---
_id: '2926'
abstract:
- lang: eng
text: To fight infectious diseases, host immune defenses are employed at multiple
levels. Sanitary behavior, such as pathogen avoidance and removal, acts as a first
line of defense to prevent infection [1] before activation of the physiological
immune system. Insect societies have evolved a wide range of collective hygiene
measures and intensive health care toward pathogen-exposed group members [2].
One of the most common behaviors is allogrooming, in which nestmates remove infectious
particles from the body surfaces of exposed individuals [3]. Here we show that,
in invasive garden ants, grooming of fungus-exposed brood is effective beyond
the sheer mechanical removal of fungal conidiospores; it also includes chemical
disinfection through the application of poison produced by the ants themselves.
Formic acid is the main active component of the poison. It inhibits fungal growth
of conidiospores remaining on the brood surface after grooming and also those
collected in the mouth of the grooming ant. This dual function is achieved by
uptake of the poison droplet into the mouth through acidopore self-grooming and
subsequent application onto the infectious brood via brood grooming. This extraordinary
behavior extends the current understanding of grooming and the establishment of
social immunity in insect societies.
acknowledgement: "Funding for this project was obtained by the German Research Foundation
(DFG, to S.C.) and the European Research Council (ERC, through an ERC-Starting Grant
to S.C. and an Individual Marie Curie IEF fellowship to L.V.U.).\r\nWe thank Jørgen
Eilenberg, Bernhardt Steinwender, Miriam Stock, and Meghan L. Vyleta for the fungal
strain and its characterization; Volker Witte for chemical information; Eva Sixt
for ant drawings; and Robert Hauschild for help with image analysis. We further
thank Martin Kaltenpoth, Michael Sixt, Jürgen Heinze, and Joachim Ruther for discussion
and Daria Siekhaus, Sophie A.O. Armitage, and Leila Masri for comments on the manuscript.
\r\n"
author:
- first_name: Simon
full_name: Tragust, Simon
id: 35A7A418-F248-11E8-B48F-1D18A9856A87
last_name: Tragust
- first_name: Barbara
full_name: Mitteregger, Barbara
id: 479DDAAC-E9CD-11E9-9B5F-82450873F7A1
last_name: Mitteregger
- first_name: Vanessa
full_name: Barone, Vanessa
id: 419EECCC-F248-11E8-B48F-1D18A9856A87
last_name: Barone
orcid: 0000-0003-2676-3367
- first_name: Matthias
full_name: Konrad, Matthias
id: 46528076-F248-11E8-B48F-1D18A9856A87
last_name: Konrad
- first_name: Line V
full_name: Ugelvig, Line V
id: 3DC97C8E-F248-11E8-B48F-1D18A9856A87
last_name: Ugelvig
orcid: 0000-0003-1832-8883
- first_name: Sylvia
full_name: Cremer, Sylvia
id: 2F64EC8C-F248-11E8-B48F-1D18A9856A87
last_name: Cremer
orcid: 0000-0002-2193-3868
citation:
ama: Tragust S, Mitteregger B, Barone V, Konrad M, Ugelvig LV, Cremer S. Ants disinfect
fungus-exposed brood by oral uptake and spread of their poison. Current Biology.
2013;23(1):76-82. doi:10.1016/j.cub.2012.11.034
apa: Tragust, S., Mitteregger, B., Barone, V., Konrad, M., Ugelvig, L. V., &
Cremer, S. (2013). Ants disinfect fungus-exposed brood by oral uptake and spread
of their poison. Current Biology. Cell Press. https://doi.org/10.1016/j.cub.2012.11.034
chicago: Tragust, Simon, Barbara Mitteregger, Vanessa Barone, Matthias Konrad, Line
V Ugelvig, and Sylvia Cremer. “Ants Disinfect Fungus-Exposed Brood by Oral Uptake
and Spread of Their Poison.” Current Biology. Cell Press, 2013. https://doi.org/10.1016/j.cub.2012.11.034.
ieee: S. Tragust, B. Mitteregger, V. Barone, M. Konrad, L. V. Ugelvig, and S. Cremer,
“Ants disinfect fungus-exposed brood by oral uptake and spread of their poison,”
Current Biology, vol. 23, no. 1. Cell Press, pp. 76–82, 2013.
ista: Tragust S, Mitteregger B, Barone V, Konrad M, Ugelvig LV, Cremer S. 2013.
Ants disinfect fungus-exposed brood by oral uptake and spread of their poison.
Current Biology. 23(1), 76–82.
mla: Tragust, Simon, et al. “Ants Disinfect Fungus-Exposed Brood by Oral Uptake
and Spread of Their Poison.” Current Biology, vol. 23, no. 1, Cell Press,
2013, pp. 76–82, doi:10.1016/j.cub.2012.11.034.
short: S. Tragust, B. Mitteregger, V. Barone, M. Konrad, L.V. Ugelvig, S. Cremer,
Current Biology 23 (2013) 76–82.
date_created: 2018-12-11T12:00:23Z
date_published: 2013-01-07T00:00:00Z
date_updated: 2023-09-07T12:05:08Z
day: '07'
department:
- _id: SyCr
- _id: CaHe
doi: 10.1016/j.cub.2012.11.034
ec_funded: 1
intvolume: ' 23'
issue: '1'
language:
- iso: eng
month: '01'
oa_version: None
page: 76 - 82
project:
- _id: 25DAF0B2-B435-11E9-9278-68D0E5697425
grant_number: CR-118/3-1
name: Host-Parasite Coevolution
- _id: 25DC711C-B435-11E9-9278-68D0E5697425
call_identifier: FP7
grant_number: '243071'
name: 'Social Vaccination in Ant Colonies: from Individual Mechanisms to Society
Effects'
- _id: 25DDF0F0-B435-11E9-9278-68D0E5697425
call_identifier: FP7
grant_number: '302004'
name: 'Pathogen Detectors Collective disease defence and pathogen detection abilities
in ant societies: a chemo-neuro-immunological approach'
publication: Current Biology
publication_status: published
publisher: Cell Press
publist_id: '3811'
quality_controlled: '1'
related_material:
record:
- id: '9757'
relation: research_data
status: public
- id: '961'
relation: dissertation_contains
status: public
scopus_import: 1
status: public
title: Ants disinfect fungus-exposed brood by oral uptake and spread of their poison
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 23
year: '2013'
...
---
_id: '2278'
abstract:
- lang: eng
text: It is firmly established that interactions between neurons and glia are fundamental
across species for the correct establishment of a functional brain. Here, we found
that the glia of the Drosophila larval brain display an essential non-autonomous
role during the development of the optic lobe. The optic lobe develops from neuroepithelial
cells that proliferate by dividing symmetrically until they switch to asymmetric/differentiative
divisions that generate neuroblasts. The proneural gene lethal of scute (l9sc)
is transiently activated by the epidermal growth factor receptor (EGFR)-Ras signal
transduction pathway at the leading edge of a proneural wave that sweeps from
medial to lateral neuroepithelium, promoting this switch. This process is tightly
regulated by the tissue-autonomous function within the neuroepithelium of multiple
signaling pathways, including EGFR-Ras and Notch. This study shows that the Notch
ligand Serrate (Ser) is expressed in the glia and it forms a complex in vivo with
Notch and Canoe, which colocalize at the adherens junctions of neuroepithelial
cells. This complex is crucial for interactions between glia and neuroepithelial
cells during optic lobe development. Ser is tissue-autonomously required in the
glia where it activates Notch to regulate its proliferation, and non-autonomously
in the neuroepithelium where Ser induces Notch signaling to avoid the premature
activation of the EGFR-Ras pathway and hence of L9sc. Interestingly, different
Notch activity reporters showed very different expression patterns in the glia
and in the neuroepithelium, suggesting the existence of tissue-specific factors
that promote the expression of particular Notch target genes or/and a reporter
response dependent on different thresholds of Notch signaling.
author:
- first_name: Raquel
full_name: Pérez Gómez, Raquel
last_name: Pérez Gómez
- first_name: Jana
full_name: Slovakova, Jana
id: 30F3F2F0-F248-11E8-B48F-1D18A9856A87
last_name: Slovakova
- first_name: Noemí
full_name: Rives Quinto, Noemí
last_name: Rives Quinto
- first_name: Alena
full_name: Krejčí, Alena
last_name: Krejčí
- first_name: Ana
full_name: Carmena, Ana
last_name: Carmena
citation:
ama: Pérez Gómez R, Slovakova J, Rives Quinto N, Krejčí A, Carmena A. A serrate-notch-canoe
complex mediates essential interactions between glia and neuroepithelial cells
during Drosophila optic lobe development. Journal of Cell Science. 2013;126(21):4873-4884.
doi:10.1242/jcs.125617
apa: Pérez Gómez, R., Slovakova, J., Rives Quinto, N., Krejčí, A., & Carmena,
A. (2013). A serrate-notch-canoe complex mediates essential interactions between
glia and neuroepithelial cells during Drosophila optic lobe development. Journal
of Cell Science. Company of Biologists. https://doi.org/10.1242/jcs.125617
chicago: Pérez Gómez, Raquel, Jana Slovakova, Noemí Rives Quinto, Alena Krejčí,
and Ana Carmena. “A Serrate-Notch-Canoe Complex Mediates Essential Interactions
between Glia and Neuroepithelial Cells during Drosophila Optic Lobe Development.”
Journal of Cell Science. Company of Biologists, 2013. https://doi.org/10.1242/jcs.125617.
ieee: R. Pérez Gómez, J. Slovakova, N. Rives Quinto, A. Krejčí, and A. Carmena,
“A serrate-notch-canoe complex mediates essential interactions between glia and
neuroepithelial cells during Drosophila optic lobe development,” Journal of
Cell Science, vol. 126, no. 21. Company of Biologists, pp. 4873–4884, 2013.
ista: Pérez Gómez R, Slovakova J, Rives Quinto N, Krejčí A, Carmena A. 2013. A serrate-notch-canoe
complex mediates essential interactions between glia and neuroepithelial cells
during Drosophila optic lobe development. Journal of Cell Science. 126(21), 4873–4884.
mla: Pérez Gómez, Raquel, et al. “A Serrate-Notch-Canoe Complex Mediates Essential
Interactions between Glia and Neuroepithelial Cells during Drosophila Optic Lobe
Development.” Journal of Cell Science, vol. 126, no. 21, Company of Biologists,
2013, pp. 4873–84, doi:10.1242/jcs.125617.
short: R. Pérez Gómez, J. Slovakova, N. Rives Quinto, A. Krejčí, A. Carmena, Journal
of Cell Science 126 (2013) 4873–4884.
date_created: 2018-12-11T11:56:43Z
date_published: 2013-11-01T00:00:00Z
date_updated: 2021-01-12T06:56:29Z
day: '01'
department:
- _id: CaHe
doi: 10.1242/jcs.125617
intvolume: ' 126'
issue: '21'
language:
- iso: eng
month: '11'
oa_version: None
page: 4873 - 4884
publication: Journal of Cell Science
publication_status: published
publisher: Company of Biologists
publist_id: '4658'
quality_controlled: '1'
scopus_import: 1
status: public
title: A serrate-notch-canoe complex mediates essential interactions between glia
and neuroepithelial cells during Drosophila optic lobe development
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 126
year: '2013'
...
---
_id: '2282'
abstract:
- lang: eng
text: Epithelial spreading is a common and fundamental aspect of various developmental
and disease-related processes such as epithelial closure and wound healing. A
key challenge for epithelial tissues undergoing spreading is to increase their
surface area without disrupting epithelial integrity. Here we show that orienting
cell divisions by tension constitutes an efficient mechanism by which the enveloping
cell layer (EVL) releases anisotropic tension while undergoing spreading during
zebrafish epiboly. The control of EVL cell-division orientation by tension involves
cell elongation and requires myosin II activity to align the mitotic spindle with
the main tension axis. We also found that in the absence of tension-oriented cell
divisions and in the presence of increased tissue tension, EVL cells undergo ectopic
fusions, suggesting that the reduction of tension anisotropy by oriented cell
divisions is required to prevent EVL cells from fusing. We conclude that cell-division
orientation by tension constitutes a key mechanism for limiting tension anisotropy
and thus promoting tissue spreading during EVL epiboly.
acknowledged_ssus:
- _id: PreCl
- _id: Bio
acknowledgement: 'This work was supported by the IST Austria and MPI-CBG '
author:
- first_name: Pedro
full_name: Campinho, Pedro
id: 3AFBBC42-F248-11E8-B48F-1D18A9856A87
last_name: Campinho
orcid: 0000-0002-8526-5416
- first_name: Martin
full_name: Behrndt, Martin
id: 3ECECA3A-F248-11E8-B48F-1D18A9856A87
last_name: Behrndt
- first_name: Jonas
full_name: Ranft, Jonas
last_name: Ranft
- first_name: Thomas
full_name: Risler, Thomas
last_name: Risler
- first_name: Nicolas
full_name: Minc, Nicolas
last_name: Minc
- first_name: Carl-Philipp J
full_name: Heisenberg, Carl-Philipp J
id: 39427864-F248-11E8-B48F-1D18A9856A87
last_name: Heisenberg
orcid: 0000-0002-0912-4566
citation:
ama: Campinho P, Behrndt M, Ranft J, Risler T, Minc N, Heisenberg C-PJ. Tension-oriented
cell divisions limit anisotropic tissue tension in epithelial spreading during
zebrafish epiboly. Nature Cell Biology. 2013;15:1405-1414. doi:10.1038/ncb2869
apa: Campinho, P., Behrndt, M., Ranft, J., Risler, T., Minc, N., & Heisenberg,
C.-P. J. (2013). Tension-oriented cell divisions limit anisotropic tissue tension
in epithelial spreading during zebrafish epiboly. Nature Cell Biology.
Nature Publishing Group. https://doi.org/10.1038/ncb2869
chicago: Campinho, Pedro, Martin Behrndt, Jonas Ranft, Thomas Risler, Nicolas Minc,
and Carl-Philipp J Heisenberg. “Tension-Oriented Cell Divisions Limit Anisotropic
Tissue Tension in Epithelial Spreading during Zebrafish Epiboly.” Nature Cell
Biology. Nature Publishing Group, 2013. https://doi.org/10.1038/ncb2869.
ieee: P. Campinho, M. Behrndt, J. Ranft, T. Risler, N. Minc, and C.-P. J. Heisenberg,
“Tension-oriented cell divisions limit anisotropic tissue tension in epithelial
spreading during zebrafish epiboly,” Nature Cell Biology, vol. 15. Nature
Publishing Group, pp. 1405–1414, 2013.
ista: Campinho P, Behrndt M, Ranft J, Risler T, Minc N, Heisenberg C-PJ. 2013. Tension-oriented
cell divisions limit anisotropic tissue tension in epithelial spreading during
zebrafish epiboly. Nature Cell Biology. 15, 1405–1414.
mla: Campinho, Pedro, et al. “Tension-Oriented Cell Divisions Limit Anisotropic
Tissue Tension in Epithelial Spreading during Zebrafish Epiboly.” Nature Cell
Biology, vol. 15, Nature Publishing Group, 2013, pp. 1405–14, doi:10.1038/ncb2869.
short: P. Campinho, M. Behrndt, J. Ranft, T. Risler, N. Minc, C.-P.J. Heisenberg,
Nature Cell Biology 15 (2013) 1405–1414.
date_created: 2018-12-11T11:56:45Z
date_published: 2013-11-10T00:00:00Z
date_updated: 2023-02-21T17:02:44Z
day: '10'
department:
- _id: CaHe
doi: 10.1038/ncb2869
intvolume: ' 15'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: http://hal.upmc.fr/hal-00983313/
month: '11'
oa: 1
oa_version: Submitted Version
page: 1405 - 1414
project:
- _id: 252ABD0A-B435-11E9-9278-68D0E5697425
call_identifier: FWF
grant_number: I 930-B20
name: Control of Epithelial Cell Layer Spreading in Zebrafish
publication: Nature Cell Biology
publication_status: published
publisher: Nature Publishing Group
publist_id: '4652'
quality_controlled: '1'
related_material:
record:
- id: '1403'
relation: dissertation_contains
status: public
scopus_import: 1
status: public
title: Tension-oriented cell divisions limit anisotropic tissue tension in epithelial
spreading during zebrafish epiboly
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 15
year: '2013'
...
---
_id: '2286'
abstract:
- lang: eng
text: The spatiotemporal control of cell divisions is a key factor in epithelial
morphogenesis and patterning. Mao et al (2013) now describe how differential rates
of proliferation within the Drosophila wing disc epithelium give rise to anisotropic
tissue tension in peripheral/proximal regions of the disc. Such global tissue
tension anisotropy in turn determines the orientation of cell divisions by controlling
epithelial cell elongation.
author:
- first_name: Pedro
full_name: Campinho, Pedro
id: 3AFBBC42-F248-11E8-B48F-1D18A9856A87
last_name: Campinho
orcid: 0000-0002-8526-5416
- first_name: Carl-Philipp J
full_name: Heisenberg, Carl-Philipp J
id: 39427864-F248-11E8-B48F-1D18A9856A87
last_name: Heisenberg
orcid: 0000-0002-0912-4566
citation:
ama: Campinho P, Heisenberg C-PJ. The force and effect of cell proliferation. EMBO
Journal. 2013;32(21):2783-2784. doi:10.1038/emboj.2013.225
apa: Campinho, P., & Heisenberg, C.-P. J. (2013). The force and effect of cell
proliferation. EMBO Journal. Wiley-Blackwell. https://doi.org/10.1038/emboj.2013.225
chicago: Campinho, Pedro, and Carl-Philipp J Heisenberg. “The Force and Effect of
Cell Proliferation.” EMBO Journal. Wiley-Blackwell, 2013. https://doi.org/10.1038/emboj.2013.225.
ieee: P. Campinho and C.-P. J. Heisenberg, “The force and effect of cell proliferation,”
EMBO Journal, vol. 32, no. 21. Wiley-Blackwell, pp. 2783–2784, 2013.
ista: Campinho P, Heisenberg C-PJ. 2013. The force and effect of cell proliferation.
EMBO Journal. 32(21), 2783–2784.
mla: Campinho, Pedro, and Carl-Philipp J. Heisenberg. “The Force and Effect of Cell
Proliferation.” EMBO Journal, vol. 32, no. 21, Wiley-Blackwell, 2013, pp.
2783–84, doi:10.1038/emboj.2013.225.
short: P. Campinho, C.-P.J. Heisenberg, EMBO Journal 32 (2013) 2783–2784.
date_created: 2018-12-11T11:56:46Z
date_published: 2013-10-04T00:00:00Z
date_updated: 2021-01-12T06:56:32Z
day: '04'
department:
- _id: CaHe
doi: 10.1038/emboj.2013.225
external_id:
pmid:
- '24097062'
intvolume: ' 32'
issue: '21'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3817470/
month: '10'
oa: 1
oa_version: Submitted Version
page: 2783 - 2784
pmid: 1
publication: EMBO Journal
publication_status: published
publisher: Wiley-Blackwell
publist_id: '4645'
quality_controlled: '1'
scopus_import: 1
status: public
title: The force and effect of cell proliferation
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 32
year: '2013'
...
---
_id: '1406'
abstract:
- lang: eng
text: Epithelial spreading is a critical part of various developmental and wound
repair processes. Here we use zebrafish epiboly as a model system to study the
cellular and molecular mechanisms underlying the spreading of epithelial sheets.
During zebrafish epiboly the enveloping cell layer (EVL), a simple squamous epithelium,
spreads over the embryo to eventually cover the entire yolk cell by the end of
gastrulation. The EVL leading edge is anchored through tight junctions to the
yolk syncytial layer (YSL), where directly adjacent to the EVL margin a contractile
actomyosin ring is formed that is thought to drive EVL epiboly. The prevalent
view in the field was that the contractile ring exerts a pulling force on the
EVL margin, which pulls the EVL towards the vegetal pole. However, how this force
is generated and how it affects EVL morphology still remains elusive. Moreover,
the cellular mechanisms mediating the increase in EVL surface area, while maintaining
tissue integrity and function are still unclear. Here we show that the YSL actomyosin
ring pulls on the EVL margin by two distinct force-generating mechanisms. One
mechanism is based on contraction of the ring around its circumference, as previously
proposed. The second mechanism is based on actomyosin retrogade flows, generating
force through resistance against the substrate. The latter can function at any
epiboly stage even in situations where the contraction-based mechanism is unproductive.
Additionally, we demonstrate that during epiboly the EVL is subjected to anisotropic
tension, which guides the orientation of EVL cell division along the main axis
(animal-vegetal) of tension. The influence of tension in cell division orientation
involves cell elongation and requires myosin-2 activity for proper spindle alignment.
Strikingly, we reveal that tension-oriented cell divisions release anisotropic
tension within the EVL and that in the absence of such divisions, EVL cells undergo
ectopic fusions. We conclude that forces applied to the EVL by the action of the
YSL actomyosin ring generate a tension anisotropy in the EVL that orients cell
divisions, which in turn limit tissue tension increase thereby facilitating tissue
spreading.
acknowledged_ssus:
- _id: Bio
- _id: PreCl
alternative_title:
- ISTA Thesis
article_processing_charge: No
author:
- first_name: Pedro
full_name: Campinho, Pedro
id: 3AFBBC42-F248-11E8-B48F-1D18A9856A87
last_name: Campinho
orcid: 0000-0002-8526-5416
citation:
ama: 'Campinho P. Mechanics of zebrafish epiboly: Tension-oriented cell divisions
limit anisotropic tissue tension in epithelial spreading. 2013.'
apa: 'Campinho, P. (2013). Mechanics of zebrafish epiboly: Tension-oriented cell
divisions limit anisotropic tissue tension in epithelial spreading. Institute
of Science and Technology Austria.'
chicago: 'Campinho, Pedro. “Mechanics of Zebrafish Epiboly: Tension-Oriented Cell
Divisions Limit Anisotropic Tissue Tension in Epithelial Spreading.” Institute
of Science and Technology Austria, 2013.'
ieee: 'P. Campinho, “Mechanics of zebrafish epiboly: Tension-oriented cell divisions
limit anisotropic tissue tension in epithelial spreading,” Institute of Science
and Technology Austria, 2013.'
ista: 'Campinho P. 2013. Mechanics of zebrafish epiboly: Tension-oriented cell divisions
limit anisotropic tissue tension in epithelial spreading. Institute of Science
and Technology Austria.'
mla: 'Campinho, Pedro. Mechanics of Zebrafish Epiboly: Tension-Oriented Cell
Divisions Limit Anisotropic Tissue Tension in Epithelial Spreading. Institute
of Science and Technology Austria, 2013.'
short: 'P. Campinho, Mechanics of Zebrafish Epiboly: Tension-Oriented Cell Divisions
Limit Anisotropic Tissue Tension in Epithelial Spreading, Institute of Science
and Technology Austria, 2013.'
date_created: 2018-12-11T11:51:50Z
date_published: 2013-10-01T00:00:00Z
date_updated: 2023-09-07T11:36:07Z
day: '01'
degree_awarded: PhD
department:
- _id: CaHe
language:
- iso: eng
month: '10'
oa_version: None
page: '123'
publication_identifier:
issn:
- 2663-337X
publication_status: published
publisher: Institute of Science and Technology Austria
publist_id: '5801'
status: public
supervisor:
- first_name: Carl-Philipp J
full_name: Heisenberg, Carl-Philipp J
id: 39427864-F248-11E8-B48F-1D18A9856A87
last_name: Heisenberg
orcid: 0000-0002-0912-4566
title: 'Mechanics of zebrafish epiboly: Tension-oriented cell divisions limit anisotropic
tissue tension in epithelial spreading'
type: dissertation
user_id: c635000d-4b10-11ee-a964-aac5a93f6ac1
year: '2013'
...
---
_id: '2950'
abstract:
- lang: eng
text: Contractile actomyosin rings drive various fundamental morphogenetic processes
ranging from cytokinesis to wound healing. Actomyosin rings are generally thought
to function by circumferential contraction. Here, we show that the spreading of
the enveloping cell layer (EVL) over the yolk cell during zebrafish gastrulation
is driven by a contractile actomyosin ring. In contrast to previous suggestions,
we find that this ring functions not only by circumferential contraction but also
by a flow-friction mechanism. This generates a pulling force through resistance
against retrograde actomyosin flow. EVL spreading proceeds normally in situations
where circumferential contraction is unproductive, indicating that the flow-friction
mechanism is sufficient. Thus, actomyosin rings can function in epithelial morphogenesis
through a combination of cable-constriction and flow-friction mechanisms.
acknowledged_ssus:
- _id: SSU
author:
- first_name: Martin
full_name: Behrndt, Martin
id: 3ECECA3A-F248-11E8-B48F-1D18A9856A87
last_name: Behrndt
- first_name: Guillaume
full_name: Salbreux, Guillaume
last_name: Salbreux
- first_name: Pedro
full_name: Campinho, Pedro
id: 3AFBBC42-F248-11E8-B48F-1D18A9856A87
last_name: Campinho
orcid: 0000-0002-8526-5416
- first_name: Robert
full_name: Hauschild, Robert
id: 4E01D6B4-F248-11E8-B48F-1D18A9856A87
last_name: Hauschild
orcid: 0000-0001-9843-3522
- first_name: Felix
full_name: Oswald, Felix
last_name: Oswald
- first_name: Julia
full_name: Roensch, Julia
id: 4220E59C-F248-11E8-B48F-1D18A9856A87
last_name: Roensch
- first_name: Stephan
full_name: Grill, Stephan
last_name: Grill
- first_name: Carl-Philipp J
full_name: Heisenberg, Carl-Philipp J
id: 39427864-F248-11E8-B48F-1D18A9856A87
last_name: Heisenberg
orcid: 0000-0002-0912-4566
citation:
ama: Behrndt M, Salbreux G, Campinho P, et al. Forces driving epithelial spreading
in zebrafish gastrulation. Science. 2012;338(6104):257-260. doi:10.1126/science.1224143
apa: Behrndt, M., Salbreux, G., Campinho, P., Hauschild, R., Oswald, F., Roensch,
J., … Heisenberg, C.-P. J. (2012). Forces driving epithelial spreading in zebrafish
gastrulation. Science. American Association for the Advancement of Science.
https://doi.org/10.1126/science.1224143
chicago: Behrndt, Martin, Guillaume Salbreux, Pedro Campinho, Robert Hauschild,
Felix Oswald, Julia Roensch, Stephan Grill, and Carl-Philipp J Heisenberg. “Forces
Driving Epithelial Spreading in Zebrafish Gastrulation.” Science. American
Association for the Advancement of Science, 2012. https://doi.org/10.1126/science.1224143.
ieee: M. Behrndt et al., “Forces driving epithelial spreading in zebrafish
gastrulation,” Science, vol. 338, no. 6104. American Association for the
Advancement of Science, pp. 257–260, 2012.
ista: Behrndt M, Salbreux G, Campinho P, Hauschild R, Oswald F, Roensch J, Grill
S, Heisenberg C-PJ. 2012. Forces driving epithelial spreading in zebrafish gastrulation.
Science. 338(6104), 257–260.
mla: Behrndt, Martin, et al. “Forces Driving Epithelial Spreading in Zebrafish Gastrulation.”
Science, vol. 338, no. 6104, American Association for the Advancement of
Science, 2012, pp. 257–60, doi:10.1126/science.1224143.
short: M. Behrndt, G. Salbreux, P. Campinho, R. Hauschild, F. Oswald, J. Roensch,
S. Grill, C.-P.J. Heisenberg, Science 338 (2012) 257–260.
date_created: 2018-12-11T12:00:30Z
date_published: 2012-10-12T00:00:00Z
date_updated: 2023-02-21T17:02:44Z
day: '12'
department:
- _id: CaHe
- _id: Bio
doi: 10.1126/science.1224143
intvolume: ' 338'
issue: '6104'
language:
- iso: eng
month: '10'
oa_version: None
page: 257 - 260
project:
- _id: 252ABD0A-B435-11E9-9278-68D0E5697425
call_identifier: FWF
grant_number: I 930-B20
name: Control of Epithelial Cell Layer Spreading in Zebrafish
publication: Science
publication_status: published
publisher: American Association for the Advancement of Science
publist_id: '3778'
quality_controlled: '1'
related_material:
record:
- id: '1403'
relation: dissertation_contains
status: public
scopus_import: 1
status: public
title: Forces driving epithelial spreading in zebrafish gastrulation
type: journal_article
user_id: 4435EBFC-F248-11E8-B48F-1D18A9856A87
volume: 338
year: '2012'
...
---
_id: '2951'
abstract:
- lang: eng
text: Differential cell adhesion and cortex tension are thought to drive cell sorting
by controlling cell-cell contact formation. Here, we show that cell adhesion and
cortex tension have different mechanical functions in controlling progenitor cell-cell
contact formation and sorting during zebrafish gastrulation. Cortex tension controls
cell-cell contact expansion by modulating interfacial tension at the contact.
By contrast, adhesion has little direct function in contact expansion, but instead
is needed to mechanically couple the cortices of adhering cells at their contacts,
allowing cortex tension to control contact expansion. The coupling function of
adhesion is mediated by E-cadherin and limited by the mechanical anchoring of
E-cadherin to the cortex. Thus, cell adhesion provides the mechanical scaffold
for cell cortex tension to drive cell sorting during gastrulation.
acknowledged_ssus:
- _id: SSU
author:
- first_name: Jean-Léon
full_name: Maître, Jean-Léon
id: 48F1E0D8-F248-11E8-B48F-1D18A9856A87
last_name: Maître
orcid: 0000-0002-3688-1474
- first_name: Hélène
full_name: Berthoumieux, Hélène
last_name: Berthoumieux
- first_name: Gabriel
full_name: Krens, Gabriel
id: 2B819732-F248-11E8-B48F-1D18A9856A87
last_name: Krens
orcid: 0000-0003-4761-5996
- first_name: Guillaume
full_name: Salbreux, Guillaume
last_name: Salbreux
- first_name: Frank
full_name: Julicher, Frank
last_name: Julicher
- first_name: Ewa
full_name: Paluch, Ewa
last_name: Paluch
- first_name: Carl-Philipp J
full_name: Heisenberg, Carl-Philipp J
id: 39427864-F248-11E8-B48F-1D18A9856A87
last_name: Heisenberg
orcid: 0000-0002-0912-4566
citation:
ama: Maître J-L, Berthoumieux H, Krens G, et al. Adhesion functions in cell sorting
by mechanically coupling the cortices of adhering cells. Science. 2012;338(6104):253-256.
doi:10.1126/science.1225399
apa: Maître, J.-L., Berthoumieux, H., Krens, G., Salbreux, G., Julicher, F., Paluch,
E., & Heisenberg, C.-P. J. (2012). Adhesion functions in cell sorting by mechanically
coupling the cortices of adhering cells. Science. American Association
for the Advancement of Science. https://doi.org/10.1126/science.1225399
chicago: Maître, Jean-Léon, Hélène Berthoumieux, Gabriel Krens, Guillaume Salbreux,
Frank Julicher, Ewa Paluch, and Carl-Philipp J Heisenberg. “Adhesion Functions
in Cell Sorting by Mechanically Coupling the Cortices of Adhering Cells.” Science.
American Association for the Advancement of Science, 2012. https://doi.org/10.1126/science.1225399.
ieee: J.-L. Maître et al., “Adhesion functions in cell sorting by mechanically
coupling the cortices of adhering cells,” Science, vol. 338, no. 6104.
American Association for the Advancement of Science, pp. 253–256, 2012.
ista: Maître J-L, Berthoumieux H, Krens G, Salbreux G, Julicher F, Paluch E, Heisenberg
C-PJ. 2012. Adhesion functions in cell sorting by mechanically coupling the cortices
of adhering cells. Science. 338(6104), 253–256.
mla: Maître, Jean-Léon, et al. “Adhesion Functions in Cell Sorting by Mechanically
Coupling the Cortices of Adhering Cells.” Science, vol. 338, no. 6104,
American Association for the Advancement of Science, 2012, pp. 253–56, doi:10.1126/science.1225399.
short: J.-L. Maître, H. Berthoumieux, G. Krens, G. Salbreux, F. Julicher, E. Paluch,
C.-P.J. Heisenberg, Science 338 (2012) 253–256.
date_created: 2018-12-11T12:00:31Z
date_published: 2012-10-12T00:00:00Z
date_updated: 2021-01-12T07:40:00Z
day: '12'
department:
- _id: CaHe
doi: 10.1126/science.1225399
intvolume: ' 338'
issue: '6104'
language:
- iso: eng
month: '10'
oa_version: None
page: 253 - 256
publication: Science
publication_status: published
publisher: American Association for the Advancement of Science
publist_id: '3777'
quality_controlled: '1'
scopus_import: 1
status: public
title: Adhesion functions in cell sorting by mechanically coupling the cortices of
adhering cells
type: journal_article
user_id: 4435EBFC-F248-11E8-B48F-1D18A9856A87
volume: 338
year: '2012'
...
---
_id: '2952'
abstract:
- lang: eng
text: Body axis elongation represents a common and fundamental morphogenetic process
in development. A key mechanism triggering body axis elongation without additional
growth is convergent extension (CE), whereby a tissue undergoes simultaneous narrowing
and extension. Both collective cell migration and cell intercalation are thought
to drive CE and are used to different degrees in various species as they elongate
their body axis. Here, we provide an overview of CE as a general strategy for
body axis elongation and discuss conserved and divergent mechanisms underlying
CE among different species.
acknowledgement: 'M.T. is supported by the UK Medical Research Council (MRC) and Royal
Society and C.-P.H. by the Fonds zur Förderung der wissenschaftlichen Forschung
(FWF), Deutsche Forschungsgemeinschaft (DFG) and Institute of Science and Technology
Austria. '
author:
- first_name: Masazumi
full_name: Tada, Masazumi
last_name: Tada
- first_name: Carl-Philipp J
full_name: Heisenberg, Carl-Philipp J
id: 39427864-F248-11E8-B48F-1D18A9856A87
last_name: Heisenberg
orcid: 0000-0002-0912-4566
citation:
ama: Tada M, Heisenberg C-PJ. Convergent extension Using collective cell migration
and cell intercalation to shape embryos. Development. 2012;139(21):3897-3904.
doi:10.1242/dev.073007
apa: Tada, M., & Heisenberg, C.-P. J. (2012). Convergent extension Using collective
cell migration and cell intercalation to shape embryos. Development. Company
of Biologists. https://doi.org/10.1242/dev.073007
chicago: Tada, Masazumi, and Carl-Philipp J Heisenberg. “Convergent Extension Using
Collective Cell Migration and Cell Intercalation to Shape Embryos.” Development.
Company of Biologists, 2012. https://doi.org/10.1242/dev.073007.
ieee: M. Tada and C.-P. J. Heisenberg, “Convergent extension Using collective cell
migration and cell intercalation to shape embryos,” Development, vol. 139,
no. 21. Company of Biologists, pp. 3897–3904, 2012.
ista: Tada M, Heisenberg C-PJ. 2012. Convergent extension Using collective cell
migration and cell intercalation to shape embryos. Development. 139(21), 3897–3904.
mla: Tada, Masazumi, and Carl-Philipp J. Heisenberg. “Convergent Extension Using
Collective Cell Migration and Cell Intercalation to Shape Embryos.” Development,
vol. 139, no. 21, Company of Biologists, 2012, pp. 3897–904, doi:10.1242/dev.073007.
short: M. Tada, C.-P.J. Heisenberg, Development 139 (2012) 3897–3904.
date_created: 2018-12-11T12:00:31Z
date_published: 2012-11-01T00:00:00Z
date_updated: 2021-01-12T07:40:00Z
day: '01'
department:
- _id: CaHe
doi: 10.1242/dev.073007
intvolume: ' 139'
issue: '21'
language:
- iso: eng
month: '11'
oa_version: None
page: 3897 - 3904
publication: Development
publication_status: published
publisher: Company of Biologists
publist_id: '3776'
quality_controlled: '1'
scopus_import: 1
status: public
title: Convergent extension Using collective cell migration and cell intercalation
to shape embryos
type: journal_article
user_id: 3E5EF7F0-F248-11E8-B48F-1D18A9856A87
volume: 139
year: '2012'
...
---
_id: '2953'
author:
- first_name: Carl-Philipp J
full_name: Heisenberg, Carl-Philipp J
id: 39427864-F248-11E8-B48F-1D18A9856A87
last_name: Heisenberg
orcid: 0000-0002-0912-4566
- first_name: Reinhard
full_name: Fässler, Reinhard
last_name: Fässler
citation:
ama: Heisenberg C-PJ, Fässler R. Cell-cell adhesion and extracellular matrix diversity
counts. Current Opinion in Cell Biology. 2012;24(5):559-561. doi:10.1016/j.ceb.2012.09.002
apa: Heisenberg, C.-P. J., & Fässler, R. (2012). Cell-cell adhesion and extracellular
matrix diversity counts. Current Opinion in Cell Biology. Elsevier. https://doi.org/10.1016/j.ceb.2012.09.002
chicago: Heisenberg, Carl-Philipp J, and Reinhard Fässler. “Cell-Cell Adhesion and
Extracellular Matrix Diversity Counts.” Current Opinion in Cell Biology.
Elsevier, 2012. https://doi.org/10.1016/j.ceb.2012.09.002.
ieee: C.-P. J. Heisenberg and R. Fässler, “Cell-cell adhesion and extracellular
matrix diversity counts,” Current Opinion in Cell Biology, vol. 24, no.
5. Elsevier, pp. 559–561, 2012.
ista: Heisenberg C-PJ, Fässler R. 2012. Cell-cell adhesion and extracellular matrix
diversity counts. Current Opinion in Cell Biology. 24(5), 559–561.
mla: Heisenberg, Carl-Philipp J., and Reinhard Fässler. “Cell-Cell Adhesion and
Extracellular Matrix Diversity Counts.” Current Opinion in Cell Biology,
vol. 24, no. 5, Elsevier, 2012, pp. 559–61, doi:10.1016/j.ceb.2012.09.002.
short: C.-P.J. Heisenberg, R. Fässler, Current Opinion in Cell Biology 24 (2012)
559–561.
date_created: 2018-12-11T12:00:31Z
date_published: 2012-10-01T00:00:00Z
date_updated: 2021-01-12T07:40:01Z
day: '01'
department:
- _id: CaHe
doi: 10.1016/j.ceb.2012.09.002
intvolume: ' 24'
issue: '5'
language:
- iso: eng
month: '10'
oa_version: None
page: 559 - 561
publication: Current Opinion in Cell Biology
publication_status: published
publisher: Elsevier
publist_id: '3773'
quality_controlled: '1'
scopus_import: 1
status: public
title: Cell-cell adhesion and extracellular matrix diversity counts
type: journal_article
user_id: 3E5EF7F0-F248-11E8-B48F-1D18A9856A87
volume: 24
year: '2012'
...
---
_id: '3245'
abstract:
- lang: eng
text: How cells orchestrate their behavior during collective migration is a long-standing
question. Using magnetic tweezers to apply mechanical stimuli to Xenopus mesendoderm
cells, Weber etal. (2012) now reveal, in this issue of Developmental Cell, a cadherin-mediated
mechanosensitive response that promotes cell polarization and movement persistence
during the collective mesendoderm migration in gastrulation.
author:
- first_name: Martin
full_name: Behrndt, Martin
id: 3ECECA3A-F248-11E8-B48F-1D18A9856A87
last_name: Behrndt
- first_name: Carl-Philipp J
full_name: Heisenberg, Carl-Philipp J
id: 39427864-F248-11E8-B48F-1D18A9856A87
last_name: Heisenberg
orcid: 0000-0002-0912-4566
citation:
ama: Behrndt M, Heisenberg C-PJ. Spurred by resistance mechanosensation in collective
migration. Developmental Cell. 2012;22(1):3-4. doi:10.1016/j.devcel.2011.12.018
apa: Behrndt, M., & Heisenberg, C.-P. J. (2012). Spurred by resistance mechanosensation
in collective migration. Developmental Cell. Cell Press. https://doi.org/10.1016/j.devcel.2011.12.018
chicago: Behrndt, Martin, and Carl-Philipp J Heisenberg. “Spurred by Resistance
Mechanosensation in Collective Migration.” Developmental Cell. Cell Press,
2012. https://doi.org/10.1016/j.devcel.2011.12.018.
ieee: M. Behrndt and C.-P. J. Heisenberg, “Spurred by resistance mechanosensation
in collective migration,” Developmental Cell, vol. 22, no. 1. Cell Press,
pp. 3–4, 2012.
ista: Behrndt M, Heisenberg C-PJ. 2012. Spurred by resistance mechanosensation in
collective migration. Developmental Cell. 22(1), 3–4.
mla: Behrndt, Martin, and Carl-Philipp J. Heisenberg. “Spurred by Resistance Mechanosensation
in Collective Migration.” Developmental Cell, vol. 22, no. 1, Cell Press,
2012, pp. 3–4, doi:10.1016/j.devcel.2011.12.018.
short: M. Behrndt, C.-P.J. Heisenberg, Developmental Cell 22 (2012) 3–4.
date_created: 2018-12-11T12:02:14Z
date_published: 2012-01-17T00:00:00Z
date_updated: 2021-01-12T07:42:05Z
day: '17'
department:
- _id: CaHe
doi: 10.1016/j.devcel.2011.12.018
intvolume: ' 22'
issue: '1'
language:
- iso: eng
month: '01'
oa_version: None
page: 3 - 4
publication: Developmental Cell
publication_status: published
publisher: Cell Press
publist_id: '3426'
quality_controlled: '1'
scopus_import: 1
status: public
title: Spurred by resistance mechanosensation in collective migration
type: journal_article
user_id: 3E5EF7F0-F248-11E8-B48F-1D18A9856A87
volume: 22
year: '2012'
...
---
_id: '3246'
abstract:
- lang: eng
text: Visualizing and analyzing shape changes at various scales, ranging from single
molecules to whole organisms, are essential for understanding complex morphogenetic
processes, such as early embryonic development. Embryo morphogenesis relies on
the interplay between different tissues, the properties of which are again determined
by the interaction between their constituent cells. Cell interactions, on the
other hand, are controlled by various molecules, such as signaling and adhesion
molecules, which in order to exert their functions need to be spatiotemporally
organized within and between the interacting cells. In this review, we will focus
on the role of cell adhesion functioning at different scales to organize cell,
tissue and embryo morphogenesis. We will specifically ask how the subcellular
distribution of adhesion molecules controls the formation of cell-cell contacts,
how cell-cell contacts determine tissue shape, and how tissue interactions regulate
embryo morphogenesis.
acknowledgement: This review comes from a themed issue on Cell structure and dynamics
Edited by Jason Swedlow and Gaudenz Danuser
author:
- first_name: Vanessa
full_name: Barone, Vanessa
id: 419EECCC-F248-11E8-B48F-1D18A9856A87
last_name: Barone
orcid: 0000-0003-2676-3367
- first_name: Carl-Philipp J
full_name: Heisenberg, Carl-Philipp J
id: 39427864-F248-11E8-B48F-1D18A9856A87
last_name: Heisenberg
orcid: 0000-0002-0912-4566
citation:
ama: Barone V, Heisenberg C-PJ. Cell adhesion in embryo morphogenesis. Current
Opinion in Cell Biology. 2012;24(1):148-153. doi:10.1016/j.ceb.2011.11.006
apa: Barone, V., & Heisenberg, C.-P. J. (2012). Cell adhesion in embryo morphogenesis.
Current Opinion in Cell Biology. Elsevier. https://doi.org/10.1016/j.ceb.2011.11.006
chicago: Barone, Vanessa, and Carl-Philipp J Heisenberg. “Cell Adhesion in Embryo
Morphogenesis.” Current Opinion in Cell Biology. Elsevier, 2012. https://doi.org/10.1016/j.ceb.2011.11.006.
ieee: V. Barone and C.-P. J. Heisenberg, “Cell adhesion in embryo morphogenesis,”
Current Opinion in Cell Biology, vol. 24, no. 1. Elsevier, pp. 148–153,
2012.
ista: Barone V, Heisenberg C-PJ. 2012. Cell adhesion in embryo morphogenesis. Current
Opinion in Cell Biology. 24(1), 148–153.
mla: Barone, Vanessa, and Carl-Philipp J. Heisenberg. “Cell Adhesion in Embryo Morphogenesis.”
Current Opinion in Cell Biology, vol. 24, no. 1, Elsevier, 2012, pp. 148–53,
doi:10.1016/j.ceb.2011.11.006.
short: V. Barone, C.-P.J. Heisenberg, Current Opinion in Cell Biology 24 (2012)
148–153.
date_created: 2018-12-11T12:02:14Z
date_published: 2012-02-01T00:00:00Z
date_updated: 2023-09-07T12:05:08Z
day: '01'
department:
- _id: CaHe
doi: 10.1016/j.ceb.2011.11.006
intvolume: ' 24'
issue: '1'
language:
- iso: eng
month: '02'
oa_version: None
page: 148 - 153
publication: Current Opinion in Cell Biology
publication_status: published
publisher: Elsevier
publist_id: '3423'
quality_controlled: '1'
related_material:
record:
- id: '961'
relation: dissertation_contains
status: public
scopus_import: 1
status: public
title: Cell adhesion in embryo morphogenesis
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 24
year: '2012'
...
---
_id: '3273'
alternative_title:
- ISTA Thesis
article_processing_charge: No
author:
- first_name: Jean-Léon
full_name: Maître, Jean-Léon
id: 48F1E0D8-F248-11E8-B48F-1D18A9856A87
last_name: Maître
orcid: 0000-0002-3688-1474
citation:
ama: Maître J-L. Mechanics of adhesion and de‐adhesion in zebrafish germ layer progenitors.
2011.
apa: Maître, J.-L. (2011). Mechanics of adhesion and de‐adhesion in zebrafish
germ layer progenitors. Institute of Science and Technology Austria.
chicago: Maître, Jean-Léon. “Mechanics of Adhesion and De‐adhesion in Zebrafish
Germ Layer Progenitors.” Institute of Science and Technology Austria, 2011.
ieee: J.-L. Maître, “Mechanics of adhesion and de‐adhesion in zebrafish germ layer
progenitors,” Institute of Science and Technology Austria, 2011.
ista: Maître J-L. 2011. Mechanics of adhesion and de‐adhesion in zebrafish germ
layer progenitors. Institute of Science and Technology Austria.
mla: Maître, Jean-Léon. Mechanics of Adhesion and De‐adhesion in Zebrafish Germ
Layer Progenitors. Institute of Science and Technology Austria, 2011.
short: J.-L. Maître, Mechanics of Adhesion and De‐adhesion in Zebrafish Germ Layer
Progenitors, Institute of Science and Technology Austria, 2011.
date_created: 2018-12-11T12:02:23Z
date_published: 2011-12-12T00:00:00Z
date_updated: 2023-09-07T11:30:16Z
day: '12'
degree_awarded: PhD
department:
- _id: CaHe
language:
- iso: eng
month: '12'
oa_version: None
publication_identifier:
issn:
- 2663-337X
publication_status: published
publisher: Institute of Science and Technology Austria
publist_id: '3373'
status: public
supervisor:
- first_name: Carl-Philipp J
full_name: Heisenberg, Carl-Philipp J
id: 39427864-F248-11E8-B48F-1D18A9856A87
last_name: Heisenberg
orcid: 0000-0002-0912-4566
title: Mechanics of adhesion and de‐adhesion in zebrafish germ layer progenitors
type: dissertation
user_id: c635000d-4b10-11ee-a964-aac5a93f6ac1
year: '2011'
...
---
_id: '3287'
abstract:
- lang: eng
text: 'Diffusing membrane constituents are constantly exposed to a variety of forces
that influence their stochastic path. Single molecule experiments allow for resolving
trajectories at extremely high spatial and temporal accuracy, thereby offering
insights into en route interactions of the tracer. In this review we discuss approaches
to derive information about the underlying processes, based on single molecule
tracking experiments. In particular, we focus on a new versatile way to analyze
single molecule diffusion in the absence of a full analytical treatment. The method
is based on comprehensive comparison of an experimental data set against the hypothetical
outcome of multiple experiments performed on the computer. Since Monte Carlo simulations
can be easily and rapidly performed even on state-of-the-art PCs, our method provides
a simple way for testing various - even complicated - diffusion models. We describe
the new method in detail, and show the applicability on two specific examples:
firstly, kinetic rate constants can be derived for the transient interaction of
mobile membrane proteins; secondly, residence time and corral size can be extracted
for confined diffusion.'
author:
- first_name: Verena
full_name: Ruprecht, Verena
id: 4D71A03A-F248-11E8-B48F-1D18A9856A87
last_name: Ruprecht
orcid: 0000-0003-4088-8633
- first_name: Markus
full_name: Axmann, Markus
last_name: Axmann
- first_name: Stefan
full_name: Wieser, Stefan
id: 355AA5A0-F248-11E8-B48F-1D18A9856A87
last_name: Wieser
orcid: 0000-0002-2670-2217
- first_name: Gerhard
full_name: Schuetz, Gerhard
last_name: Schuetz
citation:
ama: Ruprecht V, Axmann M, Wieser S, Schuetz G. What can we learn from single molecule
trajectories? Current Protein & Peptide Science. 2011;12(8):714-724.
doi:10.2174/138920311798841753
apa: Ruprecht, V., Axmann, M., Wieser, S., & Schuetz, G. (2011). What can we
learn from single molecule trajectories? Current Protein & Peptide Science.
Bentham Science Publishers. https://doi.org/10.2174/138920311798841753
chicago: Ruprecht, Verena, Markus Axmann, Stefan Wieser, and Gerhard Schuetz. “What
Can We Learn from Single Molecule Trajectories?” Current Protein & Peptide
Science. Bentham Science Publishers, 2011. https://doi.org/10.2174/138920311798841753.
ieee: V. Ruprecht, M. Axmann, S. Wieser, and G. Schuetz, “What can we learn from
single molecule trajectories?,” Current Protein & Peptide Science,
vol. 12, no. 8. Bentham Science Publishers, pp. 714–724, 2011.
ista: Ruprecht V, Axmann M, Wieser S, Schuetz G. 2011. What can we learn from single
molecule trajectories? Current Protein & Peptide Science. 12(8), 714–724.
mla: Ruprecht, Verena, et al. “What Can We Learn from Single Molecule Trajectories?”
Current Protein & Peptide Science, vol. 12, no. 8, Bentham Science
Publishers, 2011, pp. 714–24, doi:10.2174/138920311798841753.
short: V. Ruprecht, M. Axmann, S. Wieser, G. Schuetz, Current Protein & Peptide
Science 12 (2011) 714–724.
date_created: 2018-12-11T12:02:28Z
date_published: 2011-12-01T00:00:00Z
date_updated: 2021-01-12T07:42:24Z
day: '01'
department:
- _id: CaHe
- _id: MiSi
doi: 10.2174/138920311798841753
intvolume: ' 12'
issue: '8'
language:
- iso: eng
month: '12'
oa_version: None
page: 714 - 724
publication: Current Protein & Peptide Science
publication_status: published
publisher: Bentham Science Publishers
publist_id: '3358'
quality_controlled: '1'
scopus_import: 1
status: public
title: What can we learn from single molecule trajectories?
type: journal_article
user_id: 4435EBFC-F248-11E8-B48F-1D18A9856A87
volume: 12
year: '2011'
...
---
_id: '3288'
abstract:
- lang: eng
text: 'The zonula adherens (ZA) of epithelial cells is a site of cell-cell adhesion
where cellular forces are exerted and resisted. Increasing evidence indicates
that E-cadherin adhesion molecules at the ZA serve to sense force applied on the
junctions and coordinate cytoskeletal responses to those forces. Efforts to understand
the role that cadherins play in mechanotransduction have been limited by the lack
of assays to measure the impact of forces on the ZA. In this study we used 4D
imaging of GFP-tagged E-cadherin to analyse the movement of the ZA. Junctions
in confluent epithelial monolayers displayed prominent movements oriented orthogonal
(perpendicular) to the ZA itself. Two components were identified in these movements:
a relatively slow unidirectional (translational) component that could be readily
fitted by least-squares regression analysis, upon which were superimposed more
rapid oscillatory movements. Myosin IIB was a dominant factor responsible for
driving the unilateral translational movements. In contrast, frequency spectrum
analysis revealed that depletion of Myosin IIA increased the power of the oscillatory
movements. This implies that Myosin IIA may serve to dampen oscillatory movements
of the ZA. This extends our recent analysis of Myosin II at the ZA to demonstrate
that Myosin IIA and Myosin IIB make distinct contributions to junctional movement
at the ZA.'
acknowledgement: his work was funded by the National Health and Medical Research Council
(NHMRC) of Australia. M.S. was an Erwin Schroedinger postdoctoral fellow of the
Austrian Science Fund (FWF), S.K.W. is supported by a UQ International Research
Tuition Award and Research Scholarship, S.M .by an ANZ Trustees PhD Scholarship.
A.S.Y. is a Research Fellow of the NHMRC. Confocal imaging was performed at the
Australian Cancer Research Foundation (ACRF) Cancer Biology Imaging Centre at the
Institute for Molecular Bioscience, established with the generous support of the
ACRF.
author:
- first_name: Michael
full_name: Smutny, Michael
id: 3FE6E4E8-F248-11E8-B48F-1D18A9856A87
last_name: Smutny
orcid: 0000-0002-5920-9090
- first_name: Selwin
full_name: Wu, Selwin
last_name: Wu
- first_name: Guillermo
full_name: Gomez, Guillermo
last_name: Gomez
- first_name: Sabine
full_name: Mangold, Sabine
last_name: Mangold
- first_name: Alpha
full_name: Yap, Alpha
last_name: Yap
- first_name: Nicholas
full_name: Hamilton, Nicholas
last_name: Hamilton
citation:
ama: Smutny M, Wu S, Gomez G, Mangold S, Yap A, Hamilton N. Multicomponent analysis
of junctional movements regulated by Myosin II isoforms at the epithelial zonula
adherens. PLoS One. 2011;6(7). doi:10.1371/journal.pone.0022458
apa: Smutny, M., Wu, S., Gomez, G., Mangold, S., Yap, A., & Hamilton, N. (2011).
Multicomponent analysis of junctional movements regulated by Myosin II isoforms
at the epithelial zonula adherens. PLoS One. Public Library of Science.
https://doi.org/10.1371/journal.pone.0022458
chicago: Smutny, Michael, Selwin Wu, Guillermo Gomez, Sabine Mangold, Alpha Yap,
and Nicholas Hamilton. “Multicomponent Analysis of Junctional Movements Regulated
by Myosin II Isoforms at the Epithelial Zonula Adherens.” PLoS One. Public
Library of Science, 2011. https://doi.org/10.1371/journal.pone.0022458.
ieee: M. Smutny, S. Wu, G. Gomez, S. Mangold, A. Yap, and N. Hamilton, “Multicomponent
analysis of junctional movements regulated by Myosin II isoforms at the epithelial
zonula adherens,” PLoS One, vol. 6, no. 7. Public Library of Science, 2011.
ista: Smutny M, Wu S, Gomez G, Mangold S, Yap A, Hamilton N. 2011. Multicomponent
analysis of junctional movements regulated by Myosin II isoforms at the epithelial
zonula adherens. PLoS One. 6(7).
mla: Smutny, Michael, et al. “Multicomponent Analysis of Junctional Movements Regulated
by Myosin II Isoforms at the Epithelial Zonula Adherens.” PLoS One, vol.
6, no. 7, Public Library of Science, 2011, doi:10.1371/journal.pone.0022458.
short: M. Smutny, S. Wu, G. Gomez, S. Mangold, A. Yap, N. Hamilton, PLoS One 6 (2011).
date_created: 2018-12-11T12:02:28Z
date_published: 2011-07-22T00:00:00Z
date_updated: 2021-01-12T07:42:25Z
day: '22'
ddc:
- '570'
department:
- _id: CaHe
doi: 10.1371/journal.pone.0022458
file:
- access_level: open_access
checksum: 57a5eb11dd05241c48c44f492b3ec3ac
content_type: application/pdf
creator: dernst
date_created: 2019-05-10T10:51:43Z
date_updated: 2020-07-14T12:46:06Z
file_id: '6399'
file_name: 2011_PLOS_Smutny.PDF
file_size: 1984567
relation: main_file
file_date_updated: 2020-07-14T12:46:06Z
has_accepted_license: '1'
intvolume: ' 6'
issue: '7'
language:
- iso: eng
license: https://creativecommons.org/licenses/by/4.0/
month: '07'
oa: 1
oa_version: Published Version
publication: PLoS One
publication_status: published
publisher: Public Library of Science
publist_id: '3357'
quality_controlled: '1'
status: public
title: Multicomponent analysis of junctional movements regulated by Myosin II isoforms
at the epithelial zonula adherens
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 6
year: '2011'
...
---
_id: '3368'
abstract:
- lang: eng
text: Tissue surface tension (TST) is an important mechanical property influencing
cell sorting and tissue envelopment. The study by Manning et al. (1) reported
on a mathematical model describing TST on the basis of the balance between adhesive
and tensile properties of the constituent cells. The model predicts that, in high-adhesion
cell aggregates, surface cells will be stretched to maintain the same area of
cell–cell contact as interior bulk cells, resulting in an elongated and flattened
cell shape. The authors (1) observed flat and elongated cells at the surface of
high-adhesion zebrafish germ-layer explants, which they argue are undifferentiated
stretched germ-layer progenitor cells, and they use this observation as a validation
of their model.
author:
- first_name: Gabriel
full_name: Krens, Gabriel
id: 2B819732-F248-11E8-B48F-1D18A9856A87
last_name: Krens
orcid: 0000-0003-4761-5996
- first_name: Stephanie
full_name: Möllmert, Stephanie
id: 260FD49C-E911-11E9-B5EA-D9538404589B
last_name: Möllmert
- first_name: Carl-Philipp J
full_name: Heisenberg, Carl-Philipp J
id: 39427864-F248-11E8-B48F-1D18A9856A87
last_name: Heisenberg
orcid: 0000-0002-0912-4566
citation:
ama: Krens G, Möllmert S, Heisenberg C-PJ. Enveloping cell layer differentiation
at the surface of zebrafish germ layer tissue explants. PNAS. 2011;108(3):E9-E10.
doi:10.1073/pnas.1010767108
apa: Krens, G., Möllmert, S., & Heisenberg, C.-P. J. (2011). Enveloping cell
layer differentiation at the surface of zebrafish germ layer tissue explants.
PNAS. National Academy of Sciences. https://doi.org/10.1073/pnas.1010767108
chicago: Krens, Gabriel, Stephanie Möllmert, and Carl-Philipp J Heisenberg. “Enveloping
Cell Layer Differentiation at the Surface of Zebrafish Germ Layer Tissue Explants.”
PNAS. National Academy of Sciences, 2011. https://doi.org/10.1073/pnas.1010767108.
ieee: G. Krens, S. Möllmert, and C.-P. J. Heisenberg, “Enveloping cell layer differentiation
at the surface of zebrafish germ layer tissue explants,” PNAS, vol. 108,
no. 3. National Academy of Sciences, pp. E9–E10, 2011.
ista: Krens G, Möllmert S, Heisenberg C-PJ. 2011. Enveloping cell layer differentiation
at the surface of zebrafish germ layer tissue explants. PNAS. 108(3), E9–E10.
mla: Krens, Gabriel, et al. “Enveloping Cell Layer Differentiation at the Surface
of Zebrafish Germ Layer Tissue Explants.” PNAS, vol. 108, no. 3, National
Academy of Sciences, 2011, pp. E9–10, doi:10.1073/pnas.1010767108.
short: G. Krens, S. Möllmert, C.-P.J. Heisenberg, PNAS 108 (2011) E9–E10.
date_created: 2018-12-11T12:02:56Z
date_published: 2011-01-18T00:00:00Z
date_updated: 2021-01-12T07:43:00Z
day: '18'
department:
- _id: CaHe
doi: 10.1073/pnas.1010767108
external_id:
pmid:
- '21212360'
intvolume: ' 108'
issue: '3'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3024655
month: '01'
oa: 1
oa_version: Submitted Version
page: E9 - E10
pmid: 1
publication: PNAS
publication_status: published
publisher: National Academy of Sciences
publist_id: '3244'
quality_controlled: '1'
scopus_import: 1
status: public
title: Enveloping cell layer differentiation at the surface of zebrafish germ layer
tissue explants
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 108
year: '2011'
...
---
_id: '3373'
abstract:
- lang: eng
text: The use of optical traps to measure or apply forces on the molecular level
requires a precise knowledge of the trapping force field. Close to the trap center,
this field is typically approximated as linear in the displacement of the trapped
microsphere. However, applications demanding high forces at low laser intensities
can probe the light-microsphere interaction beyond the linear regime. Here, we
measured the full nonlinear force and displacement response of an optical trap
in two dimensions using a dual-beam optical trap setup with back-focal-plane photodetection.
We observed a substantial stiffening of the trap beyond the linear regime that
depends on microsphere size, in agreement with Mie theory calculations. Surprisingly,
we found that the linear detection range for forces exceeds the one for displacement
by far. Our approach allows for a complete calibration of an optical trap.
article_processing_charge: No
author:
- first_name: Marcus
full_name: Jahnel, Marcus
last_name: Jahnel
- first_name: Martin
full_name: Behrndt, Martin
id: 3ECECA3A-F248-11E8-B48F-1D18A9856A87
last_name: Behrndt
- first_name: Anita
full_name: Jannasch, Anita
last_name: Jannasch
- first_name: Erik
full_name: Schaeffer, Erik
last_name: Schaeffer
- first_name: Stephan
full_name: Grill, Stephan
last_name: Grill
citation:
ama: Jahnel M, Behrndt M, Jannasch A, Schaeffer E, Grill S. Measuring the complete
force field of an optical trap. Optics Letters. 2011;36(7):1260-1262. doi:10.1364/OL.36.001260
apa: Jahnel, M., Behrndt, M., Jannasch, A., Schaeffer, E., & Grill, S. (2011).
Measuring the complete force field of an optical trap. Optics Letters.
Optica Publishing Group. https://doi.org/10.1364/OL.36.001260
chicago: Jahnel, Marcus, Martin Behrndt, Anita Jannasch, Erik Schaeffer, and Stephan
Grill. “Measuring the Complete Force Field of an Optical Trap.” Optics Letters.
Optica Publishing Group, 2011. https://doi.org/10.1364/OL.36.001260.
ieee: M. Jahnel, M. Behrndt, A. Jannasch, E. Schaeffer, and S. Grill, “Measuring
the complete force field of an optical trap,” Optics Letters, vol. 36,
no. 7. Optica Publishing Group, pp. 1260–1262, 2011.
ista: Jahnel M, Behrndt M, Jannasch A, Schaeffer E, Grill S. 2011. Measuring the
complete force field of an optical trap. Optics Letters. 36(7), 1260–1262.
mla: Jahnel, Marcus, et al. “Measuring the Complete Force Field of an Optical Trap.”
Optics Letters, vol. 36, no. 7, Optica Publishing Group, 2011, pp. 1260–62,
doi:10.1364/OL.36.001260.
short: M. Jahnel, M. Behrndt, A. Jannasch, E. Schaeffer, S. Grill, Optics Letters
36 (2011) 1260–1262.
date_created: 2018-12-11T12:02:58Z
date_published: 2011-03-30T00:00:00Z
date_updated: 2023-10-17T12:16:58Z
day: '30'
department:
- _id: CaHe
doi: 10.1364/OL.36.001260
intvolume: ' 36'
issue: '7'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://www.osapublishing.org/ol/abstract.cfm?uri=ol-36-7-1260
month: '03'
oa: 1
oa_version: Published Version
page: 1260 - 1262
publication: Optics Letters
publication_status: published
publisher: Optica Publishing Group
publist_id: '3234'
quality_controlled: '1'
related_material:
record:
- id: '1403'
relation: dissertation_contains
status: public
scopus_import: '1'
status: public
title: Measuring the complete force field of an optical trap
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 36
year: '2011'
...
---
_id: '3379'
abstract:
- lang: eng
text: The process of gastrulation is highly conserved across vertebrates on both
the genetic and morphological levels, despite great variety in embryonic shape
and speed of development. This mechanism spatially separates the germ layers and
establishes the organizational foundation for future development. Mesodermal identity
is specified in a superficial layer of cells, the epiblast, where cells maintain
an epithelioid morphology. These cells involute to join the deeper hypoblast layer
where they adopt a migratory, mesenchymal morphology. Expression of a cascade
of related transcription factors orchestrates the parallel genetic transition
from primitive to mature mesoderm. Although the early and late stages of this
process are increasingly well understood, the transition between them has remained
largely mysterious. We present here the first high resolution in vivo observations
of the blebby transitional morphology of involuting mesodermal cells in a vertebrate
embryo. We further demonstrate that the zebrafish spadetail mutation creates a
reversible block in the maturation program, stalling cells in the transition state.
This mutation creates an ideal system for dissecting the specific properties of
cells undergoing the morphological transition of maturing mesoderm, as we demonstrate
with a direct measurement of cell–cell adhesion.
article_type: original
author:
- first_name: Richard
full_name: Row, Richard
last_name: Row
- first_name: Jean-Léon
full_name: Maître, Jean-Léon
id: 48F1E0D8-F248-11E8-B48F-1D18A9856A87
last_name: Maître
orcid: 0000-0002-3688-1474
- first_name: Benjamin
full_name: Martin, Benjamin
last_name: Martin
- first_name: Petra
full_name: Stockinger, Petra
id: 261CB030-E90D-11E9-B182-F697D44B663C
last_name: Stockinger
- first_name: Carl-Philipp J
full_name: Heisenberg, Carl-Philipp J
id: 39427864-F248-11E8-B48F-1D18A9856A87
last_name: Heisenberg
orcid: 0000-0002-0912-4566
- first_name: David
full_name: Kimelman, David
last_name: Kimelman
citation:
ama: Row R, Maître J-L, Martin B, Stockinger P, Heisenberg C-PJ, Kimelman D. Completion
of the epithelial to mesenchymal transition in zebrafish mesoderm requires Spadetail.
Developmental Biology. 2011;354(1):102-110. doi:10.1016/j.ydbio.2011.03.025
apa: Row, R., Maître, J.-L., Martin, B., Stockinger, P., Heisenberg, C.-P. J., &
Kimelman, D. (2011). Completion of the epithelial to mesenchymal transition in
zebrafish mesoderm requires Spadetail. Developmental Biology. Elsevier.
https://doi.org/10.1016/j.ydbio.2011.03.025
chicago: Row, Richard, Jean-Léon Maître, Benjamin Martin, Petra Stockinger, Carl-Philipp
J Heisenberg, and David Kimelman. “Completion of the Epithelial to Mesenchymal
Transition in Zebrafish Mesoderm Requires Spadetail.” Developmental Biology.
Elsevier, 2011. https://doi.org/10.1016/j.ydbio.2011.03.025.
ieee: R. Row, J.-L. Maître, B. Martin, P. Stockinger, C.-P. J. Heisenberg, and D.
Kimelman, “Completion of the epithelial to mesenchymal transition in zebrafish
mesoderm requires Spadetail,” Developmental Biology, vol. 354, no. 1. Elsevier,
pp. 102–110, 2011.
ista: Row R, Maître J-L, Martin B, Stockinger P, Heisenberg C-PJ, Kimelman D. 2011.
Completion of the epithelial to mesenchymal transition in zebrafish mesoderm requires
Spadetail. Developmental Biology. 354(1), 102–110.
mla: Row, Richard, et al. “Completion of the Epithelial to Mesenchymal Transition
in Zebrafish Mesoderm Requires Spadetail.” Developmental Biology, vol.
354, no. 1, Elsevier, 2011, pp. 102–10, doi:10.1016/j.ydbio.2011.03.025.
short: R. Row, J.-L. Maître, B. Martin, P. Stockinger, C.-P.J. Heisenberg, D. Kimelman,
Developmental Biology 354 (2011) 102–110.
date_created: 2018-12-11T12:03:00Z
date_published: 2011-06-01T00:00:00Z
date_updated: 2021-01-12T07:43:04Z
day: '01'
department:
- _id: CaHe
doi: 10.1016/j.ydbio.2011.03.025
external_id:
pmid:
- '1463614'
intvolume: ' 354'
issue: '1'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3090540/
month: '06'
oa: 1
oa_version: Submitted Version
page: 102 - 110
pmid: 1
publication: Developmental Biology
publication_status: published
publisher: Elsevier
publist_id: '3228'
quality_controlled: '1'
scopus_import: 1
status: public
title: Completion of the epithelial to mesenchymal transition in zebrafish mesoderm
requires Spadetail
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 354
year: '2011'
...
---
_id: '3383'
author:
- first_name: Carl-Philipp J
full_name: Heisenberg, Carl-Philipp J
id: 39427864-F248-11E8-B48F-1D18A9856A87
last_name: Heisenberg
orcid: 0000-0002-0912-4566
citation:
ama: Heisenberg C-PJ. Invited Lectures ‐ Symposia Area. FEBS Journal. 2011;278(S1):24-24.
doi:10.1111/j.1742-4658.2011.08136.x
apa: Heisenberg, C.-P. J. (2011). Invited Lectures ‐ Symposia Area. FEBS Journal.
Wiley-Blackwell. https://doi.org/10.1111/j.1742-4658.2011.08136.x
chicago: Heisenberg, Carl-Philipp J. “Invited Lectures ‐ Symposia Area.” FEBS
Journal. Wiley-Blackwell, 2011. https://doi.org/10.1111/j.1742-4658.2011.08136.x.
ieee: C.-P. J. Heisenberg, “Invited Lectures ‐ Symposia Area,” FEBS Journal,
vol. 278, no. S1. Wiley-Blackwell, pp. 24–24, 2011.
ista: Heisenberg C-PJ. 2011. Invited Lectures ‐ Symposia Area. FEBS Journal. 278(S1),
24–24.
mla: Heisenberg, Carl-Philipp J. “Invited Lectures ‐ Symposia Area.” FEBS Journal,
vol. 278, no. S1, Wiley-Blackwell, 2011, pp. 24–24, doi:10.1111/j.1742-4658.2011.08136.x.
short: C.-P.J. Heisenberg, FEBS Journal 278 (2011) 24–24.
date_created: 2018-12-11T12:03:01Z
date_published: 2011-07-01T00:00:00Z
date_updated: 2021-01-12T07:43:06Z
day: '01'
department:
- _id: CaHe
doi: 10.1111/j.1742-4658.2011.08136.x
intvolume: ' 278'
issue: S1
language:
- iso: eng
month: '07'
oa_version: None
page: 24 - 24
publication: FEBS Journal
publication_status: published
publisher: Wiley-Blackwell
publist_id: '3224'
status: public
title: Invited Lectures ‐ Symposia Area
type: journal_article
user_id: 4435EBFC-F248-11E8-B48F-1D18A9856A87
volume: 278
year: '2011'
...
---
_id: '3396'
abstract:
- lang: eng
text: Facial branchiomotor neurons (FBMNs) in zebrafish and mouse embryonic hindbrain
undergo a characteristic tangential migration from rhombomere (r) 4, where they
are born, to r6/7. Cohesion among neuroepithelial cells (NCs) has been suggested
to function in FBMN migration by inhibiting FBMNs positioned in the basal neuroepithelium
such that they move apically between NCs towards the midline of the neuroepithelium
instead of tangentially along the basal side of the neuroepithelium towards r6/7.
However, direct experimental evaluation of this hypothesis is still lacking. Here,
we have used a combination of biophysical cell adhesion measurements and high-resolution
time-lapse microscopy to determine the role of NC cohesion in FBMN migration.
We show that reducing NC cohesion by interfering with Cadherin 2 (Cdh2) activity
results in FBMNs positioned at the basal side of the neuroepithelium moving apically
towards the neural tube midline instead of tangentially towards r6/7. In embryos
with strongly reduced NC cohesion, ectopic apical FBMN movement frequently results
in fusion of the bilateral FBMN clusters over the apical midline of the neural
tube. By contrast, reducing cohesion among FBMNs by interfering with Contactin
2 (Cntn2) expression in these cells has little effect on apical FBMN movement,
but reduces the fusion of the bilateral FBMN clusters in embryos with strongly
diminished NC cohesion. These data provide direct experimental evidence that NC
cohesion functions in tangential FBMN migration by restricting their apical movement.
acknowledged_ssus:
- _id: Bio
- _id: PreCl
article_type: original
author:
- first_name: Petra
full_name: Stockinger, Petra
id: 261CB030-E90D-11E9-B182-F697D44B663C
last_name: Stockinger
- first_name: Carl-Philipp J
full_name: Heisenberg, Carl-Philipp J
id: 39427864-F248-11E8-B48F-1D18A9856A87
last_name: Heisenberg
orcid: 0000-0002-0912-4566
- first_name: Jean-Léon
full_name: Maître, Jean-Léon
id: 48F1E0D8-F248-11E8-B48F-1D18A9856A87
last_name: Maître
orcid: 0000-0002-3688-1474
citation:
ama: Stockinger P, Heisenberg C-PJ, Maître J-L. Defective neuroepithelial cell cohesion
affects tangential branchiomotor neuron migration in the zebrafish neural tube.
Development. 2011;138(21):4673-4683. doi:10.1242/dev.071233
apa: Stockinger, P., Heisenberg, C.-P. J., & Maître, J.-L. (2011). Defective
neuroepithelial cell cohesion affects tangential branchiomotor neuron migration
in the zebrafish neural tube. Development. Company of Biologists. https://doi.org/10.1242/dev.071233
chicago: Stockinger, Petra, Carl-Philipp J Heisenberg, and Jean-Léon Maître. “Defective
Neuroepithelial Cell Cohesion Affects Tangential Branchiomotor Neuron Migration
in the Zebrafish Neural Tube.” Development. Company of Biologists, 2011.
https://doi.org/10.1242/dev.071233.
ieee: P. Stockinger, C.-P. J. Heisenberg, and J.-L. Maître, “Defective neuroepithelial
cell cohesion affects tangential branchiomotor neuron migration in the zebrafish
neural tube,” Development, vol. 138, no. 21. Company of Biologists, pp.
4673–4683, 2011.
ista: Stockinger P, Heisenberg C-PJ, Maître J-L. 2011. Defective neuroepithelial
cell cohesion affects tangential branchiomotor neuron migration in the zebrafish
neural tube. Development. 138(21), 4673–4683.
mla: Stockinger, Petra, et al. “Defective Neuroepithelial Cell Cohesion Affects
Tangential Branchiomotor Neuron Migration in the Zebrafish Neural Tube.” Development,
vol. 138, no. 21, Company of Biologists, 2011, pp. 4673–83, doi:10.1242/dev.071233.
short: P. Stockinger, C.-P.J. Heisenberg, J.-L. Maître, Development 138 (2011) 4673–4683.
date_created: 2018-12-11T12:03:06Z
date_published: 2011-09-28T00:00:00Z
date_updated: 2021-01-12T07:43:11Z
day: '28'
ddc:
- '570'
department:
- _id: CaHe
doi: 10.1242/dev.071233
file:
- access_level: open_access
checksum: ca12b79e01ef36c1ef1aea31cf7e7139
content_type: application/pdf
creator: dernst
date_created: 2019-10-07T14:19:42Z
date_updated: 2020-07-14T12:46:12Z
file_id: '6930'
file_name: 2011_Development_Stockinger.pdf
file_size: 4672439
relation: main_file
file_date_updated: 2020-07-14T12:46:12Z
has_accepted_license: '1'
intvolume: ' 138'
issue: '21'
language:
- iso: eng
month: '09'
oa: 1
oa_version: Published Version
page: 4673 - 4683
publication: Development
publication_status: published
publisher: Company of Biologists
publist_id: '3210'
quality_controlled: '1'
scopus_import: 1
status: public
title: Defective neuroepithelial cell cohesion affects tangential branchiomotor neuron
migration in the zebrafish neural tube
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 138
year: '2011'
...
---
_id: '3397'
abstract:
- lang: eng
text: Recent advances in microscopy techniques and biophysical measurements have
provided novel insight into the molecular, cellular and biophysical basis of cell
adhesion. However, comparably little is known about a core element of cell–cell
adhesion—the energy of adhesion at the cell–cell contact. In this review, we discuss
approaches to understand the nature and regulation of adhesion energy, and propose
strategies to determine adhesion energy between cells in vitro and in vivo.
author:
- first_name: Jean-Léon
full_name: Maître, Jean-Léon
id: 48F1E0D8-F248-11E8-B48F-1D18A9856A87
last_name: Maître
orcid: 0000-0002-3688-1474
- first_name: Carl-Philipp J
full_name: Heisenberg, Carl-Philipp J
id: 39427864-F248-11E8-B48F-1D18A9856A87
last_name: Heisenberg
orcid: 0000-0002-0912-4566
citation:
ama: Maître J-L, Heisenberg C-PJ. The role of adhesion energy in controlling cell-cell
contacts. Current Opinion in Cell Biology. 2011;23(5):508-514. doi:10.1016/j.ceb.2011.07.004
apa: Maître, J.-L., & Heisenberg, C.-P. J. (2011). The role of adhesion energy
in controlling cell-cell contacts. Current Opinion in Cell Biology. Elsevier.
https://doi.org/10.1016/j.ceb.2011.07.004
chicago: Maître, Jean-Léon, and Carl-Philipp J Heisenberg. “The Role of Adhesion
Energy in Controlling Cell-Cell Contacts.” Current Opinion in Cell Biology.
Elsevier, 2011. https://doi.org/10.1016/j.ceb.2011.07.004.
ieee: J.-L. Maître and C.-P. J. Heisenberg, “The role of adhesion energy in controlling
cell-cell contacts,” Current Opinion in Cell Biology, vol. 23, no. 5. Elsevier,
pp. 508–514, 2011.
ista: Maître J-L, Heisenberg C-PJ. 2011. The role of adhesion energy in controlling
cell-cell contacts. Current Opinion in Cell Biology. 23(5), 508–514.
mla: Maître, Jean-Léon, and Carl-Philipp J. Heisenberg. “The Role of Adhesion Energy
in Controlling Cell-Cell Contacts.” Current Opinion in Cell Biology, vol.
23, no. 5, Elsevier, 2011, pp. 508–14, doi:10.1016/j.ceb.2011.07.004.
short: J.-L. Maître, C.-P.J. Heisenberg, Current Opinion in Cell Biology 23 (2011)
508–514.
date_created: 2018-12-11T12:03:06Z
date_published: 2011-10-01T00:00:00Z
date_updated: 2021-01-12T07:43:12Z
day: '01'
department:
- _id: CaHe
doi: 10.1016/j.ceb.2011.07.004
intvolume: ' 23'
issue: '5'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3188705/
month: '10'
oa: 1
oa_version: Submitted Version
page: 508 - 514
publication: Current Opinion in Cell Biology
publication_status: published
publisher: Elsevier
publist_id: '3211'
quality_controlled: '1'
scopus_import: 1
status: public
title: The role of adhesion energy in controlling cell-cell contacts
type: journal_article
user_id: 4435EBFC-F248-11E8-B48F-1D18A9856A87
volume: 23
year: '2011'
...