---
_id: '2022'
abstract:
- lang: eng
  text: Radial glial progenitors (RGPs) are responsible for producing nearly all neocortical
    neurons. To gain insight into the patterns of RGP division and neuron production,
    we quantitatively analyzed excitatory neuron genesis in the mouse neocortex using
    Mosaic Analysis with Double Markers, which provides single-cell resolution of
    progenitor division patterns and potential in vivo. We found that RGPs progress
    through a coherent program in which their proliferative potential diminishes in
    a predictable manner. Upon entry into the neurogenic phase, individual RGPs produce
    ∼8–9 neurons distributed in both deep and superficial layers, indicating a unitary
    output in neuronal production. Removal of OTX1, a transcription factor transiently
    expressed in RGPs, results in both deep- and superficial-layer neuron loss and
    a reduction in neuronal unit size. Moreover, ∼1/6 of neurogenic RGPs proceed to
    produce glia. These results suggest that progenitor behavior and histogenesis
    in the mammalian neocortex conform to a remarkably orderly and deterministic program.
author:
- first_name: Peng
  full_name: Gao, Peng
  last_name: Gao
- first_name: Maria P
  full_name: Postiglione, Maria P
  id: 2C67902A-F248-11E8-B48F-1D18A9856A87
  last_name: Postiglione
- first_name: Teresa
  full_name: Krieger, Teresa
  last_name: Krieger
- first_name: Luisirene
  full_name: Hernandez, Luisirene
  last_name: Hernandez
- first_name: Chao
  full_name: Wang, Chao
  last_name: Wang
- first_name: Zhi
  full_name: Han, Zhi
  last_name: Han
- first_name: Carmen
  full_name: Streicher, Carmen
  id: 36BCB99C-F248-11E8-B48F-1D18A9856A87
  last_name: Streicher
- first_name: Ekaterina
  full_name: Papusheva, Ekaterina
  id: 41DB591E-F248-11E8-B48F-1D18A9856A87
  last_name: Papusheva
- first_name: Ryan
  full_name: Insolera, Ryan
  last_name: Insolera
- first_name: Kritika
  full_name: Chugh, Kritika
  last_name: Chugh
- first_name: Oren
  full_name: Kodish, Oren
  last_name: Kodish
- first_name: Kun
  full_name: Huang, Kun
  last_name: Huang
- first_name: Benjamin
  full_name: Simons, Benjamin
  last_name: Simons
- first_name: Liqun
  full_name: Luo, Liqun
  last_name: Luo
- first_name: Simon
  full_name: Hippenmeyer, Simon
  id: 37B36620-F248-11E8-B48F-1D18A9856A87
  last_name: Hippenmeyer
  orcid: 0000-0003-2279-1061
- first_name: Song
  full_name: Shi, Song
  last_name: Shi
citation:
  ama: Gao P, Postiglione MP, Krieger T, et al. Deterministic progenitor behavior
    and unitary production of neurons in the neocortex. <i>Cell</i>. 2014;159(4):775-788.
    doi:<a href="https://doi.org/10.1016/j.cell.2014.10.027">10.1016/j.cell.2014.10.027</a>
  apa: Gao, P., Postiglione, M. P., Krieger, T., Hernandez, L., Wang, C., Han, Z.,
    … Shi, S. (2014). Deterministic progenitor behavior and unitary production of
    neurons in the neocortex. <i>Cell</i>. Cell Press. <a href="https://doi.org/10.1016/j.cell.2014.10.027">https://doi.org/10.1016/j.cell.2014.10.027</a>
  chicago: Gao, Peng, Maria P Postiglione, Teresa Krieger, Luisirene Hernandez, Chao
    Wang, Zhi Han, Carmen Streicher, et al. “Deterministic Progenitor Behavior and
    Unitary Production of Neurons in the Neocortex.” <i>Cell</i>. Cell Press, 2014.
    <a href="https://doi.org/10.1016/j.cell.2014.10.027">https://doi.org/10.1016/j.cell.2014.10.027</a>.
  ieee: P. Gao <i>et al.</i>, “Deterministic progenitor behavior and unitary production
    of neurons in the neocortex,” <i>Cell</i>, vol. 159, no. 4. Cell Press, pp. 775–788,
    2014.
  ista: Gao P, Postiglione MP, Krieger T, Hernandez L, Wang C, Han Z, Streicher C,
    Papusheva E, Insolera R, Chugh K, Kodish O, Huang K, Simons B, Luo L, Hippenmeyer
    S, Shi S. 2014. Deterministic progenitor behavior and unitary production of neurons
    in the neocortex. Cell. 159(4), 775–788.
  mla: Gao, Peng, et al. “Deterministic Progenitor Behavior and Unitary Production
    of Neurons in the Neocortex.” <i>Cell</i>, vol. 159, no. 4, Cell Press, 2014,
    pp. 775–88, doi:<a href="https://doi.org/10.1016/j.cell.2014.10.027">10.1016/j.cell.2014.10.027</a>.
  short: P. Gao, M.P. Postiglione, T. Krieger, L. Hernandez, C. Wang, Z. Han, C. Streicher,
    E. Papusheva, R. Insolera, K. Chugh, O. Kodish, K. Huang, B. Simons, L. Luo, S.
    Hippenmeyer, S. Shi, Cell 159 (2014) 775–788.
date_created: 2018-12-11T11:55:16Z
date_published: 2014-11-06T00:00:00Z
date_updated: 2021-01-12T06:54:47Z
day: '06'
ddc:
- '570'
department:
- _id: SiHi
- _id: Bio
doi: 10.1016/j.cell.2014.10.027
ec_funded: 1
file:
- access_level: open_access
  checksum: 6c5de8329bb2ffa71cba9fda750f14ce
  content_type: application/pdf
  creator: system
  date_created: 2018-12-12T10:08:47Z
  date_updated: 2020-07-14T12:45:25Z
  file_id: '4709'
  file_name: IST-2016-423-v1+1_1-s2.0-S0092867414013154-main.pdf
  file_size: 4435787
  relation: main_file
file_date_updated: 2020-07-14T12:45:25Z
has_accepted_license: '1'
intvolume: '       159'
issue: '4'
language:
- iso: eng
month: '11'
oa: 1
oa_version: Published Version
page: 775 - 788
project:
- _id: 25D61E48-B435-11E9-9278-68D0E5697425
  call_identifier: FP7
  grant_number: '618444'
  name: Molecular Mechanisms of Cerebral Cortex Development
- _id: 25D7962E-B435-11E9-9278-68D0E5697425
  grant_number: RGP0053/2014
  name: Quantitative Structure-Function Analysis of Cerebral Cortex Assembly at Clonal
    Level
publication: Cell
publication_status: published
publisher: Cell Press
publist_id: '5050'
pubrep_id: '423'
quality_controlled: '1'
scopus_import: 1
status: public
title: Deterministic progenitor behavior and unitary production of neurons in the
  neocortex
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: 4435EBFC-F248-11E8-B48F-1D18A9856A87
volume: 159
year: '2014'
...
---
_id: '2839'
abstract:
- lang: eng
  text: Directional guidance of cells via gradients of chemokines is considered crucial
    for embryonic development, cancer dissemination, and immune responses. Nevertheless,
    the concept still lacks direct experimental confirmation in vivo. Here, we identify
    endogenous gradients of the chemokine CCL21 within mouse skin and show that they
    guide dendritic cells toward lymphatic vessels. Quantitative imaging reveals depots
    of CCL21 within lymphatic endothelial cells and steeply decaying gradients within
    the perilymphatic interstitium. These gradients match the migratory patterns of
    the dendritic cells, which directionally approach vessels from a distance of up
    to 90-micrometers. Interstitial CCL21 is immobilized to heparan sulfates, and
    its experimental delocalization or swamping the endogenous gradients abolishes
    directed migration. These findings functionally establish the concept of haptotaxis,
    directed migration along immobilized gradients, in tissues.
acknowledgement: We thank M. Frank for technical assistance and S. Cremer, P. Schmalhorst,
  and E. Kiermaier for critical reading of the manuscript. This work was supported
  by a Humboldt Foundation postdoctoral fellowship (to M.W.), the German Research
  Foundation (Si1323 1,2 to M.S.), the Human Frontier Science Program (HFSP RGP0058/2011
  to M.S.), the European Research Council (ERC StG 281556 to M.S.), and the Swiss
  National Science Foundation (31003A 127474 to D.F.L., 130488 to S.A.L.).
article_processing_charge: No
article_type: original
author:
- first_name: Michele
  full_name: Weber, Michele
  id: 3A3FC708-F248-11E8-B48F-1D18A9856A87
  last_name: Weber
- first_name: Robert
  full_name: Hauschild, Robert
  id: 4E01D6B4-F248-11E8-B48F-1D18A9856A87
  last_name: Hauschild
  orcid: 0000-0001-9843-3522
- first_name: Jan
  full_name: Schwarz, Jan
  id: 346C1EC6-F248-11E8-B48F-1D18A9856A87
  last_name: Schwarz
- first_name: Christine
  full_name: Moussion, Christine
  id: 3356F664-F248-11E8-B48F-1D18A9856A87
  last_name: Moussion
- first_name: Ingrid
  full_name: De Vries, Ingrid
  id: 4C7D837E-F248-11E8-B48F-1D18A9856A87
  last_name: De Vries
- first_name: Daniel
  full_name: Legler, Daniel
  last_name: Legler
- first_name: Sanjiv
  full_name: Luther, Sanjiv
  last_name: Luther
- first_name: Mark Tobias
  full_name: Bollenbach, Mark Tobias
  id: 3E6DB97A-F248-11E8-B48F-1D18A9856A87
  last_name: Bollenbach
  orcid: 0000-0003-4398-476X
- first_name: Michael K
  full_name: Sixt, Michael K
  id: 41E9FBEA-F248-11E8-B48F-1D18A9856A87
  last_name: Sixt
  orcid: 0000-0002-6620-9179
citation:
  ama: Weber M, Hauschild R, Schwarz J, et al. Interstitial dendritic cell guidance
    by haptotactic chemokine gradients. <i>Science</i>. 2013;339(6117):328-332. doi:<a
    href="https://doi.org/10.1126/science.1228456">10.1126/science.1228456</a>
  apa: Weber, M., Hauschild, R., Schwarz, J., Moussion, C., de Vries, I., Legler,
    D., … Sixt, M. K. (2013). Interstitial dendritic cell guidance by haptotactic
    chemokine gradients. <i>Science</i>. American Association for the Advancement
    of Science. <a href="https://doi.org/10.1126/science.1228456">https://doi.org/10.1126/science.1228456</a>
  chicago: Weber, Michele, Robert Hauschild, Jan Schwarz, Christine Moussion, Ingrid
    de Vries, Daniel Legler, Sanjiv Luther, Mark Tobias Bollenbach, and Michael K
    Sixt. “Interstitial Dendritic Cell Guidance by Haptotactic Chemokine Gradients.”
    <i>Science</i>. American Association for the Advancement of Science, 2013. <a
    href="https://doi.org/10.1126/science.1228456">https://doi.org/10.1126/science.1228456</a>.
  ieee: M. Weber <i>et al.</i>, “Interstitial dendritic cell guidance by haptotactic
    chemokine gradients,” <i>Science</i>, vol. 339, no. 6117. American Association
    for the Advancement of Science, pp. 328–332, 2013.
  ista: Weber M, Hauschild R, Schwarz J, Moussion C, de Vries I, Legler D, Luther
    S, Bollenbach MT, Sixt MK. 2013. Interstitial dendritic cell guidance by haptotactic
    chemokine gradients. Science. 339(6117), 328–332.
  mla: Weber, Michele, et al. “Interstitial Dendritic Cell Guidance by Haptotactic
    Chemokine Gradients.” <i>Science</i>, vol. 339, no. 6117, American Association
    for the Advancement of Science, 2013, pp. 328–32, doi:<a href="https://doi.org/10.1126/science.1228456">10.1126/science.1228456</a>.
  short: M. Weber, R. Hauschild, J. Schwarz, C. Moussion, I. de Vries, D. Legler,
    S. Luther, M.T. Bollenbach, M.K. Sixt, Science 339 (2013) 328–332.
date_created: 2018-12-11T11:59:52Z
date_published: 2013-01-18T00:00:00Z
date_updated: 2022-06-10T10:21:40Z
day: '18'
department:
- _id: MiSi
- _id: Bio
doi: 10.1126/science.1228456
ec_funded: 1
intvolume: '       339'
issue: '6117'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://kops.uni-konstanz.de/bitstream/123456789/26341/2/Weber_263418.pdf
month: '01'
oa: 1
oa_version: Published Version
page: 328 - 332
project:
- _id: 25A603A2-B435-11E9-9278-68D0E5697425
  call_identifier: FP7
  grant_number: '281556'
  name: Cytoskeletal force generation and force transduction of migrating leukocytes
    (EU)
- _id: 25ABD200-B435-11E9-9278-68D0E5697425
  grant_number: RGP0058/2011
  name: 'Cell migration in complex environments: from in vivo experiments to theoretical
    models'
publication: Science
publication_status: published
publisher: American Association for the Advancement of Science
publist_id: '3959'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Interstitial dendritic cell guidance by haptotactic chemokine gradients
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 339
year: '2013'
...
---
_id: '2950'
abstract:
- lang: eng
  text: Contractile actomyosin rings drive various fundamental morphogenetic processes
    ranging from cytokinesis to wound healing. Actomyosin rings are generally thought
    to function by circumferential contraction. Here, we show that the spreading of
    the enveloping cell layer (EVL) over the yolk cell during zebrafish gastrulation
    is driven by a contractile actomyosin ring. In contrast to previous suggestions,
    we find that this ring functions not only by circumferential contraction but also
    by a flow-friction mechanism. This generates a pulling force through resistance
    against retrograde actomyosin flow. EVL spreading proceeds normally in situations
    where circumferential contraction is unproductive, indicating that the flow-friction
    mechanism is sufficient. Thus, actomyosin rings can function in epithelial morphogenesis
    through a combination of cable-constriction and flow-friction mechanisms.
acknowledged_ssus:
- _id: SSU
author:
- first_name: Martin
  full_name: Behrndt, Martin
  id: 3ECECA3A-F248-11E8-B48F-1D18A9856A87
  last_name: Behrndt
- first_name: Guillaume
  full_name: Salbreux, Guillaume
  last_name: Salbreux
- first_name: Pedro
  full_name: Campinho, Pedro
  id: 3AFBBC42-F248-11E8-B48F-1D18A9856A87
  last_name: Campinho
  orcid: 0000-0002-8526-5416
- first_name: Robert
  full_name: Hauschild, Robert
  id: 4E01D6B4-F248-11E8-B48F-1D18A9856A87
  last_name: Hauschild
  orcid: 0000-0001-9843-3522
- first_name: Felix
  full_name: Oswald, Felix
  last_name: Oswald
- first_name: Julia
  full_name: Roensch, Julia
  id: 4220E59C-F248-11E8-B48F-1D18A9856A87
  last_name: Roensch
- first_name: Stephan
  full_name: Grill, Stephan
  last_name: Grill
- first_name: Carl-Philipp J
  full_name: Heisenberg, Carl-Philipp J
  id: 39427864-F248-11E8-B48F-1D18A9856A87
  last_name: Heisenberg
  orcid: 0000-0002-0912-4566
citation:
  ama: Behrndt M, Salbreux G, Campinho P, et al. Forces driving epithelial spreading
    in zebrafish gastrulation. <i>Science</i>. 2012;338(6104):257-260. doi:<a href="https://doi.org/10.1126/science.1224143">10.1126/science.1224143</a>
  apa: Behrndt, M., Salbreux, G., Campinho, P., Hauschild, R., Oswald, F., Roensch,
    J., … Heisenberg, C.-P. J. (2012). Forces driving epithelial spreading in zebrafish
    gastrulation. <i>Science</i>. American Association for the Advancement of Science.
    <a href="https://doi.org/10.1126/science.1224143">https://doi.org/10.1126/science.1224143</a>
  chicago: Behrndt, Martin, Guillaume Salbreux, Pedro Campinho, Robert Hauschild,
    Felix Oswald, Julia Roensch, Stephan Grill, and Carl-Philipp J Heisenberg. “Forces
    Driving Epithelial Spreading in Zebrafish Gastrulation.” <i>Science</i>. American
    Association for the Advancement of Science, 2012. <a href="https://doi.org/10.1126/science.1224143">https://doi.org/10.1126/science.1224143</a>.
  ieee: M. Behrndt <i>et al.</i>, “Forces driving epithelial spreading in zebrafish
    gastrulation,” <i>Science</i>, vol. 338, no. 6104. American Association for the
    Advancement of Science, pp. 257–260, 2012.
  ista: Behrndt M, Salbreux G, Campinho P, Hauschild R, Oswald F, Roensch J, Grill
    S, Heisenberg C-PJ. 2012. Forces driving epithelial spreading in zebrafish gastrulation.
    Science. 338(6104), 257–260.
  mla: Behrndt, Martin, et al. “Forces Driving Epithelial Spreading in Zebrafish Gastrulation.”
    <i>Science</i>, vol. 338, no. 6104, American Association for the Advancement of
    Science, 2012, pp. 257–60, doi:<a href="https://doi.org/10.1126/science.1224143">10.1126/science.1224143</a>.
  short: M. Behrndt, G. Salbreux, P. Campinho, R. Hauschild, F. Oswald, J. Roensch,
    S. Grill, C.-P.J. Heisenberg, Science 338 (2012) 257–260.
date_created: 2018-12-11T12:00:30Z
date_published: 2012-10-12T00:00:00Z
date_updated: 2023-02-21T17:02:44Z
day: '12'
department:
- _id: CaHe
- _id: Bio
doi: 10.1126/science.1224143
intvolume: '       338'
issue: '6104'
language:
- iso: eng
month: '10'
oa_version: None
page: 257 - 260
project:
- _id: 252ABD0A-B435-11E9-9278-68D0E5697425
  call_identifier: FWF
  grant_number: I 930-B20
  name: Control of Epithelial Cell Layer Spreading in Zebrafish
publication: Science
publication_status: published
publisher: American Association for the Advancement of Science
publist_id: '3778'
quality_controlled: '1'
related_material:
  record:
  - id: '1403'
    relation: dissertation_contains
    status: public
scopus_import: 1
status: public
title: Forces driving epithelial spreading in zebrafish gastrulation
type: journal_article
user_id: 4435EBFC-F248-11E8-B48F-1D18A9856A87
volume: 338
year: '2012'
...
---
_id: '9943'
abstract:
- lang: eng
  text: Segmentation is the process of partitioning digital images into meaningful
    regions. The analysis of biological high content images often requires segmentation
    as a first step. We propose ilastik as an easy-to-use tool which allows the user
    without expertise in image processing to perform segmentation and classification
    in a unified way. ilastik learns from labels provided by the user through a convenient
    mouse interface. Based on these labels, ilastik infers a problem specific segmentation.
    A random forest classifier is used in the learning step, in which each pixel's
    neighborhood is characterized by a set of generic (nonlinear) features. ilastik
    supports up to three spatial plus one spectral dimension and makes use of all
    dimensions in the feature calculation. ilastik provides realtime feedback that
    enables the user to interactively refine the segmentation result and hence further
    fine-tune the classifier. An uncertainty measure guides the user to ambiguous
    regions in the images. Real time performance is achieved by multi-threading which
    fully exploits the capabilities of modern multi-core machines. Once a classifier
    has been trained on a set of representative images, it can be exported and used
    to automatically process a very large number of images (e.g. using the CellProfiler
    pipeline). ilastik is an open source project and released under the BSD license
    at www.ilastik.org.
article_processing_charge: No
author:
- first_name: Christoph M
  full_name: Sommer, Christoph M
  id: 4DF26D8C-F248-11E8-B48F-1D18A9856A87
  last_name: Sommer
  orcid: 0000-0003-1216-9105
- first_name: Christoph
  full_name: Straehle, Christoph
  last_name: Straehle
- first_name: Ullrich
  full_name: Köthe, Ullrich
  last_name: Köthe
- first_name: Fred A.
  full_name: Hamprecht, Fred A.
  last_name: Hamprecht
citation:
  ama: 'Sommer CM, Straehle C, Köthe U, Hamprecht FA. Ilastik: Interactive learning
    and segmentation toolkit. In: <i>2011 IEEE International Symposium on Biomedical
    Imaging: From Nano to Micro</i>. Institute of Electrical and Electronics Engineers;
    2011. doi:<a href="https://doi.org/10.1109/isbi.2011.5872394">10.1109/isbi.2011.5872394</a>'
  apa: 'Sommer, C. M., Straehle, C., Köthe, U., &#38; Hamprecht, F. A. (2011). Ilastik:
    Interactive learning and segmentation toolkit. In <i>2011 IEEE International Symposium
    on Biomedical Imaging: from Nano to Micro</i>. Chicago, Illinois, USA: Institute
    of Electrical and Electronics Engineers. <a href="https://doi.org/10.1109/isbi.2011.5872394">https://doi.org/10.1109/isbi.2011.5872394</a>'
  chicago: 'Sommer, Christoph M, Christoph Straehle, Ullrich Köthe, and Fred A. Hamprecht.
    “Ilastik: Interactive Learning and Segmentation Toolkit.” In <i>2011 IEEE International
    Symposium on Biomedical Imaging: From Nano to Micro</i>. Institute of Electrical
    and Electronics Engineers, 2011. <a href="https://doi.org/10.1109/isbi.2011.5872394">https://doi.org/10.1109/isbi.2011.5872394</a>.'
  ieee: 'C. M. Sommer, C. Straehle, U. Köthe, and F. A. Hamprecht, “Ilastik: Interactive
    learning and segmentation toolkit,” in <i>2011 IEEE International Symposium on
    Biomedical Imaging: from Nano to Micro</i>, Chicago, Illinois, USA, 2011.'
  ista: 'Sommer CM, Straehle C, Köthe U, Hamprecht FA. 2011. Ilastik: Interactive
    learning and segmentation toolkit. 2011 IEEE International Symposium on Biomedical
    Imaging: from Nano to Micro. ISBI: International Symposium on Biomedical Imaging.'
  mla: 'Sommer, Christoph M., et al. “Ilastik: Interactive Learning and Segmentation
    Toolkit.” <i>2011 IEEE International Symposium on Biomedical Imaging: From Nano
    to Micro</i>, Institute of Electrical and Electronics Engineers, 2011, doi:<a
    href="https://doi.org/10.1109/isbi.2011.5872394">10.1109/isbi.2011.5872394</a>.'
  short: 'C.M. Sommer, C. Straehle, U. Köthe, F.A. Hamprecht, in:, 2011 IEEE International
    Symposium on Biomedical Imaging: From Nano to Micro, Institute of Electrical and
    Electronics Engineers, 2011.'
conference:
  end_date: 2011-04-02
  location: Chicago, Illinois, USA
  name: 'ISBI: International Symposium on Biomedical Imaging'
  start_date: 2011-03-30
date_created: 2021-08-19T11:49:58Z
date_published: 2011-06-09T00:00:00Z
date_updated: 2023-02-23T14:13:38Z
day: '09'
department:
- _id: Bio
doi: 10.1109/isbi.2011.5872394
extern: '1'
keyword:
- image segmentation
- biomedical imaging
- three dimensional displays
- neurons
- retina
- observers
- image color analysis
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://www.researchgate.net/publication/224241106_Ilastik_Interactive_learning_and_segmentation_toolkit
month: '06'
oa: 1
oa_version: Preprint
publication: '2011 IEEE International Symposium on Biomedical Imaging: from Nano to
  Micro'
publication_identifier:
  eissn:
  - 1945-8452
  isbn:
  - 978-1-4244-4127-3
  issn:
  - 1945-7928
publication_status: published
publisher: Institute of Electrical and Electronics Engineers
quality_controlled: '1'
status: public
title: 'Ilastik: Interactive learning and segmentation toolkit'
type: conference
user_id: 8b945eb4-e2f2-11eb-945a-df72226e66a9
year: '2011'
...
---
_id: '4157'
abstract:
- lang: eng
  text: Integrin- and cadherin-mediated adhesion is central for cell and tissue morphogenesis,
    allowing cells and tissues to change shape without loosing integrity. Studies
    predominantly in cell culture showed that mechanosensation through adhesion structures
    is achieved by force-mediated modulation of their molecular composition. The specific
    molecular composition of adhesion sites in turn determines their signalling activity
    and dynamic reorganization. Here, we will review how adhesion sites respond to
    mecanical stimuli, and how spatially and temporally regulated signalling from
    different adhesion sites controls cell migration and tissue morphogenesis.
acknowledged_ssus:
- _id: Bio
author:
- first_name: Ekaterina
  full_name: Papusheva, Ekaterina
  id: 41DB591E-F248-11E8-B48F-1D18A9856A87
  last_name: Papusheva
- first_name: Carl-Philipp J
  full_name: Heisenberg, Carl-Philipp J
  id: 39427864-F248-11E8-B48F-1D18A9856A87
  last_name: Heisenberg
  orcid: 0000-0002-0912-4566
citation:
  ama: 'Papusheva E, Heisenberg C-PJ. Spatial organization of adhesion: force-dependent
    regulation and function in tissue morphogenesis. <i>EMBO Journal</i>. 2010;29(16):2753-2768.
    doi:<a href="https://doi.org/10.1038/emboj.2010.182">10.1038/emboj.2010.182</a>'
  apa: 'Papusheva, E., &#38; Heisenberg, C.-P. J. (2010). Spatial organization of
    adhesion: force-dependent regulation and function in tissue morphogenesis. <i>EMBO
    Journal</i>. Wiley-Blackwell. <a href="https://doi.org/10.1038/emboj.2010.182">https://doi.org/10.1038/emboj.2010.182</a>'
  chicago: 'Papusheva, Ekaterina, and Carl-Philipp J Heisenberg. “Spatial Organization
    of Adhesion: Force-Dependent Regulation and Function in Tissue Morphogenesis.”
    <i>EMBO Journal</i>. Wiley-Blackwell, 2010. <a href="https://doi.org/10.1038/emboj.2010.182">https://doi.org/10.1038/emboj.2010.182</a>.'
  ieee: 'E. Papusheva and C.-P. J. Heisenberg, “Spatial organization of adhesion:
    force-dependent regulation and function in tissue morphogenesis,” <i>EMBO Journal</i>,
    vol. 29, no. 16. Wiley-Blackwell, pp. 2753–2768, 2010.'
  ista: 'Papusheva E, Heisenberg C-PJ. 2010. Spatial organization of adhesion: force-dependent
    regulation and function in tissue morphogenesis. EMBO Journal. 29(16), 2753–2768.'
  mla: 'Papusheva, Ekaterina, and Carl-Philipp J. Heisenberg. “Spatial Organization
    of Adhesion: Force-Dependent Regulation and Function in Tissue Morphogenesis.”
    <i>EMBO Journal</i>, vol. 29, no. 16, Wiley-Blackwell, 2010, pp. 2753–68, doi:<a
    href="https://doi.org/10.1038/emboj.2010.182">10.1038/emboj.2010.182</a>.'
  short: E. Papusheva, C.-P.J. Heisenberg, EMBO Journal 29 (2010) 2753–2768.
date_created: 2018-12-11T12:07:17Z
date_published: 2010-08-18T00:00:00Z
date_updated: 2021-01-12T07:54:55Z
day: '18'
department:
- _id: Bio
- _id: CaHe
doi: 10.1038/emboj.2010.182
external_id:
  pmid:
  - '20717145'
intvolume: '        29'
issue: '16'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2924654/
month: '08'
oa: 1
oa_version: Submitted Version
page: 2753 - 2768
pmid: 1
publication: EMBO Journal
publication_status: published
publisher: Wiley-Blackwell
publist_id: '1962'
quality_controlled: '1'
scopus_import: 1
status: public
title: 'Spatial organization of adhesion: force-dependent regulation and function
  in tissue morphogenesis'
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 29
year: '2010'
...