[{"related_material":{"record":[{"id":"15009","relation":"used_in_publication","status":"public"}]},"keyword":["sex chromosome evolution","genome assembly","dosage compensation"],"day":"02","doi":"10.15479/AT:ISTA:14705","year":"2024","oa":1,"publisher":"Institute of Science and Technology Austria","file_date_updated":"2023-12-22T14:14:06Z","date_published":"2024-01-02T00:00:00Z","title":"Data from \"Chromosome-level assembly of Artemia franciscana sheds light on sex-chromosome differentiation\"","abstract":[{"text":"Since the commercialization of brine shrimp (genus Artemia) in the 1950s, this lineage, and in particular the model species Artemia franciscana, has been the subject of extensive research. However, our understanding of the genetic mechanisms underlying various aspects of their reproductive biology, including sex determination, are still lacking. This is partly due to the scarcity of genomic resources for Artemia species and crustaceans in general. Here, we present a chromosome-level genome assembly of Artemia franciscana (Kellogg 1906), from the Great Salt Lake, USA. The genome is 1GB, and the majority of the genome (81%) is scaffolded into 21 linkage groups using a previously published high-density linkage map. We performed coverage and FST analyses using male and female genomic and transcriptomic reads to quantify the extent of differentiation between the Z and W chromosomes. Additionally, we quantified the expression levels in male and female heads and gonads and found further evidence for dosage compensation in this species.","lang":"eng"}],"ddc":["576"],"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png","short":"CC BY (4.0)","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"date_updated":"2025-07-24T11:06:43Z","department":[{"_id":"GradSch"},{"_id":"BeVi"}],"citation":{"mla":"Elkrewi, Marwan N. <i>Data from “Chromosome-Level Assembly of Artemia Franciscana Sheds Light on Sex-Chromosome Differentiation.”</i> Institute of Science and Technology Austria, 2024, doi:<a href=\"https://doi.org/10.15479/AT:ISTA:14705\">10.15479/AT:ISTA:14705</a>.","short":"M.N. Elkrewi, (2024).","ieee":"M. N. Elkrewi, “Data from ‘Chromosome-level assembly of Artemia franciscana sheds light on sex-chromosome differentiation.’” Institute of Science and Technology Austria, 2024.","apa":"Elkrewi, M. N. (2024). Data from “Chromosome-level assembly of Artemia franciscana sheds light on sex-chromosome differentiation.” Institute of Science and Technology Austria. <a href=\"https://doi.org/10.15479/AT:ISTA:14705\">https://doi.org/10.15479/AT:ISTA:14705</a>","chicago":"Elkrewi, Marwan N. “Data from ‘Chromosome-Level Assembly of Artemia Franciscana Sheds Light on Sex-Chromosome Differentiation.’” Institute of Science and Technology Austria, 2024. <a href=\"https://doi.org/10.15479/AT:ISTA:14705\">https://doi.org/10.15479/AT:ISTA:14705</a>.","ama":"Elkrewi MN. Data from “Chromosome-level assembly of Artemia franciscana sheds light on sex-chromosome differentiation.” 2024. doi:<a href=\"https://doi.org/10.15479/AT:ISTA:14705\">10.15479/AT:ISTA:14705</a>","ista":"Elkrewi MN. 2024. Data from ‘Chromosome-level assembly of Artemia franciscana sheds light on sex-chromosome differentiation’, Institute of Science and Technology Austria, <a href=\"https://doi.org/10.15479/AT:ISTA:14705\">10.15479/AT:ISTA:14705</a>."},"status":"public","license":"https://creativecommons.org/licenses/by/4.0/","date_created":"2023-12-22T13:40:48Z","type":"research_data","_id":"14705","retracted":"1","article_processing_charge":"No","month":"01","has_accepted_license":"1","file":[{"content_type":"text/plain","date_updated":"2023-12-22T13:54:21Z","date_created":"2023-12-22T13:54:21Z","file_name":"readme.txt.txt","relation":"main_file","success":1,"creator":"melkrewi","file_id":"14707","checksum":"bdaf1392867786634ec5466d528c36ca","file_size":847,"access_level":"open_access"},{"file_name":"data_artemia_franciscana_genome.zip","date_updated":"2023-12-22T14:14:06Z","date_created":"2023-12-22T14:14:06Z","content_type":"application/x-zip-compressed","file_size":343632753,"access_level":"open_access","creator":"melkrewi","file_id":"14708","checksum":"973e1cbdab923a71709782177980829f","relation":"main_file","success":1}],"author":[{"orcid":"0000-0002-5328-7231","first_name":"Marwan N","last_name":"Elkrewi","full_name":"Elkrewi, Marwan N","id":"0B46FACA-A8E1-11E9-9BD3-79D1E5697425"}],"project":[{"name":"The highjacking of meiosis for asexual reproduction","grant_number":"F8810","_id":"34ae1506-11ca-11ed-8bc3-c14f4c474396"}],"oa_version":"Published Version","contributor":[{"last_name":"Bett","first_name":"Vincent K","id":"57854184-AAE0-11E9-8D04-98D6E5697425","contributor_type":"researcher"},{"last_name":"Macon","first_name":"Ariana","id":"2A0848E2-F248-11E8-B48F-1D18A9856A87","contributor_type":"project_member"},{"id":"49E1C5C6-F248-11E8-B48F-1D18A9856A87","contributor_type":"supervisor","first_name":"Beatriz","last_name":"Vicoso","orcid":"0000-0002-4579-8306"},{"id":"0B46FACA-A8E1-11E9-9BD3-79D1E5697425","contributor_type":"researcher","first_name":"Marwan N","last_name":"Elkrewi","orcid":"0000-0002-5328-7231"}]},{"year":"2024","doi":"10.15479/at:ista:14711","page":"183","day":"19","oa":1,"related_material":{"record":[{"id":"10658","relation":"part_of_dissertation","status":"public"},{"relation":"part_of_dissertation","id":"10787","status":"public"},{"id":"14732","relation":"part_of_dissertation","status":"public"}]},"supervisor":[{"full_name":"Barton, Nicholas H","id":"4880FE40-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-8548-5240","first_name":"Nicholas H","last_name":"Barton"},{"last_name":"Polechova","first_name":"Jitka","full_name":"Polechova, Jitka"},{"last_name":"Sachdeva","first_name":"Himani","full_name":"Sachdeva, Himani"}],"degree_awarded":"MS","tmp":{"name":"Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)","short":"CC BY-NC-SA (4.0)","image":"/images/cc_by_nc_sa.png","legal_code_url":"https://creativecommons.org/licenses/by-nc-sa/4.0/legalcode"},"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","alternative_title":["ISTA Thesis"],"date_updated":"2025-05-26T09:05:10Z","department":[{"_id":"NiBa"},{"_id":"GradSch"}],"date_published":"2024-01-19T00:00:00Z","file_date_updated":"2024-01-03T18:31:34Z","publisher":"Institute of Science and Technology Austria","title":"Local adaptation, genetic load and extinction in metapopulations","abstract":[{"lang":"eng","text":"In nature, different species find their niche in a range of environments, each with its unique characteristics. While some thrive in uniform (homogeneous) landscapes where environmental conditions stay relatively consistent across space, others traverse the complexities of spatially heterogeneous terrains. Comprehending how species are distributed and how they interact within these landscapes holds the key to gaining insights into their evolutionary dynamics while also informing conservation and management strategies.\r\n\r\nFor species inhabiting heterogeneous landscapes, when the rate of dispersal is low compared to spatial fluctuations in selection pressure, localized adaptations may emerge. Such adaptation in response to varying selection strengths plays an important role in the persistence of populations in our rapidly changing world. Hence, species in nature are continuously in a struggle to adapt to local environmental conditions, to ensure their continued survival. Natural populations can often adapt in time scales short enough for evolutionary changes to influence ecological dynamics and vice versa, thereby creating a feedback between evolution and demography. The analysis of this feedback and the relative contributions of gene flow, demography, drift, and natural selection to genetic variation and differentiation has remained a recurring theme in evolutionary biology. Nevertheless, the effective role of these forces in maintaining variation and shaping patterns of diversity is not fully understood. Even in homogeneous environments devoid of local adaptations, such understanding remains elusive. Understanding this feedback is crucial, for example in determining the conditions under which extinction risk can be mitigated in peripheral populations subject to deleterious mutation accumulation at the edges of species’ ranges\r\nas well as in highly fragmented populations.\r\n\r\nIn this thesis we explore both uniform and spatially heterogeneous metapopulations, investigating and providing theoretical insights into the dynamics of local adaptation in the latter and examining the dynamics of load and extinction as well as the impact of joint ecological and evolutionary (eco-evolutionary) dynamics in the former. The thesis is divided into 5 chapters.\r\n\r\nChapter 1 provides a general introduction into the subject matter, clarifying concepts and ideas used throughout the thesis. In chapter 2, we explore how fast a species distributed across a heterogeneous landscape adapts to changing conditions marked by alterations in carrying capacity, selection pressure, and migration rate.\r\n\r\nIn chapter 3, we investigate how migration selection and drift influences adaptation and the maintenance of variation in a metapopulation with three habitats, an extension of previous models of adaptation in two habitats. We further develop analytical approximations for the critical threshold required for polymorphism to persist.\r\n\r\nThe focus of chapter 4 of the thesis is on understanding the interplay between ecology and evolution as coupled processes. We investigate how eco-evolutionary feedback between migration, selection, drift, and demography influences eco-evolutionary outcomes in marginal populations subject to deleterious mutation accumulation. Using simulations as well as theoretical approximations of the coupled dynamics of population size and allele frequency, we analyze how gene flow from a large mainland source influences genetic load and population size on an island (i.e., in a marginal population) under genetically realistic assumptions. Analyses of this sort are important because small isolated populations, are repeatedly affected by complex interactions between ecological and evolutionary processes, which can lead to their death. Understanding these interactions can therefore provide an insight into the conditions under which extinction risk can be mitigated in peripheral populations thus, contributing to conservation and restoration efforts.\r\n\r\nChapter 5 extends the analysis in chapter 4 to consider the dynamics of load (due to deleterious mutation accumulation) and extinction risk in a metapopulation. We explore the role of gene flow, selection, and dominance on load and extinction risk and further pinpoint critical thresholds required for metapopulation persistence.\r\n\r\nOverall this research contributes to our understanding of ecological and evolutionary mechanisms that shape species’ persistence in fragmented landscapes, a crucial foundation for successful conservation efforts and biodiversity management."}],"publication_status":"published","ddc":["576"],"status":"public","license":"https://creativecommons.org/licenses/by-nc-sa/4.0/","publication_identifier":{"issn":["2663 - 337X"]},"date_created":"2023-12-26T22:49:53Z","_id":"14711","type":"dissertation","ec_funded":1,"author":[{"id":"41AD96DC-F248-11E8-B48F-1D18A9856A87","full_name":"Olusanya, Oluwafunmilola O","first_name":"Oluwafunmilola O","last_name":"Olusanya","orcid":"0000-0003-1971-8314"}],"project":[{"grant_number":"665385","_id":"2564DBCA-B435-11E9-9278-68D0E5697425","name":"International IST Doctoral Program","call_identifier":"H2020"},{"name":"Causes and consequences of population fragmentation","_id":"c08d3278-5a5b-11eb-8a69-fdb09b55f4b8","grant_number":"P32896"},{"name":"Polygenic Adaptation in a Metapopulation","grant_number":"26380","_id":"34c872fe-11ca-11ed-8bc3-8534b82131e6"}],"oa_version":"Published Version","language":[{"iso":"eng"}],"article_processing_charge":"No","acknowledged_ssus":[{"_id":"SSU"}],"has_accepted_license":"1","month":"01","file":[{"relation":"source_file","file_size":16986244,"access_level":"closed","creator":"oolusany","file_id":"14730","checksum":"de179b1c6758f182ff0c70d8b38c1501","date_updated":"2024-01-03T18:30:13Z","date_created":"2024-01-03T18:30:13Z","content_type":"application/zip","file_name":"FinalSubmission_Thesis_OLUSANYA.zip"},{"file_size":6460403,"access_level":"open_access","creator":"oolusany","file_id":"14731","checksum":"0e331585e3cd4823320aab4e69e64ccf","success":1,"relation":"main_file","file_name":"FinalSubmission2_Thesis_OLUSANYA.pdf","date_updated":"2024-01-03T18:31:34Z","date_created":"2024-01-03T18:31:34Z","content_type":"application/pdf"}]},{"oa":1,"acknowledgement":"This   project   has   received   funding   from   the   Euro-pean  Research  Council  (ERC)  under  the  EuropeanUnion’s  Horizon  2020  research  and  innovation  programme  (Grant  agreement  No.   101019564  “The  De-sign  of  Modern  Fully  Dynamic  Data  Structures  (Mo-DynStruct)”  and  the  Austrian  Science  Fund  (FWF)project Z 422-N, project “Static and Dynamic Hierar-chical  Graph  Decompositions”,  I  5982-N,  and  project“Fast  Algorithms  for  a  Reactive  Network  Layer  (Re-actNet)”, P 33775-N, with additional funding from thenetidee SCIENCE Stiftung, 2020–2024.D.  Sauplic  has  received  funding  from  the  Euro-pean  Union’s  Horizon  2020  research  and  innovation programme under the Marie Sklodowska-Curie    grant    agreementNo 101034413.","page":"220-233","day":"04","year":"2024","doi":"10.1137/1.9781611977929.17","scopus_import":"1","arxiv":1,"publication":"2024 Proceedings of the Symposium on Algorithm Engineering and Experiments","date_updated":"2025-07-15T12:51:52Z","department":[{"_id":"MoHe"}],"citation":{"mla":"Henzinger, Monika H., et al. “Experimental Evaluation of Fully Dynamic K-Means via Coresets.” <i>2024 Proceedings of the Symposium on Algorithm Engineering and Experiments</i>, Society for Industrial &#38; Applied Mathematics, 2024, pp. 220–33, doi:<a href=\"https://doi.org/10.1137/1.9781611977929.17\">10.1137/1.9781611977929.17</a>.","short":"M.H. Henzinger, D. Saulpic, L. Sidl, in:, 2024 Proceedings of the Symposium on Algorithm Engineering and Experiments, Society for Industrial &#38; Applied Mathematics, 2024, pp. 220–233.","ista":"Henzinger MH, Saulpic D, Sidl L. 2024. Experimental evaluation of fully dynamic k-means via coresets. 2024 Proceedings of the Symposium on Algorithm Engineering and Experiments. ALENEX: Workshop on Algorithm Engineering and Experiments, 220–233.","chicago":"Henzinger, Monika H, David Saulpic, and Leonhard Sidl. “Experimental Evaluation of Fully Dynamic K-Means via Coresets.” In <i>2024 Proceedings of the Symposium on Algorithm Engineering and Experiments</i>, 220–33. Society for Industrial &#38; Applied Mathematics, 2024. <a href=\"https://doi.org/10.1137/1.9781611977929.17\">https://doi.org/10.1137/1.9781611977929.17</a>.","ama":"Henzinger MH, Saulpic D, Sidl L. Experimental evaluation of fully dynamic k-means via coresets. In: <i>2024 Proceedings of the Symposium on Algorithm Engineering and Experiments</i>. Society for Industrial &#38; Applied Mathematics; 2024:220-233. doi:<a href=\"https://doi.org/10.1137/1.9781611977929.17\">10.1137/1.9781611977929.17</a>","apa":"Henzinger, M. H., Saulpic, D., &#38; Sidl, L. (2024). Experimental evaluation of fully dynamic k-means via coresets. In <i>2024 Proceedings of the Symposium on Algorithm Engineering and Experiments</i> (pp. 220–233). Alexandria, VA, United States: Society for Industrial &#38; Applied Mathematics. <a href=\"https://doi.org/10.1137/1.9781611977929.17\">https://doi.org/10.1137/1.9781611977929.17</a>","ieee":"M. H. Henzinger, D. Saulpic, and L. Sidl, “Experimental evaluation of fully dynamic k-means via coresets,” in <i>2024 Proceedings of the Symposium on Algorithm Engineering and Experiments</i>, Alexandria, VA, United States, 2024, pp. 220–233."},"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","external_id":{"arxiv":["2310.18034"]},"abstract":[{"lang":"eng","text":"For a set of points in Rd, the Euclidean k-means problems consists of finding k centers such that the sum of distances squared from each data point to its closest center is minimized. Coresets are one the main tools developed recently to solve this problem in a big data context. They allow to compress the initial dataset while preserving its structure: running any algorithm on the coreset provides a guarantee almost equivalent to running it on the full data. In this work, we study coresets in a fully-dynamic setting: points are added and deleted with the goal to efficiently maintain a coreset with which a k-means solution can be computed. Based on an algorithm from Henzinger and Kale [ESA'20], we present an efficient and practical implementation of a fully dynamic coreset algorithm, that improves the running time by up to a factor of 20 compared to our non-optimized implementation of the algorithm by Henzinger and Kale, without sacrificing more than 7% on the quality of the k-means solution."}],"publication_status":"published","date_published":"2024-01-04T00:00:00Z","publisher":"Society for Industrial & Applied Mathematics","title":"Experimental evaluation of fully dynamic k-means via coresets","date_created":"2024-01-09T16:22:47Z","_id":"14769","type":"conference","main_file_link":[{"open_access":"1","url":"https://doi.org/10.48550/arXiv.2310.18034"}],"publication_identifier":{"eisbn":["9781611977929"]},"status":"public","ec_funded":1,"conference":{"start_date":"2024-01-07","end_date":"2024-01-08","location":"Alexandria, VA, United States","name":"ALENEX: Workshop on Algorithm Engineering and Experiments"},"project":[{"call_identifier":"H2020","grant_number":"101019564","_id":"bd9ca328-d553-11ed-ba76-dc4f890cfe62","name":"The design and evaluation of modern fully dynamic data structures"},{"_id":"34def286-11ca-11ed-8bc3-da5948e1613c","grant_number":"Z00422","name":"Wittgenstein Award - Monika Henzinger"},{"_id":"bda196b2-d553-11ed-ba76-8e8ee6c21103","grant_number":"I05982","name":"Static and Dynamic Hierarchical Graph Decompositions"},{"_id":"bd9e3a2e-d553-11ed-ba76-8aa684ce17fe","grant_number":"P33775 ","name":"Fast Algorithms for a Reactive Network Layer"},{"_id":"fc2ed2f7-9c52-11eb-aca3-c01059dda49c","grant_number":"101034413","name":"IST-BRIDGE: International postdoctoral program","call_identifier":"H2020"}],"quality_controlled":"1","oa_version":"Preprint","author":[{"id":"540c9bbd-f2de-11ec-812d-d04a5be85630","full_name":"Henzinger, Monika H","first_name":"Monika H","last_name":"Henzinger","orcid":"0000-0002-5008-6530"},{"last_name":"Saulpic","first_name":"David","full_name":"Saulpic, David","id":"f8e48cf0-b0ff-11ed-b0e9-b4c35598f964"},{"first_name":"Leonhard","last_name":"Sidl","id":"8b563fd0-b441-11ee-9101-a3891c61efa6","full_name":"Sidl, Leonhard"}],"month":"01","language":[{"iso":"eng"}],"article_processing_charge":"No"},{"volume":5,"article_processing_charge":"Yes","acknowledged_ssus":[{"_id":"Bio"},{"_id":"PreCl"}],"language":[{"iso":"eng"}],"article_number":"102795","issue":"1","month":"01","author":[{"id":"38853E16-F248-11E8-B48F-1D18A9856A87","full_name":"Hansen, Andi H","first_name":"Andi H","last_name":"Hansen"},{"first_name":"Simon","last_name":"Hippenmeyer","orcid":"0000-0003-2279-1061","id":"37B36620-F248-11E8-B48F-1D18A9856A87","full_name":"Hippenmeyer, Simon"}],"oaworkID":1,"oa_version":"Published Version","project":[{"grant_number":"24812","_id":"2625A13E-B435-11E9-9278-68D0E5697425","name":"Molecular Mechanisms of Radial Neuronal Migration"}],"quality_controlled":"1","main_file_link":[{"open_access":"1","url":"https://doi.org/10.1016/j.xpro.2023.102795"}],"status":"public","publication_identifier":{"eissn":["2666-1667"]},"article_type":"review","type":"journal_article","_id":"14794","date_created":"2024-01-14T23:00:56Z","title":"Time-lapse imaging of cortical projection neuron migration in mice using mosaic analysis with double markers","pmid":1,"publisher":"Elsevier","date_published":"2024-01-01T00:00:00Z","publication_status":"epub_ahead","abstract":[{"text":"Mosaic analysis with double markers (MADM) technology enables the sparse labeling of genetically defined neurons. We present a protocol for time-lapse imaging of cortical projection neuron migration in mice using MADM. We describe steps for the isolation, culturing, and 4D imaging of neuronal dynamics in MADM-labeled brain tissue. While this protocol is compatible with other single-cell labeling methods, the MADM approach provides a genetic platform for the functional assessment of cell-autonomous candidate gene function and the relative contribution of non-cell-autonomous effects.\r\n\r\nFor complete details on the use and execution of this protocol, please refer to Hansen et al. (2022),1 Contreras et al. (2021),2 and Amberg and Hippenmeyer (2021).3","lang":"eng"}],"external_id":{"oaworkID":["34426698 "],"pmid":["38165800"]},"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","citation":{"ieee":"A. H. Hansen and S. Hippenmeyer, “Time-lapse imaging of cortical projection neuron migration in mice using mosaic analysis with double markers,” <i>STAR Protocols</i>, vol. 5, no. 1. Elsevier, 2024.","ama":"Hansen AH, Hippenmeyer S. Time-lapse imaging of cortical projection neuron migration in mice using mosaic analysis with double markers. <i>STAR Protocols</i>. 2024;5(1). doi:<a href=\"https://doi.org/10.1016/j.xpro.2023.102795\">10.1016/j.xpro.2023.102795</a>","chicago":"Hansen, Andi H, and Simon Hippenmeyer. “Time-Lapse Imaging of Cortical Projection Neuron Migration in Mice Using Mosaic Analysis with Double Markers.” <i>STAR Protocols</i>. Elsevier, 2024. <a href=\"https://doi.org/10.1016/j.xpro.2023.102795\">https://doi.org/10.1016/j.xpro.2023.102795</a>.","ista":"Hansen AH, Hippenmeyer S. 2024. Time-lapse imaging of cortical projection neuron migration in mice using mosaic analysis with double markers. STAR Protocols. 5(1), 102795.","apa":"Hansen, A. H., &#38; Hippenmeyer, S. (2024). Time-lapse imaging of cortical projection neuron migration in mice using mosaic analysis with double markers. <i>STAR Protocols</i>. Elsevier. <a href=\"https://doi.org/10.1016/j.xpro.2023.102795\">https://doi.org/10.1016/j.xpro.2023.102795</a>","mla":"Hansen, Andi H., and Simon Hippenmeyer. “Time-Lapse Imaging of Cortical Projection Neuron Migration in Mice Using Mosaic Analysis with Double Markers.” <i>STAR Protocols</i>, vol. 5, no. 1, 102795, Elsevier, 2024, doi:<a href=\"https://doi.org/10.1016/j.xpro.2023.102795\">10.1016/j.xpro.2023.102795</a>.","short":"A.H. Hansen, S. Hippenmeyer, STAR Protocols 5 (2024)."},"department":[{"_id":"SiHi"}],"date_updated":"2025-08-11T11:49:30Z","publication":"STAR Protocols","intvolume":"         5","scopus_import":"1","related_material":{"link":[{"url":"http://github.com/hippenmeyerlab","relation":"software"}]},"year":"2024","doi":"10.1016/j.xpro.2023.102795","day":"01","acknowledgement":"We thank Florian Pauler for discussion and his expert technical support. This research was supported by the Scientific Service Units (SSU) at IST Austria through resources provided by the Imaging and Optics Facility (IOF) and Preclinical Facility (PCF). A.H.H. was a recipient of a DOC Fellowship (24812) of the Austrian Academy of Sciences.","oa":1},{"language":[{"iso":"eng"}],"volume":34,"acknowledged_ssus":[{"_id":"Bio"},{"_id":"PreCl"}],"article_processing_charge":"Yes (via OA deal)","has_accepted_license":"1","month":"01","file":[{"date_created":"2024-01-16T10:53:31Z","date_updated":"2024-01-16T10:53:31Z","content_type":"application/pdf","file_name":"2024_CurrentBiology_Arslan.pdf","relation":"main_file","success":1,"access_level":"open_access","file_size":5183861,"file_id":"14813","checksum":"51220b76d72a614208f84bdbfbaf9b72","creator":"dernst"}],"issue":"1","author":[{"id":"49DA7910-F248-11E8-B48F-1D18A9856A87","full_name":"Arslan, Feyza N","first_name":"Feyza N","last_name":"Arslan","orcid":"0000-0001-5809-9566"},{"id":"3A9DB764-F248-11E8-B48F-1D18A9856A87","full_name":"Hannezo, Edouard B","first_name":"Edouard B","last_name":"Hannezo","orcid":"0000-0001-6005-1561"},{"first_name":"Jack","last_name":"Merrin","orcid":"0000-0001-5145-4609","id":"4515C308-F248-11E8-B48F-1D18A9856A87","full_name":"Merrin, Jack"},{"full_name":"Loose, Martin","id":"462D4284-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0001-7309-9724","last_name":"Loose","first_name":"Martin"},{"id":"39427864-F248-11E8-B48F-1D18A9856A87","full_name":"Heisenberg, Carl-Philipp J","last_name":"Heisenberg","first_name":"Carl-Philipp J","orcid":"0000-0002-0912-4566"}],"quality_controlled":"1","project":[{"name":"Interaction and feedback between cell mechanics and fate specification in vertebrate gastrulation","_id":"260F1432-B435-11E9-9278-68D0E5697425","grant_number":"742573","call_identifier":"H2020"}],"oa_version":"Published Version","ec_funded":1,"publication_identifier":{"eissn":["1879-0445"],"issn":["0960-9822"]},"status":"public","date_created":"2024-01-14T23:00:56Z","article_type":"original","type":"journal_article","_id":"14795","publisher":"Elsevier","file_date_updated":"2024-01-16T10:53:31Z","date_published":"2024-01-08T00:00:00Z","title":"Adhesion-induced cortical flows pattern E-cadherin-mediated cell contacts","publication_status":"published","abstract":[{"lang":"eng","text":"Metazoan development relies on the formation and remodeling of cell-cell contacts. Dynamic reorganization of adhesion receptors and the actomyosin cell cortex in space and time plays a central role in cell-cell contact formation and maturation. Nevertheless, how this process is mechanistically achieved when new contacts are formed remains unclear. Here, by building a biomimetic assay composed of progenitor cells adhering to supported lipid bilayers functionalized with E-cadherin ectodomains, we show that cortical F-actin flows, driven by the depletion of myosin-2 at the cell contact center, mediate the dynamic reorganization of adhesion receptors and cell cortex at the contact. E-cadherin-dependent downregulation of the small GTPase RhoA at the forming contact leads to both a depletion of myosin-2 and a decrease of F-actin at the contact center. At the contact rim, in contrast, myosin-2 becomes enriched by the retraction of bleb-like protrusions, resulting in a cortical tension gradient from the contact rim to its center. This tension gradient, in turn, triggers centrifugal F-actin flows, leading to further accumulation of F-actin at the contact rim and the progressive redistribution of E-cadherin from the contact center to the rim. Eventually, this combination of actomyosin downregulation and flows at the contact determines the characteristic molecular organization, with E-cadherin and F-actin accumulating at the contact rim, where they are needed to mechanically link the contractile cortices of the adhering cells."}],"ddc":["570"],"external_id":{"arxiv":["2410.03589"]},"tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png","short":"CC BY (4.0)","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","department":[{"_id":"CaHe"},{"_id":"EdHa"},{"_id":"MaLo"},{"_id":"NanoFab"}],"date_updated":"2025-07-22T14:58:27Z","citation":{"mla":"Arslan, Feyza N., et al. “Adhesion-Induced Cortical Flows Pattern E-Cadherin-Mediated Cell Contacts.” <i>Current Biology</i>, vol. 34, no. 1, Elsevier, 2024, p. 171–182.e8, doi:<a href=\"https://doi.org/10.1016/j.cub.2023.11.067\">10.1016/j.cub.2023.11.067</a>.","short":"F.N. Arslan, E.B. Hannezo, J. Merrin, M. Loose, C.-P.J. Heisenberg, Current Biology 34 (2024) 171–182.e8.","ieee":"F. N. Arslan, E. B. Hannezo, J. Merrin, M. Loose, and C.-P. J. Heisenberg, “Adhesion-induced cortical flows pattern E-cadherin-mediated cell contacts,” <i>Current Biology</i>, vol. 34, no. 1. Elsevier, p. 171–182.e8, 2024.","apa":"Arslan, F. N., Hannezo, E. B., Merrin, J., Loose, M., &#38; Heisenberg, C.-P. J. (2024). Adhesion-induced cortical flows pattern E-cadherin-mediated cell contacts. <i>Current Biology</i>. Elsevier. <a href=\"https://doi.org/10.1016/j.cub.2023.11.067\">https://doi.org/10.1016/j.cub.2023.11.067</a>","ista":"Arslan FN, Hannezo EB, Merrin J, Loose M, Heisenberg C-PJ. 2024. Adhesion-induced cortical flows pattern E-cadherin-mediated cell contacts. Current Biology. 34(1), 171–182.e8.","ama":"Arslan FN, Hannezo EB, Merrin J, Loose M, Heisenberg C-PJ. Adhesion-induced cortical flows pattern E-cadherin-mediated cell contacts. <i>Current Biology</i>. 2024;34(1):171-182.e8. doi:<a href=\"https://doi.org/10.1016/j.cub.2023.11.067\">10.1016/j.cub.2023.11.067</a>","chicago":"Arslan, Feyza N, Edouard B Hannezo, Jack Merrin, Martin Loose, and Carl-Philipp J Heisenberg. “Adhesion-Induced Cortical Flows Pattern E-Cadherin-Mediated Cell Contacts.” <i>Current Biology</i>. Elsevier, 2024. <a href=\"https://doi.org/10.1016/j.cub.2023.11.067\">https://doi.org/10.1016/j.cub.2023.11.067</a>."},"arxiv":1,"intvolume":"        34","publication":"Current Biology","scopus_import":"1","corr_author":"1","acknowledgement":"We are grateful to Edwin Munro for their feedback and help with the single particle analysis. We thank members of the Heisenberg and Loose labs for their help and feedback on the manuscript, notably Xin Tong for making the PCS2-mCherry-AHPH plasmid. Finally, we thank the Aquatics and Imaging & Optics facilities of ISTA for their continuous support, especially Yann Cesbron for assistance with the laser cutter. This work was supported by an ERC\r\nAdvanced Grant (MECSPEC) to C.-P.H.","day":"08","year":"2024","page":"171-182.e8","doi":"10.1016/j.cub.2023.11.067","oa":1},{"year":"2024","day":"04","doi":"10.1007/s00440-023-01254-0","acknowledgement":"NC has received funding from the European Research Council (ERC) under the European Union’s Horizon 2020 research and innovation programme (Grant agreement No 948819).\r\nFM is supported by the Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) through the SPP 2265 Random Geometric Systems. FM has been funded by the Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) under Germany’s Excellence Strategy EXC 2044 -390685587, Mathematics Münster: Dynamics–Geometry–Structure. FM has been funded by the Max Planck Institute for Mathematics in the Sciences.","oa":1,"publication":"Probability Theory and Related Fields","arxiv":1,"scopus_import":"1","keyword":["Troll","Norway","Fjell"],"tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png","short":"CC BY (4.0)","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","external_id":{"arxiv":["2303.00353"]},"citation":{"short":"N. Clozeau, F. Mattesini, Probability Theory and Related Fields (2024).","mla":"Clozeau, Nicolas, and Francesco Mattesini. “Annealed Quantitative Estimates for the Quadratic 2D-Discrete Random Matching Problem.” <i>Probability Theory and Related Fields</i>, Springer Nature, 2024, doi:<a href=\"https://doi.org/10.1007/s00440-023-01254-0\">10.1007/s00440-023-01254-0</a>.","chicago":"Clozeau, Nicolas, and Francesco Mattesini. “Annealed Quantitative Estimates for the Quadratic 2D-Discrete Random Matching Problem.” <i>Probability Theory and Related Fields</i>. Springer Nature, 2024. <a href=\"https://doi.org/10.1007/s00440-023-01254-0\">https://doi.org/10.1007/s00440-023-01254-0</a>.","ista":"Clozeau N, Mattesini F. 2024. Annealed quantitative estimates for the quadratic 2D-discrete random matching problem. Probability Theory and Related Fields.","ama":"Clozeau N, Mattesini F. Annealed quantitative estimates for the quadratic 2D-discrete random matching problem. <i>Probability Theory and Related Fields</i>. 2024. doi:<a href=\"https://doi.org/10.1007/s00440-023-01254-0\">10.1007/s00440-023-01254-0</a>","apa":"Clozeau, N., &#38; Mattesini, F. (2024). Annealed quantitative estimates for the quadratic 2D-discrete random matching problem. <i>Probability Theory and Related Fields</i>. Springer Nature. <a href=\"https://doi.org/10.1007/s00440-023-01254-0\">https://doi.org/10.1007/s00440-023-01254-0</a>","ieee":"N. Clozeau and F. Mattesini, “Annealed quantitative estimates for the quadratic 2D-discrete random matching problem,” <i>Probability Theory and Related Fields</i>. Springer Nature, 2024."},"date_updated":"2025-08-12T12:22:41Z","department":[{"_id":"JuFi"}],"title":"Annealed quantitative estimates for the quadratic 2D-discrete random matching problem","publisher":"Springer Nature","date_published":"2024-01-04T00:00:00Z","ddc":["510"],"abstract":[{"lang":"eng","text":"We study a random matching problem on closed compact  2 -dimensional Riemannian manifolds (with respect to the squared Riemannian distance), with samples of random points whose common law is absolutely continuous with respect to the volume measure with strictly positive and bounded density. We show that given two sequences of numbers  n  and  m=m(n)  of points, asymptotically equivalent as  n  goes to infinity, the optimal transport plan between the two empirical measures  μn  and  νm  is quantitatively well-approximated by  (Id,exp(∇hn))#μn  where  hn  solves a linear elliptic PDE obtained by a regularized first-order linearization of the Monge-Ampère equation. This is obtained in the case of samples of correlated random points for which a stretched exponential decay of the  α -mixing coefficient holds and for a class of discrete-time Markov chains having a unique absolutely continuous invariant measure with respect to the volume measure."}],"publication_status":"epub_ahead","status":"public","publication_identifier":{"issn":["0178-8051"],"eissn":["1432-2064"]},"main_file_link":[{"open_access":"1","url":"https://doi.org/10.1007/s00440-023-01254-0"}],"_id":"14797","type":"journal_article","article_type":"original","date_created":"2024-01-14T23:00:57Z","ec_funded":1,"author":[{"id":"fea1b376-906f-11eb-847d-b2c0cf46455b","full_name":"Clozeau, Nicolas","first_name":"Nicolas","last_name":"Clozeau"},{"first_name":"Francesco","last_name":"Mattesini","full_name":"Mattesini, Francesco"}],"oa_version":"Published Version","quality_controlled":"1","project":[{"name":"Bridging Scales in Random Materials","grant_number":"948819","_id":"0aa76401-070f-11eb-9043-b5bb049fa26d","call_identifier":"H2020"}],"article_processing_charge":"Yes (in subscription journal)","language":[{"iso":"eng"}],"month":"01","has_accepted_license":"1"},{"acknowledgement":"We thank Rishabh Sahu and Sebastian Wald for technical contributions to the experiment. Funding by Institute of Science and Technology Austria.","day":"20","doi":"10.1364/optica.507451","page":"26-31","year":"2024","oa":1,"arxiv":1,"intvolume":"        11","publication":"Optica","keyword":["Atomic and Molecular Physics","and Optics","Electronic","Optical and Magnetic Materials"],"external_id":{"arxiv":["2202.13212"]},"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png","short":"CC BY (4.0)","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"department":[{"_id":"OnHo"}],"date_updated":"2024-08-19T09:52:20Z","date_published":"2024-01-20T00:00:00Z","file_date_updated":"2024-01-17T08:53:16Z","publisher":"Optica Publishing Group","title":"Laser-cavity locking utilizing beam ellipticity: accessing the 10<sup>−7</sup> instability scale relative to cavity linewidth","publication_status":"published","abstract":[{"lang":"eng","text":"Frequency-stable lasers form the back bone of precision measurements in science and technology. Such lasers typically attain their stability through frequency locking to reference cavities. State-of-the-art locking performances to date had been achieved using frequency modulation based methods, complemented with active drift cancellation systems. We demonstrate an all passive, modulation-free laser-cavity locking technique (squash locking) that utilizes changes in spatial beam ellipticity for error signal generation, and a coherent polarization post-selection for noise resilience. By comparing two identically built proof-of-principle systems, we show a frequency locking instability of 5×10<jats:sup>−7</jats:sup> relative to the cavity linewidth at 10 s averaging. The results surpass the demonstrated performances of methods engineered over the last five decades, potentially enabling an advancement in the precision control of lasers, while creating avenues for bridging the performance gaps between industrial grade lasers with scientific ones due to the afforded simplicity and scalability."}],"ddc":["530"],"status":"public","publication_identifier":{"issn":["2334-2536"]},"date_created":"2024-01-15T10:25:38Z","article_type":"original","type":"journal_article","_id":"14802","author":[{"full_name":"Diorico, Fritz R","id":"2E054C4C-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-4947-8924","last_name":"Diorico","first_name":"Fritz R"},{"last_name":"Zhutov","first_name":"Artem","full_name":"Zhutov, Artem","id":"0f02ed6a-b514-11ee-b891-8379c5f19cb7"},{"last_name":"Hosten","first_name":"Onur","orcid":"0000-0002-2031-204X","id":"4C02D85E-F248-11E8-B48F-1D18A9856A87","full_name":"Hosten, Onur"}],"quality_controlled":"1","oa_version":"Published Version","language":[{"iso":"eng"}],"volume":11,"article_processing_charge":"Yes","has_accepted_license":"1","month":"01","file":[{"relation":"main_file","success":1,"access_level":"open_access","file_size":4558986,"checksum":"eb99ca7d0fe73e22f121875175546ed7","file_id":"14824","creator":"dernst","date_created":"2024-01-17T08:53:16Z","date_updated":"2024-01-17T08:53:16Z","content_type":"application/pdf","file_name":"2023_Optica_Diorico.pdf"}],"issue":"1"},{"supervisor":[{"full_name":"Csicsvari, Jozsef L","id":"3FA14672-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-5193-4036","last_name":"Csicsvari","first_name":"Jozsef L"}],"doi":"10.15479/at:ista:14821","year":"2024","page":"89","day":"19","publication_status":"published","ddc":["570"],"file_date_updated":"2024-01-19T11:04:05Z","date_published":"2024-01-19T00:00:00Z","publisher":"Institute of Science and Technology Austria","title":"Adaptive hierarchical representations in the hippocampus","department":[{"_id":"GradSch"},{"_id":"JoCs"}],"date_updated":"2024-02-01T09:50:29Z","citation":{"mla":"Chiossi, Heloisa S. C. <i>Adaptive Hierarchical Representations in the Hippocampus</i>. Institute of Science and Technology Austria, 2024, doi:<a href=\"https://doi.org/10.15479/at:ista:14821\">10.15479/at:ista:14821</a>.","short":"H.S.C. Chiossi, Adaptive Hierarchical Representations in the Hippocampus, Institute of Science and Technology Austria, 2024.","ieee":"H. S. C. Chiossi, “Adaptive hierarchical representations in the hippocampus,” Institute of Science and Technology Austria, 2024.","apa":"Chiossi, H. S. C. (2024). <i>Adaptive hierarchical representations in the hippocampus</i>. Institute of Science and Technology Austria. <a href=\"https://doi.org/10.15479/at:ista:14821\">https://doi.org/10.15479/at:ista:14821</a>","ista":"Chiossi HSC. 2024. Adaptive hierarchical representations in the hippocampus. Institute of Science and Technology Austria.","chicago":"Chiossi, Heloisa S. C. “Adaptive Hierarchical Representations in the Hippocampus.” Institute of Science and Technology Austria, 2024. <a href=\"https://doi.org/10.15479/at:ista:14821\">https://doi.org/10.15479/at:ista:14821</a>.","ama":"Chiossi HSC. Adaptive hierarchical representations in the hippocampus. 2024. doi:<a href=\"https://doi.org/10.15479/at:ista:14821\">10.15479/at:ista:14821</a>"},"degree_awarded":"PhD","alternative_title":["ISTA Thesis"],"user_id":"8b945eb4-e2f2-11eb-945a-df72226e66a9","ec_funded":1,"date_created":"2024-01-16T14:25:21Z","_id":"14821","type":"dissertation","status":"public","publication_identifier":{"issn":["2663 - 337X"]},"has_accepted_license":"1","month":"01","file":[{"file_name":"PhD_Thesis_190124.docx","content_type":"application/vnd.openxmlformats-officedocument.wordprocessingml.document","date_created":"2024-01-19T11:04:05Z","date_updated":"2024-01-19T11:04:05Z","file_id":"14838","checksum":"d3fa3de1abd5af5204c13e9d55375615","creator":"hchiossi","access_level":"closed","file_size":8656268,"relation":"source_file"},{"file_size":6567275,"access_level":"closed","creator":"hchiossi","checksum":"13adc8dcfb5b6b18107f89f0a98fa8bd","file_id":"14839","embargo":"2025-01-19","relation":"main_file","embargo_to":"open_access","file_name":"PhD_Thesis_190124.pdf","date_updated":"2024-01-19T11:03:59Z","date_created":"2024-01-19T11:03:59Z","content_type":"application/pdf"}],"language":[{"iso":"eng"}],"article_processing_charge":"No","project":[{"call_identifier":"H2020","name":"International IST Doctoral Program","grant_number":"665385","_id":"2564DBCA-B435-11E9-9278-68D0E5697425"}],"oa_version":"Published Version","author":[{"first_name":"Heloisa","last_name":"Chiossi","id":"2BBA502C-F248-11E8-B48F-1D18A9856A87","full_name":"Chiossi, Heloisa"}]},{"intvolume":"       187","publication":"Cell","scopus_import":"1","keyword":["General Biochemistry","Genetics and Molecular Biology"],"acknowledgement":"We are grateful to Asuka Shitaku and Eri Koide for generating and sharing the Marchantia PRAF-mCitrine line and Peng-Cheng Wang for sharing the Arabidopsis raf mutant. We are grateful to our team members for discussions and helpful advice. This work was supported by funding from the Netherlands Organization for Scientific Research (NWO): VICI grant 865.14.001 and ENW-KLEIN OCENW.KLEIN.027 grants to D.W.; VENI grant VI.VENI.212.003 to A.K.; the European Research Council AdG DIRNDL (contract number 833867) to D.W.; CoG CATCH to J.S.; StG CELLONGATE (contract 803048) to M.F.; and AdG ETAP (contract 742985) to J.F.; MEXT KAKENHI grant number JP19H05675 to T.K.; JSPS KAKENHI grant number JP20H03275 to R.N.; Takeda Science Foundation to R.N.; and the Austrian Science Fund (FWF, P29988) to J.F.","day":"04","year":"2024","page":"130-148.e17","doi":"10.1016/j.cell.2023.11.021","oa":1,"date_published":"2024-01-04T00:00:00Z","file_date_updated":"2024-01-22T13:41:41Z","publisher":"Elsevier","pmid":1,"title":"RAF-like protein kinases mediate a deeply conserved, rapid auxin response","abstract":[{"lang":"eng","text":"The plant-signaling molecule auxin triggers fast and slow cellular responses across land plants and algae. The nuclear auxin pathway mediates gene expression and controls growth and development in land plants, but this pathway is absent from algal sister groups. Several components of rapid responses have been identified in Arabidopsis, but it is unknown if these are part of a conserved mechanism. We recently identified a fast, proteome-wide phosphorylation response to auxin. Here, we show that this response occurs across 5 land plant and algal species and converges on a core group of shared targets. We found conserved rapid physiological responses to auxin in the same species and identified rapidly accelerated fibrosarcoma (RAF)-like protein kinases as central mediators of auxin-triggered phosphorylation across species. Genetic analysis connects this kinase to both auxin-triggered protein phosphorylation and rapid cellular response, thus identifying an ancient mechanism for fast auxin responses in the green lineage."}],"publication_status":"published","ddc":["580"],"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","tmp":{"name":"Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0)","short":"CC BY-NC (4.0)","legal_code_url":"https://creativecommons.org/licenses/by-nc/4.0/legalcode","image":"/images/cc_by_nc.png"},"external_id":{"pmid":["38128538"]},"date_updated":"2024-01-22T13:43:40Z","department":[{"_id":"JiFr"}],"citation":{"chicago":"Kuhn, Andre, Mark Roosjen, Sumanth Mutte, Shiv Mani Dubey, Vanessa Polet Carrillo Carrasco, Sjef Boeren, Aline Monzer, et al. “RAF-like Protein Kinases Mediate a Deeply Conserved, Rapid Auxin Response.” <i>Cell</i>. Elsevier, 2024. <a href=\"https://doi.org/10.1016/j.cell.2023.11.021\">https://doi.org/10.1016/j.cell.2023.11.021</a>.","ama":"Kuhn A, Roosjen M, Mutte S, et al. RAF-like protein kinases mediate a deeply conserved, rapid auxin response. <i>Cell</i>. 2024;187(1):130-148.e17. doi:<a href=\"https://doi.org/10.1016/j.cell.2023.11.021\">10.1016/j.cell.2023.11.021</a>","ista":"Kuhn A, Roosjen M, Mutte S, Dubey SM, Carrillo Carrasco VP, Boeren S, Monzer A, Koehorst J, Kohchi T, Nishihama R, Fendrych M, Sprakel J, Friml J, Weijers D. 2024. RAF-like protein kinases mediate a deeply conserved, rapid auxin response. Cell. 187(1), 130–148.e17.","apa":"Kuhn, A., Roosjen, M., Mutte, S., Dubey, S. M., Carrillo Carrasco, V. P., Boeren, S., … Weijers, D. (2024). RAF-like protein kinases mediate a deeply conserved, rapid auxin response. <i>Cell</i>. Elsevier. <a href=\"https://doi.org/10.1016/j.cell.2023.11.021\">https://doi.org/10.1016/j.cell.2023.11.021</a>","ieee":"A. Kuhn <i>et al.</i>, “RAF-like protein kinases mediate a deeply conserved, rapid auxin response,” <i>Cell</i>, vol. 187, no. 1. Elsevier, p. 130–148.e17, 2024.","mla":"Kuhn, Andre, et al. “RAF-like Protein Kinases Mediate a Deeply Conserved, Rapid Auxin Response.” <i>Cell</i>, vol. 187, no. 1, Elsevier, 2024, p. 130–148.e17, doi:<a href=\"https://doi.org/10.1016/j.cell.2023.11.021\">10.1016/j.cell.2023.11.021</a>.","short":"A. Kuhn, M. Roosjen, S. Mutte, S.M. Dubey, V.P. Carrillo Carrasco, S. Boeren, A. Monzer, J. Koehorst, T. Kohchi, R. Nishihama, M. Fendrych, J. Sprakel, J. Friml, D. Weijers, Cell 187 (2024) 130–148.e17."},"ec_funded":1,"status":"public","license":"https://creativecommons.org/licenses/by-nc/4.0/","publication_identifier":{"issn":["0092-8674"],"eissn":["1097-4172"]},"date_created":"2024-01-17T12:45:40Z","_id":"14826","type":"journal_article","article_type":"original","language":[{"iso":"eng"}],"article_processing_charge":"Yes (in subscription journal)","volume":187,"month":"01","has_accepted_license":"1","issue":"1","file":[{"access_level":"open_access","file_size":13194060,"file_id":"14874","checksum":"06fd236a9ee0b46ccb05f44695bfc34b","creator":"dernst","success":1,"relation":"main_file","file_name":"2024_Cell_Kuhn.pdf","date_created":"2024-01-22T13:41:41Z","date_updated":"2024-01-22T13:41:41Z","content_type":"application/pdf"}],"author":[{"last_name":"Kuhn","first_name":"Andre","full_name":"Kuhn, Andre"},{"full_name":"Roosjen, Mark","first_name":"Mark","last_name":"Roosjen"},{"last_name":"Mutte","first_name":"Sumanth","full_name":"Mutte, Sumanth"},{"first_name":"Shiv Mani","last_name":"Dubey","full_name":"Dubey, Shiv Mani"},{"last_name":"Carrillo Carrasco","first_name":"Vanessa Polet","full_name":"Carrillo Carrasco, Vanessa Polet"},{"last_name":"Boeren","first_name":"Sjef","full_name":"Boeren, Sjef"},{"last_name":"Monzer","first_name":"Aline","id":"2DB5D88C-D7B3-11E9-B8FD-7907E6697425","full_name":"Monzer, Aline"},{"first_name":"Jasper","last_name":"Koehorst","full_name":"Koehorst, Jasper"},{"full_name":"Kohchi, Takayuki","last_name":"Kohchi","first_name":"Takayuki"},{"last_name":"Nishihama","first_name":"Ryuichi","full_name":"Nishihama, Ryuichi"},{"full_name":"Fendrych, Matyas","id":"43905548-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-9767-8699","last_name":"Fendrych","first_name":"Matyas"},{"last_name":"Sprakel","first_name":"Joris","full_name":"Sprakel, Joris"},{"id":"4159519E-F248-11E8-B48F-1D18A9856A87","full_name":"Friml, Jiří","last_name":"Friml","first_name":"Jiří","orcid":"0000-0002-8302-7596"},{"full_name":"Weijers, Dolf","first_name":"Dolf","last_name":"Weijers"}],"project":[{"call_identifier":"H2020","grant_number":"742985","_id":"261099A6-B435-11E9-9278-68D0E5697425","name":"Tracing Evolution of Auxin Transport and Polarity in Plants"},{"call_identifier":"FWF","name":"RNA-directed DNA methylation in plant development","grant_number":"P29988","_id":"262EF96E-B435-11E9-9278-68D0E5697425"}],"quality_controlled":"1","oa_version":"Published Version"},{"publication_identifier":{"issn":["2574-0962"]},"status":"public","type":"journal_article","_id":"14828","article_type":"original","date_created":"2024-01-17T12:48:35Z","author":[{"full_name":"Kiran, Gundegowda Kalligowdanadoddi","last_name":"Kiran","first_name":"Gundegowda Kalligowdanadoddi"},{"full_name":"Singh, Saurabh","id":"12d625da-9cb3-11ed-9667-af09d37d3f0a","orcid":"0000-0003-2209-5269","last_name":"Singh","first_name":"Saurabh"},{"last_name":"Mahato","first_name":"Neelima","full_name":"Mahato, Neelima"},{"last_name":"Sreekanth","first_name":"Thupakula Venkata Madhukar","full_name":"Sreekanth, Thupakula Venkata Madhukar"},{"first_name":"Gowra Raghupathy","last_name":"Dillip","full_name":"Dillip, Gowra Raghupathy"},{"last_name":"Yoo","first_name":"Kisoo","full_name":"Yoo, Kisoo"},{"full_name":"Kim, Jonghoon","last_name":"Kim","first_name":"Jonghoon"}],"oa_version":"None","oaworkID":1,"quality_controlled":"1","article_processing_charge":"No","volume":7,"language":[{"iso":"eng"}],"issue":"1","month":"01","day":"08","year":"2024","doi":"10.1021/acsaem.3c02519","page":"214-229","acknowledgement":"This work was supported by the Technology Innovation Program (20011622, Development of Battery System Applied High-Efficiency Heat Control Polymer and Part Component) funded by the Ministry of Trade, Industry & Energy (MOTIE, Korea). Author acknowledge to Prof. Tsunehiro Takeuchi from Toyota Technological Institute, Nagoya, Japan for the support of computational resources.","publication":"ACS Applied Energy Materials","intvolume":"         7","keyword":["Electrical and Electronic Engineering","Materials Chemistry","Electrochemistry","Energy Engineering and Power Technology","Chemical Engineering (miscellaneous)"],"scopus_import":"1","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","external_id":{"oaworkID":["w4389780443"],"isi":["001138342900001"]},"citation":{"ieee":"G. K. Kiran <i>et al.</i>, “Interface engineering modulation combined with electronic structure modification of Zn-doped NiO heterostructure for efficient water-splitting activity,” <i>ACS Applied Energy Materials</i>, vol. 7, no. 1. American Chemical Society, pp. 214–229, 2024.","ista":"Kiran GK, Singh S, Mahato N, Sreekanth TVM, Dillip GR, Yoo K, Kim J. 2024. Interface engineering modulation combined with electronic structure modification of Zn-doped NiO heterostructure for efficient water-splitting activity. ACS Applied Energy Materials. 7(1), 214–229.","ama":"Kiran GK, Singh S, Mahato N, et al. Interface engineering modulation combined with electronic structure modification of Zn-doped NiO heterostructure for efficient water-splitting activity. <i>ACS Applied Energy Materials</i>. 2024;7(1):214-229. doi:<a href=\"https://doi.org/10.1021/acsaem.3c02519\">10.1021/acsaem.3c02519</a>","chicago":"Kiran, Gundegowda Kalligowdanadoddi, Saurabh Singh, Neelima Mahato, Thupakula Venkata Madhukar Sreekanth, Gowra Raghupathy Dillip, Kisoo Yoo, and Jonghoon Kim. “Interface Engineering Modulation Combined with Electronic Structure Modification of Zn-Doped NiO Heterostructure for Efficient Water-Splitting Activity.” <i>ACS Applied Energy Materials</i>. American Chemical Society, 2024. <a href=\"https://doi.org/10.1021/acsaem.3c02519\">https://doi.org/10.1021/acsaem.3c02519</a>.","apa":"Kiran, G. K., Singh, S., Mahato, N., Sreekanth, T. V. M., Dillip, G. R., Yoo, K., &#38; Kim, J. (2024). Interface engineering modulation combined with electronic structure modification of Zn-doped NiO heterostructure for efficient water-splitting activity. <i>ACS Applied Energy Materials</i>. American Chemical Society. <a href=\"https://doi.org/10.1021/acsaem.3c02519\">https://doi.org/10.1021/acsaem.3c02519</a>","short":"G.K. Kiran, S. Singh, N. Mahato, T.V.M. Sreekanth, G.R. Dillip, K. Yoo, J. Kim, ACS Applied Energy Materials 7 (2024) 214–229.","mla":"Kiran, Gundegowda Kalligowdanadoddi, et al. “Interface Engineering Modulation Combined with Electronic Structure Modification of Zn-Doped NiO Heterostructure for Efficient Water-Splitting Activity.” <i>ACS Applied Energy Materials</i>, vol. 7, no. 1, American Chemical Society, 2024, pp. 214–29, doi:<a href=\"https://doi.org/10.1021/acsaem.3c02519\">10.1021/acsaem.3c02519</a>."},"date_updated":"2025-07-22T14:07:29Z","department":[{"_id":"MaIb"}],"title":"Interface engineering modulation combined with electronic structure modification of Zn-doped NiO heterostructure for efficient water-splitting activity","publisher":"American Chemical Society","date_published":"2024-01-08T00:00:00Z","isi":1,"abstract":[{"text":"Production of hydrogen at large scale requires development of non-noble, inexpensive, and high-performing catalysts for constructing water-splitting devices. Herein, we report the synthesis of Zn-doped NiO heterostructure (ZnNiO) catalysts at room temperature via a coprecipitation method followed by drying (at 80 °C, 6 h) and calcination at an elevated temperature of 400 °C for 5 h under three distinct conditions, namely, air, N2, and vacuum. The vacuum-synthesized catalyst demonstrates a low overpotential of 88 mV at −10 mA cm–2 and a small Tafel slope of 73 mV dec–1 suggesting relatively higher charge transfer kinetics for hydrogen evolution reactions (HER) compared with the specimens synthesized under N2 or O2 atmosphere. It also demonstrates an oxygen evolution (OER) overpotential of 260 mV at 10 mA cm–2 with a low Tafel slope of 63 mV dec–1. In a full-cell water-splitting device, the vacuum-synthesized ZnNiO heterostructure demonstrates a cell voltage of 1.94 V at 50 mA cm–2 and shows remarkable stability over 24 h at a high current density of 100 mA cm–2. It is also demonstrated in this study that Zn-doping, surface, and interface engineering in transition-metal oxides play a crucial role in efficient electrocatalytic water splitting. Also, the results obtained from density functional theory (DFT + U = 0–8 eV), where U is the on-site Coulomb repulsion parameter also known as Hubbard U, based electronic structure calculations confirm that Zn doping constructively modifies the electronic structure, in both the valence band and the conduction band, and found to be suitable in tailoring the carrier’s effective masses of electrons and holes. The decrease in electron’s effective masses together with large differences between the effective masses of electrons and holes is noticed, which is found to be mainly responsible for achieving the best water-splitting performance from a 9% Zn-doped NiO sample prepared under vacuum.","lang":"eng"}],"publication_status":"published"},{"department":[{"_id":"MaLo"}],"date_updated":"2024-01-23T08:37:13Z","citation":{"short":"P. Radler, M. Loose, European Journal of Cell Biology 103 (2024).","mla":"Radler, Philipp, and Martin Loose. “A Dynamic Duo: Understanding the Roles of FtsZ and FtsA for Escherichia Coli Cell Division through in Vitro Approaches.” <i>European Journal of Cell Biology</i>, vol. 103, no. 1, 151380, Elsevier, 2024, doi:<a href=\"https://doi.org/10.1016/j.ejcb.2023.151380\">10.1016/j.ejcb.2023.151380</a>.","ama":"Radler P, Loose M. A dynamic duo: Understanding the roles of FtsZ and FtsA for Escherichia coli cell division through in vitro approaches. <i>European Journal of Cell Biology</i>. 2024;103(1). doi:<a href=\"https://doi.org/10.1016/j.ejcb.2023.151380\">10.1016/j.ejcb.2023.151380</a>","chicago":"Radler, Philipp, and Martin Loose. “A Dynamic Duo: Understanding the Roles of FtsZ and FtsA for Escherichia Coli Cell Division through in Vitro Approaches.” <i>European Journal of Cell Biology</i>. Elsevier, 2024. <a href=\"https://doi.org/10.1016/j.ejcb.2023.151380\">https://doi.org/10.1016/j.ejcb.2023.151380</a>.","ista":"Radler P, Loose M. 2024. A dynamic duo: Understanding the roles of FtsZ and FtsA for Escherichia coli cell division through in vitro approaches. European Journal of Cell Biology. 103(1), 151380.","apa":"Radler, P., &#38; Loose, M. (2024). A dynamic duo: Understanding the roles of FtsZ and FtsA for Escherichia coli cell division through in vitro approaches. <i>European Journal of Cell Biology</i>. Elsevier. <a href=\"https://doi.org/10.1016/j.ejcb.2023.151380\">https://doi.org/10.1016/j.ejcb.2023.151380</a>","ieee":"P. Radler and M. Loose, “A dynamic duo: Understanding the roles of FtsZ and FtsA for Escherichia coli cell division through in vitro approaches,” <i>European Journal of Cell Biology</i>, vol. 103, no. 1. Elsevier, 2024."},"external_id":{"pmid":["38218128"]},"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png","short":"CC BY (4.0)","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"publication_status":"epub_ahead","abstract":[{"lang":"eng","text":"Bacteria divide by binary fission. The protein machine responsible for this process is the divisome, a transient assembly of more than 30 proteins in and on the surface of the cytoplasmic membrane. Together, they constrict the cell envelope and remodel the peptidoglycan layer to eventually split the cell into two. For Escherichia coli, most molecular players involved in this process have probably been identified, but obtaining the quantitative information needed for a mechanistic understanding can often not be achieved from experiments in vivo alone. Since the discovery of the Z-ring more than 30 years ago, in vitro reconstitution experiments have been crucial to shed light on molecular processes normally hidden in the complex environment of the living cell. In this review, we summarize how rebuilding the divisome from purified components – or at least parts of it - have been instrumental to obtain the detailed mechanistic understanding of the bacterial cell division machinery that we have today."}],"ddc":["570"],"pmid":1,"date_published":"2024-01-12T00:00:00Z","publisher":"Elsevier","title":"A dynamic duo: Understanding the roles of FtsZ and FtsA for Escherichia coli cell division through in vitro approaches","oa":1,"acknowledgement":"We acknowledge members of the Loose laboratory at ISTA for helpful discussions—in particular M. Kojic for his insightful comments. This work was supported by the Austrian Science Fund (FWF P34607) to M.L.","day":"12","doi":"10.1016/j.ejcb.2023.151380","year":"2024","keyword":["Cell Biology","General Medicine","Histology","Pathology and Forensic Medicine"],"scopus_import":"1","intvolume":"       103","publication":"European Journal of Cell Biology","quality_controlled":"1","project":[{"name":"Understanding bacterial cell division by in vitro\r\nreconstitution","_id":"fc38323b-9c52-11eb-aca3-ff8afb4a011d","grant_number":"P34607"}],"oa_version":"Published Version","author":[{"full_name":"Radler, Philipp","id":"40136C2A-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0001-9198-2182 ","last_name":"Radler","first_name":"Philipp"},{"orcid":"0000-0001-7309-9724","first_name":"Martin","last_name":"Loose","full_name":"Loose, Martin","id":"462D4284-F248-11E8-B48F-1D18A9856A87"}],"month":"01","has_accepted_license":"1","article_number":"151380","issue":"1","language":[{"iso":"eng"}],"volume":103,"article_processing_charge":"Yes","date_created":"2024-01-18T08:16:43Z","article_type":"review","type":"journal_article","_id":"14834","status":"public","main_file_link":[{"url":"https://doi.org/10.1016/j.ejcb.2023.151380","open_access":"1"}],"publication_identifier":{"issn":["0171-9335"]}},{"status":"public","publication_identifier":{"eissn":["1091-6490"]},"date_created":"2024-01-21T23:00:56Z","_id":"14841","type":"journal_article","article_type":"original","ec_funded":1,"author":[{"full_name":"Clatot, Jerome","last_name":"Clatot","first_name":"Jerome"},{"full_name":"Currin, Christopher","id":"e8321fc5-3091-11eb-8a53-83f309a11ac9","orcid":"0000-0002-4809-5059","first_name":"Christopher","last_name":"Currin"},{"first_name":"Qiansheng","last_name":"Liang","full_name":"Liang, Qiansheng"},{"first_name":"Tanadet","last_name":"Pipatpolkai","full_name":"Pipatpolkai, Tanadet"},{"full_name":"Massey, Shavonne L.","last_name":"Massey","first_name":"Shavonne L."},{"full_name":"Helbig, Ingo","first_name":"Ingo","last_name":"Helbig"},{"last_name":"Delemotte","first_name":"Lucie","full_name":"Delemotte, Lucie"},{"first_name":"Tim P","last_name":"Vogels","orcid":"0000-0003-3295-6181","id":"CB6FF8D2-008F-11EA-8E08-2637E6697425","full_name":"Vogels, Tim P"},{"full_name":"Covarrubias, Manuel","last_name":"Covarrubias","first_name":"Manuel"},{"full_name":"Goldberg, Ethan M.","first_name":"Ethan M.","last_name":"Goldberg"}],"project":[{"_id":"0aacfa84-070f-11eb-9043-d7eb2c709234","grant_number":"819603","name":"Learning the shape of synaptic plasticity rules for neuronal architectures and function through machine learning.","call_identifier":"H2020"}],"quality_controlled":"1","oa_version":"None","language":[{"iso":"eng"}],"article_processing_charge":"No","volume":121,"month":"01","issue":"3","article_number":"e2307776121","acknowledgement":"This work was supported by an ERC Consolidator Grant (SYNAPSEEK) to T.P.V., the NOMIS Foundation through the NOMIS Fellowships program at IST Austria to C.B.C., a Jefferson Synaptic Biology Center Pilot Project Grant to M.C., NIH NINDS U54 NS108874 (PI, Alfred L. George), and NIH NINDS R01 NS122887 to E.M.G. The computations were enabled by resources provided by the Swedish National Infrastructure for Computing (SNIC) at the PDC Center for High-Performance Computing, KTH Royal Institute of Technology, partially funded by the Swedish Research Council through grant agreement no. 2018-05973. We thank Akshay Sridhar for the fruitful discussion of the project.","doi":"10.1073/pnas.2307776121","year":"2024","day":"16","intvolume":"       121","publication":"Proceedings of the National Academy of Sciences of the United States of America","related_material":{"link":[{"url":"https://github.com/ChrisCurrin/pv-kcnc2 ","relation":"software"}]},"scopus_import":"1","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","external_id":{"pmid":["38194456"]},"date_updated":"2024-01-23T10:20:40Z","department":[{"_id":"TiVo"}],"citation":{"short":"J. Clatot, C. Currin, Q. Liang, T. Pipatpolkai, S.L. Massey, I. Helbig, L. Delemotte, T.P. Vogels, M. Covarrubias, E.M. Goldberg, Proceedings of the National Academy of Sciences of the United States of America 121 (2024).","mla":"Clatot, Jerome, et al. “A Structurally Precise Mechanism Links an Epilepsy-Associated KCNC2 Potassium Channel Mutation to Interneuron Dysfunction.” <i>Proceedings of the National Academy of Sciences of the United States of America</i>, vol. 121, no. 3, e2307776121, Proceedings of the National Academy of Sciences, 2024, doi:<a href=\"https://doi.org/10.1073/pnas.2307776121\">10.1073/pnas.2307776121</a>.","ieee":"J. Clatot <i>et al.</i>, “A structurally precise mechanism links an epilepsy-associated KCNC2 potassium channel mutation to interneuron dysfunction,” <i>Proceedings of the National Academy of Sciences of the United States of America</i>, vol. 121, no. 3. Proceedings of the National Academy of Sciences, 2024.","chicago":"Clatot, Jerome, Christopher Currin, Qiansheng Liang, Tanadet Pipatpolkai, Shavonne L. Massey, Ingo Helbig, Lucie Delemotte, Tim P Vogels, Manuel Covarrubias, and Ethan M. Goldberg. “A Structurally Precise Mechanism Links an Epilepsy-Associated KCNC2 Potassium Channel Mutation to Interneuron Dysfunction.” <i>Proceedings of the National Academy of Sciences of the United States of America</i>. Proceedings of the National Academy of Sciences, 2024. <a href=\"https://doi.org/10.1073/pnas.2307776121\">https://doi.org/10.1073/pnas.2307776121</a>.","ama":"Clatot J, Currin C, Liang Q, et al. A structurally precise mechanism links an epilepsy-associated KCNC2 potassium channel mutation to interneuron dysfunction. <i>Proceedings of the National Academy of Sciences of the United States of America</i>. 2024;121(3). doi:<a href=\"https://doi.org/10.1073/pnas.2307776121\">10.1073/pnas.2307776121</a>","ista":"Clatot J, Currin C, Liang Q, Pipatpolkai T, Massey SL, Helbig I, Delemotte L, Vogels TP, Covarrubias M, Goldberg EM. 2024. A structurally precise mechanism links an epilepsy-associated KCNC2 potassium channel mutation to interneuron dysfunction. Proceedings of the National Academy of Sciences of the United States of America. 121(3), e2307776121.","apa":"Clatot, J., Currin, C., Liang, Q., Pipatpolkai, T., Massey, S. L., Helbig, I., … Goldberg, E. M. (2024). A structurally precise mechanism links an epilepsy-associated KCNC2 potassium channel mutation to interneuron dysfunction. <i>Proceedings of the National Academy of Sciences of the United States of America</i>. Proceedings of the National Academy of Sciences. <a href=\"https://doi.org/10.1073/pnas.2307776121\">https://doi.org/10.1073/pnas.2307776121</a>"},"date_published":"2024-01-16T00:00:00Z","publisher":"Proceedings of the National Academy of Sciences","pmid":1,"title":"A structurally precise mechanism links an epilepsy-associated KCNC2 potassium channel mutation to interneuron dysfunction","abstract":[{"text":"De novo heterozygous variants in KCNC2 encoding the voltage-gated potassium (K+) channel subunit Kv3.2 are a recently described cause of developmental and epileptic encephalopathy (DEE). A de novo variant in KCNC2 c.374G > A (p.Cys125Tyr) was identified via exome sequencing in a patient with DEE. Relative to wild-type Kv3.2, Kv3.2-p.Cys125Tyr induces K+ currents exhibiting a large hyperpolarizing shift in the voltage dependence of activation, accelerated activation, and delayed deactivation consistent with a relative stabilization of the open conformation, along with increased current density. Leveraging the cryogenic electron microscopy (cryo-EM) structure of Kv3.1, molecular dynamic simulations suggest that a strong π-π stacking interaction between the variant Tyr125 and Tyr156 in the α-6 helix of the T1 domain promotes a relative stabilization of the open conformation of the channel, which underlies the observed gain of function. A multicompartment computational model of a Kv3-expressing parvalbumin-positive cerebral cortex fast-spiking γ-aminobutyric acidergic (GABAergic) interneuron (PV-IN) demonstrates how the Kv3.2-Cys125Tyr variant impairs neuronal excitability and dysregulates inhibition in cerebral cortex circuits to explain the resulting epilepsy.","lang":"eng"}],"publication_status":"published"},{"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","external_id":{"pmid":["38215739"]},"date_updated":"2024-03-05T09:31:24Z","department":[{"_id":"PeJo"},{"_id":"EM-Fac"},{"_id":"RySh"}],"citation":{"mla":"Chen, JingJing, et al. “Developmental Transformation of Ca2+ Channel-Vesicle Nanotopography at a Central GABAergic Synapse.” <i>Neuron</i>, Elsevier, doi:<a href=\"https://doi.org/10.1016/j.neuron.2023.12.002\">10.1016/j.neuron.2023.12.002</a>.","short":"J. Chen, W. Kaufmann, C. Chen,  itaru Arai, O. Kim, R. Shigemoto, P.M. Jonas, Neuron (n.d.).","chicago":"Chen, JingJing, Walter Kaufmann, Chong Chen, itaru Arai, Olena Kim, Ryuichi Shigemoto, and Peter M Jonas. “Developmental Transformation of Ca2+ Channel-Vesicle Nanotopography at a Central GABAergic Synapse.” <i>Neuron</i>. Elsevier, n.d. <a href=\"https://doi.org/10.1016/j.neuron.2023.12.002\">https://doi.org/10.1016/j.neuron.2023.12.002</a>.","ista":"Chen J, Kaufmann W, Chen C, Arai  itaru, Kim O, Shigemoto R, Jonas PM. Developmental transformation of Ca2+ channel-vesicle nanotopography at a central GABAergic synapse. Neuron.","ama":"Chen J, Kaufmann W, Chen C, et al. Developmental transformation of Ca2+ channel-vesicle nanotopography at a central GABAergic synapse. <i>Neuron</i>. doi:<a href=\"https://doi.org/10.1016/j.neuron.2023.12.002\">10.1016/j.neuron.2023.12.002</a>","apa":"Chen, J., Kaufmann, W., Chen, C., Arai,  itaru, Kim, O., Shigemoto, R., &#38; Jonas, P. M. (n.d.). Developmental transformation of Ca2+ channel-vesicle nanotopography at a central GABAergic synapse. <i>Neuron</i>. Elsevier. <a href=\"https://doi.org/10.1016/j.neuron.2023.12.002\">https://doi.org/10.1016/j.neuron.2023.12.002</a>","ieee":"J. Chen <i>et al.</i>, “Developmental transformation of Ca2+ channel-vesicle nanotopography at a central GABAergic synapse,” <i>Neuron</i>. Elsevier."},"publisher":"Elsevier","date_published":"2024-01-11T00:00:00Z","pmid":1,"title":"Developmental transformation of Ca2+ channel-vesicle nanotopography at a central GABAergic synapse","abstract":[{"text":"The coupling between Ca2+ channels and release sensors is a key factor defining the signaling properties of a synapse. However, the coupling nanotopography at many synapses remains unknown, and it is unclear how it changes during development. To address these questions, we examined coupling at the cerebellar inhibitory basket cell (BC)-Purkinje cell (PC) synapse. Biophysical analysis of transmission by paired recording and intracellular pipette perfusion revealed that the effects of exogenous Ca2+ chelators decreased during development, despite constant reliance of release on P/Q-type Ca2+ channels. Structural analysis by freeze-fracture replica labeling (FRL) and transmission electron microscopy (EM) indicated that presynaptic P/Q-type Ca2+ channels formed nanoclusters throughout development, whereas docked vesicles were only clustered at later developmental stages. Modeling suggested a developmental transformation from a more random to a more clustered coupling nanotopography. Thus, presynaptic signaling developmentally approaches a point-to-point configuration, optimizing speed, reliability, and energy efficiency of synaptic transmission.","lang":"eng"}],"publication_status":"inpress","acknowledgement":"We thank Drs. David DiGregorio and Erwin Neher for critically reading an earlier version of the manuscript, Ralf Schneggenburger for helpful discussions, Benjamin Suter and Katharina Lichter for support with image analysis, Chris Wojtan for advice on numerical solution of partial differential equations, Maria Reva for help with Ripley analysis, Alois Schlögl for programming, and Akari Hagiwara and Toshihisa Ohtsuka for anti-ELKS antibody. We are grateful to Florian Marr, Christina Altmutter, and Vanessa Zheden for excellent technical assistance and to Eleftheria Kralli-Beller for manuscript editing. This research was supported by the Scientific Services Units (SSUs) of ISTA (Electron Microscopy Facility, Preclinical Facility, and Machine Shop). The project received funding from the European Research Council (ERC) under the European Union’s Horizon 2020 research and innovation program (grant agreement no. 692692), the Fonds zur Förderung der Wissenschaftlichen Forschung (Z 312-B27, Wittgenstein award; P 36232-B), all to P.J., and a DOC fellowship of the Austrian Academy of Sciences to J.-J.C.","year":"2024","day":"11","doi":"10.1016/j.neuron.2023.12.002","publication":"Neuron","related_material":{"link":[{"relation":"press_release","url":"https://ista.ac.at/en/news/synapses-brought-to-the-point/","description":"News on ISTA Website"}]},"scopus_import":"1","author":[{"full_name":"Chen, JingJing","id":"2C4E65C8-F248-11E8-B48F-1D18A9856A87","first_name":"JingJing","last_name":"Chen"},{"orcid":"0000-0001-9735-5315","last_name":"Kaufmann","first_name":"Walter","full_name":"Kaufmann, Walter","id":"3F99E422-F248-11E8-B48F-1D18A9856A87"},{"last_name":"Chen","first_name":"Chong","full_name":"Chen, Chong","id":"3DFD581A-F248-11E8-B48F-1D18A9856A87"},{"last_name":"Arai","first_name":"Itaru","id":"32A73F6C-F248-11E8-B48F-1D18A9856A87","full_name":"Arai, Itaru"},{"first_name":"Olena","last_name":"Kim","full_name":"Kim, Olena","id":"3F8ABDDA-F248-11E8-B48F-1D18A9856A87"},{"full_name":"Shigemoto, Ryuichi","id":"499F3ABC-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0001-8761-9444","first_name":"Ryuichi","last_name":"Shigemoto"},{"id":"353C1B58-F248-11E8-B48F-1D18A9856A87","full_name":"Jonas, Peter M","last_name":"Jonas","first_name":"Peter M","orcid":"0000-0001-5001-4804"}],"quality_controlled":"1","project":[{"grant_number":"692692","_id":"25B7EB9E-B435-11E9-9278-68D0E5697425","name":"Biophysics and circuit function of a giant cortical glumatergic synapse","call_identifier":"H2020"},{"call_identifier":"FWF","grant_number":"Z00312","_id":"25C5A090-B435-11E9-9278-68D0E5697425","name":"The Wittgenstein Prize"},{"grant_number":"P36232","_id":"bd88be38-d553-11ed-ba76-81d5a70a6ef5","name":"Mechanisms of GABA release in hippocampal circuits"},{"name":"Development of nanodomain coupling between Ca2+ channels and release sensors at a central inhibitory synapse","grant_number":"25383","_id":"26B66A3E-B435-11E9-9278-68D0E5697425"}],"oa_version":"None","language":[{"iso":"eng"}],"acknowledged_ssus":[{"_id":"EM-Fac"},{"_id":"PreCl"},{"_id":"M-Shop"}],"article_processing_charge":"No","month":"01","status":"public","publication_identifier":{"eissn":["1097-4199"],"issn":["0896-6273"]},"date_created":"2024-01-21T23:00:56Z","_id":"14843","type":"journal_article","article_type":"original","ec_funded":1},{"date_created":"2024-01-21T23:00:57Z","article_type":"original","_id":"14845","type":"journal_article","publication_identifier":{"issn":["2469-9950"],"eissn":["2469-9969"]},"status":"public","ec_funded":1,"project":[{"call_identifier":"H2020","name":"Angulon: physics and applications of a new quasiparticle","_id":"2688CF98-B435-11E9-9278-68D0E5697425","grant_number":"801770"},{"grant_number":"754411","_id":"260C2330-B435-11E9-9278-68D0E5697425","name":"ISTplus - Postdoctoral Fellowships","call_identifier":"H2020"}],"quality_controlled":"1","oa_version":"None","author":[{"orcid":"0000-0003-2586-3702","first_name":"Tibor","last_name":"Dome","full_name":"Dome, Tibor","id":"7e3293e2-b9dc-11ee-97a9-cd73400f6994"},{"last_name":"Volosniev","first_name":"Artem","orcid":"0000-0003-0393-5525","id":"37D278BC-F248-11E8-B48F-1D18A9856A87","full_name":"Volosniev, Artem"},{"orcid":"0000-0001-9666-3543","first_name":"Areg","last_name":"Ghazaryan","full_name":"Ghazaryan, Areg","id":"4AF46FD6-F248-11E8-B48F-1D18A9856A87"},{"full_name":"Safari, Laleh","id":"3C325E5E-F248-11E8-B48F-1D18A9856A87","last_name":"Safari","first_name":"Laleh"},{"first_name":"Richard","last_name":"Schmidt","full_name":"Schmidt, Richard"},{"full_name":"Lemeshko, Mikhail","id":"37CB05FA-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-6990-7802","last_name":"Lemeshko","first_name":"Mikhail"}],"month":"01","article_number":"014102","issue":"1","language":[{"iso":"eng"}],"volume":109,"article_processing_charge":"No","acknowledgement":"We would like to thank G. Bighin, I. Cherepanov, E. Paerschke, and E. Yakaboylu for insightful discussions on a wide range of topics. This work has been supported by the European Research Council (ERC) Starting Grant No. 801770 (ANGULON). A.G. and A.G.V. acknowledge support from the European Union’s Horizon 2020 research and innovation\r\nprogram under the Marie Skłodowska-Curie Grant Agreement No. 754411. Numerical calculations were performed on the Euler cluster managed by the HPC team at ETH Zurich.\r\nR.S. acknowledges support by the Deutsche Forschungsgemeinschaft under Germany’s Excellence Strategy Grant No. EXC 2181/1-390900948 (the Heidelberg STRUCTURES Excellence Cluster). T.D. acknowledges support from the Isaac Newton Studentship and the Science and Technology Facilities Council under Grant No. ST/V50659X/1.","day":"01","year":"2024","doi":"10.1103/PhysRevB.109.014102","scopus_import":"1","intvolume":"       109","publication":"Physical Review B","department":[{"_id":"MiLe"}],"date_updated":"2024-01-23T10:51:09Z","citation":{"mla":"Dome, Tibor, et al. “Linear Rotor in an Ideal Bose Gas near the Threshold for Binding.” <i>Physical Review B</i>, vol. 109, no. 1, 014102, American Physical Society, 2024, doi:<a href=\"https://doi.org/10.1103/PhysRevB.109.014102\">10.1103/PhysRevB.109.014102</a>.","short":"T. Dome, A. Volosniev, A. Ghazaryan, L. Safari, R. Schmidt, M. Lemeshko, Physical Review B 109 (2024).","ama":"Dome T, Volosniev A, Ghazaryan A, Safari L, Schmidt R, Lemeshko M. Linear rotor in an ideal Bose gas near the threshold for binding. <i>Physical Review B</i>. 2024;109(1). doi:<a href=\"https://doi.org/10.1103/PhysRevB.109.014102\">10.1103/PhysRevB.109.014102</a>","chicago":"Dome, Tibor, Artem Volosniev, Areg Ghazaryan, Laleh Safari, Richard Schmidt, and Mikhail Lemeshko. “Linear Rotor in an Ideal Bose Gas near the Threshold for Binding.” <i>Physical Review B</i>. American Physical Society, 2024. <a href=\"https://doi.org/10.1103/PhysRevB.109.014102\">https://doi.org/10.1103/PhysRevB.109.014102</a>.","ista":"Dome T, Volosniev A, Ghazaryan A, Safari L, Schmidt R, Lemeshko M. 2024. Linear rotor in an ideal Bose gas near the threshold for binding. Physical Review B. 109(1), 014102.","apa":"Dome, T., Volosniev, A., Ghazaryan, A., Safari, L., Schmidt, R., &#38; Lemeshko, M. (2024). Linear rotor in an ideal Bose gas near the threshold for binding. <i>Physical Review B</i>. American Physical Society. <a href=\"https://doi.org/10.1103/PhysRevB.109.014102\">https://doi.org/10.1103/PhysRevB.109.014102</a>","ieee":"T. Dome, A. Volosniev, A. Ghazaryan, L. Safari, R. Schmidt, and M. Lemeshko, “Linear rotor in an ideal Bose gas near the threshold for binding,” <i>Physical Review B</i>, vol. 109, no. 1. American Physical Society, 2024."},"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","publication_status":"published","abstract":[{"text":"We study a linear rotor in a bosonic bath within the angulon formalism. Our focus is on systems where isotropic or anisotropic impurity-boson interactions support a shallow bound state. To study the fate of the angulon in the vicinity of bound-state formation, we formulate a beyond-linear-coupling angulon Hamiltonian. First, we use it to study attractive, spherically symmetric impurity-boson interactions for which the linear rotor can be mapped onto a static impurity. The well-known polaron formalism provides an adequate description in this limit. Second, we consider anisotropic potentials, and show that the presence of a shallow bound state with pronounced anisotropic character leads to a many-body instability that washes out the angulon dynamics.","lang":"eng"}],"publisher":"American Physical Society","date_published":"2024-01-01T00:00:00Z","title":"Linear rotor in an ideal Bose gas near the threshold for binding"},{"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png","short":"CC BY (4.0)","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"citation":{"short":"S. Caballero Mancebo, R. Shinde, M. Bolger-Munro, M. Peruzzo, G. Szep, I. Steccari, D. Labrousse Arias, V. Zheden, J. Merrin, A. Callan-Jones, R. Voituriez, C.-P.J. Heisenberg, Nature Physics (2024).","mla":"Caballero Mancebo, Silvia, et al. “Friction Forces Determine Cytoplasmic Reorganization and Shape Changes of Ascidian Oocytes upon Fertilization.” <i>Nature Physics</i>, Springer Nature, 2024, doi:<a href=\"https://doi.org/10.1038/s41567-023-02302-1\">10.1038/s41567-023-02302-1</a>.","ieee":"S. Caballero Mancebo <i>et al.</i>, “Friction forces determine cytoplasmic reorganization and shape changes of ascidian oocytes upon fertilization,” <i>Nature Physics</i>. Springer Nature, 2024.","apa":"Caballero Mancebo, S., Shinde, R., Bolger-Munro, M., Peruzzo, M., Szep, G., Steccari, I., … Heisenberg, C.-P. J. (2024). Friction forces determine cytoplasmic reorganization and shape changes of ascidian oocytes upon fertilization. <i>Nature Physics</i>. Springer Nature. <a href=\"https://doi.org/10.1038/s41567-023-02302-1\">https://doi.org/10.1038/s41567-023-02302-1</a>","ama":"Caballero Mancebo S, Shinde R, Bolger-Munro M, et al. Friction forces determine cytoplasmic reorganization and shape changes of ascidian oocytes upon fertilization. <i>Nature Physics</i>. 2024. doi:<a href=\"https://doi.org/10.1038/s41567-023-02302-1\">10.1038/s41567-023-02302-1</a>","ista":"Caballero Mancebo S, Shinde R, Bolger-Munro M, Peruzzo M, Szep G, Steccari I, Labrousse Arias D, Zheden V, Merrin J, Callan-Jones A, Voituriez R, Heisenberg C-PJ. 2024. Friction forces determine cytoplasmic reorganization and shape changes of ascidian oocytes upon fertilization. Nature Physics.","chicago":"Caballero Mancebo, Silvia, Rushikesh Shinde, Madison Bolger-Munro, Matilda Peruzzo, Gregory Szep, Irene Steccari, David Labrousse Arias, et al. “Friction Forces Determine Cytoplasmic Reorganization and Shape Changes of Ascidian Oocytes upon Fertilization.” <i>Nature Physics</i>. Springer Nature, 2024. <a href=\"https://doi.org/10.1038/s41567-023-02302-1\">https://doi.org/10.1038/s41567-023-02302-1</a>."},"department":[{"_id":"CaHe"},{"_id":"JoFi"},{"_id":"MiSi"},{"_id":"EM-Fac"},{"_id":"NanoFab"}],"date_updated":"2024-03-05T09:33:38Z","title":"Friction forces determine cytoplasmic reorganization and shape changes of ascidian oocytes upon fertilization","publisher":"Springer Nature","date_published":"2024-01-09T00:00:00Z","publication_status":"epub_ahead","abstract":[{"text":"Contraction and flow of the actin cell cortex have emerged as a common principle by which cells reorganize their cytoplasm and take shape. However, how these cortical flows interact with adjacent cytoplasmic components, changing their form and localization, and how this affects cytoplasmic organization and cell shape remains unclear. Here we show that in ascidian oocytes, the cooperative activities of cortical actomyosin flows and deformation of the adjacent mitochondria-rich myoplasm drive oocyte cytoplasmic reorganization and shape changes following fertilization. We show that vegetal-directed cortical actomyosin flows, established upon oocyte fertilization, lead to both the accumulation of cortical actin at the vegetal pole of the zygote and compression and local buckling of the adjacent elastic solid-like myoplasm layer due to friction forces generated at their interface. Once cortical flows have ceased, the multiple myoplasm buckles resolve into one larger buckle, which again drives the formation of the contraction pole—a protuberance of the zygote’s vegetal pole where maternal mRNAs accumulate. Thus, our findings reveal a mechanism where cortical actomyosin network flows determine cytoplasmic reorganization and cell shape by deforming adjacent cytoplasmic components through friction forces.","lang":"eng"}],"year":"2024","doi":"10.1038/s41567-023-02302-1","day":"09","acknowledgement":"We would like to thank A. McDougall, E. Hannezo and the Heisenberg lab for fruitful discussions and reagents. We also thank E. Munro for the iMyo-YFP and Bra>iMyo-mScarlet constructs. This research was supported by the Scientific Service Units of the Institute of Science and Technology Austria through resources provided by the Electron Microscopy Facility, Imaging and Optics Facility and the Nanofabrication Facility. This work was supported by a Joint Project Grant from the FWF (I 3601-B27).","oa":1,"publication":"Nature Physics","scopus_import":"1","related_material":{"link":[{"relation":"press_release","url":"https://ista.ac.at/en/news/stranger-than-friction-a-force-initiating-life/","description":"News on ISTA Website"}]},"author":[{"orcid":"0000-0002-5223-3346","first_name":"Silvia","last_name":"Caballero Mancebo","full_name":"Caballero Mancebo, Silvia","id":"2F1E1758-F248-11E8-B48F-1D18A9856A87"},{"last_name":"Shinde","first_name":"Rushikesh","full_name":"Shinde, Rushikesh"},{"full_name":"Bolger-Munro, Madison","id":"516F03FA-93A3-11EA-A7C5-D6BE3DDC885E","orcid":"0000-0002-8176-4824","first_name":"Madison","last_name":"Bolger-Munro"},{"id":"3F920B30-F248-11E8-B48F-1D18A9856A87","full_name":"Peruzzo, Matilda","first_name":"Matilda","last_name":"Peruzzo","orcid":"0000-0002-3415-4628"},{"full_name":"Szep, Gregory","id":"4BFB7762-F248-11E8-B48F-1D18A9856A87","last_name":"Szep","first_name":"Gregory"},{"first_name":"Irene","last_name":"Steccari","full_name":"Steccari, Irene","id":"2705C766-9FE2-11EA-B224-C6773DDC885E"},{"full_name":"Labrousse Arias, David","id":"CD573DF4-9ED3-11E9-9D77-3223E6697425","first_name":"David","last_name":"Labrousse Arias"},{"id":"39C5A68A-F248-11E8-B48F-1D18A9856A87","full_name":"Zheden, Vanessa","first_name":"Vanessa","last_name":"Zheden","orcid":"0000-0002-9438-4783"},{"orcid":"0000-0001-5145-4609","last_name":"Merrin","first_name":"Jack","full_name":"Merrin, Jack","id":"4515C308-F248-11E8-B48F-1D18A9856A87"},{"full_name":"Callan-Jones, Andrew","last_name":"Callan-Jones","first_name":"Andrew"},{"full_name":"Voituriez, Raphaël","first_name":"Raphaël","last_name":"Voituriez"},{"id":"39427864-F248-11E8-B48F-1D18A9856A87","full_name":"Heisenberg, Carl-Philipp J","last_name":"Heisenberg","first_name":"Carl-Philipp J","orcid":"0000-0002-0912-4566"}],"oa_version":"Published Version","quality_controlled":"1","project":[{"_id":"2646861A-B435-11E9-9278-68D0E5697425","grant_number":"I03601","name":"Control of embryonic cleavage pattern","call_identifier":"FWF"}],"article_processing_charge":"Yes (in subscription journal)","acknowledged_ssus":[{"_id":"EM-Fac"},{"_id":"Bio"},{"_id":"NanoFab"}],"language":[{"iso":"eng"}],"month":"01","has_accepted_license":"1","status":"public","publication_identifier":{"eissn":["1745-2481"],"issn":["1745-2473"]},"main_file_link":[{"url":"https://doi.org/10.1038/s41567-023-02302-1","open_access":"1"}],"article_type":"original","_id":"14846","type":"journal_article","date_created":"2024-01-21T23:00:57Z"},{"author":[{"first_name":"Arka","last_name":"Pal","orcid":"0000-0002-4530-8469","id":"6AAB2240-CA9A-11E9-9C1A-D9D1E5697425","full_name":"Pal, Arka"},{"first_name":"Mihir","last_name":"Joshi","full_name":"Joshi, Mihir"},{"full_name":"Thaker, Maria","last_name":"Thaker","first_name":"Maria"}],"quality_controlled":"1","oa_version":"Published Version","language":[{"iso":"eng"}],"article_processing_charge":"Yes (via OA deal)","volume":227,"month":"01","has_accepted_license":"1","issue":"1","file":[{"success":1,"relation":"main_file","file_size":594128,"access_level":"open_access","creator":"dernst","checksum":"136325372f6f45abaa62a71e2d23bfb6","file_id":"14877","date_updated":"2024-01-23T12:08:24Z","date_created":"2024-01-23T12:08:24Z","content_type":"application/pdf","file_name":"2024_JourExperimBiology_Pal.pdf"}],"article_number":"jeb246217","publication_identifier":{"eissn":["0022-0949"],"issn":["1477-9145"]},"status":"public","date_created":"2024-01-22T08:14:49Z","_id":"14850","type":"journal_article","article_type":"original","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png","short":"CC BY (4.0)","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"external_id":{"pmid":["38054353"]},"date_updated":"2024-01-23T12:13:08Z","department":[{"_id":"NiBa"}],"citation":{"chicago":"Pal, Arka, Mihir Joshi, and Maria Thaker. “Too Much Information? Males Convey Parasite Levels Using More Signal Modalities than Females Utilise.” <i>Journal of Experimental Biology</i>. The Company of Biologists, 2024. <a href=\"https://doi.org/10.1242/jeb.246217\">https://doi.org/10.1242/jeb.246217</a>.","ista":"Pal A, Joshi M, Thaker M. 2024. Too much information? Males convey parasite levels using more signal modalities than females utilise. Journal of Experimental Biology. 227(1), jeb246217.","ama":"Pal A, Joshi M, Thaker M. Too much information? Males convey parasite levels using more signal modalities than females utilise. <i>Journal of Experimental Biology</i>. 2024;227(1). doi:<a href=\"https://doi.org/10.1242/jeb.246217\">10.1242/jeb.246217</a>","apa":"Pal, A., Joshi, M., &#38; Thaker, M. (2024). Too much information? Males convey parasite levels using more signal modalities than females utilise. <i>Journal of Experimental Biology</i>. The Company of Biologists. <a href=\"https://doi.org/10.1242/jeb.246217\">https://doi.org/10.1242/jeb.246217</a>","ieee":"A. Pal, M. Joshi, and M. Thaker, “Too much information? Males convey parasite levels using more signal modalities than females utilise,” <i>Journal of Experimental Biology</i>, vol. 227, no. 1. The Company of Biologists, 2024.","short":"A. Pal, M. Joshi, M. Thaker, Journal of Experimental Biology 227 (2024).","mla":"Pal, Arka, et al. “Too Much Information? Males Convey Parasite Levels Using More Signal Modalities than Females Utilise.” <i>Journal of Experimental Biology</i>, vol. 227, no. 1, jeb246217, The Company of Biologists, 2024, doi:<a href=\"https://doi.org/10.1242/jeb.246217\">10.1242/jeb.246217</a>."},"date_published":"2024-01-10T00:00:00Z","publisher":"The Company of Biologists","file_date_updated":"2024-01-23T12:08:24Z","pmid":1,"title":"Too much information? Males convey parasite levels using more signal modalities than females utilise","abstract":[{"lang":"eng","text":"Elaborate sexual signals are thought to have evolved and be maintained to serve as honest indicators of signaller quality. One measure of quality is health, which can be affected by parasite infection. Cnemaspis mysoriensis is a diurnal gecko that is often infested with ectoparasites in the wild, and males of this species express visual (coloured gular patches) and chemical (femoral gland secretions) traits that receivers could assess during social interactions. In this paper, we tested whether ectoparasites affect individual health, and whether signal quality is an indicator of ectoparasite levels. In wild lizards, we found that ectoparasite level was negatively correlated with body condition in both sexes. Moreover, some characteristics of both visual and chemical traits in males were strongly associated with ectoparasite levels. Specifically, males with higher ectoparasite levels had yellow gular patches with lower brightness and chroma, and chemical secretions with a lower proportion of aromatic compounds. We then determined whether ectoparasite levels in males influence female behaviour. Using sequential choice trials, wherein females were provided with either the visual or the chemical signals of wild-caught males that varied in ectoparasite level, we found that only chemical secretions evoked an elevated female response towards less parasitised males. Simultaneous choice trials in which females were exposed to the chemical secretions from males that varied in parasite level further confirmed a preference for males with lower parasites loads. Overall, we find that although health (body condition) or ectoparasite load can be honestly advertised through multiple modalities, the parasite-mediated female response is exclusively driven by chemical signals.</jats:p>"}],"publication_status":"published","ddc":["570"],"acknowledgement":"We thank Anuradha Batabyal and Shakilur Kabir for scientific discussions, and help with sampling and colour analyses. We thank Muralidhar and the central LCMS facility of the IISc for their technical support with the GCMS.\r\nResearch funding was provided by the Department of Science and Technology Fund for Improvement of S&T Infrastructure (DST-FIST), the Department of Biotechnology-Indian Institute of Science (DBT-IISc) partnership program and a Science and Engineering Research Board (SERB) grant to M.T. (EMR/2017/002228). Open Access funding provided by Indian Institute of Science. Deposited in PMC for immediate release.","year":"2024","doi":"10.1242/jeb.246217","day":"10","oa":1,"intvolume":"       227","publication":"Journal of Experimental Biology","related_material":{"link":[{"relation":"software","url":"https://github.com/arka-pal/Cnemaspis-SexualSignaling"}]},"keyword":["Insect Science","Molecular Biology","Animal Science and Zoology","Aquatic Science","Physiology","Ecology","Evolution","Behavior and Systematics"]},{"author":[{"last_name":"Karle","first_name":"Volker","orcid":"0000-0002-6963-0129","id":"D7C012AE-D7ED-11E9-95E8-1EC5E5697425","full_name":"Karle, Volker"},{"id":"37CB05FA-F248-11E8-B48F-1D18A9856A87","full_name":"Lemeshko, Mikhail","last_name":"Lemeshko","first_name":"Mikhail","orcid":"0000-0002-6990-7802"}],"quality_controlled":"1","oa_version":"Published Version","language":[{"iso":"ger"}],"volume":55,"article_processing_charge":"Yes (via OA deal)","month":"01","has_accepted_license":"1","file":[{"success":1,"relation":"main_file","file_size":1155244,"access_level":"open_access","creator":"dernst","checksum":"3051dadcf9bc57da97e36b647c596ab1","file_id":"14878","date_updated":"2024-01-23T12:18:07Z","date_created":"2024-01-23T12:18:07Z","content_type":"application/pdf","file_name":"2024_PhysikZeit_Karle.pdf"}],"issue":"1","status":"public","publication_identifier":{"eissn":["1521-3943"],"issn":["0031-9252"]},"date_created":"2024-01-22T08:19:36Z","article_type":"original","_id":"14851","type":"journal_article","tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png","short":"CC BY (4.0)","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"user_id":"3E5EF7F0-F248-11E8-B48F-1D18A9856A87","department":[{"_id":"MiLe"}],"date_updated":"2024-02-15T14:29:04Z","citation":{"chicago":"Karle, Volker, and Mikhail Lemeshko. “Die faszinierende Topologie rotierender Quanten.” <i>Physik in unserer Zeit</i>. Wiley, 2024. <a href=\"https://doi.org/10.1002/piuz.202301690\">https://doi.org/10.1002/piuz.202301690</a>.","ista":"Karle V, Lemeshko M. 2024. Die faszinierende Topologie rotierender Quanten. Physik in unserer Zeit. 55(1), 28–33.","ama":"Karle V, Lemeshko M. Die faszinierende Topologie rotierender Quanten. <i>Physik in unserer Zeit</i>. 2024;55(1):28-33. doi:<a href=\"https://doi.org/10.1002/piuz.202301690\">10.1002/piuz.202301690</a>","apa":"Karle, V., &#38; Lemeshko, M. (2024). Die faszinierende Topologie rotierender Quanten. <i>Physik in unserer Zeit</i>. Wiley. <a href=\"https://doi.org/10.1002/piuz.202301690\">https://doi.org/10.1002/piuz.202301690</a>","ieee":"V. Karle and M. Lemeshko, “Die faszinierende Topologie rotierender Quanten,” <i>Physik in unserer Zeit</i>, vol. 55, no. 1. Wiley, pp. 28–33, 2024.","mla":"Karle, Volker, and Mikhail Lemeshko. “Die faszinierende Topologie rotierender Quanten.” <i>Physik in unserer Zeit</i>, vol. 55, no. 1, Wiley, 2024, pp. 28–33, doi:<a href=\"https://doi.org/10.1002/piuz.202301690\">10.1002/piuz.202301690</a>.","short":"V. Karle, M. Lemeshko, Physik in unserer Zeit 55 (2024) 28–33."},"file_date_updated":"2024-01-23T12:18:07Z","date_published":"2024-01-01T00:00:00Z","publisher":"Wiley","title":"Die faszinierende Topologie rotierender Quanten","publication_status":"published","abstract":[{"lang":"ger","text":"Die Quantenrotation ist ein spannendes Phänomen, das in vielen verschiedenen Systemen auftritt, von Molekülen und Atomen bis hin zu subatomaren Teilchen wie Neutronen und Protonen. Durch den Einsatz von starken Laserpulsen ist es möglich, die mathematisch anspruchsvolle Topologie der Rotation von Molekülen aufzudecken und topologisch geschützte Zustände zu erzeugen, die unerwartetes Verhalten zeigen. Diese Entdeckungen könnten Auswirkungen auf die Molekülphysik und physikalische Chemie haben und die Entwicklung neuer Technologien ermöglichen. Die Verbindung von Quantenrotation und Topologie stellt ein aufregendes, interdisziplinäres Forschungsfeld dar und bietet neue Wege zur Kontrolle und Nutzung von quantenmechanischen Phänomenen."}],"ddc":["530"],"day":"01","year":"2024","doi":"10.1002/piuz.202301690","page":"28-33","oa":1,"intvolume":"        55","publication":"Physik in unserer Zeit","keyword":["General Earth and Planetary Sciences","General Environmental Science"]},{"citation":{"apa":"Kramarenko, I., Kerutt, J., Verhamme, A., Oesch, P. A., Barrufet, L., Matthee, J. J., … Thai, T. T. (2024). Linking UV spectral properties of MUSE Ly α emitters at <i>z</i> ≳ 3 to Lyman continuum escape. <i>Monthly Notices of the Royal Astronomical Society</i>. Oxford University Press. <a href=\"https://doi.org/10.1093/mnras/stad3853\">https://doi.org/10.1093/mnras/stad3853</a>","ista":"Kramarenko I, Kerutt J, Verhamme A, Oesch PA, Barrufet L, Matthee JJ, Kusakabe H, Goovaerts I, Thai TT. 2024. Linking UV spectral properties of MUSE Ly α emitters at <i>z</i> ≳ 3 to Lyman continuum escape. Monthly Notices of the Royal Astronomical Society. 527(4), 9853–9871.","ama":"Kramarenko I, Kerutt J, Verhamme A, et al. Linking UV spectral properties of MUSE Ly α emitters at <i>z</i> ≳ 3 to Lyman continuum escape. <i>Monthly Notices of the Royal Astronomical Society</i>. 2024;527(4):9853-9871. doi:<a href=\"https://doi.org/10.1093/mnras/stad3853\">10.1093/mnras/stad3853</a>","chicago":"Kramarenko, Ivan, J Kerutt, A Verhamme, P A Oesch, L Barrufet, Jorryt J Matthee, H Kusakabe, I Goovaerts, and T T Thai. “Linking UV Spectral Properties of MUSE Ly α Emitters at <i>z</i> ≳ 3 to Lyman Continuum Escape.” <i>Monthly Notices of the Royal Astronomical Society</i>. Oxford University Press, 2024. <a href=\"https://doi.org/10.1093/mnras/stad3853\">https://doi.org/10.1093/mnras/stad3853</a>.","ieee":"I. Kramarenko <i>et al.</i>, “Linking UV spectral properties of MUSE Ly α emitters at <i>z</i> ≳ 3 to Lyman continuum escape,” <i>Monthly Notices of the Royal Astronomical Society</i>, vol. 527, no. 4. Oxford University Press, pp. 9853–9871, 2024.","mla":"Kramarenko, Ivan, et al. “Linking UV Spectral Properties of MUSE Ly α Emitters at <i>z</i> ≳ 3 to Lyman Continuum Escape.” <i>Monthly Notices of the Royal Astronomical Society</i>, vol. 527, no. 4, Oxford University Press, 2024, pp. 9853–71, doi:<a href=\"https://doi.org/10.1093/mnras/stad3853\">10.1093/mnras/stad3853</a>.","short":"I. Kramarenko, J. Kerutt, A. Verhamme, P.A. Oesch, L. Barrufet, J.J. Matthee, H. Kusakabe, I. Goovaerts, T.T. Thai, Monthly Notices of the Royal Astronomical Society 527 (2024) 9853–9871."},"date_updated":"2024-01-23T12:33:50Z","department":[{"_id":"GradSch"},{"_id":"JoMa"}],"tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png","short":"CC BY (4.0)","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","external_id":{"arxiv":["2305.07044"]},"ddc":["520"],"abstract":[{"text":"The physical conditions giving rise to high escape fractions of ionizing radiation (LyC fesc) in star-forming galaxies – most likely protagonists of cosmic reionization – are not yet fully understood. Using the VLT/MUSE observations of ∼1400 Ly α emitters at 2.9 &amp;lt; z &amp;lt; 6.7, we compare stacked rest-frame UV spectra of candidates for LyC leakers and non-leakers selected based on their Ly α profiles. We find that the stacks of potential LyC leakers, i.e. galaxies with narrow, symmetric Ly α profiles with small peak separation, generally show (i) strong nebular O iii]λ1666, [Si iii]λ1883, and [C iii]λ1907 +C iii]λ1909 emission, indicating a high-ionization state of the interstellar medium (ISM); (ii) high equivalent widths of He iiλ1640 (∼1 − 3 Å), suggesting the presence of hard ionizing radiation fields; (iii) Si ii*λ1533 emission, revealing substantial amounts of neutral hydrogen off the line of sight; (iv) high C ivλλ1548,1550 to [C iii]λ1907 +C iii]λ1909 ratios (C iv/C iii] ≳0.75) , signalling the presence of low column density channels in the ISM. In contrast, the stacks with broad, asymmetric Ly α profiles with large peak separation show weak nebular emission lines, low He iiλ1640 equivalent widths (≲1 Å), and low C iv/C iii] (≲0.25), implying low-ionization states and high-neutral hydrogen column densities. Our results suggest that C iv/C iii] might be sensitive to the physical conditions that govern LyC photon escape, providing a promising tool for identification of ionizing sources among star-forming galaxies in the epoch of reionization.","lang":"eng"}],"publication_status":"published","title":"Linking UV spectral properties of MUSE Ly α emitters at <i>z</i> ≳ 3 to Lyman continuum escape","date_published":"2024-02-01T00:00:00Z","publisher":"Oxford University Press","file_date_updated":"2024-01-23T12:30:45Z","oa":1,"day":"01","page":"9853-9871","year":"2024","doi":"10.1093/mnras/stad3853","acknowledgement":"We thank the anonymous referee for the constructive feedback that helped to improve the manuscript. We thank Michael Maseda, Daniel Schaerer, Charlotte Simmonds, and Rashmi Gottumukkala for useful comments and productive discussions. We also thank the organizers and participants of the 24th MUSE Science Busy Week in Leiden. IGK acknowledges an Excellence Master Fellowship granted by the Faculty of Science of the University of Geneva. This work has received funding from the Swiss State Secretariat for Education, Research and Innovation (SERI) under contract number MB22.00072, as well as from the Swiss National Science Foundation (SNSF) through project grant number 200020_207349 and SNSF Professorship grant number 190079. The Cosmic Dawn Center (DAWN) is funded by the Danish National Research Foundation under grant number 140. This paper is based on observations collected at the European Organisation for Astronomical Research in the Southern Hemisphere under ESO programmes 094.A-0289(B), 095.A-0010(A), 096.A-0045(A), 096.A-0045(B), 094.A-0205, 095.A-0240, 096.A-0090, 097.A-0160, and 098.A-0017. We made extensive use of several open-source software packages and we are thankful to the respective authors for sharing their work: NUMPY (Harris et al. 2020), ASTROPY (Astropy Collaboration 2022), MATPLOTLIB (Hunter 2007), IPYTHON (Perez & Granger 2007), and TOPCAT (Taylor 2005).","keyword":["Space and Planetary Science","Astronomy and Astrophysics"],"publication":"Monthly Notices of the Royal Astronomical Society","intvolume":"       527","arxiv":1,"oa_version":"Published Version","quality_controlled":"1","author":[{"first_name":"Ivan","last_name":"Kramarenko","full_name":"Kramarenko, Ivan","id":"9a9394cb-3200-11ee-973b-f5ba2a8b16e4"},{"full_name":"Kerutt, J","first_name":"J","last_name":"Kerutt"},{"full_name":"Verhamme, A","first_name":"A","last_name":"Verhamme"},{"full_name":"Oesch, P A","first_name":"P A","last_name":"Oesch"},{"last_name":"Barrufet","first_name":"L","full_name":"Barrufet, L"},{"full_name":"Matthee, Jorryt J","id":"7439a258-f3c0-11ec-9501-9df22fe06720","orcid":"0000-0003-2871-127X","first_name":"Jorryt J","last_name":"Matthee"},{"first_name":"H","last_name":"Kusakabe","full_name":"Kusakabe, H"},{"full_name":"Goovaerts, I","last_name":"Goovaerts","first_name":"I"},{"last_name":"Thai","first_name":"T T","full_name":"Thai, T T"}],"issue":"4","file":[{"content_type":"application/pdf","date_created":"2024-01-23T12:30:45Z","date_updated":"2024-01-23T12:30:45Z","file_name":"2024_MNAstronomSoc_Kramarenko.pdf","success":1,"relation":"main_file","checksum":"9d02df4035c4951cf63dee0db1e462e9","file_id":"14879","creator":"dernst","access_level":"open_access","file_size":4521738}],"month":"02","has_accepted_license":"1","article_processing_charge":"Yes (in subscription journal)","volume":527,"language":[{"iso":"eng"}],"type":"journal_article","_id":"14852","article_type":"original","date_created":"2024-01-22T08:22:17Z","status":"public","publication_identifier":{"eissn":["1365-2966"],"issn":["0035-8711"]}},{"date_created":"2024-01-28T23:01:42Z","_id":"14884","type":"journal_article","article_type":"original","publication_identifier":{"eissn":["1432-1467"],"issn":["0938-8974"]},"status":"public","main_file_link":[{"open_access":"1","url":"https://doi.org/10.48550/arXiv.2306.05151"}],"project":[{"name":"Taming Complexity in Partial Differential Systems","grant_number":"F6504","_id":"fc31cba2-9c52-11eb-aca3-ff467d239cd2"}],"quality_controlled":"1","oa_version":"Preprint","author":[{"full_name":"Davoli, Elisa","last_name":"Davoli","first_name":"Elisa"},{"last_name":"D’Elia","first_name":"Lorenza","full_name":"D’Elia, Lorenza"},{"last_name":"Ingmanns","first_name":"Jonas","full_name":"Ingmanns, Jonas","id":"71523d30-15b2-11ec-abd3-f80aa909d6b0"}],"month":"01","issue":"2","article_number":"30","language":[{"iso":"eng"}],"article_processing_charge":"No","volume":34,"oa":1,"acknowledgement":"All authors acknowledge support of the Austrian Science Fund (FWF) through the SFB project F65. The research of E. Davoli and L. D’Elia has additionally been supported by the FWF through grants V662, Y1292, and P35359, as well as from OeAD through the WTZ grant CZ09/2023.","day":"23","doi":"10.1007/s00332-023-10005-3","year":"2024","scopus_import":"1","intvolume":"        34","arxiv":1,"publication":"Journal of Nonlinear Science","date_updated":"2024-02-05T08:54:44Z","department":[{"_id":"JuFi"}],"citation":{"mla":"Davoli, Elisa, et al. “Stochastic Homogenization of Micromagnetic Energies and Emergence of Magnetic Skyrmions.” <i>Journal of Nonlinear Science</i>, vol. 34, no. 2, 30, Springer Nature, 2024, doi:<a href=\"https://doi.org/10.1007/s00332-023-10005-3\">10.1007/s00332-023-10005-3</a>.","short":"E. Davoli, L. D’Elia, J. Ingmanns, Journal of Nonlinear Science 34 (2024).","ieee":"E. Davoli, L. D’Elia, and J. Ingmanns, “Stochastic homogenization of micromagnetic energies and emergence of magnetic skyrmions,” <i>Journal of Nonlinear Science</i>, vol. 34, no. 2. Springer Nature, 2024.","apa":"Davoli, E., D’Elia, L., &#38; Ingmanns, J. (2024). Stochastic homogenization of micromagnetic energies and emergence of magnetic skyrmions. <i>Journal of Nonlinear Science</i>. Springer Nature. <a href=\"https://doi.org/10.1007/s00332-023-10005-3\">https://doi.org/10.1007/s00332-023-10005-3</a>","ista":"Davoli E, D’Elia L, Ingmanns J. 2024. Stochastic homogenization of micromagnetic energies and emergence of magnetic skyrmions. Journal of Nonlinear Science. 34(2), 30.","ama":"Davoli E, D’Elia L, Ingmanns J. Stochastic homogenization of micromagnetic energies and emergence of magnetic skyrmions. <i>Journal of Nonlinear Science</i>. 2024;34(2). doi:<a href=\"https://doi.org/10.1007/s00332-023-10005-3\">10.1007/s00332-023-10005-3</a>","chicago":"Davoli, Elisa, Lorenza D’Elia, and Jonas Ingmanns. “Stochastic Homogenization of Micromagnetic Energies and Emergence of Magnetic Skyrmions.” <i>Journal of Nonlinear Science</i>. Springer Nature, 2024. <a href=\"https://doi.org/10.1007/s00332-023-10005-3\">https://doi.org/10.1007/s00332-023-10005-3</a>."},"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","external_id":{"arxiv":["2306.05151"]},"abstract":[{"text":"We perform a stochastic homogenization analysis for composite materials exhibiting a random microstructure. Under the assumptions of stationarity and ergodicity, we characterize the Gamma-limit of a micromagnetic energy functional defined on magnetizations taking value in the unit sphere and including both symmetric and antisymmetric exchange contributions. This Gamma-limit corresponds to a micromagnetic energy functional with homogeneous coefficients. We provide explicit formulas for the effective magnetic properties of the composite material in terms of homogenization correctors. Additionally, the variational analysis of the two exchange energy terms is performed in the more general setting of functionals defined on manifold-valued maps with Sobolev regularity, in the case in which the target manifold is a bounded, orientable smooth surface with tubular neighborhood of uniform thickness. Eventually, we present an explicit characterization of minimizers of the effective exchange in the case of magnetic multilayers, providing quantitative evidence of Dzyaloshinskii’s predictions on the emergence of helical structures in composite ferromagnetic materials with stochastic microstructure.","lang":"eng"}],"publication_status":"epub_ahead","publisher":"Springer Nature","date_published":"2024-01-23T00:00:00Z","title":"Stochastic homogenization of micromagnetic energies and emergence of magnetic skyrmions"},{"file_date_updated":"2024-02-06T08:38:27Z","date_published":"2024-01-28T00:00:00Z","publisher":"Wiley","title":"Local controls on near-surface glacier cooling under warm atmospheric conditions","abstract":[{"lang":"eng","text":"The near-surface boundary layer can mediate the response of mountain glaciers to external climate, cooling the overlying air and promoting a density-driven glacier wind. The fundamental processes are conceptually well understood, though the magnitudes of cooling and presence of glacier winds are poorly quantified in space and time, increasing the forcing uncertainty for melt models. We utilize a new data set of on-glacier meteorological measurements on three neighboring glaciers in the Swiss Alps to explore their distinct response to regional climate under the extreme 2022 summer. We find that synoptic wind origins and local terrain modifications, not only glacier size, play an important role in the ability of a glacier to cool the near-surface air. Warm air intrusions from valley or synoptically-driven winds onto the glacier can occur between ∼19% and 64% of the time and contribute between 3% and 81% of the total sensible heat flux to the surface during warm afternoon hours, depending on the fetch of the glacier flowline and its susceptibility to boundary layer erosion. In the context of extreme summer warmth, indicative of future conditions, the boundary layer cooling (up to 6.5°C cooler than its surroundings) and resultant katabatic wind flow are highly heterogeneous between the study glaciers, highlighting the complex and likely non-linear response of glaciers to an uncertain future."}],"publication_status":"published","ddc":["550"],"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png","short":"CC BY (4.0)","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"date_updated":"2024-02-06T08:44:02Z","department":[{"_id":"FrPe"}],"citation":{"short":"T. Shaw, P. Buri, M. McCarthy, E.S. Miles, F. Pellicciotti, Journal of Geophysical Research: Atmospheres 129 (2024).","mla":"Shaw, Thomas, et al. “Local Controls on Near-Surface Glacier Cooling under Warm Atmospheric Conditions.” <i>Journal of Geophysical Research: Atmospheres</i>, vol. 129, no. 2, e2023JD040214, Wiley, 2024, doi:<a href=\"https://doi.org/10.1029/2023JD040214\">10.1029/2023JD040214</a>.","ieee":"T. Shaw, P. Buri, M. McCarthy, E. S. Miles, and F. Pellicciotti, “Local controls on near-surface glacier cooling under warm atmospheric conditions,” <i>Journal of Geophysical Research: Atmospheres</i>, vol. 129, no. 2. Wiley, 2024.","apa":"Shaw, T., Buri, P., McCarthy, M., Miles, E. S., &#38; Pellicciotti, F. (2024). Local controls on near-surface glacier cooling under warm atmospheric conditions. <i>Journal of Geophysical Research: Atmospheres</i>. Wiley. <a href=\"https://doi.org/10.1029/2023JD040214\">https://doi.org/10.1029/2023JD040214</a>","ama":"Shaw T, Buri P, McCarthy M, Miles ES, Pellicciotti F. Local controls on near-surface glacier cooling under warm atmospheric conditions. <i>Journal of Geophysical Research: Atmospheres</i>. 2024;129(2). doi:<a href=\"https://doi.org/10.1029/2023JD040214\">10.1029/2023JD040214</a>","ista":"Shaw T, Buri P, McCarthy M, Miles ES, Pellicciotti F. 2024. Local controls on near-surface glacier cooling under warm atmospheric conditions. Journal of Geophysical Research: Atmospheres. 129(2), e2023JD040214.","chicago":"Shaw, Thomas, Pascal Buri, Michael McCarthy, Evan S. Miles, and Francesca Pellicciotti. “Local Controls on Near-Surface Glacier Cooling under Warm Atmospheric Conditions.” <i>Journal of Geophysical Research: Atmospheres</i>. Wiley, 2024. <a href=\"https://doi.org/10.1029/2023JD040214\">https://doi.org/10.1029/2023JD040214</a>."},"intvolume":"       129","publication":"Journal of Geophysical Research: Atmospheres","related_material":{"record":[{"status":"public","relation":"research_data","id":"14919"}]},"scopus_import":"1","acknowledgement":"This project has received funding from the European Union's Horizon 2020 research and innovation programme under the Marie Sklodowska-Curie grant agreement No. 101026058. The authors acknowledge the invaluable field assistance of Marta Corrà, Achille Jouberton, Marin Kneib, Stefan Fugger, Celine Ducret and Alexander Groos. The authors would also like to thank Luca Carturan for advice regarding AWS setup and maintenance and Simone Fatichi for provision and support in the use of the Tethys-Chloris model. Open access funding provided by ETH-Bereich Forschungsanstalten.","doi":"10.1029/2023JD040214","year":"2024","day":"28","oa":1,"language":[{"iso":"eng"}],"article_processing_charge":"Yes (in subscription journal)","volume":129,"has_accepted_license":"1","month":"01","issue":"2","article_number":"e2023JD040214","file":[{"content_type":"application/pdf","date_created":"2024-02-06T08:38:27Z","date_updated":"2024-02-06T08:38:27Z","file_name":"2024_JGRAtmospheres_Shaw.pdf","relation":"main_file","success":1,"checksum":"cad5b93caadb40c14e5faedc34f7bba7","file_id":"14943","creator":"dernst","access_level":"open_access","file_size":7481087}],"author":[{"last_name":"Shaw","first_name":"Thomas","orcid":"0000-0001-7640-6152","id":"3caa3f91-1f03-11ee-96ce-e0e553054d6e","full_name":"Shaw, Thomas"},{"last_name":"Buri","first_name":"Pascal","id":"317987aa-9421-11ee-ac5a-b941b041abba","full_name":"Buri, Pascal"},{"first_name":"Michael","last_name":"Mccarthy","full_name":"Mccarthy, Michael","id":"22a2674a-61ce-11ee-94b5-d18813baf16f"},{"first_name":"Evan S.","last_name":"Miles","full_name":"Miles, Evan S."},{"id":"b28f055a-81ea-11ed-b70c-a9fe7f7b0e70","full_name":"Pellicciotti, Francesca","last_name":"Pellicciotti","first_name":"Francesca","orcid":"0000-0002-5554-8087"}],"quality_controlled":"1","oa_version":"Published Version","publication_identifier":{"issn":["2169-897X"],"eissn":["2169-8996"]},"status":"public","date_created":"2024-01-28T23:01:42Z","_id":"14885","type":"journal_article","article_type":"original"}]