[{"intvolume":"       375","publisher":"The Royal Society","type":"journal_article","language":[{"iso":"eng"}],"quality_controlled":"1","isi":1,"user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","department":[{"_id":"NiBa"}],"scopus_import":"1","date_created":"2020-07-13T03:41:39Z","date_published":"2020-07-12T00:00:00Z","external_id":{"pmid":["32654647"],"isi":["000552662100002"]},"date_updated":"2023-08-22T07:53:52Z","publication":"Philosophical Transactions of the Royal Society. Series B: Biological Sciences","article_type":"letter_note","article_number":"20190530","year":"2020","volume":375,"article_processing_charge":"No","pmid":1,"month":"07","day":"12","citation":{"chicago":"Barton, Nicholas H. “On the Completion of Speciation.” <i>Philosophical Transactions of the Royal Society. Series B: Biological Sciences</i>. The Royal Society, 2020. <a href=\"https://doi.org/10.1098/rstb.2019.0530\">https://doi.org/10.1098/rstb.2019.0530</a>.","mla":"Barton, Nicholas H. “On the Completion of Speciation.” <i>Philosophical Transactions of the Royal Society. Series B: Biological Sciences</i>, vol. 375, no. 1806, 20190530, The Royal Society, 2020, doi:<a href=\"https://doi.org/10.1098/rstb.2019.0530\">10.1098/rstb.2019.0530</a>.","ama":"Barton NH. On the completion of speciation. <i>Philosophical Transactions of the Royal Society Series B: Biological Sciences</i>. 2020;375(1806). doi:<a href=\"https://doi.org/10.1098/rstb.2019.0530\">10.1098/rstb.2019.0530</a>","ista":"Barton NH. 2020. On the completion of speciation. Philosophical Transactions of the Royal Society. Series B: Biological Sciences. 375(1806), 20190530.","short":"N.H. Barton, Philosophical Transactions of the Royal Society. Series B: Biological Sciences 375 (2020).","ieee":"N. H. Barton, “On the completion of speciation,” <i>Philosophical Transactions of the Royal Society. Series B: Biological Sciences</i>, vol. 375, no. 1806. The Royal Society, 2020.","apa":"Barton, N. H. (2020). On the completion of speciation. <i>Philosophical Transactions of the Royal Society. Series B: Biological Sciences</i>. The Royal Society. <a href=\"https://doi.org/10.1098/rstb.2019.0530\">https://doi.org/10.1098/rstb.2019.0530</a>"},"oa_version":"None","publication_identifier":{"eissn":["1471-2970"],"issn":["0962-8436"]},"publication_status":"published","status":"public","_id":"8112","author":[{"orcid":"0000-0002-8548-5240","id":"4880FE40-F248-11E8-B48F-1D18A9856A87","first_name":"Nicholas H","full_name":"Barton, Nicholas H","last_name":"Barton"}],"title":"On the completion of speciation","doi":"10.1098/rstb.2019.0530","issue":"1806"},{"status":"public","publication_status":"published","publication_identifier":{"eissn":["1529-2401"]},"doi":"10.1523/JNEUROSCI.0276-20.2020","issue":"50","abstract":[{"text":"Cortical areas comprise multiple types of inhibitory interneurons with stereotypical connectivity motifs, but their combined effect on postsynaptic dynamics has been largely unexplored. Here, we analyse the response of a single postsynaptic model neuron receiving tuned excitatory connections alongside inhibition from two plastic populations. Depending on the inhibitory plasticity rule, synapses remain unspecific (flat), become anti-correlated to, or mirror excitatory synapses. Crucially, the neuron’s receptive field, i.e., its response to presynaptic stimuli, depends on the modulatory state of inhibition. When both inhibitory populations are active, inhibition balances excitation, resulting in uncorrelated postsynaptic responses regardless of the inhibitory tuning profiles. Modulating the activity of a given inhibitory population produces strong correlations to either preferred or non-preferred inputs, in line with recent experimental findings showing dramatic context-dependent changes of neurons’ receptive fields. We thus confirm that a neuron’s receptive field doesn’t follow directly from the weight profiles of its presynaptic afferents.","lang":"eng"}],"_id":"8126","author":[{"orcid":"0000-0001-7184-7311","first_name":"Everton J.","full_name":"Agnes, Everton J.","last_name":"Agnes"},{"first_name":"Andrea I.","last_name":"Luppi","full_name":"Luppi, Andrea I."},{"first_name":"Tim P","id":"CB6FF8D2-008F-11EA-8E08-2637E6697425","last_name":"Vogels","full_name":"Vogels, Tim P","orcid":"0000-0003-3295-6181"}],"title":"Complementary inhibitory weight profiles emerge from plasticity and allow attentional switching of receptive fields","volume":40,"article_processing_charge":"No","has_accepted_license":"1","file":[{"date_created":"2020-12-28T08:31:47Z","file_id":"8977","file_size":2750920,"relation":"main_file","creator":"dernst","file_name":"2020_JourNeuroscience_Agnes.pdf","date_updated":"2020-12-28T08:31:47Z","success":1,"checksum":"7977e4dd6b89357d1a5cc88babac56da","content_type":"application/pdf","access_level":"open_access"}],"tmp":{"name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","image":"/images/cc_by.png","short":"CC BY (4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode"},"oa_version":"Published Version","license":"https://creativecommons.org/licenses/by/4.0/","file_date_updated":"2020-12-28T08:31:47Z","pmid":1,"month":"12","ddc":["570"],"day":"09","citation":{"ista":"Agnes EJ, Luppi AI, Vogels TP. 2020. Complementary inhibitory weight profiles emerge from plasticity and allow attentional switching of receptive fields. The Journal of Neuroscience. 40(50), 9634–9649.","ama":"Agnes EJ, Luppi AI, Vogels TP. Complementary inhibitory weight profiles emerge from plasticity and allow attentional switching of receptive fields. <i>The Journal of Neuroscience</i>. 2020;40(50):9634-9649. doi:<a href=\"https://doi.org/10.1523/JNEUROSCI.0276-20.2020\">10.1523/JNEUROSCI.0276-20.2020</a>","short":"E.J. Agnes, A.I. Luppi, T.P. Vogels, The Journal of Neuroscience 40 (2020) 9634–9649.","apa":"Agnes, E. J., Luppi, A. I., &#38; Vogels, T. P. (2020). Complementary inhibitory weight profiles emerge from plasticity and allow attentional switching of receptive fields. <i>The Journal of Neuroscience</i>. Society for Neuroscience. <a href=\"https://doi.org/10.1523/JNEUROSCI.0276-20.2020\">https://doi.org/10.1523/JNEUROSCI.0276-20.2020</a>","ieee":"E. J. Agnes, A. I. Luppi, and T. P. Vogels, “Complementary inhibitory weight profiles emerge from plasticity and allow attentional switching of receptive fields,” <i>The Journal of Neuroscience</i>, vol. 40, no. 50. Society for Neuroscience, pp. 9634–9649, 2020.","mla":"Agnes, Everton J., et al. “Complementary Inhibitory Weight Profiles Emerge from Plasticity and Allow Attentional Switching of Receptive Fields.” <i>The Journal of Neuroscience</i>, vol. 40, no. 50, Society for Neuroscience, 2020, pp. 9634–49, doi:<a href=\"https://doi.org/10.1523/JNEUROSCI.0276-20.2020\">10.1523/JNEUROSCI.0276-20.2020</a>.","chicago":"Agnes, Everton J., Andrea I. Luppi, and Tim P Vogels. “Complementary Inhibitory Weight Profiles Emerge from Plasticity and Allow Attentional Switching of Receptive Fields.” <i>The Journal of Neuroscience</i>. Society for Neuroscience, 2020. <a href=\"https://doi.org/10.1523/JNEUROSCI.0276-20.2020\">https://doi.org/10.1523/JNEUROSCI.0276-20.2020</a>."},"article_type":"original","page":"9634-9649","date_updated":"2023-08-22T07:54:26Z","publication":"The Journal of Neuroscience","year":"2020","oa":1,"quality_controlled":"1","type":"journal_article","language":[{"iso":"eng"}],"isi":1,"intvolume":"        40","publisher":"Society for Neuroscience","scopus_import":"1","date_created":"2020-07-16T12:25:04Z","date_published":"2020-12-09T00:00:00Z","external_id":{"isi":["000606706400009"],"pmid":["33168622"]},"user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","department":[{"_id":"TiVo"}]},{"year":"2020","oa":1,"article_type":"original","article_number":"e56261","publication":"eLife","date_updated":"2023-08-22T07:54:52Z","date_published":"2020-09-17T00:00:00Z","external_id":{"isi":["000584989400001"],"pmid":["32940606"]},"scopus_import":"1","date_created":"2020-07-16T12:26:04Z","department":[{"_id":"TiVo"}],"user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","isi":1,"type":"journal_article","language":[{"iso":"eng"}],"quality_controlled":"1","intvolume":"         9","publisher":"eLife Sciences Publications","abstract":[{"text":"Mechanistic modeling in neuroscience aims to explain observed phenomena in terms of underlying causes. However, determining which model parameters agree with complex and stochastic neural data presents a significant challenge. We address this challenge with a machine learning tool which uses deep neural density estimators—trained using model simulations—to carry out Bayesian inference and retrieve the full space of parameters compatible with raw data or selected data features. Our method is scalable in parameters and data features and can rapidly analyze new data after initial training. We demonstrate the power and flexibility of our approach on receptive fields, ion channels, and Hodgkin–Huxley models. We also characterize the space of circuit configurations giving rise to rhythmic activity in the crustacean stomatogastric ganglion, and use these results to derive hypotheses for underlying compensation mechanisms. Our approach will help close the gap between data-driven and theory-driven models of neural dynamics.","lang":"eng"}],"doi":"10.7554/eLife.56261","author":[{"orcid":"0000-0002-6987-4836","last_name":"Gonçalves","full_name":"Gonçalves, Pedro J.","first_name":"Pedro J."},{"orcid":"0000-0003-4320-4663","full_name":"Lueckmann, Jan-Matthis","last_name":"Lueckmann","first_name":"Jan-Matthis"},{"orcid":"0000-0002-3573-0404","full_name":"Deistler, Michael","last_name":"Deistler","first_name":"Michael"},{"first_name":"Marcel","last_name":"Nonnenmacher","full_name":"Nonnenmacher, Marcel","orcid":"0000-0001-6044-6627"},{"full_name":"Öcal, Kaan","last_name":"Öcal","first_name":"Kaan","orcid":"0000-0002-8528-6858"},{"full_name":"Bassetto, Giacomo","last_name":"Bassetto","first_name":"Giacomo"},{"orcid":"0000-0003-4252-1608","full_name":"Chintaluri, Chaitanya","last_name":"Chintaluri","id":"BA06AFEE-A4BA-11EA-AE5C-14673DDC885E","first_name":"Chaitanya"},{"last_name":"Podlaski","full_name":"Podlaski, William F.","first_name":"William F.","orcid":"0000-0001-6619-7502"},{"first_name":"Sara A.","last_name":"Haddad","full_name":"Haddad, Sara A.","orcid":"0000-0003-0807-0823"},{"full_name":"Vogels, Tim P","last_name":"Vogels","id":"CB6FF8D2-008F-11EA-8E08-2637E6697425","first_name":"Tim P","orcid":"0000-0003-3295-6181"},{"last_name":"Greenberg","full_name":"Greenberg, David S.","first_name":"David S."},{"first_name":"Jakob H.","full_name":"Macke, Jakob H.","last_name":"Macke","orcid":"0000-0001-5154-8912"}],"title":"Training deep neural density estimators to identify mechanistic models of neural dynamics","_id":"8127","status":"public","publication_status":"published","acknowledgement":"We thank Mahmood S Hoseini and Michael Stryker for sharing their data for Figure 2, and Philipp Berens, Sean Bittner, Jan Boelts, John Cunningham, Richard Gao, Scott Linderman, Eve Marder, Iain Murray, George Papamakarios, Astrid Prinz, Auguste Schulz and Srinivas Turaga for discussions and/or comments on the manuscript. This work was supported by the German Research Foundation (DFG) through SFB 1233 ‘Robust Vision’, (276693517), SFB 1089 ‘Synaptic Microcircuits’, SPP 2041 ‘Computational Connectomics’ and Germany's Excellence Strategy – EXC-Number 2064/1 – Project number 390727645 and the German Federal Ministry of Education and Research (BMBF, project ‘ADIMEM’, FKZ 01IS18052 A-D) to JHM, a Sir Henry Dale Fellowship by the Wellcome Trust and the Royal Society (WT100000; WFP and TPV), a Wellcome Trust Senior Research Fellowship (214316/Z/18/Z; TPV), a ERC Consolidator Grant (SYNAPSEEK; WPF and CC), and a UK Research and Innovation, Biotechnology and Biological Sciences Research Council (CC, UKRI-BBSRC BB/N019512/1). We gratefully acknowledge the Leibniz Supercomputing Centre for funding this project by providing computing time on its Linux-Cluster.","ec_funded":1,"publication_identifier":{"eissn":["2050-084X"]},"project":[{"grant_number":"819603","_id":"0aacfa84-070f-11eb-9043-d7eb2c709234","name":"Learning the shape of synaptic plasticity rules for neuronal architectures and function through machine learning.","call_identifier":"H2020"}],"oa_version":"Published Version","day":"17","citation":{"ista":"Gonçalves PJ, Lueckmann J-M, Deistler M, Nonnenmacher M, Öcal K, Bassetto G, Chintaluri C, Podlaski WF, Haddad SA, Vogels TP, Greenberg DS, Macke JH. 2020. Training deep neural density estimators to identify mechanistic models of neural dynamics. eLife. 9, e56261.","ama":"Gonçalves PJ, Lueckmann J-M, Deistler M, et al. Training deep neural density estimators to identify mechanistic models of neural dynamics. <i>eLife</i>. 2020;9. doi:<a href=\"https://doi.org/10.7554/eLife.56261\">10.7554/eLife.56261</a>","short":"P.J. Gonçalves, J.-M. Lueckmann, M. Deistler, M. Nonnenmacher, K. Öcal, G. Bassetto, C. Chintaluri, W.F. Podlaski, S.A. Haddad, T.P. Vogels, D.S. Greenberg, J.H. Macke, ELife 9 (2020).","apa":"Gonçalves, P. J., Lueckmann, J.-M., Deistler, M., Nonnenmacher, M., Öcal, K., Bassetto, G., … Macke, J. H. (2020). Training deep neural density estimators to identify mechanistic models of neural dynamics. <i>ELife</i>. eLife Sciences Publications. <a href=\"https://doi.org/10.7554/eLife.56261\">https://doi.org/10.7554/eLife.56261</a>","ieee":"P. J. Gonçalves <i>et al.</i>, “Training deep neural density estimators to identify mechanistic models of neural dynamics,” <i>eLife</i>, vol. 9. eLife Sciences Publications, 2020.","chicago":"Gonçalves, Pedro J., Jan-Matthis Lueckmann, Michael Deistler, Marcel Nonnenmacher, Kaan Öcal, Giacomo Bassetto, Chaitanya Chintaluri, et al. “Training Deep Neural Density Estimators to Identify Mechanistic Models of Neural Dynamics.” <i>ELife</i>. eLife Sciences Publications, 2020. <a href=\"https://doi.org/10.7554/eLife.56261\">https://doi.org/10.7554/eLife.56261</a>.","mla":"Gonçalves, Pedro J., et al. “Training Deep Neural Density Estimators to Identify Mechanistic Models of Neural Dynamics.” <i>ELife</i>, vol. 9, e56261, eLife Sciences Publications, 2020, doi:<a href=\"https://doi.org/10.7554/eLife.56261\">10.7554/eLife.56261</a>."},"ddc":["570"],"file_date_updated":"2020-10-27T11:37:32Z","pmid":1,"month":"09","has_accepted_license":"1","volume":9,"article_processing_charge":"No","file":[{"date_created":"2020-10-27T11:37:32Z","file_id":"8709","creator":"cziletti","relation":"main_file","file_size":17355867,"file_name":"2020_eLife_Gonçalves.pdf","date_updated":"2020-10-27T11:37:32Z","success":1,"content_type":"application/pdf","checksum":"c4300ddcd93ed03fc9c6cdf1f77890be","access_level":"open_access"}],"tmp":{"name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","image":"/images/cc_by.png","short":"CC BY (4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode"}},{"department":[{"_id":"RoSe"}],"user_id":"c635000d-4b10-11ee-a964-aac5a93f6ac1","date_published":"2020-11-01T00:00:00Z","external_id":{"arxiv":["1907.04547"],"isi":["000550164400001"]},"scopus_import":"1","date_created":"2020-07-18T15:06:35Z","intvolume":"       238","publisher":"Springer Nature","isi":1,"language":[{"iso":"eng"}],"type":"journal_article","quality_controlled":"1","oa":1,"year":"2020","publication":"Archive for Rational Mechanics and Analysis","date_updated":"2023-09-05T14:19:06Z","article_type":"original","page":"541-606","day":"01","citation":{"apa":"Bossmann, L. (2020). Derivation of the 2d Gross–Pitaevskii equation for strongly confined 3d Bosons. <i>Archive for Rational Mechanics and Analysis</i>. Springer Nature. <a href=\"https://doi.org/10.1007/s00205-020-01548-w\">https://doi.org/10.1007/s00205-020-01548-w</a>","ieee":"L. Bossmann, “Derivation of the 2d Gross–Pitaevskii equation for strongly confined 3d Bosons,” <i>Archive for Rational Mechanics and Analysis</i>, vol. 238, no. 11. Springer Nature, pp. 541–606, 2020.","short":"L. Bossmann, Archive for Rational Mechanics and Analysis 238 (2020) 541–606.","ama":"Bossmann L. Derivation of the 2d Gross–Pitaevskii equation for strongly confined 3d Bosons. <i>Archive for Rational Mechanics and Analysis</i>. 2020;238(11):541-606. doi:<a href=\"https://doi.org/10.1007/s00205-020-01548-w\">10.1007/s00205-020-01548-w</a>","ista":"Bossmann L. 2020. Derivation of the 2d Gross–Pitaevskii equation for strongly confined 3d Bosons. Archive for Rational Mechanics and Analysis. 238(11), 541–606.","chicago":"Bossmann, Lea. “Derivation of the 2d Gross–Pitaevskii Equation for Strongly Confined 3d Bosons.” <i>Archive for Rational Mechanics and Analysis</i>. Springer Nature, 2020. <a href=\"https://doi.org/10.1007/s00205-020-01548-w\">https://doi.org/10.1007/s00205-020-01548-w</a>.","mla":"Bossmann, Lea. “Derivation of the 2d Gross–Pitaevskii Equation for Strongly Confined 3d Bosons.” <i>Archive for Rational Mechanics and Analysis</i>, vol. 238, no. 11, Springer Nature, 2020, pp. 541–606, doi:<a href=\"https://doi.org/10.1007/s00205-020-01548-w\">10.1007/s00205-020-01548-w</a>."},"month":"11","file_date_updated":"2020-12-02T08:50:38Z","ddc":["510"],"oa_version":"Published Version","tmp":{"name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","image":"/images/cc_by.png","short":"CC BY (4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode"},"arxiv":1,"file":[{"creator":"dernst","relation":"main_file","file_size":942343,"file_name":"2020_ArchiveRatMech_Bossmann.pdf","content_type":"application/pdf","checksum":"cc67a79a67bef441625fcb1cd031db3d","access_level":"open_access","date_updated":"2020-12-02T08:50:38Z","success":1,"date_created":"2020-12-02T08:50:38Z","file_id":"8826"}],"has_accepted_license":"1","volume":238,"article_processing_charge":"Yes (via OA deal)","author":[{"orcid":"0000-0002-6854-1343","last_name":"Bossmann","full_name":"Bossmann, Lea","first_name":"Lea","id":"A2E3BCBE-5FCC-11E9-AA4B-76F3E5697425"}],"title":"Derivation of the 2d Gross–Pitaevskii equation for strongly confined 3d Bosons","_id":"8130","issue":"11","abstract":[{"lang":"eng","text":"We study the dynamics of a system of N interacting bosons in a disc-shaped trap, which is realised by an external potential that confines the bosons in one spatial dimension to an interval of length of order ε. The interaction is non-negative and scaled in such a way that its scattering length is of order ε/N, while its range is proportional to (ε/N)β with scaling parameter β∈(0,1]. We consider the simultaneous limit (N,ε)→(∞,0) and assume that the system initially exhibits Bose–Einstein condensation. We prove that condensation is preserved by the N-body dynamics, where the time-evolved condensate wave function is the solution of a two-dimensional non-linear equation. The strength of the non-linearity depends on the scaling parameter β. For β∈(0,1), we obtain a cubic defocusing non-linear Schrödinger equation, while the choice β=1 yields a Gross–Pitaevskii equation featuring the scattering length of the interaction. In both cases, the coupling parameter depends on the confining potential."}],"doi":"10.1007/s00205-020-01548-w","publication_identifier":{"issn":["0003-9527"],"eissn":["1432-0673"]},"project":[{"_id":"260C2330-B435-11E9-9278-68D0E5697425","grant_number":"754411","call_identifier":"H2020","name":"ISTplus - Postdoctoral Fellowships"},{"name":"IST Austria Open Access Fund","_id":"B67AFEDC-15C9-11EA-A837-991A96BB2854"}],"acknowledgement":"Open access funding provided by Institute of Science and Technology (IST Austria). I thank Stefan Teufel for helpful remarks and for his involvement in the closely related joint project [10]. Helpful discussions with Serena Cenatiempo and Nikolai Leopold are gratefully acknowledged. This work was supported by the German Research Foundation within the Research Training Group 1838 “Spectral Theory and Dynamics of Quantum Systems” and has received funding from the European Union’s Horizon 2020 research and innovation programme under the Marie Skłodowska-Curie Grant Agreement No. 754411.","publication_status":"published","status":"public","ec_funded":1},{"user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","department":[{"_id":"GaNo"}],"scopus_import":"1","date_created":"2020-07-19T22:00:58Z","external_id":{"pmid":["32659636"],"isi":["000598918900019"]},"date_published":"2020-12-01T00:00:00Z","intvolume":"        65","publisher":"Elsevier","quality_controlled":"1","type":"journal_article","language":[{"iso":"eng"}],"isi":1,"oa":1,"year":"2020","date_updated":"2024-09-10T12:04:25Z","publication":"Current Opinion in Genetics and Development","article_type":"original","page":"126-137","related_material":{"record":[{"relation":"dissertation_contains","status":"public","id":"8620"}]},"file_date_updated":"2020-07-22T06:47:45Z","ddc":["570"],"pmid":1,"month":"12","day":"01","citation":{"ieee":"B. Basilico, J. Morandell, and G. Novarino, “Molecular mechanisms for targeted ASD treatments,” <i>Current Opinion in Genetics and Development</i>, vol. 65, no. 12. Elsevier, pp. 126–137, 2020.","apa":"Basilico, B., Morandell, J., &#38; Novarino, G. (2020). Molecular mechanisms for targeted ASD treatments. <i>Current Opinion in Genetics and Development</i>. Elsevier. <a href=\"https://doi.org/10.1016/j.gde.2020.06.004\">https://doi.org/10.1016/j.gde.2020.06.004</a>","ama":"Basilico B, Morandell J, Novarino G. Molecular mechanisms for targeted ASD treatments. <i>Current Opinion in Genetics and Development</i>. 2020;65(12):126-137. doi:<a href=\"https://doi.org/10.1016/j.gde.2020.06.004\">10.1016/j.gde.2020.06.004</a>","ista":"Basilico B, Morandell J, Novarino G. 2020. Molecular mechanisms for targeted ASD treatments. Current Opinion in Genetics and Development. 65(12), 126–137.","short":"B. Basilico, J. Morandell, G. Novarino, Current Opinion in Genetics and Development 65 (2020) 126–137.","chicago":"Basilico, Bernadette, Jasmin Morandell, and Gaia Novarino. “Molecular Mechanisms for Targeted ASD Treatments.” <i>Current Opinion in Genetics and Development</i>. Elsevier, 2020. <a href=\"https://doi.org/10.1016/j.gde.2020.06.004\">https://doi.org/10.1016/j.gde.2020.06.004</a>.","mla":"Basilico, Bernadette, et al. “Molecular Mechanisms for Targeted ASD Treatments.” <i>Current Opinion in Genetics and Development</i>, vol. 65, no. 12, Elsevier, 2020, pp. 126–37, doi:<a href=\"https://doi.org/10.1016/j.gde.2020.06.004\">10.1016/j.gde.2020.06.004</a>."},"oa_version":"Published Version","license":"https://creativecommons.org/licenses/by-nc-nd/4.0/","file":[{"file_id":"8146","date_created":"2020-07-22T06:47:45Z","success":1,"date_updated":"2020-07-22T06:47:45Z","access_level":"open_access","content_type":"application/pdf","file_name":"2020_CurrentOpGenetics_Basilico.pdf","creator":"dernst","file_size":1381545,"relation":"main_file"}],"tmp":{"name":"Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)","image":"/images/cc_by_nc_nd.png","short":"CC BY-NC-ND (4.0)","legal_code_url":"https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode"},"volume":65,"article_processing_charge":"Yes (via OA deal)","has_accepted_license":"1","_id":"8131","author":[{"orcid":"0000-0003-1843-3173","full_name":"Basilico, Bernadette","last_name":"Basilico","id":"36035796-5ACA-11E9-A75E-7AF2E5697425","first_name":"Bernadette"},{"first_name":"Jasmin","id":"4739D480-F248-11E8-B48F-1D18A9856A87","last_name":"Morandell","full_name":"Morandell, Jasmin"},{"first_name":"Gaia","id":"3E57A680-F248-11E8-B48F-1D18A9856A87","last_name":"Novarino","full_name":"Novarino, Gaia","orcid":"0000-0002-7673-7178"}],"title":"Molecular mechanisms for targeted ASD treatments","doi":"10.1016/j.gde.2020.06.004","issue":"12","abstract":[{"lang":"eng","text":"The possibility to generate construct valid animal models enabled the development and testing of therapeutic strategies targeting the core features of autism spectrum disorders (ASDs). At the same time, these studies highlighted the necessity of identifying sensitive developmental time windows for successful therapeutic interventions. Animal and human studies also uncovered the possibility to stratify the variety of ASDs in molecularly distinct subgroups, potentially facilitating effective treatment design. Here, we focus on the molecular pathways emerging as commonly affected by mutations in diverse ASD-risk genes, on their role during critical windows of brain development and the potential treatments targeting these biological processes."}],"project":[{"name":"ISTplus - Postdoctoral Fellowships","call_identifier":"H2020","grant_number":"754411","_id":"260C2330-B435-11E9-9278-68D0E5697425"},{"grant_number":"W1232-B24","_id":"2548AE96-B435-11E9-9278-68D0E5697425","name":"Molecular Drug Targets","call_identifier":"FWF"},{"_id":"05A0D778-7A3F-11EA-A408-12923DDC885E","grant_number":"F07807","name":"Neural stem cells in autism and epilepsy"}],"publication_identifier":{"issn":["0959437X"],"eissn":["18790380"]},"ec_funded":1,"status":"public","publication_status":"published"},{"year":"2020","publication":"Science Immunology","date_updated":"2023-08-22T07:56:04Z","article_number":"eabc3979","article_type":"original","department":[{"_id":"MiSi"}],"user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","external_id":{"pmid":["32646852"],"isi":["000546994600004"]},"date_published":"2020-07-10T00:00:00Z","date_created":"2020-07-19T22:00:58Z","scopus_import":"1","publisher":"AAAS","intvolume":"         5","isi":1,"language":[{"iso":"eng"}],"quality_controlled":"1","type":"journal_article","title":"The cytoskeletal regulator HEM1 governs B cell development and prevents autoimmunity","author":[{"first_name":"Elisabeth","full_name":"Salzer, Elisabeth","last_name":"Salzer"},{"last_name":"Zoghi","full_name":"Zoghi, Samaneh","first_name":"Samaneh"},{"first_name":"Máté G.","full_name":"Kiss, Máté G.","last_name":"Kiss"},{"full_name":"Kage, Frieda","last_name":"Kage","first_name":"Frieda"},{"last_name":"Rashkova","full_name":"Rashkova, Christina","first_name":"Christina"},{"first_name":"Stephanie","full_name":"Stahnke, Stephanie","last_name":"Stahnke"},{"full_name":"Haimel, Matthias","last_name":"Haimel","first_name":"Matthias"},{"last_name":"Platzer","full_name":"Platzer, René","first_name":"René"},{"first_name":"Michael","last_name":"Caldera","full_name":"Caldera, Michael"},{"first_name":"Rico Chandra","full_name":"Ardy, Rico Chandra","last_name":"Ardy"},{"first_name":"Birgit","last_name":"Hoeger","full_name":"Hoeger, Birgit"},{"first_name":"Jana","full_name":"Block, Jana","last_name":"Block"},{"last_name":"Medgyesi","full_name":"Medgyesi, David","first_name":"David"},{"first_name":"Celine","last_name":"Sin","full_name":"Sin, Celine"},{"last_name":"Shahkarami","full_name":"Shahkarami, Sepideh","first_name":"Sepideh"},{"first_name":"Renate","last_name":"Kain","full_name":"Kain, Renate"},{"first_name":"Vahid","last_name":"Ziaee","full_name":"Ziaee, Vahid"},{"last_name":"Hammerl","full_name":"Hammerl, Peter","first_name":"Peter"},{"first_name":"Christoph","full_name":"Bock, Christoph","last_name":"Bock"},{"last_name":"Menche","full_name":"Menche, Jörg","first_name":"Jörg"},{"first_name":"Loïc","last_name":"Dupré","full_name":"Dupré, Loïc"},{"last_name":"Huppa","full_name":"Huppa, Johannes B.","first_name":"Johannes B."},{"last_name":"Sixt","full_name":"Sixt, Michael K","first_name":"Michael K","id":"41E9FBEA-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-6620-9179"},{"last_name":"Lomakin","full_name":"Lomakin, Alexis","first_name":"Alexis"},{"first_name":"Klemens","last_name":"Rottner","full_name":"Rottner, Klemens"},{"first_name":"Christoph J.","full_name":"Binder, Christoph J.","last_name":"Binder"},{"full_name":"Stradal, Theresia E.B.","last_name":"Stradal","first_name":"Theresia E.B."},{"last_name":"Rezaei","full_name":"Rezaei, Nima","first_name":"Nima"},{"last_name":"Boztug","full_name":"Boztug, Kaan","first_name":"Kaan"}],"_id":"8132","abstract":[{"lang":"eng","text":"The WAVE regulatory complex (WRC) is crucial for assembly of the peripheral branched actin network constituting one of the main drivers of eukaryotic cell migration. Here, we uncover an essential role of the hematopoietic-specific WRC component HEM1 for immune cell development. Germline-encoded HEM1 deficiency underlies an inborn error of immunity with systemic autoimmunity, at cellular level marked by WRC destabilization, reduced filamentous actin, and failure to assemble lamellipodia. Hem1−/− mice display systemic autoimmunity, phenocopying the human disease. In the absence of Hem1, B cells become deprived of extracellular stimuli necessary to maintain the strength of B cell receptor signaling at a level permissive for survival of non-autoreactive B cells. This shifts the balance of B cell fate choices toward autoreactive B cells and thus autoimmunity."}],"issue":"49","doi":"10.1126/sciimmunol.abc3979","publication_identifier":{"eissn":["24709468"]},"status":"public","publication_status":"published","citation":{"mla":"Salzer, Elisabeth, et al. “The Cytoskeletal Regulator HEM1 Governs B Cell Development and Prevents Autoimmunity.” <i>Science Immunology</i>, vol. 5, no. 49, eabc3979, AAAS, 2020, doi:<a href=\"https://doi.org/10.1126/sciimmunol.abc3979\">10.1126/sciimmunol.abc3979</a>.","chicago":"Salzer, Elisabeth, Samaneh Zoghi, Máté G. Kiss, Frieda Kage, Christina Rashkova, Stephanie Stahnke, Matthias Haimel, et al. “The Cytoskeletal Regulator HEM1 Governs B Cell Development and Prevents Autoimmunity.” <i>Science Immunology</i>. AAAS, 2020. <a href=\"https://doi.org/10.1126/sciimmunol.abc3979\">https://doi.org/10.1126/sciimmunol.abc3979</a>.","apa":"Salzer, E., Zoghi, S., Kiss, M. G., Kage, F., Rashkova, C., Stahnke, S., … Boztug, K. (2020). The cytoskeletal regulator HEM1 governs B cell development and prevents autoimmunity. <i>Science Immunology</i>. AAAS. <a href=\"https://doi.org/10.1126/sciimmunol.abc3979\">https://doi.org/10.1126/sciimmunol.abc3979</a>","ieee":"E. Salzer <i>et al.</i>, “The cytoskeletal regulator HEM1 governs B cell development and prevents autoimmunity,” <i>Science Immunology</i>, vol. 5, no. 49. AAAS, 2020.","ama":"Salzer E, Zoghi S, Kiss MG, et al. The cytoskeletal regulator HEM1 governs B cell development and prevents autoimmunity. <i>Science Immunology</i>. 2020;5(49). doi:<a href=\"https://doi.org/10.1126/sciimmunol.abc3979\">10.1126/sciimmunol.abc3979</a>","short":"E. Salzer, S. Zoghi, M.G. Kiss, F. Kage, C. Rashkova, S. Stahnke, M. Haimel, R. Platzer, M. Caldera, R.C. Ardy, B. Hoeger, J. Block, D. Medgyesi, C. Sin, S. Shahkarami, R. Kain, V. Ziaee, P. Hammerl, C. Bock, J. Menche, L. Dupré, J.B. Huppa, M.K. Sixt, A. Lomakin, K. Rottner, C.J. Binder, T.E.B. Stradal, N. Rezaei, K. Boztug, Science Immunology 5 (2020).","ista":"Salzer E, Zoghi S, Kiss MG, Kage F, Rashkova C, Stahnke S, Haimel M, Platzer R, Caldera M, Ardy RC, Hoeger B, Block J, Medgyesi D, Sin C, Shahkarami S, Kain R, Ziaee V, Hammerl P, Bock C, Menche J, Dupré L, Huppa JB, Sixt MK, Lomakin A, Rottner K, Binder CJ, Stradal TEB, Rezaei N, Boztug K. 2020. The cytoskeletal regulator HEM1 governs B cell development and prevents autoimmunity. Science Immunology. 5(49), eabc3979."},"day":"10","month":"07","pmid":1,"oa_version":"None","article_processing_charge":"No","volume":5},{"user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","department":[{"_id":"MaRo"}],"scopus_import":"1","date_created":"2020-07-19T22:00:58Z","date_published":"2020-07-08T00:00:00Z","external_id":{"isi":["000551778400001"],"pmid":["32641083"]},"intvolume":"        12","publisher":"Springer Nature","quality_controlled":"1","type":"journal_article","language":[{"iso":"eng"}],"isi":1,"oa":1,"year":"2020","date_updated":"2023-08-22T07:55:37Z","publication":"Genome Medicine","article_type":"original","article_number":"60","related_material":{"record":[{"id":"9706","status":"public","relation":"research_data"}]},"month":"07","pmid":1,"file_date_updated":"2020-07-22T06:27:38Z","ddc":["570"],"day":"08","citation":{"apa":"Hillary, R. F., Trejo-Banos, D., Kousathanas, A., Mccartney, D. L., Harris, S. E., Stevenson, A. J., … Marioni, R. E. (2020). Multi-method genome- and epigenome-wide studies of inflammatory protein levels in healthy older adults. <i>Genome Medicine</i>. Springer Nature. <a href=\"https://doi.org/10.1186/s13073-020-00754-1\">https://doi.org/10.1186/s13073-020-00754-1</a>","ieee":"R. F. Hillary <i>et al.</i>, “Multi-method genome- and epigenome-wide studies of inflammatory protein levels in healthy older adults,” <i>Genome Medicine</i>, vol. 12, no. 1. Springer Nature, 2020.","ama":"Hillary RF, Trejo-Banos D, Kousathanas A, et al. Multi-method genome- and epigenome-wide studies of inflammatory protein levels in healthy older adults. <i>Genome Medicine</i>. 2020;12(1). doi:<a href=\"https://doi.org/10.1186/s13073-020-00754-1\">10.1186/s13073-020-00754-1</a>","ista":"Hillary RF, Trejo-Banos D, Kousathanas A, Mccartney DL, Harris SE, Stevenson AJ, Patxot M, Ojavee SE, Zhang Q, Liewald DC, Ritchie CW, Evans KL, Tucker-Drob EM, Wray NR, Mcrae AF, Visscher PM, Deary IJ, Robinson MR, Marioni RE. 2020. Multi-method genome- and epigenome-wide studies of inflammatory protein levels in healthy older adults. Genome Medicine. 12(1), 60.","short":"R.F. Hillary, D. Trejo-Banos, A. Kousathanas, D.L. Mccartney, S.E. Harris, A.J. Stevenson, M. Patxot, S.E. Ojavee, Q. Zhang, D.C. Liewald, C.W. Ritchie, K.L. Evans, E.M. Tucker-Drob, N.R. Wray, A.F. Mcrae, P.M. Visscher, I.J. Deary, M.R. Robinson, R.E. Marioni, Genome Medicine 12 (2020).","chicago":"Hillary, Robert F., Daniel Trejo-Banos, Athanasios Kousathanas, Daniel L. Mccartney, Sarah E. Harris, Anna J. Stevenson, Marion Patxot, et al. “Multi-Method Genome- and Epigenome-Wide Studies of Inflammatory Protein Levels in Healthy Older Adults.” <i>Genome Medicine</i>. Springer Nature, 2020. <a href=\"https://doi.org/10.1186/s13073-020-00754-1\">https://doi.org/10.1186/s13073-020-00754-1</a>.","mla":"Hillary, Robert F., et al. “Multi-Method Genome- and Epigenome-Wide Studies of Inflammatory Protein Levels in Healthy Older Adults.” <i>Genome Medicine</i>, vol. 12, no. 1, 60, Springer Nature, 2020, doi:<a href=\"https://doi.org/10.1186/s13073-020-00754-1\">10.1186/s13073-020-00754-1</a>."},"oa_version":"Published Version","file":[{"file_name":"2020_GenomeMedicine_Hillary.pdf","relation":"main_file","creator":"dernst","file_size":1136983,"success":1,"date_updated":"2020-07-22T06:27:38Z","access_level":"open_access","content_type":"application/pdf","file_id":"8145","date_created":"2020-07-22T06:27:38Z"}],"tmp":{"name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","image":"/images/cc_by.png","short":"CC BY (4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode"},"volume":12,"article_processing_charge":"No","has_accepted_license":"1","_id":"8133","author":[{"first_name":"Robert F.","last_name":"Hillary","full_name":"Hillary, Robert F."},{"full_name":"Trejo-Banos, Daniel","last_name":"Trejo-Banos","first_name":"Daniel"},{"first_name":"Athanasios","last_name":"Kousathanas","full_name":"Kousathanas, Athanasios"},{"full_name":"Mccartney, Daniel L.","last_name":"Mccartney","first_name":"Daniel L."},{"full_name":"Harris, Sarah E.","last_name":"Harris","first_name":"Sarah E."},{"last_name":"Stevenson","full_name":"Stevenson, Anna J.","first_name":"Anna J."},{"first_name":"Marion","full_name":"Patxot, Marion","last_name":"Patxot"},{"first_name":"Sven Erik","full_name":"Ojavee, Sven Erik","last_name":"Ojavee"},{"last_name":"Zhang","full_name":"Zhang, Qian","first_name":"Qian"},{"first_name":"David C.","full_name":"Liewald, David C.","last_name":"Liewald"},{"first_name":"Craig W.","full_name":"Ritchie, Craig W.","last_name":"Ritchie"},{"last_name":"Evans","full_name":"Evans, Kathryn L.","first_name":"Kathryn L."},{"last_name":"Tucker-Drob","full_name":"Tucker-Drob, Elliot M.","first_name":"Elliot M."},{"first_name":"Naomi R.","full_name":"Wray, Naomi R.","last_name":"Wray"},{"last_name":"Mcrae","full_name":"Mcrae, Allan F.","first_name":"Allan F."},{"last_name":"Visscher","full_name":"Visscher, Peter M.","first_name":"Peter M."},{"full_name":"Deary, Ian J.","last_name":"Deary","first_name":"Ian J."},{"orcid":"0000-0001-8982-8813","full_name":"Robinson, Matthew Richard","last_name":"Robinson","id":"E5D42276-F5DA-11E9-8E24-6303E6697425","first_name":"Matthew Richard"},{"first_name":"Riccardo E.","full_name":"Marioni, Riccardo E.","last_name":"Marioni"}],"title":"Multi-method genome- and epigenome-wide studies of inflammatory protein levels in healthy older adults","doi":"10.1186/s13073-020-00754-1","issue":"1","abstract":[{"lang":"eng","text":"The molecular factors which control circulating levels of inflammatory proteins are not well understood. Furthermore, association studies between molecular probes and human traits are often performed by linear model-based methods which may fail to account for complex structure and interrelationships within molecular datasets.In this study, we perform genome- and epigenome-wide association studies (GWAS/EWAS) on the levels of 70 plasma-derived inflammatory protein biomarkers in healthy older adults (Lothian Birth Cohort 1936; n = 876; Olink® inflammation panel). We employ a Bayesian framework (BayesR+) which can account for issues pertaining to data structure and unknown confounding variables (with sensitivity analyses using ordinary least squares- (OLS) and mixed model-based approaches). We identified 13 SNPs associated with 13 proteins (n = 1 SNP each) concordant across OLS and Bayesian methods. We identified 3 CpG sites spread across 3 proteins (n = 1 CpG each) that were concordant across OLS, mixed-model and Bayesian analyses. Tagged genetic variants accounted for up to 45% of variance in protein levels (for MCP2, 36% of variance alone attributable to 1 polymorphism). Methylation data accounted for up to 46% of variation in protein levels (for CXCL10). Up to 66% of variation in protein levels (for VEGFA) was explained using genetic and epigenetic data combined. We demonstrated putative causal relationships between CD6 and IL18R1 with inflammatory bowel disease and between IL12B and Crohn’s disease. Our data may aid understanding of the molecular regulation of the circulating inflammatory proteome as well as causal relationships between inflammatory mediators and disease."}],"publication_identifier":{"eissn":["1756994X"]},"publication_status":"published","status":"public"},{"doi":"10.1063/5.0005950","abstract":[{"lang":"eng","text":"We prove an upper bound on the free energy of a two-dimensional homogeneous Bose gas in the thermodynamic limit. We show that for a2ρ ≪ 1 and βρ ≳ 1, the free energy per unit volume differs from the one of the non-interacting system by at most 4πρ2|lna2ρ|−1(2−[1−βc/β]2+) to leading order, where a is the scattering length of the two-body interaction potential, ρ is the density, β is the inverse temperature, and βc is the inverse Berezinskii–Kosterlitz–Thouless critical temperature for superfluidity. In combination with the corresponding matching lower bound proved by Deuchert et al. [Forum Math. Sigma 8, e20 (2020)], this shows equality in the asymptotic expansion."}],"issue":"6","_id":"8134","title":"The free energy of the two-dimensional dilute Bose gas. II. Upper bound","author":[{"last_name":"Mayer","full_name":"Mayer, Simon","first_name":"Simon","id":"30C4630A-F248-11E8-B48F-1D18A9856A87"},{"orcid":"0000-0002-6781-0521","full_name":"Seiringer, Robert","last_name":"Seiringer","id":"4AFD0470-F248-11E8-B48F-1D18A9856A87","first_name":"Robert"}],"ec_funded":1,"publication_status":"published","status":"public","project":[{"name":"Analysis of quantum many-body systems","call_identifier":"H2020","grant_number":"694227","_id":"25C6DC12-B435-11E9-9278-68D0E5697425"}],"publication_identifier":{"issn":["00222488"]},"oa_version":"Preprint","month":"06","citation":{"mla":"Mayer, Simon, and Robert Seiringer. “The Free Energy of the Two-Dimensional Dilute Bose Gas. II. Upper Bound.” <i>Journal of Mathematical Physics</i>, vol. 61, no. 6, 061901, AIP Publishing, 2020, doi:<a href=\"https://doi.org/10.1063/5.0005950\">10.1063/5.0005950</a>.","chicago":"Mayer, Simon, and Robert Seiringer. “The Free Energy of the Two-Dimensional Dilute Bose Gas. II. Upper Bound.” <i>Journal of Mathematical Physics</i>. AIP Publishing, 2020. <a href=\"https://doi.org/10.1063/5.0005950\">https://doi.org/10.1063/5.0005950</a>.","ieee":"S. Mayer and R. Seiringer, “The free energy of the two-dimensional dilute Bose gas. II. Upper bound,” <i>Journal of Mathematical Physics</i>, vol. 61, no. 6. AIP Publishing, 2020.","apa":"Mayer, S., &#38; Seiringer, R. (2020). The free energy of the two-dimensional dilute Bose gas. II. Upper bound. <i>Journal of Mathematical Physics</i>. AIP Publishing. <a href=\"https://doi.org/10.1063/5.0005950\">https://doi.org/10.1063/5.0005950</a>","ista":"Mayer S, Seiringer R. 2020. The free energy of the two-dimensional dilute Bose gas. II. Upper bound. Journal of Mathematical Physics. 61(6), 061901.","ama":"Mayer S, Seiringer R. The free energy of the two-dimensional dilute Bose gas. II. Upper bound. <i>Journal of Mathematical Physics</i>. 2020;61(6). doi:<a href=\"https://doi.org/10.1063/5.0005950\">10.1063/5.0005950</a>","short":"S. Mayer, R. Seiringer, Journal of Mathematical Physics 61 (2020)."},"day":"22","article_processing_charge":"No","volume":61,"arxiv":1,"year":"2020","oa":1,"article_number":"061901","article_type":"original","date_updated":"2023-08-22T08:12:40Z","publication":"Journal of Mathematical Physics","date_created":"2020-07-19T22:00:59Z","scopus_import":"1","external_id":{"arxiv":["2002.08281"],"isi":["000544595100001"]},"date_published":"2020-06-22T00:00:00Z","user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","department":[{"_id":"RoSe"}],"type":"journal_article","language":[{"iso":"eng"}],"quality_controlled":"1","isi":1,"publisher":"AIP Publishing","main_file_link":[{"url":"https://arxiv.org/abs/2002.08281","open_access":"1"}],"intvolume":"        61"},{"year":"2020","alternative_title":["Abel Symposia"],"oa":1,"page":"181-218","publication":"Topological Data Analysis","date_updated":"2021-01-12T08:17:06Z","date_published":"2020-06-22T00:00:00Z","date_created":"2020-07-19T22:00:59Z","scopus_import":"1","department":[{"_id":"HeEd"}],"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","language":[{"iso":"eng"}],"quality_controlled":"1","type":"conference","publisher":"Springer Nature","intvolume":"        15","abstract":[{"lang":"eng","text":"Discrete Morse theory has recently lead to new developments in the theory of random geometric complexes. This article surveys the methods and results obtained with this new approach, and discusses some of its shortcomings. It uses simulations to illustrate the results and to form conjectures, getting numerical estimates for combinatorial, topological, and geometric properties of weighted and unweighted Delaunay mosaics, their dual Voronoi tessellations, and the Alpha and Wrap complexes contained in the mosaics."}],"doi":"10.1007/978-3-030-43408-3_8","title":"Radius functions on Poisson–Delaunay mosaics and related complexes experimentally","author":[{"first_name":"Herbert","id":"3FB178DA-F248-11E8-B48F-1D18A9856A87","last_name":"Edelsbrunner","full_name":"Edelsbrunner, Herbert","orcid":"0000-0002-9823-6833"},{"full_name":"Nikitenko, Anton","last_name":"Nikitenko","id":"3E4FF1BA-F248-11E8-B48F-1D18A9856A87","first_name":"Anton"},{"full_name":"Ölsböck, Katharina","last_name":"Ölsböck","id":"4D4AA390-F248-11E8-B48F-1D18A9856A87","first_name":"Katharina"},{"first_name":"Peter","id":"331776E2-F248-11E8-B48F-1D18A9856A87","last_name":"Synak","full_name":"Synak, Peter"}],"_id":"8135","publication_status":"published","acknowledgement":"This project has received funding from the European Research Council (ERC) under the European Union’s Horizon 2020 research and innovation programme (grant agreements No 78818 Alpha and No 638176). It is also partially supported by the DFG Collaborative Research Center TRR 109, ‘Discretization in Geometry and Dynamics’, through grant no. I02979-N35 of the Austrian Science Fund (FWF).","status":"public","ec_funded":1,"publication_identifier":{"eissn":["21978549"],"isbn":["9783030434076"],"issn":["21932808"]},"project":[{"call_identifier":"H2020","name":"Alpha Shape Theory Extended","grant_number":"788183","_id":"266A2E9E-B435-11E9-9278-68D0E5697425"},{"grant_number":"638176","_id":"2533E772-B435-11E9-9278-68D0E5697425","name":"Efficient Simulation of Natural Phenomena at Extremely Large Scales","call_identifier":"H2020"},{"grant_number":"I02979-N35","_id":"2561EBF4-B435-11E9-9278-68D0E5697425","call_identifier":"FWF","name":"Persistence and stability of geometric complexes"}],"oa_version":"Submitted Version","citation":{"ama":"Edelsbrunner H, Nikitenko A, Ölsböck K, Synak P. Radius functions on Poisson–Delaunay mosaics and related complexes experimentally. In: <i>Topological Data Analysis</i>. Vol 15. Springer Nature; 2020:181-218. doi:<a href=\"https://doi.org/10.1007/978-3-030-43408-3_8\">10.1007/978-3-030-43408-3_8</a>","ista":"Edelsbrunner H, Nikitenko A, Ölsböck K, Synak P. 2020. Radius functions on Poisson–Delaunay mosaics and related complexes experimentally. Topological Data Analysis. , Abel Symposia, vol. 15, 181–218.","short":"H. Edelsbrunner, A. Nikitenko, K. Ölsböck, P. Synak, in:, Topological Data Analysis, Springer Nature, 2020, pp. 181–218.","apa":"Edelsbrunner, H., Nikitenko, A., Ölsböck, K., &#38; Synak, P. (2020). Radius functions on Poisson–Delaunay mosaics and related complexes experimentally. In <i>Topological Data Analysis</i> (Vol. 15, pp. 181–218). Springer Nature. <a href=\"https://doi.org/10.1007/978-3-030-43408-3_8\">https://doi.org/10.1007/978-3-030-43408-3_8</a>","ieee":"H. Edelsbrunner, A. Nikitenko, K. Ölsböck, and P. Synak, “Radius functions on Poisson–Delaunay mosaics and related complexes experimentally,” in <i>Topological Data Analysis</i>, 2020, vol. 15, pp. 181–218.","chicago":"Edelsbrunner, Herbert, Anton Nikitenko, Katharina Ölsböck, and Peter Synak. “Radius Functions on Poisson–Delaunay Mosaics and Related Complexes Experimentally.” In <i>Topological Data Analysis</i>, 15:181–218. Springer Nature, 2020. <a href=\"https://doi.org/10.1007/978-3-030-43408-3_8\">https://doi.org/10.1007/978-3-030-43408-3_8</a>.","mla":"Edelsbrunner, Herbert, et al. “Radius Functions on Poisson–Delaunay Mosaics and Related Complexes Experimentally.” <i>Topological Data Analysis</i>, vol. 15, Springer Nature, 2020, pp. 181–218, doi:<a href=\"https://doi.org/10.1007/978-3-030-43408-3_8\">10.1007/978-3-030-43408-3_8</a>."},"day":"22","ddc":["510"],"month":"06","file_date_updated":"2020-10-08T08:56:14Z","has_accepted_license":"1","volume":15,"article_processing_charge":"No","file":[{"date_created":"2020-10-08T08:56:14Z","file_id":"8628","creator":"dernst","file_size":2207071,"relation":"main_file","file_name":"2020-B-01-PoissonExperimentalSurvey.pdf","content_type":"application/pdf","checksum":"7b5e0de10675d787a2ddb2091370b8d8","access_level":"open_access","date_updated":"2020-10-08T08:56:14Z","success":1}]},{"tmp":{"name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","image":"/images/cc_by.png","short":"CC BY (4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode"},"file":[{"file_id":"8148","date_created":"2020-07-22T08:32:55Z","file_name":"2020_NatureComm_Zhang.pdf","file_size":1759490,"relation":"main_file","creator":"dernst","access_level":"open_access","content_type":"application/pdf","success":1,"date_updated":"2020-07-22T08:32:55Z"}],"article_processing_charge":"No","volume":11,"has_accepted_license":"1","pmid":1,"ddc":["580"],"file_date_updated":"2020-07-22T08:32:55Z","month":"07","day":"14","citation":{"chicago":"Zhang, J, E Mazur, J Balla, Michelle C Gallei, P Kalousek, Z Medveďová, Y Li, et al. “Strigolactones Inhibit Auxin Feedback on PIN-Dependent Auxin Transport Canalization.” <i>Nature Communications</i>. Springer Nature, 2020. <a href=\"https://doi.org/10.1038/s41467-020-17252-y\">https://doi.org/10.1038/s41467-020-17252-y</a>.","mla":"Zhang, J., et al. “Strigolactones Inhibit Auxin Feedback on PIN-Dependent Auxin Transport Canalization.” <i>Nature Communications</i>, vol. 11, no. 1, Springer Nature, 2020, p. 3508, doi:<a href=\"https://doi.org/10.1038/s41467-020-17252-y\">10.1038/s41467-020-17252-y</a>.","ista":"Zhang J, Mazur E, Balla J, Gallei MC, Kalousek P, Medveďová Z, Li Y, Wang Y, Prat T, Vasileva MK, Reinöhl V, Procházka S, Halouzka R, Tarkowski P, Luschnig C, Brewer P, Friml J. 2020. Strigolactones inhibit auxin feedback on PIN-dependent auxin transport canalization. Nature Communications. 11(1), 3508.","ama":"Zhang J, Mazur E, Balla J, et al. Strigolactones inhibit auxin feedback on PIN-dependent auxin transport canalization. <i>Nature Communications</i>. 2020;11(1):3508. doi:<a href=\"https://doi.org/10.1038/s41467-020-17252-y\">10.1038/s41467-020-17252-y</a>","short":"J. Zhang, E. Mazur, J. Balla, M.C. Gallei, P. Kalousek, Z. Medveďová, Y. Li, Y. Wang, T. Prat, M.K. Vasileva, V. Reinöhl, S. Procházka, R. Halouzka, P. Tarkowski, C. Luschnig, P. Brewer, J. Friml, Nature Communications 11 (2020) 3508.","apa":"Zhang, J., Mazur, E., Balla, J., Gallei, M. C., Kalousek, P., Medveďová, Z., … Friml, J. (2020). Strigolactones inhibit auxin feedback on PIN-dependent auxin transport canalization. <i>Nature Communications</i>. Springer Nature. <a href=\"https://doi.org/10.1038/s41467-020-17252-y\">https://doi.org/10.1038/s41467-020-17252-y</a>","ieee":"J. Zhang <i>et al.</i>, “Strigolactones inhibit auxin feedback on PIN-dependent auxin transport canalization,” <i>Nature Communications</i>, vol. 11, no. 1. Springer Nature, p. 3508, 2020."},"oa_version":"Published Version","project":[{"grant_number":"742985","_id":"261099A6-B435-11E9-9278-68D0E5697425","name":"Tracing Evolution of Auxin Transport and Polarity in Plants","call_identifier":"H2020"}],"publication_identifier":{"issn":["2041-1723"]},"ec_funded":1,"status":"public","publication_status":"published","acknowledgement":"We are grateful to David Nelson for providing published materials and extremely helpful comments, and Elizabeth Dun and Christine Beveridge for helpful discussions. The research leading to these results has received funding from the European Research Council (ERC) under the European Union's Horizon 2020 research and innovation programme (742985). This work was also supported by the Beijing Municipal Natural Science Foundation (5192011), Beijing Outstanding University Discipline Program, the National Natural Science Foundation of China (31370309), CEITEC 2020 (LQ1601) project with financial contribution made by the Ministry of Education, Youth and Sports of the Czech Republic within special support paid from the National Program of Sustainability II funds, Australian Research Council (FT180100081), and China Postdoctoral Science Foundation (2019M660864).","_id":"8138","author":[{"first_name":"J","full_name":"Zhang, J","last_name":"Zhang"},{"last_name":"Mazur","full_name":"Mazur, E","first_name":"E"},{"full_name":"Balla, J","last_name":"Balla","first_name":"J"},{"id":"35A03822-F248-11E8-B48F-1D18A9856A87","first_name":"Michelle C","full_name":"Gallei, Michelle C","last_name":"Gallei","orcid":"0000-0003-1286-7368"},{"first_name":"P","full_name":"Kalousek, P","last_name":"Kalousek"},{"first_name":"Z","last_name":"Medveďová","full_name":"Medveďová, Z"},{"full_name":"Li, Y","last_name":"Li","first_name":"Y"},{"first_name":"Y","full_name":"Wang, Y","last_name":"Wang"},{"id":"3DA3BFEE-F248-11E8-B48F-1D18A9856A87","first_name":"Tomas","full_name":"Prat, Tomas","last_name":"Prat"},{"first_name":"Mina K","id":"3407EB18-F248-11E8-B48F-1D18A9856A87","last_name":"Vasileva","full_name":"Vasileva, Mina K"},{"first_name":"V","last_name":"Reinöhl","full_name":"Reinöhl, V"},{"first_name":"S","full_name":"Procházka, S","last_name":"Procházka"},{"first_name":"R","full_name":"Halouzka, R","last_name":"Halouzka"},{"first_name":"P","last_name":"Tarkowski","full_name":"Tarkowski, P"},{"first_name":"C","last_name":"Luschnig","full_name":"Luschnig, C"},{"first_name":"PB","last_name":"Brewer","full_name":"Brewer, PB"},{"orcid":"0000-0002-8302-7596","last_name":"Friml","full_name":"Friml, Jiří","first_name":"Jiří","id":"4159519E-F248-11E8-B48F-1D18A9856A87"}],"title":"Strigolactones inhibit auxin feedback on PIN-dependent auxin transport canalization","doi":"10.1038/s41467-020-17252-y","issue":"1","abstract":[{"text":"Directional transport of the phytohormone auxin is a versatile, plant-specific mechanism regulating many aspects of plant development. The recently identified plant hormones, strigolactones (SLs), are implicated in many plant traits; among others, they modify the phenotypic output of PIN-FORMED (PIN) auxin transporters for fine-tuning of growth and developmental responses. Here, we show in pea and Arabidopsis that SLs target processes dependent on the canalization of auxin flow, which involves auxin feedback on PIN subcellular distribution. D14 receptor- and MAX2 F-box-mediated SL signaling inhibits the formation of auxin-conducting channels after wounding or from artificial auxin sources, during vasculature de novo formation and regeneration. At the cellular level, SLs interfere with auxin effects on PIN polar targeting, constitutive PIN trafficking as well as clathrin-mediated endocytosis. Our results identify a non-transcriptional mechanism of SL action, uncoupling auxin feedback on PIN polarity and trafficking, thereby regulating vascular tissue formation and regeneration.","lang":"eng"}],"intvolume":"        11","publisher":"Springer Nature","language":[{"iso":"eng"}],"type":"journal_article","quality_controlled":"1","isi":1,"user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","department":[{"_id":"JiFr"}],"scopus_import":"1","date_created":"2020-07-21T08:58:07Z","date_published":"2020-07-14T00:00:00Z","external_id":{"pmid":["32665554"],"isi":["000550062200004"]},"date_updated":"2023-08-22T08:13:44Z","publication":"Nature Communications","article_type":"original","page":"3508","related_material":{"record":[{"id":"11626","relation":"dissertation_contains","status":"public"}]},"oa":1,"year":"2020"},{"acknowledged_ssus":[{"_id":"EM-Fac"},{"_id":"Bio"}],"scopus_import":"1","date_created":"2020-07-21T08:58:19Z","external_id":{"pmid":["32616560"],"isi":["000561047900021"]},"date_published":"2020-08-06T00:00:00Z","user_id":"c635000d-4b10-11ee-a964-aac5a93f6ac1","department":[{"_id":"JiFr"},{"_id":"EM-Fac"}],"quality_controlled":"1","type":"journal_article","language":[{"iso":"eng"}],"isi":1,"intvolume":"       133","publisher":"The Company of Biologists","year":"2020","oa":1,"article_type":"original","article_number":"jcs248062","related_material":{"record":[{"id":"14510","status":"public","relation":"dissertation_contains"}]},"date_updated":"2023-12-01T13:51:07Z","publication":"Journal of Cell Science","oa_version":"Published Version","ddc":["575"],"file_date_updated":"2021-08-08T22:30:03Z","pmid":1,"month":"08","day":"06","citation":{"chicago":"Johnson, Alexander J, Nataliia Gnyliukh, Walter Kaufmann, Madhumitha Narasimhan, G Vert, SY Bednarek, and Jiří Friml. “Experimental Toolbox for Quantitative Evaluation of Clathrin-Mediated Endocytosis in the Plant Model Arabidopsis.” <i>Journal of Cell Science</i>. The Company of Biologists, 2020. <a href=\"https://doi.org/10.1242/jcs.248062\">https://doi.org/10.1242/jcs.248062</a>.","mla":"Johnson, Alexander J., et al. “Experimental Toolbox for Quantitative Evaluation of Clathrin-Mediated Endocytosis in the Plant Model Arabidopsis.” <i>Journal of Cell Science</i>, vol. 133, no. 15, jcs248062, The Company of Biologists, 2020, doi:<a href=\"https://doi.org/10.1242/jcs.248062\">10.1242/jcs.248062</a>.","ieee":"A. J. Johnson <i>et al.</i>, “Experimental toolbox for quantitative evaluation of clathrin-mediated endocytosis in the plant model Arabidopsis,” <i>Journal of Cell Science</i>, vol. 133, no. 15. The Company of Biologists, 2020.","apa":"Johnson, A. J., Gnyliukh, N., Kaufmann, W., Narasimhan, M., Vert, G., Bednarek, S., &#38; Friml, J. (2020). Experimental toolbox for quantitative evaluation of clathrin-mediated endocytosis in the plant model Arabidopsis. <i>Journal of Cell Science</i>. The Company of Biologists. <a href=\"https://doi.org/10.1242/jcs.248062\">https://doi.org/10.1242/jcs.248062</a>","ama":"Johnson AJ, Gnyliukh N, Kaufmann W, et al. Experimental toolbox for quantitative evaluation of clathrin-mediated endocytosis in the plant model Arabidopsis. <i>Journal of Cell Science</i>. 2020;133(15). doi:<a href=\"https://doi.org/10.1242/jcs.248062\">10.1242/jcs.248062</a>","ista":"Johnson AJ, Gnyliukh N, Kaufmann W, Narasimhan M, Vert G, Bednarek S, Friml J. 2020. Experimental toolbox for quantitative evaluation of clathrin-mediated endocytosis in the plant model Arabidopsis. Journal of Cell Science. 133(15), jcs248062.","short":"A.J. Johnson, N. Gnyliukh, W. Kaufmann, M. Narasimhan, G. Vert, S. Bednarek, J. Friml, Journal of Cell Science 133 (2020)."},"volume":133,"article_processing_charge":"No","has_accepted_license":"1","file":[{"embargo":"2021-08-07","file_name":"2020 - Johnson - JSC - plant CME toolbox.pdf","relation":"main_file","file_size":15150403,"creator":"ajohnson","date_updated":"2021-08-08T22:30:03Z","access_level":"open_access","checksum":"2d11f79a0b4e0a380fb002b933da331a","content_type":"application/pdf","file_id":"8815","date_created":"2020-11-26T17:12:51Z"}],"doi":"10.1242/jcs.248062","issue":"15","abstract":[{"text":"Clathrin-mediated endocytosis (CME) is a crucial cellular process implicated in many aspects of plant growth, development, intra- and inter-cellular signaling, nutrient uptake and pathogen defense. Despite these significant roles, little is known about the precise molecular details of how it functions in planta. In order to facilitate the direct quantitative study of plant CME, here we review current routinely used methods and present refined, standardized quantitative imaging protocols which allow the detailed characterization of CME at multiple scales in plant tissues. These include: (i) an efficient electron microscopy protocol for the imaging of Arabidopsis CME vesicles in situ, thus providing a method for the detailed characterization of the ultra-structure of clathrin-coated vesicles; (ii) a detailed protocol and analysis for quantitative live-cell fluorescence microscopy to precisely examine the temporal interplay of endocytosis components during single CME events; (iii) a semi-automated analysis to allow the quantitative characterization of global internalization of cargos in whole plant tissues; and (iv) an overview and validation of useful genetic and pharmacological tools to interrogate the molecular mechanisms and function of CME in intact plant samples.","lang":"eng"}],"_id":"8139","author":[{"orcid":"0000-0002-2739-8843","first_name":"Alexander J","id":"46A62C3A-F248-11E8-B48F-1D18A9856A87","last_name":"Johnson","full_name":"Johnson, Alexander J"},{"last_name":"Gnyliukh","full_name":"Gnyliukh, Nataliia","first_name":"Nataliia","id":"390C1120-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-2198-0509"},{"full_name":"Kaufmann, Walter","last_name":"Kaufmann","id":"3F99E422-F248-11E8-B48F-1D18A9856A87","first_name":"Walter","orcid":"0000-0001-9735-5315"},{"orcid":"0000-0002-8600-0671","full_name":"Narasimhan, Madhumitha","last_name":"Narasimhan","id":"44BF24D0-F248-11E8-B48F-1D18A9856A87","first_name":"Madhumitha"},{"first_name":"G","last_name":"Vert","full_name":"Vert, G"},{"last_name":"Bednarek","full_name":"Bednarek, SY","first_name":"SY"},{"first_name":"Jiří","id":"4159519E-F248-11E8-B48F-1D18A9856A87","last_name":"Friml","full_name":"Friml, Jiří","orcid":"0000-0002-8302-7596"}],"title":"Experimental toolbox for quantitative evaluation of clathrin-mediated endocytosis in the plant model Arabidopsis","ec_funded":1,"acknowledgement":"This paper is dedicated to the memory of Christien Merrifield. He pioneered quantitative\r\nimaging approaches in mammalian CME and his mentorship inspired the development of all\r\nthe analysis methods presented here. His joy in research, pure scientific curiosity and\r\nmicroscopy excellence remain a constant inspiration. We thank Daniel Van Damme for gifting\r\nus the CLC2-GFP x TPLATE-TagRFP plants used in this manuscript. We further thank the\r\nScientific Service Units at IST Austria; specifically, the Electron Microscopy Facility for\r\ntechnical assistance (in particular Vanessa Zheden) and the BioImaging Facility BioImaging\r\nFacility for access to equipment. ","publication_status":"published","status":"public","project":[{"grant_number":"I03630","_id":"26538374-B435-11E9-9278-68D0E5697425","name":"Molecular mechanisms of endocytic cargo recognition in plants","call_identifier":"FWF"},{"_id":"2564DBCA-B435-11E9-9278-68D0E5697425","grant_number":"665385","name":"International IST Doctoral Program","call_identifier":"H2020"}],"publication_identifier":{"eissn":["1477-9137"],"issn":["0021-9533"]}},{"quality_controlled":"1","language":[{"iso":"eng"}],"type":"journal_article","isi":1,"publisher":"Embo Press","intvolume":"        39","date_created":"2020-07-21T09:08:38Z","acknowledged_ssus":[{"_id":"Bio"},{"_id":"LifeSc"}],"scopus_import":"1","date_published":"2020-09-01T00:00:00Z","external_id":{"isi":["000548311800001"],"pmid":["32667089"]},"user_id":"c635000d-4b10-11ee-a964-aac5a93f6ac1","department":[{"_id":"MiSi"},{"_id":"EvBe"}],"article_number":"e104238","article_type":"original","date_updated":"2023-09-05T13:05:47Z","publication":"The Embo Journal","year":"2020","oa":1,"volume":39,"article_processing_charge":"Yes (via OA deal)","has_accepted_license":"1","file":[{"file_name":"2020_EMBO_Montesinos.pdf","file_size":3497156,"relation":"main_file","creator":"dernst","success":1,"date_updated":"2020-12-02T09:13:23Z","access_level":"open_access","content_type":"application/pdf","checksum":"43d2b36598708e6ab05c69074e191d57","file_id":"8827","date_created":"2020-12-02T09:13:23Z"}],"tmp":{"name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","image":"/images/cc_by.png","short":"CC BY (4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode"},"oa_version":"Published Version","pmid":1,"ddc":["580"],"file_date_updated":"2020-12-02T09:13:23Z","month":"09","citation":{"mla":"Montesinos López, Juan C., et al. “Phytohormone Cytokinin Guides Microtubule Dynamics during Cell Progression from Proliferative to Differentiated Stage.” <i>The Embo Journal</i>, vol. 39, no. 17, e104238, Embo Press, 2020, doi:<a href=\"https://doi.org/10.15252/embj.2019104238\">10.15252/embj.2019104238</a>.","chicago":"Montesinos López, Juan C, A Abuzeineh, Aglaja Kopf, Alba Juanes Garcia, Krisztina Ötvös, J Petrášek, Michael K Sixt, and Eva Benková. “Phytohormone Cytokinin Guides Microtubule Dynamics during Cell Progression from Proliferative to Differentiated Stage.” <i>The Embo Journal</i>. Embo Press, 2020. <a href=\"https://doi.org/10.15252/embj.2019104238\">https://doi.org/10.15252/embj.2019104238</a>.","short":"J.C. Montesinos López, A. Abuzeineh, A. Kopf, A. Juanes Garcia, K. Ötvös, J. Petrášek, M.K. Sixt, E. Benková, The Embo Journal 39 (2020).","ama":"Montesinos López JC, Abuzeineh A, Kopf A, et al. Phytohormone cytokinin guides microtubule dynamics during cell progression from proliferative to differentiated stage. <i>The Embo Journal</i>. 2020;39(17). doi:<a href=\"https://doi.org/10.15252/embj.2019104238\">10.15252/embj.2019104238</a>","ista":"Montesinos López JC, Abuzeineh A, Kopf A, Juanes Garcia A, Ötvös K, Petrášek J, Sixt MK, Benková E. 2020. Phytohormone cytokinin guides microtubule dynamics during cell progression from proliferative to differentiated stage. The Embo Journal. 39(17), e104238.","ieee":"J. C. Montesinos López <i>et al.</i>, “Phytohormone cytokinin guides microtubule dynamics during cell progression from proliferative to differentiated stage,” <i>The Embo Journal</i>, vol. 39, no. 17. Embo Press, 2020.","apa":"Montesinos López, J. C., Abuzeineh, A., Kopf, A., Juanes Garcia, A., Ötvös, K., Petrášek, J., … Benková, E. (2020). Phytohormone cytokinin guides microtubule dynamics during cell progression from proliferative to differentiated stage. <i>The Embo Journal</i>. Embo Press. <a href=\"https://doi.org/10.15252/embj.2019104238\">https://doi.org/10.15252/embj.2019104238</a>"},"day":"01","publication_status":"published","status":"public","acknowledgement":"We thank Takashi Aoyama, David Alabadi, and Bert De Rybel for sharing material, Jiří Friml, Maciek Adamowski, and Katerina Schwarzerová for inspiring discussions, and Martine De Cock for help in preparing the manuscript. This research was supported by the Scientific Service Units (SSUs) of IST Austria through resources provided by the Bioimaging Facility (BIF), especially to Robert Hauschild; and the Life Science Facility (LSF). J.C.M. is the recipient of a EMBO Long‐Term Fellowship (ALTF number 710‐2016). This work was supported with MEYS CR, project no.CZ.02.1.01/0.0/0.0/16_019/0000738 to J.P., and by the Austrian Science Fund (FWF01_I1774S) to E.B.","project":[{"_id":"253E54C8-B435-11E9-9278-68D0E5697425","grant_number":"ALTF710-2016","name":"Molecular mechanism of auxindriven formative divisions delineating lateral root organogenesis in plants"},{"grant_number":"I 1774-B16","_id":"2542D156-B435-11E9-9278-68D0E5697425","name":"Hormone cross-talk drives nutrient dependent plant development","call_identifier":"FWF"}],"publication_identifier":{"issn":["0261-4189"],"eissn":["1460-2075"]},"doi":"10.15252/embj.2019104238","abstract":[{"text":"Cell production and differentiation for the acquisition of specific functions are key features of living systems. The dynamic network of cellular microtubules provides the necessary platform to accommodate processes associated with the transition of cells through the individual phases of cytogenesis. Here, we show that the plant hormone cytokinin fine‐tunes the activity of the microtubular cytoskeleton during cell differentiation and counteracts microtubular rearrangements driven by the hormone auxin. The endogenous upward gradient of cytokinin activity along the longitudinal growth axis in Arabidopsis thaliana roots correlates with robust rearrangements of the microtubule cytoskeleton in epidermal cells progressing from the proliferative to the differentiation stage. Controlled increases in cytokinin activity result in premature re‐organization of the microtubule network from transversal to an oblique disposition in cells prior to their differentiation, whereas attenuated hormone perception delays cytoskeleton conversion into a configuration typical for differentiated cells. Intriguingly, cytokinin can interfere with microtubules also in animal cells, such as leukocytes, suggesting that a cytokinin‐sensitive control pathway for the microtubular cytoskeleton may be at least partially conserved between plant and animal cells.","lang":"eng"}],"issue":"17","_id":"8142","title":"Phytohormone cytokinin guides microtubule dynamics during cell progression from proliferative to differentiated stage","author":[{"full_name":"Montesinos López, Juan C","last_name":"Montesinos López","id":"310A8E3E-F248-11E8-B48F-1D18A9856A87","first_name":"Juan C","orcid":"0000-0001-9179-6099"},{"first_name":"A","full_name":"Abuzeineh, A","last_name":"Abuzeineh"},{"id":"31DAC7B6-F248-11E8-B48F-1D18A9856A87","first_name":"Aglaja","full_name":"Kopf, Aglaja","last_name":"Kopf","orcid":"0000-0002-2187-6656"},{"orcid":"0000-0002-1009-9652","id":"40F05888-F248-11E8-B48F-1D18A9856A87","first_name":"Alba","full_name":"Juanes Garcia, Alba","last_name":"Juanes Garcia"},{"first_name":"Krisztina","id":"29B901B0-F248-11E8-B48F-1D18A9856A87","last_name":"Ötvös","full_name":"Ötvös, Krisztina","orcid":"0000-0002-5503-4983"},{"full_name":"Petrášek, J","last_name":"Petrášek","first_name":"J"},{"orcid":"0000-0002-6620-9179","first_name":"Michael K","id":"41E9FBEA-F248-11E8-B48F-1D18A9856A87","last_name":"Sixt","full_name":"Sixt, Michael K"},{"orcid":"0000-0002-8510-9739","id":"38F4F166-F248-11E8-B48F-1D18A9856A87","first_name":"Eva","full_name":"Benková, Eva","last_name":"Benková"}]},{"page":"310","related_material":{"record":[{"relation":"part_of_dissertation","status":"public","id":"7675"},{"id":"7569","status":"public","relation":"part_of_dissertation"},{"status":"public","relation":"part_of_dissertation","id":"7652"}]},"date_updated":"2023-09-07T13:13:27Z","alternative_title":["ISTA Thesis"],"year":"2020","oa":1,"type":"dissertation","language":[{"iso":"eng"}],"publisher":"Institute of Science and Technology Austria","date_created":"2020-07-23T09:51:28Z","date_published":"2020-07-24T00:00:00Z","user_id":"c635000d-4b10-11ee-a964-aac5a93f6ac1","department":[{"_id":"CaGu"},{"_id":"GaTk"}],"acknowledgement":"For the duration of his PhD, Rok was a recipient of a DOC fellowship of the Austrian Academy of Sciences.","publication_status":"published","status":"public","project":[{"name":"Biophysically realistic genotype-phenotype maps for regulatory networks","_id":"267C84F4-B435-11E9-9278-68D0E5697425"}],"publication_identifier":{"issn":["2663-337X"]},"doi":"10.15479/AT:ISTA:8155","abstract":[{"text":"In the thesis we focus on the interplay of the biophysics and evolution of gene regulation. We start by addressing how the type of prokaryotic gene regulation – activation and repression – affects spurious binding to DNA, also known as\r\ntranscriptional crosstalk. We propose that regulatory interference caused by excess regulatory proteins in the dense cellular medium – global crosstalk – could be a factor in determining which type of gene regulatory network is evolutionarily preferred. Next,we use a normative approach in eukaryotic gene regulation to describe minimal\r\nnon-equilibrium enhancer models that optimize so-called regulatory phenotypes. We find a class of models that differ from standard thermodynamic equilibrium models by a single parameter that notably increases the regulatory performance. Next chapter addresses the question of genotype-phenotype-fitness maps of higher dimensional phenotypes. We show that our biophysically realistic approach allows us to understand how the mechanisms of promoter function constrain genotypephenotype maps, and how they affect the evolutionary trajectories of promoters.\r\nIn the last chapter we ask whether the intrinsic instability of gene duplication and amplification provides a generic alternative to canonical gene regulation. Using mathematical modeling, we show that amplifications can tune gene expression in many environments, including those where transcription factor-based schemes are\r\nhard to evolve or maintain. ","lang":"eng"}],"_id":"8155","supervisor":[{"last_name":"Guet","full_name":"Guet, Calin C","first_name":"Calin C","id":"47F8433E-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0001-6220-2052"},{"first_name":"Gašper","id":"3D494DCA-F248-11E8-B48F-1D18A9856A87","last_name":"Tkačik","full_name":"Tkačik, Gašper","orcid":"0000-0002-6699-1455"}],"title":"Gene regulation across scales – how biophysical constraints shape evolution","author":[{"first_name":"Rok","id":"483E70DE-F248-11E8-B48F-1D18A9856A87","last_name":"Grah","full_name":"Grah, Rok","orcid":"0000-0003-2539-3560"}],"article_processing_charge":"No","has_accepted_license":"1","file":[{"success":1,"date_updated":"2020-07-27T12:00:07Z","access_level":"open_access","content_type":"application/pdf","file_name":"Thesis_RokGrah_200727_convertedNew.pdf","relation":"main_file","file_size":16638998,"creator":"rgrah","file_id":"8176","date_created":"2020-07-27T12:00:07Z"},{"date_updated":"2020-07-30T13:04:55Z","access_level":"closed","content_type":"application/zip","file_name":"Thesis_new.zip","file_size":347459978,"relation":"main_file","creator":"rgrah","file_id":"8177","date_created":"2020-07-27T12:02:23Z"}],"degree_awarded":"PhD","oa_version":"Published Version","file_date_updated":"2020-07-30T13:04:55Z","ddc":["530","570"],"month":"07","citation":{"ama":"Grah R. Gene regulation across scales – how biophysical constraints shape evolution. 2020. doi:<a href=\"https://doi.org/10.15479/AT:ISTA:8155\">10.15479/AT:ISTA:8155</a>","short":"R. Grah, Gene Regulation across Scales – How Biophysical Constraints Shape Evolution, Institute of Science and Technology Austria, 2020.","ista":"Grah R. 2020. Gene regulation across scales – how biophysical constraints shape evolution. Institute of Science and Technology Austria.","apa":"Grah, R. (2020). <i>Gene regulation across scales – how biophysical constraints shape evolution</i>. Institute of Science and Technology Austria. <a href=\"https://doi.org/10.15479/AT:ISTA:8155\">https://doi.org/10.15479/AT:ISTA:8155</a>","ieee":"R. Grah, “Gene regulation across scales – how biophysical constraints shape evolution,” Institute of Science and Technology Austria, 2020.","chicago":"Grah, Rok. “Gene Regulation across Scales – How Biophysical Constraints Shape Evolution.” Institute of Science and Technology Austria, 2020. <a href=\"https://doi.org/10.15479/AT:ISTA:8155\">https://doi.org/10.15479/AT:ISTA:8155</a>.","mla":"Grah, Rok. <i>Gene Regulation across Scales – How Biophysical Constraints Shape Evolution</i>. Institute of Science and Technology Austria, 2020, doi:<a href=\"https://doi.org/10.15479/AT:ISTA:8155\">10.15479/AT:ISTA:8155</a>."},"day":"24"},{"department":[{"_id":"UlWa"}],"user_id":"c635000d-4b10-11ee-a964-aac5a93f6ac1","date_published":"2020-07-24T00:00:00Z","date_created":"2020-07-23T09:51:29Z","publisher":"Institute of Science and Technology Austria","type":"dissertation","language":[{"iso":"eng"}],"oa":1,"alternative_title":["ISTA Thesis"],"year":"2020","date_updated":"2023-12-18T10:51:01Z","related_material":{"record":[{"id":"8182","relation":"part_of_dissertation","status":"public"},{"id":"8183","relation":"part_of_dissertation","status":"public"},{"status":"public","relation":"part_of_dissertation","id":"8185"},{"status":"public","relation":"part_of_dissertation","id":"8184"},{"relation":"part_of_dissertation","status":"public","id":"6355"},{"id":"75","status":"public","relation":"part_of_dissertation"}]},"page":"119","day":"24","citation":{"ama":"Avvakumov S. Topological methods in geometry and discrete mathematics. 2020. doi:<a href=\"https://doi.org/10.15479/AT:ISTA:8156\">10.15479/AT:ISTA:8156</a>","short":"S. Avvakumov, Topological Methods in Geometry and Discrete Mathematics, Institute of Science and Technology Austria, 2020.","ista":"Avvakumov S. 2020. Topological methods in geometry and discrete mathematics. Institute of Science and Technology Austria.","apa":"Avvakumov, S. (2020). <i>Topological methods in geometry and discrete mathematics</i>. Institute of Science and Technology Austria. <a href=\"https://doi.org/10.15479/AT:ISTA:8156\">https://doi.org/10.15479/AT:ISTA:8156</a>","ieee":"S. Avvakumov, “Topological methods in geometry and discrete mathematics,” Institute of Science and Technology Austria, 2020.","mla":"Avvakumov, Sergey. <i>Topological Methods in Geometry and Discrete Mathematics</i>. Institute of Science and Technology Austria, 2020, doi:<a href=\"https://doi.org/10.15479/AT:ISTA:8156\">10.15479/AT:ISTA:8156</a>.","chicago":"Avvakumov, Sergey. “Topological Methods in Geometry and Discrete Mathematics.” Institute of Science and Technology Austria, 2020. <a href=\"https://doi.org/10.15479/AT:ISTA:8156\">https://doi.org/10.15479/AT:ISTA:8156</a>."},"file_date_updated":"2020-07-27T12:46:53Z","month":"07","ddc":["514"],"oa_version":"Published Version","degree_awarded":"PhD","file":[{"date_created":"2020-07-27T12:44:51Z","file_id":"8178","date_updated":"2020-07-27T12:44:51Z","content_type":"application/zip","access_level":"closed","file_size":1061740,"relation":"source_file","creator":"savvakum","file_name":"source.zip"},{"access_level":"open_access","content_type":"application/pdf","success":1,"date_updated":"2020-07-27T12:46:53Z","file_name":"thesis_pdfa.pdf","creator":"savvakum","relation":"main_file","file_size":1336501,"file_id":"8179","date_created":"2020-07-27T12:46:53Z"}],"has_accepted_license":"1","article_processing_charge":"No","author":[{"first_name":"Sergey","id":"3827DAC8-F248-11E8-B48F-1D18A9856A87","last_name":"Avvakumov","full_name":"Avvakumov, Sergey"}],"title":"Topological methods in geometry and discrete mathematics","supervisor":[{"orcid":"0000-0002-1494-0568","first_name":"Uli","id":"36690CA2-F248-11E8-B48F-1D18A9856A87","last_name":"Wagner","full_name":"Wagner, Uli"}],"_id":"8156","abstract":[{"lang":"eng","text":"We present solutions to several problems originating from geometry and discrete mathematics: existence of equipartitions, maps without Tverberg multiple points, and inscribing quadrilaterals. Equivariant obstruction theory is the natural topological approach to these type of questions. However, for the specific problems we consider it had yielded only partial or no results. We get our results by complementing equivariant obstruction theory with other techniques from topology and geometry."}],"doi":"10.15479/AT:ISTA:8156","publication_identifier":{"issn":["2663-337X"]},"status":"public","publication_status":"published"},{"isi":1,"type":"journal_article","language":[{"iso":"eng"}],"quality_controlled":"1","publisher":"Elsevier","intvolume":"       107","date_published":"2020-09-23T00:00:00Z","external_id":{"isi":["000579698700006"]},"date_created":"2020-07-23T16:03:12Z","acknowledged_ssus":[{"_id":"Bio"},{"_id":"LifeSc"},{"_id":"PreCl"}],"scopus_import":"1","department":[{"_id":"SiHi"}],"user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","related_material":{"link":[{"relation":"press_release","url":"https://ist.ac.at/en/news/cells-react-differently-to-genomic-imprinting/","description":"News on IST Website"}]},"page":"1160-1179.e9","article_type":"original","publication":"Neuron","date_updated":"2023-08-22T08:20:11Z","year":"2020","oa":1,"has_accepted_license":"1","article_processing_charge":"No","volume":107,"tmp":{"name":"Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)","image":"/images/cc_by_nc_nd.png","short":"CC BY-NC-ND (4.0)","legal_code_url":"https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode"},"file":[{"date_created":"2020-12-02T09:26:46Z","file_id":"8828","relation":"main_file","creator":"dernst","file_size":8911830,"file_name":"2020_Neuron_Laukoter.pdf","date_updated":"2020-12-02T09:26:46Z","success":1,"checksum":"7becdc16a6317304304631087ae7dd7f","content_type":"application/pdf","access_level":"open_access"}],"oa_version":"Published Version","citation":{"apa":"Laukoter, S., Pauler, F., Beattie, R. J., Amberg, N., Hansen, A. H., Streicher, C., … Hippenmeyer, S. (2020). Cell-type specificity of genomic imprinting in cerebral cortex. <i>Neuron</i>. Elsevier. <a href=\"https://doi.org/10.1016/j.neuron.2020.06.031\">https://doi.org/10.1016/j.neuron.2020.06.031</a>","ieee":"S. Laukoter <i>et al.</i>, “Cell-type specificity of genomic imprinting in cerebral cortex,” <i>Neuron</i>, vol. 107, no. 6. Elsevier, p. 1160–1179.e9, 2020.","short":"S. Laukoter, F. Pauler, R.J. Beattie, N. Amberg, A.H. Hansen, C. Streicher, T. Penz, C. Bock, S. Hippenmeyer, Neuron 107 (2020) 1160–1179.e9.","ama":"Laukoter S, Pauler F, Beattie RJ, et al. Cell-type specificity of genomic imprinting in cerebral cortex. <i>Neuron</i>. 2020;107(6):1160-1179.e9. doi:<a href=\"https://doi.org/10.1016/j.neuron.2020.06.031\">10.1016/j.neuron.2020.06.031</a>","ista":"Laukoter S, Pauler F, Beattie RJ, Amberg N, Hansen AH, Streicher C, Penz T, Bock C, Hippenmeyer S. 2020. Cell-type specificity of genomic imprinting in cerebral cortex. Neuron. 107(6), 1160–1179.e9.","mla":"Laukoter, Susanne, et al. “Cell-Type Specificity of Genomic Imprinting in Cerebral Cortex.” <i>Neuron</i>, vol. 107, no. 6, Elsevier, 2020, p. 1160–1179.e9, doi:<a href=\"https://doi.org/10.1016/j.neuron.2020.06.031\">10.1016/j.neuron.2020.06.031</a>.","chicago":"Laukoter, Susanne, Florian Pauler, Robert J Beattie, Nicole Amberg, Andi H Hansen, Carmen Streicher, Thomas Penz, Christoph Bock, and Simon Hippenmeyer. “Cell-Type Specificity of Genomic Imprinting in Cerebral Cortex.” <i>Neuron</i>. Elsevier, 2020. <a href=\"https://doi.org/10.1016/j.neuron.2020.06.031\">https://doi.org/10.1016/j.neuron.2020.06.031</a>."},"day":"23","file_date_updated":"2020-12-02T09:26:46Z","ddc":["570"],"month":"09","acknowledgement":"We thank A. Heger (IST Austria Preclinical Facility), A. Sommer and C. Czepe (VBCF GmbH, NGS Unit), and A. Seitz and P. Moll (Lexogen GmbH) for technical support; G. Arque, S. Resch, C. Igler, C. Dotter, C. Yahya, Q. Hudson, and D. Andergassen for initial experiments and/or assistance; D. Barlow, O. Bell, and all members of the Hippenmeyer lab for discussion; and N. Barton, B. Vicoso, M. Sixt, and L. Luo for comments on earlier versions of the manuscript. This research was supported by the Scientific Service Units (SSU) of IST Austria through resources provided by the Bioimaging Facilities (BIF), Life Science Facilities (LSF), and Preclinical Facilities (PCF). A.H.H. is a recipient of a DOC fellowship (24812) of the Austrian Academy of Sciences. N.A. received support from the FWF Firnberg-Programm (T 1031). R.B. received support from the FWF Meitner-Programm (M 2416). This work was also supported by IST Austria institutional funds; a NÖ Forschung und Bildung n[f+b] life science call grant (C13-002) to S.H.; a program grant from the Human Frontiers Science Program (RGP0053/2014) to S.H.; the People Programme (Marie Curie Actions) of the European Union’s Seventh Framework Programme (FP7/2007-2013) under REA grant agreement 618444 to S.H.; and the European Research Council (ERC) under the European Union’s Horizon 2020 research and innovation program (grant agreement 725780 LinPro) to S.H.","publication_status":"published","status":"public","ec_funded":1,"publication_identifier":{"issn":["0896-6273"]},"project":[{"name":"Molecular Mechanisms of Radial Neuronal Migration","grant_number":"24812","_id":"2625A13E-B435-11E9-9278-68D0E5697425"},{"_id":"268F8446-B435-11E9-9278-68D0E5697425","grant_number":"T0101031","name":"Role of Eed in neural stem cell lineage progression","call_identifier":"FWF"},{"name":"Molecular Mechanisms Regulating Gliogenesis in the Cerebral Cortex","call_identifier":"FWF","grant_number":"M02416","_id":"264E56E2-B435-11E9-9278-68D0E5697425"},{"name":"Mapping Cell-Type Specificity of the Genomic Imprintome in the Brain","grant_number":"LS13-002","_id":"25D92700-B435-11E9-9278-68D0E5697425"},{"grant_number":"RGP0053/2014","_id":"25D7962E-B435-11E9-9278-68D0E5697425","name":"Quantitative Structure-Function Analysis of Cerebral Cortex Assembly at Clonal Level"},{"call_identifier":"FP7","name":"Molecular Mechanisms of Cerebral Cortex Development","_id":"25D61E48-B435-11E9-9278-68D0E5697425","grant_number":"618444"},{"_id":"260018B0-B435-11E9-9278-68D0E5697425","grant_number":"725780","name":"Principles of Neural Stem Cell Lineage Progression in Cerebral Cortex Development","call_identifier":"H2020"}],"abstract":[{"lang":"eng","text":"In mammalian genomes, a subset of genes is regulated by genomic imprinting, resulting in silencing of one parental allele. Imprinting is essential for cerebral cortex development, but prevalence and functional impact in individual cells is unclear. Here, we determined allelic expression in cortical cell types and established a quantitative platform to interrogate imprinting in single cells. We created cells with uniparental chromosome disomy (UPD) containing two copies of either the maternal or the paternal chromosome; hence, imprinted genes will be 2-fold overexpressed or not expressed. By genetic labeling of UPD, we determined cellular phenotypes and transcriptional responses to deregulated imprinted gene expression at unprecedented single-cell resolution. We discovered an unexpected degree of cell-type specificity and a novel function of imprinting in the regulation of cortical astrocyte survival. More generally, our results suggest functional relevance of imprinted gene expression in glial astrocyte lineage and thus for generating cortical cell-type diversity."}],"issue":"6","doi":"10.1016/j.neuron.2020.06.031","title":"Cell-type specificity of genomic imprinting in cerebral cortex","author":[{"first_name":"Susanne","id":"2D6B7A9A-F248-11E8-B48F-1D18A9856A87","last_name":"Laukoter","full_name":"Laukoter, Susanne","orcid":"0000-0002-7903-3010"},{"orcid":"0000-0002-7462-0048","first_name":"Florian","id":"48EA0138-F248-11E8-B48F-1D18A9856A87","last_name":"Pauler","full_name":"Pauler, Florian"},{"last_name":"Beattie","full_name":"Beattie, Robert J","first_name":"Robert J","id":"2E26DF60-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-8483-8753"},{"full_name":"Amberg, Nicole","last_name":"Amberg","id":"4CD6AAC6-F248-11E8-B48F-1D18A9856A87","first_name":"Nicole","orcid":"0000-0002-3183-8207"},{"id":"38853E16-F248-11E8-B48F-1D18A9856A87","first_name":"Andi H","full_name":"Hansen, Andi H","last_name":"Hansen"},{"full_name":"Streicher, Carmen","last_name":"Streicher","id":"36BCB99C-F248-11E8-B48F-1D18A9856A87","first_name":"Carmen"},{"first_name":"Thomas","full_name":"Penz, Thomas","last_name":"Penz"},{"orcid":"0000-0001-6091-3088","first_name":"Christoph","last_name":"Bock","full_name":"Bock, Christoph"},{"full_name":"Hippenmeyer, Simon","last_name":"Hippenmeyer","id":"37B36620-F248-11E8-B48F-1D18A9856A87","first_name":"Simon","orcid":"0000-0003-2279-1061"}],"_id":"8162"},{"year":"2020","oa":1,"page":"193-199","article_type":"original","date_updated":"2023-10-10T13:05:27Z","publication":"Studia Scientiarum Mathematicarum Hungarica","date_created":"2020-07-24T07:09:18Z","scopus_import":"1","external_id":{"isi":["000570978400005"]},"date_published":"2020-07-24T00:00:00Z","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","department":[{"_id":"HeEd"}],"quality_controlled":"1","type":"journal_article","language":[{"iso":"eng"}],"isi":1,"publisher":"Akadémiai Kiadó","intvolume":"        57","doi":"10.1556/012.2020.57.2.1454","abstract":[{"text":"Fejes Tóth [3] studied approximations of smooth surfaces in three-space by piecewise flat triangular meshes with a given number of vertices on the surface that are optimal with respect to Hausdorff distance. He proves that this Hausdorff distance decreases inversely proportional with the number of vertices of the approximating mesh if the surface is convex. He also claims that this Hausdorff distance is inversely proportional to the square of the number of vertices for a specific non-convex surface, namely a one-sheeted hyperboloid of revolution bounded by two congruent circles. We refute this claim, and show that the asymptotic behavior of the Hausdorff distance is linear, that is the same as for convex surfaces.","lang":"eng"}],"issue":"2","_id":"8163","title":"Refutation of a claim made by Fejes Tóth on the accuracy of surface meshes","author":[{"first_name":"Gert","last_name":"Vegter","full_name":"Vegter, Gert"},{"full_name":"Wintraecken, Mathijs","last_name":"Wintraecken","id":"307CFBC8-F248-11E8-B48F-1D18A9856A87","first_name":"Mathijs","orcid":"0000-0002-7472-2220"}],"ec_funded":1,"publication_status":"published","status":"public","acknowledgement":"The authors are greatly indebted to Dror Atariah, Günther Rote and John Sullivan for discussion and suggestions. The authors also thank Jean-Daniel Boissonnat, Ramsay Dyer, David de Laat and Rien van de Weijgaert for discussion. This work has been supported in part by the European Union’s Seventh Framework Programme for Research of the\r\nEuropean Commission, under FET-Open grant number 255827 (CGL Computational Geometry Learning) and ERC Grant Agreement number 339025 GUDHI (Algorithmic Foundations of Geometry Understanding in Higher Dimensions), the European Union’s Horizon 2020 research and innovation programme under the Marie Sk lodowska-Curie grant agreement number 754411,and the Austrian Science Fund (FWF): Z00342 N31.","project":[{"name":"ISTplus - Postdoctoral Fellowships","call_identifier":"H2020","_id":"260C2330-B435-11E9-9278-68D0E5697425","grant_number":"754411"},{"call_identifier":"FWF","name":"The Wittgenstein Prize","_id":"268116B8-B435-11E9-9278-68D0E5697425","grant_number":"Z00342"}],"publication_identifier":{"eissn":["1588-2896"],"issn":["0081-6906"]},"oa_version":"Published Version","license":"https://creativecommons.org/licenses/by-nc/4.0/","ddc":["510"],"month":"07","file_date_updated":"2020-07-24T07:09:06Z","citation":{"ieee":"G. Vegter and M. Wintraecken, “Refutation of a claim made by Fejes Tóth on the accuracy of surface meshes,” <i>Studia Scientiarum Mathematicarum Hungarica</i>, vol. 57, no. 2. Akadémiai Kiadó, pp. 193–199, 2020.","apa":"Vegter, G., &#38; Wintraecken, M. (2020). Refutation of a claim made by Fejes Tóth on the accuracy of surface meshes. <i>Studia Scientiarum Mathematicarum Hungarica</i>. Akadémiai Kiadó. <a href=\"https://doi.org/10.1556/012.2020.57.2.1454\">https://doi.org/10.1556/012.2020.57.2.1454</a>","ama":"Vegter G, Wintraecken M. Refutation of a claim made by Fejes Tóth on the accuracy of surface meshes. <i>Studia Scientiarum Mathematicarum Hungarica</i>. 2020;57(2):193-199. doi:<a href=\"https://doi.org/10.1556/012.2020.57.2.1454\">10.1556/012.2020.57.2.1454</a>","short":"G. Vegter, M. Wintraecken, Studia Scientiarum Mathematicarum Hungarica 57 (2020) 193–199.","ista":"Vegter G, Wintraecken M. 2020. Refutation of a claim made by Fejes Tóth on the accuracy of surface meshes. Studia Scientiarum Mathematicarum Hungarica. 57(2), 193–199.","mla":"Vegter, Gert, and Mathijs Wintraecken. “Refutation of a Claim Made by Fejes Tóth on the Accuracy of Surface Meshes.” <i>Studia Scientiarum Mathematicarum Hungarica</i>, vol. 57, no. 2, Akadémiai Kiadó, 2020, pp. 193–99, doi:<a href=\"https://doi.org/10.1556/012.2020.57.2.1454\">10.1556/012.2020.57.2.1454</a>.","chicago":"Vegter, Gert, and Mathijs Wintraecken. “Refutation of a Claim Made by Fejes Tóth on the Accuracy of Surface Meshes.” <i>Studia Scientiarum Mathematicarum Hungarica</i>. Akadémiai Kiadó, 2020. <a href=\"https://doi.org/10.1556/012.2020.57.2.1454\">https://doi.org/10.1556/012.2020.57.2.1454</a>."},"day":"24","article_processing_charge":"No","volume":57,"has_accepted_license":"1","file":[{"date_updated":"2020-07-24T07:09:06Z","access_level":"open_access","content_type":"application/pdf","file_name":"57-2-05_4214-1454Vegter-Wintraecken_OpenAccess_CC-BY-NC.pdf","creator":"mwintrae","file_size":1476072,"relation":"main_file","file_id":"8164","date_created":"2020-07-24T07:09:06Z"}],"tmp":{"short":"CC BY-NC (4.0)","legal_code_url":"https://creativecommons.org/licenses/by-nc/4.0/legalcode","image":"/images/cc_by_nc.png","name":"Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0)"}},{"oa":1,"year":"2020","publication":"Philosophical Transactions of the Royal Society. Series B: Biological Sciences","date_updated":"2023-08-22T08:22:13Z","article_type":"original","article_number":"20190545","department":[{"_id":"NiBa"}],"user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","date_published":"2020-07-12T00:00:00Z","external_id":{"isi":["000552662100014"],"pmid":["32654639"]},"scopus_import":"1","date_created":"2020-07-26T22:01:01Z","main_file_link":[{"url":"https://doi.org/10.1098/rstb.2019.0545","open_access":"1"}],"intvolume":"       375","publisher":"The Royal Society","isi":1,"quality_controlled":"1","type":"journal_article","language":[{"iso":"eng"}],"author":[{"last_name":"Stankowski","full_name":"Stankowski, Sean","first_name":"Sean","id":"43161670-5719-11EA-8025-FABC3DDC885E"},{"orcid":"0000-0003-1050-4969","full_name":"Westram, Anja M","last_name":"Westram","id":"3C147470-F248-11E8-B48F-1D18A9856A87","first_name":"Anja M"},{"first_name":"Zuzanna B.","last_name":"Zagrodzka","full_name":"Zagrodzka, Zuzanna B."},{"last_name":"Eyres","full_name":"Eyres, Isobel","first_name":"Isobel"},{"full_name":"Broquet, Thomas","last_name":"Broquet","first_name":"Thomas"},{"last_name":"Johannesson","full_name":"Johannesson, Kerstin","first_name":"Kerstin"},{"full_name":"Butlin, Roger K.","last_name":"Butlin","first_name":"Roger K."}],"title":"The evolution of strong reproductive isolation between sympatric intertidal snails","_id":"8167","issue":"1806","abstract":[{"lang":"eng","text":"The evolution of strong reproductive isolation (RI) is fundamental to the origins and maintenance of biological diversity, especially in situations where geographical distributions of taxa broadly overlap. But what is the history behind strong barriers currently acting in sympatry? Using whole-genome sequencing and single nucleotide polymorphism genotyping, we inferred (i) the evolutionary relationships, (ii) the strength of RI, and (iii) the demographic history of divergence between two broadly sympatric taxa of intertidal snail. Despite being cryptic, based on external morphology, Littorina arcana and Littorina saxatilis differ in their mode of female reproduction (egg-laying versus brooding), which may generate a strong post-zygotic barrier. We show that egg-laying and brooding snails are closely related, but genetically distinct. Genotyping of 3092 snails from three locations failed to recover any recent hybrid or backcrossed individuals, confirming that RI is strong. There was, however, evidence for a very low level of asymmetrical introgression, suggesting that isolation remains incomplete. The presence of strong, asymmetrical RI was further supported by demographic analysis of these populations. Although the taxa are currently broadly sympatric, demographic modelling suggests that they initially diverged during a short period of geographical separation involving very low gene flow. Our study suggests that some geographical separation may kick-start the evolution of strong RI, facilitating subsequent coexistence of taxa in sympatry. The strength of RI needed to achieve sympatry and the subsequent effect of sympatry on RI remain open questions."}],"doi":"10.1098/rstb.2019.0545","publication_identifier":{"eissn":["1471-2970"]},"acknowledgement":"Funding was provided by the Natural Environment Research Council (NERC) and the European Research Council. We thank Rui Faria, Nicola Nadeau, Martin Garlovsky and Hernan Morales for advice and/or useful discussion during the project. Richard Turney, Graciela Sotelo, Jenny Larson, Stéphane Loisel and Meghan Wharton participated in the collection and processing of samples. Mark Dunning helped with the development of bioinformatic pipelines. The analysis of genomic data was conducted on the University of Sheffield High-performance computer, ShARC. Jeffrey Feder and an anonymous reviewer provided comments that improved the manuscript.","status":"public","publication_status":"published","day":"12","citation":{"short":"S. Stankowski, A.M. Westram, Z.B. Zagrodzka, I. Eyres, T. Broquet, K. Johannesson, R.K. Butlin, Philosophical Transactions of the Royal Society. Series B: Biological Sciences 375 (2020).","ama":"Stankowski S, Westram AM, Zagrodzka ZB, et al. The evolution of strong reproductive isolation between sympatric intertidal snails. <i>Philosophical Transactions of the Royal Society Series B: Biological Sciences</i>. 2020;375(1806). doi:<a href=\"https://doi.org/10.1098/rstb.2019.0545\">10.1098/rstb.2019.0545</a>","ista":"Stankowski S, Westram AM, Zagrodzka ZB, Eyres I, Broquet T, Johannesson K, Butlin RK. 2020. The evolution of strong reproductive isolation between sympatric intertidal snails. Philosophical Transactions of the Royal Society. Series B: Biological Sciences. 375(1806), 20190545.","ieee":"S. Stankowski <i>et al.</i>, “The evolution of strong reproductive isolation between sympatric intertidal snails,” <i>Philosophical Transactions of the Royal Society. Series B: Biological Sciences</i>, vol. 375, no. 1806. The Royal Society, 2020.","apa":"Stankowski, S., Westram, A. M., Zagrodzka, Z. B., Eyres, I., Broquet, T., Johannesson, K., &#38; Butlin, R. K. (2020). The evolution of strong reproductive isolation between sympatric intertidal snails. <i>Philosophical Transactions of the Royal Society. Series B: Biological Sciences</i>. The Royal Society. <a href=\"https://doi.org/10.1098/rstb.2019.0545\">https://doi.org/10.1098/rstb.2019.0545</a>","mla":"Stankowski, Sean, et al. “The Evolution of Strong Reproductive Isolation between Sympatric Intertidal Snails.” <i>Philosophical Transactions of the Royal Society. Series B: Biological Sciences</i>, vol. 375, no. 1806, 20190545, The Royal Society, 2020, doi:<a href=\"https://doi.org/10.1098/rstb.2019.0545\">10.1098/rstb.2019.0545</a>.","chicago":"Stankowski, Sean, Anja M Westram, Zuzanna B. Zagrodzka, Isobel Eyres, Thomas Broquet, Kerstin Johannesson, and Roger K. Butlin. “The Evolution of Strong Reproductive Isolation between Sympatric Intertidal Snails.” <i>Philosophical Transactions of the Royal Society. Series B: Biological Sciences</i>. The Royal Society, 2020. <a href=\"https://doi.org/10.1098/rstb.2019.0545\">https://doi.org/10.1098/rstb.2019.0545</a>."},"pmid":1,"month":"07","oa_version":"Published Version","article_processing_charge":"No","volume":375},{"status":"public","publication_status":"published","ec_funded":1,"publication_identifier":{"eissn":["1471-2970"],"issn":["0962-8436"]},"project":[{"name":"Theoretical and empirical approaches to understanding Parallel Adaptation","call_identifier":"H2020","grant_number":"797747","_id":"265B41B8-B435-11E9-9278-68D0E5697425"}],"abstract":[{"lang":"eng","text":"Speciation, that is, the evolution of reproductive barriers eventually leading to complete isolation, is a crucial process generating biodiversity. Recent work has contributed much to our understanding of how reproductive barriers begin to evolve, and how they are maintained in the face of gene flow. However, little is known about the transition from partial to strong reproductive isolation (RI) and the completion of speciation. We argue that the evolution of strong RI is likely to involve different processes, or new interactions among processes, compared with the evolution of the first reproductive barriers. Transition to strong RI may be brought about by changing external conditions, for example, following secondary contact. However, the increasing levels of RI themselves create opportunities for new barriers to evolve and, and interaction or coupling among barriers. These changing processes may depend on genomic architecture and leave detectable signals in the genome. We outline outstanding questions and suggest more theoretical and empirical work, considering both patterns and processes associated with strong RI, is needed to understand how speciation is completed."}],"issue":"1806","doi":"10.1098/rstb.2019.0528","title":"Towards the completion of speciation: The evolution of reproductive isolation beyond the first barriers","author":[{"first_name":"Jonna","last_name":"Kulmuni","full_name":"Kulmuni, Jonna"},{"full_name":"Butlin, Roger K.","last_name":"Butlin","first_name":"Roger K."},{"full_name":"Lucek, Kay","last_name":"Lucek","first_name":"Kay"},{"last_name":"Savolainen","full_name":"Savolainen, Vincent","first_name":"Vincent"},{"orcid":"0000-0003-1050-4969","last_name":"Westram","full_name":"Westram, Anja M","first_name":"Anja M","id":"3C147470-F248-11E8-B48F-1D18A9856A87"}],"_id":"8168","volume":375,"article_processing_charge":"No","oa_version":"Published Version","citation":{"mla":"Kulmuni, Jonna, et al. “Towards the Completion of Speciation: The Evolution of Reproductive Isolation beyond the First Barriers.” <i>Philosophical Transactions of the Royal Society. Series B: Biological Sciences</i>, vol. 375, no. 1806, 20190528, The Royal Society, 2020, doi:<a href=\"https://doi.org/10.1098/rstb.2019.0528\">10.1098/rstb.2019.0528</a>.","chicago":"Kulmuni, Jonna, Roger K. Butlin, Kay Lucek, Vincent Savolainen, and Anja M Westram. “Towards the Completion of Speciation: The Evolution of Reproductive Isolation beyond the First Barriers.” <i>Philosophical Transactions of the Royal Society. Series B: Biological Sciences</i>. The Royal Society, 2020. <a href=\"https://doi.org/10.1098/rstb.2019.0528\">https://doi.org/10.1098/rstb.2019.0528</a>.","ista":"Kulmuni J, Butlin RK, Lucek K, Savolainen V, Westram AM. 2020. Towards the completion of speciation: The evolution of reproductive isolation beyond the first barriers. Philosophical Transactions of the Royal Society. Series B: Biological sciences. 375(1806), 20190528.","ama":"Kulmuni J, Butlin RK, Lucek K, Savolainen V, Westram AM. Towards the completion of speciation: The evolution of reproductive isolation beyond the first barriers. <i>Philosophical Transactions of the Royal Society Series B: Biological sciences</i>. 2020;375(1806). doi:<a href=\"https://doi.org/10.1098/rstb.2019.0528\">10.1098/rstb.2019.0528</a>","short":"J. Kulmuni, R.K. Butlin, K. Lucek, V. Savolainen, A.M. Westram, Philosophical Transactions of the Royal Society. Series B: Biological Sciences 375 (2020).","ieee":"J. Kulmuni, R. K. Butlin, K. Lucek, V. Savolainen, and A. M. Westram, “Towards the completion of speciation: The evolution of reproductive isolation beyond the first barriers,” <i>Philosophical Transactions of the Royal Society. Series B: Biological sciences</i>, vol. 375, no. 1806. The Royal Society, 2020.","apa":"Kulmuni, J., Butlin, R. K., Lucek, K., Savolainen, V., &#38; Westram, A. M. (2020). Towards the completion of speciation: The evolution of reproductive isolation beyond the first barriers. <i>Philosophical Transactions of the Royal Society. Series B: Biological Sciences</i>. The Royal Society. <a href=\"https://doi.org/10.1098/rstb.2019.0528\">https://doi.org/10.1098/rstb.2019.0528</a>"},"day":"12","month":"07","pmid":1,"article_number":"20190528","article_type":"original","publication":"Philosophical Transactions of the Royal Society. Series B: Biological sciences","date_updated":"2023-08-22T08:21:31Z","year":"2020","oa":1,"isi":1,"type":"journal_article","quality_controlled":"1","language":[{"iso":"eng"}],"publisher":"The Royal Society","intvolume":"       375","main_file_link":[{"url":"https://doi.org/10.1098/rstb.2019.0528","open_access":"1"}],"date_published":"2020-07-12T00:00:00Z","external_id":{"isi":["000552662100001"],"pmid":["32654637"]},"date_created":"2020-07-26T22:01:01Z","scopus_import":"1","department":[{"_id":"NiBa"}],"user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8"},{"language":[{"iso":"eng"}],"type":"journal_article","quality_controlled":"1","isi":1,"publisher":"The Royal Society","intvolume":"       375","date_created":"2020-07-26T22:01:02Z","scopus_import":"1","date_published":"2020-07-12T00:00:00Z","external_id":{"isi":["000552662100013"],"pmid":["32654641"]},"user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","department":[{"_id":"NiBa"}],"article_number":"20190544","article_type":"original","date_updated":"2023-08-22T08:23:24Z","publication":"Philosophical Transactions of the Royal Society. Series B: Biological Sciences","year":"2020","volume":375,"article_processing_charge":"No","oa_version":"Published Version","pmid":1,"month":"07","citation":{"chicago":"Shang, Huiying, Jaqueline Hess, Melinda Pickup, David Field, Pär K. Ingvarsson, Jianquan Liu, and Christian Lexer. “Evolution of Strong Reproductive Isolation in Plants: Broad-Scale Patterns and Lessons from a Perennial Model Group.” <i>Philosophical Transactions of the Royal Society. Series B: Biological Sciences</i>. The Royal Society, 2020. <a href=\"https://doi.org/10.1098/rstb.2019.0544\">https://doi.org/10.1098/rstb.2019.0544</a>.","mla":"Shang, Huiying, et al. “Evolution of Strong Reproductive Isolation in Plants: Broad-Scale Patterns and Lessons from a Perennial Model Group.” <i>Philosophical Transactions of the Royal Society. Series B: Biological Sciences</i>, vol. 375, no. 1806, 20190544, The Royal Society, 2020, doi:<a href=\"https://doi.org/10.1098/rstb.2019.0544\">10.1098/rstb.2019.0544</a>.","ista":"Shang H, Hess J, Pickup M, Field D, Ingvarsson PK, Liu J, Lexer C. 2020. Evolution of strong reproductive isolation in plants: Broad-scale patterns and lessons from a perennial model group. Philosophical Transactions of the Royal Society. Series B: Biological Sciences. 375(1806), 20190544.","ama":"Shang H, Hess J, Pickup M, et al. Evolution of strong reproductive isolation in plants: Broad-scale patterns and lessons from a perennial model group. <i>Philosophical Transactions of the Royal Society Series B: Biological Sciences</i>. 2020;375(1806). doi:<a href=\"https://doi.org/10.1098/rstb.2019.0544\">10.1098/rstb.2019.0544</a>","short":"H. Shang, J. Hess, M. Pickup, D. Field, P.K. Ingvarsson, J. Liu, C. Lexer, Philosophical Transactions of the Royal Society. Series B: Biological Sciences 375 (2020).","apa":"Shang, H., Hess, J., Pickup, M., Field, D., Ingvarsson, P. K., Liu, J., &#38; Lexer, C. (2020). Evolution of strong reproductive isolation in plants: Broad-scale patterns and lessons from a perennial model group. <i>Philosophical Transactions of the Royal Society. Series B: Biological Sciences</i>. The Royal Society. <a href=\"https://doi.org/10.1098/rstb.2019.0544\">https://doi.org/10.1098/rstb.2019.0544</a>","ieee":"H. Shang <i>et al.</i>, “Evolution of strong reproductive isolation in plants: Broad-scale patterns and lessons from a perennial model group,” <i>Philosophical Transactions of the Royal Society. Series B: Biological Sciences</i>, vol. 375, no. 1806. The Royal Society, 2020."},"day":"12","status":"public","acknowledgement":"This work was supported by a fellowship from the China Scholarship Council (CSC) to H.S., Swiss National Science Foundation (SNF) grant no. 31003A_149306 to C.L., doctoral programme grant W1225-B20 to a faculty team including C.L., and the University of Vienna. We thank members of J.L.’s lab for collecting samples, Michael Barfuss and Elfi Grasserbauer for help in the laboratory, the Next Generation Sequencing Platform of the University of Berne for sequencing, the Vienna Scientific Cluster (VSC) for access to computational resources, and Claus Vogel and members of the PopGen Vienna graduate school for helpful discussions.","publication_status":"published","publication_identifier":{"eissn":["14712970"]},"doi":"10.1098/rstb.2019.0544","abstract":[{"text":"Many recent studies have addressed the mechanisms operating during the early stages of speciation, but surprisingly few studies have tested theoretical predictions on the evolution of strong reproductive isolation (RI). To help address this gap, we first undertook a quantitative review of the hybrid zone literature for flowering plants in relation to reproductive barriers. Then, using Populus as an exemplary model group, we analysed genome-wide variation for phylogenetic tree topologies in both early- and late-stage speciation taxa to determine how these patterns may be related to the genomic architecture of RI. Our plant literature survey revealed variation in barrier complexity and an association between barrier number and introgressive gene flow. Focusing on Populus, our genome-wide analysis of tree topologies in speciating poplar taxa points to unusually complex genomic architectures of RI, consistent with earlier genome-wide association studies. These architectures appear to facilitate the ‘escape’ of introgressed genome segments from polygenic barriers even with strong RI, thus affecting their relationships with recombination rates. Placed within the context of the broader literature, our data illustrate how phylogenomic approaches hold great promise for addressing the evolution and temporary breakdown of RI during late stages of speciation.","lang":"eng"}],"issue":"1806","_id":"8169","title":"Evolution of strong reproductive isolation in plants: Broad-scale patterns and lessons from a perennial model group","author":[{"full_name":"Shang, Huiying","last_name":"Shang","first_name":"Huiying"},{"last_name":"Hess","full_name":"Hess, Jaqueline","first_name":"Jaqueline"},{"orcid":"0000-0001-6118-0541","first_name":"Melinda","id":"2C78037E-F248-11E8-B48F-1D18A9856A87","last_name":"Pickup","full_name":"Pickup, Melinda"},{"last_name":"Field","full_name":"Field, David","first_name":"David","id":"419049E2-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-4014-8478"},{"first_name":"Pär K.","full_name":"Ingvarsson, Pär K.","last_name":"Ingvarsson"},{"first_name":"Jianquan","full_name":"Liu, Jianquan","last_name":"Liu"},{"last_name":"Lexer","full_name":"Lexer, Christian","first_name":"Christian"}]},{"year":"2020","oa":1,"article_type":"original","article_number":"013001","publication":"Physical Review Letters","date_updated":"2024-08-07T07:16:52Z","external_id":{"arxiv":["2006.02694"],"isi":["000544526900006"]},"date_published":"2020-07-03T00:00:00Z","scopus_import":"1","date_created":"2020-07-26T22:01:02Z","department":[{"_id":"MiLe"}],"user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","isi":1,"language":[{"iso":"eng"}],"quality_controlled":"1","type":"journal_article","intvolume":"       125","main_file_link":[{"url":"https://arxiv.org/abs/2006.02694","open_access":"1"}],"publisher":"American Physical Society","issue":"1","abstract":[{"text":"Alignment of OCS, CS2, and I2 molecules embedded in helium nanodroplets is measured as a function\r\nof time following rotational excitation by a nonresonant, comparatively weak ps laser pulse. The distinct\r\npeaks in the power spectra, obtained by Fourier analysis, are used to determine the rotational, B, and\r\ncentrifugal distortion, D, constants. For OCS, B and D match the values known from IR spectroscopy. For\r\nCS2 and I2, they are the first experimental results reported. The alignment dynamics calculated from the\r\ngas-phase rotational Schrödinger equation, using the experimental in-droplet B and D values, agree in\r\ndetail with the measurement for all three molecules. The rotational spectroscopy technique for molecules in\r\nhelium droplets introduced here should apply to a range of molecules and complexes.","lang":"eng"}],"doi":"10.1103/PhysRevLett.125.013001","author":[{"full_name":"Chatterley, Adam S.","last_name":"Chatterley","first_name":"Adam S."},{"full_name":"Christiansen, Lars","last_name":"Christiansen","first_name":"Lars"},{"first_name":"Constant A.","full_name":"Schouder, Constant A.","last_name":"Schouder"},{"last_name":"Jørgensen","full_name":"Jørgensen, Anders V.","first_name":"Anders V."},{"first_name":"Benjamin","last_name":"Shepperson","full_name":"Shepperson, Benjamin"},{"first_name":"Igor","id":"339C7E5A-F248-11E8-B48F-1D18A9856A87","last_name":"Cherepanov","full_name":"Cherepanov, Igor"},{"id":"4CA96FD4-F248-11E8-B48F-1D18A9856A87","first_name":"Giacomo","full_name":"Bighin, Giacomo","last_name":"Bighin","orcid":"0000-0001-8823-9777"},{"full_name":"Zillich, Robert E.","last_name":"Zillich","first_name":"Robert E."},{"full_name":"Lemeshko, Mikhail","last_name":"Lemeshko","id":"37CB05FA-F248-11E8-B48F-1D18A9856A87","first_name":"Mikhail","orcid":"0000-0002-6990-7802"},{"first_name":"Henrik","full_name":"Stapelfeldt, Henrik","last_name":"Stapelfeldt"}],"title":"Rotational coherence spectroscopy of molecules in Helium nanodroplets: Reconciling the time and the frequency domains","_id":"8170","status":"public","acknowledgement":"H. S. acknowledges support from the European Research Council-AdG (Project No. 320459, DropletControl)\r\nand from The Villum Foundation through a Villum Investigator Grant No. 25886. M. L. acknowledges support\r\nby the Austrian Science Fund (FWF), under Project No. P29902-N27, and by the European Research Council\r\n(ERC) Starting Grant No. 801770 (ANGULON). G. B. acknowledges support from the Austrian Science Fund\r\n(FWF), under Project No. M2641-N27. I. C. acknowledges support by the European Union’s Horizon 2020 research and\r\ninnovation programme under the Marie Skłodowska-Curie Grant Agreement No. 665385. Computational resources for\r\nthe PIMC simulations were provided by the division for scientific computing at the Johannes Kepler University.","publication_status":"published","ec_funded":1,"publication_identifier":{"eissn":["10797114"],"issn":["00319007"]},"project":[{"_id":"26031614-B435-11E9-9278-68D0E5697425","grant_number":"P29902","name":"Quantum rotations in the presence of a many-body environment","call_identifier":"FWF"},{"_id":"2688CF98-B435-11E9-9278-68D0E5697425","grant_number":"801770","name":"Angulon: physics and applications of a new quasiparticle","call_identifier":"H2020"},{"_id":"26986C82-B435-11E9-9278-68D0E5697425","grant_number":"M02641","call_identifier":"FWF","name":"A path-integral approach to composite impurities"},{"grant_number":"665385","_id":"2564DBCA-B435-11E9-9278-68D0E5697425","call_identifier":"H2020","name":"International IST Doctoral Program"}],"oa_version":"Preprint","day":"03","citation":{"mla":"Chatterley, Adam S., et al. “Rotational Coherence Spectroscopy of Molecules in Helium Nanodroplets: Reconciling the Time and the Frequency Domains.” <i>Physical Review Letters</i>, vol. 125, no. 1, 013001, American Physical Society, 2020, doi:<a href=\"https://doi.org/10.1103/PhysRevLett.125.013001\">10.1103/PhysRevLett.125.013001</a>.","chicago":"Chatterley, Adam S., Lars Christiansen, Constant A. Schouder, Anders V. Jørgensen, Benjamin Shepperson, Igor Cherepanov, Giacomo Bighin, Robert E. Zillich, Mikhail Lemeshko, and Henrik Stapelfeldt. “Rotational Coherence Spectroscopy of Molecules in Helium Nanodroplets: Reconciling the Time and the Frequency Domains.” <i>Physical Review Letters</i>. American Physical Society, 2020. <a href=\"https://doi.org/10.1103/PhysRevLett.125.013001\">https://doi.org/10.1103/PhysRevLett.125.013001</a>.","ista":"Chatterley AS, Christiansen L, Schouder CA, Jørgensen AV, Shepperson B, Cherepanov I, Bighin G, Zillich RE, Lemeshko M, Stapelfeldt H. 2020. Rotational coherence spectroscopy of molecules in Helium nanodroplets: Reconciling the time and the frequency domains. Physical Review Letters. 125(1), 013001.","ama":"Chatterley AS, Christiansen L, Schouder CA, et al. Rotational coherence spectroscopy of molecules in Helium nanodroplets: Reconciling the time and the frequency domains. <i>Physical Review Letters</i>. 2020;125(1). doi:<a href=\"https://doi.org/10.1103/PhysRevLett.125.013001\">10.1103/PhysRevLett.125.013001</a>","short":"A.S. Chatterley, L. Christiansen, C.A. Schouder, A.V. Jørgensen, B. Shepperson, I. Cherepanov, G. Bighin, R.E. Zillich, M. Lemeshko, H. Stapelfeldt, Physical Review Letters 125 (2020).","apa":"Chatterley, A. S., Christiansen, L., Schouder, C. A., Jørgensen, A. V., Shepperson, B., Cherepanov, I., … Stapelfeldt, H. (2020). Rotational coherence spectroscopy of molecules in Helium nanodroplets: Reconciling the time and the frequency domains. <i>Physical Review Letters</i>. American Physical Society. <a href=\"https://doi.org/10.1103/PhysRevLett.125.013001\">https://doi.org/10.1103/PhysRevLett.125.013001</a>","ieee":"A. S. Chatterley <i>et al.</i>, “Rotational coherence spectroscopy of molecules in Helium nanodroplets: Reconciling the time and the frequency domains,” <i>Physical Review Letters</i>, vol. 125, no. 1. American Physical Society, 2020."},"month":"07","article_processing_charge":"No","volume":125,"arxiv":1}]