[{"month":"03","author":[{"full_name":"Du, Wei","last_name":"Du","first_name":"Wei"},{"id":"4677C796-F248-11E8-B48F-1D18A9856A87","first_name":"Andreas","last_name":"Angermayr","orcid":"0000-0001-8619-2223","full_name":"Angermayr, Andreas"},{"last_name":"Jongbloets","first_name":"Joeri","full_name":"Jongbloets, Joeri"},{"full_name":"Molenaar, Douwe","first_name":"Douwe","last_name":"Molenaar"},{"last_name":"Bachmann","first_name":"Herwig","full_name":"Bachmann, Herwig"},{"full_name":"Hellingwerf, Klaas","first_name":"Klaas","last_name":"Hellingwerf"},{"full_name":"Branco Dos Santos, Filipe","last_name":"Branco Dos Santos","first_name":"Filipe"}],"citation":{"chicago":"Du, Wei, Andreas Angermayr, Joeri Jongbloets, Douwe Molenaar, Herwig Bachmann, Klaas Hellingwerf, and Filipe Branco Dos Santos. “Nonhierarchical Flux Regulation Exposes the Fitness Burden Associated with Lactate Production in Synechocystis Sp. PCC6803.” <i>ACS Synthetic Biology</i>. American Chemical Society, 2017. <a href=\"https://doi.org/10.1021/acssynbio.6b00235\">https://doi.org/10.1021/acssynbio.6b00235</a>.","ieee":"W. Du <i>et al.</i>, “Nonhierarchical flux regulation exposes the fitness burden associated with lactate production in Synechocystis sp. PCC6803,” <i>ACS Synthetic Biology</i>, vol. 6, no. 3. American Chemical Society, pp. 395–401, 2017.","mla":"Du, Wei, et al. “Nonhierarchical Flux Regulation Exposes the Fitness Burden Associated with Lactate Production in Synechocystis Sp. PCC6803.” <i>ACS Synthetic Biology</i>, vol. 6, no. 3, American Chemical Society, 2017, pp. 395–401, doi:<a href=\"https://doi.org/10.1021/acssynbio.6b00235\">10.1021/acssynbio.6b00235</a>.","short":"W. Du, A. Angermayr, J. Jongbloets, D. Molenaar, H. Bachmann, K. Hellingwerf, F. Branco Dos Santos, ACS Synthetic Biology 6 (2017) 395–401.","ama":"Du W, Angermayr A, Jongbloets J, et al. Nonhierarchical flux regulation exposes the fitness burden associated with lactate production in Synechocystis sp. PCC6803. <i>ACS Synthetic Biology</i>. 2017;6(3):395-401. doi:<a href=\"https://doi.org/10.1021/acssynbio.6b00235\">10.1021/acssynbio.6b00235</a>","ista":"Du W, Angermayr A, Jongbloets J, Molenaar D, Bachmann H, Hellingwerf K, Branco Dos Santos F. 2017. Nonhierarchical flux regulation exposes the fitness burden associated with lactate production in Synechocystis sp. PCC6803. ACS Synthetic Biology. 6(3), 395–401.","apa":"Du, W., Angermayr, A., Jongbloets, J., Molenaar, D., Bachmann, H., Hellingwerf, K., &#38; Branco Dos Santos, F. (2017). Nonhierarchical flux regulation exposes the fitness burden associated with lactate production in Synechocystis sp. PCC6803. <i>ACS Synthetic Biology</i>. American Chemical Society. <a href=\"https://doi.org/10.1021/acssynbio.6b00235\">https://doi.org/10.1021/acssynbio.6b00235</a>"},"article_type":"letter_note","issue":"3","page":"395 - 401","language":[{"iso":"eng"}],"_id":"520","external_id":{"pmid":["27936615"]},"title":"Nonhierarchical flux regulation exposes the fitness burden associated with lactate production in Synechocystis sp. PCC6803","doi":"10.1021/acssynbio.6b00235","date_updated":"2021-01-12T08:01:21Z","publication_identifier":{"issn":["21615063"]},"day":"17","year":"2017","oa_version":"None","date_created":"2018-12-11T11:46:56Z","scopus_import":1,"date_published":"2017-03-17T00:00:00Z","status":"public","publist_id":"7298","publication":"ACS Synthetic Biology","abstract":[{"lang":"eng","text":"Cyanobacteria are mostly engineered to be sustainable cell-factories by genetic manipulations alone. Here, by modulating the concentration of allosteric effectors, we focus on increasing product formation without further burdening the cells with increased expression of enzymes. Resorting to a novel 96-well microplate cultivation system for cyanobacteria, and using lactate-producing strains of Synechocystis PCC6803 expressing different l-lactate dehydrogenases (LDH), we titrated the effect of 2,5-anhydro-mannitol supplementation. The latter acts in cells as a nonmetabolizable analogue of fructose 1,6-bisphosphate, a known allosteric regulator of one of the tested LDHs. In this strain (SAA023), we achieved over 2-fold increase of lactate productivity. Furthermore, we observed that as carbon is increasingly deviated during growth toward product formation, there is an increased fixation rate in the population of spontaneous mutants harboring an impaired production pathway. This is a challenge in the development of green cell factories, which may be countered by the incorporation in biotechnological processes of strategies such as the one pioneered here."}],"intvolume":"         6","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","pmid":1,"quality_controlled":"1","department":[{"_id":"ToBo"}],"publisher":"American Chemical Society","publication_status":"published","volume":6,"type":"journal_article"},{"author":[{"full_name":"Austin, Kyle","first_name":"Kyle","last_name":"Austin"},{"id":"2E36B656-F248-11E8-B48F-1D18A9856A87","first_name":"Ziga","last_name":"Virk","full_name":"Virk, Ziga"}],"oa_version":"Submitted Version","month":"01","citation":{"mla":"Austin, Kyle, and Ziga Virk. “Higson Compactification and Dimension Raising.” <i>Topology and Its Applications</i>, vol. 215, Elsevier, 2017, pp. 45–57, doi:<a href=\"https://doi.org/10.1016/j.topol.2016.10.005\">10.1016/j.topol.2016.10.005</a>.","short":"K. Austin, Z. Virk, Topology and Its Applications 215 (2017) 45–57.","ieee":"K. Austin and Z. Virk, “Higson compactification and dimension raising,” <i>Topology and its Applications</i>, vol. 215. Elsevier, pp. 45–57, 2017.","chicago":"Austin, Kyle, and Ziga Virk. “Higson Compactification and Dimension Raising.” <i>Topology and Its Applications</i>. Elsevier, 2017. <a href=\"https://doi.org/10.1016/j.topol.2016.10.005\">https://doi.org/10.1016/j.topol.2016.10.005</a>.","apa":"Austin, K., &#38; Virk, Z. (2017). Higson compactification and dimension raising. <i>Topology and Its Applications</i>. Elsevier. <a href=\"https://doi.org/10.1016/j.topol.2016.10.005\">https://doi.org/10.1016/j.topol.2016.10.005</a>","ista":"Austin K, Virk Z. 2017. Higson compactification and dimension raising. Topology and its Applications. 215, 45–57.","ama":"Austin K, Virk Z. Higson compactification and dimension raising. <i>Topology and its Applications</i>. 2017;215:45-57. doi:<a href=\"https://doi.org/10.1016/j.topol.2016.10.005\">10.1016/j.topol.2016.10.005</a>"},"date_created":"2018-12-11T11:46:56Z","publist_id":"7299","publication":"Topology and its Applications","status":"public","date_published":"2017-01-01T00:00:00Z","page":"45 - 57","abstract":[{"text":"Let X and Y be proper metric spaces. We show that a coarsely n-to-1 map f:X→Y induces an n-to-1 map of Higson coronas. This viewpoint turns out to be successful in showing that the classical dimension raising theorems hold in large scale; that is, if f:X→Y is a coarsely n-to-1 map between proper metric spaces X and Y then asdim(Y)≤asdim(X)+n−1. Furthermore we introduce coarsely open coarsely n-to-1 maps, which include the natural quotient maps via a finite group action, and prove that they preserve the asymptotic dimension.","lang":"eng"}],"_id":"521","intvolume":"       215","language":[{"iso":"eng"}],"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","quality_controlled":"1","doi":"10.1016/j.topol.2016.10.005","title":"Higson compactification and dimension raising","department":[{"_id":"HeEd"}],"date_updated":"2021-01-12T08:01:21Z","publisher":"Elsevier","day":"01","publication_identifier":{"issn":["01668641"]},"publication_status":"published","year":"2017","main_file_link":[{"url":"https://arxiv.org/abs/1608.03954v1","open_access":"1"}],"oa":1,"type":"journal_article","volume":215},{"title":"Finding non-orientable surfaces in 3-Manifolds","doi":"10.1007/s00454-017-9900-0","external_id":{"arxiv":["1602.07907"]},"publication_identifier":{"issn":["01795376"]},"day":"09","date_updated":"2023-02-21T17:01:34Z","related_material":{"record":[{"relation":"earlier_version","id":"1379","status":"public"}]},"year":"2017","article_processing_charge":"No","oa":1,"month":"06","author":[{"full_name":"Burton, Benjamin","last_name":"Burton","first_name":"Benjamin"},{"full_name":"De Mesmay, Arnaud N","id":"3DB2F25C-F248-11E8-B48F-1D18A9856A87","last_name":"De Mesmay","first_name":"Arnaud N"},{"id":"36690CA2-F248-11E8-B48F-1D18A9856A87","last_name":"Wagner","first_name":"Uli","orcid":"0000-0002-1494-0568","full_name":"Wagner, Uli"}],"article_type":"original","citation":{"ista":"Burton B, de Mesmay AN, Wagner U. 2017. Finding non-orientable surfaces in 3-Manifolds. Discrete &#38; Computational Geometry. 58(4), 871–888.","apa":"Burton, B., de Mesmay, A. N., &#38; Wagner, U. (2017). Finding non-orientable surfaces in 3-Manifolds. <i>Discrete &#38; Computational Geometry</i>. Springer. <a href=\"https://doi.org/10.1007/s00454-017-9900-0\">https://doi.org/10.1007/s00454-017-9900-0</a>","ama":"Burton B, de Mesmay AN, Wagner U. Finding non-orientable surfaces in 3-Manifolds. <i>Discrete &#38; Computational Geometry</i>. 2017;58(4):871-888. doi:<a href=\"https://doi.org/10.1007/s00454-017-9900-0\">10.1007/s00454-017-9900-0</a>","short":"B. Burton, A.N. de Mesmay, U. Wagner, Discrete &#38; Computational Geometry 58 (2017) 871–888.","mla":"Burton, Benjamin, et al. “Finding Non-Orientable Surfaces in 3-Manifolds.” <i>Discrete &#38; Computational Geometry</i>, vol. 58, no. 4, Springer, 2017, pp. 871–88, doi:<a href=\"https://doi.org/10.1007/s00454-017-9900-0\">10.1007/s00454-017-9900-0</a>.","chicago":"Burton, Benjamin, Arnaud N de Mesmay, and Uli Wagner. “Finding Non-Orientable Surfaces in 3-Manifolds.” <i>Discrete &#38; Computational Geometry</i>. Springer, 2017. <a href=\"https://doi.org/10.1007/s00454-017-9900-0\">https://doi.org/10.1007/s00454-017-9900-0</a>.","ieee":"B. Burton, A. N. de Mesmay, and U. Wagner, “Finding non-orientable surfaces in 3-Manifolds,” <i>Discrete &#38; Computational Geometry</i>, vol. 58, no. 4. Springer, pp. 871–888, 2017."},"arxiv":1,"page":"871 - 888","issue":"4","_id":"534","language":[{"iso":"eng"}],"department":[{"_id":"UlWa"}],"quality_controlled":"1","publication_status":"published","publisher":"Springer","main_file_link":[{"open_access":"1","url":"https://arxiv.org/abs/1602.07907"}],"volume":58,"type":"journal_article","oa_version":"Preprint","scopus_import":1,"date_created":"2018-12-11T11:47:01Z","abstract":[{"text":"We investigate the complexity of finding an embedded non-orientable surface of Euler genus g in a triangulated 3-manifold. This problem occurs both as a natural question in low-dimensional topology, and as a first non-trivial instance of embeddability of complexes into 3-manifolds. We prove that the problem is NP-hard, thus adding to the relatively few hardness results that are currently known in 3-manifold topology. In addition, we show that the problem lies in NP when the Euler genus g is odd, and we give an explicit algorithm in this case.","lang":"eng"}],"date_published":"2017-06-09T00:00:00Z","status":"public","publist_id":"7283","publication":"Discrete & Computational Geometry","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","intvolume":"        58"},{"year":"2017","ec_funded":1,"has_accepted_license":"1","oa":1,"doi":"10.1002/ange.201611998","title":"Grünlicht-induzierte Rezeptorinaktivierung durch Cobalamin-bindende Domänen","date_updated":"2021-01-12T08:01:33Z","day":"20","issue":"16","page":"4679 - 4682","language":[{"iso":"eng"}],"_id":"538","pubrep_id":"932","author":[{"id":"32CFBA64-F248-11E8-B48F-1D18A9856A87","first_name":"Stephanie","last_name":"Kainrath","full_name":"Kainrath, Stephanie"},{"full_name":"Stadler, Manuela","first_name":"Manuela","last_name":"Stadler"},{"full_name":"Gschaider-Reichhart, Eva","orcid":"0000-0002-7218-7738","first_name":"Eva","last_name":"Gschaider-Reichhart","id":"3FEE232A-F248-11E8-B48F-1D18A9856A87"},{"first_name":"Martin","last_name":"Distel","full_name":"Distel, Martin"},{"full_name":"Janovjak, Harald L","orcid":"0000-0002-8023-9315","last_name":"Janovjak","first_name":"Harald L","id":"33BA6C30-F248-11E8-B48F-1D18A9856A87"}],"file":[{"relation":"main_file","file_name":"IST-2018-932-v1+1_Kainrath_et_al-2017-Angewandte_Chemie.pdf","creator":"system","checksum":"d66fee867e7cdbfa3fe276c2fb0778bb","content_type":"application/pdf","access_level":"open_access","date_created":"2018-12-12T10:13:24Z","date_updated":"2020-07-14T12:46:39Z","file_size":1668557,"file_id":"5007"}],"month":"05","file_date_updated":"2020-07-14T12:46:39Z","ddc":["571"],"citation":{"apa":"Kainrath, S., Stadler, M., Gschaider-Reichhart, E., Distel, M., &#38; Janovjak, H. L. (2017). Grünlicht-induzierte Rezeptorinaktivierung durch Cobalamin-bindende Domänen. <i>Angewandte Chemie</i>. Wiley. <a href=\"https://doi.org/10.1002/ange.201611998\">https://doi.org/10.1002/ange.201611998</a>","ista":"Kainrath S, Stadler M, Gschaider-Reichhart E, Distel M, Janovjak HL. 2017. Grünlicht-induzierte Rezeptorinaktivierung durch Cobalamin-bindende Domänen. Angewandte Chemie. 129(16), 4679–4682.","ama":"Kainrath S, Stadler M, Gschaider-Reichhart E, Distel M, Janovjak HL. Grünlicht-induzierte Rezeptorinaktivierung durch Cobalamin-bindende Domänen. <i>Angewandte Chemie</i>. 2017;129(16):4679-4682. doi:<a href=\"https://doi.org/10.1002/ange.201611998\">10.1002/ange.201611998</a>","short":"S. Kainrath, M. Stadler, E. Gschaider-Reichhart, M. Distel, H.L. Janovjak, Angewandte Chemie 129 (2017) 4679–4682.","mla":"Kainrath, Stephanie, et al. “Grünlicht-Induzierte Rezeptorinaktivierung Durch Cobalamin-Bindende Domänen.” <i>Angewandte Chemie</i>, vol. 129, no. 16, Wiley, 2017, pp. 4679–82, doi:<a href=\"https://doi.org/10.1002/ange.201611998\">10.1002/ange.201611998</a>.","ieee":"S. Kainrath, M. Stadler, E. Gschaider-Reichhart, M. Distel, and H. L. Janovjak, “Grünlicht-induzierte Rezeptorinaktivierung durch Cobalamin-bindende Domänen,” <i>Angewandte Chemie</i>, vol. 129, no. 16. Wiley, pp. 4679–4682, 2017.","chicago":"Kainrath, Stephanie, Manuela Stadler, Eva Gschaider-Reichhart, Martin Distel, and Harald L Janovjak. “Grünlicht-Induzierte Rezeptorinaktivierung Durch Cobalamin-Bindende Domänen.” <i>Angewandte Chemie</i>. Wiley, 2017. <a href=\"https://doi.org/10.1002/ange.201611998\">https://doi.org/10.1002/ange.201611998</a>."},"type":"journal_article","volume":129,"quality_controlled":"1","project":[{"grant_number":"303564","name":"Microbial Ion Channels for Synthetic Neurobiology","_id":"25548C20-B435-11E9-9278-68D0E5697425","call_identifier":"FP7"},{"name":"Molecular Drug Targets","_id":"255A6082-B435-11E9-9278-68D0E5697425","grant_number":"W1232-B24","call_identifier":"FWF"}],"department":[{"_id":"CaGu"},{"_id":"HaJa"}],"publisher":"Wiley","publication_status":"published","publication":"Angewandte Chemie","publist_id":"7279","date_published":"2017-05-20T00:00:00Z","status":"public","abstract":[{"lang":"ger","text":"Optogenetik und Photopharmakologie ermöglichen präzise räumliche und zeitliche Kontrolle von Proteinwechselwirkung und -funktion in Zellen und Tieren. Optogenetische Methoden, die auf grünes Licht ansprechen und zum Trennen von Proteinkomplexen geeignet sind, sind nichtweitläufig verfügbar, würden jedoch mehrfarbige Experimente zur Beantwortung von biologischen Fragestellungen ermöglichen. Hier demonstrieren wir die Verwendung von Cobalamin(Vitamin B12)-bindenden Domänen von bakteriellen CarH-Transkriptionsfaktoren zur Grünlicht-induzierten Dissoziation von Rezeptoren. Fusioniert mit dem Fibroblasten-W achstumsfaktor-Rezeptor 1 führten diese im Dunkeln in kultivierten Zellen zu Signalaktivität durch Oligomerisierung, welche durch Beleuchten umgehend aufgehoben wurde. In Zebrafischembryonen, die einen derartigen Rezeptor exprimieren, ermöglichte grünes Licht die Kontrolle über abnormale Signalaktivität während der Embryonalentwicklung. "}],"tmp":{"name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","short":"CC BY (4.0)","image":"/images/cc_by.png"},"intvolume":"       129","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","oa_version":"Published Version","date_created":"2018-12-11T11:47:02Z"},{"language":[{"iso":"eng"}],"_id":"1216","intvolume":"        68","acknowledgement":"The authors acknowledge funding of the German Re-\r\nsearch  Foundation  (DFG)  via  the  Collaborative  Re-\r\nsearch  Center  (SFB  557)  \\Control  of  Complex  Turbu-\r\nlent  Shear  Flows\"  and  the  Emmy  Noether  Program.\r\nFurther  funding  was  provided  by  the  Zuse  Institute\r\nBerlin  (ZIB),  the  DFG-CNRS  research  group  \\Noise\r\nGeneration in Turbulent Flows\" (2003{2010), the Chaire\r\nd'Excellence 'Closed-loop control of turbulent shear  ows\r\nusing reduced-order models' (TUCOROM) of the French\r\nAgence Nationale de la Recherche (ANR), and the Eu-\r\nropean  Social  Fund  (ESF  App.   No.   100098251).   We\r\nthank  the  Ambrosys  Ltd.  Society  for  Complex  Sys-\r\ntems  Management  and  the  Bernd  R.  Noack  Cybernet-\r\nics  Foundation  for  additional  support.   A  part  of  this\r\nwork was performed using HPC resources from GENCI-[CCRT/CINES/IDRIS]  supported  by  the  Grant  2011-\r\n[x2011020912","user_id":"3E5EF7F0-F248-11E8-B48F-1D18A9856A87","publication":"Archives of Mechanics","publist_id":"6118","issue":"1","status":"public","date_published":"2016-01-01T00:00:00Z","page":"55 - 80","abstract":[{"lang":"eng","text":"A framework fo r extracting features in 2D transient flows, based on the acceleration field to ensure Galilean invariance is proposed in this paper. The minima of the acceleration magnitude (a superset of acceleration zeros) are extracted and discriminated into vortices and saddle points, based on the spectral properties of the velocity Jacobian. The extraction of topological features is performed with purely combinatorial algorithms from discrete computational topology. The feature points are prioritized with persistence, as a physically meaningful importance measure. These feature points are tracked in time with a robust algorithm for tracking features. Thus, a space-time hierarchy of the minima is built and vortex merging events are detected. We apply the acceleration feature extraction strategy to three two-dimensional shear flows: (1) an incompressible periodic cylinder wake, (2) an incompressible planar mixing layer and (3) a weakly compressible planar jet. The vortex-like acceleration feature points are shown to be well aligned with acceleration zeros, maxima of the vorticity magnitude, minima of the pressure field and minima of λ2."}],"date_created":"2018-12-11T11:50:46Z","citation":{"ista":"Kasten J, Reininghaus J, Hotz I, Hege H, Noack B, Daviller G, Morzyński M. 2016. Acceleration feature points of unsteady shear flows. Archives of Mechanics. 68(1), 55–80.","apa":"Kasten, J., Reininghaus, J., Hotz, I., Hege, H., Noack, B., Daviller, G., &#38; Morzyński, M. (2016). Acceleration feature points of unsteady shear flows. <i>Archives of Mechanics</i>. Polish Academy of Sciences Publishing House.","ama":"Kasten J, Reininghaus J, Hotz I, et al. Acceleration feature points of unsteady shear flows. <i>Archives of Mechanics</i>. 2016;68(1):55-80.","short":"J. Kasten, J. Reininghaus, I. Hotz, H. Hege, B. Noack, G. Daviller, M. Morzyński, Archives of Mechanics 68 (2016) 55–80.","mla":"Kasten, Jens, et al. “Acceleration Feature Points of Unsteady Shear Flows.” <i>Archives of Mechanics</i>, vol. 68, no. 1, Polish Academy of Sciences Publishing House, 2016, pp. 55–80.","chicago":"Kasten, Jens, Jan Reininghaus, Ingrid Hotz, Hans Hege, Bernd Noack, Guillaume Daviller, and Marek Morzyński. “Acceleration Feature Points of Unsteady Shear Flows.” <i>Archives of Mechanics</i>. Polish Academy of Sciences Publishing House, 2016.","ieee":"J. Kasten <i>et al.</i>, “Acceleration feature points of unsteady shear flows,” <i>Archives of Mechanics</i>, vol. 68, no. 1. Polish Academy of Sciences Publishing House, pp. 55–80, 2016."},"scopus_import":1,"author":[{"first_name":"Jens","last_name":"Kasten","full_name":"Kasten, Jens"},{"full_name":"Reininghaus, Jan","last_name":"Reininghaus","first_name":"Jan","id":"4505473A-F248-11E8-B48F-1D18A9856A87"},{"full_name":"Hotz, Ingrid","first_name":"Ingrid","last_name":"Hotz"},{"last_name":"Hege","first_name":"Hans","full_name":"Hege, Hans"},{"first_name":"Bernd","last_name":"Noack","full_name":"Noack, Bernd"},{"full_name":"Daviller, Guillaume","first_name":"Guillaume","last_name":"Daviller"},{"last_name":"Morzyński","first_name":"Marek","full_name":"Morzyński, Marek"}],"oa_version":"Published Version","month":"01","oa":1,"type":"journal_article","volume":68,"main_file_link":[{"open_access":"1","url":"http://am.ippt.pan.pl/am/article/viewFile/v68p55/pdf"}],"year":"2016","date_updated":"2021-01-12T06:49:09Z","publisher":"Polish Academy of Sciences Publishing House","day":"01","publication_status":"published","quality_controlled":"1","department":[{"_id":"HeEd"}],"title":"Acceleration feature points of unsteady shear flows"},{"author":[{"first_name":"Vinatha","last_name":"Sreeramkumar","full_name":"Sreeramkumar, Vinatha"},{"orcid":"0000-0002-6625-3348","full_name":"Hons, Miroslav","id":"4167FE56-F248-11E8-B48F-1D18A9856A87","first_name":"Miroslav","last_name":"Hons"},{"last_name":"Punzón","first_name":"Carmen","full_name":"Punzón, Carmen"},{"full_name":"Stein, Jens","first_name":"Jens","last_name":"Stein"},{"first_name":"David","last_name":"Sancho","full_name":"Sancho, David"},{"first_name":"Manuel","last_name":"Fresno Forcelledo","full_name":"Fresno Forcelledo, Manuel"},{"last_name":"Cuesta","first_name":"Natalia","full_name":"Cuesta, Natalia"}],"oa_version":"None","month":"01","scopus_import":1,"citation":{"ama":"Sreeramkumar V, Hons M, Punzón C, et al. Efficient T-cell priming and activation requires signaling through prostaglandin E2 (EP) receptors. <i>Immunology and Cell Biology</i>. 2016;94(1):39-51. doi:<a href=\"https://doi.org/10.1038/icb.2015.62\">10.1038/icb.2015.62</a>","apa":"Sreeramkumar, V., Hons, M., Punzón, C., Stein, J., Sancho, D., Fresno Forcelledo, M., &#38; Cuesta, N. (2016). Efficient T-cell priming and activation requires signaling through prostaglandin E2 (EP) receptors. <i>Immunology and Cell Biology</i>. Nature Publishing Group. <a href=\"https://doi.org/10.1038/icb.2015.62\">https://doi.org/10.1038/icb.2015.62</a>","ista":"Sreeramkumar V, Hons M, Punzón C, Stein J, Sancho D, Fresno Forcelledo M, Cuesta N. 2016. Efficient T-cell priming and activation requires signaling through prostaglandin E2 (EP) receptors. Immunology and Cell Biology. 94(1), 39–51.","ieee":"V. Sreeramkumar <i>et al.</i>, “Efficient T-cell priming and activation requires signaling through prostaglandin E2 (EP) receptors,” <i>Immunology and Cell Biology</i>, vol. 94, no. 1. Nature Publishing Group, pp. 39–51, 2016.","chicago":"Sreeramkumar, Vinatha, Miroslav Hons, Carmen Punzón, Jens Stein, David Sancho, Manuel Fresno Forcelledo, and Natalia Cuesta. “Efficient T-Cell Priming and Activation Requires Signaling through Prostaglandin E2 (EP) Receptors.” <i>Immunology and Cell Biology</i>. Nature Publishing Group, 2016. <a href=\"https://doi.org/10.1038/icb.2015.62\">https://doi.org/10.1038/icb.2015.62</a>.","mla":"Sreeramkumar, Vinatha, et al. “Efficient T-Cell Priming and Activation Requires Signaling through Prostaglandin E2 (EP) Receptors.” <i>Immunology and Cell Biology</i>, vol. 94, no. 1, Nature Publishing Group, 2016, pp. 39–51, doi:<a href=\"https://doi.org/10.1038/icb.2015.62\">10.1038/icb.2015.62</a>.","short":"V. Sreeramkumar, M. Hons, C. Punzón, J. Stein, D. Sancho, M. Fresno Forcelledo, N. Cuesta, Immunology and Cell Biology 94 (2016) 39–51."},"date_created":"2018-12-11T11:50:46Z","page":"39 - 51","abstract":[{"lang":"eng","text":"Understanding the regulation of T-cell responses during inflammation and auto-immunity is fundamental for designing efficient therapeutic strategies against immune diseases. In this regard, prostaglandin E 2 (PGE 2) is mostly considered a myeloid-derived immunosuppressive molecule. We describe for the first time that T cells secrete PGE 2 during T-cell receptor stimulation. In addition, we show that autocrine PGE 2 signaling through EP receptors is essential for optimal CD4 + T-cell activation in vitro and in vivo, and for T helper 1 (Th1) and regulatory T cell differentiation. PGE 2 was found to provide additive co-stimulatory signaling through AKT activation. Intravital multiphoton microscopy showed that triggering EP receptors in T cells is also essential for the stability of T cell-dendritic cell (DC) interactions and Th-cell accumulation in draining lymph nodes (LNs) during inflammation. We further demonstrated that blocking EP receptors in T cells during the initial phase of collagen-induced arthritis in mice resulted in a reduction of clinical arthritis. This could be attributable to defective T-cell activation, accompanied by a decline in activated and interferon-γ-producing CD4 + Th1 cells in draining LNs. In conclusion, we prove that T lymphocytes secret picomolar concentrations of PGE 2, which in turn provide additive co-stimulatory signaling, enabling T cells to attain a favorable activation threshold. PGE 2 signaling in T cells is also required for maintaining long and stable interactions with DCs within LNs. Blockade of EP receptors in vivo impairs T-cell activation and development of T cell-mediated inflammatory responses. This may have implications in various pathophysiological settings."}],"publication":"Immunology and Cell Biology","publist_id":"6116","issue":"1","date_published":"2016-01-01T00:00:00Z","status":"public","user_id":"3E5EF7F0-F248-11E8-B48F-1D18A9856A87","_id":"1217","intvolume":"        94","language":[{"iso":"eng"}],"acknowledgement":"This manuscript has been supported by grants SAF2007-61716 and S-SAL-0159/2006 awarded by the Spanish Ministry of Science and Education and the Community of Madrid to Dr M Fresno.","doi":"10.1038/icb.2015.62","department":[{"_id":"MiSi"}],"title":"Efficient T-cell priming and activation requires signaling through prostaglandin E2 (EP) receptors","quality_controlled":"1","day":"01","publication_status":"published","date_updated":"2021-01-12T06:49:09Z","publisher":"Nature Publishing Group","year":"2016","type":"journal_article","volume":94},{"date_updated":"2021-01-12T06:49:10Z","day":"01","title":"Culturing synechocystis sp. Strain pcc 6803 with N2 and CO2 in a diel regime reveals multiphase glycogen dynamics with low maintenance costs","doi":"10.1128/AEM.00256-16","oa":1,"year":"2016","citation":{"ama":"Angermayr A, Van Alphen P, Hasdemir D, et al. Culturing synechocystis sp. Strain pcc 6803 with N2 and CO2 in a diel regime reveals multiphase glycogen dynamics with low maintenance costs. <i>Applied and Environmental Microbiology</i>. 2016;82(14):4180-4189. doi:<a href=\"https://doi.org/10.1128/AEM.00256-16\">10.1128/AEM.00256-16</a>","apa":"Angermayr, A., Van Alphen, P., Hasdemir, D., Kramer, G., Iqbal, M., Van Grondelle, W., … Hellingwerf, K. (2016). Culturing synechocystis sp. Strain pcc 6803 with N2 and CO2 in a diel regime reveals multiphase glycogen dynamics with low maintenance costs. <i>Applied and Environmental Microbiology</i>. American Society for Microbiology. <a href=\"https://doi.org/10.1128/AEM.00256-16\">https://doi.org/10.1128/AEM.00256-16</a>","ista":"Angermayr A, Van Alphen P, Hasdemir D, Kramer G, Iqbal M, Van Grondelle W, Hoefsloot H, Choi Y, Hellingwerf K. 2016. Culturing synechocystis sp. Strain pcc 6803 with N2 and CO2 in a diel regime reveals multiphase glycogen dynamics with low maintenance costs. Applied and Environmental Microbiology. 82(14), 4180–4189.","ieee":"A. Angermayr <i>et al.</i>, “Culturing synechocystis sp. Strain pcc 6803 with N2 and CO2 in a diel regime reveals multiphase glycogen dynamics with low maintenance costs,” <i>Applied and Environmental Microbiology</i>, vol. 82, no. 14. American Society for Microbiology, pp. 4180–4189, 2016.","chicago":"Angermayr, Andreas, Pascal Van Alphen, Dicle Hasdemir, Gertjan Kramer, Muzamal Iqbal, Wilmar Van Grondelle, Huub Hoefsloot, Younghae Choi, and Klaas Hellingwerf. “Culturing Synechocystis Sp. Strain Pcc 6803 with N2 and CO2 in a Diel Regime Reveals Multiphase Glycogen Dynamics with Low Maintenance Costs.” <i>Applied and Environmental Microbiology</i>. American Society for Microbiology, 2016. <a href=\"https://doi.org/10.1128/AEM.00256-16\">https://doi.org/10.1128/AEM.00256-16</a>.","short":"A. Angermayr, P. Van Alphen, D. Hasdemir, G. Kramer, M. Iqbal, W. Van Grondelle, H. Hoefsloot, Y. Choi, K. Hellingwerf, Applied and Environmental Microbiology 82 (2016) 4180–4189.","mla":"Angermayr, Andreas, et al. “Culturing Synechocystis Sp. Strain Pcc 6803 with N2 and CO2 in a Diel Regime Reveals Multiphase Glycogen Dynamics with Low Maintenance Costs.” <i>Applied and Environmental Microbiology</i>, vol. 82, no. 14, American Society for Microbiology, 2016, pp. 4180–89, doi:<a href=\"https://doi.org/10.1128/AEM.00256-16\">10.1128/AEM.00256-16</a>."},"month":"07","author":[{"id":"4677C796-F248-11E8-B48F-1D18A9856A87","first_name":"Andreas","last_name":"Angermayr","full_name":"Angermayr, Andreas","orcid":"0000-0001-8619-2223"},{"first_name":"Pascal","last_name":"Van Alphen","full_name":"Van Alphen, Pascal"},{"full_name":"Hasdemir, Dicle","first_name":"Dicle","last_name":"Hasdemir"},{"first_name":"Gertjan","last_name":"Kramer","full_name":"Kramer, Gertjan"},{"last_name":"Iqbal","first_name":"Muzamal","full_name":"Iqbal, Muzamal"},{"full_name":"Van Grondelle, Wilmar","first_name":"Wilmar","last_name":"Van Grondelle"},{"last_name":"Hoefsloot","first_name":"Huub","full_name":"Hoefsloot, Huub"},{"full_name":"Choi, Younghae","last_name":"Choi","first_name":"Younghae"},{"full_name":"Hellingwerf, Klaas","first_name":"Klaas","last_name":"Hellingwerf"}],"acknowledgement":"Dutch Ministry of Economic Affairs, Agriculture, and Innovation through the program BioSolar CellsS. Andreas Angermayr,Pascal van Alphen, Klaas J. Hellingwerf\r\nWe thank Naira Quintana (presently at Rousselot, Belgium) for the ini-\r\ntiative  at  the  10th  Cyanobacterial  Molecular  Biology  Workshop\r\n(CMBW), June 2010, Lake Arrowhead, Los Angeles, CA, USA, to start the\r\ncollaborative endeavor reported here. We thank Timo Maarleveld from\r\nCWI/VU (Amsterdam) for a custom-made Python script handling the output from the NMR analysis and for evaluating and visualizing the\r\nseparate metabolites for their evaluation. We thank Rob Verpoorte from\r\nLeiden University (metabolome analysis) and Hans Aerts from the AMC\r\n(proteome analysis) for lab space and equipment. We thank Robert Leh-\r\nmann (Humboldt University Berlin) and Ilka Axmann (University of\r\nDüsseldorf) for sharing the R-code for the LOS transformation of the\r\ntranscript data. We thank Hans C. P. Matthijs from IBED for inspiring\r\ndialogues and insightful thoughts on continuous culturing of cyanobac-\r\nteria. We thank Sandra Waaijenborg for performing the transcript nor-\r\nmalization and Johan Westerhuis from BDA, Jeroen van der Steen and\r\nFilipe Branco dos Santos from MMP, and Lucas Stal from IBED/NIOZ for\r\nhelpful discussions. We thank Milou Schuurmans from MMP for help\r\nwith sampling and glycogen determination. We thank the members of the\r\nRNA Biology & Applied Bioinformatics group at SILS, in particular Selina\r\nvan Leeuwen, Elisa Hoekstra, and Martijs Jonker, for the microarray anal-\r\nysis. We thank the reviewers of this work for their insightful comments\r\nwhich improved the quality of the manuscript. This work, including the efforts of S. Andreas Angermayr, Pascal van\r\nAlphen, and Klaas J. Hellingwerf, was funded by Dutch Ministry of Eco-\r\nnomic Affairs, Agriculture, and Innovation through the program BioSolar\r\nCells.","language":[{"iso":"eng"}],"_id":"1218","issue":"14","page":"4180 - 4189","publisher":"American Society for Microbiology","publication_status":"published","quality_controlled":"1","department":[{"_id":"ToBo"}],"volume":82,"type":"journal_article","main_file_link":[{"open_access":"1","url":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4959195/"}],"date_created":"2018-12-11T11:50:46Z","scopus_import":1,"oa_version":"Submitted Version","intvolume":"        82","user_id":"3E5EF7F0-F248-11E8-B48F-1D18A9856A87","date_published":"2016-07-01T00:00:00Z","status":"public","publication":"Applied and Environmental Microbiology","publist_id":"6117","abstract":[{"lang":"eng","text":"Investigating the physiology of cyanobacteria cultured under a diel light regime is relevant for a better understanding of the resulting growth characteristics and for specific biotechnological applications that are foreseen for these photosynthetic organisms. Here, we present the results of a multiomics study of the model cyanobacterium Synechocystis sp. strain PCC 6803, cultured in a lab-scale photobioreactor in physiological conditions relevant for large-scale culturing. The culture was sparged withN2 andCO2, leading to an anoxic environment during the dark period. Growth followed the availability of light. Metabolite analysis performed with 1Hnuclear magnetic resonance analysis showed that amino acids involved in nitrogen and sulfur assimilation showed elevated levels in the light. Most protein levels, analyzed through mass spectrometry, remained rather stable. However, several high-light-response proteins and stress-response proteins showed distinct changes at the onset of the light period. Microarray-based transcript analysis found common patterns of~56% of the transcriptome following the diel regime. These oscillating transcripts could be grouped coarsely into genes that were upregulated and downregulated in the dark period. The accumulated glycogen was degraded in the anaerobic environment in the dark. A small part was degraded gradually, reflecting basic maintenance requirements of the cells in darkness. Surprisingly, the largest part was degraded rapidly in a short time span at the end of the dark period. This degradation could allow rapid formation of metabolic intermediates at the end of the dark period, preparing the cells for the resumption of growth at the start of the light period."}]},{"scopus_import":1,"date_created":"2018-12-11T11:50:47Z","oa_version":"Preprint","user_id":"3E5EF7F0-F248-11E8-B48F-1D18A9856A87","intvolume":"        44","abstract":[{"text":"We consider N×N random matrices of the form H = W + V where W is a real symmetric or complex Hermitian Wigner matrix and V is a random or deterministic, real, diagonal matrix whose entries are independent of W. We assume subexponential decay for the matrix entries of W, and we choose V so that the eigenvalues ofW and V are typically of the same order. For a large class of diagonal matrices V , we show that the local statistics in the bulk of the spectrum are universal in the limit of large N.","lang":"eng"}],"publist_id":"6115","publication":"Annals of Probability","status":"public","date_published":"2016-01-01T00:00:00Z","publication_status":"published","publisher":"Institute of Mathematical Statistics","department":[{"_id":"LaEr"}],"quality_controlled":"1","project":[{"grant_number":"338804","_id":"258DCDE6-B435-11E9-9278-68D0E5697425","name":"Random matrices, universality and disordered quantum systems","call_identifier":"FP7"}],"type":"journal_article","volume":44,"main_file_link":[{"url":"https://arxiv.org/abs/1405.6634","open_access":"1"}],"citation":{"mla":"Lee, Jioon, et al. “Bulk Universality for Deformed Wigner Matrices.” <i>Annals of Probability</i>, vol. 44, no. 3, Institute of Mathematical Statistics, 2016, pp. 2349–425, doi:<a href=\"https://doi.org/10.1214/15-AOP1023\">10.1214/15-AOP1023</a>.","short":"J. Lee, K. Schnelli, B. Stetler, H. Yau, Annals of Probability 44 (2016) 2349–2425.","chicago":"Lee, Jioon, Kevin Schnelli, Ben Stetler, and Horngtzer Yau. “Bulk Universality for Deformed Wigner Matrices.” <i>Annals of Probability</i>. Institute of Mathematical Statistics, 2016. <a href=\"https://doi.org/10.1214/15-AOP1023\">https://doi.org/10.1214/15-AOP1023</a>.","ieee":"J. Lee, K. Schnelli, B. Stetler, and H. Yau, “Bulk universality for deformed wigner matrices,” <i>Annals of Probability</i>, vol. 44, no. 3. Institute of Mathematical Statistics, pp. 2349–2425, 2016.","ista":"Lee J, Schnelli K, Stetler B, Yau H. 2016. Bulk universality for deformed wigner matrices. Annals of Probability. 44(3), 2349–2425.","apa":"Lee, J., Schnelli, K., Stetler, B., &#38; Yau, H. (2016). Bulk universality for deformed wigner matrices. <i>Annals of Probability</i>. Institute of Mathematical Statistics. <a href=\"https://doi.org/10.1214/15-AOP1023\">https://doi.org/10.1214/15-AOP1023</a>","ama":"Lee J, Schnelli K, Stetler B, Yau H. Bulk universality for deformed wigner matrices. <i>Annals of Probability</i>. 2016;44(3):2349-2425. doi:<a href=\"https://doi.org/10.1214/15-AOP1023\">10.1214/15-AOP1023</a>"},"author":[{"last_name":"Lee","first_name":"Jioon","full_name":"Lee, Jioon"},{"last_name":"Schnelli","first_name":"Kevin","id":"434AD0AE-F248-11E8-B48F-1D18A9856A87","full_name":"Schnelli, Kevin","orcid":"0000-0003-0954-3231"},{"last_name":"Stetler","first_name":"Ben","full_name":"Stetler, Ben"},{"last_name":"Yau","first_name":"Horngtzer","full_name":"Yau, Horngtzer"}],"month":"01","language":[{"iso":"eng"}],"_id":"1219","acknowledgement":"J.C. was supported in part by National Research Foundation of Korea Grant 2011-0013474 and TJ Park Junior Faculty Fellowship.\r\nK.S. was supported by ERC Advanced Grant RANMAT, No. 338804, and the \"Fund for Math.\"\r\nB.S. was supported by NSF GRFP Fellowship DGE-1144152.\r\nH.Y. was supported in part by NSF Grant DMS-13-07444 and Simons investigator fellowship. We thank Paul Bourgade, László Erd ̋os and Antti Knowles for helpful comments. We are grateful to the Taida Institute for Mathematical\r\nSciences and National Taiwan Universality for their hospitality during part of this\r\nresearch. We thank Thomas Spencer and the Institute for Advanced Study for their\r\nhospitality during the academic year 2013–2014.  ","page":"2349 - 2425","issue":"3","day":"01","date_updated":"2021-01-12T06:49:10Z","doi":"10.1214/15-AOP1023","title":"Bulk universality for deformed wigner matrices","oa":1,"year":"2016","ec_funded":1},{"oa":1,"type":"conference","year":"2016","main_file_link":[{"url":"https://ntrs.nasa.gov/search.jsp?R=20160010167&amp;hterms=Fuselage+boundary+layer+ingestion+propulsion+applied+thin+haul+commuter+aircraft+optimal+efficiency&amp;qs=N%3D0%26Ntk%3DAll%26Ntt%3DFuselage%2520boundary%2520layer%2520ingestion%2520propulsion%2520applied%2520to%2520a%2520thin%2520haul%2520commuter%2520aircraft%2520for%2520optimal%2520efficiency%26Ntx%3Dmode%2520matchallpartial%26Nm%3D123%7CCollection%7CNASA%2520STI%7C%7C17%7CCollection%7CNACA","open_access":"1"}],"conference":{"location":"Washington, D.C., USA","name":"AIAA: Aviation Technology, Integration, and Operations Conference","start_date":"2016-06-13","end_date":"2016-06-17"},"publisher":"AIAA","date_updated":"2023-02-21T10:17:50Z","publication_status":"published","day":"01","quality_controlled":"1","department":[{"_id":"CaGu"},{"_id":"GaTk"}],"title":"Fuselage boundary layer ingestion propulsion applied to a thin haul commuter aircraft for optimal efficiency","doi":"10.2514/6.2016-3764","_id":"1220","language":[{"iso":"eng"}],"user_id":"3E5EF7F0-F248-11E8-B48F-1D18A9856A87","status":"public","date_published":"2016-06-01T00:00:00Z","publist_id":"6114","abstract":[{"text":"Theoretical and numerical aspects of aerodynamic efficiency of propulsion systems coupled to the boundary layer of a fuselage are studied. We discuss the effects of local flow fields, which are affected both by conservative flow acceleration as well as total pressure losses, on the efficiency of boundary layer immersed propulsion devices. We introduce the concept of a boundary layer retardation turbine that helps reduce skin friction over the fuselage. We numerically investigate efficiency gains offered by boundary layer and wake interacting devices. We discuss the results in terms of a total energy consumption framework and show that efficiency gains of any device depend on all the other elements of the propulsion system.","lang":"eng"}],"page":"1 - 19","citation":{"ama":"Mikić G, Stoll A, Bevirt J, Grah R, Moore M. Fuselage boundary layer ingestion propulsion applied to a thin haul commuter aircraft for optimal efficiency. In: AIAA; 2016:1-19. doi:<a href=\"https://doi.org/10.2514/6.2016-3764\">10.2514/6.2016-3764</a>","apa":"Mikić, G., Stoll, A., Bevirt, J., Grah, R., &#38; Moore, M. (2016). Fuselage boundary layer ingestion propulsion applied to a thin haul commuter aircraft for optimal efficiency (pp. 1–19). Presented at the AIAA: Aviation Technology, Integration, and Operations Conference, Washington, D.C., USA: AIAA. <a href=\"https://doi.org/10.2514/6.2016-3764\">https://doi.org/10.2514/6.2016-3764</a>","ista":"Mikić G, Stoll A, Bevirt J, Grah R, Moore M. 2016. Fuselage boundary layer ingestion propulsion applied to a thin haul commuter aircraft for optimal efficiency. AIAA: Aviation Technology, Integration, and Operations Conference, 1–19.","ieee":"G. Mikić, A. Stoll, J. Bevirt, R. Grah, and M. Moore, “Fuselage boundary layer ingestion propulsion applied to a thin haul commuter aircraft for optimal efficiency,” presented at the AIAA: Aviation Technology, Integration, and Operations Conference, Washington, D.C., USA, 2016, pp. 1–19.","chicago":"Mikić, Gregor, Alex Stoll, Joe Bevirt, Rok Grah, and Mark Moore. “Fuselage Boundary Layer Ingestion Propulsion Applied to a Thin Haul Commuter Aircraft for Optimal Efficiency,” 1–19. AIAA, 2016. <a href=\"https://doi.org/10.2514/6.2016-3764\">https://doi.org/10.2514/6.2016-3764</a>.","short":"G. Mikić, A. Stoll, J. Bevirt, R. Grah, M. Moore, in:, AIAA, 2016, pp. 1–19.","mla":"Mikić, Gregor, et al. <i>Fuselage Boundary Layer Ingestion Propulsion Applied to a Thin Haul Commuter Aircraft for Optimal Efficiency</i>. AIAA, 2016, pp. 1–19, doi:<a href=\"https://doi.org/10.2514/6.2016-3764\">10.2514/6.2016-3764</a>."},"date_created":"2018-12-11T11:50:47Z","scopus_import":1,"month":"06","oa_version":"Preprint","author":[{"full_name":"Mikić, Gregor","first_name":"Gregor","last_name":"Mikić"},{"first_name":"Alex","last_name":"Stoll","full_name":"Stoll, Alex"},{"first_name":"Joe","last_name":"Bevirt","full_name":"Bevirt, Joe"},{"orcid":"0000-0003-2539-3560","full_name":"Grah, Rok","id":"483E70DE-F248-11E8-B48F-1D18A9856A87","last_name":"Grah","first_name":"Rok"},{"full_name":"Moore, Mark","first_name":"Mark","last_name":"Moore"}]},{"type":"journal_article","volume":5,"publisher":"F1000 Research","publication_status":"published","quality_controlled":"1","project":[{"name":"Polarity and subcellular dynamics in plants","_id":"25716A02-B435-11E9-9278-68D0E5697425","grant_number":"282300","call_identifier":"FP7"}],"department":[{"_id":"JiFr"}],"tmp":{"name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","short":"CC BY (4.0)","image":"/images/cc_by.png"},"intvolume":"         5","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","publist_id":"6113","publication":"F1000 Research ","status":"public","date_published":"2016-01-20T00:00:00Z","abstract":[{"lang":"eng","text":"The Auxin Binding Protein 1 (ABP1) is one of the most studied proteins in plants. Since decades ago, it has been the prime receptor candidate for the plant hormone auxin with a plethora of described functions in auxin signaling and development. The developmental importance of ABP1 has recently been questioned by identification of Arabidopsis thaliana abp1 knock-out alleles that show no obvious phenotypes under normal growth conditions. In this study, we examined the contradiction between the normal growth and development of the abp1 knock-outs and the strong morphological defects observed in three different ethanol-inducible abp1 knock-down mutants ( abp1-AS, SS12K, SS12S). By analyzing segregating populations of abp1 knock-out vs. abp1 knock-down crosses we show that the strong morphological defects that were believed to be the result of conditional down-regulation of ABP1 can be reproduced also in the absence of the functional ABP1 protein. This data suggests that the phenotypes in abp1 knock-down lines are due to the off-target effects and asks for further reflections on the biological function of ABP1 or alternative explanations for the missing phenotypic defects in the abp1 loss-of-function alleles."}],"date_created":"2018-12-11T11:50:47Z","scopus_import":"1","oa_version":"Published Version","oa":1,"article_processing_charge":"No","year":"2016","ec_funded":1,"has_accepted_license":"1","date_updated":"2025-05-07T11:12:30Z","day":"20","doi":"10.12688/f1000research.7654.1","title":"Strong morphological defects in conditional Arabidopsis abp1 knock-down mutants generated in absence of functional ABP1 protein","_id":"1221","pubrep_id":"711","language":[{"iso":"eng"}],"acknowledgement":"This work was supported by ERC Independent Research grant (ERC-2011-StG-20101109-PSDP to JF). JM internship was supported by the grant “Action Austria – Slovakia”. MG was supported by the scholarship \"Stipendien der Stipendienstiftung der Republik Österreich\". Work by EH and CPR were supported by ANR blanc ANR-14-CE11-0018. We would like to thank Mark Estelle and Yunde Zhao for provid\r\n-\r\ning \r\nabp1-c1\r\n, \r\nabp1-TD1 \r\nand \r\nabp1-WTc1 \r\nseeds. We thank Emeline \r\nHuault for technical assistance.","ddc":["581"],"citation":{"ieee":"J. Michalko, M. Glanc, C. Perrot Rechenmann, and J. Friml, “Strong morphological defects in conditional Arabidopsis abp1 knock-down mutants generated in absence of functional ABP1 protein,” <i>F1000 Research </i>, vol. 5. F1000 Research, 2016.","chicago":"Michalko, Jaroslav, Matous Glanc, Catherine Perrot Rechenmann, and Jiří Friml. “Strong Morphological Defects in Conditional Arabidopsis Abp1 Knock-down Mutants Generated in Absence of Functional ABP1 Protein.” <i>F1000 Research </i>. F1000 Research, 2016. <a href=\"https://doi.org/10.12688/f1000research.7654.1\">https://doi.org/10.12688/f1000research.7654.1</a>.","mla":"Michalko, Jaroslav, et al. “Strong Morphological Defects in Conditional Arabidopsis Abp1 Knock-down Mutants Generated in Absence of Functional ABP1 Protein.” <i>F1000 Research </i>, vol. 5, 86, F1000 Research, 2016, doi:<a href=\"https://doi.org/10.12688/f1000research.7654.1\">10.12688/f1000research.7654.1</a>.","short":"J. Michalko, M. Glanc, C. Perrot Rechenmann, J. Friml, F1000 Research  5 (2016).","ama":"Michalko J, Glanc M, Perrot Rechenmann C, Friml J. Strong morphological defects in conditional Arabidopsis abp1 knock-down mutants generated in absence of functional ABP1 protein. <i>F1000 Research </i>. 2016;5. doi:<a href=\"https://doi.org/10.12688/f1000research.7654.1\">10.12688/f1000research.7654.1</a>","apa":"Michalko, J., Glanc, M., Perrot Rechenmann, C., &#38; Friml, J. (2016). Strong morphological defects in conditional Arabidopsis abp1 knock-down mutants generated in absence of functional ABP1 protein. <i>F1000 Research </i>. F1000 Research. <a href=\"https://doi.org/10.12688/f1000research.7654.1\">https://doi.org/10.12688/f1000research.7654.1</a>","ista":"Michalko J, Glanc M, Perrot Rechenmann C, Friml J. 2016. Strong morphological defects in conditional Arabidopsis abp1 knock-down mutants generated in absence of functional ABP1 protein. F1000 Research . 5, 86."},"article_type":"original","author":[{"full_name":"Michalko, Jaroslav","first_name":"Jaroslav","last_name":"Michalko","id":"483727CA-F248-11E8-B48F-1D18A9856A87"},{"id":"1AE1EA24-02D0-11E9-9BAA-DAF4881429F2","last_name":"Glanc","first_name":"Matous","full_name":"Glanc, Matous","orcid":"0000-0003-0619-7783"},{"full_name":"Perrot Rechenmann, Catherine","last_name":"Perrot Rechenmann","first_name":"Catherine"},{"id":"4159519E-F248-11E8-B48F-1D18A9856A87","first_name":"Jirí","last_name":"Friml","full_name":"Friml, Jirí","orcid":"0000-0002-8302-7596"}],"file":[{"content_type":"application/pdf","creator":"system","checksum":"c9e50bb6096a7ba4a832969935820f19","relation":"main_file","file_name":"IST-2016-711-v1+1_770cf1e0-612f-4e85-a500-54b6349fbbab_7654_-_jaroslav_michalko.pdf","file_id":"5154","file_size":2990459,"date_created":"2018-12-12T10:15:33Z","date_updated":"2020-07-14T12:44:39Z","access_level":"open_access"}],"file_date_updated":"2020-07-14T12:44:39Z","month":"01","article_number":"86"},{"volume":55,"type":"journal_article","main_file_link":[{"open_access":"1","url":"https://arxiv.org/abs/1212.0649"}],"publisher":"Springer","publication_status":"published","quality_controlled":"1","department":[{"_id":"HeEd"}],"intvolume":"        55","user_id":"3E5EF7F0-F248-11E8-B48F-1D18A9856A87","date_published":"2016-01-01T00:00:00Z","status":"public","publication":"Discrete & Computational Geometry","publist_id":"6111","abstract":[{"lang":"eng","text":"We consider packings of congruent circles on a square flat torus, i.e., periodic (w.r.t. a square lattice) planar circle packings, with the maximal circle radius. This problem is interesting due to a practical reason—the problem of “super resolution of images.” We have found optimal arrangements for N=6, 7 and 8 circles. Surprisingly, for the case N=7 there are three different optimal arrangements. Our proof is based on a computer enumeration of toroidal irreducible contact graphs."}],"date_created":"2018-12-11T11:50:48Z","scopus_import":1,"oa_version":"Preprint","oa":1,"year":"2016","date_updated":"2021-01-12T06:49:11Z","day":"01","title":"Optimal packings of congruent circles on a square flat torus","doi":"10.1007/s00454-015-9742-6","acknowledgement":"We wish to thank Alexey Tarasov, Vladislav Volkov and Brittany Fasy for some useful comments and remarks, and especially Thom Sulanke for modifying surftri to suit our purposes. Oleg R. Musin was partially supported by the NSF Grant DMS-1400876 and by the RFBR Grant 15-01-99563. Anton V. Nikitenko was supported by the Chebyshev Laboratory (Department of Mathematics and Mechanics, St. Petersburg State University) under RF Government Grant 11.G34.31.0026.","_id":"1222","language":[{"iso":"eng"}],"issue":"1","page":"1 - 20","citation":{"ama":"Musin O, Nikitenko A. Optimal packings of congruent circles on a square flat torus. <i>Discrete &#38; Computational Geometry</i>. 2016;55(1):1-20. doi:<a href=\"https://doi.org/10.1007/s00454-015-9742-6\">10.1007/s00454-015-9742-6</a>","ista":"Musin O, Nikitenko A. 2016. Optimal packings of congruent circles on a square flat torus. Discrete &#38; Computational Geometry. 55(1), 1–20.","apa":"Musin, O., &#38; Nikitenko, A. (2016). Optimal packings of congruent circles on a square flat torus. <i>Discrete &#38; Computational Geometry</i>. Springer. <a href=\"https://doi.org/10.1007/s00454-015-9742-6\">https://doi.org/10.1007/s00454-015-9742-6</a>","chicago":"Musin, Oleg, and Anton Nikitenko. “Optimal Packings of Congruent Circles on a Square Flat Torus.” <i>Discrete &#38; Computational Geometry</i>. Springer, 2016. <a href=\"https://doi.org/10.1007/s00454-015-9742-6\">https://doi.org/10.1007/s00454-015-9742-6</a>.","ieee":"O. Musin and A. Nikitenko, “Optimal packings of congruent circles on a square flat torus,” <i>Discrete &#38; Computational Geometry</i>, vol. 55, no. 1. Springer, pp. 1–20, 2016.","mla":"Musin, Oleg, and Anton Nikitenko. “Optimal Packings of Congruent Circles on a Square Flat Torus.” <i>Discrete &#38; Computational Geometry</i>, vol. 55, no. 1, Springer, 2016, pp. 1–20, doi:<a href=\"https://doi.org/10.1007/s00454-015-9742-6\">10.1007/s00454-015-9742-6</a>.","short":"O. Musin, A. Nikitenko, Discrete &#38; Computational Geometry 55 (2016) 1–20."},"month":"01","author":[{"full_name":"Musin, Oleg","last_name":"Musin","first_name":"Oleg"},{"full_name":"Nikitenko, Anton","last_name":"Nikitenko","first_name":"Anton","id":"3E4FF1BA-F248-11E8-B48F-1D18A9856A87"}]},{"type":"journal_article","volume":6,"oa":1,"main_file_link":[{"url":"https://arxiv.org/abs/1408.3961","open_access":"1"}],"year":"2016","day":"01","publication_status":"published","date_updated":"2021-01-12T06:49:12Z","publisher":"European Mathematical Society","doi":"10.4171/JST/132","title":"Localization for transversally periodic random potentials on binary trees","department":[{"_id":"LaEr"}],"quality_controlled":"1","user_id":"3E5EF7F0-F248-11E8-B48F-1D18A9856A87","_id":"1223","intvolume":"         6","language":[{"iso":"eng"}],"page":"557 - 600","abstract":[{"text":"We consider a random Schrödinger operator on the binary tree with a random potential which is the sum of a random radially symmetric potential, Qr, and a random transversally periodic potential, κQt, with coupling constant κ. Using a new one-dimensional dynamical systems approach combined with Jensen's inequality in hyperbolic space (our key estimate) we obtain a fractional moment estimate proving localization for small and large κ. Together with a previous result we therefore obtain a model with two Anderson transitions, from localization to delocalization and back to localization, when increasing κ. As a by-product we also have a partially new proof of one-dimensional Anderson localization at any disorder.","lang":"eng"}],"publication":"Journal of Spectral Theory","issue":"3","publist_id":"6112","date_published":"2016-01-01T00:00:00Z","status":"public","scopus_import":1,"date_created":"2018-12-11T11:50:48Z","citation":{"ieee":"R. Froese, D. Lee, C. Sadel, W. Spitzer, and G. Stolz, “Localization for transversally periodic random potentials on binary trees,” <i>Journal of Spectral Theory</i>, vol. 6, no. 3. European Mathematical Society, pp. 557–600, 2016.","chicago":"Froese, Richard, Darrick Lee, Christian Sadel, Wolfgang Spitzer, and Günter Stolz. “Localization for Transversally Periodic Random Potentials on Binary Trees.” <i>Journal of Spectral Theory</i>. European Mathematical Society, 2016. <a href=\"https://doi.org/10.4171/JST/132\">https://doi.org/10.4171/JST/132</a>.","short":"R. Froese, D. Lee, C. Sadel, W. Spitzer, G. Stolz, Journal of Spectral Theory 6 (2016) 557–600.","mla":"Froese, Richard, et al. “Localization for Transversally Periodic Random Potentials on Binary Trees.” <i>Journal of Spectral Theory</i>, vol. 6, no. 3, European Mathematical Society, 2016, pp. 557–600, doi:<a href=\"https://doi.org/10.4171/JST/132\">10.4171/JST/132</a>.","ama":"Froese R, Lee D, Sadel C, Spitzer W, Stolz G. Localization for transversally periodic random potentials on binary trees. <i>Journal of Spectral Theory</i>. 2016;6(3):557-600. doi:<a href=\"https://doi.org/10.4171/JST/132\">10.4171/JST/132</a>","apa":"Froese, R., Lee, D., Sadel, C., Spitzer, W., &#38; Stolz, G. (2016). Localization for transversally periodic random potentials on binary trees. <i>Journal of Spectral Theory</i>. European Mathematical Society. <a href=\"https://doi.org/10.4171/JST/132\">https://doi.org/10.4171/JST/132</a>","ista":"Froese R, Lee D, Sadel C, Spitzer W, Stolz G. 2016. Localization for transversally periodic random potentials on binary trees. Journal of Spectral Theory. 6(3), 557–600."},"oa_version":"Preprint","author":[{"first_name":"Richard","last_name":"Froese","full_name":"Froese, Richard"},{"first_name":"Darrick","last_name":"Lee","full_name":"Lee, Darrick"},{"id":"4760E9F8-F248-11E8-B48F-1D18A9856A87","last_name":"Sadel","first_name":"Christian","full_name":"Sadel, Christian","orcid":"0000-0001-8255-3968"},{"first_name":"Wolfgang","last_name":"Spitzer","full_name":"Spitzer, Wolfgang"},{"last_name":"Stolz","first_name":"Günter","full_name":"Stolz, Günter"}],"month":"01"},{"page":"98 - 103","abstract":[{"lang":"eng","text":"Sexual dimorphism in resource allocation is expected to change during the life cycle of dioecious plants because of temporal differences between the sexes in reproductive investment. Given the potential for sex-specific differences in reproductive costs, resource availability may contribute to variation in reproductive allocation in females and males. Here, we used Rumex hastatulus, a dioecious, wind-pollinated annual plant, to investigate whether sexual dimorphism varies with life-history stage and nutrient availability, and determine whether allocation patterns differ depending on reproductive commitment. To examine if the costs of reproduction varied between the sexes, reproduction was either allowed or prevented through bud removal, and biomass allocation was measured at maturity. In a second experiment to assess variation in sexual dimorphism across the life cycle, and whether this varied with resource availability, plants were grown in high and low nutrients and allocation to roots, aboveground vegetative growth and reproduction were measured at three developmental stages. Males prevented from reproducing compensated with increased above- and belowground allocation to a much larger degree than females, suggesting that male reproductive costs reduce vegetative growth. The proportional allocation to roots, reproductive structures and aboveground vegetative growth varied between the sexes and among life-cycle stages, but not with nutrient treatment. Females allocated proportionally more resources to roots than males at peak flowering, but this pattern was reversed at reproductive maturity under low-nutrient conditions. Our study illustrates the importance of temporal dynamics in sex-specific resource allocation and provides support for high male reproductive costs in wind-pollinated plants."}],"issue":"1","publication":"Plant Biology","publist_id":"6110","date_published":"2016-01-01T00:00:00Z","status":"public","user_id":"3E5EF7F0-F248-11E8-B48F-1D18A9856A87","_id":"1224","intvolume":"        18","language":[{"iso":"eng"}],"oa_version":"None","author":[{"full_name":"Teitel, Zachary","first_name":"Zachary","last_name":"Teitel"},{"first_name":"Melinda","last_name":"Pickup","id":"2C78037E-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0001-6118-0541","full_name":"Pickup, Melinda"},{"last_name":"Field","first_name":"David","id":"419049E2-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-4014-8478","full_name":"Field, David"},{"first_name":"Spencer","last_name":"Barrett","full_name":"Barrett, Spencer"}],"month":"01","scopus_import":1,"date_created":"2018-12-11T11:50:48Z","citation":{"apa":"Teitel, Z., Pickup, M., Field, D., &#38; Barrett, S. (2016). The dynamics of resource allocation and costs of reproduction in a sexually dimorphic, wind-pollinated dioecious plant. <i>Plant Biology</i>. Wiley-Blackwell. <a href=\"https://doi.org/10.1111/plb.12336\">https://doi.org/10.1111/plb.12336</a>","ista":"Teitel Z, Pickup M, Field D, Barrett S. 2016. The dynamics of resource allocation and costs of reproduction in a sexually dimorphic, wind-pollinated dioecious plant. Plant Biology. 18(1), 98–103.","ama":"Teitel Z, Pickup M, Field D, Barrett S. The dynamics of resource allocation and costs of reproduction in a sexually dimorphic, wind-pollinated dioecious plant. <i>Plant Biology</i>. 2016;18(1):98-103. doi:<a href=\"https://doi.org/10.1111/plb.12336\">10.1111/plb.12336</a>","mla":"Teitel, Zachary, et al. “The Dynamics of Resource Allocation and Costs of Reproduction in a Sexually Dimorphic, Wind-Pollinated Dioecious Plant.” <i>Plant Biology</i>, vol. 18, no. 1, Wiley-Blackwell, 2016, pp. 98–103, doi:<a href=\"https://doi.org/10.1111/plb.12336\">10.1111/plb.12336</a>.","short":"Z. Teitel, M. Pickup, D. Field, S. Barrett, Plant Biology 18 (2016) 98–103.","ieee":"Z. Teitel, M. Pickup, D. Field, and S. Barrett, “The dynamics of resource allocation and costs of reproduction in a sexually dimorphic, wind-pollinated dioecious plant,” <i>Plant Biology</i>, vol. 18, no. 1. Wiley-Blackwell, pp. 98–103, 2016.","chicago":"Teitel, Zachary, Melinda Pickup, David Field, and Spencer Barrett. “The Dynamics of Resource Allocation and Costs of Reproduction in a Sexually Dimorphic, Wind-Pollinated Dioecious Plant.” <i>Plant Biology</i>. Wiley-Blackwell, 2016. <a href=\"https://doi.org/10.1111/plb.12336\">https://doi.org/10.1111/plb.12336</a>."},"year":"2016","type":"journal_article","volume":18,"doi":"10.1111/plb.12336","title":"The dynamics of resource allocation and costs of reproduction in a sexually dimorphic, wind-pollinated dioecious plant","department":[{"_id":"NiBa"}],"quality_controlled":"1","day":"01","publication_status":"published","date_updated":"2021-01-12T06:49:12Z","publisher":"Wiley-Blackwell"},{"main_file_link":[{"open_access":"1","url":"https://eprint.iacr.org/2016/662"}],"volume":9841,"type":"conference","department":[{"_id":"KrPi"}],"project":[{"name":"Provable Security for Physical Cryptography","_id":"258C570E-B435-11E9-9278-68D0E5697425","grant_number":"259668","call_identifier":"FP7"},{"name":"Teaching Old Crypto New Tricks","_id":"258AA5B2-B435-11E9-9278-68D0E5697425","grant_number":"682815","call_identifier":"H2020"}],"quality_controlled":"1","publication_status":"published","publisher":"Springer","abstract":[{"text":"At Crypto 2015 Fuchsbauer, Hanser and Slamanig (FHS) presented the first standard-model construction of efficient roundoptimal blind signatures that does not require complexity leveraging. It is conceptually simple and builds on the primitive of structure-preserving signatures on equivalence classes (SPS-EQ). FHS prove the unforgeability of their scheme assuming EUF-CMA security of the SPS-EQ scheme and hardness of a version of the DH inversion problem. Blindness under adversarially chosen keys is proven under an interactive variant of the DDH assumption. We propose a variant of their scheme whose blindness can be proven under a non-interactive assumption, namely a variant of the bilinear DDH assumption. We moreover prove its unforgeability assuming only unforgeability of the underlying SPS-EQ but no additional assumptions as needed for the FHS scheme.","lang":"eng"}],"status":"public","date_published":"2016-08-11T00:00:00Z","publist_id":"6109","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","intvolume":"      9841","oa_version":"Submitted Version","alternative_title":["LNCS"],"scopus_import":1,"date_created":"2018-12-11T11:50:49Z","related_material":{"record":[{"relation":"earlier_version","id":"1647","status":"public"}]},"conference":{"end_date":"2016-09-02","start_date":"2016-08-31","name":"SCN: Security and Cryptography for Networks","location":"Amalfi, Italy"},"year":"2016","ec_funded":1,"oa":1,"title":"Practical round-optimal blind signatures in the standard model from weaker assumptions","doi":"10.1007/978-3-319-44618-9_21","day":"11","date_updated":"2023-02-23T10:08:16Z","page":"391 - 408","language":[{"iso":"eng"}],"_id":"1225","month":"08","author":[{"first_name":"Georg","last_name":"Fuchsbauer","id":"46B4C3EE-F248-11E8-B48F-1D18A9856A87","full_name":"Fuchsbauer, Georg"},{"last_name":"Hanser","first_name":"Christian","full_name":"Hanser, Christian"},{"id":"4BD3F30E-F248-11E8-B48F-1D18A9856A87","first_name":"Chethan","last_name":"Kamath Hosdurg","full_name":"Kamath Hosdurg, Chethan"},{"last_name":"Slamanig","first_name":"Daniel","full_name":"Slamanig, Daniel"}],"citation":{"apa":"Fuchsbauer, G., Hanser, C., Kamath Hosdurg, C., &#38; Slamanig, D. (2016). Practical round-optimal blind signatures in the standard model from weaker assumptions (Vol. 9841, pp. 391–408). Presented at the SCN: Security and Cryptography for Networks, Amalfi, Italy: Springer. <a href=\"https://doi.org/10.1007/978-3-319-44618-9_21\">https://doi.org/10.1007/978-3-319-44618-9_21</a>","ista":"Fuchsbauer G, Hanser C, Kamath Hosdurg C, Slamanig D. 2016. Practical round-optimal blind signatures in the standard model from weaker assumptions. SCN: Security and Cryptography for Networks, LNCS, vol. 9841, 391–408.","ama":"Fuchsbauer G, Hanser C, Kamath Hosdurg C, Slamanig D. Practical round-optimal blind signatures in the standard model from weaker assumptions. In: Vol 9841. Springer; 2016:391-408. doi:<a href=\"https://doi.org/10.1007/978-3-319-44618-9_21\">10.1007/978-3-319-44618-9_21</a>","mla":"Fuchsbauer, Georg, et al. <i>Practical Round-Optimal Blind Signatures in the Standard Model from Weaker Assumptions</i>. Vol. 9841, Springer, 2016, pp. 391–408, doi:<a href=\"https://doi.org/10.1007/978-3-319-44618-9_21\">10.1007/978-3-319-44618-9_21</a>.","short":"G. Fuchsbauer, C. Hanser, C. Kamath Hosdurg, D. Slamanig, in:, Springer, 2016, pp. 391–408.","ieee":"G. Fuchsbauer, C. Hanser, C. Kamath Hosdurg, and D. Slamanig, “Practical round-optimal blind signatures in the standard model from weaker assumptions,” presented at the SCN: Security and Cryptography for Networks, Amalfi, Italy, 2016, vol. 9841, pp. 391–408.","chicago":"Fuchsbauer, Georg, Christian Hanser, Chethan Kamath Hosdurg, and Daniel Slamanig. “Practical Round-Optimal Blind Signatures in the Standard Model from Weaker Assumptions,” 9841:391–408. Springer, 2016. <a href=\"https://doi.org/10.1007/978-3-319-44618-9_21\">https://doi.org/10.1007/978-3-319-44618-9_21</a>."}},{"author":[{"first_name":"Karol","last_name":"Fiedorczuk","id":"5BFF67CE-02D1-11E9-B11A-A5A4D7DFFFD0","full_name":"Fiedorczuk, Karol"},{"id":"322DA418-F248-11E8-B48F-1D18A9856A87","last_name":"Letts","first_name":"James A","orcid":"0000-0002-9864-3586","full_name":"Letts, James A"},{"last_name":"Degliesposti","first_name":"Gianluca","full_name":"Degliesposti, Gianluca"},{"full_name":"Kaszuba, Karol","first_name":"Karol","last_name":"Kaszuba","id":"3FDF9472-F248-11E8-B48F-1D18A9856A87"},{"first_name":"Mark","last_name":"Skehel","full_name":"Skehel, Mark"},{"full_name":"Sazanov, Leonid A","orcid":"0000-0002-0977-7989","id":"338D39FE-F248-11E8-B48F-1D18A9856A87","first_name":"Leonid A","last_name":"Sazanov"}],"month":"10","citation":{"mla":"Fiedorczuk, Karol, et al. “Atomic Structure of the Entire Mammalian Mitochondrial Complex I.” <i>Nature</i>, vol. 538, no. 7625, Nature Publishing Group, 2016, pp. 406–10, doi:<a href=\"https://doi.org/10.1038/nature19794\">10.1038/nature19794</a>.","short":"K. Fiedorczuk, J.A. Letts, G. Degliesposti, K. Kaszuba, M. Skehel, L.A. Sazanov, Nature 538 (2016) 406–410.","ieee":"K. Fiedorczuk, J. A. Letts, G. Degliesposti, K. Kaszuba, M. Skehel, and L. A. Sazanov, “Atomic structure of the entire mammalian mitochondrial complex i,” <i>Nature</i>, vol. 538, no. 7625. Nature Publishing Group, pp. 406–410, 2016.","chicago":"Fiedorczuk, Karol, James A Letts, Gianluca Degliesposti, Karol Kaszuba, Mark Skehel, and Leonid A Sazanov. “Atomic Structure of the Entire Mammalian Mitochondrial Complex I.” <i>Nature</i>. Nature Publishing Group, 2016. <a href=\"https://doi.org/10.1038/nature19794\">https://doi.org/10.1038/nature19794</a>.","apa":"Fiedorczuk, K., Letts, J. A., Degliesposti, G., Kaszuba, K., Skehel, M., &#38; Sazanov, L. A. (2016). Atomic structure of the entire mammalian mitochondrial complex i. <i>Nature</i>. Nature Publishing Group. <a href=\"https://doi.org/10.1038/nature19794\">https://doi.org/10.1038/nature19794</a>","ista":"Fiedorczuk K, Letts JA, Degliesposti G, Kaszuba K, Skehel M, Sazanov LA. 2016. Atomic structure of the entire mammalian mitochondrial complex i. Nature. 538(7625), 406–410.","ama":"Fiedorczuk K, Letts JA, Degliesposti G, Kaszuba K, Skehel M, Sazanov LA. Atomic structure of the entire mammalian mitochondrial complex i. <i>Nature</i>. 2016;538(7625):406-410. doi:<a href=\"https://doi.org/10.1038/nature19794\">10.1038/nature19794</a>"},"article_type":"original","issue":"7625","page":"406 - 410","_id":"1226","language":[{"iso":"eng"}],"external_id":{"pmid":["27595392"]},"doi":"10.1038/nature19794","title":"Atomic structure of the entire mammalian mitochondrial complex i","date_updated":"2021-01-12T06:49:13Z","day":"20","year":"2016","ec_funded":1,"article_processing_charge":"No","oa":1,"oa_version":"Submitted Version","date_created":"2018-12-11T11:50:49Z","scopus_import":1,"publication":"Nature","publist_id":"6108","date_published":"2016-10-20T00:00:00Z","status":"public","abstract":[{"text":"Mitochondrial complex I (also known as NADH:ubiquinone oxidoreductase) contributes to cellular energy production by transferring electrons from NADH to ubiquinone coupled to proton translocation across the membrane. It is the largest protein assembly of the respiratory chain with a total mass of 970 kilodaltons. Here we present a nearly complete atomic structure of ovine (Ovis aries) mitochondrial complex I at 3.9 Å resolution, solved by cryo-electron microscopy with cross-linking and mass-spectrometry mapping experiments. All 14 conserved core subunits and 31 mitochondria-specific supernumerary subunits are resolved within the L-shaped molecule. The hydrophilic matrix arm comprises flavin mononucleotide and 8 iron-sulfur clusters involved in electron transfer, and the membrane arm contains 78 transmembrane helices, mostly contributed by antiporter-like subunits involved in proton translocation. Supernumerary subunits form an interlinked, stabilizing shell around the conserved core. Tightly bound lipids (including cardiolipins) further stabilize interactions between the hydrophobic subunits. Subunits with possible regulatory roles contain additional cofactors, NADPH and two phosphopantetheine molecules, which are shown to be involved in inter-subunit interactions. We observe two different conformations of the complex, which may be related to the conformationally driven coupling mechanism and to the active-deactive transition of the enzyme. Our structure provides insight into the mechanism, assembly, maturation and dysfunction of mitochondrial complex I, and allows detailed molecular analysis of disease-causing mutations.","lang":"eng"}],"intvolume":"       538","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","quality_controlled":"1","pmid":1,"project":[{"name":"Atomic-Resolution Structures of Mitochondrial Respiratory Chain Supercomplexes (FEBS)","_id":"2593EBD6-B435-11E9-9278-68D0E5697425"},{"grant_number":"701309","name":"Atomic-Resolution Structures of Mitochondrial Respiratory Chain Supercomplexes (H2020)","_id":"2590DB08-B435-11E9-9278-68D0E5697425","call_identifier":"H2020"}],"department":[{"_id":"LeSa"}],"publisher":"Nature Publishing Group","publication_status":"published","main_file_link":[{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5164932/","open_access":"1"}],"type":"journal_article","volume":538},{"ddc":["005"],"citation":{"ista":"Kong H, Bartocci E, Bogomolov S, Grosu R, Henzinger TA, Jiang Y, Schilling C. 2016. Discrete abstraction of multiaffine systems. HSB: Hybrid Systems Biology, LNCS, vol. 9957, 128–144.","apa":"Kong, H., Bartocci, E., Bogomolov, S., Grosu, R., Henzinger, T. A., Jiang, Y., &#38; Schilling, C. (2016). Discrete abstraction of multiaffine systems (Vol. 9957, pp. 128–144). Presented at the HSB: Hybrid Systems Biology, Grenoble, France: Springer. <a href=\"https://doi.org/10.1007/978-3-319-47151-8_9\">https://doi.org/10.1007/978-3-319-47151-8_9</a>","ama":"Kong H, Bartocci E, Bogomolov S, et al. Discrete abstraction of multiaffine systems. In: Vol 9957. Springer; 2016:128-144. doi:<a href=\"https://doi.org/10.1007/978-3-319-47151-8_9\">10.1007/978-3-319-47151-8_9</a>","mla":"Kong, Hui, et al. <i>Discrete Abstraction of Multiaffine Systems</i>. Vol. 9957, Springer, 2016, pp. 128–44, doi:<a href=\"https://doi.org/10.1007/978-3-319-47151-8_9\">10.1007/978-3-319-47151-8_9</a>.","short":"H. Kong, E. Bartocci, S. Bogomolov, R. Grosu, T.A. Henzinger, Y. Jiang, C. Schilling, in:, Springer, 2016, pp. 128–144.","chicago":"Kong, Hui, Ezio Bartocci, Sergiy Bogomolov, Radu Grosu, Thomas A Henzinger, Yu Jiang, and Christian Schilling. “Discrete Abstraction of Multiaffine Systems,” 9957:128–44. Springer, 2016. <a href=\"https://doi.org/10.1007/978-3-319-47151-8_9\">https://doi.org/10.1007/978-3-319-47151-8_9</a>.","ieee":"H. Kong <i>et al.</i>, “Discrete abstraction of multiaffine systems,” presented at the HSB: Hybrid Systems Biology, Grenoble, France, 2016, vol. 9957, pp. 128–144."},"author":[{"id":"3BDE25AA-F248-11E8-B48F-1D18A9856A87","first_name":"Hui","last_name":"Kong","orcid":"0000-0002-3066-6941","full_name":"Kong, Hui"},{"first_name":"Ezio","last_name":"Bartocci","full_name":"Bartocci, Ezio"},{"id":"369D9A44-F248-11E8-B48F-1D18A9856A87","last_name":"Bogomolov","first_name":"Sergiy","full_name":"Bogomolov, Sergiy","orcid":"0000-0002-0686-0365"},{"first_name":"Radu","last_name":"Grosu","full_name":"Grosu, Radu"},{"id":"40876CD8-F248-11E8-B48F-1D18A9856A87","first_name":"Thomas A","last_name":"Henzinger","orcid":"0000−0002−2985−7724","full_name":"Henzinger, Thomas A"},{"full_name":"Jiang, Yu","last_name":"Jiang","first_name":"Yu"},{"orcid":"0000-0003-3658-1065","full_name":"Schilling, Christian","id":"3A2F4DCE-F248-11E8-B48F-1D18A9856A87","last_name":"Schilling","first_name":"Christian"}],"file":[{"file_id":"4840","file_size":683955,"date_created":"2018-12-12T10:10:49Z","date_updated":"2020-07-14T12:44:39Z","access_level":"open_access","content_type":"application/pdf","creator":"system","checksum":"994e164b558c47bacf8dc066dd27c8fc","relation":"main_file","file_name":"IST-2017-781-v1+1_main.pdf"}],"month":"09","file_date_updated":"2020-07-14T12:44:39Z","language":[{"iso":"eng"}],"_id":"1227","pubrep_id":"781","acknowledgement":"This research was supported in part by the Austrian Science Fund (FWF) under grants S11402-N23, S11405-N23 and S11412-N23 (RiSE/SHiNE) and Z211-N23 (Wittgenstein Award).","page":"128 - 144","day":"25","date_updated":"2021-01-12T06:49:13Z","doi":"10.1007/978-3-319-47151-8_9","title":"Discrete abstraction of multiaffine systems","oa":1,"conference":{"location":"Grenoble, France","name":"HSB: Hybrid Systems Biology","start_date":"2016-10-20","end_date":"2016-10-21"},"has_accepted_license":"1","year":"2016","scopus_import":1,"alternative_title":["LNCS"],"date_created":"2018-12-11T11:50:49Z","oa_version":"Submitted Version","user_id":"3E5EF7F0-F248-11E8-B48F-1D18A9856A87","intvolume":"      9957","abstract":[{"lang":"eng","text":"Many biological systems can be modeled as multiaffine hybrid systems. Due to the nonlinearity of multiaffine systems, it is difficult to verify their properties of interest directly. A common strategy to tackle this problem is to construct and analyze a discrete overapproximation of the original system. However, the conservativeness of a discrete abstraction significantly determines the level of confidence we can have in the properties of the original system. In this paper, in order to reduce the conservativeness of a discrete abstraction, we propose a new method based on a sufficient and necessary decision condition for computing discrete transitions between states in the abstract system. We assume the state space partition of a multiaffine system to be based on a set of multivariate polynomials. Hence, a rectangular partition defined in terms of polynomials of the form (xi − c) is just a simple case of multivariate polynomial partition, and the new decision condition applies naturally. We analyze and demonstrate the improvement of our method over the existing methods using some examples."}],"publist_id":"6107","status":"public","date_published":"2016-09-25T00:00:00Z","publication_status":"published","publisher":"Springer","department":[{"_id":"ToHe"}],"quality_controlled":"1","project":[{"call_identifier":"FWF","_id":"25F42A32-B435-11E9-9278-68D0E5697425","name":"The Wittgenstein Prize","grant_number":"Z211"},{"call_identifier":"FWF","grant_number":"S 11407_N23","_id":"25832EC2-B435-11E9-9278-68D0E5697425","name":"Rigorous Systems Engineering"}],"type":"conference","volume":9957},{"pubrep_id":"765","_id":"1229","language":[{"iso":"eng"}],"acknowledgement":"Research  supported  by  the  European  Research  Council,  ERC  starting  grant (259668-PSPC) and ERC consolidator grant (682815 - TOCNeT).","page":"285 - 303","ddc":["005","600"],"citation":{"mla":"Abusalah, Hamza M., et al. <i>Offline Witness Encryption</i>. Vol. 9696, Springer, 2016, pp. 285–303, doi:<a href=\"https://doi.org/10.1007/978-3-319-39555-5_16\">10.1007/978-3-319-39555-5_16</a>.","short":"H.M. Abusalah, G. Fuchsbauer, K.Z. Pietrzak, in:, Springer, 2016, pp. 285–303.","chicago":"Abusalah, Hamza M, Georg Fuchsbauer, and Krzysztof Z Pietrzak. “Offline Witness Encryption,” 9696:285–303. Springer, 2016. <a href=\"https://doi.org/10.1007/978-3-319-39555-5_16\">https://doi.org/10.1007/978-3-319-39555-5_16</a>.","ieee":"H. M. Abusalah, G. Fuchsbauer, and K. Z. Pietrzak, “Offline witness encryption,” presented at the ACNS: Applied Cryptography and Network Security, Guildford, UK, 2016, vol. 9696, pp. 285–303.","ista":"Abusalah HM, Fuchsbauer G, Pietrzak KZ. 2016. Offline witness encryption. ACNS: Applied Cryptography and Network Security, LNCS, vol. 9696, 285–303.","apa":"Abusalah, H. M., Fuchsbauer, G., &#38; Pietrzak, K. Z. (2016). Offline witness encryption (Vol. 9696, pp. 285–303). Presented at the ACNS: Applied Cryptography and Network Security, Guildford, UK: Springer. <a href=\"https://doi.org/10.1007/978-3-319-39555-5_16\">https://doi.org/10.1007/978-3-319-39555-5_16</a>","ama":"Abusalah HM, Fuchsbauer G, Pietrzak KZ. Offline witness encryption. In: Vol 9696. Springer; 2016:285-303. doi:<a href=\"https://doi.org/10.1007/978-3-319-39555-5_16\">10.1007/978-3-319-39555-5_16</a>"},"file":[{"file_id":"5273","file_size":515000,"date_created":"2018-12-12T10:17:20Z","date_updated":"2020-07-14T12:44:39Z","access_level":"open_access","content_type":"application/pdf","creator":"system","checksum":"34fa9ce681da845a1ba945ba3dc57867","relation":"main_file","file_name":"IST-2017-765-v1+1_838.pdf"}],"author":[{"full_name":"Abusalah, Hamza M","id":"40297222-F248-11E8-B48F-1D18A9856A87","last_name":"Abusalah","first_name":"Hamza M"},{"id":"46B4C3EE-F248-11E8-B48F-1D18A9856A87","last_name":"Fuchsbauer","first_name":"Georg","full_name":"Fuchsbauer, Georg"},{"id":"3E04A7AA-F248-11E8-B48F-1D18A9856A87","last_name":"Pietrzak","first_name":"Krzysztof Z","full_name":"Pietrzak, Krzysztof Z","orcid":"0000-0002-9139-1654"}],"file_date_updated":"2020-07-14T12:44:39Z","month":"06","oa":1,"conference":{"end_date":"2016-06-22","start_date":"2016-06-19","name":"ACNS: Applied Cryptography and Network Security","location":"Guildford, UK"},"has_accepted_license":"1","related_material":{"record":[{"status":"public","relation":"dissertation_contains","id":"83"}]},"ec_funded":1,"year":"2016","day":"09","date_updated":"2023-09-07T12:30:22Z","doi":"10.1007/978-3-319-39555-5_16","title":"Offline witness encryption","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","intvolume":"      9696","abstract":[{"text":"Witness encryption (WE) was introduced by Garg et al. [GGSW13]. A WE scheme is defined for some NP language L and lets a sender encrypt messages relative to instances x. A ciphertext for x can be decrypted using w witnessing x ∈ L, but hides the message if x ∈ L. Garg et al. construct WE from multilinear maps and give another construction [GGH+13b] using indistinguishability obfuscation (iO) for circuits. Due to the reliance on such heavy tools, WE can cur- rently hardly be implemented on powerful hardware and will unlikely be realizable on constrained devices like smart cards any time soon. We construct a WE scheme where encryption is done by simply computing a Naor-Yung ciphertext (two CPA encryptions and a NIZK proof). To achieve this, our scheme has a setup phase, which outputs public parameters containing an obfuscated circuit (only required for decryption), two encryption keys and a common reference string (used for encryption). This setup need only be run once, and the parame- ters can be used for arbitrary many encryptions. Our scheme can also be turned into a functional WE scheme, where a message is encrypted w.r.t. a statement and a function f, and decryption with a witness w yields f (m, w). Our construction is inspired by the functional encryption scheme by Garg et al. and we prove (selective) security assuming iO and statistically simulation-sound NIZK. We give a construction of the latter in bilinear groups and combining it with ElGamal encryption, our ciphertexts are of size 1.3 kB at a 128-bit security level and can be computed on a smart card.","lang":"eng"}],"publist_id":"6105","status":"public","date_published":"2016-06-09T00:00:00Z","scopus_import":1,"alternative_title":["LNCS"],"date_created":"2018-12-11T11:50:50Z","oa_version":"Submitted Version","type":"conference","volume":9696,"publication_status":"published","publisher":"Springer","department":[{"_id":"KrPi"}],"quality_controlled":"1","project":[{"name":"Provable Security for Physical Cryptography","_id":"258C570E-B435-11E9-9278-68D0E5697425","grant_number":"259668","call_identifier":"FP7"},{"call_identifier":"H2020","name":"Teaching Old Crypto New Tricks","_id":"258AA5B2-B435-11E9-9278-68D0E5697425","grant_number":"682815"}]},{"related_material":{"record":[{"relation":"dissertation_contains","id":"1155","status":"public"}]},"conference":{"name":"VMCAI: Verification, Model Checking and Abstract Interpretation","location":"St. Petersburg, FL, USA","end_date":"2016-01-19","start_date":"2016-01-17"},"year":"2016","ec_funded":1,"oa":1,"title":"Abstraction-driven concolic testing","doi":"10.1007/978-3-662-49122-5_16","day":"01","date_updated":"2023-09-07T11:58:33Z","page":"328 - 347","acknowledgement":"We thank Andrey Kupriyanov for feedback on the manuscript,\r\nand Michael Tautschnig for help with preparing the experiments. This research was supported in part by the European Research Council (ERC) under grant 267989 (QUAREM) and by the Austrian Science Fund (FWF) under grants S11402-N23 (RiSE) and Z211-N23 (Wittgenstein Award).","language":[{"iso":"eng"}],"_id":"1230","month":"01","author":[{"id":"49351290-F248-11E8-B48F-1D18A9856A87","last_name":"Daca","first_name":"Przemyslaw","full_name":"Daca, Przemyslaw"},{"id":"335E5684-F248-11E8-B48F-1D18A9856A87","last_name":"Gupta","first_name":"Ashutosh","full_name":"Gupta, Ashutosh"},{"last_name":"Henzinger","first_name":"Thomas A","id":"40876CD8-F248-11E8-B48F-1D18A9856A87","orcid":"0000−0002−2985−7724","full_name":"Henzinger, Thomas A"}],"citation":{"ista":"Daca P, Gupta A, Henzinger TA. 2016. Abstraction-driven concolic testing. VMCAI: Verification, Model Checking and Abstract Interpretation, LNCS, vol. 9583, 328–347.","apa":"Daca, P., Gupta, A., &#38; Henzinger, T. A. (2016). Abstraction-driven concolic testing (Vol. 9583, pp. 328–347). Presented at the VMCAI: Verification, Model Checking and Abstract Interpretation, St. Petersburg, FL, USA: Springer. <a href=\"https://doi.org/10.1007/978-3-662-49122-5_16\">https://doi.org/10.1007/978-3-662-49122-5_16</a>","ama":"Daca P, Gupta A, Henzinger TA. Abstraction-driven concolic testing. In: Vol 9583. Springer; 2016:328-347. doi:<a href=\"https://doi.org/10.1007/978-3-662-49122-5_16\">10.1007/978-3-662-49122-5_16</a>","short":"P. Daca, A. Gupta, T.A. Henzinger, in:, Springer, 2016, pp. 328–347.","mla":"Daca, Przemyslaw, et al. <i>Abstraction-Driven Concolic Testing</i>. Vol. 9583, Springer, 2016, pp. 328–47, doi:<a href=\"https://doi.org/10.1007/978-3-662-49122-5_16\">10.1007/978-3-662-49122-5_16</a>.","chicago":"Daca, Przemyslaw, Ashutosh Gupta, and Thomas A Henzinger. “Abstraction-Driven Concolic Testing,” 9583:328–47. Springer, 2016. <a href=\"https://doi.org/10.1007/978-3-662-49122-5_16\">https://doi.org/10.1007/978-3-662-49122-5_16</a>.","ieee":"P. Daca, A. Gupta, and T. A. Henzinger, “Abstraction-driven concolic testing,” presented at the VMCAI: Verification, Model Checking and Abstract Interpretation, St. Petersburg, FL, USA, 2016, vol. 9583, pp. 328–347."},"main_file_link":[{"url":"https://arxiv.org/abs/1511.02615","open_access":"1"}],"volume":9583,"type":"conference","department":[{"_id":"ToHe"}],"project":[{"grant_number":"267989","_id":"25EE3708-B435-11E9-9278-68D0E5697425","name":"Quantitative Reactive Modeling","call_identifier":"FP7"},{"grant_number":"Z211","name":"The Wittgenstein Prize","_id":"25F42A32-B435-11E9-9278-68D0E5697425","call_identifier":"FWF"},{"call_identifier":"FWF","grant_number":"S 11407_N23","name":"Rigorous Systems Engineering","_id":"25832EC2-B435-11E9-9278-68D0E5697425"}],"quality_controlled":"1","publication_status":"published","publisher":"Springer","abstract":[{"lang":"eng","text":"Concolic testing is a promising method for generating test suites for large programs. However, it suffers from the path-explosion problem and often fails to find tests that cover difficult-to-reach parts of programs. In contrast, model checkers based on counterexample-guided abstraction refinement explore programs exhaustively, while failing to scale on large programs with precision. In this paper, we present a novel method that iteratively combines concolic testing and model checking to find a test suite for a given coverage criterion. If concolic testing fails to cover some test goals, then the model checker refines its program abstraction to prove more paths infeasible, which reduces the search space for concolic testing. We have implemented our method on top of the concolictesting tool Crest and the model checker CpaChecker. We evaluated our tool on a collection of programs and a category of SvComp benchmarks. In our experiments, we observed an improvement in branch coverage compared to Crest from 48% to 63% in the best case, and from 66% to 71% on average."}],"status":"public","date_published":"2016-01-01T00:00:00Z","publist_id":"6104","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","intvolume":"      9583","oa_version":"Preprint","alternative_title":["LNCS"],"scopus_import":1,"date_created":"2018-12-11T11:50:50Z"},{"citation":{"mla":"Alwen, Joel F., et al. <i>On the Complexity of Scrypt and Proofs of Space in the Parallel Random Oracle Model</i>. Vol. 9666, Springer, 2016, pp. 358–87, doi:<a href=\"https://doi.org/10.1007/978-3-662-49896-5_13\">10.1007/978-3-662-49896-5_13</a>.","short":"J.F. Alwen, B. Chen, C. Kamath Hosdurg, V. Kolmogorov, K.Z. Pietrzak, S. Tessaro, in:, Springer, 2016, pp. 358–387.","ieee":"J. F. Alwen, B. Chen, C. Kamath Hosdurg, V. Kolmogorov, K. Z. Pietrzak, and S. Tessaro, “On the complexity of scrypt and proofs of space in the parallel random oracle model,” presented at the EUROCRYPT: Theory and Applications of Cryptographic Techniques, Vienna, Austria, 2016, vol. 9666, pp. 358–387.","chicago":"Alwen, Joel F, Binyi Chen, Chethan Kamath Hosdurg, Vladimir Kolmogorov, Krzysztof Z Pietrzak, and Stefano Tessaro. “On the Complexity of Scrypt and Proofs of Space in the Parallel Random Oracle Model,” 9666:358–87. Springer, 2016. <a href=\"https://doi.org/10.1007/978-3-662-49896-5_13\">https://doi.org/10.1007/978-3-662-49896-5_13</a>.","apa":"Alwen, J. F., Chen, B., Kamath Hosdurg, C., Kolmogorov, V., Pietrzak, K. Z., &#38; Tessaro, S. (2016). On the complexity of scrypt and proofs of space in the parallel random oracle model (Vol. 9666, pp. 358–387). Presented at the EUROCRYPT: Theory and Applications of Cryptographic Techniques, Vienna, Austria: Springer. <a href=\"https://doi.org/10.1007/978-3-662-49896-5_13\">https://doi.org/10.1007/978-3-662-49896-5_13</a>","ista":"Alwen JF, Chen B, Kamath Hosdurg C, Kolmogorov V, Pietrzak KZ, Tessaro S. 2016. On the complexity of scrypt and proofs of space in the parallel random oracle model. EUROCRYPT: Theory and Applications of Cryptographic Techniques, LNCS, vol. 9666, 358–387.","ama":"Alwen JF, Chen B, Kamath Hosdurg C, Kolmogorov V, Pietrzak KZ, Tessaro S. On the complexity of scrypt and proofs of space in the parallel random oracle model. In: Vol 9666. Springer; 2016:358-387. doi:<a href=\"https://doi.org/10.1007/978-3-662-49896-5_13\">10.1007/978-3-662-49896-5_13</a>"},"author":[{"full_name":"Alwen, Joel F","last_name":"Alwen","first_name":"Joel F","id":"2A8DFA8C-F248-11E8-B48F-1D18A9856A87"},{"last_name":"Chen","first_name":"Binyi","full_name":"Chen, Binyi"},{"full_name":"Kamath Hosdurg, Chethan","first_name":"Chethan","last_name":"Kamath Hosdurg","id":"4BD3F30E-F248-11E8-B48F-1D18A9856A87"},{"id":"3D50B0BA-F248-11E8-B48F-1D18A9856A87","first_name":"Vladimir","last_name":"Kolmogorov","full_name":"Kolmogorov, Vladimir"},{"id":"3E04A7AA-F248-11E8-B48F-1D18A9856A87","last_name":"Pietrzak","first_name":"Krzysztof Z","full_name":"Pietrzak, Krzysztof Z","orcid":"0000-0002-9139-1654"},{"full_name":"Tessaro, Stefano","last_name":"Tessaro","first_name":"Stefano"}],"month":"04","language":[{"iso":"eng"}],"_id":"1231","acknowledgement":"Joël Alwen, Chethan Kamath, and Krzysztof Pietrzak’s research is partially supported by an ERC starting grant (259668-PSPC). Vladimir Kolmogorov is partially supported by an ERC consolidator grant (616160-DOICV). Binyi Chen was partially supported by NSF grants CNS-1423566 and CNS-1514526, and a gift from the Gareatis Foundation. Stefano Tessaro was partially supported by NSF grants CNS-1423566, CNS-1528178, a Hellman Fellowship, and the Glen and Susanne Culler Chair.\r\n\r\nThis work was done in part while the authors were visiting the Simons Institute for the Theory of Computing, supported by the Simons Foundation and by the DIMACS/Simons Collaboration in Cryptography through NSF grant CNS-1523467.","page":"358 - 387","day":"28","date_updated":"2021-01-12T06:49:15Z","doi":"10.1007/978-3-662-49896-5_13","title":"On the complexity of scrypt and proofs of space in the parallel random oracle model","oa":1,"conference":{"name":"EUROCRYPT: Theory and Applications of Cryptographic Techniques","location":"Vienna, Austria","end_date":"2016-05-12","start_date":"2016-05-08"},"ec_funded":1,"year":"2016","scopus_import":1,"alternative_title":["LNCS"],"date_created":"2018-12-11T11:50:51Z","oa_version":"Submitted Version","user_id":"3E5EF7F0-F248-11E8-B48F-1D18A9856A87","intvolume":"      9666","abstract":[{"text":"We study the time-and memory-complexities of the problem of computing labels of (multiple) randomly selected challenge-nodes in a directed acyclic graph. The w-bit label of a node is the hash of the labels of its parents, and the hash function is modeled as a random oracle. Specific instances of this problem underlie both proofs of space [Dziembowski et al. CRYPTO’15] as well as popular memory-hard functions like scrypt. As our main tool, we introduce the new notion of a probabilistic parallel entangled pebbling game, a new type of combinatorial pebbling game on a graph, which is closely related to the labeling game on the same graph. As a first application of our framework, we prove that for scrypt, when the underlying hash function is invoked n times, the cumulative memory complexity (CMC) (a notion recently introduced by Alwen and Serbinenko (STOC’15) to capture amortized memory-hardness for parallel adversaries) is at least Ω(w · (n/ log(n))2). This bound holds for adversaries that can store many natural functions of the labels (e.g., linear combinations), but still not arbitrary functions thereof. We then introduce and study a combinatorial quantity, and show how a sufficiently small upper bound on it (which we conjecture) extends our CMC bound for scrypt to hold against arbitrary adversaries. We also show that such an upper bound solves the main open problem for proofs-of-space protocols: namely, establishing that the time complexity of computing the label of a random node in a graph on n nodes (given an initial kw-bit state) reduces tightly to the time complexity for black pebbling on the same graph (given an initial k-node pebbling).","lang":"eng"}],"publist_id":"6103","date_published":"2016-04-28T00:00:00Z","status":"public","publication_status":"published","publisher":"Springer","department":[{"_id":"KrPi"},{"_id":"VlKo"}],"quality_controlled":"1","project":[{"call_identifier":"FP7","grant_number":"259668","name":"Provable Security for Physical Cryptography","_id":"258C570E-B435-11E9-9278-68D0E5697425"},{"_id":"25FBA906-B435-11E9-9278-68D0E5697425","name":"Discrete Optimization in Computer Vision: Theory and Practice","grant_number":"616160","call_identifier":"FP7"}],"type":"conference","volume":9666,"main_file_link":[{"open_access":"1","url":"https://eprint.iacr.org/2016/100"}]},{"type":"journal_article","volume":537,"year":"2016","day":"29","publication_status":"published","date_updated":"2021-01-12T06:49:16Z","publisher":"Nature Publishing Group","doi":"10.1038/nature19774","title":"The architecture of respiratory supercomplexes","department":[{"_id":"LeSa"}],"quality_controlled":"1","project":[{"_id":"2593EBD6-B435-11E9-9278-68D0E5697425","name":"Atomic-Resolution Structures of Mitochondrial Respiratory Chain Supercomplexes (FEBS)"}],"user_id":"3E5EF7F0-F248-11E8-B48F-1D18A9856A87","_id":"1232","intvolume":"       537","language":[{"iso":"eng"}],"acknowledgement":"We thank the MRC LMB Cambridge for the use of the Titan Krios microscope. Data processing was performed using the IST high-performance computer cluster. J.A.L. holds a long-term fellowship from FEBS. K.F. is partially funded by a MRC UK PhD fellowship.","page":"644 - 648","abstract":[{"text":"Mitochondrial electron transport chain complexes are organized into supercomplexes responsible for carrying out cellular respiration. Here we present three architectures of mammalian (ovine) supercomplexes determined by cryo-electron microscopy. We identify two distinct arrangements of supercomplex CICIII 2 CIV (the respirasome) - a major 'tight' form and a minor 'loose' form (resolved at the resolution of 5.8 Å and 6.7 Å, respectively), which may represent different stages in supercomplex assembly or disassembly. We have also determined an architecture of supercomplex CICIII 2 at 7.8 Å resolution. All observed density can be attributed to the known 80 subunits of the individual complexes, including 132 transmembrane helices. The individual complexes form tight interactions that vary between the architectures, with complex IV subunit COX7a switching contact from complex III to complex I. The arrangement of active sites within the supercomplex may help control reactive oxygen species production. To our knowledge, these are the first complete architectures of the dominant, physiologically relevant state of the electron transport chain.","lang":"eng"}],"publist_id":"6102","publication":"Nature","issue":"7622","status":"public","date_published":"2016-09-29T00:00:00Z","scopus_import":1,"citation":{"apa":"Letts, J. A., Fiedorczuk, K., &#38; Sazanov, L. A. (2016). The architecture of respiratory supercomplexes. <i>Nature</i>. Nature Publishing Group. <a href=\"https://doi.org/10.1038/nature19774\">https://doi.org/10.1038/nature19774</a>","ista":"Letts JA, Fiedorczuk K, Sazanov LA. 2016. The architecture of respiratory supercomplexes. Nature. 537(7622), 644–648.","ama":"Letts JA, Fiedorczuk K, Sazanov LA. The architecture of respiratory supercomplexes. <i>Nature</i>. 2016;537(7622):644-648. doi:<a href=\"https://doi.org/10.1038/nature19774\">10.1038/nature19774</a>","short":"J.A. Letts, K. Fiedorczuk, L.A. Sazanov, Nature 537 (2016) 644–648.","mla":"Letts, James A., et al. “The Architecture of Respiratory Supercomplexes.” <i>Nature</i>, vol. 537, no. 7622, Nature Publishing Group, 2016, pp. 644–48, doi:<a href=\"https://doi.org/10.1038/nature19774\">10.1038/nature19774</a>.","ieee":"J. A. Letts, K. Fiedorczuk, and L. A. Sazanov, “The architecture of respiratory supercomplexes,” <i>Nature</i>, vol. 537, no. 7622. Nature Publishing Group, pp. 644–648, 2016.","chicago":"Letts, James A, Karol Fiedorczuk, and Leonid A Sazanov. “The Architecture of Respiratory Supercomplexes.” <i>Nature</i>. Nature Publishing Group, 2016. <a href=\"https://doi.org/10.1038/nature19774\">https://doi.org/10.1038/nature19774</a>."},"date_created":"2018-12-11T11:50:51Z","oa_version":"None","author":[{"first_name":"James A","last_name":"Letts","id":"322DA418-F248-11E8-B48F-1D18A9856A87","full_name":"Letts, James A","orcid":"0000-0002-9864-3586"},{"last_name":"Fiedorczuk","first_name":"Karol","id":"5BFF67CE-02D1-11E9-B11A-A5A4D7DFFFD0","full_name":"Fiedorczuk, Karol"},{"orcid":"0000-0002-0977-7989","full_name":"Sazanov, Leonid A","first_name":"Leonid A","last_name":"Sazanov","id":"338D39FE-F248-11E8-B48F-1D18A9856A87"}],"month":"09"}]