---
_id: '3446'
abstract:
- lang: eng
  text: An effective character recognition procedure implemented on a new type of
    hardware system and using a new architecture called CNND is proposed. This CNND
    contains one or more analog cellular neural networks (CNNs) and some digital logic,
    combining the advantages of the fast analog CNN signal processing and the fast
    and easy decision capability of digital logic. It is shown that the CNND system
    can be used for recognition of multifont printed or handwritten characters and
    could recognize 100,000 char/s with a recognition rate of more than 95%. The more
    advantage of the system over competing types is that there is not an extra feature
    extraction procedure implemented in slow hardware
article_processing_charge: No
article_type: original
author:
- first_name: Tamas
  full_name: Sziranyi, Tamas
  last_name: Sziranyi
- first_name: Jozsef L
  full_name: Csicsvari, Jozsef L
  id: 3FA14672-F248-11E8-B48F-1D18A9856A87
  last_name: Csicsvari
  orcid: 0000-0002-5193-4036
citation:
  ama: 'Sziranyi T, Csicsvari JL. High-speed character recognition using a dual cellular
    neural network architecture (CNND). <i>IEEE Transactions on Circuits and Systems
    II: Analog and Digital Signal Processing</i>. 1993;40(3):223-231. doi:<a href="https://doi.org/10.1109/82.222823">10.1109/82.222823</a>'
  apa: 'Sziranyi, T., &#38; Csicsvari, J. L. (1993). High-speed character recognition
    using a dual cellular neural network architecture (CNND). <i>IEEE Transactions
    on Circuits and Systems II: Analog and Digital Signal Processing</i>. IEEE. <a
    href="https://doi.org/10.1109/82.222823">https://doi.org/10.1109/82.222823</a>'
  chicago: 'Sziranyi, Tamas, and Jozsef L Csicsvari. “High-Speed Character Recognition
    Using a Dual Cellular Neural Network Architecture (CNND).” <i>IEEE Transactions
    on Circuits and Systems II: Analog and Digital Signal Processing</i>. IEEE, 1993.
    <a href="https://doi.org/10.1109/82.222823">https://doi.org/10.1109/82.222823</a>.'
  ieee: 'T. Sziranyi and J. L. Csicsvari, “High-speed character recognition using
    a dual cellular neural network architecture (CNND),” <i>IEEE Transactions on Circuits
    and Systems II: Analog and Digital Signal Processing</i>, vol. 40, no. 3. IEEE,
    pp. 223–231, 1993.'
  ista: 'Sziranyi T, Csicsvari JL. 1993. High-speed character recognition using a
    dual cellular neural network architecture (CNND). IEEE Transactions on Circuits
    and Systems II: Analog and Digital Signal Processing. 40(3), 223–231.'
  mla: 'Sziranyi, Tamas, and Jozsef L. Csicsvari. “High-Speed Character Recognition
    Using a Dual Cellular Neural Network Architecture (CNND).” <i>IEEE Transactions
    on Circuits and Systems II: Analog and Digital Signal Processing</i>, vol. 40,
    no. 3, IEEE, 1993, pp. 223–31, doi:<a href="https://doi.org/10.1109/82.222823">10.1109/82.222823</a>.'
  short: 'T. Sziranyi, J.L. Csicsvari, IEEE Transactions on Circuits and Systems II:
    Analog and Digital Signal Processing 40 (1993) 223–231.'
date_created: 2018-12-11T12:03:22Z
date_published: 1993-03-01T00:00:00Z
date_updated: 2022-03-30T14:44:44Z
day: '01'
doi: 10.1109/82.222823
extern: '1'
intvolume: '        40'
issue: '3'
language:
- iso: eng
main_file_link:
- url: https://ieeexplore.ieee.org/document/222823
month: '03'
oa_version: None
page: 223 - 231
publication: 'IEEE Transactions on Circuits and Systems II: Analog and Digital Signal
  Processing'
publication_identifier:
  issn:
  - 1057-7130
publication_status: published
publisher: IEEE
publist_id: '2941'
quality_controlled: '1'
scopus_import: '1'
status: public
title: High-speed character recognition using a dual cellular neural network architecture
  (CNND)
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 40
year: '1993'
...
---
_id: '3451'
acknowledgement: I thank Prof. B. Sakmann for generous support and Drs. M. Häusser
  and A. Villarroel for critically reading the manuscript.
alternative_title:
- 'Annals of the New York Academy of Sciences '
article_processing_charge: No
author:
- first_name: Peter M
  full_name: Jonas, Peter M
  id: 353C1B58-F248-11E8-B48F-1D18A9856A87
  last_name: Jonas
  orcid: 0000-0001-5001-4804
citation:
  ama: 'Jonas PM. Glutamate receptors in the central nervous system. In: <i>Molecular
    Basis of Ion Channels and Receptors Involved in Nerve Excitation, Synaptic Transmission,
    and Muscle Contraction</i>. Vol 707. Annals of the New York Academy of Sciences.
    New York Academy of Sciences; 1993:126-135. doi:<a href="https://doi.org/10.1111/j.1749-6632.1993.tb38048.x">10.1111/j.1749-6632.1993.tb38048.x</a>'
  apa: Jonas, P. M. (1993). Glutamate receptors in the central nervous system. In
    <i>Molecular Basis of Ion Channels and Receptors Involved in Nerve Excitation,
    Synaptic Transmission, and Muscle Contraction</i> (Vol. 707, pp. 126–135). New
    York Academy of Sciences. <a href="https://doi.org/10.1111/j.1749-6632.1993.tb38048.x">https://doi.org/10.1111/j.1749-6632.1993.tb38048.x</a>
  chicago: Jonas, Peter M. “Glutamate Receptors in the Central Nervous System.” In
    <i>Molecular Basis of Ion Channels and Receptors Involved in Nerve Excitation,
    Synaptic Transmission, and Muscle Contraction</i>, 707:126–35. Annals of the New
    York Academy of Sciences. New York Academy of Sciences, 1993. <a href="https://doi.org/10.1111/j.1749-6632.1993.tb38048.x">https://doi.org/10.1111/j.1749-6632.1993.tb38048.x</a>.
  ieee: P. M. Jonas, “Glutamate receptors in the central nervous system,” in <i>Molecular
    Basis of Ion Channels and Receptors Involved in Nerve Excitation, Synaptic Transmission,
    and Muscle Contraction</i>, vol. 707, New York Academy of Sciences, 1993, pp.
    126–135.
  ista: 'Jonas PM. 1993.Glutamate receptors in the central nervous system. In: Molecular
    Basis of Ion Channels and Receptors Involved in Nerve Excitation, Synaptic Transmission,
    and Muscle Contraction. Annals of the New York Academy of Sciences , vol. 707,
    126–135.'
  mla: Jonas, Peter M. “Glutamate Receptors in the Central Nervous System.” <i>Molecular
    Basis of Ion Channels and Receptors Involved in Nerve Excitation, Synaptic Transmission,
    and Muscle Contraction</i>, vol. 707, New York Academy of Sciences, 1993, pp.
    126–35, doi:<a href="https://doi.org/10.1111/j.1749-6632.1993.tb38048.x">10.1111/j.1749-6632.1993.tb38048.x</a>.
  short: P.M. Jonas, in:, Molecular Basis of Ion Channels and Receptors Involved in
    Nerve Excitation, Synaptic Transmission, and Muscle Contraction, New York Academy
    of Sciences, 1993, pp. 126–135.
date_created: 2018-12-11T12:03:24Z
date_published: 1993-12-20T00:00:00Z
date_updated: 2022-03-30T12:35:23Z
day: '20'
doi: 10.1111/j.1749-6632.1993.tb38048.x
extern: '1'
external_id:
  pmid:
  - '9729204'
intvolume: '       707'
language:
- iso: eng
main_file_link:
- url: https://nyaspubs.onlinelibrary.wiley.com/doi/10.1111/j.1749-6632.1993.tb38048.x
month: '12'
oa_version: None
page: 126 - 135
pmid: 1
publication: Molecular Basis of Ion Channels and Receptors Involved in Nerve Excitation,
  Synaptic Transmission, and Muscle Contraction
publication_status: published
publisher: New York Academy of Sciences
publist_id: '2936'
quality_controlled: '1'
scopus_import: '1'
series_title: Annals of the New York Academy of Sciences
status: public
title: Glutamate receptors in the central nervous system
type: book_chapter
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 707
year: '1993'
...
---
_id: '3452'
abstract:
- lang: eng
  text: In recent years, considerable progress in our understanding of the molecular
    events underlying excitatory synaptic transmission has been made. This progress
    was mainly achieved by technical advances, among them the patch-clamp technique
    in brain slices (Edwards et al., 1989), fast application of agonists (Franke et
    al., 1987), and cloning and functional expression of GluR channels of the nonNMDA
    type (e.g., Hollmann et al., 1989). A suitable model for studying excitatory postsynaptic
    currents (EPSCs) in the brain slice with patch-clamp techniques is the mossy fiber
    synapse on CA3 pyramidal cells of rat hippocampus (MF-CA3 synapse). This synapse
    is located close to the cell soma and should provide almost ideal space-clamp
    conditions. A comparison of MF-CA3 EPSCs with the currents activated by fast application
    of glutamate on membrane patches isolated from CA3 cell somata suggests that the
    concentration of glutamate in the synaptic cleft during excitatory synaptic transmission
    is high (about 1 mM) and that the transmitter remains in the synaptic cleft only
    briefly (about 1 ms). It seems likely that desensitization influences the peak
    amplitude of the EPSC in several ways. Brief pulses of glutamate cause desensitization,
    from which the glutamate receptor channels recover only slowly, and micromolar
    ambient glutamate concentrations produce desensitization at equilibrium. From
    the functional properties of recombinant GluR channels, in situ hybridization
    data, and patch-clamp experiments on different neuronal and nonneuronal cell types,
    a picture of the molecular identity of native channels emerges. In neurons of
    the hippocampus the pharmacological features of these channels were similar to
    recombinant channels assembled from subunits of the AMPA/kainate subtype which
    are strongly expressed in these cells. The native channels are characterized by
    outward rectification of the steady-state I-V and low Ca permeability, similar
    to recombinant channels containing the GluR-B subunit. This is consistent with
    the ubiquitous expression of this subunit in hippocampal neurones. In contrast,
    GluR channels from cerebellar glial cells, which uniquely in the central nervous
    system lack the expression of GluR-B subunits, show double rectification and high
    Ca permeability. The results suggest that the native functional nonNMDA glutamate
    receptor channels in the CNS are assembled form subunits of the AMPA/kainate subtype
    in a cell-specific way, with the functional properties of GluR channels in neurones
    being dominated by the GluR-B subunit.
alternative_title:
- EXS
article_processing_charge: No
author:
- first_name: Peter M
  full_name: Jonas, Peter M
  id: 353C1B58-F248-11E8-B48F-1D18A9856A87
  last_name: Jonas
  orcid: 0000-0001-5001-4804
citation:
  ama: 'Jonas PM. AMPA-type glutamate receptors - nonselective cation channels mediating
    fast excitatory transmission in the CNS. In: Siemen D, ed. <i>Nonselective Cation
    Channels: Pharmacology, Physiology and Biophysics.</i> Vol 66. Birkhäuser; 1993:61-76.
    doi:<a href="https://doi.org/10.1007/978-3-0348-7327-7_4">10.1007/978-3-0348-7327-7_4</a>'
  apa: 'Jonas, P. M. (1993). AMPA-type glutamate receptors - nonselective cation channels
    mediating fast excitatory transmission in the CNS. In D. Siemen (Ed.), <i>Nonselective
    cation channels: Pharmacology, Physiology and Biophysics.</i> (Vol. 66, pp. 61–76).
    Birkhäuser. <a href="https://doi.org/10.1007/978-3-0348-7327-7_4">https://doi.org/10.1007/978-3-0348-7327-7_4</a>'
  chicago: 'Jonas, Peter M. “AMPA-Type Glutamate Receptors - Nonselective Cation Channels
    Mediating Fast Excitatory Transmission in the CNS.” In <i>Nonselective Cation
    Channels: Pharmacology, Physiology and Biophysics.</i>, edited by Detlef Siemen,
    66:61–76. Birkhäuser, 1993. <a href="https://doi.org/10.1007/978-3-0348-7327-7_4">https://doi.org/10.1007/978-3-0348-7327-7_4</a>.'
  ieee: 'P. M. Jonas, “AMPA-type glutamate receptors - nonselective cation channels
    mediating fast excitatory transmission in the CNS,” in <i>Nonselective cation
    channels: Pharmacology, Physiology and Biophysics.</i>, vol. 66, D. Siemen, Ed.
    Birkhäuser, 1993, pp. 61–76.'
  ista: 'Jonas PM. 1993.AMPA-type glutamate receptors - nonselective cation channels
    mediating fast excitatory transmission in the CNS. In: Nonselective cation channels:
    Pharmacology, Physiology and Biophysics. EXS, vol. 66, 61–76.'
  mla: 'Jonas, Peter M. “AMPA-Type Glutamate Receptors - Nonselective Cation Channels
    Mediating Fast Excitatory Transmission in the CNS.” <i>Nonselective Cation Channels:
    Pharmacology, Physiology and Biophysics.</i>, edited by Detlef Siemen, vol. 66,
    Birkhäuser, 1993, pp. 61–76, doi:<a href="https://doi.org/10.1007/978-3-0348-7327-7_4">10.1007/978-3-0348-7327-7_4</a>.'
  short: 'P.M. Jonas, in:, D. Siemen (Ed.), Nonselective Cation Channels: Pharmacology,
    Physiology and Biophysics., Birkhäuser, 1993, pp. 61–76.'
date_created: 2018-12-11T12:03:24Z
date_published: 1993-01-01T00:00:00Z
date_updated: 2022-03-30T11:46:44Z
day: '01'
doi: 10.1007/978-3-0348-7327-7_4
editor:
- first_name: Detlef
  full_name: Siemen, Detlef
  last_name: Siemen
extern: '1'
external_id:
  pmid:
  - '7505664'
intvolume: '        66'
language:
- iso: eng
main_file_link:
- url: https://link.springer.com/chapter/10.1007/978-3-0348-7327-7_4
month: '01'
oa_version: None
page: 61 - 76
pmid: 1
publication: 'Nonselective cation channels: Pharmacology, Physiology and Biophysics.'
publication_identifier:
  isbn:
  - 978-3-0348-7327-7
publication_status: published
publisher: Birkhäuser
publist_id: '2935'
quality_controlled: '1'
scopus_import: '1'
status: public
title: AMPA-type glutamate receptors - nonselective cation channels mediating fast
  excitatory transmission in the CNS
type: book_chapter
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 66
year: '1993'
...
---
_id: '3473'
abstract:
- lang: eng
  text: Sixteen different K+ channel subtypes have been cloned from mammalian tissue.
    Considering their sequence homology to Drosophila Shaker, Shab, Shaw and Shal
    channels, they were classified into four corresponding classes Kv1-4. All K+ channels
    belonging to these classes consist of four subunits with each six hydrophobic
    segments (S1-S6) and a characteristic structure-function relationship of certain
    domains in their amino acid sequence. These domains are, the inactivation gate
    in the N-terminal region of the sequence, the voltage sensor in the fourth hydrophobic
    segment (S4), and the pore-region in the H5 segment between S5 and S6. In some
    functional properties K+ channels cloned from the mammalian brain, however, differ
    from Drosophila K+ channels. These are pharmacological differences, differences
    in the threshold of activation and in regulation of inactivation. Part of these
    differences are important to understand their physiological role in the brain.
    Based on their functional characteristics the expression pattern of cloned K+
    channels in the rat brain can be correlated with the properties of K+ currents
    measured in central neurones.
article_processing_charge: No
article_type: original
author:
- first_name: Peter
  full_name: Ruppersberg, Peter
  last_name: Ruppersberg
- first_name: Mamfred
  full_name: Ermler, Mamfred
  last_name: Ermler
- first_name: Martin
  full_name: Knopf, Martin
  last_name: Knopf
- first_name: Wilfried
  full_name: Kues, Wilfried
  last_name: Kues
- first_name: Peter M
  full_name: Jonas, Peter M
  id: 353C1B58-F248-11E8-B48F-1D18A9856A87
  last_name: Jonas
  orcid: 0000-0001-5001-4804
- first_name: Michael
  full_name: Koenen, Michael
  last_name: Koenen
citation:
  ama: Ruppersberg P, Ermler M, Knopf M, Kues W, Jonas PM, Koenen M. Properties of
    Shaker-homologous potassium channels expressed in the mammalian brain. <i>Cellular
    Physiology and Biochemistry</i>. 1993;3:250-269. doi:<a href="https://doi.org/10.1159/000154691">10.1159/000154691</a>
  apa: Ruppersberg, P., Ermler, M., Knopf, M., Kues, W., Jonas, P. M., &#38; Koenen,
    M. (1993). Properties of Shaker-homologous potassium channels expressed in the
    mammalian brain. <i>Cellular Physiology and Biochemistry</i>. S. Karger AG. <a
    href="https://doi.org/10.1159/000154691">https://doi.org/10.1159/000154691</a>
  chicago: Ruppersberg, Peter, Mamfred Ermler, Martin Knopf, Wilfried Kues, Peter
    M Jonas, and Michael Koenen. “Properties of Shaker-Homologous Potassium Channels
    Expressed in the Mammalian Brain.” <i>Cellular Physiology and Biochemistry</i>.
    S. Karger AG, 1993. <a href="https://doi.org/10.1159/000154691">https://doi.org/10.1159/000154691</a>.
  ieee: P. Ruppersberg, M. Ermler, M. Knopf, W. Kues, P. M. Jonas, and M. Koenen,
    “Properties of Shaker-homologous potassium channels expressed in the mammalian
    brain.,” <i>Cellular Physiology and Biochemistry</i>, vol. 3. S. Karger AG, pp.
    250–269, 1993.
  ista: Ruppersberg P, Ermler M, Knopf M, Kues W, Jonas PM, Koenen M. 1993. Properties
    of Shaker-homologous potassium channels expressed in the mammalian brain. Cellular
    Physiology and Biochemistry. 3, 250–269.
  mla: Ruppersberg, Peter, et al. “Properties of Shaker-Homologous Potassium Channels
    Expressed in the Mammalian Brain.” <i>Cellular Physiology and Biochemistry</i>,
    vol. 3, S. Karger AG, 1993, pp. 250–69, doi:<a href="https://doi.org/10.1159/000154691">10.1159/000154691</a>.
  short: P. Ruppersberg, M. Ermler, M. Knopf, W. Kues, P.M. Jonas, M. Koenen, Cellular
    Physiology and Biochemistry 3 (1993) 250–269.
date_created: 2018-12-11T12:03:31Z
date_published: 1993-01-01T00:00:00Z
date_updated: 2022-03-30T10:21:04Z
day: '01'
doi: 10.1159/000154691
extern: '1'
intvolume: '         3'
language:
- iso: eng
main_file_link:
- url: https://www.karger.com/Article/Abstract/154691
month: '01'
oa_version: None
page: 250 - 269
publication: Cellular Physiology and Biochemistry
publication_identifier:
  issn:
  - 1015-8987
publication_status: published
publisher: S. Karger AG
publist_id: '2914'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Properties of Shaker-homologous potassium channels expressed in the mammalian
  brain.
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 3
year: '1993'
...
---
_id: '3474'
abstract:
- lang: eng
  text: 1. Excitatory postsynaptic currents (EPSCs) were recorded in CA3 pyramidal
    cells of hippocampal slices of 15- to 24-day-old rats (22 degrees C) using the
    whole-cell configuration of the patch clamp technique. 2. Composite EPSCs were
    evoked by extracellular stimulation of the mossy fibre tract. Using the selective
    blockers 6-cyano-7-nitroquinoxaline-2,3-dione (CNQX) and D-2-amino-5-phosphonopentanoic
    acid (APV), a major alpha-amino-3-hydroxy-5-methylisoxazole-4-propionate (AMPA)/kainate
    receptor-mediated component and a minor NMDA receptor-mediated component with
    slower time course were distinguished. For the AMPA/kainate receptor-mediated
    component, the peak current-voltage (I-V) relation was linear, with a reversal
    potential close to 0 mV. The half-maximal blocking concentration of CNQX was 353
    nM. 3. Unitary EPSCs of the mossy fibre terminal (MF)-CA3 pyramidal cell synapse
    were evoked at membrane potentials of -70 to -90 mV by low-intensity extracellular
    stimulation of granule cell somata using fine-tipped pipettes. The EPSC peak amplitude
    as a function of stimulus intensity showed all-or-none behaviour. The region of
    low threshold was restricted to a few micrometres. This suggests that extracellular
    stimulation was focal, and that the stimulus-evoked EPSCs were unitary. 4. Latency
    and rise time histograms of EPSCs evoked by granule cell stimulation showed narrow
    unimodal distributions within each experiment. The mean latency was 4.2 +/- 1.0
    ms, and the mean 20-80% rise time was 0.6 +/- 0.1 ms (23 cells). When fitted within
    the range 0.7 ms to 20 ms after the peak, the decay of the EPSCs with the fastest
    rise (rise time 0.5 ms or less) could be described by a single exponential function;
    the mean time constant was in the range 3.0-6.6 ms with a mean of 4.8 ms (8 cells).
    5. Peak amplitudes of the EPSCs evoked by suprathreshold granule cell stimulation
    fluctuated between trials. The apparent EPSC peak conductance in normal extracellular
    solution (2 mM Ca2+, 1 mM Mg2+), excluding failures, was 1 nS. Reducing the Ca2+
    concentration and increasing the Mg2+ concentration reduced the mean peak amplitude
    in a concentration-dependent manner. 6. Peaks in EPSC peak amplitude distributions
    were apparent in low Ca2+ and high Mg2+. Using the criteria of equidistance and
    the presence of peaks and dips in the autocorrelation function, five of nine EPSC
    peak amplitude distributions were judged to be quantal.
acknowledgement: "We are indebted to Professor B. Katz for critically reading the
  manuscript and for helpful suggestions. We especially thank Professor D. Colquhoun
  for several discussions, for generously providing the source codes of programs for
  maximum-likelihood fit with sums of Gaussian functions, a routine for calculating
  the error function and for critically reading the manuscript. We also thank Drs
  A. Larkman, P. Ruppersberg, N. Spuston and G. Stuart for critically reading the
  manuscript, P. Andersen, B. Betz, J. Evans, K. Harris, E. v. Kitzing, R. Rahamimov
  and K. Stratford for helpful discussions, and J. J. B. Jack for much-needed advice
  and guidance to G.M. We thank K. Bauer, F. Helmchen, M. Huke, B. Manz and especially
  A. Roth for computer programming, B. Werner for typing the manuscript, and M. Kaiser
  for excellent technical assistance. Part of the project was supported by the Deutsche
  Forschungsgemeinschaft (SFB-317)\r\nand the Wellcome Trust."
article_processing_charge: No
article_type: original
author:
- first_name: Peter M
  full_name: Jonas, Peter M
  id: 353C1B58-F248-11E8-B48F-1D18A9856A87
  last_name: Jonas
  orcid: 0000-0001-5001-4804
- first_name: Guy
  full_name: Major, Guy
  last_name: Major
- first_name: Bert
  full_name: Sakmann, Bert
  last_name: Sakmann
citation:
  ama: Jonas PM, Major G, Sakmann B. Quantal components of unitary EPSCs at the mossy
    fibre synapse on CA3 pyramidal cells of rat hippocampus. <i>Journal of Physiology</i>.
    1993;472:615-663. doi:<a href="https://doi.org/10.1113/jphysiol.1993.sp019965">10.1113/jphysiol.1993.sp019965</a>
  apa: Jonas, P. M., Major, G., &#38; Sakmann, B. (1993). Quantal components of unitary
    EPSCs at the mossy fibre synapse on CA3 pyramidal cells of rat hippocampus. <i>Journal
    of Physiology</i>. Wiley-Blackwell. <a href="https://doi.org/10.1113/jphysiol.1993.sp019965">https://doi.org/10.1113/jphysiol.1993.sp019965</a>
  chicago: Jonas, Peter M, Guy Major, and Bert Sakmann. “Quantal Components of Unitary
    EPSCs at the Mossy Fibre Synapse on CA3 Pyramidal Cells of Rat Hippocampus.” <i>Journal
    of Physiology</i>. Wiley-Blackwell, 1993. <a href="https://doi.org/10.1113/jphysiol.1993.sp019965">https://doi.org/10.1113/jphysiol.1993.sp019965</a>.
  ieee: P. M. Jonas, G. Major, and B. Sakmann, “Quantal components of unitary EPSCs
    at the mossy fibre synapse on CA3 pyramidal cells of rat hippocampus,” <i>Journal
    of Physiology</i>, vol. 472. Wiley-Blackwell, pp. 615–663, 1993.
  ista: Jonas PM, Major G, Sakmann B. 1993. Quantal components of unitary EPSCs at
    the mossy fibre synapse on CA3 pyramidal cells of rat hippocampus. Journal of
    Physiology. 472, 615–663.
  mla: Jonas, Peter M., et al. “Quantal Components of Unitary EPSCs at the Mossy Fibre
    Synapse on CA3 Pyramidal Cells of Rat Hippocampus.” <i>Journal of Physiology</i>,
    vol. 472, Wiley-Blackwell, 1993, pp. 615–63, doi:<a href="https://doi.org/10.1113/jphysiol.1993.sp019965">10.1113/jphysiol.1993.sp019965</a>.
  short: P.M. Jonas, G. Major, B. Sakmann, Journal of Physiology 472 (1993) 615–663.
date_created: 2018-12-11T12:03:31Z
date_published: 1993-12-01T00:00:00Z
date_updated: 2022-03-30T09:33:19Z
day: '01'
doi: 10.1113/jphysiol.1993.sp019965
extern: '1'
external_id:
  pmid:
  - '7908327'
intvolume: '       472'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1160505
month: '12'
oa: 1
oa_version: Published Version
page: 615 - 663
pmid: 1
publication: Journal of Physiology
publication_identifier:
  issn:
  - 0022-3751
publication_status: published
publisher: Wiley-Blackwell
publist_id: '2913'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Quantal components of unitary EPSCs at the mossy fibre synapse on CA3 pyramidal
  cells of rat hippocampus
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 472
year: '1993'
...
---
_id: '3568'
article_processing_charge: No
author:
- first_name: Herbert
  full_name: Edelsbrunner, Herbert
  id: 3FB178DA-F248-11E8-B48F-1D18A9856A87
  last_name: Edelsbrunner
  orcid: 0000-0002-9823-6833
citation:
  ama: 'Edelsbrunner H. Geometric algorithms. In: <i>Handbook of Convex Geometry</i>.
    North Holland; 1993:699-735. doi:<a href="https://doi.org/10.1016/C2009-0-15705-7">10.1016/C2009-0-15705-7</a>'
  apa: Edelsbrunner, H. (1993). Geometric algorithms. In <i>Handbook of Convex Geometry</i>
    (pp. 699–735). North Holland. <a href="https://doi.org/10.1016/C2009-0-15705-7">https://doi.org/10.1016/C2009-0-15705-7</a>
  chicago: Edelsbrunner, Herbert. “Geometric Algorithms.” In <i>Handbook of Convex
    Geometry</i>, 699–735. North Holland, 1993. <a href="https://doi.org/10.1016/C2009-0-15705-7">https://doi.org/10.1016/C2009-0-15705-7</a>.
  ieee: H. Edelsbrunner, “Geometric algorithms,” in <i>Handbook of Convex Geometry</i>,
    North Holland, 1993, pp. 699–735.
  ista: 'Edelsbrunner H. 1993.Geometric algorithms. In: Handbook of Convex Geometry.
    , 699–735.'
  mla: Edelsbrunner, Herbert. “Geometric Algorithms.” <i>Handbook of Convex Geometry</i>,
    North Holland, 1993, pp. 699–735, doi:<a href="https://doi.org/10.1016/C2009-0-15705-7">10.1016/C2009-0-15705-7</a>.
  short: H. Edelsbrunner, in:, Handbook of Convex Geometry, North Holland, 1993, pp.
    699–735.
date_created: 2018-12-11T12:04:00Z
date_published: 1993-08-24T00:00:00Z
date_updated: 2022-03-30T09:30:11Z
day: '24'
doi: 10.1016/C2009-0-15705-7
extern: '1'
language:
- iso: eng
main_file_link:
- url: https://www.sciencedirect.com/book/9780444895967/handbook-of-convex-geometry
month: '08'
oa_version: None
page: 699 - 735
publication: Handbook of Convex Geometry
publication_identifier:
  isbn:
  - 978-0-444-89596-7
publication_status: published
publisher: North Holland
publist_id: '2817'
status: public
title: Geometric algorithms
type: book_chapter
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
year: '1993'
...
---
_id: '3569'
article_processing_charge: No
author:
- first_name: Herbert
  full_name: Edelsbrunner, Herbert
  id: 3FB178DA-F248-11E8-B48F-1D18A9856A87
  last_name: Edelsbrunner
  orcid: 0000-0002-9823-6833
citation:
  ama: 'Edelsbrunner H. Computational geometry. In: <i>Current Trends in Theoretical
    Computer Science, Essays and Tutorials</i>. World Scientific Publishing; 1993:1-48.'
  apa: Edelsbrunner, H. (1993). Computational geometry. In <i>Current Trends in Theoretical
    Computer Science, Essays and Tutorials</i> (pp. 1–48). World Scientific Publishing.
  chicago: Edelsbrunner, Herbert. “Computational Geometry.” In <i>Current Trends in
    Theoretical Computer Science, Essays and Tutorials</i>, 1–48. World Scientific
    Publishing, 1993.
  ieee: H. Edelsbrunner, “Computational geometry,” in <i>Current Trends in Theoretical
    Computer Science, Essays and Tutorials</i>, World Scientific Publishing, 1993,
    pp. 1–48.
  ista: 'Edelsbrunner H. 1993.Computational geometry. In: Current Trends in Theoretical
    Computer Science, Essays and Tutorials. , 1–48.'
  mla: Edelsbrunner, Herbert. “Computational Geometry.” <i>Current Trends in Theoretical
    Computer Science, Essays and Tutorials</i>, World Scientific Publishing, 1993,
    pp. 1–48.
  short: H. Edelsbrunner, in:, Current Trends in Theoretical Computer Science, Essays
    and Tutorials, World Scientific Publishing, 1993, pp. 1–48.
date_created: 2018-12-11T12:04:01Z
date_published: 1993-08-01T00:00:00Z
date_updated: 2022-03-30T08:46:20Z
day: '01'
extern: '1'
language:
- iso: eng
main_file_link:
- url: https://books.google.at/books?hl=en&lr=&id=fr_sCgAAQBAJ&oi=fnd&pg=PR5&ots=XAust-LAGl&sig=FQTlA5rrM25y5EZ8ZmrorT7SaMo&redir_esc=y#v=onepage&q&f=false
month: '08'
oa_version: None
page: 1 - 48
publication: Current Trends in Theoretical Computer Science, Essays and Tutorials
publication_identifier:
  isbn:
  - 978-9810214623
publication_status: published
publisher: World Scientific Publishing
publist_id: '2816'
status: public
title: Computational geometry
type: book_chapter
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
year: '1993'
...
---
_id: '3643'
abstract:
- lang: eng
  text: 'We investigate the establishment and spread of new adaptive peaks within
    Wright''s ‘shifting balance’. The third phase of the ‘shifting balance’ involves
    a kind of group selection, since demes in which a superior peak has been established
    contain more individuals, and so send out more migrants. We assume that population
    size, N, increases with mean fitness, , according to the exponential relation,
    . Here, k is a measure of the weakness of density-dependent regulation, and equals
    the inverse of the regression of log (fitness) on log(N). In the island model,
    we find that just as with soft selection (k = 0), two distinct types of behaviour
    exist: group selection makes no qualitative difference. With low numbers of migrants,
    demes fluctuate almost independently, and only one equilibrium exists. With large
    numbers of migrants, all the demes evolve towards the same adaptive peak, and
    so the whole population can move towards one or other of the peaks. Group selection
    can be understood in terms of an effective mean fitness function. Its main consequence
    is to increase the effect of selection relative to drift (Ns), and so increase
    the bias towards the fitter peak. However, this increased bias depends on the
    ratio between k and the deme size (k/N), and so is very small when density-dependence
    is reasonably strong.'
acknowledgement: 'This work was supported by the Darwin Trust, by a Science and Engineering
  Research Council grant (GR/E/08507), and by an SERC Visiting Fellowship to S.Rouhani. '
article_processing_charge: No
article_type: original
author:
- first_name: Shahin
  full_name: Rouhani, Shahin
  last_name: Rouhani
- first_name: Nicholas H
  full_name: Barton, Nicholas H
  id: 4880FE40-F248-11E8-B48F-1D18A9856A87
  last_name: Barton
  orcid: 0000-0002-8548-5240
citation:
  ama: Rouhani S, Barton NH. Group selection and the “shifting balance.” <i>Genetical
    Research</i>. 1993;61(2):127-136. doi:<a href="https://doi.org/10.1017/S0016672300031232">10.1017/S0016672300031232</a>
  apa: Rouhani, S., &#38; Barton, N. H. (1993). Group selection and the “shifting
    balance.” <i>Genetical Research</i>. Cambridge University Press. <a href="https://doi.org/10.1017/S0016672300031232">https://doi.org/10.1017/S0016672300031232</a>
  chicago: Rouhani, Shahin, and Nicholas H Barton. “Group Selection and the ‘Shifting
    Balance.’” <i>Genetical Research</i>. Cambridge University Press, 1993. <a href="https://doi.org/10.1017/S0016672300031232">https://doi.org/10.1017/S0016672300031232</a>.
  ieee: S. Rouhani and N. H. Barton, “Group selection and the ‘shifting balance,’”
    <i>Genetical Research</i>, vol. 61, no. 2. Cambridge University Press, pp. 127–136,
    1993.
  ista: Rouhani S, Barton NH. 1993. Group selection and the ‘shifting balance’. Genetical
    Research. 61(2), 127–136.
  mla: Rouhani, Shahin, and Nicholas H. Barton. “Group Selection and the ‘Shifting
    Balance.’” <i>Genetical Research</i>, vol. 61, no. 2, Cambridge University Press,
    1993, pp. 127–36, doi:<a href="https://doi.org/10.1017/S0016672300031232">10.1017/S0016672300031232</a>.
  short: S. Rouhani, N.H. Barton, Genetical Research 61 (1993) 127–136.
date_created: 2018-12-11T12:04:24Z
date_published: 1993-04-01T00:00:00Z
date_updated: 2022-03-30T08:28:54Z
day: '01'
doi: 10.1017/S0016672300031232
extern: '1'
intvolume: '        61'
issue: '2'
language:
- iso: eng
main_file_link:
- url: https://www.cambridge.org/core/journals/genetics-research/article/group-selection-and-the-shifting-balance/CFDE26EA7125957545F9A0AA37755BC4
month: '04'
oa_version: None
page: 127 - 136
publication: Genetical Research
publication_identifier:
  issn:
  - 0016-6723
publication_status: published
publisher: Cambridge University Press
publist_id: '2740'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Group selection and the 'shifting balance'
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 61
year: '1993'
...
---
_id: '3644'
abstract:
- lang: eng
  text: "Wright proposed that there is a ' shifting balance' between selection within
    demes, random drift, and selection between demes at different 'adaptive peaks'.
    We investigate the establishment and spread of new adaptive peaks, considering
    a chromosome rearrangement, and a polygenic character under disruptive selection.
    When the number of migrants (Nm) is small, demes fluctuate independently, with
    a bias towards the fitter peak. When Nm is large, the whole population can\r\nmove
    to one of two stable equilibria, and so can be trapped near the lower peak. These
    two regimes are separated by a sharp transition at a critical Nm of order 1. Just
    below this critical point, adaptation is most efficient, since the shifting balance
    greatly increases the proportion of demes that reach the global optimum. This
    is so even if one peak is only slightly fitter than the other (AWx \\/N), and
    for both strong and weak selection (Ns <§ 1 or Ns > 1). Provided that Nm\r\nvaries
    sufficiently gradually from place to place, the fitter peak can be established
    in regions where Nm « 1, and can then spread through the rest of the range. Our
    analysis confirms Wright's argument that if selection, migration and drift are
    of the same order, the ' shifting balance' leads to efficient evolution towards
    the global optimum."
article_processing_charge: No
article_type: original
author:
- first_name: Nicholas H
  full_name: Barton, Nicholas H
  id: 4880FE40-F248-11E8-B48F-1D18A9856A87
  last_name: Barton
  orcid: 0000-0002-8548-5240
- first_name: Shahin
  full_name: Rouhani, Shahin
  last_name: Rouhani
citation:
  ama: Barton NH, Rouhani S. Adaptation and the “shifting balance.” <i>Genetical Research</i>.
    1993;61(1):57-74. doi:<a href="https://doi.org/10.1017/S0016672300031098 ">10.1017/S0016672300031098
    </a>
  apa: Barton, N. H., &#38; Rouhani, S. (1993). Adaptation and the “shifting balance.”
    <i>Genetical Research</i>. Cambridge University Press. <a href="https://doi.org/10.1017/S0016672300031098
    ">https://doi.org/10.1017/S0016672300031098 </a>
  chicago: Barton, Nicholas H, and Shahin Rouhani. “Adaptation and the ‘Shifting Balance.’”
    <i>Genetical Research</i>. Cambridge University Press, 1993. <a href="https://doi.org/10.1017/S0016672300031098
    ">https://doi.org/10.1017/S0016672300031098 </a>.
  ieee: N. H. Barton and S. Rouhani, “Adaptation and the ‘shifting balance,’” <i>Genetical
    Research</i>, vol. 61, no. 1. Cambridge University Press, pp. 57–74, 1993.
  ista: Barton NH, Rouhani S. 1993. Adaptation and the ‘shifting balance’. Genetical
    Research. 61(1), 57–74.
  mla: Barton, Nicholas H., and Shahin Rouhani. “Adaptation and the ‘Shifting Balance.’”
    <i>Genetical Research</i>, vol. 61, no. 1, Cambridge University Press, 1993, pp.
    57–74, doi:<a href="https://doi.org/10.1017/S0016672300031098 ">10.1017/S0016672300031098
    </a>.
  short: N.H. Barton, S. Rouhani, Genetical Research 61 (1993) 57–74.
date_created: 2018-12-11T12:04:24Z
date_published: 1993-02-01T00:00:00Z
date_updated: 2022-03-30T08:18:58Z
day: '01'
doi: '10.1017/S0016672300031098 '
extern: '1'
intvolume: '        61'
issue: '1'
language:
- iso: eng
main_file_link:
- url: https://www.cambridge.org/core/journals/genetics-research/article/adaptation-and-the-shifting-balance/2E15452B3AFCA97E77743E0C7E108064
month: '02'
oa_version: None
page: 57 - 74
publication: Genetical Research
publication_identifier:
  issn:
  - 0016-6723
publication_status: published
publisher: Cambridge University Press
publist_id: '2739'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Adaptation and the 'shifting balance'
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 61
year: '1993'
...
---
_id: '4036'
abstract:
- lang: eng
  text: This paper presents a randomized incremental algorithm for computing a single
    face in an arrangement of n line segments in the plane that is fairly simple to
    implement. The expected running time of the algorithm is O(nα(n)log n). The analysis
    of the algorithm uses a novel approach that generalizes and extends the Clarkson-Shor
    analysis technique [in Discrete Comput. Geom., 4(1989), pp. 387-421]. A few extensions
    of the technique, obtaining efficient randomized incremental algorithms for constructing
    the entire arrangement of a collection of line segments and for computing a single
    face in an arrangement of Jordan arcs are also presented.
acknowledgement: The authors wish to express their gratitude for the generous support
  and hospitality of the DEC Palo Alto Systems Research Center.
article_processing_charge: No
article_type: original
author:
- first_name: Bernard
  full_name: Chazelle, Bernard
  last_name: Chazelle
- first_name: Herbert
  full_name: Edelsbrunner, Herbert
  id: 3FB178DA-F248-11E8-B48F-1D18A9856A87
  last_name: Edelsbrunner
  orcid: 0000-0002-9823-6833
- first_name: Leonidas
  full_name: Guibas, Leonidas
  last_name: Guibas
- first_name: Micha
  full_name: Sharir, Micha
  last_name: Sharir
- first_name: Jack
  full_name: Snoeyink, Jack
  last_name: Snoeyink
citation:
  ama: Chazelle B, Edelsbrunner H, Guibas L, Sharir M, Snoeyink J. Computing a face
    in an arrangement of line segments and related problems. <i>SIAM Journal on Computing</i>.
    1993;22(6):1286-1302. doi:<a href="https://doi.org/10.1137/0222077 ">10.1137/0222077
    </a>
  apa: Chazelle, B., Edelsbrunner, H., Guibas, L., Sharir, M., &#38; Snoeyink, J.
    (1993). Computing a face in an arrangement of line segments and related problems.
    <i>SIAM Journal on Computing</i>. SIAM. <a href="https://doi.org/10.1137/0222077
    ">https://doi.org/10.1137/0222077 </a>
  chicago: Chazelle, Bernard, Herbert Edelsbrunner, Leonidas Guibas, Micha Sharir,
    and Jack Snoeyink. “Computing a Face in an Arrangement of Line Segments and Related
    Problems.” <i>SIAM Journal on Computing</i>. SIAM, 1993. <a href="https://doi.org/10.1137/0222077
    ">https://doi.org/10.1137/0222077 </a>.
  ieee: B. Chazelle, H. Edelsbrunner, L. Guibas, M. Sharir, and J. Snoeyink, “Computing
    a face in an arrangement of line segments and related problems,” <i>SIAM Journal
    on Computing</i>, vol. 22, no. 6. SIAM, pp. 1286–1302, 1993.
  ista: Chazelle B, Edelsbrunner H, Guibas L, Sharir M, Snoeyink J. 1993. Computing
    a face in an arrangement of line segments and related problems. SIAM Journal on
    Computing. 22(6), 1286–1302.
  mla: Chazelle, Bernard, et al. “Computing a Face in an Arrangement of Line Segments
    and Related Problems.” <i>SIAM Journal on Computing</i>, vol. 22, no. 6, SIAM,
    1993, pp. 1286–302, doi:<a href="https://doi.org/10.1137/0222077 ">10.1137/0222077
    </a>.
  short: B. Chazelle, H. Edelsbrunner, L. Guibas, M. Sharir, J. Snoeyink, SIAM Journal
    on Computing 22 (1993) 1286–1302.
date_created: 2018-12-11T12:06:34Z
date_published: 1993-12-01T00:00:00Z
date_updated: 2022-03-30T08:07:21Z
day: '01'
doi: '10.1137/0222077 '
extern: '1'
intvolume: '        22'
issue: '6'
language:
- iso: eng
main_file_link:
- url: https://epubs.siam.org/doi/10.1137/0222077
month: '12'
oa_version: None
page: 1286 - 1302
publication: SIAM Journal on Computing
publication_identifier:
  issn:
  - 0097-5397
publication_status: published
publisher: SIAM
publist_id: '2087'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Computing a face in an arrangement of line segments and related problems
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 22
year: '1993'
...
---
_id: '4040'
abstract:
- lang: eng
  text: A plane geometric graph C in ℝ2 conforms to another such graph G if each edge
    of G is the union of some edges of C. It is proved that, for every G with n vertices
    and m edges, there is a completion of a Delaunay triangulation of O(m2 n) points
    that conforms to G. The algorithm that constructs the points is also described.
acknowledgement: 'Research of the first author is supported by the National Science
  Foundation under Grant CCR-8921421 and under the Alan T. Waterman award, Grant CCR-9118874.
  Any opinions, findings, and conclusions or recommendations expressed in this publication
  are those of the authors and do not necessarily reflect the view of the National
  Science Foundation. Work of the second author was conducted while he was on study
  leave at the University of Illinois. '
article_processing_charge: No
article_type: original
author:
- first_name: Herbert
  full_name: Edelsbrunner, Herbert
  id: 3FB178DA-F248-11E8-B48F-1D18A9856A87
  last_name: Edelsbrunner
  orcid: 0000-0002-9823-6833
- first_name: Tiow
  full_name: Tan, Tiow
  last_name: Tan
citation:
  ama: Edelsbrunner H, Tan T. An upper bound for conforming Delaunay triangulations.
    <i>Discrete &#38; Computational Geometry</i>. 1993;10(1):197-213. doi:<a href="https://doi.org/10.1007/BF02573974">10.1007/BF02573974</a>
  apa: Edelsbrunner, H., &#38; Tan, T. (1993). An upper bound for conforming Delaunay
    triangulations. <i>Discrete &#38; Computational Geometry</i>. Springer. <a href="https://doi.org/10.1007/BF02573974">https://doi.org/10.1007/BF02573974</a>
  chicago: Edelsbrunner, Herbert, and Tiow Tan. “An Upper Bound for Conforming Delaunay
    Triangulations.” <i>Discrete &#38; Computational Geometry</i>. Springer, 1993.
    <a href="https://doi.org/10.1007/BF02573974">https://doi.org/10.1007/BF02573974</a>.
  ieee: H. Edelsbrunner and T. Tan, “An upper bound for conforming Delaunay triangulations,”
    <i>Discrete &#38; Computational Geometry</i>, vol. 10, no. 1. Springer, pp. 197–213,
    1993.
  ista: Edelsbrunner H, Tan T. 1993. An upper bound for conforming Delaunay triangulations.
    Discrete &#38; Computational Geometry. 10(1), 197–213.
  mla: Edelsbrunner, Herbert, and Tiow Tan. “An Upper Bound for Conforming Delaunay
    Triangulations.” <i>Discrete &#38; Computational Geometry</i>, vol. 10, no. 1,
    Springer, 1993, pp. 197–213, doi:<a href="https://doi.org/10.1007/BF02573974">10.1007/BF02573974</a>.
  short: H. Edelsbrunner, T. Tan, Discrete &#38; Computational Geometry 10 (1993)
    197–213.
date_created: 2018-12-11T12:06:35Z
date_published: 1993-12-01T00:00:00Z
date_updated: 2022-03-28T14:58:16Z
day: '01'
doi: 10.1007/BF02573974
extern: '1'
intvolume: '        10'
issue: '1'
language:
- iso: eng
main_file_link:
- url: https://link.springer.com/article/10.1007/BF02573974
month: '12'
oa_version: None
page: 197 - 213
publication: Discrete & Computational Geometry
publication_identifier:
  issn:
  - 0179-5376
publication_status: published
publisher: Springer
publist_id: '2084'
quality_controlled: '1'
status: public
title: An upper bound for conforming Delaunay triangulations
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 10
year: '1993'
...
---
_id: '4041'
abstract:
- lang: eng
  text: The zone theorem for an arrangement of n hyperplanes in d-dimensional real
    space says that the total number of faces bounding the cells intersected by another
    hyperplane is O(n(d-1)). This result is the basis of a time-optimal incremental
    algorithm that constructs a hyperplane arrangement and has a host of other algorithmic
    and combinatorial applications. Unfortunately, the original proof of the zone
    theorem, for d greater-than-or-equal-to 3, turned out to contain a serious and
    irreparable error. This paper presents a new proof of the theorem. The proof is
    based on an inductive argument, which also applies in the case of pseudohyperplane
    arrangements. The fallacies of the old proof along with some ways of partially
    saving that approach are briefly discussed.
acknowledgement: National Science Foundation under grant CCR-89- 21421.
article_processing_charge: No
article_type: original
author:
- first_name: Herbert
  full_name: Edelsbrunner, Herbert
  id: 3FB178DA-F248-11E8-B48F-1D18A9856A87
  last_name: Edelsbrunner
  orcid: 0000-0002-9823-6833
- first_name: Raimund
  full_name: Seidel, Raimund
  last_name: Seidel
- first_name: Micha
  full_name: Sharir, Micha
  last_name: Sharir
citation:
  ama: Edelsbrunner H, Seidel R, Sharir M. On the zone theorem for hyperplane arrangements.
    <i>SIAM Journal on Computing</i>. 1993;22(2):418-429. doi:<a href="https://doi.org/10.1137/0222031">10.1137/0222031</a>
  apa: Edelsbrunner, H., Seidel, R., &#38; Sharir, M. (1993). On the zone theorem
    for hyperplane arrangements. <i>SIAM Journal on Computing</i>. SIAM. <a href="https://doi.org/10.1137/0222031">https://doi.org/10.1137/0222031</a>
  chicago: Edelsbrunner, Herbert, Raimund Seidel, and Micha Sharir. “On the Zone Theorem
    for Hyperplane Arrangements.” <i>SIAM Journal on Computing</i>. SIAM, 1993. <a
    href="https://doi.org/10.1137/0222031">https://doi.org/10.1137/0222031</a>.
  ieee: H. Edelsbrunner, R. Seidel, and M. Sharir, “On the zone theorem for hyperplane
    arrangements,” <i>SIAM Journal on Computing</i>, vol. 22, no. 2. SIAM, pp. 418–429,
    1993.
  ista: Edelsbrunner H, Seidel R, Sharir M. 1993. On the zone theorem for hyperplane
    arrangements. SIAM Journal on Computing. 22(2), 418–429.
  mla: Edelsbrunner, Herbert, et al. “On the Zone Theorem for Hyperplane Arrangements.”
    <i>SIAM Journal on Computing</i>, vol. 22, no. 2, SIAM, 1993, pp. 418–29, doi:<a
    href="https://doi.org/10.1137/0222031">10.1137/0222031</a>.
  short: H. Edelsbrunner, R. Seidel, M. Sharir, SIAM Journal on Computing 22 (1993)
    418–429.
date_created: 2018-12-11T12:06:35Z
date_published: 1993-04-01T00:00:00Z
date_updated: 2022-03-29T13:25:02Z
day: '01'
doi: 10.1137/0222031
extern: '1'
intvolume: '        22'
issue: '2'
language:
- iso: eng
main_file_link:
- url: https://epubs.siam.org/doi/10.1137/0222031
month: '04'
oa_version: None
page: 418 - 429
publication: SIAM Journal on Computing
publication_identifier:
  issn:
  - 0097-5397
publication_status: published
publisher: SIAM
publist_id: '2085'
quality_controlled: '1'
scopus_import: '1'
status: public
title: On the zone theorem for hyperplane arrangements
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 22
year: '1993'
...
---
_id: '4042'
abstract:
- lang: eng
  text: It is shown that a triangulation of a set of n points in the plane that minimizes
    the maximum edge length can be computed in time 0(n2). The algorithm is reasonably
    easy to implement and is based on the theorem that there is a triangulation with
    minmax edge length that contains the relative neighborhood graph of the points
    as a subgraph. With minor modifications the algorithm works for arbitrary normed
    metrics.
acknowledgement: The authors thank an anonymous referee for suggestions on the organization
  of this paper.
article_processing_charge: No
article_type: original
author:
- first_name: Herbert
  full_name: Edelsbrunner, Herbert
  id: 3FB178DA-F248-11E8-B48F-1D18A9856A87
  last_name: Edelsbrunner
  orcid: 0000-0002-9823-6833
- first_name: Tiow
  full_name: Tan, Tiow
  last_name: Tan
citation:
  ama: Edelsbrunner H, Tan T. A quadratic time algorithm for the minmax length triangulation.
    <i>SIAM Journal on Computing</i>. 1993;22(3):527-551. doi:<a href="https://doi.org/10.1137/0222036
    ">10.1137/0222036 </a>
  apa: Edelsbrunner, H., &#38; Tan, T. (1993). A quadratic time algorithm for the
    minmax length triangulation. <i>SIAM Journal on Computing</i>. SIAM. <a href="https://doi.org/10.1137/0222036
    ">https://doi.org/10.1137/0222036 </a>
  chicago: Edelsbrunner, Herbert, and Tiow Tan. “A Quadratic Time Algorithm for the
    Minmax Length Triangulation.” <i>SIAM Journal on Computing</i>. SIAM, 1993. <a
    href="https://doi.org/10.1137/0222036 ">https://doi.org/10.1137/0222036 </a>.
  ieee: H. Edelsbrunner and T. Tan, “A quadratic time algorithm for the minmax length
    triangulation,” <i>SIAM Journal on Computing</i>, vol. 22, no. 3. SIAM, pp. 527–551,
    1993.
  ista: Edelsbrunner H, Tan T. 1993. A quadratic time algorithm for the minmax length
    triangulation. SIAM Journal on Computing. 22(3), 527–551.
  mla: Edelsbrunner, Herbert, and Tiow Tan. “A Quadratic Time Algorithm for the Minmax
    Length Triangulation.” <i>SIAM Journal on Computing</i>, vol. 22, no. 3, SIAM,
    1993, pp. 527–51, doi:<a href="https://doi.org/10.1137/0222036 ">10.1137/0222036
    </a>.
  short: H. Edelsbrunner, T. Tan, SIAM Journal on Computing 22 (1993) 527–551.
date_created: 2018-12-11T12:06:36Z
date_published: 1993-06-01T00:00:00Z
date_updated: 2022-03-30T07:43:13Z
day: '01'
doi: '10.1137/0222036 '
extern: '1'
intvolume: '        22'
issue: '3'
language:
- iso: eng
main_file_link:
- url: https://epubs.siam.org/doi/10.1137/0222036
month: '06'
oa_version: None
page: 527 - 551
publication: SIAM Journal on Computing
publication_identifier:
  issn:
  - 0097-5397
publication_status: published
publisher: SIAM
publist_id: '2086'
quality_controlled: '1'
scopus_import: '1'
status: public
title: A quadratic time algorithm for the minmax length triangulation
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 22
year: '1993'
...
---
_id: '4044'
abstract:
- lang: eng
  text: Edge insertion iteratively improves a triangulation of a finite point set
    in ℜ2 by adding a new edge, deleting old edges crossing the new edge, and retriangulating
    the polygonal regions on either side of the new edge. This paper presents an abstract
    view of the edge insertion paradigm, and then shows that it gives polynomial-time
    algorithms for several types of optimal triangulations, including minimizing the
    maximum slope of a piecewise-linear interpolating surface.
acknowledgement: "The authors thank two anonymous referees for suggestions on improving
  the style of this paper. The research of the second' author was supported by the
  National Science Foundation under Grant No. CCR-8921421 and under the Alan T. Waterman
  award, Grant No. CCR-9118874. Any opinions, findings, and conclusions or recommendations
  expressed in this publication are those of the authors and do not necessarily reflect
  the view of the National Science Foundation. Part of the work was done while the
  second, third, and fourth authors visited the Xerox Palo Alto Research Center,\r\nand
  while the fifth author was on study leave at the University of Illinois. "
article_processing_charge: No
article_type: original
author:
- first_name: Marshall
  full_name: Bern, Marshall
  last_name: Bern
- first_name: Herbert
  full_name: Edelsbrunner, Herbert
  id: 3FB178DA-F248-11E8-B48F-1D18A9856A87
  last_name: Edelsbrunner
  orcid: 0000-0002-9823-6833
- first_name: David
  full_name: Eppstein, David
  last_name: Eppstein
- first_name: Stephen
  full_name: Mitchell, Stephen
  last_name: Mitchell
- first_name: Tiow
  full_name: Tan, Tiow
  last_name: Tan
citation:
  ama: Bern M, Edelsbrunner H, Eppstein D, Mitchell S, Tan T. Edge insertion for optimal
    triangulations. <i>Discrete &#38; Computational Geometry</i>. 1993;10(1):47-65.
    doi:<a href="https://doi.org/10.1007/BF02573962">10.1007/BF02573962</a>
  apa: Bern, M., Edelsbrunner, H., Eppstein, D., Mitchell, S., &#38; Tan, T. (1993).
    Edge insertion for optimal triangulations. <i>Discrete &#38; Computational Geometry</i>.
    Springer. <a href="https://doi.org/10.1007/BF02573962">https://doi.org/10.1007/BF02573962</a>
  chicago: Bern, Marshall, Herbert Edelsbrunner, David Eppstein, Stephen Mitchell,
    and Tiow Tan. “Edge Insertion for Optimal Triangulations.” <i>Discrete &#38; Computational
    Geometry</i>. Springer, 1993. <a href="https://doi.org/10.1007/BF02573962">https://doi.org/10.1007/BF02573962</a>.
  ieee: M. Bern, H. Edelsbrunner, D. Eppstein, S. Mitchell, and T. Tan, “Edge insertion
    for optimal triangulations,” <i>Discrete &#38; Computational Geometry</i>, vol.
    10, no. 1. Springer, pp. 47–65, 1993.
  ista: Bern M, Edelsbrunner H, Eppstein D, Mitchell S, Tan T. 1993. Edge insertion
    for optimal triangulations. Discrete &#38; Computational Geometry. 10(1), 47–65.
  mla: Bern, Marshall, et al. “Edge Insertion for Optimal Triangulations.” <i>Discrete
    &#38; Computational Geometry</i>, vol. 10, no. 1, Springer, 1993, pp. 47–65, doi:<a
    href="https://doi.org/10.1007/BF02573962">10.1007/BF02573962</a>.
  short: M. Bern, H. Edelsbrunner, D. Eppstein, S. Mitchell, T. Tan, Discrete &#38;
    Computational Geometry 10 (1993) 47–65.
date_created: 2018-12-11T12:06:36Z
date_published: 1993-12-01T00:00:00Z
date_updated: 2022-03-28T14:10:59Z
day: '01'
doi: 10.1007/BF02573962
extern: '1'
intvolume: '        10'
issue: '1'
language:
- iso: eng
main_file_link:
- url: https://link.springer.com/article/10.1007/BF02573962
month: '12'
oa_version: None
page: 47 - 65
publication: Discrete & Computational Geometry
publication_identifier:
  issn:
  - 0179-5376
publication_status: published
publisher: Springer
publist_id: '2082'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Edge insertion for optimal triangulations
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 10
year: '1993'
...
---
_id: '4045'
abstract:
- lang: eng
  text: We apply Megiddo's parametric searching technique to several geometric optimization
    problems and derive significantly improved solutions for them. We obtain, for
    any fixed ε&gt;0, an O(n1+ε) algorithm for computing the diameter of a point set
    in 3-space, an O(8/5+ε) algorithm for computing the width of such a set, and on
    O(n8/5+ε) algorithm for computing the closest pair in a set of n lines in space.
    All these algorithms are deterministic.
acknowledgement: '*Work by Bernard Chazelle was supported by NSF Grant CCR-90-02352.
  Work by Herbert Edelsbrunner was supported by NSF Grant CCR-89-21421. Work by Leonidas
  Guibas and Micha Sharir was supported by a grant from the U.S.-Israeli Binational
  Science Foundation. Work by Micha Sharir was also supported by ONR Grant N00014-90-J-1284,
  by NSF Grant CCR-89-01484, and by grants from the Fund for Basic Research administered
  by the Israeli Academy of Sciences, and the G.I.F., the German-Israeli Foundation
  for Scientific Research and Development.'
article_processing_charge: No
article_type: original
author:
- first_name: Bernard
  full_name: Chazelle, Bernard
  last_name: Chazelle
- first_name: Herbert
  full_name: Edelsbrunner, Herbert
  id: 3FB178DA-F248-11E8-B48F-1D18A9856A87
  last_name: Edelsbrunner
  orcid: 0000-0002-9823-6833
- first_name: Leonidas
  full_name: Guibas, Leonidas
  last_name: Guibas
- first_name: Micha
  full_name: Sharir, Micha
  last_name: Sharir
citation:
  ama: Chazelle B, Edelsbrunner H, Guibas L, Sharir M. Diameter, width, closest line
    pair, and parametric searching. <i>Discrete &#38; Computational Geometry</i>.
    1993;10(1):183-196. doi:<a href="https://doi.org/10.1007/BF02573973">10.1007/BF02573973</a>
  apa: Chazelle, B., Edelsbrunner, H., Guibas, L., &#38; Sharir, M. (1993). Diameter,
    width, closest line pair, and parametric searching. <i>Discrete &#38; Computational
    Geometry</i>. Springer. <a href="https://doi.org/10.1007/BF02573973">https://doi.org/10.1007/BF02573973</a>
  chicago: Chazelle, Bernard, Herbert Edelsbrunner, Leonidas Guibas, and Micha Sharir.
    “Diameter, Width, Closest Line Pair, and Parametric Searching.” <i>Discrete &#38;
    Computational Geometry</i>. Springer, 1993. <a href="https://doi.org/10.1007/BF02573973">https://doi.org/10.1007/BF02573973</a>.
  ieee: B. Chazelle, H. Edelsbrunner, L. Guibas, and M. Sharir, “Diameter, width,
    closest line pair, and parametric searching,” <i>Discrete &#38; Computational
    Geometry</i>, vol. 10, no. 1. Springer, pp. 183–196, 1993.
  ista: Chazelle B, Edelsbrunner H, Guibas L, Sharir M. 1993. Diameter, width, closest
    line pair, and parametric searching. Discrete &#38; Computational Geometry. 10(1),
    183–196.
  mla: Chazelle, Bernard, et al. “Diameter, Width, Closest Line Pair, and Parametric
    Searching.” <i>Discrete &#38; Computational Geometry</i>, vol. 10, no. 1, Springer,
    1993, pp. 183–96, doi:<a href="https://doi.org/10.1007/BF02573973">10.1007/BF02573973</a>.
  short: B. Chazelle, H. Edelsbrunner, L. Guibas, M. Sharir, Discrete &#38; Computational
    Geometry 10 (1993) 183–196.
date_created: 2018-12-11T12:06:37Z
date_published: 1993-12-01T00:00:00Z
date_updated: 2022-03-28T14:50:42Z
day: '01'
doi: 10.1007/BF02573973
extern: '1'
intvolume: '        10'
issue: '1'
language:
- iso: eng
main_file_link:
- url: https://link.springer.com/article/10.1007/BF02573973
month: '12'
oa_version: None
page: 183 - 196
publication: Discrete & Computational Geometry
publication_identifier:
  issn:
  - 0179-5376
publication_status: published
publisher: Springer
publist_id: '2083'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Diameter, width, closest line pair, and parametric searching
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 10
year: '1993'
...
---
_id: '4175'
abstract:
- lang: eng
  text: We have studied the effects of different neurotrophins on the survival and
    proliferation of rat cerebellar granule cells in culture. These neurons express
    trkB and trkC, the putative neuronal receptors for brain-derived neurotrophic
    factor (BDNF) and neurotrophin-3 (NT-3) respectively. Binding studies using iodinated
    BDNF and NT-3 demonstrated that both BDNF and NT-3 bind to the cerebellar granule
    neurons with a similar affinity of approximately 2 x 10(-9) M. The number of receptors
    per granule cell was surprisingly high, approximately 30 x 10(-4) and 2 x 10(5)
    for BDNF and NT-3, respectively. Both NT-3 and BDNF elevated c-fos mRNA in the
    granule neurons, but only BDNF up-regulated the mRNA encoding the low-affinity
    neurotrophin receptor (p75). In contrast to NT-3, BDNF acted as a survival factor
    for the granule neurons. BDNF also induced sprouting of the granule neurons and
    significantly protected them against neurotoxicity induced by high (1 mM) glutamate
    concentrations. Cultured granule neurons also expressed low levels of BDNF mRNA
    which were increased by kainic acid, a glutamate receptor agonist. Thus, BDNF,
    but not NT-3, is a survival factor for cultured cerebellar granule neurons and
    activation of glutamate receptor(s) up-regulates BDNF expression in these cells.
article_processing_charge: No
article_type: original
author:
- first_name: Dan
  full_name: Lindholm, Dan
  last_name: Lindholm
- first_name: Georg
  full_name: Dechant, Georg
  last_name: Dechant
- first_name: Carl-Philipp J
  full_name: Heisenberg, Carl-Philipp J
  id: 39427864-F248-11E8-B48F-1D18A9856A87
  last_name: Heisenberg
  orcid: 0000-0002-0912-4566
- first_name: Hans
  full_name: Thoenen, Hans
  last_name: Thoenen
citation:
  ama: Lindholm D, Dechant G, Heisenberg C-PJ, Thoenen H. Brain-derived neurotrophic
    factor is a survival factor for cultured rat cerebellar granule neurons and protects
    them against glutamate-induced neurotoxicity. <i>European Journal of Neuroscience</i>.
    1993;5(11):1455-1464. doi:<a href="https://doi.org/10.1111/j.1460-9568.1993.tb00213.x">10.1111/j.1460-9568.1993.tb00213.x</a>
  apa: Lindholm, D., Dechant, G., Heisenberg, C.-P. J., &#38; Thoenen, H. (1993).
    Brain-derived neurotrophic factor is a survival factor for cultured rat cerebellar
    granule neurons and protects them against glutamate-induced neurotoxicity. <i>European
    Journal of Neuroscience</i>. Wiley-Blackwell. <a href="https://doi.org/10.1111/j.1460-9568.1993.tb00213.x">https://doi.org/10.1111/j.1460-9568.1993.tb00213.x</a>
  chicago: Lindholm, Dan, Georg Dechant, Carl-Philipp J Heisenberg, and Hans Thoenen.
    “Brain-Derived Neurotrophic Factor Is a Survival Factor for Cultured Rat Cerebellar
    Granule Neurons and Protects Them against Glutamate-Induced Neurotoxicity.” <i>European
    Journal of Neuroscience</i>. Wiley-Blackwell, 1993. <a href="https://doi.org/10.1111/j.1460-9568.1993.tb00213.x">https://doi.org/10.1111/j.1460-9568.1993.tb00213.x</a>.
  ieee: D. Lindholm, G. Dechant, C.-P. J. Heisenberg, and H. Thoenen, “Brain-derived
    neurotrophic factor is a survival factor for cultured rat cerebellar granule neurons
    and protects them against glutamate-induced neurotoxicity,” <i>European Journal
    of Neuroscience</i>, vol. 5, no. 11. Wiley-Blackwell, pp. 1455–1464, 1993.
  ista: Lindholm D, Dechant G, Heisenberg C-PJ, Thoenen H. 1993. Brain-derived neurotrophic
    factor is a survival factor for cultured rat cerebellar granule neurons and protects
    them against glutamate-induced neurotoxicity. European Journal of Neuroscience.
    5(11), 1455–1464.
  mla: Lindholm, Dan, et al. “Brain-Derived Neurotrophic Factor Is a Survival Factor
    for Cultured Rat Cerebellar Granule Neurons and Protects Them against Glutamate-Induced
    Neurotoxicity.” <i>European Journal of Neuroscience</i>, vol. 5, no. 11, Wiley-Blackwell,
    1993, pp. 1455–64, doi:<a href="https://doi.org/10.1111/j.1460-9568.1993.tb00213.x">10.1111/j.1460-9568.1993.tb00213.x</a>.
  short: D. Lindholm, G. Dechant, C.-P.J. Heisenberg, H. Thoenen, European Journal
    of Neuroscience 5 (1993) 1455–1464.
date_created: 2018-12-11T12:07:24Z
date_published: 1993-11-01T00:00:00Z
date_updated: 2022-03-28T13:33:18Z
day: '01'
doi: 10.1111/j.1460-9568.1993.tb00213.x
extern: '1'
external_id:
  pmid:
  - '7904521 '
intvolume: '         5'
issue: '11'
language:
- iso: eng
main_file_link:
- url: https://onlinelibrary.wiley.com/doi/10.1111/j.1460-9568.1993.tb00213.x
month: '11'
oa_version: None
page: 1455 - 1464
pmid: 1
publication: European Journal of Neuroscience
publication_identifier:
  issn:
  - 0953-816X
publication_status: published
publisher: Wiley-Blackwell
publist_id: '1943'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Brain-derived neurotrophic factor is a survival factor for cultured rat cerebellar
  granule neurons and protects them against glutamate-induced neurotoxicity
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 5
year: '1993'
...
---
_id: '4177'
abstract:
- lang: eng
  text: Thyroid hormones play an important role in brain development, but the mechanism(s)
    by which triiodothyronine (T3) mediates neuronal differentiation is poorly understood.
    Here we demonstrate that T3 regulates the neurotrophic factor, neurotrophin-3
    (NT-3), in developing rat cerebellar granule cells both in cell culture and in
    vivo. In situ hybridization experiments showed that developing Purkinje cells
    do not express NT-3 mRNA but do express trkC, the putative neuronal receptor for
    NT-3. Addition of recombinant NT-3 to cerebellar cultures from embryonic rat brain
    induces hypertrophy and neurite sprouting of Purkinje cells, and upregulates the
    mRNA encoding the calcium-binding protein, calbindin-28 kD. The present study
    demonstrates a novel interaction between cerebellar granule neurons and developing
    Purkinje cells in which NT-3 induced by T3 in the granule cells promotes Purkinje
    cell differentiation.
acknowledgement: "E. Castrtn is an Alexander von Humboldt fellow. M. Berzaghi is supported
  by a scholarship from CNPQ, Brasil. L. F. Parada, P. Tsoulfas, and L. Tesarollo
  were supported by a National Institutes of Health grant. We thank D. Stratmann and
  K. Angermeyer for skillful technical assistance; I. Hajjar for secretarial work
  and Dr. R. G~rtner for help with\r\ninducing hypothyroidism; Dr. W. Hunzieker for
  the calbindin-28 kD eDNA; Dr. M. Fishman for the GAP-43 eDNA; and Dr. Y.-A. Barde
  for critical comments."
article_processing_charge: No
article_type: original
author:
- first_name: Dan
  full_name: Lindholm, Dan
  last_name: Lindholm
- first_name: Eero
  full_name: Castrén, Eero
  last_name: Castrén
- first_name: Pantelis
  full_name: Tsoulfas, Pantelis
  last_name: Tsoulfas
- first_name: Roland
  full_name: Kolbeck, Roland
  last_name: Kolbeck
- first_name: Maria
  full_name: Berzaghi, Maria
  last_name: Berzaghi
- first_name: Axel
  full_name: Leingärtner, Axel
  last_name: Leingärtner
- first_name: Carl-Philipp J
  full_name: Heisenberg, Carl-Philipp J
  id: 39427864-F248-11E8-B48F-1D18A9856A87
  last_name: Heisenberg
  orcid: 0000-0002-0912-4566
- first_name: Lino
  full_name: Tesarollo, Lino
  last_name: Tesarollo
- first_name: Luis
  full_name: Parada, Luis
  last_name: Parada
- first_name: Hans
  full_name: Thoenen, Hans
  last_name: Thoenen
citation:
  ama: Lindholm D, Castrén E, Tsoulfas P, et al. Neurotrophin-3 induced by tri-iodothyronine
    in cerebellar granule cells promotes Purkinje cell differentiation. <i>Journal
    of Cell Biology</i>. 1993;122(2):443-450. doi:<a href="https://doi.org/10.1083/jcb.122.2.443">10.1083/jcb.122.2.443</a>
  apa: Lindholm, D., Castrén, E., Tsoulfas, P., Kolbeck, R., Berzaghi, M., Leingärtner,
    A., … Thoenen, H. (1993). Neurotrophin-3 induced by tri-iodothyronine in cerebellar
    granule cells promotes Purkinje cell differentiation. <i>Journal of Cell Biology</i>.
    Rockefeller University Press. <a href="https://doi.org/10.1083/jcb.122.2.443">https://doi.org/10.1083/jcb.122.2.443</a>
  chicago: Lindholm, Dan, Eero Castrén, Pantelis Tsoulfas, Roland Kolbeck, Maria Berzaghi,
    Axel Leingärtner, Carl-Philipp J Heisenberg, Lino Tesarollo, Luis Parada, and
    Hans Thoenen. “Neurotrophin-3 Induced by Tri-Iodothyronine in Cerebellar Granule
    Cells Promotes Purkinje Cell Differentiation.” <i>Journal of Cell Biology</i>.
    Rockefeller University Press, 1993. <a href="https://doi.org/10.1083/jcb.122.2.443">https://doi.org/10.1083/jcb.122.2.443</a>.
  ieee: D. Lindholm <i>et al.</i>, “Neurotrophin-3 induced by tri-iodothyronine in
    cerebellar granule cells promotes Purkinje cell differentiation,” <i>Journal of
    Cell Biology</i>, vol. 122, no. 2. Rockefeller University Press, pp. 443–450,
    1993.
  ista: Lindholm D, Castrén E, Tsoulfas P, Kolbeck R, Berzaghi M, Leingärtner A, Heisenberg
    C-PJ, Tesarollo L, Parada L, Thoenen H. 1993. Neurotrophin-3 induced by tri-iodothyronine
    in cerebellar granule cells promotes Purkinje cell differentiation. Journal of
    Cell Biology. 122(2), 443–450.
  mla: Lindholm, Dan, et al. “Neurotrophin-3 Induced by Tri-Iodothyronine in Cerebellar
    Granule Cells Promotes Purkinje Cell Differentiation.” <i>Journal of Cell Biology</i>,
    vol. 122, no. 2, Rockefeller University Press, 1993, pp. 443–50, doi:<a href="https://doi.org/10.1083/jcb.122.2.443">10.1083/jcb.122.2.443</a>.
  short: D. Lindholm, E. Castrén, P. Tsoulfas, R. Kolbeck, M. Berzaghi, A. Leingärtner,
    C.-P.J. Heisenberg, L. Tesarollo, L. Parada, H. Thoenen, Journal of Cell Biology
    122 (1993) 443–450.
date_created: 2018-12-11T12:07:25Z
date_published: 1993-07-15T00:00:00Z
date_updated: 2022-03-24T12:59:20Z
day: '15'
doi: 10.1083/jcb.122.2.443
extern: '1'
external_id:
  pmid:
  - '8320266'
intvolume: '       122'
issue: '2'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2119654/
month: '07'
oa: 1
oa_version: None
page: 443 - 450
pmid: 1
publication: Journal of Cell Biology
publication_identifier:
  issn:
  - 0021-9525
publication_status: published
publisher: Rockefeller University Press
publist_id: '1942'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Neurotrophin-3 induced by tri-iodothyronine in cerebellar granule cells promotes
  Purkinje cell differentiation
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 122
year: '1993'
...
---
_id: '4299'
abstract:
- lang: eng
  text: Evolutionary explanations of aging (or senescence) fall into two classes.
    First, organisms might have evolved the optimal life history, in which survival
    and fertility late in life are sacrificed for the sake of early reproduction or
    high pre-adult survival. Second, the life history might be depressed below this
    optimal compromise by the influx of deleterious mutations; since selection against
    late-acting mutations is weaker, deleterious mutations will impose a greater load
    on late life. We discuss ways in which these theories might be investigated and
    distinguished, with reference to experimental work withDrosophila. While genetic
    correlations between life history traits determine the immediate response to selection,
    they are hard to measure, and may not reflect the fundamental constraints on life
    history. Long term selection experiments are more likely to be informative. The
    third approach of using experimental manipulations suffers from some of the same
    problems as measures of genetic correlations; however, these two approaches may
    be fruitful when used together. The experimental results so far suggest that aging
    inDrosophila has evolved in part as a consequence of selection for an optimal
    life history, and in part as a result of accumulation of predominantly late-acting
    deleterious mutations. Quantification of these effects presents a major challenge
    for the future.
article_processing_charge: No
article_type: original
author:
- first_name: Linda
  full_name: Partridge, Linda
  last_name: Partridge
- first_name: Nicholas H
  full_name: Barton, Nicholas H
  id: 4880FE40-F248-11E8-B48F-1D18A9856A87
  last_name: Barton
  orcid: 0000-0002-8548-5240
citation:
  ama: 'Partridge L, Barton NH. Evolution of aging: Testing the theory using Drosophila.
    <i>Genetica</i>. 1993;91(1-3):89-98. doi:<a href="https://doi.org/10.1007/BF01435990">10.1007/BF01435990</a>'
  apa: 'Partridge, L., &#38; Barton, N. H. (1993). Evolution of aging: Testing the
    theory using Drosophila. <i>Genetica</i>. Springer. <a href="https://doi.org/10.1007/BF01435990">https://doi.org/10.1007/BF01435990</a>'
  chicago: 'Partridge, Linda, and Nicholas H Barton. “Evolution of Aging: Testing
    the Theory Using Drosophila.” <i>Genetica</i>. Springer, 1993. <a href="https://doi.org/10.1007/BF01435990">https://doi.org/10.1007/BF01435990</a>.'
  ieee: 'L. Partridge and N. H. Barton, “Evolution of aging: Testing the theory using
    Drosophila,” <i>Genetica</i>, vol. 91, no. 1–3. Springer, pp. 89–98, 1993.'
  ista: 'Partridge L, Barton NH. 1993. Evolution of aging: Testing the theory using
    Drosophila. Genetica. 91(1–3), 89–98.'
  mla: 'Partridge, Linda, and Nicholas H. Barton. “Evolution of Aging: Testing the
    Theory Using Drosophila.” <i>Genetica</i>, vol. 91, no. 1–3, Springer, 1993, pp.
    89–98, doi:<a href="https://doi.org/10.1007/BF01435990">10.1007/BF01435990</a>.'
  short: L. Partridge, N.H. Barton, Genetica 91 (1993) 89–98.
date_created: 2018-12-11T12:08:07Z
date_published: 1993-01-01T00:00:00Z
date_updated: 2022-06-02T10:00:56Z
day: '01'
doi: 10.1007/BF01435990
extern: '1'
external_id:
  pmid:
  - '8125281 '
intvolume: '        91'
issue: 1-3
language:
- iso: eng
main_file_link:
- url: https://link.springer.com/article/10.1007/BF01435990
month: '01'
oa_version: None
page: 89 - 98
pmid: 1
publication: Genetica
publication_identifier:
  issn:
  - 0016-6707
publication_status: published
publisher: Springer
publist_id: '1769'
quality_controlled: '1'
scopus_import: '1'
status: public
title: 'Evolution of aging: Testing the theory using Drosophila'
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 91
year: '1993'
...
---
_id: '4300'
abstract:
- lang: eng
  text: 'Evolutionary explanations of ageing fall into two classes. Organisms might
    have evolved the optimal life history, in which survival and fertility late in
    life are sacrificed for the sake of early reproduction and survival. Alternatively,
    the life history might be depressed below this optimal compromise by deleterious
    mutations: because selection against late-acting mutations is weaker, these will
    impose a greater load on late life. Evidence for the importance of both is emerging,
    and unravelling their relative importance presents experimentalists with a major
    challenge.'
acknowledgement: We thank B. Charlesworth, T. Chapman. K. Dawson, K. S. Gale. P. Harvey.
  A. Kondrashov. J. Maynard Smith, M. J. Morgan, M. Slatkin and M. Turell/ for helpful
  comments and C. Roper for providing the data for Fig. 1. Our work was supported
  by grants from the NERC and SERC and by the Darwin Trust of Edinburgh.
article_processing_charge: No
article_type: original
author:
- first_name: Linda
  full_name: Partridge, Linda
  last_name: Partridge
- first_name: Nicholas H
  full_name: Barton, Nicholas H
  id: 4880FE40-F248-11E8-B48F-1D18A9856A87
  last_name: Barton
  orcid: 0000-0002-8548-5240
citation:
  ama: Partridge L, Barton NH. Optimality, mutation and the evolution of ageing. <i>Nature</i>.
    1993;362:305-311. doi:<a href="https://doi.org/10.1038/362305a0">10.1038/362305a0</a>
  apa: Partridge, L., &#38; Barton, N. H. (1993). Optimality, mutation and the evolution
    of ageing. <i>Nature</i>. Nature Publishing Group. <a href="https://doi.org/10.1038/362305a0">https://doi.org/10.1038/362305a0</a>
  chicago: Partridge, Linda, and Nicholas H Barton. “Optimality, Mutation and the
    Evolution of Ageing.” <i>Nature</i>. Nature Publishing Group, 1993. <a href="https://doi.org/10.1038/362305a0">https://doi.org/10.1038/362305a0</a>.
  ieee: L. Partridge and N. H. Barton, “Optimality, mutation and the evolution of
    ageing,” <i>Nature</i>, vol. 362. Nature Publishing Group, pp. 305–311, 1993.
  ista: Partridge L, Barton NH. 1993. Optimality, mutation and the evolution of ageing.
    Nature. 362, 305–311.
  mla: Partridge, Linda, and Nicholas H. Barton. “Optimality, Mutation and the Evolution
    of Ageing.” <i>Nature</i>, vol. 362, Nature Publishing Group, 1993, pp. 305–11,
    doi:<a href="https://doi.org/10.1038/362305a0">10.1038/362305a0</a>.
  short: L. Partridge, N.H. Barton, Nature 362 (1993) 305–311.
date_created: 2018-12-11T12:08:07Z
date_published: 1993-03-25T00:00:00Z
date_updated: 2022-03-24T12:22:38Z
day: '25'
doi: 10.1038/362305a0
extern: '1'
external_id:
  pmid:
  - '8455716'
intvolume: '       362'
language:
- iso: eng
main_file_link:
- url: https://www.nature.com/articles/362305a0
month: '03'
oa_version: None
page: 305 - 311
pmid: 1
publication: Nature
publication_identifier:
  issn:
  - 0028-0836
publication_status: published
publisher: Nature Publishing Group
publist_id: '1766'
quality_controlled: '1'
status: public
title: Optimality, mutation and the evolution of ageing
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 362
year: '1993'
...
---
_id: '4301'
article_processing_charge: No
author:
- first_name: Nicholas H
  full_name: Barton, Nicholas H
  id: 4880FE40-F248-11E8-B48F-1D18A9856A87
  last_name: Barton
  orcid: 0000-0002-8548-5240
- first_name: Katherine
  full_name: Gale, Katherine
  last_name: Gale
citation:
  ama: 'Barton NH, Gale K. Genetic analysis of hybrid zones. In: Harrison R, ed. <i>Hybrid
    Zones and the Evolutionary Process</i>. Oxford University Press; 1993:13-45. doi:<a
    href="https://doi.org/10.1046/j.1420-9101.1994.7050631.x">10.1046/j.1420-9101.1994.7050631.x</a>'
  apa: Barton, N. H., &#38; Gale, K. (1993). Genetic analysis of hybrid zones. In
    R. Harrison (Ed.), <i>Hybrid zones and the evolutionary process</i> (pp. 13–45).
    Oxford University Press. <a href="https://doi.org/10.1046/j.1420-9101.1994.7050631.x">https://doi.org/10.1046/j.1420-9101.1994.7050631.x</a>
  chicago: Barton, Nicholas H, and Katherine Gale. “Genetic Analysis of Hybrid Zones.”
    In <i>Hybrid Zones and the Evolutionary Process</i>, edited by Richard Harrison,
    13–45. Oxford University Press, 1993. <a href="https://doi.org/10.1046/j.1420-9101.1994.7050631.x">https://doi.org/10.1046/j.1420-9101.1994.7050631.x</a>.
  ieee: N. H. Barton and K. Gale, “Genetic analysis of hybrid zones,” in <i>Hybrid
    zones and the evolutionary process</i>, R. Harrison, Ed. Oxford University Press,
    1993, pp. 13–45.
  ista: 'Barton NH, Gale K. 1993.Genetic analysis of hybrid zones. In: Hybrid zones
    and the evolutionary process. , 13–45.'
  mla: Barton, Nicholas H., and Katherine Gale. “Genetic Analysis of Hybrid Zones.”
    <i>Hybrid Zones and the Evolutionary Process</i>, edited by Richard Harrison,
    Oxford University Press, 1993, pp. 13–45, doi:<a href="https://doi.org/10.1046/j.1420-9101.1994.7050631.x">10.1046/j.1420-9101.1994.7050631.x</a>.
  short: N.H. Barton, K. Gale, in:, R. Harrison (Ed.), Hybrid Zones and the Evolutionary
    Process, Oxford University Press, 1993, pp. 13–45.
date_created: 2018-12-11T12:08:08Z
date_published: 1993-01-01T00:00:00Z
date_updated: 2022-03-24T10:36:10Z
day: '01'
doi: 10.1046/j.1420-9101.1994.7050631.x
editor:
- first_name: Richard
  full_name: Harrison, Richard
  last_name: Harrison
extern: '1'
language:
- iso: eng
main_file_link:
- url: https://books.google.at/books?hl=en&lr=&id=aFJFkVKskYIC&oi=fnd&pg=PA13&ots=MFf0ehNeKK&sig=Yp6VrwzCJRB-v-iOhI7WZw-xf8w&redir_esc=y#v=onepage&q&f=false
month: '01'
oa_version: None
page: 13 - 45
publication: Hybrid zones and the evolutionary process
publication_identifier:
  isbn:
  - ' 0-19-506917-X'
publication_status: published
publisher: Oxford University Press
publist_id: '1764'
quality_controlled: '1'
status: public
title: Genetic analysis of hybrid zones
type: book_chapter
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
year: '1993'
...
