---
_id: '2546'
abstract:
- lang: eng
  text: 'Immunochemical characteristics of neostriatal neurons producing substance
    P receptor (SPR) were examined in adult rats by double- and triple-immunofluorescence
    methods. In the neostriatum, SPR immunoreactivity was detected in large and medium-sized
    aspiny neurons. Virtually all SPR-immunoreactive neurons in the neostriatum contained
    somatostatin (SS) or choline acetyltransferase (ChAT), but not parvalbumin. All
    SS- and ChAT-immunoreactive neurons in the neostriatum showed SPR immunoreactivity.
    The co-existence of SS and ChAT was, however, not found in single neurons expressing
    SPR immunoreactivity. The present results indicate that neostriatal neurons immunoreactive
    for SPR are segregated into 2 groups: (1) medium-sized, aspiny somatostatinergic,
    and (2) large, aspiny cholinergic neurons.'
article_processing_charge: No
article_type: original
author:
- first_name: Takeshi
  full_name: Kaneko, Takeshi
  last_name: Kaneko
- first_name: Ryuichi
  full_name: Shigemoto, Ryuichi
  id: 499F3ABC-F248-11E8-B48F-1D18A9856A87
  last_name: Shigemoto
  orcid: 0000-0001-8761-9444
- first_name: Shigetada
  full_name: Nakanishi, Shigetada
  last_name: Nakanishi
- first_name: Noboru
  full_name: Mizuno, Noboru
  last_name: Mizuno
citation:
  ama: Kaneko T, Shigemoto R, Nakanishi S, Mizuno N. Substance P receptor-immunoreactive
    neurons in the rat neostriatum are segregated into somatostatinergic and cholinergic
    aspiny neurons. <i>Brain Research</i>. 1993;631(2):297-303. doi:<a href="https://doi.org/10.1016/0006-8993(93)91548-7">10.1016/0006-8993(93)91548-7</a>
  apa: Kaneko, T., Shigemoto, R., Nakanishi, S., &#38; Mizuno, N. (1993). Substance
    P receptor-immunoreactive neurons in the rat neostriatum are segregated into somatostatinergic
    and cholinergic aspiny neurons. <i>Brain Research</i>. Elsevier. <a href="https://doi.org/10.1016/0006-8993(93)91548-7">https://doi.org/10.1016/0006-8993(93)91548-7</a>
  chicago: Kaneko, Takeshi, Ryuichi Shigemoto, Shigetada Nakanishi, and Noboru Mizuno.
    “Substance P Receptor-Immunoreactive Neurons in the Rat Neostriatum Are Segregated
    into Somatostatinergic and Cholinergic Aspiny Neurons.” <i>Brain Research</i>.
    Elsevier, 1993. <a href="https://doi.org/10.1016/0006-8993(93)91548-7">https://doi.org/10.1016/0006-8993(93)91548-7</a>.
  ieee: T. Kaneko, R. Shigemoto, S. Nakanishi, and N. Mizuno, “Substance P receptor-immunoreactive
    neurons in the rat neostriatum are segregated into somatostatinergic and cholinergic
    aspiny neurons,” <i>Brain Research</i>, vol. 631, no. 2. Elsevier, pp. 297–303,
    1993.
  ista: Kaneko T, Shigemoto R, Nakanishi S, Mizuno N. 1993. Substance P receptor-immunoreactive
    neurons in the rat neostriatum are segregated into somatostatinergic and cholinergic
    aspiny neurons. Brain Research. 631(2), 297–303.
  mla: Kaneko, Takeshi, et al. “Substance P Receptor-Immunoreactive Neurons in the
    Rat Neostriatum Are Segregated into Somatostatinergic and Cholinergic Aspiny Neurons.”
    <i>Brain Research</i>, vol. 631, no. 2, Elsevier, 1993, pp. 297–303, doi:<a href="https://doi.org/10.1016/0006-8993(93)91548-7">10.1016/0006-8993(93)91548-7</a>.
  short: T. Kaneko, R. Shigemoto, S. Nakanishi, N. Mizuno, Brain Research 631 (1993)
    297–303.
date_created: 2018-12-11T11:58:18Z
date_published: 1993-12-24T00:00:00Z
date_updated: 2022-03-31T09:14:23Z
day: '24'
doi: 10.1016/0006-8993(93)91548-7
extern: '1'
external_id:
  pmid:
  - '7907524'
intvolume: '       631'
issue: '2'
language:
- iso: eng
main_file_link:
- url: https://www.sciencedirect.com/science/article/pii/0006899393915487?via%3Dihub
month: '12'
oa_version: None
page: 297 - 303
pmid: 1
publication: Brain Research
publication_identifier:
  issn:
  - 0006-8993
publication_status: published
publisher: Elsevier
publist_id: '4353'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Substance P receptor-immunoreactive neurons in the rat neostriatum are segregated
  into somatostatinergic and cholinergic aspiny neurons
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 631
year: '1993'
...
---
_id: '2723'
abstract:
- lang: eng
  text: 'The ground-state density of the Pauli operator in the case of a nonconstant
    magnetic field with constant direction is studied. It is shown that in the large
    field limit, the naturally rescaled ground-state density function is bounded from
    above by the megnetic field, and under some additional conditions, the limit density
    function is equal to the magnetic field. A restatement of this result yields an
    estimate on the density of complex orthogonal polynomials with respect to a fairly
    general weight function. We also prove a special case of the paramagnetic inequality. '
article_processing_charge: No
article_type: original
author:
- first_name: László
  full_name: Erdös, László
  id: 4DBD5372-F248-11E8-B48F-1D18A9856A87
  last_name: Erdös
  orcid: 0000-0001-5366-9603
citation:
  ama: Erdös L. Ground-state density of the Pauli operator in the large field limit.
    <i>Letters in Mathematical Physics</i>. 1993;29(3):219-240. doi:<a href="https://doi.org/10.1007/BF00761110">10.1007/BF00761110</a>
  apa: Erdös, L. (1993). Ground-state density of the Pauli operator in the large field
    limit. <i>Letters in Mathematical Physics</i>. Springer. <a href="https://doi.org/10.1007/BF00761110">https://doi.org/10.1007/BF00761110</a>
  chicago: Erdös, László. “Ground-State Density of the Pauli Operator in the Large
    Field Limit.” <i>Letters in Mathematical Physics</i>. Springer, 1993. <a href="https://doi.org/10.1007/BF00761110">https://doi.org/10.1007/BF00761110</a>.
  ieee: L. Erdös, “Ground-state density of the Pauli operator in the large field limit,”
    <i>Letters in Mathematical Physics</i>, vol. 29, no. 3. Springer, pp. 219–240,
    1993.
  ista: Erdös L. 1993. Ground-state density of the Pauli operator in the large field
    limit. Letters in Mathematical Physics. 29(3), 219–240.
  mla: Erdös, László. “Ground-State Density of the Pauli Operator in the Large Field
    Limit.” <i>Letters in Mathematical Physics</i>, vol. 29, no. 3, Springer, 1993,
    pp. 219–40, doi:<a href="https://doi.org/10.1007/BF00761110">10.1007/BF00761110</a>.
  short: L. Erdös, Letters in Mathematical Physics 29 (1993) 219–240.
date_created: 2018-12-11T11:59:16Z
date_published: 1993-11-01T00:00:00Z
date_updated: 2022-03-30T15:02:00Z
day: '01'
doi: 10.1007/BF00761110
extern: '1'
intvolume: '        29'
issue: '3'
language:
- iso: eng
main_file_link:
- url: https://link.springer.com/article/10.1007/BF00761110
month: '11'
oa_version: None
page: 219 - 240
publication: Letters in Mathematical Physics
publication_identifier:
  issn:
  - 0377-9017
publication_status: published
publisher: Springer
publist_id: '4169'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Ground-state density of the Pauli operator in the large field limit
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 29
year: '1993'
...
---
_id: '1947'
abstract:
- lang: eng
  text: Mitochondrial transhydrogenase has been reported previously to be inhibited
    by high, rather non-physiological concentrations (in the range of 2-20 mM) of
    divalent cations. We show that the enzyme could be activated by low (from about
    1 μM to 1 mM) concentrations of Ca2+ and Mg2+, which are within physiological
    range. These results bring in line the effects observed with mitochondrial enzyme
    to the findings with bacterial transhydrogenases. The activation of transhydrogenase
    by divalent cations is interpreted as an increase in affinity of the NADP(H)-binding
    site of the enzyme-NAD(H) complex. Reported effects of the metal ions could be
    important for the enzyme function in vivo.
acknowledgement: 'This work was supported by a Wellcome Trust fellowship to L.A.S. '
article_processing_charge: No
article_type: original
author:
- first_name: Leonid A
  full_name: Sazanov, Leonid A
  id: 338D39FE-F248-11E8-B48F-1D18A9856A87
  last_name: Sazanov
  orcid: 0000-0002-0977-7989
- first_name: Julie
  full_name: Jackson, Julie
  last_name: Jackson
citation:
  ama: Sazanov LA, Jackson J. Activation and inhibition of mitochondrial transhydrogenase
    by metal ions. <i>Biochimica et Biophysica Acta - Bioenergetics</i>. 1993;1144(2):225-228.
    doi:<a href="https://doi.org/10.1016/0005-2728(93)90177-H">10.1016/0005-2728(93)90177-H</a>
  apa: Sazanov, L. A., &#38; Jackson, J. (1993). Activation and inhibition of mitochondrial
    transhydrogenase by metal ions. <i>Biochimica et Biophysica Acta - Bioenergetics</i>.
    Elsevier. <a href="https://doi.org/10.1016/0005-2728(93)90177-H">https://doi.org/10.1016/0005-2728(93)90177-H</a>
  chicago: Sazanov, Leonid A, and Julie Jackson. “Activation and Inhibition of Mitochondrial
    Transhydrogenase by Metal Ions.” <i>Biochimica et Biophysica Acta - Bioenergetics</i>.
    Elsevier, 1993. <a href="https://doi.org/10.1016/0005-2728(93)90177-H">https://doi.org/10.1016/0005-2728(93)90177-H</a>.
  ieee: L. A. Sazanov and J. Jackson, “Activation and inhibition of mitochondrial
    transhydrogenase by metal ions,” <i>Biochimica et Biophysica Acta - Bioenergetics</i>,
    vol. 1144, no. 2. Elsevier, pp. 225–228, 1993.
  ista: Sazanov LA, Jackson J. 1993. Activation and inhibition of mitochondrial transhydrogenase
    by metal ions. Biochimica et Biophysica Acta - Bioenergetics. 1144(2), 225–228.
  mla: Sazanov, Leonid A., and Julie Jackson. “Activation and Inhibition of Mitochondrial
    Transhydrogenase by Metal Ions.” <i>Biochimica et Biophysica Acta - Bioenergetics</i>,
    vol. 1144, no. 2, Elsevier, 1993, pp. 225–28, doi:<a href="https://doi.org/10.1016/0005-2728(93)90177-H">10.1016/0005-2728(93)90177-H</a>.
  short: L.A. Sazanov, J. Jackson, Biochimica et Biophysica Acta - Bioenergetics 1144
    (1993) 225–228.
date_created: 2018-12-11T11:54:52Z
date_published: 1993-09-13T00:00:00Z
date_updated: 2022-06-01T12:51:32Z
day: '13'
doi: 10.1016/0005-2728(93)90177-H
extern: '1'
external_id:
  pmid:
  - '8369341 '
intvolume: '      1144'
issue: '2'
language:
- iso: eng
main_file_link:
- url: https://www.sciencedirect.com/science/article/pii/000527289390177H?via%3Dihub
month: '09'
oa_version: None
page: 225 - 228
pmid: 1
publication: Biochimica et Biophysica Acta - Bioenergetics
publication_identifier:
  issn:
  - 0005-2728
publication_status: published
publisher: Elsevier
publist_id: '5136'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Activation and inhibition of mitochondrial transhydrogenase by metal ions
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 1144
year: '1993'
...
---
_id: '1948'
acknowledgement: 'We acknowledge financial support from the Wellcome Trust (fellowship
  to L.A.S) '
article_processing_charge: No
article_type: original
author:
- first_name: Leonid A
  full_name: Sazanov, Leonid A
  id: 338D39FE-F248-11E8-B48F-1D18A9856A87
  last_name: Sazanov
  orcid: 0000-0002-0977-7989
- first_name: Julie
  full_name: Jackson, Julie
  last_name: Jackson
citation:
  ama: Sazanov LA, Jackson J. Possible functions of the NADP-linked isocitrate dehydrogenase
    and H+ -transhydrogenase in heart mitochondria . <i>Biochemical Society Transactions</i>.
    1993;21(3):260. doi:<a href="https://doi.org/10.1042/bst021260s">10.1042/bst021260s</a>
  apa: Sazanov, L. A., &#38; Jackson, J. (1993). Possible functions of the NADP-linked
    isocitrate dehydrogenase and H+ -transhydrogenase in heart mitochondria . <i>Biochemical
    Society Transactions</i>. Portland Press. <a href="https://doi.org/10.1042/bst021260s">https://doi.org/10.1042/bst021260s</a>
  chicago: Sazanov, Leonid A, and Julie Jackson. “Possible Functions of the NADP-Linked
    Isocitrate Dehydrogenase and H+ -Transhydrogenase in Heart Mitochondria .” <i>Biochemical
    Society Transactions</i>. Portland Press, 1993. <a href="https://doi.org/10.1042/bst021260s">https://doi.org/10.1042/bst021260s</a>.
  ieee: L. A. Sazanov and J. Jackson, “Possible functions of the NADP-linked isocitrate
    dehydrogenase and H+ -transhydrogenase in heart mitochondria ,” <i>Biochemical
    Society Transactions</i>, vol. 21, no. 3. Portland Press, p. 260, 1993.
  ista: Sazanov LA, Jackson J. 1993. Possible functions of the NADP-linked isocitrate
    dehydrogenase and H+ -transhydrogenase in heart mitochondria . Biochemical Society
    Transactions. 21(3), 260.
  mla: Sazanov, Leonid A., and Julie Jackson. “Possible Functions of the NADP-Linked
    Isocitrate Dehydrogenase and H+ -Transhydrogenase in Heart Mitochondria .” <i>Biochemical
    Society Transactions</i>, vol. 21, no. 3, Portland Press, 1993, p. 260, doi:<a
    href="https://doi.org/10.1042/bst021260s">10.1042/bst021260s</a>.
  short: L.A. Sazanov, J. Jackson, Biochemical Society Transactions 21 (1993) 260.
date_created: 2018-12-11T11:54:52Z
date_published: 1993-01-01T00:00:00Z
date_updated: 2022-06-01T13:17:02Z
day: '01'
doi: 10.1042/bst021260s
extern: '1'
external_id:
  pmid:
  - '8224412 '
intvolume: '        21'
issue: '3'
language:
- iso: eng
main_file_link:
- url: https://portlandpress.com/biochemsoctrans/article-abstract/21/3/260S/83260/Possible-functions-of-the-NADP-linked-isocitrate?redirectedFrom=fulltext
month: '01'
oa_version: None
page: '260'
pmid: 1
publication: Biochemical Society Transactions
publication_identifier:
  issn:
  - 0300-5127
publication_status: published
publisher: Portland Press
publist_id: '5137'
quality_controlled: '1'
scopus_import: '1'
status: public
title: 'Possible functions of the NADP-linked isocitrate dehydrogenase and H+ -transhydrogenase
  in heart mitochondria '
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 21
year: '1993'
...
---
_id: '1950'
article_processing_charge: No
article_type: original
author:
- first_name: Julie
  full_name: Jackson, Julie
  last_name: Jackson
- first_name: N P J
  full_name: Cotton, N P J
  last_name: Cotton
- first_name: Ross
  full_name: Williams, Ross
  last_name: Williams
- first_name: Tania
  full_name: Bizouarn, Tania
  last_name: Bizouarn
- first_name: Mike
  full_name: Hutton, Mike
  last_name: Hutton
- first_name: Leonid A
  full_name: Sazanov, Leonid A
  id: 338D39FE-F248-11E8-B48F-1D18A9856A87
  last_name: Sazanov
  orcid: 0000-0002-0977-7989
- first_name: Christopher
  full_name: Thomas, Christopher
  last_name: Thomas
citation:
  ama: Jackson J, Cotton NPJ, Williams R, et al. Proton-translocating transhydrogenase
    in bacteria. <i>Biochemical Society Transactions</i>. 1993;21(4):1010-1013. doi:<a
    href="https://doi.org/10.1042/bst0211010">10.1042/bst0211010</a>
  apa: Jackson, J., Cotton, N. P. J., Williams, R., Bizouarn, T., Hutton, M., Sazanov,
    L. A., &#38; Thomas, C. (1993). Proton-translocating transhydrogenase in bacteria.
    <i>Biochemical Society Transactions</i>. Portland Press. <a href="https://doi.org/10.1042/bst0211010">https://doi.org/10.1042/bst0211010</a>
  chicago: Jackson, Julie, N P J Cotton, Ross Williams, Tania Bizouarn, Mike Hutton,
    Leonid A Sazanov, and Christopher Thomas. “Proton-Translocating Transhydrogenase
    in Bacteria.” <i>Biochemical Society Transactions</i>. Portland Press, 1993. <a
    href="https://doi.org/10.1042/bst0211010">https://doi.org/10.1042/bst0211010</a>.
  ieee: J. Jackson <i>et al.</i>, “Proton-translocating transhydrogenase in bacteria,”
    <i>Biochemical Society Transactions</i>, vol. 21, no. 4. Portland Press, pp. 1010–1013,
    1993.
  ista: Jackson J, Cotton NPJ, Williams R, Bizouarn T, Hutton M, Sazanov LA, Thomas
    C. 1993. Proton-translocating transhydrogenase in bacteria. Biochemical Society
    Transactions. 21(4), 1010–1013.
  mla: Jackson, Julie, et al. “Proton-Translocating Transhydrogenase in Bacteria.”
    <i>Biochemical Society Transactions</i>, vol. 21, no. 4, Portland Press, 1993,
    pp. 1010–13, doi:<a href="https://doi.org/10.1042/bst0211010">10.1042/bst0211010</a>.
  short: J. Jackson, N.P.J. Cotton, R. Williams, T. Bizouarn, M. Hutton, L.A. Sazanov,
    C. Thomas, Biochemical Society Transactions 21 (1993) 1010–1013.
date_created: 2018-12-11T11:54:52Z
date_published: 1993-11-01T00:00:00Z
date_updated: 2022-06-01T12:16:19Z
day: '01'
doi: 10.1042/bst0211010
extern: '1'
external_id:
  pmid:
  - '8131888'
intvolume: '        21'
issue: '4'
language:
- iso: eng
main_file_link:
- url: https://portlandpress.com/biochemsoctrans/article-abstract/21/4/1010/86733/Proton-translocating-transhydrogenase-in-bacteria?redirectedFrom=fulltext
month: '11'
oa_version: None
page: 1010 - 1013
pmid: 1
publication: Biochemical Society Transactions
publication_identifier:
  issn:
  - 0300-5127
publication_status: published
publisher: Portland Press
publist_id: '5135'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Proton-translocating transhydrogenase in bacteria
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 21
year: '1993'
...
---
_id: '4589'
abstract:
- lang: eng
  text: "The theory of the natural numbers with linear order and monadic predicates
    underlies propositional linear temporal logic. To study temporal logics that are
    suitable for reasoning about real-time systems, we combine this classical theory
    of infinite state sequences with a theory of discrete time, via a monotonic function
    that maps every state to its time. The resulting theory of timed state sequences
    is shown to be decidable, albeit nonelementary, and its expressive power is characterized
    by ω-regular sets. Several more expressive variants are proved to be highly undecidable.
    This framework allows us to classify a wide variety of real-time logics according
    to their complexity and expressiveness. Indeed, it follows that most formalisms
    proposed in the literature cannot be decided. We are, however, able to identify
    two elementary real-time temporal logics as expressively complete fragments of
    the theory of timed state sequences, and we present tableau-based decision procedures
    for checking validity. Consequently, these two formalisms are well-suited for
    the specification and verification of real-time systems.\r\n\r\nCopyright © 1993
    Academic Press. All rights reserved."
acknowledgement: We thank David Dill, Zohar Manna, and Amir Pnueli for helpful discussion.
article_processing_charge: No
article_type: original
author:
- first_name: Rajeev
  full_name: Alur, Rajeev
  last_name: Alur
- first_name: Thomas A
  full_name: Henzinger, Thomas A
  id: 40876CD8-F248-11E8-B48F-1D18A9856A87
  last_name: Henzinger
  orcid: 0000−0002−2985−7724
citation:
  ama: 'Alur R, Henzinger TA. Real-time logics: Complexity and expressiveness. <i>Information
    and Computation</i>. 1993;104(1):35-77. doi:<a href="https://doi.org/10.1006/inco.1993.1025">10.1006/inco.1993.1025</a>'
  apa: 'Alur, R., &#38; Henzinger, T. A. (1993). Real-time logics: Complexity and
    expressiveness. <i>Information and Computation</i>. Elsevier. <a href="https://doi.org/10.1006/inco.1993.1025">https://doi.org/10.1006/inco.1993.1025</a>'
  chicago: 'Alur, Rajeev, and Thomas A Henzinger. “Real-Time Logics: Complexity and
    Expressiveness.” <i>Information and Computation</i>. Elsevier, 1993. <a href="https://doi.org/10.1006/inco.1993.1025">https://doi.org/10.1006/inco.1993.1025</a>.'
  ieee: 'R. Alur and T. A. Henzinger, “Real-time logics: Complexity and expressiveness,”
    <i>Information and Computation</i>, vol. 104, no. 1. Elsevier, pp. 35–77, 1993.'
  ista: 'Alur R, Henzinger TA. 1993. Real-time logics: Complexity and expressiveness.
    Information and Computation. 104(1), 35–77.'
  mla: 'Alur, Rajeev, and Thomas A. Henzinger. “Real-Time Logics: Complexity and Expressiveness.”
    <i>Information and Computation</i>, vol. 104, no. 1, Elsevier, 1993, pp. 35–77,
    doi:<a href="https://doi.org/10.1006/inco.1993.1025">10.1006/inco.1993.1025</a>.'
  short: R. Alur, T.A. Henzinger, Information and Computation 104 (1993) 35–77.
date_created: 2018-12-11T12:09:38Z
date_published: 1993-05-01T00:00:00Z
date_updated: 2022-03-23T13:08:27Z
day: '01'
doi: 10.1006/inco.1993.1025
extern: '1'
intvolume: '       104'
issue: '1'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://www.sciencedirect.com/science/article/pii/S0890540183710254?via%3Dihub
month: '05'
oa: 1
oa_version: Published Version
page: 35 - 77
publication: Information and Computation
publication_identifier:
  eissn:
  - 0890-5401
publication_status: published
publisher: Elsevier
publist_id: '116'
quality_controlled: '1'
scopus_import: '1'
status: public
title: 'Real-time logics: Complexity and expressiveness'
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 104
year: '1993'
...
---
_id: '4616'
abstract:
- lang: eng
  text: We present a model checking procedure and its implementation for the automatic
    verification of embedded systems. Systems are represented by hybrid automata -
    machines with finite control and real-valued variables modeling continuous environment
    parameters such as time, pressure, and temperature. System properties are specified
    in a real-time temporal logic and verified by symbolic computation. The verification
    procedure, implemented in Mathematica, is used to prove digital controllers and
    distributed algorithms correct. The verifier checks safety, liveness, time-bounded,
    and duration properties of hybrid automata
article_processing_charge: No
author:
- first_name: Rajeev
  full_name: Alur, Rajeev
  last_name: Alur
- first_name: Thomas A
  full_name: Henzinger, Thomas A
  id: 40876CD8-F248-11E8-B48F-1D18A9856A87
  last_name: Henzinger
  orcid: 0000−0002−2985−7724
- first_name: Pei
  full_name: Ho, Pei
  last_name: Ho
citation:
  ama: 'Alur R, Henzinger TA, Ho P. Automatic symbolic verification of embedded systems.
    In: <i>1993 Proceedings Real-Time Systems Symposium</i>. IEEE; 1993:2-11. doi:<a
    href="https://doi.org/10.1109/REAL.1993.393520 ">10.1109/REAL.1993.393520 </a>'
  apa: 'Alur, R., Henzinger, T. A., &#38; Ho, P. (1993). Automatic symbolic verification
    of embedded systems. In <i>1993 Proceedings Real-Time Systems Symposium</i> (pp.
    2–11). Raleigh, NC, United States of America: IEEE. <a href="https://doi.org/10.1109/REAL.1993.393520
    ">https://doi.org/10.1109/REAL.1993.393520 </a>'
  chicago: Alur, Rajeev, Thomas A Henzinger, and Pei Ho. “Automatic Symbolic Verification
    of Embedded Systems.” In <i>1993 Proceedings Real-Time Systems Symposium</i>,
    2–11. IEEE, 1993. <a href="https://doi.org/10.1109/REAL.1993.393520 ">https://doi.org/10.1109/REAL.1993.393520
    </a>.
  ieee: R. Alur, T. A. Henzinger, and P. Ho, “Automatic symbolic verification of embedded
    systems,” in <i>1993 Proceedings Real-Time Systems Symposium</i>, Raleigh, NC,
    United States of America, 1993, pp. 2–11.
  ista: 'Alur R, Henzinger TA, Ho P. 1993. Automatic symbolic verification of embedded
    systems. 1993 Proceedings Real-Time Systems Symposium. RTSS: Real-Time Systems
    Symposium, 2–11.'
  mla: Alur, Rajeev, et al. “Automatic Symbolic Verification of Embedded Systems.”
    <i>1993 Proceedings Real-Time Systems Symposium</i>, IEEE, 1993, pp. 2–11, doi:<a
    href="https://doi.org/10.1109/REAL.1993.393520 ">10.1109/REAL.1993.393520 </a>.
  short: R. Alur, T.A. Henzinger, P. Ho, in:, 1993 Proceedings Real-Time Systems Symposium,
    IEEE, 1993, pp. 2–11.
conference:
  end_date: 1993-12-03
  location: Raleigh, NC, United States of America
  name: 'RTSS: Real-Time Systems Symposium'
  start_date: 1993-12-01
date_created: 2018-12-11T12:09:46Z
date_published: 1993-01-01T00:00:00Z
date_updated: 2022-03-23T13:01:41Z
day: '01'
doi: '10.1109/REAL.1993.393520 '
extern: '1'
language:
- iso: eng
main_file_link:
- url: https://ieeexplore.ieee.org/document/393520
month: '01'
oa_version: None
page: 2 - 11
publication: 1993 Proceedings Real-Time Systems Symposium
publication_identifier:
  isbn:
  - 0-8186-4480-X
publication_status: published
publisher: IEEE
publist_id: '90'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Automatic symbolic verification of embedded systems
type: conference
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
year: '1993'
...
---
_id: '4618'
abstract:
- lang: eng
  text: We introduce the framework of hybrid automata as a model and specification
    language for hybrid systems. Hybrid automata can be viewed as a generalization
    of timed automata, in which the behavior of variables is governed in each state
    by a set of differential equations. We show that many of the examples considered
    in the workshop can be defined by hybrid automata. While the reachability problem
    is undecidable even for very restricted classes of hybrid automata, we present
    two semidecision procedures for verifying safety properties of piecewiselinear
    hybrid automata, in which all variables change at constant rates. The two procedures
    are based, respectively, on minimizing and computing fixpoints on generally infinite
    state spaces. We show that if the procedures terminate, then they give correct
    answers. We then demonstrate that for many of the typical workshop examples, the
    procedures do terminate and thus provide an automatic way for verifying their
    properties.
acknowledgement: BRA ESPRIT project REACT, National Science Foundation under grant
  CCR-9200794 , United States Air Force Office of Scientific Research contract F49620-93-1-0056.
alternative_title:
- LNCS
article_processing_charge: No
author:
- first_name: Rajeev
  full_name: Alur, Rajeev
  last_name: Alur
- first_name: Costas
  full_name: Courcoubetis, Costas
  last_name: Courcoubetis
- first_name: Thomas A
  full_name: Henzinger, Thomas A
  id: 40876CD8-F248-11E8-B48F-1D18A9856A87
  last_name: Henzinger
  orcid: 0000−0002−2985−7724
- first_name: Pei
  full_name: Ho, Pei
  last_name: Ho
citation:
  ama: 'Alur R, Courcoubetis C, Henzinger TA, Ho P. Hybrid automata: An algorithmic
    approach to the specification and verification of hybrid systems. In: Grossman
    R, Nerode A, Ravn A, Rischel H, eds. <i>Hybrid Systems</i>. Vol 736. Springer;
    1993:209-229. doi:<a href="https://doi.org/10.1007/3-540-57318-6_30">10.1007/3-540-57318-6_30</a>'
  apa: 'Alur, R., Courcoubetis, C., Henzinger, T. A., &#38; Ho, P. (1993). Hybrid
    automata: An algorithmic approach to the specification and verification of hybrid
    systems. In R. Grossman, A. Nerode, A. Ravn, &#38; H. Rischel (Eds.), <i>Hybrid
    Systems</i> (Vol. 736, pp. 209–229). Springer. <a href="https://doi.org/10.1007/3-540-57318-6_30">https://doi.org/10.1007/3-540-57318-6_30</a>'
  chicago: 'Alur, Rajeev, Costas Courcoubetis, Thomas A Henzinger, and Pei Ho. “Hybrid
    Automata: An Algorithmic Approach to the Specification and Verification of Hybrid
    Systems.” In <i>Hybrid Systems</i>, edited by Robert Grossman, Anil Nerode, Anders
    Ravn, and Hans Rischel, 736:209–29. Springer, 1993. <a href="https://doi.org/10.1007/3-540-57318-6_30">https://doi.org/10.1007/3-540-57318-6_30</a>.'
  ieee: 'R. Alur, C. Courcoubetis, T. A. Henzinger, and P. Ho, “Hybrid automata: An
    algorithmic approach to the specification and verification of hybrid systems,”
    in <i>Hybrid Systems</i>, 1993, vol. 736, pp. 209–229.'
  ista: 'Alur R, Courcoubetis C, Henzinger TA, Ho P. 1993. Hybrid automata: An algorithmic
    approach to the specification and verification of hybrid systems. Hybrid Systems.
    , LNCS, vol. 736, 209–229.'
  mla: 'Alur, Rajeev, et al. “Hybrid Automata: An Algorithmic Approach to the Specification
    and Verification of Hybrid Systems.” <i>Hybrid Systems</i>, edited by Robert Grossman
    et al., vol. 736, Springer, 1993, pp. 209–29, doi:<a href="https://doi.org/10.1007/3-540-57318-6_30">10.1007/3-540-57318-6_30</a>.'
  short: R. Alur, C. Courcoubetis, T.A. Henzinger, P. Ho, in:, R. Grossman, A. Nerode,
    A. Ravn, H. Rischel (Eds.), Hybrid Systems, Springer, 1993, pp. 209–229.
date_created: 2018-12-11T12:09:47Z
date_published: 1993-01-01T00:00:00Z
date_updated: 2022-03-21T11:04:54Z
day: '01'
doi: 10.1007/3-540-57318-6_30
editor:
- first_name: Robert
  full_name: Grossman, Robert
  last_name: Grossman
- first_name: Anil
  full_name: Nerode, Anil
  last_name: Nerode
- first_name: Anders
  full_name: Ravn, Anders
  last_name: Ravn
- first_name: Hans
  full_name: Rischel, Hans
  last_name: Rischel
extern: '1'
intvolume: '       736'
language:
- iso: eng
main_file_link:
- url: https://link.springer.com/chapter/10.1007/3-540-57318-6_30
month: '01'
oa_version: None
page: 209 - 229
publication: Hybrid Systems
publication_status: published
publisher: Springer
publist_id: '87'
quality_controlled: '1'
status: public
title: 'Hybrid automata: An algorithmic approach to the specification and verification
  of hybrid systems'
type: conference
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 736
year: '1993'
...
---
_id: '4619'
abstract:
- lang: eng
  text: Traditional approaches to the algorithmic verification of real-time systems
    are limited to checking program correctness with respect to concrete timing properties
    (e.g., &quot;message delivery within 10 milliseconds&quot;). We address the more
    realistic and more ambitious problem of deriving symbolic constraints on the timing
    properties required of real-time systems (e.g., &quot;message delivery within
    the time it takes to execute two assignment statements&quot;). To model this problem,
    we introduce parametric timed automata -- finite-state machines whose transitions
    are constrained with parametric timing requirements. The emptiness question for
    parametric timed automata is central to the verification problem. On the negative
    side, we show that in general this question is undecidable. On the positive side,
    we provide algorithms for checking the emptiness of restricted classes of parametric
    timed automata. The practical relevance of these classes is illustrated with several
    verification examples. There remains a gap between the automata classes for which
    we know that emptiness is decidable and undecidable, respectively, and this gap
    is related to various hard and open problems of logic and automata theory.
article_processing_charge: No
author:
- first_name: Rajeev
  full_name: Alur, Rajeev
  last_name: Alur
- first_name: Thomas A
  full_name: Henzinger, Thomas A
  id: 40876CD8-F248-11E8-B48F-1D18A9856A87
  last_name: Henzinger
  orcid: 0000−0002−2985−7724
- first_name: Moshe
  full_name: Vardi, Moshe
  last_name: Vardi
citation:
  ama: 'Alur R, Henzinger TA, Vardi M. Parametric real-time reasoning. In: <i>Proceedings
    of the 25th Annual ACM Symposium on Theory of Computing</i>. ACM; 1993:592-601.
    doi:<a href="https://doi.org/10.1145/167088.167242">10.1145/167088.167242</a>'
  apa: 'Alur, R., Henzinger, T. A., &#38; Vardi, M. (1993). Parametric real-time reasoning.
    In <i>Proceedings of the 25th annual ACM symposium on Theory of Computing</i>
    (pp. 592–601). San Diego, CA, United States of America: ACM. <a href="https://doi.org/10.1145/167088.167242">https://doi.org/10.1145/167088.167242</a>'
  chicago: Alur, Rajeev, Thomas A Henzinger, and Moshe Vardi. “Parametric Real-Time
    Reasoning.” In <i>Proceedings of the 25th Annual ACM Symposium on Theory of Computing</i>,
    592–601. ACM, 1993. <a href="https://doi.org/10.1145/167088.167242">https://doi.org/10.1145/167088.167242</a>.
  ieee: R. Alur, T. A. Henzinger, and M. Vardi, “Parametric real-time reasoning,”
    in <i>Proceedings of the 25th annual ACM symposium on Theory of Computing</i>,
    San Diego, CA, United States of America, 1993, pp. 592–601.
  ista: 'Alur R, Henzinger TA, Vardi M. 1993. Parametric real-time reasoning. Proceedings
    of the 25th annual ACM symposium on Theory of Computing. STOC: Symposium on the
    Theory of Computing, 592–601.'
  mla: Alur, Rajeev, et al. “Parametric Real-Time Reasoning.” <i>Proceedings of the
    25th Annual ACM Symposium on Theory of Computing</i>, ACM, 1993, pp. 592–601,
    doi:<a href="https://doi.org/10.1145/167088.167242">10.1145/167088.167242</a>.
  short: R. Alur, T.A. Henzinger, M. Vardi, in:, Proceedings of the 25th Annual ACM
    Symposium on Theory of Computing, ACM, 1993, pp. 592–601.
conference:
  end_date: 1993-05-18
  location: San Diego, CA, United States of America
  name: 'STOC: Symposium on the Theory of Computing'
  start_date: 1993-05-16
date_created: 2018-12-11T12:09:47Z
date_published: 1993-06-01T00:00:00Z
date_updated: 2022-03-21T11:11:37Z
day: '01'
doi: 10.1145/167088.167242
extern: '1'
language:
- iso: eng
main_file_link:
- url: https://dl.acm.org/doi/10.1145/167088.167242
month: '06'
oa_version: None
page: 592 - 601
publication: Proceedings of the 25th annual ACM symposium on Theory of Computing
publication_status: published
publisher: ACM
publist_id: '88'
quality_controlled: '1'
status: public
title: Parametric real-time reasoning
type: conference
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
year: '1993'
...
---
_id: '4620'
abstract:
- lang: eng
  text: We present a verification algorithm for duration properties of finite-state
    real-time systems. While simple real-time properties constrain the total elapsed
    time between events, duration properties constrain the accumulated time during
    which certain state predicates hold. We formalize the concept of durations by
    introducing duration measures for (dense-time) timed automata. Given a timed automaton
    with a duration measure, a start and a target state, and a duration constraint,
    the duration-bounded reachability problem asks if there is a run of the automaton
    from the start state to the target state such that the accumulated duration along
    the run satisfies the constraint. Our main result is a novel decision procedure
    for solving the duration-bounded reachability problem. We also prove that the
    problem is PSPACE-complete and demonstrate how the solution can be used to verify
    interesting duration properties of real-time systems.
acknowledgement: BRA ESPRIT project REACT, National Science Foundation grant CCR-9200794
  United States Air Force Office of Scientific Research contract F49620-93-1-0056
alternative_title:
- LNCS
article_processing_charge: No
author:
- first_name: Rajeev
  full_name: Alur, Rajeev
  last_name: Alur
- first_name: Costas
  full_name: Courcoubetis, Costas
  last_name: Courcoubetis
- first_name: Thomas A
  full_name: Henzinger, Thomas A
  id: 40876CD8-F248-11E8-B48F-1D18A9856A87
  last_name: Henzinger
  orcid: 0000−0002−2985−7724
citation:
  ama: 'Alur R, Courcoubetis C, Henzinger TA. Computing accumulated delays in real-time
    systems. In: <i>5th International Conference on Computer Aided Verification</i>.
    Vol 697. Springer; 1993:181-193. doi:<a href="https://doi.org/10.1007/3-540-56922-7_16">10.1007/3-540-56922-7_16</a>'
  apa: 'Alur, R., Courcoubetis, C., &#38; Henzinger, T. A. (1993). Computing accumulated
    delays in real-time systems. In <i>5th International Conference on Computer Aided
    Verification</i> (Vol. 697, pp. 181–193). Elounda, Greece: Springer. <a href="https://doi.org/10.1007/3-540-56922-7_16">https://doi.org/10.1007/3-540-56922-7_16</a>'
  chicago: Alur, Rajeev, Costas Courcoubetis, and Thomas A Henzinger. “Computing Accumulated
    Delays in Real-Time Systems.” In <i>5th International Conference on Computer Aided
    Verification</i>, 697:181–93. Springer, 1993. <a href="https://doi.org/10.1007/3-540-56922-7_16">https://doi.org/10.1007/3-540-56922-7_16</a>.
  ieee: R. Alur, C. Courcoubetis, and T. A. Henzinger, “Computing accumulated delays
    in real-time systems,” in <i>5th International Conference on Computer Aided Verification</i>,
    Elounda, Greece, 1993, vol. 697, pp. 181–193.
  ista: 'Alur R, Courcoubetis C, Henzinger TA. 1993. Computing accumulated delays
    in real-time systems. 5th International Conference on Computer Aided Verification.
    CAV: Computer Aided Verification, LNCS, vol. 697, 181–193.'
  mla: Alur, Rajeev, et al. “Computing Accumulated Delays in Real-Time Systems.” <i>5th
    International Conference on Computer Aided Verification</i>, vol. 697, Springer,
    1993, pp. 181–93, doi:<a href="https://doi.org/10.1007/3-540-56922-7_16">10.1007/3-540-56922-7_16</a>.
  short: R. Alur, C. Courcoubetis, T.A. Henzinger, in:, 5th International Conference
    on Computer Aided Verification, Springer, 1993, pp. 181–193.
conference:
  end_date: 1993-07-01
  location: Elounda, Greece
  name: 'CAV: Computer Aided Verification'
  start_date: 1993-06-28
date_created: 2018-12-11T12:09:47Z
date_published: 1993-01-01T00:00:00Z
date_updated: 2022-03-21T13:55:53Z
day: '01'
doi: 10.1007/3-540-56922-7_16
extern: '1'
intvolume: '       697'
language:
- iso: eng
main_file_link:
- url: https://link.springer.com/chapter/10.1007/3-540-56922-7_16
month: '01'
oa_version: None
page: 181 - 193
publication: 5th International Conference on Computer Aided Verification
publication_status: published
publisher: Springer
publist_id: '89'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Computing accumulated delays in real-time systems
type: conference
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 697
year: '1993'
...
---
_id: '3446'
abstract:
- lang: eng
  text: An effective character recognition procedure implemented on a new type of
    hardware system and using a new architecture called CNND is proposed. This CNND
    contains one or more analog cellular neural networks (CNNs) and some digital logic,
    combining the advantages of the fast analog CNN signal processing and the fast
    and easy decision capability of digital logic. It is shown that the CNND system
    can be used for recognition of multifont printed or handwritten characters and
    could recognize 100,000 char/s with a recognition rate of more than 95%. The more
    advantage of the system over competing types is that there is not an extra feature
    extraction procedure implemented in slow hardware
article_processing_charge: No
article_type: original
author:
- first_name: Tamas
  full_name: Sziranyi, Tamas
  last_name: Sziranyi
- first_name: Jozsef L
  full_name: Csicsvari, Jozsef L
  id: 3FA14672-F248-11E8-B48F-1D18A9856A87
  last_name: Csicsvari
  orcid: 0000-0002-5193-4036
citation:
  ama: 'Sziranyi T, Csicsvari JL. High-speed character recognition using a dual cellular
    neural network architecture (CNND). <i>IEEE Transactions on Circuits and Systems
    II: Analog and Digital Signal Processing</i>. 1993;40(3):223-231. doi:<a href="https://doi.org/10.1109/82.222823">10.1109/82.222823</a>'
  apa: 'Sziranyi, T., &#38; Csicsvari, J. L. (1993). High-speed character recognition
    using a dual cellular neural network architecture (CNND). <i>IEEE Transactions
    on Circuits and Systems II: Analog and Digital Signal Processing</i>. IEEE. <a
    href="https://doi.org/10.1109/82.222823">https://doi.org/10.1109/82.222823</a>'
  chicago: 'Sziranyi, Tamas, and Jozsef L Csicsvari. “High-Speed Character Recognition
    Using a Dual Cellular Neural Network Architecture (CNND).” <i>IEEE Transactions
    on Circuits and Systems II: Analog and Digital Signal Processing</i>. IEEE, 1993.
    <a href="https://doi.org/10.1109/82.222823">https://doi.org/10.1109/82.222823</a>.'
  ieee: 'T. Sziranyi and J. L. Csicsvari, “High-speed character recognition using
    a dual cellular neural network architecture (CNND),” <i>IEEE Transactions on Circuits
    and Systems II: Analog and Digital Signal Processing</i>, vol. 40, no. 3. IEEE,
    pp. 223–231, 1993.'
  ista: 'Sziranyi T, Csicsvari JL. 1993. High-speed character recognition using a
    dual cellular neural network architecture (CNND). IEEE Transactions on Circuits
    and Systems II: Analog and Digital Signal Processing. 40(3), 223–231.'
  mla: 'Sziranyi, Tamas, and Jozsef L. Csicsvari. “High-Speed Character Recognition
    Using a Dual Cellular Neural Network Architecture (CNND).” <i>IEEE Transactions
    on Circuits and Systems II: Analog and Digital Signal Processing</i>, vol. 40,
    no. 3, IEEE, 1993, pp. 223–31, doi:<a href="https://doi.org/10.1109/82.222823">10.1109/82.222823</a>.'
  short: 'T. Sziranyi, J.L. Csicsvari, IEEE Transactions on Circuits and Systems II:
    Analog and Digital Signal Processing 40 (1993) 223–231.'
date_created: 2018-12-11T12:03:22Z
date_published: 1993-03-01T00:00:00Z
date_updated: 2022-03-30T14:44:44Z
day: '01'
doi: 10.1109/82.222823
extern: '1'
intvolume: '        40'
issue: '3'
language:
- iso: eng
main_file_link:
- url: https://ieeexplore.ieee.org/document/222823
month: '03'
oa_version: None
page: 223 - 231
publication: 'IEEE Transactions on Circuits and Systems II: Analog and Digital Signal
  Processing'
publication_identifier:
  issn:
  - 1057-7130
publication_status: published
publisher: IEEE
publist_id: '2941'
quality_controlled: '1'
scopus_import: '1'
status: public
title: High-speed character recognition using a dual cellular neural network architecture
  (CNND)
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 40
year: '1993'
...
---
_id: '3451'
acknowledgement: I thank Prof. B. Sakmann for generous support and Drs. M. Häusser
  and A. Villarroel for critically reading the manuscript.
alternative_title:
- 'Annals of the New York Academy of Sciences '
article_processing_charge: No
author:
- first_name: Peter M
  full_name: Jonas, Peter M
  id: 353C1B58-F248-11E8-B48F-1D18A9856A87
  last_name: Jonas
  orcid: 0000-0001-5001-4804
citation:
  ama: 'Jonas PM. Glutamate receptors in the central nervous system. In: <i>Molecular
    Basis of Ion Channels and Receptors Involved in Nerve Excitation, Synaptic Transmission,
    and Muscle Contraction</i>. Vol 707. Annals of the New York Academy of Sciences.
    New York Academy of Sciences; 1993:126-135. doi:<a href="https://doi.org/10.1111/j.1749-6632.1993.tb38048.x">10.1111/j.1749-6632.1993.tb38048.x</a>'
  apa: Jonas, P. M. (1993). Glutamate receptors in the central nervous system. In
    <i>Molecular Basis of Ion Channels and Receptors Involved in Nerve Excitation,
    Synaptic Transmission, and Muscle Contraction</i> (Vol. 707, pp. 126–135). New
    York Academy of Sciences. <a href="https://doi.org/10.1111/j.1749-6632.1993.tb38048.x">https://doi.org/10.1111/j.1749-6632.1993.tb38048.x</a>
  chicago: Jonas, Peter M. “Glutamate Receptors in the Central Nervous System.” In
    <i>Molecular Basis of Ion Channels and Receptors Involved in Nerve Excitation,
    Synaptic Transmission, and Muscle Contraction</i>, 707:126–35. Annals of the New
    York Academy of Sciences. New York Academy of Sciences, 1993. <a href="https://doi.org/10.1111/j.1749-6632.1993.tb38048.x">https://doi.org/10.1111/j.1749-6632.1993.tb38048.x</a>.
  ieee: P. M. Jonas, “Glutamate receptors in the central nervous system,” in <i>Molecular
    Basis of Ion Channels and Receptors Involved in Nerve Excitation, Synaptic Transmission,
    and Muscle Contraction</i>, vol. 707, New York Academy of Sciences, 1993, pp.
    126–135.
  ista: 'Jonas PM. 1993.Glutamate receptors in the central nervous system. In: Molecular
    Basis of Ion Channels and Receptors Involved in Nerve Excitation, Synaptic Transmission,
    and Muscle Contraction. Annals of the New York Academy of Sciences , vol. 707,
    126–135.'
  mla: Jonas, Peter M. “Glutamate Receptors in the Central Nervous System.” <i>Molecular
    Basis of Ion Channels and Receptors Involved in Nerve Excitation, Synaptic Transmission,
    and Muscle Contraction</i>, vol. 707, New York Academy of Sciences, 1993, pp.
    126–35, doi:<a href="https://doi.org/10.1111/j.1749-6632.1993.tb38048.x">10.1111/j.1749-6632.1993.tb38048.x</a>.
  short: P.M. Jonas, in:, Molecular Basis of Ion Channels and Receptors Involved in
    Nerve Excitation, Synaptic Transmission, and Muscle Contraction, New York Academy
    of Sciences, 1993, pp. 126–135.
date_created: 2018-12-11T12:03:24Z
date_published: 1993-12-20T00:00:00Z
date_updated: 2022-03-30T12:35:23Z
day: '20'
doi: 10.1111/j.1749-6632.1993.tb38048.x
extern: '1'
external_id:
  pmid:
  - '9729204'
intvolume: '       707'
language:
- iso: eng
main_file_link:
- url: https://nyaspubs.onlinelibrary.wiley.com/doi/10.1111/j.1749-6632.1993.tb38048.x
month: '12'
oa_version: None
page: 126 - 135
pmid: 1
publication: Molecular Basis of Ion Channels and Receptors Involved in Nerve Excitation,
  Synaptic Transmission, and Muscle Contraction
publication_status: published
publisher: New York Academy of Sciences
publist_id: '2936'
quality_controlled: '1'
scopus_import: '1'
series_title: Annals of the New York Academy of Sciences
status: public
title: Glutamate receptors in the central nervous system
type: book_chapter
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 707
year: '1993'
...
---
_id: '3452'
abstract:
- lang: eng
  text: In recent years, considerable progress in our understanding of the molecular
    events underlying excitatory synaptic transmission has been made. This progress
    was mainly achieved by technical advances, among them the patch-clamp technique
    in brain slices (Edwards et al., 1989), fast application of agonists (Franke et
    al., 1987), and cloning and functional expression of GluR channels of the nonNMDA
    type (e.g., Hollmann et al., 1989). A suitable model for studying excitatory postsynaptic
    currents (EPSCs) in the brain slice with patch-clamp techniques is the mossy fiber
    synapse on CA3 pyramidal cells of rat hippocampus (MF-CA3 synapse). This synapse
    is located close to the cell soma and should provide almost ideal space-clamp
    conditions. A comparison of MF-CA3 EPSCs with the currents activated by fast application
    of glutamate on membrane patches isolated from CA3 cell somata suggests that the
    concentration of glutamate in the synaptic cleft during excitatory synaptic transmission
    is high (about 1 mM) and that the transmitter remains in the synaptic cleft only
    briefly (about 1 ms). It seems likely that desensitization influences the peak
    amplitude of the EPSC in several ways. Brief pulses of glutamate cause desensitization,
    from which the glutamate receptor channels recover only slowly, and micromolar
    ambient glutamate concentrations produce desensitization at equilibrium. From
    the functional properties of recombinant GluR channels, in situ hybridization
    data, and patch-clamp experiments on different neuronal and nonneuronal cell types,
    a picture of the molecular identity of native channels emerges. In neurons of
    the hippocampus the pharmacological features of these channels were similar to
    recombinant channels assembled from subunits of the AMPA/kainate subtype which
    are strongly expressed in these cells. The native channels are characterized by
    outward rectification of the steady-state I-V and low Ca permeability, similar
    to recombinant channels containing the GluR-B subunit. This is consistent with
    the ubiquitous expression of this subunit in hippocampal neurones. In contrast,
    GluR channels from cerebellar glial cells, which uniquely in the central nervous
    system lack the expression of GluR-B subunits, show double rectification and high
    Ca permeability. The results suggest that the native functional nonNMDA glutamate
    receptor channels in the CNS are assembled form subunits of the AMPA/kainate subtype
    in a cell-specific way, with the functional properties of GluR channels in neurones
    being dominated by the GluR-B subunit.
alternative_title:
- EXS
article_processing_charge: No
author:
- first_name: Peter M
  full_name: Jonas, Peter M
  id: 353C1B58-F248-11E8-B48F-1D18A9856A87
  last_name: Jonas
  orcid: 0000-0001-5001-4804
citation:
  ama: 'Jonas PM. AMPA-type glutamate receptors - nonselective cation channels mediating
    fast excitatory transmission in the CNS. In: Siemen D, ed. <i>Nonselective Cation
    Channels: Pharmacology, Physiology and Biophysics.</i> Vol 66. Birkhäuser; 1993:61-76.
    doi:<a href="https://doi.org/10.1007/978-3-0348-7327-7_4">10.1007/978-3-0348-7327-7_4</a>'
  apa: 'Jonas, P. M. (1993). AMPA-type glutamate receptors - nonselective cation channels
    mediating fast excitatory transmission in the CNS. In D. Siemen (Ed.), <i>Nonselective
    cation channels: Pharmacology, Physiology and Biophysics.</i> (Vol. 66, pp. 61–76).
    Birkhäuser. <a href="https://doi.org/10.1007/978-3-0348-7327-7_4">https://doi.org/10.1007/978-3-0348-7327-7_4</a>'
  chicago: 'Jonas, Peter M. “AMPA-Type Glutamate Receptors - Nonselective Cation Channels
    Mediating Fast Excitatory Transmission in the CNS.” In <i>Nonselective Cation
    Channels: Pharmacology, Physiology and Biophysics.</i>, edited by Detlef Siemen,
    66:61–76. Birkhäuser, 1993. <a href="https://doi.org/10.1007/978-3-0348-7327-7_4">https://doi.org/10.1007/978-3-0348-7327-7_4</a>.'
  ieee: 'P. M. Jonas, “AMPA-type glutamate receptors - nonselective cation channels
    mediating fast excitatory transmission in the CNS,” in <i>Nonselective cation
    channels: Pharmacology, Physiology and Biophysics.</i>, vol. 66, D. Siemen, Ed.
    Birkhäuser, 1993, pp. 61–76.'
  ista: 'Jonas PM. 1993.AMPA-type glutamate receptors - nonselective cation channels
    mediating fast excitatory transmission in the CNS. In: Nonselective cation channels:
    Pharmacology, Physiology and Biophysics. EXS, vol. 66, 61–76.'
  mla: 'Jonas, Peter M. “AMPA-Type Glutamate Receptors - Nonselective Cation Channels
    Mediating Fast Excitatory Transmission in the CNS.” <i>Nonselective Cation Channels:
    Pharmacology, Physiology and Biophysics.</i>, edited by Detlef Siemen, vol. 66,
    Birkhäuser, 1993, pp. 61–76, doi:<a href="https://doi.org/10.1007/978-3-0348-7327-7_4">10.1007/978-3-0348-7327-7_4</a>.'
  short: 'P.M. Jonas, in:, D. Siemen (Ed.), Nonselective Cation Channels: Pharmacology,
    Physiology and Biophysics., Birkhäuser, 1993, pp. 61–76.'
date_created: 2018-12-11T12:03:24Z
date_published: 1993-01-01T00:00:00Z
date_updated: 2022-03-30T11:46:44Z
day: '01'
doi: 10.1007/978-3-0348-7327-7_4
editor:
- first_name: Detlef
  full_name: Siemen, Detlef
  last_name: Siemen
extern: '1'
external_id:
  pmid:
  - '7505664'
intvolume: '        66'
language:
- iso: eng
main_file_link:
- url: https://link.springer.com/chapter/10.1007/978-3-0348-7327-7_4
month: '01'
oa_version: None
page: 61 - 76
pmid: 1
publication: 'Nonselective cation channels: Pharmacology, Physiology and Biophysics.'
publication_identifier:
  isbn:
  - 978-3-0348-7327-7
publication_status: published
publisher: Birkhäuser
publist_id: '2935'
quality_controlled: '1'
scopus_import: '1'
status: public
title: AMPA-type glutamate receptors - nonselective cation channels mediating fast
  excitatory transmission in the CNS
type: book_chapter
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 66
year: '1993'
...
---
_id: '3473'
abstract:
- lang: eng
  text: Sixteen different K+ channel subtypes have been cloned from mammalian tissue.
    Considering their sequence homology to Drosophila Shaker, Shab, Shaw and Shal
    channels, they were classified into four corresponding classes Kv1-4. All K+ channels
    belonging to these classes consist of four subunits with each six hydrophobic
    segments (S1-S6) and a characteristic structure-function relationship of certain
    domains in their amino acid sequence. These domains are, the inactivation gate
    in the N-terminal region of the sequence, the voltage sensor in the fourth hydrophobic
    segment (S4), and the pore-region in the H5 segment between S5 and S6. In some
    functional properties K+ channels cloned from the mammalian brain, however, differ
    from Drosophila K+ channels. These are pharmacological differences, differences
    in the threshold of activation and in regulation of inactivation. Part of these
    differences are important to understand their physiological role in the brain.
    Based on their functional characteristics the expression pattern of cloned K+
    channels in the rat brain can be correlated with the properties of K+ currents
    measured in central neurones.
article_processing_charge: No
article_type: original
author:
- first_name: Peter
  full_name: Ruppersberg, Peter
  last_name: Ruppersberg
- first_name: Mamfred
  full_name: Ermler, Mamfred
  last_name: Ermler
- first_name: Martin
  full_name: Knopf, Martin
  last_name: Knopf
- first_name: Wilfried
  full_name: Kues, Wilfried
  last_name: Kues
- first_name: Peter M
  full_name: Jonas, Peter M
  id: 353C1B58-F248-11E8-B48F-1D18A9856A87
  last_name: Jonas
  orcid: 0000-0001-5001-4804
- first_name: Michael
  full_name: Koenen, Michael
  last_name: Koenen
citation:
  ama: Ruppersberg P, Ermler M, Knopf M, Kues W, Jonas PM, Koenen M. Properties of
    Shaker-homologous potassium channels expressed in the mammalian brain. <i>Cellular
    Physiology and Biochemistry</i>. 1993;3:250-269. doi:<a href="https://doi.org/10.1159/000154691">10.1159/000154691</a>
  apa: Ruppersberg, P., Ermler, M., Knopf, M., Kues, W., Jonas, P. M., &#38; Koenen,
    M. (1993). Properties of Shaker-homologous potassium channels expressed in the
    mammalian brain. <i>Cellular Physiology and Biochemistry</i>. S. Karger AG. <a
    href="https://doi.org/10.1159/000154691">https://doi.org/10.1159/000154691</a>
  chicago: Ruppersberg, Peter, Mamfred Ermler, Martin Knopf, Wilfried Kues, Peter
    M Jonas, and Michael Koenen. “Properties of Shaker-Homologous Potassium Channels
    Expressed in the Mammalian Brain.” <i>Cellular Physiology and Biochemistry</i>.
    S. Karger AG, 1993. <a href="https://doi.org/10.1159/000154691">https://doi.org/10.1159/000154691</a>.
  ieee: P. Ruppersberg, M. Ermler, M. Knopf, W. Kues, P. M. Jonas, and M. Koenen,
    “Properties of Shaker-homologous potassium channels expressed in the mammalian
    brain.,” <i>Cellular Physiology and Biochemistry</i>, vol. 3. S. Karger AG, pp.
    250–269, 1993.
  ista: Ruppersberg P, Ermler M, Knopf M, Kues W, Jonas PM, Koenen M. 1993. Properties
    of Shaker-homologous potassium channels expressed in the mammalian brain. Cellular
    Physiology and Biochemistry. 3, 250–269.
  mla: Ruppersberg, Peter, et al. “Properties of Shaker-Homologous Potassium Channels
    Expressed in the Mammalian Brain.” <i>Cellular Physiology and Biochemistry</i>,
    vol. 3, S. Karger AG, 1993, pp. 250–69, doi:<a href="https://doi.org/10.1159/000154691">10.1159/000154691</a>.
  short: P. Ruppersberg, M. Ermler, M. Knopf, W. Kues, P.M. Jonas, M. Koenen, Cellular
    Physiology and Biochemistry 3 (1993) 250–269.
date_created: 2018-12-11T12:03:31Z
date_published: 1993-01-01T00:00:00Z
date_updated: 2022-03-30T10:21:04Z
day: '01'
doi: 10.1159/000154691
extern: '1'
intvolume: '         3'
language:
- iso: eng
main_file_link:
- url: https://www.karger.com/Article/Abstract/154691
month: '01'
oa_version: None
page: 250 - 269
publication: Cellular Physiology and Biochemistry
publication_identifier:
  issn:
  - 1015-8987
publication_status: published
publisher: S. Karger AG
publist_id: '2914'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Properties of Shaker-homologous potassium channels expressed in the mammalian
  brain.
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 3
year: '1993'
...
---
_id: '3474'
abstract:
- lang: eng
  text: 1. Excitatory postsynaptic currents (EPSCs) were recorded in CA3 pyramidal
    cells of hippocampal slices of 15- to 24-day-old rats (22 degrees C) using the
    whole-cell configuration of the patch clamp technique. 2. Composite EPSCs were
    evoked by extracellular stimulation of the mossy fibre tract. Using the selective
    blockers 6-cyano-7-nitroquinoxaline-2,3-dione (CNQX) and D-2-amino-5-phosphonopentanoic
    acid (APV), a major alpha-amino-3-hydroxy-5-methylisoxazole-4-propionate (AMPA)/kainate
    receptor-mediated component and a minor NMDA receptor-mediated component with
    slower time course were distinguished. For the AMPA/kainate receptor-mediated
    component, the peak current-voltage (I-V) relation was linear, with a reversal
    potential close to 0 mV. The half-maximal blocking concentration of CNQX was 353
    nM. 3. Unitary EPSCs of the mossy fibre terminal (MF)-CA3 pyramidal cell synapse
    were evoked at membrane potentials of -70 to -90 mV by low-intensity extracellular
    stimulation of granule cell somata using fine-tipped pipettes. The EPSC peak amplitude
    as a function of stimulus intensity showed all-or-none behaviour. The region of
    low threshold was restricted to a few micrometres. This suggests that extracellular
    stimulation was focal, and that the stimulus-evoked EPSCs were unitary. 4. Latency
    and rise time histograms of EPSCs evoked by granule cell stimulation showed narrow
    unimodal distributions within each experiment. The mean latency was 4.2 +/- 1.0
    ms, and the mean 20-80% rise time was 0.6 +/- 0.1 ms (23 cells). When fitted within
    the range 0.7 ms to 20 ms after the peak, the decay of the EPSCs with the fastest
    rise (rise time 0.5 ms or less) could be described by a single exponential function;
    the mean time constant was in the range 3.0-6.6 ms with a mean of 4.8 ms (8 cells).
    5. Peak amplitudes of the EPSCs evoked by suprathreshold granule cell stimulation
    fluctuated between trials. The apparent EPSC peak conductance in normal extracellular
    solution (2 mM Ca2+, 1 mM Mg2+), excluding failures, was 1 nS. Reducing the Ca2+
    concentration and increasing the Mg2+ concentration reduced the mean peak amplitude
    in a concentration-dependent manner. 6. Peaks in EPSC peak amplitude distributions
    were apparent in low Ca2+ and high Mg2+. Using the criteria of equidistance and
    the presence of peaks and dips in the autocorrelation function, five of nine EPSC
    peak amplitude distributions were judged to be quantal.
acknowledgement: "We are indebted to Professor B. Katz for critically reading the
  manuscript and for helpful suggestions. We especially thank Professor D. Colquhoun
  for several discussions, for generously providing the source codes of programs for
  maximum-likelihood fit with sums of Gaussian functions, a routine for calculating
  the error function and for critically reading the manuscript. We also thank Drs
  A. Larkman, P. Ruppersberg, N. Spuston and G. Stuart for critically reading the
  manuscript, P. Andersen, B. Betz, J. Evans, K. Harris, E. v. Kitzing, R. Rahamimov
  and K. Stratford for helpful discussions, and J. J. B. Jack for much-needed advice
  and guidance to G.M. We thank K. Bauer, F. Helmchen, M. Huke, B. Manz and especially
  A. Roth for computer programming, B. Werner for typing the manuscript, and M. Kaiser
  for excellent technical assistance. Part of the project was supported by the Deutsche
  Forschungsgemeinschaft (SFB-317)\r\nand the Wellcome Trust."
article_processing_charge: No
article_type: original
author:
- first_name: Peter M
  full_name: Jonas, Peter M
  id: 353C1B58-F248-11E8-B48F-1D18A9856A87
  last_name: Jonas
  orcid: 0000-0001-5001-4804
- first_name: Guy
  full_name: Major, Guy
  last_name: Major
- first_name: Bert
  full_name: Sakmann, Bert
  last_name: Sakmann
citation:
  ama: Jonas PM, Major G, Sakmann B. Quantal components of unitary EPSCs at the mossy
    fibre synapse on CA3 pyramidal cells of rat hippocampus. <i>Journal of Physiology</i>.
    1993;472:615-663. doi:<a href="https://doi.org/10.1113/jphysiol.1993.sp019965">10.1113/jphysiol.1993.sp019965</a>
  apa: Jonas, P. M., Major, G., &#38; Sakmann, B. (1993). Quantal components of unitary
    EPSCs at the mossy fibre synapse on CA3 pyramidal cells of rat hippocampus. <i>Journal
    of Physiology</i>. Wiley-Blackwell. <a href="https://doi.org/10.1113/jphysiol.1993.sp019965">https://doi.org/10.1113/jphysiol.1993.sp019965</a>
  chicago: Jonas, Peter M, Guy Major, and Bert Sakmann. “Quantal Components of Unitary
    EPSCs at the Mossy Fibre Synapse on CA3 Pyramidal Cells of Rat Hippocampus.” <i>Journal
    of Physiology</i>. Wiley-Blackwell, 1993. <a href="https://doi.org/10.1113/jphysiol.1993.sp019965">https://doi.org/10.1113/jphysiol.1993.sp019965</a>.
  ieee: P. M. Jonas, G. Major, and B. Sakmann, “Quantal components of unitary EPSCs
    at the mossy fibre synapse on CA3 pyramidal cells of rat hippocampus,” <i>Journal
    of Physiology</i>, vol. 472. Wiley-Blackwell, pp. 615–663, 1993.
  ista: Jonas PM, Major G, Sakmann B. 1993. Quantal components of unitary EPSCs at
    the mossy fibre synapse on CA3 pyramidal cells of rat hippocampus. Journal of
    Physiology. 472, 615–663.
  mla: Jonas, Peter M., et al. “Quantal Components of Unitary EPSCs at the Mossy Fibre
    Synapse on CA3 Pyramidal Cells of Rat Hippocampus.” <i>Journal of Physiology</i>,
    vol. 472, Wiley-Blackwell, 1993, pp. 615–63, doi:<a href="https://doi.org/10.1113/jphysiol.1993.sp019965">10.1113/jphysiol.1993.sp019965</a>.
  short: P.M. Jonas, G. Major, B. Sakmann, Journal of Physiology 472 (1993) 615–663.
date_created: 2018-12-11T12:03:31Z
date_published: 1993-12-01T00:00:00Z
date_updated: 2022-03-30T09:33:19Z
day: '01'
doi: 10.1113/jphysiol.1993.sp019965
extern: '1'
external_id:
  pmid:
  - '7908327'
intvolume: '       472'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1160505
month: '12'
oa: 1
oa_version: Published Version
page: 615 - 663
pmid: 1
publication: Journal of Physiology
publication_identifier:
  issn:
  - 0022-3751
publication_status: published
publisher: Wiley-Blackwell
publist_id: '2913'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Quantal components of unitary EPSCs at the mossy fibre synapse on CA3 pyramidal
  cells of rat hippocampus
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 472
year: '1993'
...
---
_id: '3568'
article_processing_charge: No
author:
- first_name: Herbert
  full_name: Edelsbrunner, Herbert
  id: 3FB178DA-F248-11E8-B48F-1D18A9856A87
  last_name: Edelsbrunner
  orcid: 0000-0002-9823-6833
citation:
  ama: 'Edelsbrunner H. Geometric algorithms. In: <i>Handbook of Convex Geometry</i>.
    North Holland; 1993:699-735. doi:<a href="https://doi.org/10.1016/C2009-0-15705-7">10.1016/C2009-0-15705-7</a>'
  apa: Edelsbrunner, H. (1993). Geometric algorithms. In <i>Handbook of Convex Geometry</i>
    (pp. 699–735). North Holland. <a href="https://doi.org/10.1016/C2009-0-15705-7">https://doi.org/10.1016/C2009-0-15705-7</a>
  chicago: Edelsbrunner, Herbert. “Geometric Algorithms.” In <i>Handbook of Convex
    Geometry</i>, 699–735. North Holland, 1993. <a href="https://doi.org/10.1016/C2009-0-15705-7">https://doi.org/10.1016/C2009-0-15705-7</a>.
  ieee: H. Edelsbrunner, “Geometric algorithms,” in <i>Handbook of Convex Geometry</i>,
    North Holland, 1993, pp. 699–735.
  ista: 'Edelsbrunner H. 1993.Geometric algorithms. In: Handbook of Convex Geometry.
    , 699–735.'
  mla: Edelsbrunner, Herbert. “Geometric Algorithms.” <i>Handbook of Convex Geometry</i>,
    North Holland, 1993, pp. 699–735, doi:<a href="https://doi.org/10.1016/C2009-0-15705-7">10.1016/C2009-0-15705-7</a>.
  short: H. Edelsbrunner, in:, Handbook of Convex Geometry, North Holland, 1993, pp.
    699–735.
date_created: 2018-12-11T12:04:00Z
date_published: 1993-08-24T00:00:00Z
date_updated: 2022-03-30T09:30:11Z
day: '24'
doi: 10.1016/C2009-0-15705-7
extern: '1'
language:
- iso: eng
main_file_link:
- url: https://www.sciencedirect.com/book/9780444895967/handbook-of-convex-geometry
month: '08'
oa_version: None
page: 699 - 735
publication: Handbook of Convex Geometry
publication_identifier:
  isbn:
  - 978-0-444-89596-7
publication_status: published
publisher: North Holland
publist_id: '2817'
status: public
title: Geometric algorithms
type: book_chapter
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
year: '1993'
...
---
_id: '3569'
article_processing_charge: No
author:
- first_name: Herbert
  full_name: Edelsbrunner, Herbert
  id: 3FB178DA-F248-11E8-B48F-1D18A9856A87
  last_name: Edelsbrunner
  orcid: 0000-0002-9823-6833
citation:
  ama: 'Edelsbrunner H. Computational geometry. In: <i>Current Trends in Theoretical
    Computer Science, Essays and Tutorials</i>. World Scientific Publishing; 1993:1-48.'
  apa: Edelsbrunner, H. (1993). Computational geometry. In <i>Current Trends in Theoretical
    Computer Science, Essays and Tutorials</i> (pp. 1–48). World Scientific Publishing.
  chicago: Edelsbrunner, Herbert. “Computational Geometry.” In <i>Current Trends in
    Theoretical Computer Science, Essays and Tutorials</i>, 1–48. World Scientific
    Publishing, 1993.
  ieee: H. Edelsbrunner, “Computational geometry,” in <i>Current Trends in Theoretical
    Computer Science, Essays and Tutorials</i>, World Scientific Publishing, 1993,
    pp. 1–48.
  ista: 'Edelsbrunner H. 1993.Computational geometry. In: Current Trends in Theoretical
    Computer Science, Essays and Tutorials. , 1–48.'
  mla: Edelsbrunner, Herbert. “Computational Geometry.” <i>Current Trends in Theoretical
    Computer Science, Essays and Tutorials</i>, World Scientific Publishing, 1993,
    pp. 1–48.
  short: H. Edelsbrunner, in:, Current Trends in Theoretical Computer Science, Essays
    and Tutorials, World Scientific Publishing, 1993, pp. 1–48.
date_created: 2018-12-11T12:04:01Z
date_published: 1993-08-01T00:00:00Z
date_updated: 2022-03-30T08:46:20Z
day: '01'
extern: '1'
language:
- iso: eng
main_file_link:
- url: https://books.google.at/books?hl=en&lr=&id=fr_sCgAAQBAJ&oi=fnd&pg=PR5&ots=XAust-LAGl&sig=FQTlA5rrM25y5EZ8ZmrorT7SaMo&redir_esc=y#v=onepage&q&f=false
month: '08'
oa_version: None
page: 1 - 48
publication: Current Trends in Theoretical Computer Science, Essays and Tutorials
publication_identifier:
  isbn:
  - 978-9810214623
publication_status: published
publisher: World Scientific Publishing
publist_id: '2816'
status: public
title: Computational geometry
type: book_chapter
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
year: '1993'
...
---
_id: '3643'
abstract:
- lang: eng
  text: 'We investigate the establishment and spread of new adaptive peaks within
    Wright''s ‘shifting balance’. The third phase of the ‘shifting balance’ involves
    a kind of group selection, since demes in which a superior peak has been established
    contain more individuals, and so send out more migrants. We assume that population
    size, N, increases with mean fitness, , according to the exponential relation,
    . Here, k is a measure of the weakness of density-dependent regulation, and equals
    the inverse of the regression of log (fitness) on log(N). In the island model,
    we find that just as with soft selection (k = 0), two distinct types of behaviour
    exist: group selection makes no qualitative difference. With low numbers of migrants,
    demes fluctuate almost independently, and only one equilibrium exists. With large
    numbers of migrants, all the demes evolve towards the same adaptive peak, and
    so the whole population can move towards one or other of the peaks. Group selection
    can be understood in terms of an effective mean fitness function. Its main consequence
    is to increase the effect of selection relative to drift (Ns), and so increase
    the bias towards the fitter peak. However, this increased bias depends on the
    ratio between k and the deme size (k/N), and so is very small when density-dependence
    is reasonably strong.'
acknowledgement: 'This work was supported by the Darwin Trust, by a Science and Engineering
  Research Council grant (GR/E/08507), and by an SERC Visiting Fellowship to S.Rouhani. '
article_processing_charge: No
article_type: original
author:
- first_name: Shahin
  full_name: Rouhani, Shahin
  last_name: Rouhani
- first_name: Nicholas H
  full_name: Barton, Nicholas H
  id: 4880FE40-F248-11E8-B48F-1D18A9856A87
  last_name: Barton
  orcid: 0000-0002-8548-5240
citation:
  ama: Rouhani S, Barton NH. Group selection and the “shifting balance.” <i>Genetical
    Research</i>. 1993;61(2):127-136. doi:<a href="https://doi.org/10.1017/S0016672300031232">10.1017/S0016672300031232</a>
  apa: Rouhani, S., &#38; Barton, N. H. (1993). Group selection and the “shifting
    balance.” <i>Genetical Research</i>. Cambridge University Press. <a href="https://doi.org/10.1017/S0016672300031232">https://doi.org/10.1017/S0016672300031232</a>
  chicago: Rouhani, Shahin, and Nicholas H Barton. “Group Selection and the ‘Shifting
    Balance.’” <i>Genetical Research</i>. Cambridge University Press, 1993. <a href="https://doi.org/10.1017/S0016672300031232">https://doi.org/10.1017/S0016672300031232</a>.
  ieee: S. Rouhani and N. H. Barton, “Group selection and the ‘shifting balance,’”
    <i>Genetical Research</i>, vol. 61, no. 2. Cambridge University Press, pp. 127–136,
    1993.
  ista: Rouhani S, Barton NH. 1993. Group selection and the ‘shifting balance’. Genetical
    Research. 61(2), 127–136.
  mla: Rouhani, Shahin, and Nicholas H. Barton. “Group Selection and the ‘Shifting
    Balance.’” <i>Genetical Research</i>, vol. 61, no. 2, Cambridge University Press,
    1993, pp. 127–36, doi:<a href="https://doi.org/10.1017/S0016672300031232">10.1017/S0016672300031232</a>.
  short: S. Rouhani, N.H. Barton, Genetical Research 61 (1993) 127–136.
date_created: 2018-12-11T12:04:24Z
date_published: 1993-04-01T00:00:00Z
date_updated: 2022-03-30T08:28:54Z
day: '01'
doi: 10.1017/S0016672300031232
extern: '1'
intvolume: '        61'
issue: '2'
language:
- iso: eng
main_file_link:
- url: https://www.cambridge.org/core/journals/genetics-research/article/group-selection-and-the-shifting-balance/CFDE26EA7125957545F9A0AA37755BC4
month: '04'
oa_version: None
page: 127 - 136
publication: Genetical Research
publication_identifier:
  issn:
  - 0016-6723
publication_status: published
publisher: Cambridge University Press
publist_id: '2740'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Group selection and the 'shifting balance'
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 61
year: '1993'
...
---
_id: '3644'
abstract:
- lang: eng
  text: "Wright proposed that there is a ' shifting balance' between selection within
    demes, random drift, and selection between demes at different 'adaptive peaks'.
    We investigate the establishment and spread of new adaptive peaks, considering
    a chromosome rearrangement, and a polygenic character under disruptive selection.
    When the number of migrants (Nm) is small, demes fluctuate independently, with
    a bias towards the fitter peak. When Nm is large, the whole population can\r\nmove
    to one of two stable equilibria, and so can be trapped near the lower peak. These
    two regimes are separated by a sharp transition at a critical Nm of order 1. Just
    below this critical point, adaptation is most efficient, since the shifting balance
    greatly increases the proportion of demes that reach the global optimum. This
    is so even if one peak is only slightly fitter than the other (AWx \\/N), and
    for both strong and weak selection (Ns <§ 1 or Ns > 1). Provided that Nm\r\nvaries
    sufficiently gradually from place to place, the fitter peak can be established
    in regions where Nm « 1, and can then spread through the rest of the range. Our
    analysis confirms Wright's argument that if selection, migration and drift are
    of the same order, the ' shifting balance' leads to efficient evolution towards
    the global optimum."
article_processing_charge: No
article_type: original
author:
- first_name: Nicholas H
  full_name: Barton, Nicholas H
  id: 4880FE40-F248-11E8-B48F-1D18A9856A87
  last_name: Barton
  orcid: 0000-0002-8548-5240
- first_name: Shahin
  full_name: Rouhani, Shahin
  last_name: Rouhani
citation:
  ama: Barton NH, Rouhani S. Adaptation and the “shifting balance.” <i>Genetical Research</i>.
    1993;61(1):57-74. doi:<a href="https://doi.org/10.1017/S0016672300031098 ">10.1017/S0016672300031098
    </a>
  apa: Barton, N. H., &#38; Rouhani, S. (1993). Adaptation and the “shifting balance.”
    <i>Genetical Research</i>. Cambridge University Press. <a href="https://doi.org/10.1017/S0016672300031098
    ">https://doi.org/10.1017/S0016672300031098 </a>
  chicago: Barton, Nicholas H, and Shahin Rouhani. “Adaptation and the ‘Shifting Balance.’”
    <i>Genetical Research</i>. Cambridge University Press, 1993. <a href="https://doi.org/10.1017/S0016672300031098
    ">https://doi.org/10.1017/S0016672300031098 </a>.
  ieee: N. H. Barton and S. Rouhani, “Adaptation and the ‘shifting balance,’” <i>Genetical
    Research</i>, vol. 61, no. 1. Cambridge University Press, pp. 57–74, 1993.
  ista: Barton NH, Rouhani S. 1993. Adaptation and the ‘shifting balance’. Genetical
    Research. 61(1), 57–74.
  mla: Barton, Nicholas H., and Shahin Rouhani. “Adaptation and the ‘Shifting Balance.’”
    <i>Genetical Research</i>, vol. 61, no. 1, Cambridge University Press, 1993, pp.
    57–74, doi:<a href="https://doi.org/10.1017/S0016672300031098 ">10.1017/S0016672300031098
    </a>.
  short: N.H. Barton, S. Rouhani, Genetical Research 61 (1993) 57–74.
date_created: 2018-12-11T12:04:24Z
date_published: 1993-02-01T00:00:00Z
date_updated: 2022-03-30T08:18:58Z
day: '01'
doi: '10.1017/S0016672300031098 '
extern: '1'
intvolume: '        61'
issue: '1'
language:
- iso: eng
main_file_link:
- url: https://www.cambridge.org/core/journals/genetics-research/article/adaptation-and-the-shifting-balance/2E15452B3AFCA97E77743E0C7E108064
month: '02'
oa_version: None
page: 57 - 74
publication: Genetical Research
publication_identifier:
  issn:
  - 0016-6723
publication_status: published
publisher: Cambridge University Press
publist_id: '2739'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Adaptation and the 'shifting balance'
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 61
year: '1993'
...
---
_id: '4036'
abstract:
- lang: eng
  text: This paper presents a randomized incremental algorithm for computing a single
    face in an arrangement of n line segments in the plane that is fairly simple to
    implement. The expected running time of the algorithm is O(nα(n)log n). The analysis
    of the algorithm uses a novel approach that generalizes and extends the Clarkson-Shor
    analysis technique [in Discrete Comput. Geom., 4(1989), pp. 387-421]. A few extensions
    of the technique, obtaining efficient randomized incremental algorithms for constructing
    the entire arrangement of a collection of line segments and for computing a single
    face in an arrangement of Jordan arcs are also presented.
acknowledgement: The authors wish to express their gratitude for the generous support
  and hospitality of the DEC Palo Alto Systems Research Center.
article_processing_charge: No
article_type: original
author:
- first_name: Bernard
  full_name: Chazelle, Bernard
  last_name: Chazelle
- first_name: Herbert
  full_name: Edelsbrunner, Herbert
  id: 3FB178DA-F248-11E8-B48F-1D18A9856A87
  last_name: Edelsbrunner
  orcid: 0000-0002-9823-6833
- first_name: Leonidas
  full_name: Guibas, Leonidas
  last_name: Guibas
- first_name: Micha
  full_name: Sharir, Micha
  last_name: Sharir
- first_name: Jack
  full_name: Snoeyink, Jack
  last_name: Snoeyink
citation:
  ama: Chazelle B, Edelsbrunner H, Guibas L, Sharir M, Snoeyink J. Computing a face
    in an arrangement of line segments and related problems. <i>SIAM Journal on Computing</i>.
    1993;22(6):1286-1302. doi:<a href="https://doi.org/10.1137/0222077 ">10.1137/0222077
    </a>
  apa: Chazelle, B., Edelsbrunner, H., Guibas, L., Sharir, M., &#38; Snoeyink, J.
    (1993). Computing a face in an arrangement of line segments and related problems.
    <i>SIAM Journal on Computing</i>. SIAM. <a href="https://doi.org/10.1137/0222077
    ">https://doi.org/10.1137/0222077 </a>
  chicago: Chazelle, Bernard, Herbert Edelsbrunner, Leonidas Guibas, Micha Sharir,
    and Jack Snoeyink. “Computing a Face in an Arrangement of Line Segments and Related
    Problems.” <i>SIAM Journal on Computing</i>. SIAM, 1993. <a href="https://doi.org/10.1137/0222077
    ">https://doi.org/10.1137/0222077 </a>.
  ieee: B. Chazelle, H. Edelsbrunner, L. Guibas, M. Sharir, and J. Snoeyink, “Computing
    a face in an arrangement of line segments and related problems,” <i>SIAM Journal
    on Computing</i>, vol. 22, no. 6. SIAM, pp. 1286–1302, 1993.
  ista: Chazelle B, Edelsbrunner H, Guibas L, Sharir M, Snoeyink J. 1993. Computing
    a face in an arrangement of line segments and related problems. SIAM Journal on
    Computing. 22(6), 1286–1302.
  mla: Chazelle, Bernard, et al. “Computing a Face in an Arrangement of Line Segments
    and Related Problems.” <i>SIAM Journal on Computing</i>, vol. 22, no. 6, SIAM,
    1993, pp. 1286–302, doi:<a href="https://doi.org/10.1137/0222077 ">10.1137/0222077
    </a>.
  short: B. Chazelle, H. Edelsbrunner, L. Guibas, M. Sharir, J. Snoeyink, SIAM Journal
    on Computing 22 (1993) 1286–1302.
date_created: 2018-12-11T12:06:34Z
date_published: 1993-12-01T00:00:00Z
date_updated: 2022-03-30T08:07:21Z
day: '01'
doi: '10.1137/0222077 '
extern: '1'
intvolume: '        22'
issue: '6'
language:
- iso: eng
main_file_link:
- url: https://epubs.siam.org/doi/10.1137/0222077
month: '12'
oa_version: None
page: 1286 - 1302
publication: SIAM Journal on Computing
publication_identifier:
  issn:
  - 0097-5397
publication_status: published
publisher: SIAM
publist_id: '2087'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Computing a face in an arrangement of line segments and related problems
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 22
year: '1993'
...
