4673–4683.","short":"P. Stockinger, C.-P.J. Heisenberg, J.-L. Maître, Development 138 (2011) 4673–4683.","ieee":"P. Stockinger, C.-P. J. Heisenberg, and J.-L. Maître, “Defective neuroepithelial cell cohesion affects tangential branchiomotor neuron migration in the zebrafish neural tube,” <i>Development</i>, vol. 138, no. 21. Company of Biologists, pp. 4673–4683, 2011.","chicago":"Stockinger, Petra, Carl-Philipp J Heisenberg, and Jean-Léon Maître. “Defective Neuroepithelial Cell Cohesion Affects Tangential Branchiomotor Neuron Migration in the Zebrafish Neural Tube.” <i>Development</i>. Company of Biologists, 2011. <a href=\"https://doi.org/10.1242/dev.071233\">https://doi.org/10.1242/dev.071233</a>."},"quality_controlled":"1"},{"oa_version":"Submitted Version","volume":23,"page":"508 - 514","_id":"3397","date_created":"2018-12-11T12:03:06Z","main_file_link":[{"url":"http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3188705/","open_access":"1"}],"date_published":"2011-10-01T00:00:00Z","scopus_import":1,"oa":1,"citation":{"ista":"Maître J-L, Heisenberg C-PJ. 2011. The role of adhesion energy in controlling cell-cell contacts. Current Opinion in Cell Biology. 23(5), 508–514.","apa":"Maître, J.-L., &#38; Heisenberg, C.-P. J. (2011). The role of adhesion energy in controlling cell-cell contacts. <i>Current Opinion in Cell Biology</i>. Elsevier. <a href=\"https://doi.org/10.1016/j.ceb.2011.07.004\">https://doi.org/10.1016/j.ceb.2011.07.004</a>","mla":"Maître, Jean-Léon, and Carl-Philipp J. Heisenberg. “The Role of Adhesion Energy in Controlling Cell-Cell Contacts.” <i>Current Opinion in Cell Biology</i>, vol. 23, no. 5, Elsevier, 2011, pp. 508–14, doi:<a href=\"https://doi.org/10.1016/j.ceb.2011.07.004\">10.1016/j.ceb.2011.07.004</a>.","ama":"Maître J-L, Heisenberg C-PJ. The role of adhesion energy in controlling cell-cell contacts. <i>Current Opinion in Cell Biology</i>. 2011;23(5):508-514. doi:<a href=\"https://doi.org/10.1016/j.ceb.2011.07.004\">10.1016/j.ceb.2011.07.004</a>","ieee":"J.-L. Maître and C.-P. J. Heisenberg, “The role of adhesion energy in controlling cell-cell contacts,” <i>Current Opinion in Cell Biology</i>, vol. 23, no. 5. Elsevier, pp. 508–514, 2011.","chicago":"Maître, Jean-Léon, and Carl-Philipp J Heisenberg. “The Role of Adhesion Energy in Controlling Cell-Cell Contacts.” <i>Current Opinion in Cell Biology</i>. Elsevier, 2011. <a href=\"https://doi.org/10.1016/j.ceb.2011.07.004\">https://doi.org/10.1016/j.ceb.2011.07.004</a>.","short":"J.-L. Maître, C.-P.J. Heisenberg, Current Opinion in Cell Biology 23 (2011) 508–514."},"day":"01","issue":"5","quality_controlled":"1","abstract":[{"lang":"eng","text":"Recent advances in microscopy techniques and biophysical measurements have provided novel insight into the molecular, cellular and biophysical basis of cell adhesion. However, comparably little is known about a core element of cell–cell adhesion—the energy of adhesion at the cell–cell contact. In this review, we discuss approaches to understand the nature and regulation of adhesion energy, and propose strategies to determine adhesion energy between cells in vitro and in vivo."}],"author":[{"full_name":"Maître, Jean-Léon","first_name":"Jean-Léon","orcid":"0000-0002-3688-1474","last_name":"Maître","id":"48F1E0D8-F248-11E8-B48F-1D18A9856A87"},{"id":"39427864-F248-11E8-B48F-1D18A9856A87","first_name":"Carl-Philipp J","orcid":"0000-0002-0912-4566","last_name":"Heisenberg","full_name":"Heisenberg, Carl-Philipp J"}],"type":"journal_article","date_updated":"2021-01-12T07:43:12Z","publisher":"Elsevier","user_id":"4435EBFC-F248-11E8-B48F-1D18A9856A87","publication_status":"published","intvolume":"        23","status":"public","title":"The role of adhesion energy in controlling cell-cell contacts","department":[{"_id":"CaHe"}],"language":[{"iso":"eng"}],"month":"10","publication":"Current Opinion in Cell Biology","doi":"10.1016/j.ceb.2011.07.004","year":"2011","publist_id":"3211"},{"publication":"PLoS One","publist_id":"3059","acknowledgement":"This work was supported by the German Science Foundation (www.dfg.de, He 1623/23).","publisher":"Public Library of Science","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","file_date_updated":"2020-07-14T12:46:12Z","has_accepted_license":"1","title":"Competition and opportunity shape the reproductive tactics of males in the ant Cardiocondyla obscurior","status":"public","department":[{"_id":"SyCr"}],"citation":{"ista":"Cremer S, Schrempf A, Heinze J. 2011. Competition and opportunity shape the reproductive tactics of males in the ant Cardiocondyla obscurior. PLoS One. 6(3), e17323.","mla":"Cremer, Sylvia, et al. “Competition and Opportunity Shape the Reproductive Tactics of Males in the Ant Cardiocondyla Obscurior.” <i>PLoS One</i>, vol. 6, no. 3, e17323, Public Library of Science, 2011, doi:<a href=\"https://doi.org/10.1371/journal.pone.0017323\">10.1371/journal.pone.0017323</a>.","ama":"Cremer S, Schrempf A, Heinze J. Competition and opportunity shape the reproductive tactics of males in the ant Cardiocondyla obscurior. <i>PLoS One</i>. 2011;6(3). doi:<a href=\"https://doi.org/10.1371/journal.pone.0017323\">10.1371/journal.pone.0017323</a>","apa":"Cremer, S., Schrempf, A., &#38; Heinze, J. (2011). Competition and opportunity shape the reproductive tactics of males in the ant Cardiocondyla obscurior. <i>PLoS One</i>. Public Library of Science. <a href=\"https://doi.org/10.1371/journal.pone.0017323\">https://doi.org/10.1371/journal.pone.0017323</a>","ieee":"S. Cremer, A. Schrempf, and J. Heinze, “Competition and opportunity shape the reproductive tactics of males in the ant Cardiocondyla obscurior,” <i>PLoS One</i>, vol. 6, no. 3. Public Library of Science, 2011.","chicago":"Cremer, Sylvia, Alexandra Schrempf, and Jürgen Heinze. “Competition and Opportunity Shape the Reproductive Tactics of Males in the Ant Cardiocondyla Obscurior.” <i>PLoS One</i>. Public Library of Science, 2011. <a href=\"https://doi.org/10.1371/journal.pone.0017323\">https://doi.org/10.1371/journal.pone.0017323</a>.","short":"S. Cremer, A. Schrempf, J. Heinze, PLoS One 6 (2011)."},"oa":1,"day":"29","article_number":"e17323","quality_controlled":"1","oa_version":"Published Version","volume":6,"file":[{"file_id":"5162","creator":"system","relation":"main_file","content_type":"application/pdf","file_name":"IST-2015-377-v1+1_journal.pone.0017323.pdf","file_size":147367,"access_level":"open_access","checksum":"46f8cbde61f06fcacf8fa297cacfa0e5","date_updated":"2020-07-14T12:46:12Z","date_created":"2018-12-12T10:15:40Z"}],"tmp":{"image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","short":"CC BY (4.0)"},"language":[{"iso":"eng"}],"month":"03","ddc":["576"],"year":"2011","doi":"10.1371/journal.pone.0017323","date_updated":"2021-01-12T07:43:12Z","type":"journal_article","intvolume":"         6","publication_status":"published","pubrep_id":"377","issue":"3","author":[{"id":"2F64EC8C-F248-11E8-B48F-1D18A9856A87","full_name":"Cremer, Sylvia","last_name":"Cremer","orcid":"0000-0002-2193-3868","first_name":"Sylvia"},{"full_name":"Schrempf, Alexandra","last_name":"Schrempf","first_name":"Alexandra"},{"last_name":"Heinze","first_name":"Jürgen","full_name":"Heinze, Jürgen"}],"abstract":[{"text":"Context-dependent adjustment of mating tactics can drastically increase the mating success of behaviourally flexible animals. We used the ant Cardiocondyla obscurior as a model system to study adaptive adjustment of male mating tactics. This species shows a male diphenism of wingless fighter males and peaceful winged males. Whereas the wingless males stay and exclusively mate in the maternal colony, the mating behaviour of winged males is plastic. They copulate with female sexuals in their natal nests early in life but later disperse in search for sexuals outside. In this study, we observed the nest-leaving behaviour of winged males under different conditions and found that they adaptively adjust the timing of their dispersal to the availability of mating partners, as well as the presence, and even the type of competitors in their natal nests. In colonies with virgin female queens winged males stayed longest when they were the only male in the nest. They left earlier when mating partners were not available or when other males were present. In the presence of wingless, locally mating fighter males, winged males dispersed earlier than in the presence of docile, winged competitors. This suggests that C. obscurior males are capable of estimating their local breeding chances and adaptively adjust their dispersal behaviour in both an opportunistic and a risk-sensitive way, thus showing hitherto unknown behavioural plasticity in social insect males.","lang":"eng"}],"_id":"3399","date_created":"2018-12-11T12:03:07Z","scopus_import":1,"date_published":"2011-03-29T00:00:00Z"},{"file":[{"date_updated":"2020-07-14T12:46:12Z","date_created":"2018-12-12T10:11:36Z","checksum":"6b68d65aadd97c18d663eb117a0a9d35","access_level":"open_access","file_size":387654,"creator":"system","file_id":"4891","file_name":"IST-2017-832-v1+1_janovjak.pdf","relation":"main_file","content_type":"application/pdf"}],"page":"1 - 6","oa_version":"Submitted Version","volume":2,"quality_controlled":"1","day":"08","citation":{"ista":"Janovjak HL, Sandoz G, Isacoff E. 2011. Modern ionotropic glutamate receptor with a K+ selectivity signature sequence. Nature Communications. 2(232), 1–6.","ama":"Janovjak HL, Sandoz G, Isacoff E. Modern ionotropic glutamate receptor with a K+ selectivity signature sequence. <i>Nature Communications</i>. 2011;2(232):1-6. doi:<a href=\"https://doi.org/10.1038/ncomms1231\">10.1038/ncomms1231</a>","mla":"Janovjak, Harald L., et al. “Modern Ionotropic Glutamate Receptor with a K+ Selectivity Signature Sequence.” <i>Nature Communications</i>, vol. 2, no. 232, Nature Publishing Group, 2011, pp. 1–6, doi:<a href=\"https://doi.org/10.1038/ncomms1231\">10.1038/ncomms1231</a>.","apa":"Janovjak, H. L., Sandoz, G., &#38; Isacoff, E. (2011). Modern ionotropic glutamate receptor with a K+ selectivity signature sequence. <i>Nature Communications</i>. Nature Publishing Group. <a href=\"https://doi.org/10.1038/ncomms1231\">https://doi.org/10.1038/ncomms1231</a>","ieee":"H. L. Janovjak, G. Sandoz, and E. Isacoff, “Modern ionotropic glutamate receptor with a K+ selectivity signature sequence,” <i>Nature Communications</i>, vol. 2, no. 232. Nature Publishing Group, pp. 1–6, 2011.","chicago":"Janovjak, Harald L, Guillaume Sandoz, and Ehud Isacoff. “Modern Ionotropic Glutamate Receptor with a K+ Selectivity Signature Sequence.” <i>Nature Communications</i>. Nature Publishing Group, 2011. <a href=\"https://doi.org/10.1038/ncomms1231\">https://doi.org/10.1038/ncomms1231</a>.","short":"H.L. Janovjak, G. Sandoz, E. Isacoff, Nature Communications 2 (2011) 1–6."},"oa":1,"has_accepted_license":"1","title":"Modern ionotropic glutamate receptor with a K+ selectivity signature sequence","department":[{"_id":"HaJa"}],"status":"public","user_id":"4435EBFC-F248-11E8-B48F-1D18A9856A87","file_date_updated":"2020-07-14T12:46:12Z","publisher":"Nature Publishing Group","publist_id":"2997","publication":"Nature Communications","scopus_import":1,"date_published":"2011-03-08T00:00:00Z","date_created":"2018-12-11T12:03:09Z","_id":"3405","abstract":[{"lang":"eng","text":"Glutamate is the major excitatory neurotransmitter in the mammalian central nervous system and gates non-selective cation channels. The origins of glutamate receptors are not well understood as they differ structurally and functionally from simple bacterial ligand-gated ion channels. Here we report the discovery of an ionotropic glutamate receptor that combines the typical eukaryotic domain architecture with the 'TXVGYG' signature sequence of the selectivity filter found in K+ channels. This receptor exhibits functional properties intermediate between bacterial and eukaryotic glutamate-gated ion channels, suggesting a link in the evolution of ionotropic glutamate receptors."}],"author":[{"id":"33BA6C30-F248-11E8-B48F-1D18A9856A87","full_name":"Janovjak, Harald L","last_name":"Janovjak","orcid":"0000-0002-8023-9315","first_name":"Harald L"},{"full_name":"Sandoz, Guillaume","first_name":"Guillaume","last_name":"Sandoz"},{"full_name":"Isacoff, Ehud","last_name":"Isacoff","first_name":"Ehud"}],"issue":"232","pubrep_id":"832","intvolume":"         2","publication_status":"published","date_updated":"2021-01-12T07:43:15Z","type":"journal_article","year":"2011","doi":"10.1038/ncomms1231","ddc":["570","571"],"month":"03","language":[{"iso":"eng"}]},{"publist_id":"2971","year":"2011","acknowledgement":"This work was supported by the Beckman Institute and Biological Imaging Center at the California Institute of Technology and by the NHGRI Center of Excellence in Genomic Science grant P50HG004071.","doi":"10.1038/ncb2154","language":[{"iso":"eng"}],"month":"01","publication":"Nature Cell Biology","user_id":"4435EBFC-F248-11E8-B48F-1D18A9856A87","status":"public","intvolume":"        13","title":"Oct4 kinetics predict cell lineage patterning in the early mammalian embryo","department":[{"_id":"ToBo"}],"publication_status":"published","date_updated":"2021-01-12T07:43:24Z","type":"journal_article","publisher":"Nature Publishing Group","issue":"2","author":[{"full_name":"Plachta, Nicolas","last_name":"Plachta","first_name":"Nicolas"},{"id":"3E6DB97A-F248-11E8-B48F-1D18A9856A87","last_name":"Bollenbach","orcid":"0000-0003-4398-476X","first_name":"Mark Tobias","full_name":"Bollenbach, Mark Tobias"},{"full_name":"Pease, Shirley","first_name":"Shirley","last_name":"Pease"},{"full_name":"Fraser, Scott","first_name":"Scott","last_name":"Fraser"},{"first_name":"Periklis","last_name":"Pantazis","full_name":"Pantazis, Periklis"}],"abstract":[{"text":"Transcription factors are central to sustaining pluripotency, yet little is known about transcription factor dynamics in defining pluripotency in the early mammalian embryo. Here, we establish a fluorescence decay after photoactivation (FDAP) assay to quantitatively study the kinetic behaviour of Oct4, a key transcription factor controlling pre-implantation development in the mouse embryo. FDAP measurements reveal that each cell in a developing embryo shows one of two distinct Oct4 kinetics, before there are any morphologically distinguishable differences or outward signs of lineage patterning. The differences revealed by FDAP are due to differences in the accessibility of Oct4 to its DNA binding sites in the nucleus. Lineage tracing of the cells in the two distinct sub-populations demonstrates that the Oct4 kinetics predict lineages of the early embryo. Cells with slower Oct4 kinetics are more likely to give rise to the pluripotent cell lineage that contributes to the inner cell mass. Those with faster Oct4 kinetics contribute mostly to the extra-embryonic lineage. Our findings identify Oct4 kinetics, rather than differences in total transcription factor expression levels, as a predictive measure of developmental cell lineage patterning in the early mouse embryo.","lang":"eng"}],"citation":{"short":"N. Plachta, M.T. Bollenbach, S. Pease, S. Fraser, P. Pantazis, Nature Cell Biology 13 (2011) 117–123.","chicago":"Plachta, Nicolas, Mark Tobias Bollenbach, Shirley Pease, Scott Fraser, and Periklis Pantazis. “Oct4 Kinetics Predict Cell Lineage Patterning in the Early Mammalian Embryo.” <i>Nature Cell Biology</i>. Nature Publishing Group, 2011. <a href=\"https://doi.org/10.1038/ncb2154\">https://doi.org/10.1038/ncb2154</a>.","ieee":"N. Plachta, M. T. Bollenbach, S. Pease, S. Fraser, and P. Pantazis, “Oct4 kinetics predict cell lineage patterning in the early mammalian embryo,” <i>Nature Cell Biology</i>, vol. 13, no. 2. Nature Publishing Group, pp. 117–123, 2011.","apa":"Plachta, N., Bollenbach, M. T., Pease, S., Fraser, S., &#38; Pantazis, P. (2011). Oct4 kinetics predict cell lineage patterning in the early mammalian embryo. <i>Nature Cell Biology</i>. Nature Publishing Group. <a href=\"https://doi.org/10.1038/ncb2154\">https://doi.org/10.1038/ncb2154</a>","mla":"Plachta, Nicolas, et al. “Oct4 Kinetics Predict Cell Lineage Patterning in the Early Mammalian Embryo.” <i>Nature Cell Biology</i>, vol. 13, no. 2, Nature Publishing Group, 2011, pp. 117–23, doi:<a href=\"https://doi.org/10.1038/ncb2154\">10.1038/ncb2154</a>.","ama":"Plachta N, Bollenbach MT, Pease S, Fraser S, Pantazis P. Oct4 kinetics predict cell lineage patterning in the early mammalian embryo. <i>Nature Cell Biology</i>. 2011;13(2):117-123. doi:<a href=\"https://doi.org/10.1038/ncb2154\">10.1038/ncb2154</a>","ista":"Plachta N, Bollenbach MT, Pease S, Fraser S, Pantazis P. 2011. Oct4 kinetics predict cell lineage patterning in the early mammalian embryo. Nature Cell Biology. 13(2), 117–123."},"day":"23","scopus_import":1,"date_published":"2011-01-23T00:00:00Z","_id":"3429","oa_version":"None","page":"117 - 123","volume":13,"date_created":"2018-12-11T12:03:17Z"},{"year":"2011","doi":"10.1007/978-1-61779-207-6_11","month":"05","language":[{"iso":"eng"}],"intvolume":"       769","publication_status":"published","date_updated":"2021-01-12T07:43:55Z","type":"journal_article","abstract":[{"lang":"eng","text":"Cell migration on two-dimensional (2D) substrates follows entirely different rules than cell migration in three-dimensional (3D) environments. This is especially relevant for leukocytes that are able to migrate in the absence of adhesion receptors within the confined geometry of artificial 3D extracellular matrix scaffolds and within the interstitial space in vivo. Here, we describe in detail a simple and economical protocol to visualize dendritic cell migration in 3D collagen scaffolds along chemotactic gradients. This method can be adapted to other cell types and may serve as a physiologically relevant paradigm for the directed locomotion of most amoeboid cells."}],"author":[{"id":"41E9FBEA-F248-11E8-B48F-1D18A9856A87","last_name":"Sixt","orcid":"0000-0002-6620-9179","first_name":"Michael K","full_name":"Sixt, Michael K"},{"full_name":"Lämmermann, Tim","first_name":"Tim","last_name":"Lämmermann"}],"date_published":"2011-05-17T00:00:00Z","date_created":"2018-12-11T12:03:41Z","_id":"3505","publist_id":"2882","publication":"Cell Migration","article_processing_charge":"No","status":"public","title":"In vitro analysis of chemotactic leukocyte migration in 3D environments","department":[{"_id":"MiSi"}],"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","publisher":"Springer","quality_controlled":"1","day":"17","citation":{"apa":"Sixt, M. K., &#38; Lämmermann, T. (2011). In vitro analysis of chemotactic leukocyte migration in 3D environments. <i>Cell Migration</i>. Springer. <a href=\"https://doi.org/10.1007/978-1-61779-207-6_11\">https://doi.org/10.1007/978-1-61779-207-6_11</a>","mla":"Sixt, Michael K., and Tim Lämmermann. “In Vitro Analysis of Chemotactic Leukocyte Migration in 3D Environments.” <i>Cell Migration</i>, vol. 769, Springer, 2011, pp. 149–65, doi:<a href=\"https://doi.org/10.1007/978-1-61779-207-6_11\">10.1007/978-1-61779-207-6_11</a>.","ama":"Sixt MK, Lämmermann T. In vitro analysis of chemotactic leukocyte migration in 3D environments. <i>Cell Migration</i>. 2011;769:149-165. doi:<a href=\"https://doi.org/10.1007/978-1-61779-207-6_11\">10.1007/978-1-61779-207-6_11</a>","ista":"Sixt MK, Lämmermann T. 2011. In vitro analysis of chemotactic leukocyte migration in 3D environments. Cell Migration. 769, 149–165.","short":"M.K. Sixt, T. Lämmermann, Cell Migration 769 (2011) 149–165.","ieee":"M. K. Sixt and T. Lämmermann, “In vitro analysis of chemotactic leukocyte migration in 3D environments,” <i>Cell Migration</i>, vol. 769. Springer, pp. 149–165, 2011.","chicago":"Sixt, Michael K, and Tim Lämmermann. “In Vitro Analysis of Chemotactic Leukocyte Migration in 3D Environments.” <i>Cell Migration</i>. Springer, 2011. <a href=\"https://doi.org/10.1007/978-1-61779-207-6_11\">https://doi.org/10.1007/978-1-61779-207-6_11</a>."},"oa":1,"alternative_title":["Methods in Molecular Biology"],"main_file_link":[{"url":"https://pure.mpg.de/pubman/item/item_3219628_1/component/file_3219630/Sixt%20et%20al..pdf","open_access":"1"}],"article_type":"original","page":"149 - 165","oa_version":"Published Version","volume":769},{"intvolume":"       102","status":"public","title":"Patterns of diversification in two species of short-tailed bats (Carollia Gray, 1838): the effects of historical fragmentation of Brazilian rainforests.","department":[{"_id":"FyKo"}],"publication_status":"published","user_id":"4435EBFC-F248-11E8-B48F-1D18A9856A87","publisher":"Wiley-Blackwell","date_updated":"2021-01-12T07:52:05Z","type":"journal_article","publist_id":"2456","year":"2011","doi":"10.1111/j.1095-8312.2010.01601.x","month":"02","publication":"Biological Journal of the Linnean Society","language":[{"iso":"eng"}],"scopus_import":1,"date_published":"2011-02-10T00:00:00Z","date_created":"2018-12-11T12:05:05Z","_id":"3771","page":"527 - 539","volume":102,"oa_version":"None","author":[{"last_name":"Pavan","first_name":"Ana","full_name":"Pavan, Ana"},{"first_name":"Felipe","last_name":"Martins","full_name":"Martins, Felipe"},{"full_name":"Santos, Fabrício","last_name":"Santos","first_name":"Fabrício"},{"first_name":"Albert","last_name":"Ditchfield","full_name":"Ditchfield, Albert"},{"full_name":"Fernandes Redondo, Rodrigo A","first_name":"Rodrigo A","last_name":"Fernandes Redondo","orcid":"0000-0002-5837-2793","id":"409D5C96-F248-11E8-B48F-1D18A9856A87"}],"quality_controlled":"1","abstract":[{"text":"The small-sized frugivorous bat Carollia perspicillata is an understory specialist and occurs in a wide range of lowland habitats, tending to be more common in tropical dry or moist forests of South and Central America. Its sister species, Carollia brevicauda, occurs almost exclusively in the Amazon rainforest. A recent phylogeographic study proposed a hypothesis of origin and subsequent diversification for C. perspicillata along the Atlantic coastal forest of Brazil. Additionally, it also found two allopatric clades for C. brevicauda separated by the Amazon Basin. We used cytochrome b gene sequences and a more extensive sampling to test hypotheses related to the origin and diversification of C. perspicillata plus C. brevicauda clade in South America. The results obtained indicate that there are two sympatric evolutionary lineages within each species. In C. perspicillata, one lineage is limited to the Southern Atlantic Forest, whereas the other is widely distributed. Coalescent analysis points to a simultaneous origin for C. perspicillata and C. brevicauda, although no place for the diversification of each species can be firmly suggested. The phylogeographic pattern shown by C. perspicillata is also congruent with the Pleistocene refugia hypothesis as a likely vicariant phenomenon shaping the present distribution of its intraspecific lineages.","lang":"eng"}],"issue":"3","day":"10","citation":{"short":"A. Pavan, F. Martins, F. Santos, A. Ditchfield, R.A. Fernandes Redondo, Biological Journal of the Linnean Society 102 (2011) 527–539.","chicago":"Pavan, Ana, Felipe Martins, Fabrício Santos, Albert Ditchfield, and Rodrigo A Fernandes Redondo. “Patterns of Diversification in Two Species of Short-Tailed Bats (Carollia Gray, 1838): The Effects of Historical Fragmentation of Brazilian Rainforests.” <i>Biological Journal of the Linnean Society</i>. Wiley-Blackwell, 2011. <a href=\"https://doi.org/10.1111/j.1095-8312.2010.01601.x\">https://doi.org/10.1111/j.1095-8312.2010.01601.x</a>.","ieee":"A. Pavan, F. Martins, F. Santos, A. Ditchfield, and R. A. Fernandes Redondo, “Patterns of diversification in two species of short-tailed bats (Carollia Gray, 1838): the effects of historical fragmentation of Brazilian rainforests.,” <i>Biological Journal of the Linnean Society</i>, vol. 102, no. 3. Wiley-Blackwell, pp. 527–539, 2011.","mla":"Pavan, Ana, et al. “Patterns of Diversification in Two Species of Short-Tailed Bats (Carollia Gray, 1838): The Effects of Historical Fragmentation of Brazilian Rainforests.” <i>Biological Journal of the Linnean Society</i>, vol. 102, no. 3, Wiley-Blackwell, 2011, pp. 527–39, doi:<a href=\"https://doi.org/10.1111/j.1095-8312.2010.01601.x\">10.1111/j.1095-8312.2010.01601.x</a>.","ama":"Pavan A, Martins F, Santos F, Ditchfield A, Fernandes Redondo RA. Patterns of diversification in two species of short-tailed bats (Carollia Gray, 1838): the effects of historical fragmentation of Brazilian rainforests. <i>Biological Journal of the Linnean Society</i>. 2011;102(3):527-539. doi:<a href=\"https://doi.org/10.1111/j.1095-8312.2010.01601.x\">10.1111/j.1095-8312.2010.01601.x</a>","apa":"Pavan, A., Martins, F., Santos, F., Ditchfield, A., &#38; Fernandes Redondo, R. A. (2011). Patterns of diversification in two species of short-tailed bats (Carollia Gray, 1838): the effects of historical fragmentation of Brazilian rainforests. <i>Biological Journal of the Linnean Society</i>. Wiley-Blackwell. <a href=\"https://doi.org/10.1111/j.1095-8312.2010.01601.x\">https://doi.org/10.1111/j.1095-8312.2010.01601.x</a>","ista":"Pavan A, Martins F, Santos F, Ditchfield A, Fernandes Redondo RA. 2011. Patterns of diversification in two species of short-tailed bats (Carollia Gray, 1838): the effects of historical fragmentation of Brazilian rainforests. Biological Journal of the Linnean Society. 102(3), 527–539."}},{"publisher":"Nature Publishing Group","type":"journal_article","date_updated":"2021-01-12T07:52:08Z","publication_status":"published","intvolume":"       106","status":"public","department":[{"_id":"NiBa"}],"title":"Estimating linkage disequilibria","user_id":"3E5EF7F0-F248-11E8-B48F-1D18A9856A87","publication":"Heredity","month":"02","language":[{"iso":"eng"}],"doi":"10.1038/hdy.2010.67","external_id":{"pmid":["20502479"]},"publist_id":"2449","year":"2011","date_created":"2018-12-11T12:05:07Z","oa_version":"Submitted Version","page":"205 - 206","volume":106,"_id":"3778","date_published":"2011-02-01T00:00:00Z","scopus_import":1,"main_file_link":[{"url":"http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3183869/","open_access":"1"}],"pmid":1,"day":"01","oa":1,"citation":{"ista":"Barton NH. 2011. Estimating linkage disequilibria. Heredity. 106(2), 205–206.","mla":"Barton, Nicholas H. “Estimating Linkage Disequilibria.” <i>Heredity</i>, vol. 106, no. 2, Nature Publishing Group, 2011, pp. 205–06, doi:<a href=\"https://doi.org/10.1038/hdy.2010.67\">10.1038/hdy.2010.67</a>.","ama":"Barton NH. Estimating linkage disequilibria. <i>Heredity</i>. 2011;106(2):205-206. doi:<a href=\"https://doi.org/10.1038/hdy.2010.67\">10.1038/hdy.2010.67</a>","apa":"Barton, N. H. (2011). Estimating linkage disequilibria. <i>Heredity</i>. Nature Publishing Group. <a href=\"https://doi.org/10.1038/hdy.2010.67\">https://doi.org/10.1038/hdy.2010.67</a>","ieee":"N. H. Barton, “Estimating linkage disequilibria,” <i>Heredity</i>, vol. 106, no. 2. Nature Publishing Group, pp. 205–206, 2011.","chicago":"Barton, Nicholas H. “Estimating Linkage Disequilibria.” <i>Heredity</i>. Nature Publishing Group, 2011. <a href=\"https://doi.org/10.1038/hdy.2010.67\">https://doi.org/10.1038/hdy.2010.67</a>.","short":"N.H. Barton, Heredity 106 (2011) 205–206."},"author":[{"id":"4880FE40-F248-11E8-B48F-1D18A9856A87","first_name":"Nicholas H","orcid":"0000-0002-8548-5240","last_name":"Barton","full_name":"Barton, Nicholas H"}],"issue":"2"},{"acknowledgement":"Funded by Graduate Aid in Areas of National Need (GAANN) Fellowship.","year":"2011","publist_id":"2446","language":[{"iso":"eng"}],"month":"01","publication":"Acta Sci. Math. (Szeged)","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","publication_status":"published","title":"The difference in length of curves in R^n","department":[{"_id":"HeEd"}],"intvolume":"        77","status":"public","type":"journal_article","date_updated":"2021-01-12T07:52:09Z","publisher":"Szegedi Tudományegyetem","issue":"1-2","quality_controlled":"1","author":[{"last_name":"Fasy","first_name":"Brittany Terese","full_name":"Fasy, Brittany Terese","id":"F65D502E-E68D-11E9-9252-C644099818F6"}],"abstract":[{"lang":"eng","text":"We bound the difference in length of two curves in terms of their total curvatures and the Fréchet distance. The bound is independent of the dimension of the ambient Euclidean space, it improves upon a bound by Cohen-Steiner and Edelsbrunner, and it generalizes a result by Fáry and Chakerian."}],"citation":{"short":"B.T. Fasy, Acta Sci. Math. (Szeged) 77 (2011) 359–367.","ieee":"B. T. Fasy, “The difference in length of curves in R^n,” <i>Acta Sci. Math. (Szeged)</i>, vol. 77, no. 1–2. Szegedi Tudományegyetem, pp. 359–367, 2011.","chicago":"Fasy, Brittany Terese. “The Difference in Length of Curves in R^n.” <i>Acta Sci. Math. (Szeged)</i>. Szegedi Tudományegyetem, 2011.","apa":"Fasy, B. T. (2011). The difference in length of curves in R^n. <i>Acta Sci. Math. (Szeged)</i>. Szegedi Tudományegyetem.","ama":"Fasy BT. The difference in length of curves in R^n. <i>Acta Sci Math (Szeged)</i>. 2011;77(1-2):359-367.","mla":"Fasy, Brittany Terese. “The Difference in Length of Curves in R^n.” <i>Acta Sci. Math. (Szeged)</i>, vol. 77, no. 1–2, Szegedi Tudományegyetem, 2011, pp. 359–67.","ista":"Fasy BT. 2011. The difference in length of curves in R^n. Acta Sci. Math. (Szeged). 77(1–2), 359–367."},"day":"01","date_published":"2011-01-01T00:00:00Z","page":"359 - 367","volume":77,"oa_version":"None","_id":"3781","date_created":"2018-12-11T12:05:08Z"},{"citation":{"ista":"Palero F, Guerao G, Clark P, Abello P. 2011. Scyllarus arctus (Crustacea: Decapoda: Scyllaridae) final stage phyllosoma identified by DNA analysis, with morphological description. Journal of the Marine Biological Association of the United Kingdom. 91(2), 485–492.","apa":"Palero, F., Guerao, G., Clark, P., &#38; Abello, P. (2011). Scyllarus arctus (Crustacea: Decapoda: Scyllaridae) final stage phyllosoma identified by DNA analysis, with morphological description. <i>Journal of the Marine Biological Association of the United Kingdom</i>. Cambridge University Press. <a href=\"https://doi.org/10.1017/S0025315410000287\">https://doi.org/10.1017/S0025315410000287</a>","ama":"Palero F, Guerao G, Clark P, Abello P. Scyllarus arctus (Crustacea: Decapoda: Scyllaridae) final stage phyllosoma identified by DNA analysis, with morphological description. <i>Journal of the Marine Biological Association of the United Kingdom</i>. 2011;91(2):485-492. doi:<a href=\"https://doi.org/10.1017/S0025315410000287\">10.1017/S0025315410000287</a>","mla":"Palero, Ferran, et al. “Scyllarus Arctus (Crustacea: Decapoda: Scyllaridae) Final Stage Phyllosoma Identified by DNA Analysis, with Morphological Description.” <i>Journal of the Marine Biological Association of the United Kingdom</i>, vol. 91, no. 2, Cambridge University Press, 2011, pp. 485–92, doi:<a href=\"https://doi.org/10.1017/S0025315410000287\">10.1017/S0025315410000287</a>.","chicago":"Palero, Ferran, Guillermo Guerao, Paul Clark, and Pere Abello. “Scyllarus Arctus (Crustacea: Decapoda: Scyllaridae) Final Stage Phyllosoma Identified by DNA Analysis, with Morphological Description.” <i>Journal of the Marine Biological Association of the United Kingdom</i>. Cambridge University Press, 2011. <a href=\"https://doi.org/10.1017/S0025315410000287\">https://doi.org/10.1017/S0025315410000287</a>.","ieee":"F. Palero, G. Guerao, P. Clark, and P. Abello, “Scyllarus arctus (Crustacea: Decapoda: Scyllaridae) final stage phyllosoma identified by DNA analysis, with morphological description,” <i>Journal of the Marine Biological Association of the United Kingdom</i>, vol. 91, no. 2. Cambridge University Press, pp. 485–492, 2011.","short":"F. Palero, G. Guerao, P. Clark, P. Abello, Journal of the Marine Biological Association of the United Kingdom 91 (2011) 485–492."},"oa":1,"day":"01","quality_controlled":"1","article_type":"original","page":"485 - 492","volume":91,"oa_version":"Published Version","main_file_link":[{"url":"https://digital.csic.es/bitstream/10261/32783/3/Palero_et_al_2011.pdf","open_access":"1"}],"article_processing_charge":"No","publication":"Journal of the Marine Biological Association of the United Kingdom","publist_id":"2443","publisher":"Cambridge University Press","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","status":"public","title":"Scyllarus arctus (Crustacea: Decapoda: Scyllaridae) final stage phyllosoma identified by DNA analysis, with morphological description","department":[{"_id":"NiBa"}],"issue":"2","abstract":[{"text":"Advanced stages of Scyllarus phyllosoma larvae were collected by demersal trawling during fishery research surveys in the western Mediterranean Sea in 2003–2005. Nucleotide sequence analysis of the mitochondrial 16S rDNA gene allowed the final-stage phyllosoma of Scyllarus arctus to be identified among these larvae. Its morphology is described and illustrated. This constitutes the second complete description of a Scyllaridae phyllosoma with its specific identity being validated by molecular techniques (the first was S. pygmaeus). These results also solved a long lasting taxonomic anomaly of several species assigned to the ancient genus Phyllosoma Leach, 1814. Detailed examination indicated that the final-stage phyllosoma of S. arctus shows closer affinities with the American scyllarid Scyllarus depressus or with the Australian Scyllarus sp. b (sensu Phillips et al., 1981) than to its sympatric species S. pygmaeus.","lang":"eng"}],"author":[{"full_name":"Palero, Ferran","first_name":"Ferran","last_name":"Palero","orcid":"0000-0002-0343-8329","id":"3F0E2A22-F248-11E8-B48F-1D18A9856A87"},{"first_name":"Guillermo","last_name":"Guerao","full_name":"Guerao, Guillermo"},{"full_name":"Clark, Paul","first_name":"Paul","last_name":"Clark"},{"first_name":"Pere","last_name":"Abello","full_name":"Abello, Pere"}],"_id":"3784","date_created":"2018-12-11T12:05:09Z","scopus_import":1,"date_published":"2011-03-01T00:00:00Z","language":[{"iso":"eng"}],"month":"03","year":"2011","doi":"10.1017/S0025315410000287","date_updated":"2021-01-12T07:52:10Z","type":"journal_article","intvolume":"        91","publication_status":"published"},{"type":"book_chapter","date_updated":"2021-01-12T07:52:13Z","publisher":"Elsevier","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","publication_status":"published","title":"Cell sorting in development","status":"public","department":[{"_id":"CaHe"}],"intvolume":"        95","language":[{"iso":"eng"}],"article_processing_charge":"No","publication":"Forces and Tension in Development","month":"01","doi":"10.1016/B978-0-12-385065-2.00006-2","publist_id":"2436","year":"2011","oa_version":"None","volume":95,"page":"189 - 213","_id":"3791","editor":[{"first_name":"Michel","last_name":"Labouesse","full_name":"Labouesse, Michel"}],"date_created":"2018-12-11T12:05:11Z","alternative_title":["Current Topics in Developmental Biology"],"date_published":"2011-01-01T00:00:00Z","scopus_import":"1","citation":{"ista":"Krens G, Heisenberg C-PJ. 2011.Cell sorting in development. In: Forces and Tension in Development. Current Topics in Developmental Biology, vol. 95, 189–213.","apa":"Krens, G., &#38; Heisenberg, C.-P. J. (2011). Cell sorting in development. In M. Labouesse (Ed.), <i>Forces and Tension in Development</i> (Vol. 95, pp. 189–213). Elsevier. <a href=\"https://doi.org/10.1016/B978-0-12-385065-2.00006-2\">https://doi.org/10.1016/B978-0-12-385065-2.00006-2</a>","mla":"Krens, Gabriel, and Carl-Philipp J. Heisenberg. “Cell Sorting in Development.” <i>Forces and Tension in Development</i>, edited by Michel Labouesse, vol. 95, Elsevier, 2011, pp. 189–213, doi:<a href=\"https://doi.org/10.1016/B978-0-12-385065-2.00006-2\">10.1016/B978-0-12-385065-2.00006-2</a>.","ama":"Krens G, Heisenberg C-PJ. Cell sorting in development. In: Labouesse M, ed. <i>Forces and Tension in Development</i>. Vol 95. Elsevier; 2011:189-213. doi:<a href=\"https://doi.org/10.1016/B978-0-12-385065-2.00006-2\">10.1016/B978-0-12-385065-2.00006-2</a>","chicago":"Krens, Gabriel, and Carl-Philipp J Heisenberg. “Cell Sorting in Development.” In <i>Forces and Tension in Development</i>, edited by Michel Labouesse, 95:189–213. Elsevier, 2011. <a href=\"https://doi.org/10.1016/B978-0-12-385065-2.00006-2\">https://doi.org/10.1016/B978-0-12-385065-2.00006-2</a>.","ieee":"G. Krens and C.-P. J. Heisenberg, “Cell sorting in development,” in <i>Forces and Tension in Development</i>, vol. 95, M. Labouesse, Ed. Elsevier, 2011, pp. 189–213.","short":"G. Krens, C.-P.J. Heisenberg, in:, M. Labouesse (Ed.), Forces and Tension in Development, Elsevier, 2011, pp. 189–213."},"day":"01","abstract":[{"text":"During the development of multicellular organisms, cell fate specification is followed by the sorting of different cell types into distinct domains from where the different tissues and organs are formed. Cell sorting involves both the segregation of a mixed population of cells with different fates and properties into distinct domains, and the active maintenance of their segregated state. Because of its biological importance and apparent resemblance to fluid segregation in physics, cell sorting was extensively studied by both biologists and physicists over the last decades. Different theories were developed that try to explain cell sorting on the basis of the physical properties of the constituent cells. However, only recently the molecular and cellular mechanisms that control the physical properties driving cell sorting, have begun to be unraveled. In this review, we will provide an overview of different cell-sorting processes in development and discuss how these processes can be explained by the different sorting theories, and how these theories in turn can be connected to the molecular and cellular mechanisms driving these processes.","lang":"eng"}],"quality_controlled":"1","author":[{"id":"2B819732-F248-11E8-B48F-1D18A9856A87","last_name":"Krens","orcid":"0000-0003-4761-5996","first_name":"Gabriel","full_name":"Krens, Gabriel"},{"id":"39427864-F248-11E8-B48F-1D18A9856A87","full_name":"Heisenberg, Carl-Philipp J","first_name":"Carl-Philipp J","last_name":"Heisenberg","orcid":"0000-0002-0912-4566"}]},{"user_id":"4435EBFC-F248-11E8-B48F-1D18A9856A87","file_date_updated":"2020-07-14T12:46:16Z","title":"Covering and packing with spheres by diagonal distortion in R^n","status":"public","department":[{"_id":"HeEd"}],"has_accepted_license":"1","publisher":"Springer","publist_id":"2427","publication":"Rainbow of Computer Science","series_title":"Dedicated to Hermann Maurer on the Occasion of His 70th Birthday","alternative_title":["LNCS"],"volume":6570,"page":"20 - 35","oa_version":"Submitted Version","file":[{"relation":"main_file","content_type":"application/pdf","file_name":"IST-2016-539-v1+1_2011-B-01-CoveringPacking.pdf","file_id":"4640","creator":"system","file_size":436875,"access_level":"open_access","checksum":"aaf22b4d7bd4277ffe8db532119cf474","date_created":"2018-12-12T10:07:42Z","date_updated":"2020-07-14T12:46:16Z"}],"quality_controlled":"1","citation":{"ista":"Edelsbrunner H, Kerber M. 2011.Covering and packing with spheres by diagonal distortion in R^n. In: Rainbow of Computer Science. LNCS, vol. 6570, 20–35.","mla":"Edelsbrunner, Herbert, and Michael Kerber. “Covering and Packing with Spheres by Diagonal Distortion in R^n.” <i>Rainbow of Computer Science</i>, edited by Cristian Calude et al., vol. 6570, Springer, 2011, pp. 20–35, doi:<a href=\"https://doi.org/10.1007/978-3-642-19391-0_2\">10.1007/978-3-642-19391-0_2</a>.","ama":"Edelsbrunner H, Kerber M. Covering and packing with spheres by diagonal distortion in R^n. In: Calude C, Rozenberg G, Salomaa A, eds. <i>Rainbow of Computer Science</i>. Vol 6570. Dedicated to Hermann Maurer on the Occasion of His 70th Birthday. Springer; 2011:20-35. doi:<a href=\"https://doi.org/10.1007/978-3-642-19391-0_2\">10.1007/978-3-642-19391-0_2</a>","apa":"Edelsbrunner, H., &#38; Kerber, M. (2011). Covering and packing with spheres by diagonal distortion in R^n. In C. Calude, G. Rozenberg, &#38; A. Salomaa (Eds.), <i>Rainbow of Computer Science</i> (Vol. 6570, pp. 20–35). Springer. <a href=\"https://doi.org/10.1007/978-3-642-19391-0_2\">https://doi.org/10.1007/978-3-642-19391-0_2</a>","chicago":"Edelsbrunner, Herbert, and Michael Kerber. “Covering and Packing with Spheres by Diagonal Distortion in R^n.” In <i>Rainbow of Computer Science</i>, edited by Cristian Calude, Grzegorz Rozenberg, and Arto Salomaa, 6570:20–35. Dedicated to Hermann Maurer on the Occasion of His 70th Birthday. Springer, 2011. <a href=\"https://doi.org/10.1007/978-3-642-19391-0_2\">https://doi.org/10.1007/978-3-642-19391-0_2</a>.","ieee":"H. Edelsbrunner and M. Kerber, “Covering and packing with spheres by diagonal distortion in R^n,” in <i>Rainbow of Computer Science</i>, vol. 6570, C. Calude, G. Rozenberg, and A. Salomaa, Eds. Springer, 2011, pp. 20–35.","short":"H. Edelsbrunner, M. Kerber, in:, C. Calude, G. Rozenberg, A. Salomaa (Eds.), Rainbow of Computer Science, Springer, 2011, pp. 20–35."},"oa":1,"day":"03","intvolume":"      6570","publication_status":"published","date_updated":"2021-01-12T07:52:15Z","type":"book_chapter","ddc":["000"],"year":"2011","doi":"10.1007/978-3-642-19391-0_2","language":[{"iso":"eng"}],"month":"05","date_published":"2011-05-03T00:00:00Z","_id":"3796","editor":[{"full_name":"Calude, Cristian","last_name":"Calude","first_name":"Cristian"},{"full_name":"Rozenberg, Grzegorz","last_name":"Rozenberg","first_name":"Grzegorz"},{"full_name":"Salomaa, Arto","first_name":"Arto","last_name":"Salomaa"}],"date_created":"2018-12-11T12:05:13Z","author":[{"full_name":"Edelsbrunner, Herbert","last_name":"Edelsbrunner","orcid":"0000-0002-9823-6833","first_name":"Herbert","id":"3FB178DA-F248-11E8-B48F-1D18A9856A87"},{"full_name":"Kerber, Michael","first_name":"Michael","orcid":"0000-0002-8030-9299","last_name":"Kerber","id":"36E4574A-F248-11E8-B48F-1D18A9856A87"}],"abstract":[{"lang":"eng","text":"We address the problem of covering ℝ n with congruent balls, while minimizing the number of balls that contain an average point. Considering the 1-parameter family of lattices defined by stretching or compressing the integer grid in diagonal direction, we give a closed formula for the covering density that depends on the distortion parameter. We observe that our family contains the thinnest lattice coverings in dimensions 2 to 5. We also consider the problem of packing congruent balls in ℝ n , for which we give a closed formula for the packing density as well. Again we observe that our family contains optimal configurations, this time densest packings in dimensions 2 and 3."}],"pubrep_id":"539"},{"date_created":"2018-12-11T12:06:09Z","oa_version":"None","page":"1 - 13","volume":16,"_id":"3965","date_published":"2011-05-01T00:00:00Z","scopus_import":1,"day":"01","citation":{"chicago":"Wang, Bei, Herbert Edelsbrunner, and Dmitriy Morozov. “Computing Elevation Maxima by Searching the Gauss Sphere.” <i>Journal of Experimental Algorithmics</i>. ACM, 2011. <a href=\"https://doi.org/10.1145/1963190.1970375\">https://doi.org/10.1145/1963190.1970375</a>.","ieee":"B. Wang, H. Edelsbrunner, and D. Morozov, “Computing elevation maxima by searching the Gauss sphere,” <i>Journal of Experimental Algorithmics</i>, vol. 16, no. 2.2. ACM, pp. 1–13, 2011.","short":"B. Wang, H. Edelsbrunner, D. Morozov, Journal of Experimental Algorithmics 16 (2011) 1–13.","ista":"Wang B, Edelsbrunner H, Morozov D. 2011. Computing elevation maxima by searching the Gauss sphere. Journal of Experimental Algorithmics. 16(2.2), 1–13.","apa":"Wang, B., Edelsbrunner, H., &#38; Morozov, D. (2011). Computing elevation maxima by searching the Gauss sphere. <i>Journal of Experimental Algorithmics</i>. ACM. <a href=\"https://doi.org/10.1145/1963190.1970375\">https://doi.org/10.1145/1963190.1970375</a>","ama":"Wang B, Edelsbrunner H, Morozov D. Computing elevation maxima by searching the Gauss sphere. <i>Journal of Experimental Algorithmics</i>. 2011;16(2.2):1-13. doi:<a href=\"https://doi.org/10.1145/1963190.1970375\">10.1145/1963190.1970375</a>","mla":"Wang, Bei, et al. “Computing Elevation Maxima by Searching the Gauss Sphere.” <i>Journal of Experimental Algorithmics</i>, vol. 16, no. 2.2, ACM, 2011, pp. 1–13, doi:<a href=\"https://doi.org/10.1145/1963190.1970375\">10.1145/1963190.1970375</a>."},"abstract":[{"lang":"eng","text":"The elevation function on a smoothly embedded 2-manifold in R-3 reflects the multiscale topography of cavities and protrusions as local maxima. The function has been useful in identifying coarse docking configurations for protein pairs. Transporting the concept from the smooth to the piecewise linear category, this paper describes an algorithm for finding all local maxima. While its worst-case running time is the same as of the algorithm used in prior work, its performance in practice is orders of magnitudes superior. We cast light on this improvement by relating the running time to the total absolute Gaussian curvature of the 2-manifold."}],"author":[{"first_name":"Bei","last_name":"Wang","full_name":"Wang, Bei"},{"last_name":"Edelsbrunner","orcid":"0000-0002-9823-6833","first_name":"Herbert","full_name":"Edelsbrunner, Herbert","id":"3FB178DA-F248-11E8-B48F-1D18A9856A87"},{"full_name":"Morozov, Dmitriy","first_name":"Dmitriy","last_name":"Morozov"}],"quality_controlled":"1","issue":"2.2","publisher":"ACM","type":"journal_article","date_updated":"2021-01-12T07:53:31Z","publication_status":"published","department":[{"_id":"HeEd"}],"title":"Computing elevation maxima by searching the Gauss sphere","status":"public","intvolume":"        16","user_id":"4435EBFC-F248-11E8-B48F-1D18A9856A87","month":"05","publication":"Journal of Experimental Algorithmics","language":[{"iso":"eng"}],"doi":"10.1145/1963190.1970375","publist_id":"2161","year":"2011"},{"type":"journal_article","date_updated":"2021-01-12T07:42:31Z","publication_status":"published","intvolume":"       186","month":"12","language":[{"iso":"eng"}],"doi":"10.1534/genetics.110.123240","year":"2010","date_created":"2018-12-11T12:02:33Z","_id":"3303","date_published":"2010-12-01T00:00:00Z","scopus_import":1,"author":[{"id":"2D0CE020-F248-11E8-B48F-1D18A9856A87","full_name":"Weissman, Daniel","first_name":"Daniel","last_name":"Weissman"},{"last_name":"Feldman","first_name":"Marcus","full_name":"Feldman, Marcus"},{"full_name":"Fisher, Daniel","last_name":"Fisher","first_name":"Daniel"}],"ec_funded":1,"abstract":[{"lang":"eng","text":"Biological traits result in part from interactions between different genetic loci. This can lead to sign epistasis, in which a beneficial adaptation involves a combination of individually deleterious or neutral mutations; in this case, a population must cross a “fitness valley” to adapt. Recombination can assist this process by combining mutations from different individuals or retard it by breaking up the adaptive combination. Here, we analyze the simplest fitness valley, in which an adaptation requires one mutation at each of two loci to provide a fitness benefit. We present a theoretical analysis of the effect of recombination on the valley-crossing process across the full spectrum of possible parameter regimes. We find that low recombination rates can speed up valley crossing relative to the asexual case, while higher recombination rates slow down valley crossing, with the transition between the two regimes occurring when the recombination rate between the loci is approximately equal to the selective advantage provided by the adaptation. In large populations, if the recombination rate is high and selection against single mutants is substantial, the time to cross the valley grows exponentially with population size, effectively meaning that the population cannot acquire the adaptation. Recombination at the optimal (low) rate can reduce the valley-crossing time by up to several orders of magnitude relative to that in an asexual population. "}],"issue":"4","publisher":"Genetics Society of America","department":[{"_id":"NiBa"}],"title":"The rate of fitness-valley crossing in sexual populations","status":"public","user_id":"3E5EF7F0-F248-11E8-B48F-1D18A9856A87","publication":"Genetics","acknowledgement":"This work was supported in part by a Robert N. Noyce Stanford Graduate Fellowship and European Research Council grant 250152 (to D.B.W.) and by National Institutes of Health grant GM 28016 (to M.W.F.).\r\nWe thank Michael Desai for many ideas and discussions and are grateful to Joanna Masel and an anonymous reviewer for their helpful suggestions. ","publist_id":"3337","project":[{"_id":"25B07788-B435-11E9-9278-68D0E5697425","grant_number":"250152","call_identifier":"FP7","name":"Limits to selection in biology and in evolutionary computation"}],"oa_version":"Submitted Version","volume":186,"page":"1389 - 1410","main_file_link":[{"url":"http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2998319/","open_access":"1"}],"day":"01","oa":1,"citation":{"chicago":"Weissman, Daniel, Marcus Feldman, and Daniel Fisher. “The Rate of Fitness-Valley Crossing in Sexual Populations.” <i>Genetics</i>. Genetics Society of America, 2010. <a href=\"https://doi.org/10.1534/genetics.110.123240\">https://doi.org/10.1534/genetics.110.123240</a>.","ieee":"D. Weissman, M. Feldman, and D. Fisher, “The rate of fitness-valley crossing in sexual populations,” <i>Genetics</i>, vol. 186, no. 4. Genetics Society of America, pp. 1389–1410, 2010.","short":"D. Weissman, M. Feldman, D. Fisher, Genetics 186 (2010) 1389–1410.","ista":"Weissman D, Feldman M, Fisher D. 2010. The rate of fitness-valley crossing in sexual populations. Genetics. 186(4), 1389–1410.","ama":"Weissman D, Feldman M, Fisher D. The rate of fitness-valley crossing in sexual populations. <i>Genetics</i>. 2010;186(4):1389-1410. doi:<a href=\"https://doi.org/10.1534/genetics.110.123240\">10.1534/genetics.110.123240</a>","mla":"Weissman, Daniel, et al. “The Rate of Fitness-Valley Crossing in Sexual Populations.” <i>Genetics</i>, vol. 186, no. 4, Genetics Society of America, 2010, pp. 1389–410, doi:<a href=\"https://doi.org/10.1534/genetics.110.123240\">10.1534/genetics.110.123240</a>.","apa":"Weissman, D., Feldman, M., &#38; Fisher, D. (2010). The rate of fitness-valley crossing in sexual populations. <i>Genetics</i>. Genetics Society of America. <a href=\"https://doi.org/10.1534/genetics.110.123240\">https://doi.org/10.1534/genetics.110.123240</a>"},"quality_controlled":"1"},{"author":[{"last_name":"Blanc","first_name":"Régis","full_name":"Blanc, Régis"},{"first_name":"Thomas A","last_name":"Henzinger","orcid":"0000-0002-2985-7724","full_name":"Henzinger, Thomas A","id":"40876CD8-F248-11E8-B48F-1D18A9856A87"},{"full_name":"Hottelier, Thibaud","first_name":"Thibaud","last_name":"Hottelier"},{"full_name":"Kovács, Laura","first_name":"Laura","last_name":"Kovács"}],"abstract":[{"text":"We present ABC, a software tool for automatically computing symbolic upper bounds on the number of iterations of nested program loops. The system combines static analysis of programs with symbolic summation techniques to derive loop invariant relations between program variables. Iteration bounds are obtained from the inferred invariants, by replacing variables with bounds on their greatest values. We have successfully applied ABC to a large number of examples. The derived symbolic bounds express non-trivial polynomial relations over loop variables. We also report on results to automatically infer symbolic expressions over harmonic numbers as upper bounds on loop iteration counts.","lang":"eng"}],"scopus_import":"1","date_published":"2010-05-01T00:00:00Z","date_created":"2022-03-21T08:14:35Z","_id":"10908","conference":{"start_date":"2010-04-25","location":"Dakar, Senegal","name":"LPAR: Conference on Logic for Programming, Artificial Intelligence and Reasoning","end_date":"2010-05-01"},"editor":[{"full_name":"Clarke, Edmund M","first_name":"Edmund M","last_name":"Clarke"},{"full_name":"Voronkov, Andrei","last_name":"Voronkov","first_name":"Andrei"}],"year":"2010","doi":"10.1007/978-3-642-17511-4_7","month":"05","language":[{"iso":"eng"}],"intvolume":"      6355","publication_status":"published","place":"Berlin, Heidelberg","date_updated":"2022-06-13T07:44:21Z","type":"conference","quality_controlled":"1","publication_identifier":{"issn":["0302-9743"],"eissn":["1611-3349"],"isbn":["9783642175107"],"eisbn":["9783642175114"]},"day":"01","citation":{"ama":"Blanc R, Henzinger TA, Hottelier T, Kovács L. ABC: Algebraic Bound Computation for loops. In: Clarke EM, Voronkov A, eds. <i>Logic for Programming, Artificial Intelligence, and Reasoning</i>. Vol 6355. LNCS. Berlin, Heidelberg: Springer Nature; 2010:103-118. doi:<a href=\"https://doi.org/10.1007/978-3-642-17511-4_7\">10.1007/978-3-642-17511-4_7</a>","mla":"Blanc, Régis, et al. “ABC: Algebraic Bound Computation for Loops.” <i>Logic for Programming, Artificial Intelligence, and Reasoning</i>, edited by Edmund M Clarke and Andrei Voronkov, vol. 6355, Springer Nature, 2010, pp. 103–18, doi:<a href=\"https://doi.org/10.1007/978-3-642-17511-4_7\">10.1007/978-3-642-17511-4_7</a>.","apa":"Blanc, R., Henzinger, T. A., Hottelier, T., &#38; Kovács, L. (2010). ABC: Algebraic Bound Computation for loops. In E. M. Clarke &#38; A. Voronkov (Eds.), <i>Logic for Programming, Artificial Intelligence, and Reasoning</i> (Vol. 6355, pp. 103–118). Berlin, Heidelberg: Springer Nature. <a href=\"https://doi.org/10.1007/978-3-642-17511-4_7\">https://doi.org/10.1007/978-3-642-17511-4_7</a>","ista":"Blanc R, Henzinger TA, Hottelier T, Kovács L. 2010. ABC: Algebraic Bound Computation for loops. Logic for Programming, Artificial Intelligence, and Reasoning. LPAR: Conference on Logic for Programming, Artificial Intelligence and ReasoningLNCS vol. 6355, 103–118.","short":"R. Blanc, T.A. Henzinger, T. Hottelier, L. Kovács, in:, E.M. Clarke, A. Voronkov (Eds.), Logic for Programming, Artificial Intelligence, and Reasoning, Springer Nature, Berlin, Heidelberg, 2010, pp. 103–118.","ieee":"R. Blanc, T. A. Henzinger, T. Hottelier, and L. Kovács, “ABC: Algebraic Bound Computation for loops,” in <i>Logic for Programming, Artificial Intelligence, and Reasoning</i>, Dakar, Senegal, 2010, vol. 6355, pp. 103–118.","chicago":"Blanc, Régis, Thomas A Henzinger, Thibaud Hottelier, and Laura Kovács. “ABC: Algebraic Bound Computation for Loops.” In <i>Logic for Programming, Artificial Intelligence, and Reasoning</i>, edited by Edmund M Clarke and Andrei Voronkov, 6355:103–18. LNCS. Berlin, Heidelberg: Springer Nature, 2010. <a href=\"https://doi.org/10.1007/978-3-642-17511-4_7\">https://doi.org/10.1007/978-3-642-17511-4_7</a>."},"oa":1,"series_title":"LNCS","main_file_link":[{"open_access":"1","url":"https://infoscience.epfl.ch/record/186096"}],"oa_version":"Submitted Version","page":"103-118","volume":6355,"acknowledgement":"This work was supported in part by the Swiss NSF. The fourth author is supported by an FWF Hertha Firnberg Research grant (T425-N23).","publication":"Logic for Programming, Artificial Intelligence, and Reasoning","article_processing_charge":"No","status":"public","department":[{"_id":"ToHe"}],"title":"ABC: Algebraic Bound Computation for loops","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","publisher":"Springer Nature"}]