[{"intvolume":"     13505","main_file_link":[{"open_access":"1","url":"https://doi.org/10.48550/arXiv.2208.06383"}],"publisher":"Springer Nature","type":"conference","language":[{"iso":"eng"}],"quality_controlled":"1","department":[{"_id":"ToHe"}],"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","date_published":"2022-10-21T00:00:00Z","external_id":{"arxiv":["2208.06383"]},"scopus_import":"1","date_created":"2023-01-12T12:11:16Z","publication":"20th International Symposium on Automated Technology for Verification and Analysis","date_updated":"2023-02-13T09:27:55Z","page":"337-353","oa":1,"year":"2022","alternative_title":["LNCS"],"arxiv":1,"volume":13505,"article_processing_charge":"No","day":"21","citation":{"chicago":"Garcia Soto, Miriam, Thomas A Henzinger, and Christian Schilling. “Synthesis of Parametric Hybrid Automata from Time Series.” In <i>20th International Symposium on Automated Technology for Verification and Analysis</i>, 13505:337–53. Springer Nature, 2022. <a href=\"https://doi.org/10.1007/978-3-031-19992-9_22\">https://doi.org/10.1007/978-3-031-19992-9_22</a>.","mla":"Garcia Soto, Miriam, et al. “Synthesis of Parametric Hybrid Automata from Time Series.” <i>20th International Symposium on Automated Technology for Verification and Analysis</i>, vol. 13505, Springer Nature, 2022, pp. 337–53, doi:<a href=\"https://doi.org/10.1007/978-3-031-19992-9_22\">10.1007/978-3-031-19992-9_22</a>.","short":"M. Garcia Soto, T.A. Henzinger, C. Schilling, in:, 20th International Symposium on Automated Technology for Verification and Analysis, Springer Nature, 2022, pp. 337–353.","ama":"Garcia Soto M, Henzinger TA, Schilling C. Synthesis of parametric hybrid automata from time series. In: <i>20th International Symposium on Automated Technology for Verification and Analysis</i>. Vol 13505. Springer Nature; 2022:337-353. doi:<a href=\"https://doi.org/10.1007/978-3-031-19992-9_22\">10.1007/978-3-031-19992-9_22</a>","ista":"Garcia Soto M, Henzinger TA, Schilling C. 2022. Synthesis of parametric hybrid automata from time series. 20th International Symposium on Automated Technology for Verification and Analysis. ATVA: Automated Technology for Verification and Analysis, LNCS, vol. 13505, 337–353.","ieee":"M. Garcia Soto, T. A. Henzinger, and C. Schilling, “Synthesis of parametric hybrid automata from time series,” in <i>20th International Symposium on Automated Technology for Verification and Analysis</i>, Virtual, 2022, vol. 13505, pp. 337–353.","apa":"Garcia Soto, M., Henzinger, T. A., &#38; Schilling, C. (2022). Synthesis of parametric hybrid automata from time series. In <i>20th International Symposium on Automated Technology for Verification and Analysis</i> (Vol. 13505, pp. 337–353). Virtual: Springer Nature. <a href=\"https://doi.org/10.1007/978-3-031-19992-9_22\">https://doi.org/10.1007/978-3-031-19992-9_22</a>"},"month":"10","conference":{"name":"ATVA: Automated Technology for Verification and Analysis","end_date":"2022-10-28","location":"Virtual","start_date":"2022-10-25"},"oa_version":"Preprint","publication_identifier":{"eissn":["1611-3349"],"issn":["0302-9743"],"eisbn":["9783031199929"],"isbn":["9783031199912"]},"project":[{"grant_number":"101020093","_id":"62781420-2b32-11ec-9570-8d9b63373d4d","name":"Vigilant Algorithmic Monitoring of Software","call_identifier":"H2020"}],"publication_status":"published","acknowledgement":"This work was supported in part by the European Union’s Horizon 2020 research and innovation programme under the Marie Skłodowska-Curie grant agreement no. 847635, by the ERC-2020-AdG 101020093, by DIREC - Digital Research Centre Denmark, and by the Villum Investigator Grant S4OS.","status":"public","ec_funded":1,"author":[{"id":"4B3207F6-F248-11E8-B48F-1D18A9856A87","first_name":"Miriam","full_name":"Garcia Soto, Miriam","last_name":"Garcia Soto","orcid":"0000-0003-2936-5719"},{"orcid":"0000-0002-2985-7724","first_name":"Thomas A","id":"40876CD8-F248-11E8-B48F-1D18A9856A87","last_name":"Henzinger","full_name":"Henzinger, Thomas A"},{"orcid":"0000-0003-3658-1065","full_name":"Schilling, Christian","last_name":"Schilling","id":"3A2F4DCE-F248-11E8-B48F-1D18A9856A87","first_name":"Christian"}],"title":"Synthesis of parametric hybrid automata from time series","_id":"12171","abstract":[{"text":"We propose an algorithmic approach for synthesizing linear hybrid automata from time-series data. Unlike existing approaches, our approach provides a whole family of models with the same discrete structure but different dynamics. Each model in the family is guaranteed to capture the input data up to a precision error ε, in the following sense: For each time series, the model contains an execution that is ε-close to the data points. Our construction allows to effectively choose a model from this family with minimal precision error ε. We demonstrate the algorithm’s efficiency and its ability to find precise models in two case studies.","lang":"eng"}],"doi":"10.1007/978-3-031-19992-9_22"},{"publication":"Gut Microbes","date_updated":"2023-08-04T09:10:18Z","article_number":"e2143218","article_type":"original","oa":1,"year":"2022","keyword":["Infectious Diseases","Microbiology (medical)","Gastroenterology","Microbiology"],"publisher":"Taylor & Francis","intvolume":"        14","isi":1,"type":"journal_article","quality_controlled":"1","language":[{"iso":"eng"}],"department":[{"_id":"FyKo"}],"user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","external_id":{"isi":["000889180100001"]},"date_published":"2022-11-22T00:00:00Z","date_created":"2023-01-12T12:11:36Z","scopus_import":"1","publication_identifier":{"issn":["1949-0976"],"eissn":["1949-0984"]},"publication_status":"published","acknowledgement":"We would like to acknowledge Anita Krnjic, Christina Gmainer, Marion Nehr, Helga Mock, and Sena Ecin for technical support in conducting the experiments.\r\nThis study was supported by the Austrian Science Fund (P 32302) and the Vienna Science and Technology Fund (LS18- 053; Austrian Science Fund (FWF)) [P 32302].","status":"public","title":"Atypical enteropathogenic E. coli are associated with disease activity in ulcerative colitis","author":[{"last_name":"Baumgartner","full_name":"Baumgartner, Maximilian","first_name":"Maximilian"},{"last_name":"Zirnbauer","full_name":"Zirnbauer, Rebecca","first_name":"Rebecca"},{"full_name":"Schlager, Sabine","last_name":"Schlager","first_name":"Sabine"},{"first_name":"Daniel","full_name":"Mertens, Daniel","last_name":"Mertens"},{"first_name":"Nikolaus","full_name":"Gasche, Nikolaus","last_name":"Gasche"},{"last_name":"Sladek","full_name":"Sladek, Barbara","first_name":"Barbara"},{"first_name":"Craig","full_name":"Herbold, Craig","last_name":"Herbold"},{"first_name":"Olga","full_name":"Bochkareva, Olga","last_name":"Bochkareva"},{"id":"20152b9d-927a-11ed-8107-be36d740812d","first_name":"Vera","full_name":"Emelianenko, Vera","last_name":"Emelianenko"},{"full_name":"Vogelsang, Harald","last_name":"Vogelsang","first_name":"Harald"},{"last_name":"Lang","full_name":"Lang, Michaela","first_name":"Michaela"},{"first_name":"Anton","last_name":"Klotz","full_name":"Klotz, Anton"},{"full_name":"Moik, Birgit","last_name":"Moik","first_name":"Birgit"},{"first_name":"Athanasios","last_name":"Makristathis","full_name":"Makristathis, Athanasios"},{"first_name":"David","last_name":"Berry","full_name":"Berry, David"},{"first_name":"Stefanie","last_name":"Dabsch","full_name":"Dabsch, Stefanie"},{"first_name":"Vineeta","full_name":"Khare, Vineeta","last_name":"Khare"},{"last_name":"Gasche","full_name":"Gasche, Christoph","first_name":"Christoph"}],"_id":"12173","abstract":[{"text":"With increasing urbanization and industrialization, the prevalence of inflammatory bowel diseases (IBDs) has steadily been rising over the past two decades. IBD involves flares of gastrointestinal (GI) inflammation accompanied by microbiota perturbations. However, microbial mechanisms that trigger such flares remain elusive. Here, we analyzed the association of the emerging pathogen atypical enteropathogenic E. coli (aEPEC) with IBD disease activity. The presence of diarrheagenic E. coli was assessed in stool samples from 630 IBD patients and 234 age- and sex-matched controls without GI symptoms. Microbiota was analyzed with 16S ribosomal RNA gene amplicon sequencing, and 57 clinical aEPEC isolates were subjected to whole-genome sequencing and in vitro pathogenicity experiments including biofilm formation, epithelial barrier function and the ability to induce pro-inflammatory signaling. The presence of aEPEC correlated with laboratory, clinical and endoscopic disease activity in ulcerative colitis (UC), as well as microbiota dysbiosis. In vitro, aEPEC strains induce epithelial p21-activated kinases, disrupt the epithelial barrier and display potent biofilm formation. The effector proteins espV and espG2 distinguish aEPEC cultured from UC and Crohn’s disease patients, respectively. EspV-positive aEPEC harbor more virulence factors and have a higher pro-inflammatory potential, which is counteracted by 5-ASA. aEPEC may tip a fragile immune–microbiota homeostasis and thereby contribute to flares in UC. aEPEC isolates from UC patients display properties to disrupt the epithelial barrier and to induce pro-inflammatory signaling in vitro.","lang":"eng"}],"issue":"1","doi":"10.1080/19490976.2022.2143218","file":[{"file_size":4075251,"relation":"main_file","creator":"dernst","file_name":"2022_GutMicrobes_Baumgartner.pdf","date_updated":"2023-01-26T10:56:51Z","success":1,"content_type":"application/pdf","checksum":"ee7681a17ae27645e9b5c1df61c15429","access_level":"open_access","date_created":"2023-01-26T10:56:51Z","file_id":"12400"}],"tmp":{"name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","image":"/images/cc_by.png","short":"CC BY (4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode"},"has_accepted_license":"1","article_processing_charge":"No","volume":14,"citation":{"short":"M. Baumgartner, R. Zirnbauer, S. Schlager, D. Mertens, N. Gasche, B. Sladek, C. Herbold, O. Bochkareva, V. Emelianenko, H. Vogelsang, M. Lang, A. Klotz, B. Moik, A. Makristathis, D. Berry, S. Dabsch, V. Khare, C. Gasche, Gut Microbes 14 (2022).","ista":"Baumgartner M, Zirnbauer R, Schlager S, Mertens D, Gasche N, Sladek B, Herbold C, Bochkareva O, Emelianenko V, Vogelsang H, Lang M, Klotz A, Moik B, Makristathis A, Berry D, Dabsch S, Khare V, Gasche C. 2022. Atypical enteropathogenic E. coli are associated with disease activity in ulcerative colitis. Gut Microbes. 14(1), e2143218.","ama":"Baumgartner M, Zirnbauer R, Schlager S, et al. Atypical enteropathogenic E. coli are associated with disease activity in ulcerative colitis. <i>Gut Microbes</i>. 2022;14(1). doi:<a href=\"https://doi.org/10.1080/19490976.2022.2143218\">10.1080/19490976.2022.2143218</a>","ieee":"M. Baumgartner <i>et al.</i>, “Atypical enteropathogenic E. coli are associated with disease activity in ulcerative colitis,” <i>Gut Microbes</i>, vol. 14, no. 1. Taylor &#38; Francis, 2022.","apa":"Baumgartner, M., Zirnbauer, R., Schlager, S., Mertens, D., Gasche, N., Sladek, B., … Gasche, C. (2022). Atypical enteropathogenic E. coli are associated with disease activity in ulcerative colitis. <i>Gut Microbes</i>. Taylor &#38; Francis. <a href=\"https://doi.org/10.1080/19490976.2022.2143218\">https://doi.org/10.1080/19490976.2022.2143218</a>","chicago":"Baumgartner, Maximilian, Rebecca Zirnbauer, Sabine Schlager, Daniel Mertens, Nikolaus Gasche, Barbara Sladek, Craig Herbold, et al. “Atypical Enteropathogenic E. Coli Are Associated with Disease Activity in Ulcerative Colitis.” <i>Gut Microbes</i>. Taylor &#38; Francis, 2022. <a href=\"https://doi.org/10.1080/19490976.2022.2143218\">https://doi.org/10.1080/19490976.2022.2143218</a>.","mla":"Baumgartner, Maximilian, et al. “Atypical Enteropathogenic E. Coli Are Associated with Disease Activity in Ulcerative Colitis.” <i>Gut Microbes</i>, vol. 14, no. 1, e2143218, Taylor &#38; Francis, 2022, doi:<a href=\"https://doi.org/10.1080/19490976.2022.2143218\">10.1080/19490976.2022.2143218</a>."},"day":"22","file_date_updated":"2023-01-26T10:56:51Z","ddc":["570"],"month":"11","oa_version":"Published Version"},{"keyword":["Neurology (clinical)"],"year":"2022","oa":1,"article_type":"original","page":"2687-2703","date_updated":"2023-08-04T09:13:08Z","publication":"Brain","acknowledged_ssus":[{"_id":"EM-Fac"},{"_id":"LifeSc"}],"scopus_import":"1","date_created":"2023-01-12T12:11:45Z","date_published":"2022-08-01T00:00:00Z","external_id":{"isi":["000807770000001"]},"user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","department":[{"_id":"GaNo"}],"quality_controlled":"1","language":[{"iso":"eng"}],"type":"journal_article","isi":1,"intvolume":"       145","main_file_link":[{"url":"https://doi.org/10.1093/brain/awac145","open_access":"1"}],"publisher":"Oxford University Press","doi":"10.1093/brain/awac145","issue":"8","abstract":[{"lang":"eng","text":"Vacuolar-type H+-ATPase (V-ATPase) is a multimeric complex present in a variety of cellular membranes that acts as an ATP-dependent proton pump and plays a key role in pH homeostasis and intracellular signalling pathways. In humans, 22 autosomal genes encode for a redundant set of subunits allowing the composition of diverse V-ATPase complexes with specific properties and expression. Sixteen subunits have been linked to human disease.\r\nHere we describe 26 patients harbouring 20 distinct pathogenic de novo missense ATP6V1A variants, mainly clustering within the ATP synthase α/β family-nucleotide-binding domain. At a mean age of 7 years (extremes: 6 weeks, youngest deceased patient to 22 years, oldest patient) clinical pictures included early lethal encephalopathies with rapidly progressive massive brain atrophy, severe developmental epileptic encephalopathies and static intellectual disability with epilepsy. The first clinical manifestation was early hypotonia, in 70%; 81% developed epilepsy, manifested as developmental epileptic encephalopathies in 58% of the cohort and with infantile spasms in 62%; 63% of developmental epileptic encephalopathies failed to achieve any developmental, communicative or motor skills. Less severe outcomes were observed in 23% of patients who, at a mean age of 10 years and 6 months, exhibited moderate intellectual disability, with independent walking and variable epilepsy. None of the patients developed communicative language. Microcephaly (38%) and amelogenesis imperfecta/enamel dysplasia (42%) were additional clinical features. Brain MRI demonstrated hypomyelination and generalized atrophy in 68%. Atrophy was progressive in all eight individuals undergoing repeated MRIs.</jats:p>\r\n               <jats:p>Fibroblasts of two patients with developmental epileptic encephalopathies showed decreased LAMP1 expression, Lysotracker staining and increased organelle pH, consistent with lysosomal impairment and loss of V-ATPase function. Fibroblasts of two patients with milder disease, exhibited a different phenotype with increased Lysotracker staining, decreased organelle pH and no significant modification in LAMP1 expression. Quantification of substrates for lysosomal enzymes in cellular extracts from four patients revealed discrete accumulation. Transmission electron microscopy of fibroblasts of four patients with variable severity and of induced pluripotent stem cell-derived neurons from two patients with developmental epileptic encephalopathies showed electron-dense inclusions, lipid droplets, osmiophilic material and lamellated membrane structures resembling phospholipids. Quantitative assessment in induced pluripotent stem cell-derived neurons identified significantly smaller lysosomes.\r\nATP6V1A-related encephalopathy represents a new paradigm among lysosomal disorders. It results from a dysfunctional endo-lysosomal membrane protein causing altered pH homeostasis. Its pathophysiology implies intracellular accumulation of substrates whose composition remains unclear, and a combination of developmental brain abnormalities and neurodegenerative changes established during prenatal and early postanal development, whose severity is variably determined by specific pathogenic variants."}],"_id":"12174","author":[{"first_name":"Renzo","last_name":"Guerrini","full_name":"Guerrini, Renzo"},{"full_name":"Mei, Davide","last_name":"Mei","first_name":"Davide"},{"full_name":"Szigeti, Margit Katalin","last_name":"Szigeti","id":"44F4BDC0-F248-11E8-B48F-1D18A9856A87","first_name":"Margit Katalin","orcid":"0000-0001-9500-8758"},{"first_name":"Sara","last_name":"Pepe","full_name":"Pepe, Sara"},{"first_name":"Mary Kay","full_name":"Koenig, Mary Kay","last_name":"Koenig"},{"last_name":"Von Allmen","full_name":"Von Allmen, Gretchen","first_name":"Gretchen"},{"first_name":"Megan T","full_name":"Cho, Megan T","last_name":"Cho"},{"first_name":"Kimberly","last_name":"McDonald","full_name":"McDonald, Kimberly"},{"first_name":"Janice","last_name":"Baker","full_name":"Baker, Janice"},{"first_name":"Vikas","last_name":"Bhambhani","full_name":"Bhambhani, Vikas"},{"first_name":"Zöe","full_name":"Powis, Zöe","last_name":"Powis"},{"full_name":"Rodan, Lance","last_name":"Rodan","first_name":"Lance"},{"last_name":"Nabbout","full_name":"Nabbout, Rima","first_name":"Rima"},{"full_name":"Barcia, Giulia","last_name":"Barcia","first_name":"Giulia"},{"first_name":"Jill A","full_name":"Rosenfeld, Jill A","last_name":"Rosenfeld"},{"first_name":"Carlos A","last_name":"Bacino","full_name":"Bacino, Carlos A"},{"full_name":"Mignot, Cyril","last_name":"Mignot","first_name":"Cyril"},{"first_name":"Lillian H","last_name":"Power","full_name":"Power, Lillian H"},{"first_name":"Catharine J","full_name":"Harris, Catharine J","last_name":"Harris"},{"last_name":"Marjanovic","full_name":"Marjanovic, Dragan","first_name":"Dragan"},{"last_name":"Møller","full_name":"Møller, Rikke S","first_name":"Rikke S"},{"full_name":"Hammer, Trine B","last_name":"Hammer","first_name":"Trine B"},{"first_name":"Riikka","last_name":"Keski Filppula","full_name":"Keski Filppula, Riikka"},{"last_name":"Vieira","full_name":"Vieira, Päivi","first_name":"Päivi"},{"last_name":"Hildebrandt","full_name":"Hildebrandt, Clara","first_name":"Clara"},{"first_name":"Stephanie","last_name":"Sacharow","full_name":"Sacharow, Stephanie"},{"full_name":"Maragliano, Luca","last_name":"Maragliano","first_name":"Luca"},{"full_name":"Benfenati, Fabio","last_name":"Benfenati","first_name":"Fabio"},{"full_name":"Lachlan, Katherine","last_name":"Lachlan","first_name":"Katherine"},{"first_name":"Andreas","last_name":"Benneche","full_name":"Benneche, Andreas"},{"first_name":"Florence","last_name":"Petit","full_name":"Petit, Florence"},{"first_name":"Jean Madeleine","full_name":"de Sainte Agathe, Jean Madeleine","last_name":"de Sainte Agathe"},{"first_name":"Barbara","last_name":"Hallinan","full_name":"Hallinan, Barbara"},{"first_name":"Yue","last_name":"Si","full_name":"Si, Yue"},{"first_name":"Ingrid M","last_name":"Wentzensen","full_name":"Wentzensen, Ingrid M"},{"full_name":"Zou, Fanggeng","last_name":"Zou","first_name":"Fanggeng"},{"last_name":"Narayanan","full_name":"Narayanan, Vinodh","first_name":"Vinodh"},{"first_name":"Naomichi","full_name":"Matsumoto, Naomichi","last_name":"Matsumoto"},{"full_name":"Boncristiano, Alessandra","last_name":"Boncristiano","first_name":"Alessandra"},{"first_name":"Giancarlo","full_name":"la Marca, Giancarlo","last_name":"la Marca"},{"last_name":"Kato","full_name":"Kato, Mitsuhiro","first_name":"Mitsuhiro"},{"first_name":"Kristin","last_name":"Anderson","full_name":"Anderson, Kristin"},{"full_name":"Barba, Carmen","last_name":"Barba","first_name":"Carmen"},{"first_name":"Luisa","full_name":"Sturiale, Luisa","last_name":"Sturiale"},{"first_name":"Domenico","full_name":"Garozzo, Domenico","last_name":"Garozzo"},{"last_name":"Bei","full_name":"Bei, Roberto","first_name":"Roberto"},{"first_name":"Laura","full_name":"Masuelli, Laura","last_name":"Masuelli"},{"first_name":"Valerio","full_name":"Conti, Valerio","last_name":"Conti"},{"id":"3E57A680-F248-11E8-B48F-1D18A9856A87","first_name":"Gaia","full_name":"Novarino, Gaia","last_name":"Novarino","orcid":"0000-0002-7673-7178"},{"full_name":"Fassio, Anna","last_name":"Fassio","first_name":"Anna"}],"title":"Phenotypic and genetic spectrum of ATP6V1A encephalopathy: A disorder of lysosomal homeostasis","ec_funded":1,"acknowledgement":"We thank all patients and family members for their participation in this study. We thank Melanie Pieraks and Eva Reinthaler (Neurolentech, Austria) for generating the human iPSC lines and\r\nfor performing quality checks. We thank Vanessa Zheden and Daniel Gütl for their excellent technical support in the specimen preparation for transmission electron microscopy and Flavia Leite for preparing the lentiviruses. The support from Electron Microscopy Facility and Molecular Biology Services at IST Austria is greatly acknowledged. We would like to thank Doctors Jane Hurst and Richard Scott for their help in retrieving the detailed clinical information of Patient 17. The research team acknowledges the support of the National Institute for Health Research, through the Comprehensive Clinical Research Network. See Supplementary Material for Undiagnosed Disease Network consortium details. Genetic information on Patient 23 was made available through access to the data and findings generated by the 100 000 Genomes\r\nProject; www.genomicsengland.co.uk (to K.L.). \r\nThis work was supported by the EU 7th Framework Programme (FP7) under the project DESIRE grant N602531 (to R.G.); the Regione Toscana under the Call for Health 2018 (grant\r\nDECODE-EE) (to R.G.); the ‘Brain Project’ by Fondazione Cassa di Risparmio di Firenze (to R.G.); IRCCS Ospedale Policlinico San Martino 5×1000 and Ricerca Corrente (to A.F. and F.B.). The European Reference Network (ERN) for rare and complex epilepsies (EpiCARE) provided financial support for meetings organization. The DDD study presents independent research commissioned by the Health Innovation Challenge Fund (grant number HICF-1009-003), a parallel funding partnership between Wellcome and the Department of Health, and the Wellcome Sanger Institute (grant number WT098051). The views expressed in this publication\r\nare those of the author(s) and not necessarily those of Wellcome or the Department of Health. The study has UK Research Ethics Committee approval (10/H0305/83, granted by the Cambridge South REC, and GEN/284/12 granted by the Republic of Ireland REC). This study makes use of DECIPHER (https://www.deciphergenomics.org), which is funded by Wellcome. K.K.-S. was supported by the ISTplus fellowship. ","publication_status":"published","status":"public","project":[{"name":"ISTplus - Postdoctoral Fellowships","call_identifier":"H2020","grant_number":"754411","_id":"260C2330-B435-11E9-9278-68D0E5697425"}],"publication_identifier":{"eissn":["1460-2156"],"issn":["0006-8950"]},"oa_version":"Published Version","month":"08","day":"01","citation":{"ieee":"R. Guerrini <i>et al.</i>, “Phenotypic and genetic spectrum of ATP6V1A encephalopathy: A disorder of lysosomal homeostasis,” <i>Brain</i>, vol. 145, no. 8. Oxford University Press, pp. 2687–2703, 2022.","apa":"Guerrini, R., Mei, D., Szigeti, M. K., Pepe, S., Koenig, M. K., Von Allmen, G., … Fassio, A. (2022). Phenotypic and genetic spectrum of ATP6V1A encephalopathy: A disorder of lysosomal homeostasis. <i>Brain</i>. Oxford University Press. <a href=\"https://doi.org/10.1093/brain/awac145\">https://doi.org/10.1093/brain/awac145</a>","short":"R. Guerrini, D. Mei, M.K. Szigeti, S. Pepe, M.K. Koenig, G. Von Allmen, M.T. Cho, K. McDonald, J. Baker, V. Bhambhani, Z. Powis, L. Rodan, R. Nabbout, G. Barcia, J.A. Rosenfeld, C.A. Bacino, C. Mignot, L.H. Power, C.J. Harris, D. Marjanovic, R.S. Møller, T.B. Hammer, R. Keski Filppula, P. Vieira, C. Hildebrandt, S. Sacharow, L. Maragliano, F. Benfenati, K. Lachlan, A. Benneche, F. Petit, J.M. de Sainte Agathe, B. Hallinan, Y. Si, I.M. Wentzensen, F. Zou, V. Narayanan, N. Matsumoto, A. Boncristiano, G. la Marca, M. Kato, K. Anderson, C. Barba, L. Sturiale, D. Garozzo, R. Bei, L. Masuelli, V. Conti, G. Novarino, A. Fassio, Brain 145 (2022) 2687–2703.","ista":"Guerrini R, Mei D, Szigeti MK, Pepe S, Koenig MK, Von Allmen G, Cho MT, McDonald K, Baker J, Bhambhani V, Powis Z, Rodan L, Nabbout R, Barcia G, Rosenfeld JA, Bacino CA, Mignot C, Power LH, Harris CJ, Marjanovic D, Møller RS, Hammer TB, Keski Filppula R, Vieira P, Hildebrandt C, Sacharow S, Maragliano L, Benfenati F, Lachlan K, Benneche A, Petit F, de Sainte Agathe JM, Hallinan B, Si Y, Wentzensen IM, Zou F, Narayanan V, Matsumoto N, Boncristiano A, la Marca G, Kato M, Anderson K, Barba C, Sturiale L, Garozzo D, Bei R, Masuelli L, Conti V, Novarino G, Fassio A. 2022. Phenotypic and genetic spectrum of ATP6V1A encephalopathy: A disorder of lysosomal homeostasis. Brain. 145(8), 2687–2703.","ama":"Guerrini R, Mei D, Szigeti MK, et al. Phenotypic and genetic spectrum of ATP6V1A encephalopathy: A disorder of lysosomal homeostasis. <i>Brain</i>. 2022;145(8):2687-2703. doi:<a href=\"https://doi.org/10.1093/brain/awac145\">10.1093/brain/awac145</a>","chicago":"Guerrini, Renzo, Davide Mei, Margit Katalin Szigeti, Sara Pepe, Mary Kay Koenig, Gretchen Von Allmen, Megan T Cho, et al. “Phenotypic and Genetic Spectrum of ATP6V1A Encephalopathy: A Disorder of Lysosomal Homeostasis.” <i>Brain</i>. Oxford University Press, 2022. <a href=\"https://doi.org/10.1093/brain/awac145\">https://doi.org/10.1093/brain/awac145</a>.","mla":"Guerrini, Renzo, et al. “Phenotypic and Genetic Spectrum of ATP6V1A Encephalopathy: A Disorder of Lysosomal Homeostasis.” <i>Brain</i>, vol. 145, no. 8, Oxford University Press, 2022, pp. 2687–703, doi:<a href=\"https://doi.org/10.1093/brain/awac145\">10.1093/brain/awac145</a>."},"article_processing_charge":"No","volume":145},{"publication_identifier":{"eissn":["1611-3349"],"isbn":["9783031191343"],"issn":["0302-9743"],"eisbn":["9783031191350"]},"project":[{"_id":"62781420-2b32-11ec-9570-8d9b63373d4d","grant_number":"101020093","name":"Vigilant Algorithmic Monitoring of Software","call_identifier":"H2020"}],"status":"public","publication_status":"published","acknowledgement":"This work was supported in part by the ERC-2020-AdG 101020093, the EPSRC project EP/V025848/1, and the EPSRC project EP/X017796/1.","ec_funded":1,"author":[{"first_name":"Sougata","full_name":"Bose, Sougata","last_name":"Bose"},{"orcid":"0000-0002-2985-7724","first_name":"Thomas A","id":"40876CD8-F248-11E8-B48F-1D18A9856A87","last_name":"Henzinger","full_name":"Henzinger, Thomas A"},{"last_name":"Lehtinen","full_name":"Lehtinen, Karoliina","first_name":"Karoliina"},{"full_name":"Schewe, Sven","last_name":"Schewe","first_name":"Sven"},{"full_name":"Totzke, Patrick","last_name":"Totzke","first_name":"Patrick"}],"title":"History-deterministic timed automata are not determinizable","_id":"12175","abstract":[{"lang":"eng","text":"An automaton is history-deterministic (HD) if one can safely resolve its non-deterministic choices on the fly. In a recent paper, Henzinger, Lehtinen and Totzke studied this in the context of Timed Automata [9], where it was conjectured that the class of timed ω-languages recognised by HD-timed automata strictly extends that of deterministic ones. We provide a proof for this fact."}],"doi":"10.1007/978-3-031-19135-0_5","volume":13608,"article_processing_charge":"No","day":"12","citation":{"short":"S. Bose, T.A. Henzinger, K. Lehtinen, S. Schewe, P. Totzke, in:, 16th International Conference on Reachability Problems, Springer Nature, 2022, pp. 67–76.","ama":"Bose S, Henzinger TA, Lehtinen K, Schewe S, Totzke P. History-deterministic timed automata are not determinizable. In: <i>16th International Conference on Reachability Problems</i>. Vol 13608. Springer Nature; 2022:67-76. doi:<a href=\"https://doi.org/10.1007/978-3-031-19135-0_5\">10.1007/978-3-031-19135-0_5</a>","ista":"Bose S, Henzinger TA, Lehtinen K, Schewe S, Totzke P. 2022. History-deterministic timed automata are not determinizable. 16th International Conference on Reachability Problems. RC: Reachability Problems, LNCS, vol. 13608, 67–76.","apa":"Bose, S., Henzinger, T. A., Lehtinen, K., Schewe, S., &#38; Totzke, P. (2022). History-deterministic timed automata are not determinizable. In <i>16th International Conference on Reachability Problems</i> (Vol. 13608, pp. 67–76). Kaiserslautern, Germany: Springer Nature. <a href=\"https://doi.org/10.1007/978-3-031-19135-0_5\">https://doi.org/10.1007/978-3-031-19135-0_5</a>","ieee":"S. Bose, T. A. Henzinger, K. Lehtinen, S. Schewe, and P. Totzke, “History-deterministic timed automata are not determinizable,” in <i>16th International Conference on Reachability Problems</i>, Kaiserslautern, Germany, 2022, vol. 13608, pp. 67–76.","chicago":"Bose, Sougata, Thomas A Henzinger, Karoliina Lehtinen, Sven Schewe, and Patrick Totzke. “History-Deterministic Timed Automata Are Not Determinizable.” In <i>16th International Conference on Reachability Problems</i>, 13608:67–76. Springer Nature, 2022. <a href=\"https://doi.org/10.1007/978-3-031-19135-0_5\">https://doi.org/10.1007/978-3-031-19135-0_5</a>.","mla":"Bose, Sougata, et al. “History-Deterministic Timed Automata Are Not Determinizable.” <i>16th International Conference on Reachability Problems</i>, vol. 13608, Springer Nature, 2022, pp. 67–76, doi:<a href=\"https://doi.org/10.1007/978-3-031-19135-0_5\">10.1007/978-3-031-19135-0_5</a>."},"month":"10","conference":{"end_date":"2022-10-21","location":"Kaiserslautern, Germany","start_date":"2022-10-17","name":"RC: Reachability Problems"},"oa_version":"Preprint","publication":"16th International Conference on Reachability Problems","date_updated":"2023-09-05T15:12:08Z","page":"67-76","oa":1,"year":"2022","alternative_title":["LNCS"],"main_file_link":[{"url":"https://hal.science/hal-03849398/","open_access":"1"}],"intvolume":"     13608","publisher":"Springer Nature","quality_controlled":"1","language":[{"iso":"eng"}],"type":"conference","department":[{"_id":"ToHe"}],"user_id":"c635000d-4b10-11ee-a964-aac5a93f6ac1","date_published":"2022-10-12T00:00:00Z","scopus_import":"1","date_created":"2023-01-12T12:11:57Z"},{"acknowledgement":"We would like to thank the authors of [BHR+21] for clarifying several questions we had\r\nregarding their results. Pavel Hubá£ek was supported by the Grant Agency of the Czech\r\nRepublic under the grant agreement no. 19-27871X and by the Charles University project\r\nUNCE/SCI/004. Chethan Kamath is supported by Azrieli International Postdoctoral Fellowship\r\nand ISF grants 484/18 and 1789/19. Karen Klein was supported in part by ERC CoG grant\r\n724307 and conducted part of this work at Institute of Science and Technology Austria.","status":"public","publication_status":"published","publication_identifier":{"eissn":["1611-3349"],"isbn":["9783031159787"],"issn":["0302-9743"],"eisbn":["9783031159794"]},"doi":"10.1007/978-3-031-15979-4_13","abstract":[{"lang":"eng","text":"A proof of exponentiation (PoE) in a group G of unknown order allows a prover to convince a verifier that a tuple (x,q,T,y)∈G×N×N×G satisfies xqT=y. This primitive has recently found exciting applications in the constructions of verifiable delay functions and succinct arguments of knowledge. The most practical PoEs only achieve soundness either under computational assumptions, i.e., they are arguments (Wesolowski, Journal of Cryptology 2020), or in groups that come with the promise of not having any small subgroups (Pietrzak, ITCS 2019). The only statistically-sound PoE in general groups of unknown order is due to Block et al. (CRYPTO 2021), and can be seen as an elaborate parallel repetition of Pietrzak’s PoE: to achieve λ bits of security, say λ=80, the number of repetitions required (and thus the blow-up in communication) is as large as λ.\r\n\r\nIn this work, we propose a statistically-sound PoE for the case where the exponent q is the product of all primes up to some bound B. We show that, in this case, it suffices to run only λ/log(B) parallel instances of Pietrzak’s PoE, which reduces the concrete proof-size compared to Block et al. by an order of magnitude. Furthermore, we show that in the known applications where PoEs are used as a building block such structured exponents are viable. Finally, we also discuss batching of our PoE, showing that many proofs (for the same G and q but different x and T) can be batched by adding only a single element to the proof per additional statement."}],"_id":"12176","author":[{"id":"0f78d746-dc7d-11ea-9b2f-83f92091afe7","first_name":"Charlotte","full_name":"Hoffmann, Charlotte","last_name":"Hoffmann","orcid":"0000-0003-2027-5549"},{"last_name":"Hubáček","full_name":"Hubáček, Pavel","first_name":"Pavel"},{"first_name":"Chethan","full_name":"Kamath, Chethan","last_name":"Kamath"},{"first_name":"Karen","full_name":"Klein, Karen","last_name":"Klein"},{"orcid":"0000-0002-9139-1654","full_name":"Pietrzak, Krzysztof Z","last_name":"Pietrzak","id":"3E04A7AA-F248-11E8-B48F-1D18A9856A87","first_name":"Krzysztof Z"}],"title":"Practical statistically-sound proofs of exponentiation in any group","article_processing_charge":"No","volume":13508,"conference":{"name":"CRYYPTO: International Cryptology Conference","end_date":"2022-08-18","location":"Santa Barbara, CA, United States","start_date":"2022-08-15"},"oa_version":"Preprint","month":"10","day":"13","citation":{"chicago":"Hoffmann, Charlotte, Pavel Hubáček, Chethan Kamath, Karen Klein, and Krzysztof Z Pietrzak. “Practical Statistically-Sound Proofs of Exponentiation in Any Group.” In <i>Advances in Cryptology – CRYPTO 2022</i>, 13508:370–99. Springer Nature, 2022. <a href=\"https://doi.org/10.1007/978-3-031-15979-4_13\">https://doi.org/10.1007/978-3-031-15979-4_13</a>.","mla":"Hoffmann, Charlotte, et al. “Practical Statistically-Sound Proofs of Exponentiation in Any Group.” <i>Advances in Cryptology – CRYPTO 2022</i>, vol. 13508, Springer Nature, 2022, pp. 370–99, doi:<a href=\"https://doi.org/10.1007/978-3-031-15979-4_13\">10.1007/978-3-031-15979-4_13</a>.","ista":"Hoffmann C, Hubáček P, Kamath C, Klein K, Pietrzak KZ. 2022. Practical statistically-sound proofs of exponentiation in any group. Advances in Cryptology – CRYPTO 2022. CRYYPTO: International Cryptology Conference, LNCS, vol. 13508, 370–399.","ama":"Hoffmann C, Hubáček P, Kamath C, Klein K, Pietrzak KZ. Practical statistically-sound proofs of exponentiation in any group. In: <i>Advances in Cryptology – CRYPTO 2022</i>. Vol 13508. Springer Nature; 2022:370-399. doi:<a href=\"https://doi.org/10.1007/978-3-031-15979-4_13\">10.1007/978-3-031-15979-4_13</a>","short":"C. Hoffmann, P. Hubáček, C. Kamath, K. Klein, K.Z. Pietrzak, in:, Advances in Cryptology – CRYPTO 2022, Springer Nature, 2022, pp. 370–399.","ieee":"C. Hoffmann, P. Hubáček, C. Kamath, K. Klein, and K. Z. Pietrzak, “Practical statistically-sound proofs of exponentiation in any group,” in <i>Advances in Cryptology – CRYPTO 2022</i>, Santa Barbara, CA, United States, 2022, vol. 13508, pp. 370–399.","apa":"Hoffmann, C., Hubáček, P., Kamath, C., Klein, K., &#38; Pietrzak, K. Z. (2022). Practical statistically-sound proofs of exponentiation in any group. In <i>Advances in Cryptology – CRYPTO 2022</i> (Vol. 13508, pp. 370–399). Santa Barbara, CA, United States: Springer Nature. <a href=\"https://doi.org/10.1007/978-3-031-15979-4_13\">https://doi.org/10.1007/978-3-031-15979-4_13</a>"},"page":"370-399","date_updated":"2023-09-05T15:12:27Z","publication":"Advances in Cryptology – CRYPTO 2022","year":"2022","alternative_title":["LNCS"],"oa":1,"language":[{"iso":"eng"}],"quality_controlled":"1","type":"conference","isi":1,"main_file_link":[{"open_access":"1","url":"https://eprint.iacr.org/2022/1021"}],"intvolume":"     13508","publisher":"Springer Nature","scopus_import":"1","date_created":"2023-01-12T12:12:07Z","external_id":{"isi":["000886792700013"]},"date_published":"2022-10-13T00:00:00Z","user_id":"c635000d-4b10-11ee-a964-aac5a93f6ac1","department":[{"_id":"KrPi"}]},{"article_type":"original","page":"445-459","date_updated":"2023-01-26T13:04:13Z","publication":"Proceedings of the American Mathematical Society, Series B","year":"2022","oa":1,"type":"journal_article","language":[{"iso":"eng"}],"quality_controlled":"1","intvolume":"         9","publisher":"American Mathematical Society","scopus_import":"1","date_created":"2023-01-12T12:12:17Z","date_published":"2022-11-02T00:00:00Z","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","department":[{"_id":"JaMa"}],"ec_funded":1,"status":"public","publication_status":"published","acknowledgement":"The first author was partially supported by the National Science Foundation under Grant\r\nNo. DMS-1928930 while participating in a program hosted by the Mathematical Sciences Research Institute in Berkeley, California, during the Fall 2020 semester. The second author gratefully acknowledges funding by the Austrian Science Fund (FWF) through grants F65 and ESPRIT 208, by the European Research Council (ERC, grant No. 716117, awarded to Prof. Dr. Jan Maas), and by the Deutsche Forschungsgemeinschaft through the SPP 2265.","project":[{"grant_number":"F6504","_id":"fc31cba2-9c52-11eb-aca3-ff467d239cd2","name":"Taming Complexity in Partial Differential Systems"},{"_id":"256E75B8-B435-11E9-9278-68D0E5697425","grant_number":"716117","call_identifier":"H2020","name":"Optimal Transport and Stochastic Dynamics"}],"publication_identifier":{"issn":["2330-1511"]},"doi":"10.1090/bproc/134","issue":"43","abstract":[{"lang":"eng","text":"Using elementary hyperbolic geometry, we give an explicit formula for the contraction constant of the skinning map over moduli spaces of relatively acylindrical hyperbolic manifolds."}],"_id":"12177","author":[{"full_name":"Cremaschi, Tommaso","last_name":"Cremaschi","first_name":"Tommaso"},{"orcid":"0000-0002-9881-6870","first_name":"Lorenzo","id":"ECEBF480-9E4F-11EA-B557-B0823DDC885E","last_name":"Dello Schiavo","full_name":"Dello Schiavo, Lorenzo"}],"title":"Effective contraction of Skinning maps","article_processing_charge":"No","volume":9,"has_accepted_license":"1","tmp":{"name":"Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)","image":"/images/cc_by_nc_nd.png","short":"CC BY-NC-ND (4.0)","legal_code_url":"https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode"},"file":[{"relation":"main_file","creator":"dernst","file_size":326471,"file_name":"2022_ProceedingsAMS_Cremaschi.pdf","date_updated":"2023-01-26T13:02:07Z","success":1,"content_type":"application/pdf","checksum":"cb4a79937c1f60d4c329a10ee797f0d2","access_level":"open_access","date_created":"2023-01-26T13:02:07Z","file_id":"12404"}],"oa_version":"Published Version","month":"11","ddc":["510"],"file_date_updated":"2023-01-26T13:02:07Z","day":"02","citation":{"apa":"Cremaschi, T., &#38; Dello Schiavo, L. (2022). Effective contraction of Skinning maps. <i>Proceedings of the American Mathematical Society, Series B</i>. American Mathematical Society. <a href=\"https://doi.org/10.1090/bproc/134\">https://doi.org/10.1090/bproc/134</a>","ieee":"T. Cremaschi and L. Dello Schiavo, “Effective contraction of Skinning maps,” <i>Proceedings of the American Mathematical Society, Series B</i>, vol. 9, no. 43. American Mathematical Society, pp. 445–459, 2022.","short":"T. Cremaschi, L. Dello Schiavo, Proceedings of the American Mathematical Society, Series B 9 (2022) 445–459.","ama":"Cremaschi T, Dello Schiavo L. Effective contraction of Skinning maps. <i>Proceedings of the American Mathematical Society, Series B</i>. 2022;9(43):445-459. doi:<a href=\"https://doi.org/10.1090/bproc/134\">10.1090/bproc/134</a>","ista":"Cremaschi T, Dello Schiavo L. 2022. Effective contraction of Skinning maps. Proceedings of the American Mathematical Society, Series B. 9(43), 445–459.","chicago":"Cremaschi, Tommaso, and Lorenzo Dello Schiavo. “Effective Contraction of Skinning Maps.” <i>Proceedings of the American Mathematical Society, Series B</i>. American Mathematical Society, 2022. <a href=\"https://doi.org/10.1090/bproc/134\">https://doi.org/10.1090/bproc/134</a>.","mla":"Cremaschi, Tommaso, and Lorenzo Dello Schiavo. “Effective Contraction of Skinning Maps.” <i>Proceedings of the American Mathematical Society, Series B</i>, vol. 9, no. 43, American Mathematical Society, 2022, pp. 445–59, doi:<a href=\"https://doi.org/10.1090/bproc/134\">10.1090/bproc/134</a>."}},{"article_type":"original","publication":"Stochastics and Partial Differential Equations: Analysis and Computations","date_updated":"2023-08-16T09:11:38Z","year":"2022","keyword":["Applied Mathematics","Modeling and Simulation","Statistics and Probability"],"oa":1,"isi":1,"language":[{"iso":"eng"}],"type":"journal_article","quality_controlled":"1","main_file_link":[{"open_access":"1","url":"https://doi.org/10.1007/s40072-022-00277-3"}],"publisher":"Springer Nature","date_published":"2022-10-27T00:00:00Z","external_id":{"isi":["000874389000001"]},"scopus_import":"1","date_created":"2023-01-12T12:12:29Z","department":[{"_id":"JuFi"}],"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","acknowledgement":"The authors thank the anonymous referees for their helpful comments and suggestions. Open Access funding enabled and organized by Projekt DEAL.","publication_status":"epub_ahead","status":"public","publication_identifier":{"eissn":["2194-041X"],"issn":["2194-0401"]},"abstract":[{"lang":"eng","text":"In this paper we consider the stochastic primitive equation for geophysical flows subject to transport noise and turbulent pressure. Admitting very rough noise terms, the global existence and uniqueness of solutions to this stochastic partial differential equation are proven using stochastic maximal L² regularity, the theory of critical spaces for stochastic evolution equations, and global a priori bounds. Compared to other results in this direction, we do not need any smallness assumption on the transport noise which acts directly on the velocity field and we also allow rougher noise terms. The adaptation to Stratonovich type noise and, more generally, to variable viscosity and/or conductivity are discussed as well."}],"doi":"10.1007/s40072-022-00277-3","author":[{"orcid":"0000-0002-9573-2962","first_name":"Antonio","id":"673cd0cc-9b9a-11eb-b144-88f30e1fbb72","last_name":"Agresti","full_name":"Agresti, Antonio"},{"first_name":"Matthias","full_name":"Hieber, Matthias","last_name":"Hieber"},{"first_name":"Amru","last_name":"Hussein","full_name":"Hussein, Amru"},{"first_name":"Martin","last_name":"Saal","full_name":"Saal, Martin"}],"title":"The stochastic primitive equations with transport noise and turbulent pressure","_id":"12178","article_processing_charge":"Yes (via OA deal)","oa_version":"Published Version","day":"27","citation":{"ieee":"A. Agresti, M. Hieber, A. Hussein, and M. Saal, “The stochastic primitive equations with transport noise and turbulent pressure,” <i>Stochastics and Partial Differential Equations: Analysis and Computations</i>. Springer Nature, 2022.","apa":"Agresti, A., Hieber, M., Hussein, A., &#38; Saal, M. (2022). The stochastic primitive equations with transport noise and turbulent pressure. <i>Stochastics and Partial Differential Equations: Analysis and Computations</i>. Springer Nature. <a href=\"https://doi.org/10.1007/s40072-022-00277-3\">https://doi.org/10.1007/s40072-022-00277-3</a>","ama":"Agresti A, Hieber M, Hussein A, Saal M. The stochastic primitive equations with transport noise and turbulent pressure. <i>Stochastics and Partial Differential Equations: Analysis and Computations</i>. 2022. doi:<a href=\"https://doi.org/10.1007/s40072-022-00277-3\">10.1007/s40072-022-00277-3</a>","short":"A. Agresti, M. Hieber, A. Hussein, M. Saal, Stochastics and Partial Differential Equations: Analysis and Computations (2022).","ista":"Agresti A, Hieber M, Hussein A, Saal M. 2022. The stochastic primitive equations with transport noise and turbulent pressure. Stochastics and Partial Differential Equations: Analysis and Computations.","chicago":"Agresti, Antonio, Matthias Hieber, Amru Hussein, and Martin Saal. “The Stochastic Primitive Equations with Transport Noise and Turbulent Pressure.” <i>Stochastics and Partial Differential Equations: Analysis and Computations</i>. Springer Nature, 2022. <a href=\"https://doi.org/10.1007/s40072-022-00277-3\">https://doi.org/10.1007/s40072-022-00277-3</a>.","mla":"Agresti, Antonio, et al. “The Stochastic Primitive Equations with Transport Noise and Turbulent Pressure.” <i>Stochastics and Partial Differential Equations: Analysis and Computations</i>, Springer Nature, 2022, doi:<a href=\"https://doi.org/10.1007/s40072-022-00277-3\">10.1007/s40072-022-00277-3</a>."},"month":"10"},{"volume":43,"article_processing_charge":"No","arxiv":1,"oa_version":"Preprint","day":"01","citation":{"ista":"Cipolloni G, Erdös L, Schröder DJ. 2022. On the condition number of the shifted real Ginibre ensemble. SIAM Journal on Matrix Analysis and Applications. 43(3), 1469–1487.","ama":"Cipolloni G, Erdös L, Schröder DJ. On the condition number of the shifted real Ginibre ensemble. <i>SIAM Journal on Matrix Analysis and Applications</i>. 2022;43(3):1469-1487. doi:<a href=\"https://doi.org/10.1137/21m1424408\">10.1137/21m1424408</a>","short":"G. Cipolloni, L. Erdös, D.J. Schröder, SIAM Journal on Matrix Analysis and Applications 43 (2022) 1469–1487.","apa":"Cipolloni, G., Erdös, L., &#38; Schröder, D. J. (2022). On the condition number of the shifted real Ginibre ensemble. <i>SIAM Journal on Matrix Analysis and Applications</i>. Society for Industrial and Applied Mathematics. <a href=\"https://doi.org/10.1137/21m1424408\">https://doi.org/10.1137/21m1424408</a>","ieee":"G. Cipolloni, L. Erdös, and D. J. Schröder, “On the condition number of the shifted real Ginibre ensemble,” <i>SIAM Journal on Matrix Analysis and Applications</i>, vol. 43, no. 3. Society for Industrial and Applied Mathematics, pp. 1469–1487, 2022.","mla":"Cipolloni, Giorgio, et al. “On the Condition Number of the Shifted Real Ginibre Ensemble.” <i>SIAM Journal on Matrix Analysis and Applications</i>, vol. 43, no. 3, Society for Industrial and Applied Mathematics, 2022, pp. 1469–87, doi:<a href=\"https://doi.org/10.1137/21m1424408\">10.1137/21m1424408</a>.","chicago":"Cipolloni, Giorgio, László Erdös, and Dominik J Schröder. “On the Condition Number of the Shifted Real Ginibre Ensemble.” <i>SIAM Journal on Matrix Analysis and Applications</i>. Society for Industrial and Applied Mathematics, 2022. <a href=\"https://doi.org/10.1137/21m1424408\">https://doi.org/10.1137/21m1424408</a>."},"month":"07","status":"public","publication_status":"published","publication_identifier":{"eissn":["1095-7162"],"issn":["0895-4798"]},"issue":"3","abstract":[{"text":"We derive an accurate lower tail estimate on the lowest singular value σ1(X−z) of a real Gaussian (Ginibre) random matrix X shifted by a complex parameter z. Such shift effectively changes the upper tail behavior of the condition number κ(X−z) from the slower (κ(X−z)≥t)≲1/t decay typical for real Ginibre matrices to the faster 1/t2 decay seen for complex Ginibre matrices as long as z is away from the real axis. This sharpens and resolves a recent conjecture in [J. Banks et al., https://arxiv.org/abs/2005.08930, 2020] on the regularizing effect of the real Ginibre ensemble with a genuinely complex shift. As a consequence we obtain an improved upper bound on the eigenvalue condition numbers (known also as the eigenvector overlaps) for real Ginibre matrices. The main technical tool is a rigorous supersymmetric analysis from our earlier work [Probab. Math. Phys., 1 (2020), pp. 101--146].","lang":"eng"}],"doi":"10.1137/21m1424408","author":[{"orcid":"0000-0002-4901-7992","first_name":"Giorgio","id":"42198EFA-F248-11E8-B48F-1D18A9856A87","last_name":"Cipolloni","full_name":"Cipolloni, Giorgio"},{"full_name":"Erdös, László","last_name":"Erdös","id":"4DBD5372-F248-11E8-B48F-1D18A9856A87","first_name":"László","orcid":"0000-0001-5366-9603"},{"orcid":"0000-0002-2904-1856","full_name":"Schröder, Dominik J","last_name":"Schröder","id":"408ED176-F248-11E8-B48F-1D18A9856A87","first_name":"Dominik J"}],"title":"On the condition number of the shifted real Ginibre ensemble","_id":"12179","language":[{"iso":"eng"}],"quality_controlled":"1","type":"journal_article","main_file_link":[{"open_access":"1","url":"https://doi.org/10.48550/arXiv.2105.13719"}],"intvolume":"        43","publisher":"Society for Industrial and Applied Mathematics","external_id":{"arxiv":["2105.13719"]},"date_published":"2022-07-01T00:00:00Z","scopus_import":"1","date_created":"2023-01-12T12:12:38Z","department":[{"_id":"LaEr"}],"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","article_type":"original","page":"1469-1487","publication":"SIAM Journal on Matrix Analysis and Applications","date_updated":"2023-01-27T06:56:06Z","year":"2022","keyword":["Analysis"],"oa":1},{"article_number":"52","publication":"36th International Symposium on Distributed Computing","date_updated":"2023-01-27T06:59:29Z","year":"2022","oa":1,"quality_controlled":"1","language":[{"iso":"eng"}],"type":"conference","intvolume":"       246","publisher":"Schloss Dagstuhl - Leibniz-Zentrum für Informatik","date_published":"2022-10-17T00:00:00Z","scopus_import":"1","date_created":"2023-01-13T11:06:28Z","department":[{"_id":"DaAl"}],"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","acknowledgement":"This research has received funding from the German Research Foundation (DFG), grant\r\n470029389 (FlexNets), 2021-2024, and the Marie Skłodowska-Curie grant agreement No. 840605.","publication_status":"published","status":"public","ec_funded":1,"publication_identifier":{"eissn":["1868-8969"],"eisbn":["9783959772556"]},"project":[{"name":"Coordination in constrained and natural distributed systems","call_identifier":"H2020","_id":"26A5D39A-B435-11E9-9278-68D0E5697425","grant_number":"840605"}],"abstract":[{"lang":"eng","text":"Online algorithms make decisions based on past inputs, with the goal of being competitive against an algorithm that sees also future inputs. In this work, we introduce time-local online algorithms; these are online algorithms in which the output at any given time is a function of only T latest inputs. Our main observation is that time-local online algorithms are closely connected to local distributed graph algorithms: distributed algorithms make decisions based on the local information in the spatial dimension, while time-local online algorithms make decisions based on the local information in the temporal dimension. We formalize this connection, and show how we can directly use the tools developed to study distributed approximability of graph optimization problems to prove upper and lower bounds on the competitive ratio achieved with time-local online algorithms. Moreover, we show how to use computational techniques to synthesize optimal time-local algorithms."}],"doi":"10.4230/LIPIcs.DISC.2022.52","author":[{"full_name":"Pacut, Maciej","last_name":"Pacut","first_name":"Maciej"},{"last_name":"Parham","full_name":"Parham, Mahmoud","first_name":"Mahmoud"},{"orcid":"0000-0002-6432-6646","id":"334EFD2E-F248-11E8-B48F-1D18A9856A87","first_name":"Joel","full_name":"Rybicki, Joel","last_name":"Rybicki"},{"first_name":"Stefan","full_name":"Schmid, Stefan","last_name":"Schmid"},{"full_name":"Suomela, Jukka","last_name":"Suomela","first_name":"Jukka"},{"last_name":"Tereshchenko","full_name":"Tereshchenko, Aleksandr","first_name":"Aleksandr"}],"title":"Brief announcement: Temporal locality in online algorithms","_id":"12182","has_accepted_license":"1","volume":246,"article_processing_charge":"No","file":[{"file_name":"2022_LIPICs_Pacut.pdf","file_size":524804,"relation":"main_file","creator":"dernst","success":1,"date_updated":"2023-01-27T06:58:02Z","access_level":"open_access","content_type":"application/pdf","checksum":"11bbb56f68a00f2cf6bcce6cc7f5c5f9","file_id":"12409","date_created":"2023-01-27T06:58:02Z"}],"tmp":{"name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","image":"/images/cc_by.png","short":"CC BY (4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode"},"conference":{"name":"DISC: Symposium on Distributed Computing","end_date":"2022-10-27","location":"Augusta, GA, United States","start_date":"2022-10-25"},"oa_version":"Published Version","day":"17","citation":{"apa":"Pacut, M., Parham, M., Rybicki, J., Schmid, S., Suomela, J., &#38; Tereshchenko, A. (2022). Brief announcement: Temporal locality in online algorithms. In <i>36th International Symposium on Distributed Computing</i> (Vol. 246). Augusta, GA, United States: Schloss Dagstuhl - Leibniz-Zentrum für Informatik. <a href=\"https://doi.org/10.4230/LIPIcs.DISC.2022.52\">https://doi.org/10.4230/LIPIcs.DISC.2022.52</a>","ieee":"M. Pacut, M. Parham, J. Rybicki, S. Schmid, J. Suomela, and A. Tereshchenko, “Brief announcement: Temporal locality in online algorithms,” in <i>36th International Symposium on Distributed Computing</i>, Augusta, GA, United States, 2022, vol. 246.","ama":"Pacut M, Parham M, Rybicki J, Schmid S, Suomela J, Tereshchenko A. Brief announcement: Temporal locality in online algorithms. In: <i>36th International Symposium on Distributed Computing</i>. Vol 246. Schloss Dagstuhl - Leibniz-Zentrum für Informatik; 2022. doi:<a href=\"https://doi.org/10.4230/LIPIcs.DISC.2022.52\">10.4230/LIPIcs.DISC.2022.52</a>","ista":"Pacut M, Parham M, Rybicki J, Schmid S, Suomela J, Tereshchenko A. 2022. Brief announcement: Temporal locality in online algorithms. 36th International Symposium on Distributed Computing. DISC: Symposium on Distributed Computing vol. 246, 52.","short":"M. Pacut, M. Parham, J. Rybicki, S. Schmid, J. Suomela, A. Tereshchenko, in:, 36th International Symposium on Distributed Computing, Schloss Dagstuhl - Leibniz-Zentrum für Informatik, 2022.","mla":"Pacut, Maciej, et al. “Brief Announcement: Temporal Locality in Online Algorithms.” <i>36th International Symposium on Distributed Computing</i>, vol. 246, 52, Schloss Dagstuhl - Leibniz-Zentrum für Informatik, 2022, doi:<a href=\"https://doi.org/10.4230/LIPIcs.DISC.2022.52\">10.4230/LIPIcs.DISC.2022.52</a>.","chicago":"Pacut, Maciej, Mahmoud Parham, Joel Rybicki, Stefan Schmid, Jukka Suomela, and Aleksandr Tereshchenko. “Brief Announcement: Temporal Locality in Online Algorithms.” In <i>36th International Symposium on Distributed Computing</i>, Vol. 246. Schloss Dagstuhl - Leibniz-Zentrum für Informatik, 2022. <a href=\"https://doi.org/10.4230/LIPIcs.DISC.2022.52\">https://doi.org/10.4230/LIPIcs.DISC.2022.52</a>."},"file_date_updated":"2023-01-27T06:58:02Z","ddc":["000"],"month":"10"},{"publication_identifier":{"issn":["0022-2488"]},"project":[{"grant_number":"101020331","_id":"62796744-2b32-11ec-9570-940b20777f1d","call_identifier":"H2020","name":"Random matrices beyond Wigner-Dyson-Mehta"}],"publication_status":"published","acknowledgement":"It is a pleasure to thank Stefan Teufel for numerous interesting discussions, fruitful collaboration, and many helpful comments on an earlier version of the manuscript. J.H. acknowledges partial financial support from the ERC Advanced Grant No. 101020331 “Random\r\nmatrices beyond Wigner-Dyson-Mehta.” T.W. acknowledges financial support from the DFG research unit FOR 5413 “Long-range interacting quantum spin systems out of equilibrium: Experiment, Theory and Mathematics.\" ","status":"public","ec_funded":1,"author":[{"full_name":"Henheik, Sven Joscha","last_name":"Henheik","id":"31d731d7-d235-11ea-ad11-b50331c8d7fb","first_name":"Sven Joscha","orcid":"0000-0003-1106-327X"},{"last_name":"Wessel","full_name":"Wessel, Tom","first_name":"Tom"}],"title":"On adiabatic theory for extended fermionic lattice systems","_id":"12184","issue":"12","abstract":[{"lang":"eng","text":"We review recent results on adiabatic theory for ground states of extended gapped fermionic lattice systems under several different assumptions. More precisely, we present generalized super-adiabatic theorems for extended but finite and infinite systems, assuming either a uniform gap or a gap in the bulk above the unperturbed ground state. The goal of this Review is to provide an overview of these adiabatic theorems and briefly outline the main ideas and techniques required in their proofs."}],"doi":"10.1063/5.0123441","tmp":{"name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","image":"/images/cc_by.png","short":"CC BY (4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode"},"file":[{"file_size":5251092,"relation":"main_file","creator":"dernst","file_name":"2022_JourMathPhysics_Henheik2.pdf","date_updated":"2023-01-27T07:10:52Z","success":1,"checksum":"213b93750080460718c050e4967cfdb4","content_type":"application/pdf","access_level":"open_access","date_created":"2023-01-27T07:10:52Z","file_id":"12410"}],"arxiv":1,"has_accepted_license":"1","volume":63,"article_processing_charge":"No","day":"01","citation":{"ista":"Henheik SJ, Wessel T. 2022. On adiabatic theory for extended fermionic lattice systems. Journal of Mathematical Physics. 63(12), 121101.","ama":"Henheik SJ, Wessel T. On adiabatic theory for extended fermionic lattice systems. <i>Journal of Mathematical Physics</i>. 2022;63(12). doi:<a href=\"https://doi.org/10.1063/5.0123441\">10.1063/5.0123441</a>","short":"S.J. Henheik, T. Wessel, Journal of Mathematical Physics 63 (2022).","apa":"Henheik, S. J., &#38; Wessel, T. (2022). On adiabatic theory for extended fermionic lattice systems. <i>Journal of Mathematical Physics</i>. AIP Publishing. <a href=\"https://doi.org/10.1063/5.0123441\">https://doi.org/10.1063/5.0123441</a>","ieee":"S. J. Henheik and T. Wessel, “On adiabatic theory for extended fermionic lattice systems,” <i>Journal of Mathematical Physics</i>, vol. 63, no. 12. AIP Publishing, 2022.","chicago":"Henheik, Sven Joscha, and Tom Wessel. “On Adiabatic Theory for Extended Fermionic Lattice Systems.” <i>Journal of Mathematical Physics</i>. AIP Publishing, 2022. <a href=\"https://doi.org/10.1063/5.0123441\">https://doi.org/10.1063/5.0123441</a>.","mla":"Henheik, Sven Joscha, and Tom Wessel. “On Adiabatic Theory for Extended Fermionic Lattice Systems.” <i>Journal of Mathematical Physics</i>, vol. 63, no. 12, 121101, AIP Publishing, 2022, doi:<a href=\"https://doi.org/10.1063/5.0123441\">10.1063/5.0123441</a>."},"ddc":["510"],"file_date_updated":"2023-01-27T07:10:52Z","month":"12","oa_version":"Published Version","publication":"Journal of Mathematical Physics","date_updated":"2023-08-04T09:14:57Z","article_type":"original","article_number":"121101","oa":1,"year":"2022","intvolume":"        63","publisher":"AIP Publishing","isi":1,"type":"journal_article","language":[{"iso":"eng"}],"quality_controlled":"1","department":[{"_id":"LaEr"}],"user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","date_published":"2022-12-01T00:00:00Z","external_id":{"arxiv":["2208.12220"],"isi":["000905776200001"]},"scopus_import":"1","date_created":"2023-01-15T23:00:52Z"},{"oa":1,"keyword":["General Physics and Astronomy","General Biochemistry","Genetics and Molecular Biology","General Chemistry","Multidisciplinary"],"year":"2022","date_updated":"2023-08-04T09:15:31Z","publication":"Nature Communications","article_number":"6326","article_type":"original","user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","department":[{"_id":"StFr"}],"date_created":"2023-01-16T09:45:09Z","scopus_import":"1","date_published":"2022-10-24T00:00:00Z","external_id":{"pmid":["36280671"],"isi":["000871563700006"]},"publisher":"Springer Nature","intvolume":"        13","quality_controlled":"1","language":[{"iso":"eng"}],"type":"journal_article","isi":1,"_id":"12208","title":"On the nanoscale structural evolution of solid discharge products in lithium-sulfur batteries using operando scattering","author":[{"full_name":"Prehal, Christian","last_name":"Prehal","first_name":"Christian"},{"first_name":"Jean-Marc","full_name":"von Mentlen, Jean-Marc","last_name":"von Mentlen"},{"first_name":"Sara","last_name":"Drvarič Talian","full_name":"Drvarič Talian, Sara"},{"first_name":"Alen","full_name":"Vizintin, Alen","last_name":"Vizintin"},{"last_name":"Dominko","full_name":"Dominko, Robert","first_name":"Robert"},{"first_name":"Heinz","last_name":"Amenitsch","full_name":"Amenitsch, Heinz"},{"last_name":"Porcar","full_name":"Porcar, Lionel","first_name":"Lionel"},{"orcid":"0000-0003-2902-5319","first_name":"Stefan Alexander","id":"A8CA28E6-CE23-11E9-AD2D-EC27E6697425","last_name":"Freunberger","full_name":"Freunberger, Stefan Alexander"},{"full_name":"Wood, Vanessa","last_name":"Wood","first_name":"Vanessa"}],"doi":"10.1038/s41467-022-33931-4","abstract":[{"text":"The inadequate understanding of the mechanisms that reversibly convert molecular sulfur (S) into lithium sulfide (Li<jats:sub>2</jats:sub>S) via soluble polysulfides (PSs) formation impedes the development of high-performance lithium-sulfur (Li-S) batteries with non-aqueous electrolyte solutions. Here, we use operando small and wide angle X-ray scattering and operando small angle neutron scattering (SANS) measurements to track the nucleation, growth and dissolution of solid deposits from atomic to sub-micron scales during real-time Li-S cell operation. In particular, stochastic modelling based on the SANS data allows quantifying the nanoscale phase evolution during battery cycling. We show that next to nano-crystalline Li<jats:sub>2</jats:sub>S the deposit comprises solid short-chain PSs particles. The analysis of the experimental data suggests that initially, Li<jats:sub>2</jats:sub>S<jats:sub>2</jats:sub> precipitates from the solution and then is partially converted via solid-state electroreduction to Li<jats:sub>2</jats:sub>S. We further demonstrate that mass transport, rather than electron transport through a thin passivating film, limits the discharge capacity and rate performance in Li-S cells.","lang":"eng"}],"publication_identifier":{"issn":["2041-1723"]},"acknowledgement":"This project has received funding from the European Union’s Horizon 2020 research and innovation program under the Marie Skłodowska-Curie grant NanoEvolution, grant agreement No 894042. The authors acknowledge the CERIC-ERIC Consortium for the access to the Austrian SAXS beamline and TU Graz for support through the Lead Project LP-03.\r\nLikewise, the use of SOMAPP Lab, a core facility supported by the Austrian Federal Ministry of Education, Science and Research, the Graz University of Technology, the University of Graz, and Anton Paar GmbH is acknowledged. In addition, the authors acknowledge access to the D-22SANS beamline at the ILL neutron source. Electron microscopy measurements were performed at the Scientific Scenter for Optical and Electron Microscopy (ScopeM) of the Swiss Federal Institute of Technology. C.P. and J.M.M. thank A. Senol for her support with the SANS\r\nbeamtime preparation. S.D.T, A.V. and R.D. acknowledge the financial support by the Slovenian Research Agency (ARRS) research core funding P2-0393 and P2-0423. Furthermore, A.V. acknowledge the funding from the Slovenian Research Agency, research project Z2−1863.\r\nS.A.F. is indebted to IST Austria for support. ","publication_status":"published","status":"public","pmid":1,"file_date_updated":"2023-01-27T07:19:11Z","month":"10","ddc":["540"],"citation":{"chicago":"Prehal, Christian, Jean-Marc von Mentlen, Sara Drvarič Talian, Alen Vizintin, Robert Dominko, Heinz Amenitsch, Lionel Porcar, Stefan Alexander Freunberger, and Vanessa Wood. “On the Nanoscale Structural Evolution of Solid Discharge Products in Lithium-Sulfur Batteries Using Operando Scattering.” <i>Nature Communications</i>. Springer Nature, 2022. <a href=\"https://doi.org/10.1038/s41467-022-33931-4\">https://doi.org/10.1038/s41467-022-33931-4</a>.","mla":"Prehal, Christian, et al. “On the Nanoscale Structural Evolution of Solid Discharge Products in Lithium-Sulfur Batteries Using Operando Scattering.” <i>Nature Communications</i>, vol. 13, 6326, Springer Nature, 2022, doi:<a href=\"https://doi.org/10.1038/s41467-022-33931-4\">10.1038/s41467-022-33931-4</a>.","ieee":"C. Prehal <i>et al.</i>, “On the nanoscale structural evolution of solid discharge products in lithium-sulfur batteries using operando scattering,” <i>Nature Communications</i>, vol. 13. Springer Nature, 2022.","apa":"Prehal, C., von Mentlen, J.-M., Drvarič Talian, S., Vizintin, A., Dominko, R., Amenitsch, H., … Wood, V. (2022). On the nanoscale structural evolution of solid discharge products in lithium-sulfur batteries using operando scattering. <i>Nature Communications</i>. Springer Nature. <a href=\"https://doi.org/10.1038/s41467-022-33931-4\">https://doi.org/10.1038/s41467-022-33931-4</a>","short":"C. Prehal, J.-M. von Mentlen, S. Drvarič Talian, A. Vizintin, R. Dominko, H. Amenitsch, L. Porcar, S.A. Freunberger, V. Wood, Nature Communications 13 (2022).","ista":"Prehal C, von Mentlen J-M, Drvarič Talian S, Vizintin A, Dominko R, Amenitsch H, Porcar L, Freunberger SA, Wood V. 2022. On the nanoscale structural evolution of solid discharge products in lithium-sulfur batteries using operando scattering. Nature Communications. 13, 6326.","ama":"Prehal C, von Mentlen J-M, Drvarič Talian S, et al. On the nanoscale structural evolution of solid discharge products in lithium-sulfur batteries using operando scattering. <i>Nature Communications</i>. 2022;13. doi:<a href=\"https://doi.org/10.1038/s41467-022-33931-4\">10.1038/s41467-022-33931-4</a>"},"day":"24","oa_version":"Published Version","tmp":{"name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","image":"/images/cc_by.png","short":"CC BY (4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode"},"file":[{"date_created":"2023-01-27T07:19:11Z","file_id":"12411","creator":"dernst","file_size":4216931,"relation":"main_file","file_name":"2022_NatureCommunications_Prehal.pdf","date_updated":"2023-01-27T07:19:11Z","success":1,"content_type":"application/pdf","checksum":"5034336dbf0f860030ef745c08df9e0e","access_level":"open_access"}],"article_processing_charge":"No","volume":13,"has_accepted_license":"1"},{"_id":"12209","author":[{"orcid":"0000-0003-4333-7503","full_name":"Nunes Pinheiro, Diana C","last_name":"Nunes Pinheiro","id":"2E839F16-F248-11E8-B48F-1D18A9856A87","first_name":"Diana C"},{"full_name":"Kardos, Roland","last_name":"Kardos","id":"4039350E-F248-11E8-B48F-1D18A9856A87","first_name":"Roland"},{"first_name":"Edouard B","id":"3A9DB764-F248-11E8-B48F-1D18A9856A87","last_name":"Hannezo","full_name":"Hannezo, Edouard B","orcid":"0000-0001-6005-1561"},{"last_name":"Heisenberg","full_name":"Heisenberg, Carl-Philipp J","first_name":"Carl-Philipp J","id":"39427864-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-0912-4566"}],"title":"Morphogen gradient orchestrates pattern-preserving tissue morphogenesis via motility-driven unjamming","doi":"10.1038/s41567-022-01787-6","issue":"12","abstract":[{"lang":"eng","text":"Embryo development requires biochemical signalling to generate patterns of cell fates and active mechanical forces to drive tissue shape changes. However, how these processes are coordinated, and how tissue patterning is preserved despite the cellular flows occurring during morphogenesis, remains poorly understood. Gastrulation is a crucial embryonic stage that involves both patterning and internalization of the mesendoderm germ layer tissue. Here we show that, in zebrafish embryos, a gradient in Nodal signalling orchestrates pattern-preserving internalization movements by triggering a motility-driven unjamming transition. In addition to its role as a morphogen determining embryo patterning, graded Nodal signalling mechanically subdivides the mesendoderm into a small fraction of highly protrusive leader cells, able to autonomously internalize via local unjamming, and less protrusive followers, which need to be pulled inwards by the leaders. The Nodal gradient further enforces a code of preferential adhesion coupling leaders to their immediate followers, resulting in a collective and ordered mode of internalization that preserves mesendoderm patterning. Integrating this dual mechanical role of Nodal signalling into minimal active particle simulations quantitatively predicts both physiological and experimentally perturbed internalization movements. This provides a quantitative framework for how a morphogen-encoded unjamming transition can bidirectionally couple tissue mechanics with patterning during complex three-dimensional morphogenesis."}],"project":[{"_id":"26520D1E-B435-11E9-9278-68D0E5697425","grant_number":"ALTF 850-2017","name":"Coordination of mesendoderm cell fate specification and internalization during zebrafish gastrulation"},{"name":"Coordination of mesendoderm cell fate specification and internalization during zebrafish gastrulation","_id":"26520D1E-B435-11E9-9278-68D0E5697425","grant_number":"ALTF 850-2017"},{"_id":"05943252-7A3F-11EA-A408-12923DDC885E","grant_number":"851288","name":"Design Principles of Branching Morphogenesis","call_identifier":"H2020"},{"_id":"260F1432-B435-11E9-9278-68D0E5697425","grant_number":"742573","name":"Interaction and feedback between cell mechanics and fate specification in vertebrate gastrulation","call_identifier":"H2020"}],"publication_identifier":{"issn":["1745-2473"],"eissn":["1745-2481"]},"ec_funded":1,"status":"public","acknowledgement":"We thank K. Sampath, A. Pauli and Y. Bellaїche for feedback on the manuscript. We also thank the members of the Heisenberg group, in particular A. Schauer and F. Nur Arslan, for help, technical advice and discussions, and the Bioimaging and Life Science facilities at IST\r\nAustria for continuous support. We thank C. Flandoli for the artwork in the figures. This work was supported by postdoctoral fellowships from EMBO (LTF-850-2017) and HFSP (LT000429/2018-L2) to D.P. and the European Union (European Research Council starting grant 851288 to É.H. and European Research Council advanced grant 742573 to C.-P.H.).","publication_status":"published","month":"12","file_date_updated":"2023-01-27T07:32:01Z","ddc":["570"],"day":"01","citation":{"ieee":"D. C. Nunes Pinheiro, R. Kardos, E. B. Hannezo, and C.-P. J. Heisenberg, “Morphogen gradient orchestrates pattern-preserving tissue morphogenesis via motility-driven unjamming,” <i>Nature Physics</i>, vol. 18, no. 12. Springer Nature, pp. 1482–1493, 2022.","apa":"Nunes Pinheiro, D. C., Kardos, R., Hannezo, E. B., &#38; Heisenberg, C.-P. J. (2022). Morphogen gradient orchestrates pattern-preserving tissue morphogenesis via motility-driven unjamming. <i>Nature Physics</i>. Springer Nature. <a href=\"https://doi.org/10.1038/s41567-022-01787-6\">https://doi.org/10.1038/s41567-022-01787-6</a>","short":"D.C. Nunes Pinheiro, R. Kardos, E.B. Hannezo, C.-P.J. Heisenberg, Nature Physics 18 (2022) 1482–1493.","ama":"Nunes Pinheiro DC, Kardos R, Hannezo EB, Heisenberg C-PJ. Morphogen gradient orchestrates pattern-preserving tissue morphogenesis via motility-driven unjamming. <i>Nature Physics</i>. 2022;18(12):1482-1493. doi:<a href=\"https://doi.org/10.1038/s41567-022-01787-6\">10.1038/s41567-022-01787-6</a>","ista":"Nunes Pinheiro DC, Kardos R, Hannezo EB, Heisenberg C-PJ. 2022. Morphogen gradient orchestrates pattern-preserving tissue morphogenesis via motility-driven unjamming. Nature Physics. 18(12), 1482–1493.","mla":"Nunes Pinheiro, Diana C., et al. “Morphogen Gradient Orchestrates Pattern-Preserving Tissue Morphogenesis via Motility-Driven Unjamming.” <i>Nature Physics</i>, vol. 18, no. 12, Springer Nature, 2022, pp. 1482–93, doi:<a href=\"https://doi.org/10.1038/s41567-022-01787-6\">10.1038/s41567-022-01787-6</a>.","chicago":"Nunes Pinheiro, Diana C, Roland Kardos, Edouard B Hannezo, and Carl-Philipp J Heisenberg. “Morphogen Gradient Orchestrates Pattern-Preserving Tissue Morphogenesis via Motility-Driven Unjamming.” <i>Nature Physics</i>. Springer Nature, 2022. <a href=\"https://doi.org/10.1038/s41567-022-01787-6\">https://doi.org/10.1038/s41567-022-01787-6</a>."},"oa_version":"Published Version","file":[{"checksum":"c86a8e8d80d1bfc46d56a01e88a2526a","content_type":"application/pdf","access_level":"open_access","date_updated":"2023-01-27T07:32:01Z","success":1,"file_size":36703569,"creator":"dernst","relation":"main_file","file_name":"2022_NaturePhysics_Pinheiro.pdf","date_created":"2023-01-27T07:32:01Z","file_id":"12412"}],"tmp":{"name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","image":"/images/cc_by.png","short":"CC BY (4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode"},"article_processing_charge":"No","volume":18,"has_accepted_license":"1","oa":1,"keyword":["General Physics and Astronomy"],"year":"2022","date_updated":"2023-08-04T09:15:58Z","publication":"Nature Physics","article_type":"original","page":"1482-1493","user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","department":[{"_id":"CaHe"},{"_id":"EdHa"}],"acknowledged_ssus":[{"_id":"Bio"},{"_id":"LifeSc"}],"scopus_import":"1","date_created":"2023-01-16T09:45:19Z","date_published":"2022-12-01T00:00:00Z","external_id":{"isi":["000871319900002"]},"intvolume":"        18","publisher":"Springer Nature","type":"journal_article","language":[{"iso":"eng"}],"quality_controlled":"1","isi":1},{"publisher":"Springer Nature","main_file_link":[{"open_access":"1","url":"https://arxiv.org/abs/2101.00584"}],"intvolume":"       302","isi":1,"language":[{"iso":"eng"}],"type":"journal_article","quality_controlled":"1","department":[{"_id":"JaMa"}],"user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","external_id":{"arxiv":["2101.00584"],"isi":["000859680700001"]},"date_published":"2022-12-01T00:00:00Z","date_created":"2023-01-16T09:45:31Z","scopus_import":"1","publication":"Mathematische Zeitschrift","date_updated":"2023-08-04T09:22:14Z","page":"2327-2352","article_type":"original","oa":1,"year":"2022","keyword":["General Mathematics"],"arxiv":1,"volume":302,"article_processing_charge":"No","citation":{"mla":"Akylzhanov, Rauan, et al. “Norms of Certain Functions of a Distinguished Laplacian on the Ax + b Groups.” <i>Mathematische Zeitschrift</i>, vol. 302, no. 4, Springer Nature, 2022, pp. 2327–52, doi:<a href=\"https://doi.org/10.1007/s00209-022-03143-z\">10.1007/s00209-022-03143-z</a>.","chicago":"Akylzhanov, Rauan, Yulia Kuznetsova, Michael Ruzhansky, and Haonan Zhang. “Norms of Certain Functions of a Distinguished Laplacian on the Ax + b Groups.” <i>Mathematische Zeitschrift</i>. Springer Nature, 2022. <a href=\"https://doi.org/10.1007/s00209-022-03143-z\">https://doi.org/10.1007/s00209-022-03143-z</a>.","ama":"Akylzhanov R, Kuznetsova Y, Ruzhansky M, Zhang H. Norms of certain functions of a distinguished Laplacian on the ax + b groups. <i>Mathematische Zeitschrift</i>. 2022;302(4):2327-2352. doi:<a href=\"https://doi.org/10.1007/s00209-022-03143-z\">10.1007/s00209-022-03143-z</a>","ista":"Akylzhanov R, Kuznetsova Y, Ruzhansky M, Zhang H. 2022. Norms of certain functions of a distinguished Laplacian on the ax + b groups. Mathematische Zeitschrift. 302(4), 2327–2352.","short":"R. Akylzhanov, Y. Kuznetsova, M. Ruzhansky, H. Zhang, Mathematische Zeitschrift 302 (2022) 2327–2352.","apa":"Akylzhanov, R., Kuznetsova, Y., Ruzhansky, M., &#38; Zhang, H. (2022). Norms of certain functions of a distinguished Laplacian on the ax + b groups. <i>Mathematische Zeitschrift</i>. Springer Nature. <a href=\"https://doi.org/10.1007/s00209-022-03143-z\">https://doi.org/10.1007/s00209-022-03143-z</a>","ieee":"R. Akylzhanov, Y. Kuznetsova, M. Ruzhansky, and H. Zhang, “Norms of certain functions of a distinguished Laplacian on the ax + b groups,” <i>Mathematische Zeitschrift</i>, vol. 302, no. 4. Springer Nature, pp. 2327–2352, 2022."},"day":"01","month":"12","oa_version":"Preprint","publication_identifier":{"eissn":["1432-1823"],"issn":["0025-5874"]},"project":[{"grant_number":"754411","_id":"260C2330-B435-11E9-9278-68D0E5697425","call_identifier":"H2020","name":"ISTplus - Postdoctoral Fellowships"},{"grant_number":"M03337","_id":"eb958bca-77a9-11ec-83b8-c565cb50d8d6","name":"Curvature-dimension in noncommutative analysis"}],"publication_status":"published","status":"public","acknowledgement":"Yu. K. thanks Professor Waldemar Hebisch for valuable discussions on the general context of multipliers on Lie groups. This work was started during an ICL-CNRS fellowship of the second\r\nnamed author at the Imperial College London. Yu. K. is supported by the ANR-19-CE40-0002 grant of the French National Research Agency (ANR). H. Z. is supported by the European Union’s Horizon 2020 research and innovation programme under the Marie Skłodowska-Curie grant agreement No. 754411 and the Lise Meitner fellowship, Austrian Science Fund (FWF) M3337. R. A. was supported by the EPSRC grant EP/R003025. M. R. is supported by the EPSRC grant EP/R003025/2 and by the FWO Odysseus 1 grant G.0H94.18N: Analysis and Partial Differential Equations.","ec_funded":1,"title":"Norms of certain functions of a distinguished Laplacian on the ax + b groups","author":[{"last_name":"Akylzhanov","full_name":"Akylzhanov, Rauan","first_name":"Rauan"},{"first_name":"Yulia","full_name":"Kuznetsova, Yulia","last_name":"Kuznetsova"},{"first_name":"Michael","last_name":"Ruzhansky","full_name":"Ruzhansky, Michael"},{"id":"D8F41E38-9E66-11E9-A9E2-65C2E5697425","first_name":"Haonan","full_name":"Zhang, Haonan","last_name":"Zhang"}],"_id":"12210","abstract":[{"lang":"eng","text":"The aim of this paper is to find new estimates for the norms of functions of a (minus) distinguished Laplace operator L on the ‘ax+b’ groups. The central part is devoted to spectrally localized wave propagators, that is, functions of the type ψ(L−−√)exp(itL−−√), with ψ∈C0(R). We show that for t→+∞, the convolution kernel kt of this operator satisfies\r\n∥kt∥1≍t,∥kt∥∞≍1,\r\nso that the upper estimates of D. Müller and C. Thiele (Studia Math., 2007) are sharp. As a necessary component, we recall the Plancherel density of L and spend certain time presenting and comparing different approaches to its calculation. Using its explicit form, we estimate uniform norms of several functions of the shifted Laplace-Beltrami operator Δ~, closely related to L. The functions include in particular exp(−tΔ~γ), t>0,γ>0, and (Δ~−z)s, with complex z, s."}],"issue":"4","doi":"10.1007/s00209-022-03143-z"},{"publisher":"Springer Nature","intvolume":"        14","quality_controlled":"1","type":"journal_article","language":[{"iso":"eng"}],"isi":1,"user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","department":[{"_id":"RySh"}],"date_created":"2023-01-16T09:45:51Z","scopus_import":"1","date_published":"2022-09-21T00:00:00Z","external_id":{"isi":["000857985500001"]},"date_updated":"2023-08-04T09:23:10Z","publication":"Alzheimer's Research & Therapy","article_number":"136","article_type":"original","oa":1,"keyword":["Cognitive Neuroscience","Neurology (clinical)","Neurology"],"year":"2022","tmp":{"name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","image":"/images/cc_by.png","short":"CC BY (4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode"},"file":[{"file_id":"12413","date_created":"2023-01-27T07:53:18Z","access_level":"open_access","content_type":"application/pdf","checksum":"88e49715ad6a1abf0fdb27efd65368dc","success":1,"date_updated":"2023-01-27T07:53:18Z","file_name":"2022_AlzheimersResearch_MartinBelmont.pdf","file_size":11013325,"relation":"main_file","creator":"dernst"}],"article_processing_charge":"No","volume":14,"has_accepted_license":"1","month":"09","ddc":["570"],"file_date_updated":"2023-01-27T07:53:18Z","citation":{"ista":"Martín-Belmonte A, Aguado C, Alfaro-Ruiz R, Moreno-Martínez AE, de la Ossa L, Aso E, Gómez-Acero L, Shigemoto R, Fukazawa Y, Ciruela F, Luján R. 2022. Nanoscale alterations in GABAB receptors and GIRK channel organization on the hippocampus of APP/PS1 mice. Alzheimer’s Research &#38; Therapy. 14, 136.","short":"A. Martín-Belmonte, C. Aguado, R. Alfaro-Ruiz, A.E. Moreno-Martínez, L. de la Ossa, E. Aso, L. Gómez-Acero, R. Shigemoto, Y. Fukazawa, F. Ciruela, R. Luján, Alzheimer’s Research &#38; Therapy 14 (2022).","ama":"Martín-Belmonte A, Aguado C, Alfaro-Ruiz R, et al. Nanoscale alterations in GABAB receptors and GIRK channel organization on the hippocampus of APP/PS1 mice. <i>Alzheimer’s Research &#38; Therapy</i>. 2022;14. doi:<a href=\"https://doi.org/10.1186/s13195-022-01078-5\">10.1186/s13195-022-01078-5</a>","ieee":"A. Martín-Belmonte <i>et al.</i>, “Nanoscale alterations in GABAB receptors and GIRK channel organization on the hippocampus of APP/PS1 mice,” <i>Alzheimer’s Research &#38; Therapy</i>, vol. 14. Springer Nature, 2022.","apa":"Martín-Belmonte, A., Aguado, C., Alfaro-Ruiz, R., Moreno-Martínez, A. E., de la Ossa, L., Aso, E., … Luján, R. (2022). Nanoscale alterations in GABAB receptors and GIRK channel organization on the hippocampus of APP/PS1 mice. <i>Alzheimer’s Research &#38; Therapy</i>. Springer Nature. <a href=\"https://doi.org/10.1186/s13195-022-01078-5\">https://doi.org/10.1186/s13195-022-01078-5</a>","mla":"Martín-Belmonte, Alejandro, et al. “Nanoscale Alterations in GABAB Receptors and GIRK Channel Organization on the Hippocampus of APP/PS1 Mice.” <i>Alzheimer’s Research &#38; Therapy</i>, vol. 14, 136, Springer Nature, 2022, doi:<a href=\"https://doi.org/10.1186/s13195-022-01078-5\">10.1186/s13195-022-01078-5</a>.","chicago":"Martín-Belmonte, Alejandro, Carolina Aguado, Rocío Alfaro-Ruiz, Ana Esther Moreno-Martínez, Luis de la Ossa, Ester Aso, Laura Gómez-Acero, et al. “Nanoscale Alterations in GABAB Receptors and GIRK Channel Organization on the Hippocampus of APP/PS1 Mice.” <i>Alzheimer’s Research &#38; Therapy</i>. Springer Nature, 2022. <a href=\"https://doi.org/10.1186/s13195-022-01078-5\">https://doi.org/10.1186/s13195-022-01078-5</a>."},"day":"21","oa_version":"Published Version","publication_identifier":{"issn":["1758-9193"]},"status":"public","acknowledgement":"We thank Ms. Diane Latawiec for the English revision of the manuscript. Funding sources were the Spanish Ministerio de Economía y Competitividad, Junta de Comunidades de Castilla-La Mancha (Spain), and Life Science Innovation Center at University of Fukui. We thank Centres de Recerca de Catalunya (CERCA) Programme/Generalitat de Catalunya for IDIBELL institutional support. We thank Hitoshi Takagi and Takako Maegawa at the University of Fukui for their technical assistance on SDS-FRL experiments.\r\nThis work was supported by grants from the Spanish Ministerio de Economía y Competitividad (BFU2015-63769-R, RTI2018-095812-B-I00, and PID2021-125875OB-I00) and Junta de Comunidades de Castilla-La Mancha (SBPLY/17/180501/000229 and SBPLY/21/180501/000064) to RL, Life Science Innovation Center at University of Fukui and JSPS KAKENHI (Grant Numbers 16H04662, 19H03323, and 20H05058) to YF, and Margarita Salas fellowship from Ministerio de Universidades and Universidad de Castilla-La Mancha to AMB.","publication_status":"published","_id":"12212","title":"Nanoscale alterations in GABAB receptors and GIRK channel organization on the hippocampus of APP/PS1 mice","author":[{"last_name":"Martín-Belmonte","full_name":"Martín-Belmonte, Alejandro","first_name":"Alejandro"},{"first_name":"Carolina","last_name":"Aguado","full_name":"Aguado, Carolina"},{"first_name":"Rocío","full_name":"Alfaro-Ruiz, Rocío","last_name":"Alfaro-Ruiz"},{"first_name":"Ana Esther","last_name":"Moreno-Martínez","full_name":"Moreno-Martínez, Ana Esther"},{"first_name":"Luis","full_name":"de la Ossa, Luis","last_name":"de la Ossa"},{"first_name":"Ester","full_name":"Aso, Ester","last_name":"Aso"},{"last_name":"Gómez-Acero","full_name":"Gómez-Acero, Laura","first_name":"Laura"},{"orcid":"0000-0001-8761-9444","first_name":"Ryuichi","id":"499F3ABC-F248-11E8-B48F-1D18A9856A87","last_name":"Shigemoto","full_name":"Shigemoto, Ryuichi"},{"first_name":"Yugo","last_name":"Fukazawa","full_name":"Fukazawa, Yugo"},{"last_name":"Ciruela","full_name":"Ciruela, Francisco","first_name":"Francisco"},{"full_name":"Luján, Rafael","last_name":"Luján","first_name":"Rafael"}],"doi":"10.1186/s13195-022-01078-5","abstract":[{"lang":"eng","text":"Alzheimer’s disease (AD) is characterized by a reorganization of brain activity determining network hyperexcitability and loss of synaptic plasticity. Precisely, a dysfunction in metabotropic GABAB receptor signalling through G protein-gated inwardly rectifying K+ (GIRK or Kir3) channels on the hippocampus has been postulated. Thus, we determined the impact of amyloid-β (Aβ) pathology in GIRK channel density, subcellular distribution, and its association with GABAB receptors in hippocampal CA1 pyramidal neurons from the APP/PS1 mouse model using quantitative SDS-digested freeze-fracture replica labelling (SDS-FRL) and proximity ligation in situ assay (P-LISA). In wild type mice, single SDS-FRL detection revealed a similar dendritic gradient for GIRK1 and GIRK2 in CA1 pyramidal cells, with higher densities in spines, and GIRK3 showed a lower and uniform distribution. Double SDS-FRL showed a co-clustering of GIRK2 and GIRK1 in post- and presynaptic compartments, but not for GIRK2 and GIRK3. Likewise, double GABAB1 and GIRK2 SDS-FRL detection displayed a high degree of co-clustering in nanodomains (40–50 nm) mostly in spines and axon terminals. In APP/PS1 mice, the density of GIRK2 and GIRK1, but not for GIRK3, was significantly reduced along the neuronal surface of CA1 pyramidal cells and in axon terminals contacting them. Importantly, GABAB1 and GIRK2 co-clustering was not present in APP/PS1 mice. Similarly, P-LISA experiments revealed a significant reduction in GABAB1 and GIRK2 interaction on the hippocampus of this animal model. Overall, our results provide compelling evidence showing a significant reduction on the cell surface density of pre- and postsynaptic GIRK1 and GIRK2, but not GIRK3, and a decline in GABAB receptors and GIRK2 channels co-clustering in hippocampal pyramidal neurons from APP/PS1 mice, thus suggesting that a disruption in the GABAB receptor–GIRK channel membrane assembly causes dysregulation in the GABAB signalling via GIRK channels in this AD animal model."}]},{"file":[{"file_name":"2022_NPJ_Paerschke.pdf","relation":"main_file","creator":"dernst","file_size":1852598,"success":1,"date_updated":"2023-01-27T07:59:27Z","access_level":"open_access","checksum":"d93b477b5b95c0d1b8f9fef90a81f565","content_type":"application/pdf","file_id":"12414","date_created":"2023-01-27T07:59:27Z"}],"tmp":{"name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","image":"/images/cc_by.png","short":"CC BY (4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode"},"volume":7,"article_processing_charge":"No","has_accepted_license":"1","month":"09","file_date_updated":"2023-01-27T07:59:27Z","ddc":["530"],"day":"10","citation":{"ista":"Paerschke E, Chen W-C, Ray R, Chen C-C. 2022. Evolution of electronic and magnetic properties of Sr₂IrO₄ under strain. npj Quantum Materials. 7, 90.","short":"E. Paerschke, W.-C. Chen, R. Ray, C.-C. Chen, Npj Quantum Materials 7 (2022).","ama":"Paerschke E, Chen W-C, Ray R, Chen C-C. Evolution of electronic and magnetic properties of Sr₂IrO₄ under strain. <i>npj Quantum Materials</i>. 2022;7. doi:<a href=\"https://doi.org/10.1038/s41535-022-00496-w\">10.1038/s41535-022-00496-w</a>","apa":"Paerschke, E., Chen, W.-C., Ray, R., &#38; Chen, C.-C. (2022). Evolution of electronic and magnetic properties of Sr₂IrO₄ under strain. <i>Npj Quantum Materials</i>. Springer Nature. <a href=\"https://doi.org/10.1038/s41535-022-00496-w\">https://doi.org/10.1038/s41535-022-00496-w</a>","ieee":"E. Paerschke, W.-C. Chen, R. Ray, and C.-C. Chen, “Evolution of electronic and magnetic properties of Sr₂IrO₄ under strain,” <i>npj Quantum Materials</i>, vol. 7. Springer Nature, 2022.","mla":"Paerschke, Ekaterina, et al. “Evolution of Electronic and Magnetic Properties of Sr₂IrO₄ under Strain.” <i>Npj Quantum Materials</i>, vol. 7, 90, Springer Nature, 2022, doi:<a href=\"https://doi.org/10.1038/s41535-022-00496-w\">10.1038/s41535-022-00496-w</a>.","chicago":"Paerschke, Ekaterina, Wei-Chih Chen, Rajyavardhan Ray, and Cheng-Chien Chen. “Evolution of Electronic and Magnetic Properties of Sr₂IrO₄ under Strain.” <i>Npj Quantum Materials</i>. Springer Nature, 2022. <a href=\"https://doi.org/10.1038/s41535-022-00496-w\">https://doi.org/10.1038/s41535-022-00496-w</a>."},"oa_version":"Published Version","project":[{"call_identifier":"H2020","name":"ISTplus - Postdoctoral Fellowships","grant_number":"754411","_id":"260C2330-B435-11E9-9278-68D0E5697425"}],"publication_identifier":{"eissn":["2397-4648"]},"ec_funded":1,"publication_status":"published","acknowledgement":"E.M.P. thanks Eugenio Paris, Thorsten Schmitt, Krzysztof Wohlfeld, and other coauthors for an inspiring previous collaboration23, and is grateful to Gang Cao, Ambrose Seo, and Jungho Kim for insightful discussions. R.R. acknowledges helpful discussion with Sanjeev Kumar and Manuel Richter. This project has received funding from the European Union’s Horizon 2020 research and innovation program under the Marie Sklodowska-Curie grant agreement No 754411. C.C.C. acknowledges support from the U.S. National Science Foundation Award No. DMR-2142801.","status":"public","_id":"12213","author":[{"last_name":"Paerschke","full_name":"Paerschke, Ekaterina","first_name":"Ekaterina","id":"8275014E-6063-11E9-9B7F-6338E6697425","orcid":"0000-0003-0853-8182"},{"first_name":"Wei-Chih","last_name":"Chen","full_name":"Chen, Wei-Chih"},{"first_name":"Rajyavardhan","last_name":"Ray","full_name":"Ray, Rajyavardhan"},{"last_name":"Chen","full_name":"Chen, Cheng-Chien","first_name":"Cheng-Chien"}],"title":"Evolution of electronic and magnetic properties of Sr₂IrO₄ under strain","doi":"10.1038/s41535-022-00496-w","abstract":[{"lang":"eng","text":"Motivated by properties-controlling potential of the strain, we investigate strain dependence of structure, electronic, and magnetic properties of Sr2IrO4 using complementary theoretical tools: ab-initio calculations, analytical approaches (rigid octahedra picture, Slater-Koster integrals), and extended t−J model. We find that strain affects both Ir-Ir distance and Ir-O-Ir angle, and the rigid octahedra picture is not relevant. Second, we find fundamentally different behavior for compressive and tensile strain. One remarkable feature is the formation of two subsets of bond- and orbital-dependent carriers, a compass-like model, under compression. This originates from the strain-induced renormalization of the Ir-O-Ir superexchange and O on-site energy. We also show that under compressive (tensile) strain, Fermi surface becomes highly dispersive (relatively flat). Already at a tensile strain of 1.5%, we observe spectral weight redistribution, with the low-energy band acquiring almost purely singlet character. These results can be directly compared with future experiments."}],"intvolume":"         7","publisher":"Springer Nature","quality_controlled":"1","type":"journal_article","language":[{"iso":"eng"}],"isi":1,"user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","department":[{"_id":"MiLe"}],"scopus_import":"1","date_created":"2023-01-16T09:46:01Z","external_id":{"isi":["000852381200003"]},"date_published":"2022-09-10T00:00:00Z","date_updated":"2023-08-04T09:23:43Z","publication":"npj Quantum Materials","article_type":"original","article_number":"90","related_material":{"link":[{"url":"https://doi.org/10.1038/s41535-022-00510-1","relation":"erratum"}]},"oa":1,"keyword":["Condensed Matter Physics","Electronic","Optical and Magnetic Materials"],"year":"2022"},{"page":"3865-3894","article_type":"original","date_updated":"2023-08-04T09:24:17Z","publication":"Journal of the London Mathematical Society","keyword":["General Mathematics"],"year":"2022","oa":1,"type":"journal_article","quality_controlled":"1","language":[{"iso":"eng"}],"isi":1,"publisher":"Wiley","main_file_link":[{"open_access":"1","url":"https://doi.org/10.48550/arXiv.2102.02037"}],"intvolume":"       106","date_created":"2023-01-16T09:46:13Z","scopus_import":"1","date_published":"2022-09-18T00:00:00Z","external_id":{"isi":["000854878500001"],"arxiv":["2102.02037"]},"user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","department":[{"_id":"LaEr"}],"ec_funded":1,"publication_status":"published","acknowledgement":"Geher was supported by the Leverhulme Trust Early Career Fellowship (ECF-2018-125), and also by the Hungarian National Research, Development and Innovation Office - NKFIH (grant no. K115383 and K134944).\r\nTitkos was supported by the Hungarian National Research, Development and Innovation Office - NKFIH (grant no. PD128374, grant no. K115383 and K134944), by the J´anos Bolyai Research Scholarship of the Hungarian Academy of Sciences, and by the UNKP-20-5-BGE-1 New National Excellence Program of the ´Ministry of Innovation and Technology.\r\nVirosztek was supported by the European Union’s Horizon 2020 research and innovation program under the Marie Sklodowska-Curie Grant Agreement No. 846294, by the Momentum program of the Hungarian Academy of Sciences under grant agreement no. LP2021-15/2021, and partially supported by the Hungarian National Research, Development and Innovation Office - NKFIH (grants no. K124152 and no. KH129601). ","status":"public","project":[{"_id":"26A455A6-B435-11E9-9278-68D0E5697425","grant_number":"846294","name":"Geometric study of Wasserstein spaces and free probability","call_identifier":"H2020"}],"publication_identifier":{"issn":["0024-6107"],"eissn":["1469-7750"]},"doi":"10.1112/jlms.12676","abstract":[{"lang":"eng","text":"Motivated by Kloeckner’s result on the isometry group of the quadratic Wasserstein space W2(Rn), we describe the isometry group Isom(Wp(E)) for all parameters 0 < p < ∞ and for all separable real Hilbert spaces E. In particular, we show that Wp(X) is isometrically rigid for all Polish space X whenever 0 < p < 1. This is a consequence of our more general result: we prove that W1(X) is isometrically rigid if X is a complete separable metric space that satisfies the strict triangle inequality. Furthermore, we show that this latter rigidity result does not generalise to parameters p > 1, by solving Kloeckner’s problem affirmatively on the existence of mass-splitting isometries. "}],"issue":"4","_id":"12214","title":"The isometry group of Wasserstein spaces: The Hilbertian case","author":[{"last_name":"Gehér","full_name":"Gehér, György Pál","first_name":"György Pál"},{"first_name":"Tamás","full_name":"Titkos, Tamás","last_name":"Titkos"},{"orcid":"0000-0003-1109-5511","full_name":"Virosztek, Daniel","last_name":"Virosztek","id":"48DB45DA-F248-11E8-B48F-1D18A9856A87","first_name":"Daniel"}],"article_processing_charge":"No","volume":106,"arxiv":1,"oa_version":"Preprint","month":"09","citation":{"ama":"Gehér GP, Titkos T, Virosztek D. The isometry group of Wasserstein spaces: The Hilbertian case. <i>Journal of the London Mathematical Society</i>. 2022;106(4):3865-3894. doi:<a href=\"https://doi.org/10.1112/jlms.12676\">10.1112/jlms.12676</a>","ista":"Gehér GP, Titkos T, Virosztek D. 2022. The isometry group of Wasserstein spaces: The Hilbertian case. Journal of the London Mathematical Society. 106(4), 3865–3894.","short":"G.P. Gehér, T. Titkos, D. Virosztek, Journal of the London Mathematical Society 106 (2022) 3865–3894.","apa":"Gehér, G. P., Titkos, T., &#38; Virosztek, D. (2022). The isometry group of Wasserstein spaces: The Hilbertian case. <i>Journal of the London Mathematical Society</i>. Wiley. <a href=\"https://doi.org/10.1112/jlms.12676\">https://doi.org/10.1112/jlms.12676</a>","ieee":"G. P. Gehér, T. Titkos, and D. Virosztek, “The isometry group of Wasserstein spaces: The Hilbertian case,” <i>Journal of the London Mathematical Society</i>, vol. 106, no. 4. Wiley, pp. 3865–3894, 2022.","mla":"Gehér, György Pál, et al. “The Isometry Group of Wasserstein Spaces: The Hilbertian Case.” <i>Journal of the London Mathematical Society</i>, vol. 106, no. 4, Wiley, 2022, pp. 3865–94, doi:<a href=\"https://doi.org/10.1112/jlms.12676\">10.1112/jlms.12676</a>.","chicago":"Gehér, György Pál, Tamás Titkos, and Daniel Virosztek. “The Isometry Group of Wasserstein Spaces: The Hilbertian Case.” <i>Journal of the London Mathematical Society</i>. Wiley, 2022. <a href=\"https://doi.org/10.1112/jlms.12676\">https://doi.org/10.1112/jlms.12676</a>."},"day":"18"},{"oa":1,"keyword":["Discrete Mathematics and Combinatorics","Geometry and Topology","Numerical Analysis","Algebra and Number Theory"],"year":"2022","date_updated":"2023-08-04T09:24:51Z","publication":"Linear Algebra and its Applications","article_type":"original","page":"289-310","user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","department":[{"_id":"JaMa"}],"scopus_import":"1","date_created":"2023-01-16T09:46:38Z","date_published":"2022-12-01T00:00:00Z","external_id":{"isi":["000860689600014"]},"intvolume":"       654","publisher":"Elsevier","language":[{"iso":"eng"}],"type":"journal_article","quality_controlled":"1","isi":1,"_id":"12216","author":[{"last_name":"Carlen","full_name":"Carlen, Eric A.","first_name":"Eric A."},{"id":"D8F41E38-9E66-11E9-A9E2-65C2E5697425","first_name":"Haonan","full_name":"Zhang, Haonan","last_name":"Zhang"}],"title":"Monotonicity versions of Epstein's concavity theorem and related inequalities","doi":"10.1016/j.laa.2022.09.001","abstract":[{"lang":"eng","text":"Many trace inequalities can be expressed either as concavity/convexity theorems or as monotonicity theorems. A classic example is the joint convexity of the quantum relative entropy which is equivalent to the Data Processing Inequality. The latter says that quantum operations can never increase the relative entropy. The monotonicity versions often have many advantages, and often have direct physical application, as in the example just mentioned. Moreover, the monotonicity results are often valid for a larger class of maps than, say, quantum operations (which are completely positive). In this paper we prove several new monotonicity results, the first of which is a monotonicity theorem that has as a simple corollary a celebrated concavity theorem of Epstein. Our starting points are the monotonicity versions of the Lieb Concavity and the Lieb Convexity Theorems. We also give two new proofs of these in their general forms using interpolation. We then prove our new monotonicity theorems by several duality arguments."}],"project":[{"name":"Curvature-dimension in noncommutative analysis","_id":"eb958bca-77a9-11ec-83b8-c565cb50d8d6","grant_number":"M03337"}],"publication_identifier":{"issn":["0024-3795"]},"status":"public","publication_status":"published","acknowledgement":"Work partially supported by the Lise Meitner fellowship, Austrian Science Fund (FWF) M3337.","ddc":["510"],"month":"12","file_date_updated":"2023-01-27T08:08:39Z","day":"01","citation":{"ieee":"E. A. Carlen and H. Zhang, “Monotonicity versions of Epstein’s concavity theorem and related inequalities,” <i>Linear Algebra and its Applications</i>, vol. 654. Elsevier, pp. 289–310, 2022.","apa":"Carlen, E. A., &#38; Zhang, H. (2022). Monotonicity versions of Epstein’s concavity theorem and related inequalities. <i>Linear Algebra and Its Applications</i>. Elsevier. <a href=\"https://doi.org/10.1016/j.laa.2022.09.001\">https://doi.org/10.1016/j.laa.2022.09.001</a>","ama":"Carlen EA, Zhang H. Monotonicity versions of Epstein’s concavity theorem and related inequalities. <i>Linear Algebra and its Applications</i>. 2022;654:289-310. doi:<a href=\"https://doi.org/10.1016/j.laa.2022.09.001\">10.1016/j.laa.2022.09.001</a>","short":"E.A. Carlen, H. Zhang, Linear Algebra and Its Applications 654 (2022) 289–310.","ista":"Carlen EA, Zhang H. 2022. Monotonicity versions of Epstein’s concavity theorem and related inequalities. Linear Algebra and its Applications. 654, 289–310.","mla":"Carlen, Eric A., and Haonan Zhang. “Monotonicity Versions of Epstein’s Concavity Theorem and Related Inequalities.” <i>Linear Algebra and Its Applications</i>, vol. 654, Elsevier, 2022, pp. 289–310, doi:<a href=\"https://doi.org/10.1016/j.laa.2022.09.001\">10.1016/j.laa.2022.09.001</a>.","chicago":"Carlen, Eric A., and Haonan Zhang. “Monotonicity Versions of Epstein’s Concavity Theorem and Related Inequalities.” <i>Linear Algebra and Its Applications</i>. Elsevier, 2022. <a href=\"https://doi.org/10.1016/j.laa.2022.09.001\">https://doi.org/10.1016/j.laa.2022.09.001</a>."},"oa_version":"Published Version","file":[{"success":1,"date_updated":"2023-01-27T08:08:39Z","access_level":"open_access","checksum":"cf3cb7e7e34baa967849f01d8f0c1ae4","content_type":"application/pdf","file_name":"2022_LinearAlgebra_Carlen.pdf","file_size":441184,"creator":"dernst","relation":"main_file","file_id":"12415","date_created":"2023-01-27T08:08:39Z"}],"tmp":{"name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","image":"/images/cc_by.png","short":"CC BY (4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode"},"volume":654,"article_processing_charge":"Yes (via OA deal)","has_accepted_license":"1"},{"article_processing_charge":"No","volume":13,"has_accepted_license":"1","file":[{"file_name":"2022_NatureCommunications_Randriamanantsoa.pdf","file_size":22645149,"relation":"main_file","creator":"dernst","success":1,"date_updated":"2023-01-27T08:14:48Z","access_level":"open_access","checksum":"295261b5172274fd5b8f85a6a6058828","content_type":"application/pdf","file_id":"12416","date_created":"2023-01-27T08:14:48Z"}],"tmp":{"name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","image":"/images/cc_by.png","short":"CC BY (4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode"},"oa_version":"Published Version","ddc":["570"],"month":"09","file_date_updated":"2023-01-27T08:14:48Z","day":"05","citation":{"ama":"Randriamanantsoa S, Papargyriou A, Maurer HC, et al. Spatiotemporal dynamics of self-organized branching in pancreas-derived organoids. <i>Nature Communications</i>. 2022;13. doi:<a href=\"https://doi.org/10.1038/s41467-022-32806-y\">10.1038/s41467-022-32806-y</a>","ista":"Randriamanantsoa S, Papargyriou A, Maurer HC, Peschke K, Schuster M, Zecchin G, Steiger K, Öllinger R, Saur D, Scheel C, Rad R, Hannezo EB, Reichert M, Bausch AR. 2022. Spatiotemporal dynamics of self-organized branching in pancreas-derived organoids. Nature Communications. 13, 5219.","short":"S. Randriamanantsoa, A. Papargyriou, H.C. Maurer, K. Peschke, M. Schuster, G. Zecchin, K. Steiger, R. Öllinger, D. Saur, C. Scheel, R. Rad, E.B. Hannezo, M. Reichert, A.R. Bausch, Nature Communications 13 (2022).","ieee":"S. Randriamanantsoa <i>et al.</i>, “Spatiotemporal dynamics of self-organized branching in pancreas-derived organoids,” <i>Nature Communications</i>, vol. 13. Springer Nature, 2022.","apa":"Randriamanantsoa, S., Papargyriou, A., Maurer, H. C., Peschke, K., Schuster, M., Zecchin, G., … Bausch, A. R. (2022). Spatiotemporal dynamics of self-organized branching in pancreas-derived organoids. <i>Nature Communications</i>. Springer Nature. <a href=\"https://doi.org/10.1038/s41467-022-32806-y\">https://doi.org/10.1038/s41467-022-32806-y</a>","mla":"Randriamanantsoa, S., et al. “Spatiotemporal Dynamics of Self-Organized Branching in Pancreas-Derived Organoids.” <i>Nature Communications</i>, vol. 13, 5219, Springer Nature, 2022, doi:<a href=\"https://doi.org/10.1038/s41467-022-32806-y\">10.1038/s41467-022-32806-y</a>.","chicago":"Randriamanantsoa, S., A. Papargyriou, H. C. Maurer, K. Peschke, M. Schuster, G. Zecchin, K. Steiger, et al. “Spatiotemporal Dynamics of Self-Organized Branching in Pancreas-Derived Organoids.” <i>Nature Communications</i>. Springer Nature, 2022. <a href=\"https://doi.org/10.1038/s41467-022-32806-y\">https://doi.org/10.1038/s41467-022-32806-y</a>."},"ec_funded":1,"publication_status":"published","status":"public","acknowledgement":"A.R.B. acknowledges the financial support of the European Research Council (ERC) through the funding of the grant Principles of Integrin Mechanics and Adhesion (PoINT) and the German Research Foundation (DFG, SFB 1032, project ID 201269156). E.H. was supported by the European Union (European Research Council Starting Grant 851288). D.S., M.R., and R.R. acknowledge the support by the German Research Foundation (DFG, SFB1321 Modeling and Targeting Pancreatic Cancer, Project S01, project ID 329628492). C.S. and M.R. acknowledge the support by the German Research Foundation (DFG, SFB1321 Modeling and Targeting Pancreatic Cancer, Project 12, project ID 329628492). M.R. was supported by the German Research Foundation (DFG RE 3723/4-1). A.P. and M.R. were supported by the German Cancer Aid (Max-Eder Program 111273 and 70114328).\r\nOpen Access funding enabled and organized by Projekt DEAL.","project":[{"_id":"05943252-7A3F-11EA-A408-12923DDC885E","grant_number":"851288","name":"Design Principles of Branching Morphogenesis","call_identifier":"H2020"}],"publication_identifier":{"issn":["2041-1723"]},"doi":"10.1038/s41467-022-32806-y","abstract":[{"lang":"eng","text":"The development dynamics and self-organization of glandular branched epithelia is of utmost importance for our understanding of diverse processes ranging from normal tissue growth to the growth of cancerous tissues. Using single primary murine pancreatic ductal adenocarcinoma (PDAC) cells embedded in a collagen matrix and adapted media supplementation, we generate organoids that self-organize into highly branched structures displaying a seamless lumen connecting terminal end buds, replicating in vivo PDAC architecture. We identify distinct morphogenesis phases, each characterized by a unique pattern of cell invasion, matrix deformation, protein expression, and respective molecular dependencies. We propose a minimal theoretical model of a branching and proliferating tissue, capturing the dynamics of the first phases. Observing the interaction of morphogenesis, mechanical environment and gene expression in vitro sets a benchmark for the understanding of self-organization processes governing complex organoid structure formation processes and branching morphogenesis."}],"_id":"12217","author":[{"first_name":"S.","last_name":"Randriamanantsoa","full_name":"Randriamanantsoa, S."},{"last_name":"Papargyriou","full_name":"Papargyriou, A.","first_name":"A."},{"full_name":"Maurer, H. C.","last_name":"Maurer","first_name":"H. C."},{"full_name":"Peschke, K.","last_name":"Peschke","first_name":"K."},{"full_name":"Schuster, M.","last_name":"Schuster","first_name":"M."},{"full_name":"Zecchin, G.","last_name":"Zecchin","first_name":"G."},{"last_name":"Steiger","full_name":"Steiger, K.","first_name":"K."},{"full_name":"Öllinger, R.","last_name":"Öllinger","first_name":"R."},{"first_name":"D.","last_name":"Saur","full_name":"Saur, D."},{"first_name":"C.","full_name":"Scheel, C.","last_name":"Scheel"},{"first_name":"R.","full_name":"Rad, R.","last_name":"Rad"},{"orcid":"0000-0001-6005-1561","first_name":"Edouard B","id":"3A9DB764-F248-11E8-B48F-1D18A9856A87","last_name":"Hannezo","full_name":"Hannezo, Edouard B"},{"full_name":"Reichert, M.","last_name":"Reichert","first_name":"M."},{"first_name":"A. R.","last_name":"Bausch","full_name":"Bausch, A. R."}],"title":"Spatiotemporal dynamics of self-organized branching in pancreas-derived organoids","type":"journal_article","language":[{"iso":"eng"}],"quality_controlled":"1","isi":1,"intvolume":"        13","publisher":"Springer Nature","scopus_import":"1","date_created":"2023-01-16T09:46:53Z","date_published":"2022-09-05T00:00:00Z","external_id":{"isi":["000850348400025"]},"user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","department":[{"_id":"EdHa"}],"article_type":"original","article_number":"5219","related_material":{"record":[{"relation":"research_data","status":"public","id":"13068"}]},"date_updated":"2023-08-04T09:25:23Z","publication":"Nature Communications","keyword":["General Physics and Astronomy","General Biochemistry","Genetics and Molecular Biology","General Chemistry","Multidisciplinary"],"year":"2022","oa":1},{"volume":5,"article_processing_charge":"No","has_accepted_license":"1","file":[{"file_id":"12417","date_created":"2023-01-27T08:23:46Z","file_name":"2022_CommBiology_Muhia.pdf","relation":"main_file","file_size":3968356,"creator":"dernst","access_level":"open_access","checksum":"bd95be1e77090208b79bc45ea8785d0b","content_type":"application/pdf","success":1,"date_updated":"2023-01-27T08:23:46Z"}],"tmp":{"name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","image":"/images/cc_by.png","short":"CC BY (4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode"},"oa_version":"Published Version","file_date_updated":"2023-01-27T08:23:46Z","month":"06","ddc":["570"],"citation":{"mla":"Muhia, Mary W., et al. “Muskelin Regulates Actin-Dependent Synaptic Changes and Intrinsic Brain Activity Relevant to Behavioral and Cognitive Processes.” <i>Communications Biology</i>, vol. 5, 589, Springer Nature, 2022, doi:<a href=\"https://doi.org/10.1038/s42003-022-03446-1\">10.1038/s42003-022-03446-1</a>.","chicago":"Muhia, Mary W, PingAn YuanXiang, Jan Sedlacik, Jürgen R. Schwarz, Frank F. Heisler, Kira V. Gromova, Edda Thies, et al. “Muskelin Regulates Actin-Dependent Synaptic Changes and Intrinsic Brain Activity Relevant to Behavioral and Cognitive Processes.” <i>Communications Biology</i>. Springer Nature, 2022. <a href=\"https://doi.org/10.1038/s42003-022-03446-1\">https://doi.org/10.1038/s42003-022-03446-1</a>.","ieee":"M. W. Muhia <i>et al.</i>, “Muskelin regulates actin-dependent synaptic changes and intrinsic brain activity relevant to behavioral and cognitive processes,” <i>Communications Biology</i>, vol. 5. Springer Nature, 2022.","apa":"Muhia, M. W., YuanXiang, P., Sedlacik, J., Schwarz, J. R., Heisler, F. F., Gromova, K. V., … Kneussel, M. (2022). Muskelin regulates actin-dependent synaptic changes and intrinsic brain activity relevant to behavioral and cognitive processes. <i>Communications Biology</i>. Springer Nature. <a href=\"https://doi.org/10.1038/s42003-022-03446-1\">https://doi.org/10.1038/s42003-022-03446-1</a>","ama":"Muhia MW, YuanXiang P, Sedlacik J, et al. Muskelin regulates actin-dependent synaptic changes and intrinsic brain activity relevant to behavioral and cognitive processes. <i>Communications Biology</i>. 2022;5. doi:<a href=\"https://doi.org/10.1038/s42003-022-03446-1\">10.1038/s42003-022-03446-1</a>","ista":"Muhia MW, YuanXiang P, Sedlacik J, Schwarz JR, Heisler FF, Gromova KV, Thies E, Breiden P, Pechmann Y, Kreutz MR, Kneussel M. 2022. Muskelin regulates actin-dependent synaptic changes and intrinsic brain activity relevant to behavioral and cognitive processes. Communications Biology. 5, 589.","short":"M.W. Muhia, P. YuanXiang, J. Sedlacik, J.R. Schwarz, F.F. Heisler, K.V. Gromova, E. Thies, P. Breiden, Y. Pechmann, M.R. Kreutz, M. Kneussel, Communications Biology 5 (2022)."},"day":"15","status":"public","publication_status":"published","acknowledgement":"The authors are grateful to the UKE Animal Facilities (Hamburg) for animal husbandry and Dr. Bastian Tiemann for his veterinary expertise and supervision of animal care. We thank Dr. Franco Lombino for critically reading the manuscript and for helpful discussion. This work was supported by grants from the Deutsche Forschungsgemeinschaft (DFG) (FOR2419-KN556/11-1, FOR2419-KN556/11-2, KN556/12-1) and the Landesforschungsförderung Hamburg (LFF-FV76) to M.K.\r\nOpen Access funding enabled and organized by Projekt DEAL.","publication_identifier":{"issn":["2399-3642"]},"doi":"10.1038/s42003-022-03446-1","abstract":[{"lang":"eng","text":"Muskelin (Mkln1) is implicated in neuronal function, regulating plasma membrane receptor trafficking. However, its influence on intrinsic brain activity and corresponding behavioral processes remains unclear. Here we show that murine <jats:italic>Mkln1</jats:italic> knockout causes non-habituating locomotor activity, increased exploratory drive, and decreased locomotor response to amphetamine. Muskelin deficiency impairs social novelty detection while promoting the retention of spatial reference memory and fear extinction recall. This is strongly mirrored in either weaker or stronger resting-state functional connectivity between critical circuits mediating locomotor exploration and cognition. We show that <jats:italic>Mkln1</jats:italic> deletion alters dendrite branching and spine structure, coinciding with enhanced AMPAR-mediated synaptic transmission but selective impairment in synaptic potentiation maintenance. We identify muskelin at excitatory synapses and highlight its role in regulating dendritic spine actin stability. Our findings point to aberrant spine actin modulation and changes in glutamatergic synaptic function as critical mechanisms that contribute to the neurobehavioral phenotype arising from <jats:italic>Mkln1</jats:italic> ablation."}],"_id":"12224","title":"Muskelin regulates actin-dependent synaptic changes and intrinsic brain activity relevant to behavioral and cognitive processes","author":[{"last_name":"Muhia","full_name":"Muhia, Mary W","first_name":"Mary W","id":"ab7ed20f-09f7-11eb-909c-d5d0b443ee9d"},{"last_name":"YuanXiang","full_name":"YuanXiang, PingAn","first_name":"PingAn"},{"last_name":"Sedlacik","full_name":"Sedlacik, Jan","first_name":"Jan"},{"last_name":"Schwarz","full_name":"Schwarz, Jürgen R.","first_name":"Jürgen R."},{"first_name":"Frank F.","last_name":"Heisler","full_name":"Heisler, Frank F."},{"first_name":"Kira V.","full_name":"Gromova, Kira V.","last_name":"Gromova"},{"first_name":"Edda","last_name":"Thies","full_name":"Thies, Edda"},{"first_name":"Petra","full_name":"Breiden, Petra","last_name":"Breiden"},{"last_name":"Pechmann","full_name":"Pechmann, Yvonne","first_name":"Yvonne"},{"first_name":"Michael R.","full_name":"Kreutz, Michael R.","last_name":"Kreutz"},{"full_name":"Kneussel, Matthias","last_name":"Kneussel","first_name":"Matthias"}],"quality_controlled":"1","language":[{"iso":"eng"}],"type":"journal_article","isi":1,"publisher":"Springer Nature","intvolume":"         5","date_created":"2023-01-16T09:48:19Z","scopus_import":"1","external_id":{"isi":["000811777900003"]},"date_published":"2022-06-15T00:00:00Z","user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","department":[{"_id":"PreCl"}],"article_number":"589","article_type":"original","date_updated":"2023-08-04T09:25:59Z","publication":"Communications Biology","keyword":["General Agricultural and Biological Sciences","General Biochemistry","Genetics and Molecular Biology","Medicine (miscellaneous)"],"year":"2022","oa":1},{"tmp":{"name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","image":"/images/cc_by.png","short":"CC BY (4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode"},"file":[{"date_created":"2023-01-27T08:56:18Z","file_id":"12418","checksum":"e024a75f14ce5667795a31e44a259c52","content_type":"application/pdf","access_level":"open_access","date_updated":"2023-01-27T08:56:18Z","success":1,"creator":"dernst","relation":"main_file","file_size":3625627,"file_name":"2022_ScientificReports_Currin.pdf"}],"has_accepted_license":"1","volume":12,"article_processing_charge":"No","day":"02","citation":{"ama":"Currin C, Vera SV, Khaledi-Nasab A. Depolarization of echo chambers by random dynamical nudge. <i>Scientific Reports</i>. 2022;12. doi:<a href=\"https://doi.org/10.1038/s41598-022-12494-w\">10.1038/s41598-022-12494-w</a>","short":"C. Currin, S.V. Vera, A. Khaledi-Nasab, Scientific Reports 12 (2022).","ista":"Currin C, Vera SV, Khaledi-Nasab A. 2022. Depolarization of echo chambers by random dynamical nudge. Scientific Reports. 12, 9234.","ieee":"C. Currin, S. V. Vera, and A. Khaledi-Nasab, “Depolarization of echo chambers by random dynamical nudge,” <i>Scientific Reports</i>, vol. 12. Springer Nature, 2022.","apa":"Currin, C., Vera, S. V., &#38; Khaledi-Nasab, A. (2022). Depolarization of echo chambers by random dynamical nudge. <i>Scientific Reports</i>. Springer Nature. <a href=\"https://doi.org/10.1038/s41598-022-12494-w\">https://doi.org/10.1038/s41598-022-12494-w</a>","chicago":"Currin, Christopher, Sebastián Vallejo Vera, and Ali Khaledi-Nasab. “Depolarization of Echo Chambers by Random Dynamical Nudge.” <i>Scientific Reports</i>. Springer Nature, 2022. <a href=\"https://doi.org/10.1038/s41598-022-12494-w\">https://doi.org/10.1038/s41598-022-12494-w</a>.","mla":"Currin, Christopher, et al. “Depolarization of Echo Chambers by Random Dynamical Nudge.” <i>Scientific Reports</i>, vol. 12, 9234, Springer Nature, 2022, doi:<a href=\"https://doi.org/10.1038/s41598-022-12494-w\">10.1038/s41598-022-12494-w</a>."},"file_date_updated":"2023-01-27T08:56:18Z","ddc":["570"],"pmid":1,"month":"06","oa_version":"Published Version","publication_identifier":{"issn":["2045-2322"]},"status":"public","publication_status":"published","acknowledgement":"CBC and AKN would like to thank Neuromatch Academy https://www.neuromatchacademy.org for introducing the authors to each other. We thank Dr. Krešimir Josic (University of Houston) , Fabian Baumann (Humboldt University) and Dr. Igor M. Sokolov (Humboldt University) for carefully reading the early versions of the manuscript and providing constructive feedback. CBC is supported by the German Deutscher Akademischer Austauschdienst (DAAD, https://daad.de), the South African National Research Foundation (NRF, https://nrf.ac.za), the University of Cape Town (UCT, https://uct.ac.za), and the NOMIS Foundation through the NOMIS Fellowships at IST Austria program (https://nomisfoundation.ch). SVV appreciate the generosity of Tecnológico de Monterrey for covering the publication fee.","author":[{"orcid":"0000-0002-4809-5059","full_name":"Currin, Christopher","last_name":"Currin","id":"e8321fc5-3091-11eb-8a53-83f309a11ac9","first_name":"Christopher"},{"first_name":"Sebastián Vallejo","full_name":"Vera, Sebastián Vallejo","last_name":"Vera"},{"first_name":"Ali","full_name":"Khaledi-Nasab, Ali","last_name":"Khaledi-Nasab"}],"title":"Depolarization of echo chambers by random dynamical nudge","_id":"12225","abstract":[{"text":"In social networks, users often engage with like-minded peers. This selective exposure to opinions might result in echo chambers, i.e., political fragmentation and social polarization of user interactions. When echo chambers form, opinions have a bimodal distribution with two peaks on opposite sides. In certain issues, where either extreme positions contain a degree of misinformation, neutral consensus is preferable for promoting discourse. In this paper, we use an opinion dynamics model that naturally forms echo chambers in order to find a feedback mechanism that bridges these communities and leads to a neutral consensus. We introduce the <jats:italic>random dynamical nudge</jats:italic> (RDN), which presents each agent with input from a random selection of other agents’ opinions and does not require surveillance of every person’s opinions. Our computational results in two different models suggest that the RDN leads to a unimodal distribution of opinions centered around the neutral consensus. Furthermore, the RDN is effective both for preventing the formation of echo chambers and also for depolarizing existing echo chambers. Due to the simple and robust nature of the RDN, social media networks might be able to implement a version of this self-feedback mechanism, when appropriate, to prevent the segregation of online communities on complex social issues.","lang":"eng"}],"doi":"10.1038/s41598-022-12494-w","intvolume":"        12","publisher":"Springer Nature","isi":1,"type":"journal_article","language":[{"iso":"eng"}],"quality_controlled":"1","department":[{"_id":"TiVo"}],"user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","external_id":{"isi":["000805561200024"],"pmid":["35654942"]},"date_published":"2022-06-02T00:00:00Z","scopus_import":"1","date_created":"2023-01-16T09:48:30Z","publication":"Scientific Reports","date_updated":"2023-08-04T09:26:30Z","article_type":"original","article_number":"9234","oa":1,"year":"2022","keyword":["Multidisciplinary"]}]