---
_id: '2548'
abstract:
- lang: eng
text: The induction mechanism of cerebellar long term depression (LTD) has been
analysed in a cerebellar culture. Using nitr-5, a photolabile Ca chelator, we
demonstrated that an increase in postsynaptic Ca together with glutamate application
is sufficient to induce the LTD of glutamate responsiveness in Purkinje cells.
It has also been shown that one subtype of genetically defined metabotropic glutamate
receptor, mGluR1, is involved in the LTD induction. We raised antibodies which
specifically recognized mGluR1 and inactivated its function. The antibodies suppressed
the LTD induction in the cultured Purkinje cells.
alternative_title:
- Biomedical Research
author:
- first_name: Tomoo
full_name: Hirano, Tomoo
last_name: Hirano
- first_name: Keizo
full_name: Kasono, Keizo
last_name: Kasono
- first_name: Ryuichi
full_name: Ryuichi Shigemoto
id: 499F3ABC-F248-11E8-B48F-1D18A9856A87
last_name: Shigemoto
orcid: 0000-0001-8761-9444
- first_name: Shigetada
full_name: Nakanishi, Shigetada
last_name: Nakanishi
citation:
ama: 'Hirano T, Kasono K, Shigemoto R, Nakanishi S. Induction mechanism of long
term depression in cultured Purkinje neurons. In: Vol 15. Biomedical Research
Foundation; 1994:79-81.'
apa: Hirano, T., Kasono, K., Shigemoto, R., & Nakanishi, S. (1994). Induction
mechanism of long term depression in cultured Purkinje neurons (Vol. 15, pp. 79–81).
Presented at the Unknown (0388-6107), Biomedical Research Foundation.
chicago: Hirano, Tomoo, Keizo Kasono, Ryuichi Shigemoto, and Shigetada Nakanishi.
“Induction Mechanism of Long Term Depression in Cultured Purkinje Neurons,” 15:79–81.
Biomedical Research Foundation, 1994.
ieee: T. Hirano, K. Kasono, R. Shigemoto, and S. Nakanishi, “Induction mechanism
of long term depression in cultured Purkinje neurons,” presented at the Unknown
(0388-6107), 1994, vol. 15, no. SUPPL. 1, pp. 79–81.
ista: Hirano T, Kasono K, Shigemoto R, Nakanishi S. 1994. Induction mechanism of
long term depression in cultured Purkinje neurons. Unknown (0388-6107), Biomedical
Research, vol. 15, 79–81.
mla: Hirano, Tomoo, et al. Induction Mechanism of Long Term Depression in Cultured
Purkinje Neurons. Vol. 15, no. SUPPL. 1, Biomedical Research Foundation, 1994,
pp. 79–81.
short: T. Hirano, K. Kasono, R. Shigemoto, S. Nakanishi, in:, Biomedical Research
Foundation, 1994, pp. 79–81.
conference:
name: Unknown (0388-6107)
date_created: 2018-12-11T11:58:19Z
date_published: 1994-01-01T00:00:00Z
date_updated: 2021-01-12T06:58:10Z
day: '01'
extern: 1
intvolume: ' 15'
issue: SUPPL. 1
month: '01'
page: 79 - 81
publication_status: published
publisher: Biomedical Research Foundation
publist_id: '4350'
quality_controlled: 0
status: public
title: Induction mechanism of long term depression in cultured Purkinje neurons
type: conference
volume: 15
year: '1994'
...
---
_id: '2549'
abstract:
- lang: eng
text: In an attempt to reveal the function sites of substance P (SP) in the central
nervous system (CNS), the distribution of SP receptor (SPR) was immunocytochemically
investigated in adult rat and compared with that of SP- positive fibers. SPR-like
immunoreactivity (LI) was mostly localized to neuronal cell bodies and dendrites.
Neurons with intense SPR-LI were distributed densely in the cortical amygdaloid
nucleus, hilus of the dentate gyrus, locus ceruleus, rostral half of the ambiguus
nucleus, and intermediolateral nucleus of the thoracic cord; moderately in the
caudatoputamen, nucleus accumbens, olfactory tubercle, median, pontine, and magnus
raphe nuclei, laminae I and III of the caudal subnucleus of the spinal trigeminal
nucleus, and lamina I of the spinal cord; and sparsely in the cerebral cortex,
basal nucleus of Meynert, claustrum, gigantocellular reticular nucleus, and lobules
IX and X of the cerebellar vermis. Neurons with weak to moderate SPR-LI were distributed
more widely throughout the CNS. The regional patterns of distribution of SPR-LI
were not necessarily the same as those of SP-positive fibers. The entopeduncular
nucleus, substantia nigra, and lateral part of the interpeduncular nucleus showed
intense SP-LI but displayed almost no SPR-LI. Conversely, the hilus of the dentate
gyrus, anterodorsal thalamic nucleus, central nucleus of the inferior colliculus,
and dorsal tegmental nucleus showed intense to moderate SPR-LI but contained few
axons with SP-LI. These findings confirmed the presence of the 'mismatch' problem
between SP and SPR localizations. However, the distribution of SPR- LI was quite
consistent with that of the SP-binding activity, which has been studied via autoradiography.
This indicates that the sites of SPR-LI revealed in the present study represent
most, if not all, sites of SP-binding activity.
acknowledgement: 'We are grateful for photographic help of Mr. A. Uesugi and the support
of Drs. M. Arakawa, S. Fukuchi, T., Fukuda, R. Hayashi, S. Hayashi, S. Imai, M.
Katsurada, Y. Kitani, K. Kumagai, H. Kuroda, T. Kuroda, H. Matsubara, J. Matsuoka,
H. Matsushima, M. Nishio, G. Niwa, H. Oda, M. Ohbayashi, S. Ohbayashi, H. Ohtsuka,
S. Tamaki, E. Watanabe, and Y. Yoshino. This work was supported in part by Grants-in-Aid
for Scientific Research on Priority Areas 05248207 and 05267104 and Scientific Research
(B) 05454658 and (C) 05680658 from the Ministry of Education, Science and Culture
of Japan. '
article_processing_charge: No
article_type: original
author:
- first_name: Yoshifumi
full_name: Nakaya, Yoshifumi
last_name: Nakaya
- first_name: Takeshi
full_name: Kaneko, Takeshi
last_name: Kaneko
- first_name: Ryuichi
full_name: Shigemoto, Ryuichi
id: 499F3ABC-F248-11E8-B48F-1D18A9856A87
last_name: Shigemoto
orcid: 0000-0001-8761-9444
- first_name: Shigetada
full_name: Nakanishi, Shigetada
last_name: Nakanishi
- first_name: Noboru
full_name: Mizuno, Noboru
last_name: Mizuno
citation:
ama: Nakaya Y, Kaneko T, Shigemoto R, Nakanishi S, Mizuno N. Immunohistochemical
localization of substance P receptor in the central nervous system of the adult
rat. Journal of Comparative Neurology. 1994;347(2):249-274. doi:10.1002/cne.903470208
apa: Nakaya, Y., Kaneko, T., Shigemoto, R., Nakanishi, S., & Mizuno, N. (1994).
Immunohistochemical localization of substance P receptor in the central nervous
system of the adult rat. Journal of Comparative Neurology. Wiley-Blackwell.
https://doi.org/10.1002/cne.903470208
chicago: Nakaya, Yoshifumi, Takeshi Kaneko, Ryuichi Shigemoto, Shigetada Nakanishi,
and Noboru Mizuno. “Immunohistochemical Localization of Substance P Receptor in
the Central Nervous System of the Adult Rat.” Journal of Comparative Neurology.
Wiley-Blackwell, 1994. https://doi.org/10.1002/cne.903470208.
ieee: Y. Nakaya, T. Kaneko, R. Shigemoto, S. Nakanishi, and N. Mizuno, “Immunohistochemical
localization of substance P receptor in the central nervous system of the adult
rat,” Journal of Comparative Neurology, vol. 347, no. 2. Wiley-Blackwell,
pp. 249–274, 1994.
ista: Nakaya Y, Kaneko T, Shigemoto R, Nakanishi S, Mizuno N. 1994. Immunohistochemical
localization of substance P receptor in the central nervous system of the adult
rat. Journal of Comparative Neurology. 347(2), 249–274.
mla: Nakaya, Yoshifumi, et al. “Immunohistochemical Localization of Substance P
Receptor in the Central Nervous System of the Adult Rat.” Journal of Comparative
Neurology, vol. 347, no. 2, Wiley-Blackwell, 1994, pp. 249–74, doi:10.1002/cne.903470208.
short: Y. Nakaya, T. Kaneko, R. Shigemoto, S. Nakanishi, N. Mizuno, Journal of Comparative
Neurology 347 (1994) 249–274.
date_created: 2018-12-11T11:58:20Z
date_published: 1994-09-08T00:00:00Z
date_updated: 2022-06-09T09:25:30Z
day: '08'
doi: 10.1002/cne.903470208
extern: '1'
external_id:
pmid:
- '7814667'
intvolume: ' 347'
issue: '2'
language:
- iso: eng
main_file_link:
- url: https://onlinelibrary.wiley.com/doi/10.1002/cne.903470208
month: '09'
oa_version: None
page: 249 - 274
pmid: 1
publication: Journal of Comparative Neurology
publication_identifier:
issn:
- 0021-9967
publication_status: published
publisher: Wiley-Blackwell
publist_id: '4349'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Immunohistochemical localization of substance P receptor in the central nervous
system of the adult rat
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 347
year: '1994'
...
---
_id: '2550'
abstract:
- lang: eng
text: A cDNA clone for a new rat metabotropic glutamate receptor termed mGluR7 was
isolated through polymerase chain reaction-mediated DNA amplification by using
primer sequences conserved among the metabotropic receptor (mGluR) family and
by the subsequent screening of a rat forebrain cDNA library. The cloned mGluR7
subtype consists of 915 amino acid residues and exhibits a structural architecture
common to the mGluR family with a large extracellular domain preceding the seven
putative membrane-spanning domains. mGluR7 shows the highest sequence similarity
to mGluR4 and mGluR6 among the members of the mGluR family. Similar to mGluR4
and mGluR6, mGluR7 inhibits forskolin- stimulated cyclic AMP accumulation in response
to agonist interaction and potently reacts with L-2-amino-4-phosphonobutyrate
and L-serine-O-phosphate in Chinese hamster ovary cells transfected with the cloned
cDNA. RNA blot and in situ hybridization analyses of mGluR7 mRNA indicated that
it is widely expressed in many neuronal cells of the central nervous system and
is thus different from the more limitedly expressed mGluR4 or mGluR6 mRNA. mGluR7
together with mGluR4 thus corresponds to the putative L-2-amino-4- phosphonobutyrate
receptor which plays an important role in modulation of glutamate transmission
in the central nervous system.
acknowledgement: We are grateful to Akira Uesugi for photographic assistance.
article_processing_charge: No
author:
- first_name: Naoyuki
full_name: Okamoto, Naoyuki
last_name: Okamoto
- first_name: Seiji
full_name: Hori, Seiji
last_name: Hori
- first_name: Chihiro
full_name: Akazawa, Chihiro
last_name: Akazawa
- first_name: Yasunori
full_name: Hayashi, Yasunori
last_name: Hayashi
- first_name: Ryuichi
full_name: Shigemoto, Ryuichi
id: 499F3ABC-F248-11E8-B48F-1D18A9856A87
last_name: Shigemoto
orcid: 0000-0001-8761-9444
- first_name: Noboru
full_name: Mizuno, Noboru
last_name: Mizuno
- first_name: Shigetada
full_name: Nakanishi, Shigetada
last_name: Nakanishi
citation:
ama: Okamoto N, Hori S, Akazawa C, et al. Molecular characterization of a new metabotropic
glutamate receptor mGluR7 coupled to inhibitory cyclic AMP signal transduction.
Journal of Biological Chemistry. 1994;269(2):1231-1236. doi:10.1016/S0021-9258(17)42247-2
apa: Okamoto, N., Hori, S., Akazawa, C., Hayashi, Y., Shigemoto, R., Mizuno, N.,
& Nakanishi, S. (1994). Molecular characterization of a new metabotropic glutamate
receptor mGluR7 coupled to inhibitory cyclic AMP signal transduction. Journal
of Biological Chemistry. American Society for Biochemistry and Molecular Biology.
https://doi.org/10.1016/S0021-9258(17)42247-2
chicago: Okamoto, Naoyuki, Seiji Hori, Chihiro Akazawa, Yasunori Hayashi, Ryuichi
Shigemoto, Noboru Mizuno, and Shigetada Nakanishi. “Molecular Characterization
of a New Metabotropic Glutamate Receptor MGluR7 Coupled to Inhibitory Cyclic AMP
Signal Transduction.” Journal of Biological Chemistry. American Society
for Biochemistry and Molecular Biology, 1994. https://doi.org/10.1016/S0021-9258(17)42247-2.
ieee: N. Okamoto et al., “Molecular characterization of a new metabotropic
glutamate receptor mGluR7 coupled to inhibitory cyclic AMP signal transduction,”
Journal of Biological Chemistry, vol. 269, no. 2. American Society for
Biochemistry and Molecular Biology, pp. 1231–1236, 1994.
ista: Okamoto N, Hori S, Akazawa C, Hayashi Y, Shigemoto R, Mizuno N, Nakanishi
S. 1994. Molecular characterization of a new metabotropic glutamate receptor mGluR7
coupled to inhibitory cyclic AMP signal transduction. Journal of Biological Chemistry.
269(2), 1231–1236.
mla: Okamoto, Naoyuki, et al. “Molecular Characterization of a New Metabotropic
Glutamate Receptor MGluR7 Coupled to Inhibitory Cyclic AMP Signal Transduction.”
Journal of Biological Chemistry, vol. 269, no. 2, American Society for
Biochemistry and Molecular Biology, 1994, pp. 1231–36, doi:10.1016/S0021-9258(17)42247-2.
short: N. Okamoto, S. Hori, C. Akazawa, Y. Hayashi, R. Shigemoto, N. Mizuno, S.
Nakanishi, Journal of Biological Chemistry 269 (1994) 1231–1236.
date_created: 2018-12-11T11:58:20Z
date_published: 1994-01-14T00:00:00Z
date_updated: 2022-06-08T15:11:44Z
day: '14'
doi: 10.1016/S0021-9258(17)42247-2
extern: '1'
external_id:
pmid:
- '8288585'
intvolume: ' 269'
issue: '2'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://www.sciencedirect.com/science/article/pii/S0021925817422472?via%3Dihub
month: '01'
oa: 1
oa_version: None
page: 1231 - 1236
pmid: 1
publication: Journal of Biological Chemistry
publication_status: published
publisher: American Society for Biochemistry and Molecular Biology
publist_id: '4348'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Molecular characterization of a new metabotropic glutamate receptor mGluR7
coupled to inhibitory cyclic AMP signal transduction
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 269
year: '1994'
...
---
_id: '2551'
abstract:
- lang: eng
text: Expression patterns of mRNAs of l-AP4-sensitive metabotropic glutamate receptors
(mGluR4, mGluR6, mGluR7) in the rat retina were examined by northern blot analysis
and in situ hybridization histochemistry. Expression patterns of mGluR4 and mGluR7
mRNAs were quite different from that of mGluR6 mRNA which was expressed at the
outer part of the inner nuclear layer. The mGluR4 mRNA was expressed on the cell
bodies of the ganglion cells, but not in the inner or outer nuclear layer. The
expression of mGluR7 mRNA was observed throughout the entire region of the inner
nuclear layer and on the cell bodies of the ganglion cells.
acknowledgement: The photographic help of Mr. Akira Uesugi is gratefully acknowledged.
This work has been supported by research grants from the Ministry of Education,
Science and Culture of Japan.
article_processing_charge: No
article_type: original
author:
- first_name: Chihiro
full_name: Akazawa, Chihiro
last_name: Akazawa
- first_name: Hitoshi
full_name: Ohishi, Hitoshi
last_name: Ohishi
- first_name: Yoshiaki
full_name: Nakajima, Yoshiaki
last_name: Nakajima
- first_name: Naoyuki
full_name: Okamoto, Naoyuki
last_name: Okamoto
- first_name: Ryuichi
full_name: Shigemoto, Ryuichi
id: 499F3ABC-F248-11E8-B48F-1D18A9856A87
last_name: Shigemoto
orcid: 0000-0001-8761-9444
- first_name: Shigetada
full_name: Nakanishi, Shigetada
last_name: Nakanishi
- first_name: Noboru
full_name: Mizuno, Noboru
last_name: Mizuno
citation:
ama: Akazawa C, Ohishi H, Nakajima Y, et al. Expression of mRNAs of l-AP4-sensitive
metabotropic glutamate receptors (mGluR4, mGluR6, mGluR7) in the rat retina. Neuroscience
Letters. 1994;171(1-2):52-54. doi:10.1016/0304-3940(94)90602-5
apa: Akazawa, C., Ohishi, H., Nakajima, Y., Okamoto, N., Shigemoto, R., Nakanishi,
S., & Mizuno, N. (1994). Expression of mRNAs of l-AP4-sensitive metabotropic
glutamate receptors (mGluR4, mGluR6, mGluR7) in the rat retina. Neuroscience
Letters. Elsevier. https://doi.org/10.1016/0304-3940(94)90602-5
chicago: Akazawa, Chihiro, Hitoshi Ohishi, Yoshiaki Nakajima, Naoyuki Okamoto, Ryuichi
Shigemoto, Shigetada Nakanishi, and Noboru Mizuno. “Expression of MRNAs of L-AP4-Sensitive
Metabotropic Glutamate Receptors (MGluR4, MGluR6, MGluR7) in the Rat Retina.”
Neuroscience Letters. Elsevier, 1994. https://doi.org/10.1016/0304-3940(94)90602-5.
ieee: C. Akazawa et al., “Expression of mRNAs of l-AP4-sensitive metabotropic
glutamate receptors (mGluR4, mGluR6, mGluR7) in the rat retina,” Neuroscience
Letters, vol. 171, no. 1–2. Elsevier, pp. 52–54, 1994.
ista: Akazawa C, Ohishi H, Nakajima Y, Okamoto N, Shigemoto R, Nakanishi S, Mizuno
N. 1994. Expression of mRNAs of l-AP4-sensitive metabotropic glutamate receptors
(mGluR4, mGluR6, mGluR7) in the rat retina. Neuroscience Letters. 171(1–2), 52–54.
mla: Akazawa, Chihiro, et al. “Expression of MRNAs of L-AP4-Sensitive Metabotropic
Glutamate Receptors (MGluR4, MGluR6, MGluR7) in the Rat Retina.” Neuroscience
Letters, vol. 171, no. 1–2, Elsevier, 1994, pp. 52–54, doi:10.1016/0304-3940(94)90602-5.
short: C. Akazawa, H. Ohishi, Y. Nakajima, N. Okamoto, R. Shigemoto, S. Nakanishi,
N. Mizuno, Neuroscience Letters 171 (1994) 52–54.
date_created: 2018-12-11T11:58:21Z
date_published: 1994-04-25T00:00:00Z
date_updated: 2022-06-08T14:02:11Z
day: '25'
doi: 10.1016/0304-3940(94)90602-5
extern: '1'
external_id:
pmid:
- '8084499'
intvolume: ' 171'
issue: 1-2
language:
- iso: eng
main_file_link:
- url: https://www.sciencedirect.com/science/article/pii/0304394094906025?via%3Dihub
month: '04'
oa_version: None
page: 52 - 54
pmid: 1
publication: Neuroscience Letters
publication_identifier:
issn:
- 0304-3940
publication_status: published
publisher: Elsevier
publist_id: '4346'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Expression of mRNAs of l-AP4-sensitive metabotropic glutamate receptors (mGluR4,
mGluR6, mGluR7) in the rat retina
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 171
year: '1994'
...
---
_id: '2552'
abstract:
- lang: eng
text: The superficial layers of the superior colliculus (SC) have been known to
contain many axons showing substance P-like immunoreactivity (SP-LI). We, therefore,
immunohistochemically examined the distribution of SP receptor (SPR) in the superficial
layers of the SC in the rat by using a specific antibody against SPR. The majority
of SC neurons with SPR-LI were distributed in the zonal and the superficial gray
layers, the rest of them were in the optic layer. Electron microscopy revealed
that SPR-immunoreaction products in SC neurons were distributed not only in postsynaptic
sites, but also in non-synaptic regions of perikaryal and dendritic profiles.
acknowledgement: The authors are grateful for photographic help of Mr. Akira Uesugi.
article_processing_charge: No
article_type: original
author:
- first_name: Reiko
full_name: Ogawa Meguro, Reiko
last_name: Ogawa Meguro
- first_name: Ryuichi
full_name: Shigemoto, Ryuichi
id: 499F3ABC-F248-11E8-B48F-1D18A9856A87
last_name: Shigemoto
orcid: 0000-0001-8761-9444
- first_name: Kazuo
full_name: Itoh, Kazuo
last_name: Itoh
- first_name: Akira
full_name: Konishi, Akira
last_name: Konishi
- first_name: Noboru
full_name: Mizuno, Noboru
last_name: Mizuno
citation:
ama: Ogawa Meguro R, Shigemoto R, Itoh K, Konishi A, Mizuno N. Immunohistochemical
localization of substance P receptor in the superior colliculus. A light and electron
microscope study in the rat. Neuroscience Letters. 1994;166(2):135-138.
doi:10.1016/0304-3940(94)90469-3
apa: Ogawa Meguro, R., Shigemoto, R., Itoh, K., Konishi, A., & Mizuno, N. (1994).
Immunohistochemical localization of substance P receptor in the superior colliculus.
A light and electron microscope study in the rat. Neuroscience Letters.
Elsevier. https://doi.org/10.1016/0304-3940(94)90469-3
chicago: Ogawa Meguro, Reiko, Ryuichi Shigemoto, Kazuo Itoh, Akira Konishi, and
Noboru Mizuno. “Immunohistochemical Localization of Substance P Receptor in the
Superior Colliculus. A Light and Electron Microscope Study in the Rat.” Neuroscience
Letters. Elsevier, 1994. https://doi.org/10.1016/0304-3940(94)90469-3.
ieee: R. Ogawa Meguro, R. Shigemoto, K. Itoh, A. Konishi, and N. Mizuno, “Immunohistochemical
localization of substance P receptor in the superior colliculus. A light and electron
microscope study in the rat,” Neuroscience Letters, vol. 166, no. 2. Elsevier,
pp. 135–138, 1994.
ista: Ogawa Meguro R, Shigemoto R, Itoh K, Konishi A, Mizuno N. 1994. Immunohistochemical
localization of substance P receptor in the superior colliculus. A light and electron
microscope study in the rat. Neuroscience Letters. 166(2), 135–138.
mla: Ogawa Meguro, Reiko, et al. “Immunohistochemical Localization of Substance
P Receptor in the Superior Colliculus. A Light and Electron Microscope Study in
the Rat.” Neuroscience Letters, vol. 166, no. 2, Elsevier, 1994, pp. 135–38,
doi:10.1016/0304-3940(94)90469-3.
short: R. Ogawa Meguro, R. Shigemoto, K. Itoh, A. Konishi, N. Mizuno, Neuroscience
Letters 166 (1994) 135–138.
date_created: 2018-12-11T11:58:21Z
date_published: 1994-01-31T00:00:00Z
date_updated: 2022-06-08T14:37:30Z
day: '31'
doi: 10.1016/0304-3940(94)90469-3
extern: '1'
external_id:
pmid:
- '8177489'
intvolume: ' 166'
issue: '2'
language:
- iso: eng
main_file_link:
- url: https://www.sciencedirect.com/science/article/pii/0304394094904693?via%3Dihub
month: '01'
oa_version: None
page: 135 - 138
pmid: 1
publication: Neuroscience Letters
publication_identifier:
issn:
- 0304-3940
publication_status: published
publisher: Elsevier
publist_id: '4347'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Immunohistochemical localization of substance P receptor in the superior colliculus.
A light and electron microscope study in the rat
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 166
year: '1994'
...
---
_id: '2553'
abstract:
- lang: eng
text: Distribution of the mRNAs for three subtypes of prostaglandin E (PGE) receptors
in the mouse kidney was investigated by in situ hybridization. The mRNA for EP1
subtype, which is coupled to Ca2+ mobilization, was specifically localized to
the collecting ducts from the cortex to the papilla. The mRNA for EP2 subtype,
which is linked to stimulation of adenylate cyclase, was localized to the glomeruli.
The mRNA for EP3 subtype, which is coupled to inhibition of adenylate cyclase,
was located densely in the tubules in the outer medulla and in the distal tubules
in the cortex. These results exhibit distinct cellular localization of three subtypes
of PGE receptor in the kidney and suggest that PGE2 exerts multiple functions
via these subtypes expressed in different segments of the nephron.
acknowledgement: We thank Drs. Noboru Mizuno, Tsuyoshi Watanabe, Akihide Nakao, Chihiro
Akazawa, and Akira Uesugi for invaluable discussions and photographic support. This
work was supported in part by Scientific Research Grants-inAid 05404020, 04255103,
05771975, 05671816, and 05454568 from the Ministry of Education, Science and Culture
of Japan and by grants from the Mitsubishi Foundation and the Takeda Science Foundation.
article_processing_charge: No
article_type: original
author:
- first_name: Yukihiko
full_name: Sugimoto, Yukihiko
last_name: Sugimoto
- first_name: Tsunehisa
full_name: Namba, Tsunehisa
last_name: Namba
- first_name: Ryuichi
full_name: Shigemoto, Ryuichi
id: 499F3ABC-F248-11E8-B48F-1D18A9856A87
last_name: Shigemoto
orcid: 0000-0001-8761-9444
- first_name: Manabu
full_name: Negishi, Manabu
last_name: Negishi
- first_name: Atsushi
full_name: Ichikawa, Atsushi
last_name: Ichikawa
- first_name: Shuh
full_name: Narumiya, Shuh
last_name: Narumiya
citation:
ama: Sugimoto Y, Namba T, Shigemoto R, Negishi M, Ichikawa A, Narumiya S. Distinct
cellular localization of mRNAs for three subtypes of prostaglandin E receptor
in kidney. American Journal of Physiology. 1994;266(5):F823-F828. doi:10.1152/ajprenal.1994.266.5.F823
apa: Sugimoto, Y., Namba, T., Shigemoto, R., Negishi, M., Ichikawa, A., & Narumiya,
S. (1994). Distinct cellular localization of mRNAs for three subtypes of prostaglandin
E receptor in kidney. American Journal of Physiology. American Physiological
Society. https://doi.org/10.1152/ajprenal.1994.266.5.F823
chicago: Sugimoto, Yukihiko, Tsunehisa Namba, Ryuichi Shigemoto, Manabu Negishi,
Atsushi Ichikawa, and Shuh Narumiya. “Distinct Cellular Localization of MRNAs
for Three Subtypes of Prostaglandin E Receptor in Kidney.” American Journal
of Physiology. American Physiological Society, 1994. https://doi.org/10.1152/ajprenal.1994.266.5.F823.
ieee: Y. Sugimoto, T. Namba, R. Shigemoto, M. Negishi, A. Ichikawa, and S. Narumiya,
“Distinct cellular localization of mRNAs for three subtypes of prostaglandin E
receptor in kidney,” American Journal of Physiology, vol. 266, no. 5. American
Physiological Society, pp. F823–F828, 1994.
ista: Sugimoto Y, Namba T, Shigemoto R, Negishi M, Ichikawa A, Narumiya S. 1994.
Distinct cellular localization of mRNAs for three subtypes of prostaglandin E
receptor in kidney. American Journal of Physiology. 266(5), F823–F828.
mla: Sugimoto, Yukihiko, et al. “Distinct Cellular Localization of MRNAs for Three
Subtypes of Prostaglandin E Receptor in Kidney.” American Journal of Physiology,
vol. 266, no. 5, American Physiological Society, 1994, pp. F823–28, doi:10.1152/ajprenal.1994.266.5.F823.
short: Y. Sugimoto, T. Namba, R. Shigemoto, M. Negishi, A. Ichikawa, S. Narumiya,
American Journal of Physiology 266 (1994) F823–F828.
date_created: 2018-12-11T11:58:21Z
date_published: 1994-05-01T00:00:00Z
date_updated: 2022-06-07T15:03:51Z
day: '01'
doi: 10.1152/ajprenal.1994.266.5.F823
extern: '1'
external_id:
pmid:
- '8203567'
intvolume: ' 266'
issue: '5'
language:
- iso: eng
main_file_link:
- url: https://journals.physiology.org/doi/abs/10.1152/ajprenal.1994.266.5.F823
month: '05'
oa_version: None
page: F823 - F828
pmid: 1
publication: American Journal of Physiology
publication_identifier:
issn:
- 0363-6127
publication_status: published
publisher: American Physiological Society
publist_id: '4345'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Distinct cellular localization of mRNAs for three subtypes of prostaglandin
E receptor in kidney
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 266
year: '1994'
...
---
_id: '2554'
abstract:
- lang: eng
text: 'The retinal bipolar cell receiving glutamate transmission from photoreceptors
mediates a key process in segregating visual signals into ON center and OFF center
pathways. This transmission involves a G protein- coupled metabotropic glutamate
receptor (mGluR). Immunocytochemical and immunoelectron microscopic studies indicate
the restricted localization of a specific mGluR subtype, mGluR6, at the postsynaptic
site of the rat rod bipolar cell. This specialization is developmentally regulated:
mGluR6 is initially distributed in both the soma and dendrites and is finally
concentrated on the postsynaptic site. The mGluR6 localization is reversed when
photoreceptors degenerate in the mutant rat with retinal dystrophy. Evidence is
thus presented indicating specialized, developmentally regulated receptor distribution
in the central nervous system and the crucial role of mGluR6 in photoreceptor-bipolar
cell synaptic transmission.'
acknowledgement: "We thank M. Tachibana for technical advice concerning dissociated
bipolar cell preparation, Y. Honda for advice \r\nconcerning RCS rat experiments,
and A. Uesugi for photographic assistance. This work is partly supported by research
grants from the Ministry of Education, Science, and Culture of Japan and from the
Ministry of Health and Welfare of\r\nJapan. "
article_processing_charge: No
article_type: original
author:
- first_name: Akinori
full_name: Nomura, Akinori
last_name: Nomura
- first_name: Ryuichi
full_name: Shigemoto, Ryuichi
id: 499F3ABC-F248-11E8-B48F-1D18A9856A87
last_name: Shigemoto
orcid: 0000-0001-8761-9444
- first_name: Yasuhisa
full_name: Nakamura, Yasuhisa
last_name: Nakamura
- first_name: Naoyuki
full_name: Okamoto, Naoyuki
last_name: Okamoto
- first_name: Noboru
full_name: Mizuno, Noboru
last_name: Mizuno
- first_name: Shigetada
full_name: Nakanishi, Shigetada
last_name: Nakanishi
citation:
ama: Nomura A, Shigemoto R, Nakamura Y, Okamoto N, Mizuno N, Nakanishi S. Developmentally
regulated postsynaptic localization of a metabotropic glutamate receptor in rat
rod bipolar cells. Cell. 1994;77(3):361-369. doi:10.1016/0092-8674(94)90151-1
apa: Nomura, A., Shigemoto, R., Nakamura, Y., Okamoto, N., Mizuno, N., & Nakanishi,
S. (1994). Developmentally regulated postsynaptic localization of a metabotropic
glutamate receptor in rat rod bipolar cells. Cell. Cell Press. https://doi.org/10.1016/0092-8674(94)90151-1
chicago: Nomura, Akinori, Ryuichi Shigemoto, Yasuhisa Nakamura, Naoyuki Okamoto,
Noboru Mizuno, and Shigetada Nakanishi. “Developmentally Regulated Postsynaptic
Localization of a Metabotropic Glutamate Receptor in Rat Rod Bipolar Cells.” Cell.
Cell Press, 1994. https://doi.org/10.1016/0092-8674(94)90151-1.
ieee: A. Nomura, R. Shigemoto, Y. Nakamura, N. Okamoto, N. Mizuno, and S. Nakanishi,
“Developmentally regulated postsynaptic localization of a metabotropic glutamate
receptor in rat rod bipolar cells,” Cell, vol. 77, no. 3. Cell Press, pp.
361–369, 1994.
ista: Nomura A, Shigemoto R, Nakamura Y, Okamoto N, Mizuno N, Nakanishi S. 1994.
Developmentally regulated postsynaptic localization of a metabotropic glutamate
receptor in rat rod bipolar cells. Cell. 77(3), 361–369.
mla: Nomura, Akinori, et al. “Developmentally Regulated Postsynaptic Localization
of a Metabotropic Glutamate Receptor in Rat Rod Bipolar Cells.” Cell, vol.
77, no. 3, Cell Press, 1994, pp. 361–69, doi:10.1016/0092-8674(94)90151-1.
short: A. Nomura, R. Shigemoto, Y. Nakamura, N. Okamoto, N. Mizuno, S. Nakanishi,
Cell 77 (1994) 361–369.
date_created: 2018-12-11T11:58:21Z
date_published: 1994-05-06T00:00:00Z
date_updated: 2022-06-07T14:28:33Z
day: '06'
doi: 10.1016/0092-8674(94)90151-1
extern: '1'
external_id:
pmid:
- '8181056'
intvolume: ' 77'
issue: '3'
language:
- iso: eng
main_file_link:
- url: https://www.sciencedirect.com/science/article/pii/0092867494901511?via%3Dihub
month: '05'
oa_version: None
page: 361 - 369
pmid: 1
publication: Cell
publication_identifier:
issn:
- 0092-8674
publication_status: published
publisher: Cell Press
publist_id: '4344'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Developmentally regulated postsynaptic localization of a metabotropic glutamate
receptor in rat rod bipolar cells
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 77
year: '1994'
...
---
_id: '2555'
abstract:
- lang: eng
text: Antibodies were raised against two distinct extracellular sequences of the
rat mGluR1 metabotropic glutamate receptor expressed as bacterial fusion proteins.
Both antibodies specifically reacted with mGluR1 in the rat cerebellum and inhibited
the mGluR1 activity as assessed by the analysis of glutamate-stimulated inositol
phosphate formation in CHO cells expressing mGluR1. Using these antibodies, we
examined the role of mGluR1 in the induction of long-term depression in cultured
Purkinje cells. In voltage- clamped Purkinje cells, current induced by iontophoretically
applied glutamate was persistently depressed by depolarization of the Purkinje
cells in conjunction with the glutamate application. The mGluR1 antibodies completely
blocked the depression of glutamate-induced current. The results indicate that
activation of mGluR1 is necessary for the induction of cerebellar long-term depression
and that these mGluR1 antibodies can be used as selective antagonists.
acknowledgement: 'Correspondence should be addressed to R. S. The photographic help
of Mr. Akira Uesugi is gratefully acknowledged. This work has been supported by
research grants from Senri Life Science Foundation, the Brain Science Foundation,
the Narishige Foundation, and the Ministry of Education, Science, and Culture of
Japan. The costs of publication of this article were defrayed in part by the payment
of page charges. This article must therefore be hereby marked "advertisement” in
accordance with 18 USC Section 1734 solely to indicate this fact. '
article_processing_charge: No
article_type: original
author:
- first_name: Ryuichi
full_name: Shigemoto, Ryuichi
id: 499F3ABC-F248-11E8-B48F-1D18A9856A87
last_name: Shigemoto
orcid: 0000-0001-8761-9444
- first_name: Takaaki
full_name: Abe, Takaaki
last_name: Abe
- first_name: Sakashi
full_name: Nomura, Sakashi
last_name: Nomura
- first_name: Shigetada
full_name: Nakanishi, Shigetada
last_name: Nakanishi
- first_name: Tomoo
full_name: Hirano, Tomoo
last_name: Hirano
citation:
ama: Shigemoto R, Abe T, Nomura S, Nakanishi S, Hirano T. Antibodies inactivating
mGluR1 metabotropic glutamate receptor block long-term depression in cultured
Purkinje cells. Neuron. 1994;12(6):1245-1255. doi:10.1016/0896-6273(94)90441-3
apa: Shigemoto, R., Abe, T., Nomura, S., Nakanishi, S., & Hirano, T. (1994).
Antibodies inactivating mGluR1 metabotropic glutamate receptor block long-term
depression in cultured Purkinje cells. Neuron. Elsevier. https://doi.org/10.1016/0896-6273(94)90441-3
chicago: Shigemoto, Ryuichi, Takaaki Abe, Sakashi Nomura, Shigetada Nakanishi, and
Tomoo Hirano. “Antibodies Inactivating MGluR1 Metabotropic Glutamate Receptor
Block Long-Term Depression in Cultured Purkinje Cells.” Neuron. Elsevier,
1994. https://doi.org/10.1016/0896-6273(94)90441-3.
ieee: R. Shigemoto, T. Abe, S. Nomura, S. Nakanishi, and T. Hirano, “Antibodies
inactivating mGluR1 metabotropic glutamate receptor block long-term depression
in cultured Purkinje cells,” Neuron, vol. 12, no. 6. Elsevier, pp. 1245–1255,
1994.
ista: Shigemoto R, Abe T, Nomura S, Nakanishi S, Hirano T. 1994. Antibodies inactivating
mGluR1 metabotropic glutamate receptor block long-term depression in cultured
Purkinje cells. Neuron. 12(6), 1245–1255.
mla: Shigemoto, Ryuichi, et al. “Antibodies Inactivating MGluR1 Metabotropic Glutamate
Receptor Block Long-Term Depression in Cultured Purkinje Cells.” Neuron,
vol. 12, no. 6, Elsevier, 1994, pp. 1245–55, doi:10.1016/0896-6273(94)90441-3.
short: R. Shigemoto, T. Abe, S. Nomura, S. Nakanishi, T. Hirano, Neuron 12 (1994)
1245–1255.
date_created: 2018-12-11T11:58:22Z
date_published: 1994-06-01T00:00:00Z
date_updated: 2022-06-07T13:39:09Z
day: '01'
doi: 10.1016/0896-6273(94)90441-3
extern: '1'
external_id:
pmid:
- '7912091 '
intvolume: ' 12'
issue: '6'
language:
- iso: eng
main_file_link:
- url: https://www.sciencedirect.com/science/article/pii/0896627394904413?via%3Dihub
month: '06'
oa_version: None
page: 1245 - 1255
pmid: 1
publication: Neuron
publication_identifier:
issn:
- 0896-6273
publication_status: published
publisher: Elsevier
publist_id: '4343'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Antibodies inactivating mGluR1 metabotropic glutamate receptor block long-term
depression in cultured Purkinje cells
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 12
year: '1994'
...
---
_id: '2557'
abstract:
- lang: eng
text: The distribution of the metabotropic glutamate receptors mGluR2 and mGluR3
was immunohistochemically examined in the rat cerebellar cortex at both light
and electron microscope levels. An antibody was raised against a fusion protein
containing a C-terminal portion of mGluR2. On immunoblot, the antibody reacted
with both mGluR2 and mGluR3 in rat brain. mGluR2/3 immunoreactivity was expressed
in cell bodies, dendrites, and axon terminals of Golgi cells, as well as in presumed
glial processes. Golgi axon terminals with mGluR2/3 immunoreactivity were often
encountered in the vicinity of glutamatergic mossy fiber terminals. The results
suggest that transmitter glutamate may exert control influences upon Golgi cells
not only through dendritic mGluR2/3, but also through axonal mGluR2/3.
acknowledgement: "We are grateful to Mr. Akira Uesugi for photographic help. This
work has been supported in part by research grants from the Ministry of Education,
Science and Culture of Japan. The costs of publication of this article were defrayed
in part\r\nby the payment of page charges. This article must therefore be hereby
marked “advertisement” in accordance with 18 USC Section 1734 solely to indicate
this fact. "
article_processing_charge: No
article_type: original
author:
- first_name: Hitoshi
full_name: Ohishi, Hitoshi
last_name: Ohishi
- first_name: Reiko
full_name: Ogawa Meguro, Reiko
last_name: Ogawa Meguro
- first_name: Ryuichi
full_name: Shigemoto, Ryuichi
id: 499F3ABC-F248-11E8-B48F-1D18A9856A87
last_name: Shigemoto
orcid: 0000-0001-8761-9444
- first_name: Takeshi
full_name: Kaneko, Takeshi
last_name: Kaneko
- first_name: Shigetada
full_name: Nakanishi, Shigetada
last_name: Nakanishi
- first_name: Noboru
full_name: Mizuno, Noboru
last_name: Mizuno
citation:
ama: Ohishi H, Ogawa Meguro R, Shigemoto R, Kaneko T, Nakanishi S, Mizuno N. Immunohistochemical
localization of metabotropic glutamate receptors, mGluR2 and mGluR3, in rat cerebellar
cortex. Neuron. 1994;13(1):55-66. doi:10.1016/0896-6273(94)90459-6
apa: Ohishi, H., Ogawa Meguro, R., Shigemoto, R., Kaneko, T., Nakanishi, S., &
Mizuno, N. (1994). Immunohistochemical localization of metabotropic glutamate
receptors, mGluR2 and mGluR3, in rat cerebellar cortex. Neuron. Elsevier.
https://doi.org/10.1016/0896-6273(94)90459-6
chicago: Ohishi, Hitoshi, Reiko Ogawa Meguro, Ryuichi Shigemoto, Takeshi Kaneko,
Shigetada Nakanishi, and Noboru Mizuno. “Immunohistochemical Localization of Metabotropic
Glutamate Receptors, MGluR2 and MGluR3, in Rat Cerebellar Cortex.” Neuron.
Elsevier, 1994. https://doi.org/10.1016/0896-6273(94)90459-6.
ieee: H. Ohishi, R. Ogawa Meguro, R. Shigemoto, T. Kaneko, S. Nakanishi, and N.
Mizuno, “Immunohistochemical localization of metabotropic glutamate receptors,
mGluR2 and mGluR3, in rat cerebellar cortex,” Neuron, vol. 13, no. 1. Elsevier,
pp. 55–66, 1994.
ista: Ohishi H, Ogawa Meguro R, Shigemoto R, Kaneko T, Nakanishi S, Mizuno N. 1994.
Immunohistochemical localization of metabotropic glutamate receptors, mGluR2 and
mGluR3, in rat cerebellar cortex. Neuron. 13(1), 55–66.
mla: Ohishi, Hitoshi, et al. “Immunohistochemical Localization of Metabotropic Glutamate
Receptors, MGluR2 and MGluR3, in Rat Cerebellar Cortex.” Neuron, vol. 13,
no. 1, Elsevier, 1994, pp. 55–66, doi:10.1016/0896-6273(94)90459-6.
short: H. Ohishi, R. Ogawa Meguro, R. Shigemoto, T. Kaneko, S. Nakanishi, N. Mizuno,
Neuron 13 (1994) 55–66.
date_created: 2018-12-11T11:58:22Z
date_published: 1994-07-01T00:00:00Z
date_updated: 2022-06-07T13:21:58Z
day: '01'
doi: 10.1016/0896-6273(94)90459-6
extern: '1'
external_id:
pmid:
- '8043281'
intvolume: ' 13'
issue: '1'
language:
- iso: eng
main_file_link:
- url: https://www.sciencedirect.com/science/article/pii/0896627394904596?via%3Dihub
month: '07'
oa_version: None
page: 55 - 66
pmid: 1
publication: Neuron
publication_identifier:
issn:
- 0896-6273
publication_status: published
publisher: Elsevier
publist_id: '4342'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Immunohistochemical localization of metabotropic glutamate receptors, mGluR2
and mGluR3, in rat cerebellar cortex
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 13
year: '1994'
...
---
_id: '2713'
acknowledgement: Work supported by the NSF grant PHY90-19433 A02 and by the Alfred
Sloan Foundation dissertation fellowship.
article_processing_charge: No
article_type: original
author:
- first_name: László
full_name: Erdös, László
id: 4DBD5372-F248-11E8-B48F-1D18A9856A87
last_name: Erdös
orcid: 0000-0001-5366-9603
citation:
ama: Erdös L. Estimates on stochastic oscillatory integrals and on the heat kernel
of the magnetic Schrödinger operator. Duke Mathematical Journal. 1994;76(2):541-566.
doi:10.1215/S0012-7094-94-07619-9
apa: Erdös, L. (1994). Estimates on stochastic oscillatory integrals and on the
heat kernel of the magnetic Schrödinger operator. Duke Mathematical Journal.
Duke University Press. https://doi.org/10.1215/S0012-7094-94-07619-9
chicago: Erdös, László. “Estimates on Stochastic Oscillatory Integrals and on the
Heat Kernel of the Magnetic Schrödinger Operator.” Duke Mathematical Journal.
Duke University Press, 1994. https://doi.org/10.1215/S0012-7094-94-07619-9.
ieee: L. Erdös, “Estimates on stochastic oscillatory integrals and on the heat kernel
of the magnetic Schrödinger operator,” Duke Mathematical Journal, vol.
76, no. 2. Duke University Press, pp. 541–566, 1994.
ista: Erdös L. 1994. Estimates on stochastic oscillatory integrals and on the heat
kernel of the magnetic Schrödinger operator. Duke Mathematical Journal. 76(2),
541–566.
mla: Erdös, László. “Estimates on Stochastic Oscillatory Integrals and on the Heat
Kernel of the Magnetic Schrödinger Operator.” Duke Mathematical Journal,
vol. 76, no. 2, Duke University Press, 1994, pp. 541–66, doi:10.1215/S0012-7094-94-07619-9.
short: L. Erdös, Duke Mathematical Journal 76 (1994) 541–566.
date_created: 2018-12-11T11:59:13Z
date_published: 1994-11-01T00:00:00Z
date_updated: 2022-06-03T11:59:06Z
day: '01'
doi: 10.1215/S0012-7094-94-07619-9
extern: '1'
intvolume: ' 76'
issue: '2'
language:
- iso: eng
main_file_link:
- url: https://projecteuclid.org/journals/duke-mathematical-journal/volume-76/issue-2/Estimates-on-stochastic-oscillatory-integrals-and-on-the-heat-kernel/10.1215/S0012-7094-94-07619-9.short
month: '11'
oa_version: None
page: 541 - 566
publication: Duke Mathematical Journal
publication_identifier:
issn:
- 0012-7094
publication_status: published
publisher: Duke University Press
publist_id: '4183'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Estimates on stochastic oscillatory integrals and on the heat kernel of the
magnetic Schrödinger operator
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 76
year: '1994'
...
---
_id: '11857'
abstract:
- lang: eng
text: Two edges e/sub 1/ and e/sub 2/ of an undirected graph are cycle-equivalent
iff all cycles that contain e/sub 1/ also contain e/sub 2/, i.e., iff e/sub 1/
and e/sub 2/ are a cut-edge pair. The cycle-equivalence classes of the control-flow
graph are used in optimizing compilers to speed up existing control-flow and data-flow
algorithms. While the cycle-equivalence classes can be computed in linear time,
we present the first fully dynamic algorithm for maintaining the cycle-equivalence
relation. In an n-node graph our data structure executes an edge insertion or
deletion in O(/spl radic/n log n) time and answers the query whether two given
edges are cycle-equivalent in O(log/sup 2/ n) time. We also present an algorithm
for plane graphs with O(log n) update and query time and for planar graphs with
O(log n) insertion time and O(log/sup 2/ n) query and deletion time. Additionally,
we show a lower bound of /spl Omega/(log n/log log n) for the amortized time per
operation for the dynamic cycle-equivalence problem in the cell probe model.<
>
article_processing_charge: No
author:
- first_name: Monika H
full_name: Henzinger, Monika H
id: 540c9bbd-f2de-11ec-812d-d04a5be85630
last_name: Henzinger
orcid: 0000-0002-5008-6530
citation:
ama: 'Henzinger MH. Fully dynamic cycle-equivalence in graphs. In: 35th Annual
Symposium on Foundations of Computer Science. Institute of Electrical and
Electronics Engineers; 1994:744-755. doi:10.1109/sfcs.1994.365718'
apa: 'Henzinger, M. H. (1994). Fully dynamic cycle-equivalence in graphs. In 35th
Annual Symposium on Foundations of Computer Science (pp. 744–755). Santa Fe,
NM, United States: Institute of Electrical and Electronics Engineers. https://doi.org/10.1109/sfcs.1994.365718'
chicago: Henzinger, Monika H. “Fully Dynamic Cycle-Equivalence in Graphs.” In 35th
Annual Symposium on Foundations of Computer Science, 744–55. Institute of
Electrical and Electronics Engineers, 1994. https://doi.org/10.1109/sfcs.1994.365718.
ieee: M. H. Henzinger, “Fully dynamic cycle-equivalence in graphs,” in 35th Annual
Symposium on Foundations of Computer Science, Santa Fe, NM, United States,
1994, pp. 744–755.
ista: 'Henzinger MH. 1994. Fully dynamic cycle-equivalence in graphs. 35th Annual
Symposium on Foundations of Computer Science. FOCS: Symposium on Foundations of
Computer Science, 744–755.'
mla: Henzinger, Monika H. “Fully Dynamic Cycle-Equivalence in Graphs.” 35th Annual
Symposium on Foundations of Computer Science, Institute of Electrical and
Electronics Engineers, 1994, pp. 744–55, doi:10.1109/sfcs.1994.365718.
short: M.H. Henzinger, in:, 35th Annual Symposium on Foundations of Computer Science,
Institute of Electrical and Electronics Engineers, 1994, pp. 744–755.
conference:
end_date: 1994-11-22
location: Santa Fe, NM, United States
name: 'FOCS: Symposium on Foundations of Computer Science'
start_date: 1994-11-20
date_created: 2022-08-16T08:29:08Z
date_published: 1994-11-01T00:00:00Z
date_updated: 2023-02-17T09:58:04Z
day: '01'
doi: 10.1109/sfcs.1994.365718
extern: '1'
language:
- iso: eng
month: '11'
oa_version: None
page: 744 - 755
publication: 35th Annual Symposium on Foundations of Computer Science
publication_identifier:
isbn:
- 0-8186-6580-7
publication_status: published
publisher: Institute of Electrical and Electronics Engineers
quality_controlled: '1'
scopus_import: '1'
status: public
title: Fully dynamic cycle-equivalence in graphs
type: conference
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '1994'
...
---
_id: '1947'
abstract:
- lang: eng
text: Mitochondrial transhydrogenase has been reported previously to be inhibited
by high, rather non-physiological concentrations (in the range of 2-20 mM) of
divalent cations. We show that the enzyme could be activated by low (from about
1 μM to 1 mM) concentrations of Ca2+ and Mg2+, which are within physiological
range. These results bring in line the effects observed with mitochondrial enzyme
to the findings with bacterial transhydrogenases. The activation of transhydrogenase
by divalent cations is interpreted as an increase in affinity of the NADP(H)-binding
site of the enzyme-NAD(H) complex. Reported effects of the metal ions could be
important for the enzyme function in vivo.
acknowledgement: 'This work was supported by a Wellcome Trust fellowship to L.A.S. '
article_processing_charge: No
article_type: original
author:
- first_name: Leonid A
full_name: Sazanov, Leonid A
id: 338D39FE-F248-11E8-B48F-1D18A9856A87
last_name: Sazanov
orcid: 0000-0002-0977-7989
- first_name: Julie
full_name: Jackson, Julie
last_name: Jackson
citation:
ama: Sazanov LA, Jackson J. Activation and inhibition of mitochondrial transhydrogenase
by metal ions. Biochimica et Biophysica Acta - Bioenergetics. 1993;1144(2):225-228.
doi:10.1016/0005-2728(93)90177-H
apa: Sazanov, L. A., & Jackson, J. (1993). Activation and inhibition of mitochondrial
transhydrogenase by metal ions. Biochimica et Biophysica Acta - Bioenergetics.
Elsevier. https://doi.org/10.1016/0005-2728(93)90177-H
chicago: Sazanov, Leonid A, and Julie Jackson. “Activation and Inhibition of Mitochondrial
Transhydrogenase by Metal Ions.” Biochimica et Biophysica Acta - Bioenergetics.
Elsevier, 1993. https://doi.org/10.1016/0005-2728(93)90177-H.
ieee: L. A. Sazanov and J. Jackson, “Activation and inhibition of mitochondrial
transhydrogenase by metal ions,” Biochimica et Biophysica Acta - Bioenergetics,
vol. 1144, no. 2. Elsevier, pp. 225–228, 1993.
ista: Sazanov LA, Jackson J. 1993. Activation and inhibition of mitochondrial transhydrogenase
by metal ions. Biochimica et Biophysica Acta - Bioenergetics. 1144(2), 225–228.
mla: Sazanov, Leonid A., and Julie Jackson. “Activation and Inhibition of Mitochondrial
Transhydrogenase by Metal Ions.” Biochimica et Biophysica Acta - Bioenergetics,
vol. 1144, no. 2, Elsevier, 1993, pp. 225–28, doi:10.1016/0005-2728(93)90177-H.
short: L.A. Sazanov, J. Jackson, Biochimica et Biophysica Acta - Bioenergetics 1144
(1993) 225–228.
date_created: 2018-12-11T11:54:52Z
date_published: 1993-09-13T00:00:00Z
date_updated: 2022-06-01T12:51:32Z
day: '13'
doi: 10.1016/0005-2728(93)90177-H
extern: '1'
external_id:
pmid:
- '8369341 '
intvolume: ' 1144'
issue: '2'
language:
- iso: eng
main_file_link:
- url: https://www.sciencedirect.com/science/article/pii/000527289390177H?via%3Dihub
month: '09'
oa_version: None
page: 225 - 228
pmid: 1
publication: Biochimica et Biophysica Acta - Bioenergetics
publication_identifier:
issn:
- 0005-2728
publication_status: published
publisher: Elsevier
publist_id: '5136'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Activation and inhibition of mitochondrial transhydrogenase by metal ions
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 1144
year: '1993'
...
---
_id: '1948'
acknowledgement: 'We acknowledge financial support from the Wellcome Trust (fellowship
to L.A.S) '
article_processing_charge: No
article_type: original
author:
- first_name: Leonid A
full_name: Sazanov, Leonid A
id: 338D39FE-F248-11E8-B48F-1D18A9856A87
last_name: Sazanov
orcid: 0000-0002-0977-7989
- first_name: Julie
full_name: Jackson, Julie
last_name: Jackson
citation:
ama: Sazanov LA, Jackson J. Possible functions of the NADP-linked isocitrate dehydrogenase
and H+ -transhydrogenase in heart mitochondria . Biochemical Society Transactions.
1993;21(3):260. doi:10.1042/bst021260s
apa: Sazanov, L. A., & Jackson, J. (1993). Possible functions of the NADP-linked
isocitrate dehydrogenase and H+ -transhydrogenase in heart mitochondria . Biochemical
Society Transactions. Portland Press. https://doi.org/10.1042/bst021260s
chicago: Sazanov, Leonid A, and Julie Jackson. “Possible Functions of the NADP-Linked
Isocitrate Dehydrogenase and H+ -Transhydrogenase in Heart Mitochondria .” Biochemical
Society Transactions. Portland Press, 1993. https://doi.org/10.1042/bst021260s.
ieee: L. A. Sazanov and J. Jackson, “Possible functions of the NADP-linked isocitrate
dehydrogenase and H+ -transhydrogenase in heart mitochondria ,” Biochemical
Society Transactions, vol. 21, no. 3. Portland Press, p. 260, 1993.
ista: Sazanov LA, Jackson J. 1993. Possible functions of the NADP-linked isocitrate
dehydrogenase and H+ -transhydrogenase in heart mitochondria . Biochemical Society
Transactions. 21(3), 260.
mla: Sazanov, Leonid A., and Julie Jackson. “Possible Functions of the NADP-Linked
Isocitrate Dehydrogenase and H+ -Transhydrogenase in Heart Mitochondria .” Biochemical
Society Transactions, vol. 21, no. 3, Portland Press, 1993, p. 260, doi:10.1042/bst021260s.
short: L.A. Sazanov, J. Jackson, Biochemical Society Transactions 21 (1993) 260.
date_created: 2018-12-11T11:54:52Z
date_published: 1993-01-01T00:00:00Z
date_updated: 2022-06-01T13:17:02Z
day: '01'
doi: 10.1042/bst021260s
extern: '1'
external_id:
pmid:
- '8224412 '
intvolume: ' 21'
issue: '3'
language:
- iso: eng
main_file_link:
- url: https://portlandpress.com/biochemsoctrans/article-abstract/21/3/260S/83260/Possible-functions-of-the-NADP-linked-isocitrate?redirectedFrom=fulltext
month: '01'
oa_version: None
page: '260'
pmid: 1
publication: Biochemical Society Transactions
publication_identifier:
issn:
- 0300-5127
publication_status: published
publisher: Portland Press
publist_id: '5137'
quality_controlled: '1'
scopus_import: '1'
status: public
title: 'Possible functions of the NADP-linked isocitrate dehydrogenase and H+ -transhydrogenase
in heart mitochondria '
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 21
year: '1993'
...
---
_id: '1950'
article_processing_charge: No
article_type: original
author:
- first_name: Julie
full_name: Jackson, Julie
last_name: Jackson
- first_name: N P J
full_name: Cotton, N P J
last_name: Cotton
- first_name: Ross
full_name: Williams, Ross
last_name: Williams
- first_name: Tania
full_name: Bizouarn, Tania
last_name: Bizouarn
- first_name: Mike
full_name: Hutton, Mike
last_name: Hutton
- first_name: Leonid A
full_name: Sazanov, Leonid A
id: 338D39FE-F248-11E8-B48F-1D18A9856A87
last_name: Sazanov
orcid: 0000-0002-0977-7989
- first_name: Christopher
full_name: Thomas, Christopher
last_name: Thomas
citation:
ama: Jackson J, Cotton NPJ, Williams R, et al. Proton-translocating transhydrogenase
in bacteria. Biochemical Society Transactions. 1993;21(4):1010-1013. doi:10.1042/bst0211010
apa: Jackson, J., Cotton, N. P. J., Williams, R., Bizouarn, T., Hutton, M., Sazanov,
L. A., & Thomas, C. (1993). Proton-translocating transhydrogenase in bacteria.
Biochemical Society Transactions. Portland Press. https://doi.org/10.1042/bst0211010
chicago: Jackson, Julie, N P J Cotton, Ross Williams, Tania Bizouarn, Mike Hutton,
Leonid A Sazanov, and Christopher Thomas. “Proton-Translocating Transhydrogenase
in Bacteria.” Biochemical Society Transactions. Portland Press, 1993. https://doi.org/10.1042/bst0211010.
ieee: J. Jackson et al., “Proton-translocating transhydrogenase in bacteria,”
Biochemical Society Transactions, vol. 21, no. 4. Portland Press, pp. 1010–1013,
1993.
ista: Jackson J, Cotton NPJ, Williams R, Bizouarn T, Hutton M, Sazanov LA, Thomas
C. 1993. Proton-translocating transhydrogenase in bacteria. Biochemical Society
Transactions. 21(4), 1010–1013.
mla: Jackson, Julie, et al. “Proton-Translocating Transhydrogenase in Bacteria.”
Biochemical Society Transactions, vol. 21, no. 4, Portland Press, 1993,
pp. 1010–13, doi:10.1042/bst0211010.
short: J. Jackson, N.P.J. Cotton, R. Williams, T. Bizouarn, M. Hutton, L.A. Sazanov,
C. Thomas, Biochemical Society Transactions 21 (1993) 1010–1013.
date_created: 2018-12-11T11:54:52Z
date_published: 1993-11-01T00:00:00Z
date_updated: 2022-06-01T12:16:19Z
day: '01'
doi: 10.1042/bst0211010
extern: '1'
external_id:
pmid:
- '8131888'
intvolume: ' 21'
issue: '4'
language:
- iso: eng
main_file_link:
- url: https://portlandpress.com/biochemsoctrans/article-abstract/21/4/1010/86733/Proton-translocating-transhydrogenase-in-bacteria?redirectedFrom=fulltext
month: '11'
oa_version: None
page: 1010 - 1013
pmid: 1
publication: Biochemical Society Transactions
publication_identifier:
issn:
- 0300-5127
publication_status: published
publisher: Portland Press
publist_id: '5135'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Proton-translocating transhydrogenase in bacteria
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 21
year: '1993'
...
---
_id: '3446'
abstract:
- lang: eng
text: An effective character recognition procedure implemented on a new type of
hardware system and using a new architecture called CNND is proposed. This CNND
contains one or more analog cellular neural networks (CNNs) and some digital logic,
combining the advantages of the fast analog CNN signal processing and the fast
and easy decision capability of digital logic. It is shown that the CNND system
can be used for recognition of multifont printed or handwritten characters and
could recognize 100,000 char/s with a recognition rate of more than 95%. The more
advantage of the system over competing types is that there is not an extra feature
extraction procedure implemented in slow hardware
article_processing_charge: No
article_type: original
author:
- first_name: Tamas
full_name: Sziranyi, Tamas
last_name: Sziranyi
- first_name: Jozsef L
full_name: Csicsvari, Jozsef L
id: 3FA14672-F248-11E8-B48F-1D18A9856A87
last_name: Csicsvari
orcid: 0000-0002-5193-4036
citation:
ama: 'Sziranyi T, Csicsvari JL. High-speed character recognition using a dual cellular
neural network architecture (CNND). IEEE Transactions on Circuits and Systems
II: Analog and Digital Signal Processing. 1993;40(3):223-231. doi:10.1109/82.222823'
apa: 'Sziranyi, T., & Csicsvari, J. L. (1993). High-speed character recognition
using a dual cellular neural network architecture (CNND). IEEE Transactions
on Circuits and Systems II: Analog and Digital Signal Processing. IEEE. https://doi.org/10.1109/82.222823'
chicago: 'Sziranyi, Tamas, and Jozsef L Csicsvari. “High-Speed Character Recognition
Using a Dual Cellular Neural Network Architecture (CNND).” IEEE Transactions
on Circuits and Systems II: Analog and Digital Signal Processing. IEEE, 1993.
https://doi.org/10.1109/82.222823.'
ieee: 'T. Sziranyi and J. L. Csicsvari, “High-speed character recognition using
a dual cellular neural network architecture (CNND),” IEEE Transactions on Circuits
and Systems II: Analog and Digital Signal Processing, vol. 40, no. 3. IEEE,
pp. 223–231, 1993.'
ista: 'Sziranyi T, Csicsvari JL. 1993. High-speed character recognition using a
dual cellular neural network architecture (CNND). IEEE Transactions on Circuits
and Systems II: Analog and Digital Signal Processing. 40(3), 223–231.'
mla: 'Sziranyi, Tamas, and Jozsef L. Csicsvari. “High-Speed Character Recognition
Using a Dual Cellular Neural Network Architecture (CNND).” IEEE Transactions
on Circuits and Systems II: Analog and Digital Signal Processing, vol. 40,
no. 3, IEEE, 1993, pp. 223–31, doi:10.1109/82.222823.'
short: 'T. Sziranyi, J.L. Csicsvari, IEEE Transactions on Circuits and Systems II:
Analog and Digital Signal Processing 40 (1993) 223–231.'
date_created: 2018-12-11T12:03:22Z
date_published: 1993-03-01T00:00:00Z
date_updated: 2022-03-30T14:44:44Z
day: '01'
doi: 10.1109/82.222823
extern: '1'
intvolume: ' 40'
issue: '3'
language:
- iso: eng
main_file_link:
- url: https://ieeexplore.ieee.org/document/222823
month: '03'
oa_version: None
page: 223 - 231
publication: 'IEEE Transactions on Circuits and Systems II: Analog and Digital Signal
Processing'
publication_identifier:
issn:
- 1057-7130
publication_status: published
publisher: IEEE
publist_id: '2941'
quality_controlled: '1'
scopus_import: '1'
status: public
title: High-speed character recognition using a dual cellular neural network architecture
(CNND)
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 40
year: '1993'
...
---
_id: '3451'
acknowledgement: I thank Prof. B. Sakmann for generous support and Drs. M. Häusser
and A. Villarroel for critically reading the manuscript.
alternative_title:
- 'Annals of the New York Academy of Sciences '
article_processing_charge: No
author:
- first_name: Peter M
full_name: Jonas, Peter M
id: 353C1B58-F248-11E8-B48F-1D18A9856A87
last_name: Jonas
orcid: 0000-0001-5001-4804
citation:
ama: 'Jonas PM. Glutamate receptors in the central nervous system. In: Molecular
Basis of Ion Channels and Receptors Involved in Nerve Excitation, Synaptic Transmission,
and Muscle Contraction. Vol 707. Annals of the New York Academy of Sciences.
New York Academy of Sciences; 1993:126-135. doi:10.1111/j.1749-6632.1993.tb38048.x'
apa: Jonas, P. M. (1993). Glutamate receptors in the central nervous system. In
Molecular Basis of Ion Channels and Receptors Involved in Nerve Excitation,
Synaptic Transmission, and Muscle Contraction (Vol. 707, pp. 126–135). New
York Academy of Sciences. https://doi.org/10.1111/j.1749-6632.1993.tb38048.x
chicago: Jonas, Peter M. “Glutamate Receptors in the Central Nervous System.” In
Molecular Basis of Ion Channels and Receptors Involved in Nerve Excitation,
Synaptic Transmission, and Muscle Contraction, 707:126–35. Annals of the New
York Academy of Sciences. New York Academy of Sciences, 1993. https://doi.org/10.1111/j.1749-6632.1993.tb38048.x.
ieee: P. M. Jonas, “Glutamate receptors in the central nervous system,” in Molecular
Basis of Ion Channels and Receptors Involved in Nerve Excitation, Synaptic Transmission,
and Muscle Contraction, vol. 707, New York Academy of Sciences, 1993, pp.
126–135.
ista: 'Jonas PM. 1993.Glutamate receptors in the central nervous system. In: Molecular
Basis of Ion Channels and Receptors Involved in Nerve Excitation, Synaptic Transmission,
and Muscle Contraction. Annals of the New York Academy of Sciences , vol. 707,
126–135.'
mla: Jonas, Peter M. “Glutamate Receptors in the Central Nervous System.” Molecular
Basis of Ion Channels and Receptors Involved in Nerve Excitation, Synaptic Transmission,
and Muscle Contraction, vol. 707, New York Academy of Sciences, 1993, pp.
126–35, doi:10.1111/j.1749-6632.1993.tb38048.x.
short: P.M. Jonas, in:, Molecular Basis of Ion Channels and Receptors Involved in
Nerve Excitation, Synaptic Transmission, and Muscle Contraction, New York Academy
of Sciences, 1993, pp. 126–135.
date_created: 2018-12-11T12:03:24Z
date_published: 1993-12-20T00:00:00Z
date_updated: 2022-03-30T12:35:23Z
day: '20'
doi: 10.1111/j.1749-6632.1993.tb38048.x
extern: '1'
external_id:
pmid:
- '9729204'
intvolume: ' 707'
language:
- iso: eng
main_file_link:
- url: https://nyaspubs.onlinelibrary.wiley.com/doi/10.1111/j.1749-6632.1993.tb38048.x
month: '12'
oa_version: None
page: 126 - 135
pmid: 1
publication: Molecular Basis of Ion Channels and Receptors Involved in Nerve Excitation,
Synaptic Transmission, and Muscle Contraction
publication_status: published
publisher: New York Academy of Sciences
publist_id: '2936'
quality_controlled: '1'
scopus_import: '1'
series_title: Annals of the New York Academy of Sciences
status: public
title: Glutamate receptors in the central nervous system
type: book_chapter
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 707
year: '1993'
...
---
_id: '3452'
abstract:
- lang: eng
text: In recent years, considerable progress in our understanding of the molecular
events underlying excitatory synaptic transmission has been made. This progress
was mainly achieved by technical advances, among them the patch-clamp technique
in brain slices (Edwards et al., 1989), fast application of agonists (Franke et
al., 1987), and cloning and functional expression of GluR channels of the nonNMDA
type (e.g., Hollmann et al., 1989). A suitable model for studying excitatory postsynaptic
currents (EPSCs) in the brain slice with patch-clamp techniques is the mossy fiber
synapse on CA3 pyramidal cells of rat hippocampus (MF-CA3 synapse). This synapse
is located close to the cell soma and should provide almost ideal space-clamp
conditions. A comparison of MF-CA3 EPSCs with the currents activated by fast application
of glutamate on membrane patches isolated from CA3 cell somata suggests that the
concentration of glutamate in the synaptic cleft during excitatory synaptic transmission
is high (about 1 mM) and that the transmitter remains in the synaptic cleft only
briefly (about 1 ms). It seems likely that desensitization influences the peak
amplitude of the EPSC in several ways. Brief pulses of glutamate cause desensitization,
from which the glutamate receptor channels recover only slowly, and micromolar
ambient glutamate concentrations produce desensitization at equilibrium. From
the functional properties of recombinant GluR channels, in situ hybridization
data, and patch-clamp experiments on different neuronal and nonneuronal cell types,
a picture of the molecular identity of native channels emerges. In neurons of
the hippocampus the pharmacological features of these channels were similar to
recombinant channels assembled from subunits of the AMPA/kainate subtype which
are strongly expressed in these cells. The native channels are characterized by
outward rectification of the steady-state I-V and low Ca permeability, similar
to recombinant channels containing the GluR-B subunit. This is consistent with
the ubiquitous expression of this subunit in hippocampal neurones. In contrast,
GluR channels from cerebellar glial cells, which uniquely in the central nervous
system lack the expression of GluR-B subunits, show double rectification and high
Ca permeability. The results suggest that the native functional nonNMDA glutamate
receptor channels in the CNS are assembled form subunits of the AMPA/kainate subtype
in a cell-specific way, with the functional properties of GluR channels in neurones
being dominated by the GluR-B subunit.
alternative_title:
- EXS
article_processing_charge: No
author:
- first_name: Peter M
full_name: Jonas, Peter M
id: 353C1B58-F248-11E8-B48F-1D18A9856A87
last_name: Jonas
orcid: 0000-0001-5001-4804
citation:
ama: 'Jonas PM. AMPA-type glutamate receptors - nonselective cation channels mediating
fast excitatory transmission in the CNS. In: Siemen D, ed. Nonselective Cation
Channels: Pharmacology, Physiology and Biophysics. Vol 66. Birkhäuser; 1993:61-76.
doi:10.1007/978-3-0348-7327-7_4'
apa: 'Jonas, P. M. (1993). AMPA-type glutamate receptors - nonselective cation channels
mediating fast excitatory transmission in the CNS. In D. Siemen (Ed.), Nonselective
cation channels: Pharmacology, Physiology and Biophysics. (Vol. 66, pp. 61–76).
Birkhäuser. https://doi.org/10.1007/978-3-0348-7327-7_4'
chicago: 'Jonas, Peter M. “AMPA-Type Glutamate Receptors - Nonselective Cation Channels
Mediating Fast Excitatory Transmission in the CNS.” In Nonselective Cation
Channels: Pharmacology, Physiology and Biophysics., edited by Detlef Siemen,
66:61–76. Birkhäuser, 1993. https://doi.org/10.1007/978-3-0348-7327-7_4.'
ieee: 'P. M. Jonas, “AMPA-type glutamate receptors - nonselective cation channels
mediating fast excitatory transmission in the CNS,” in Nonselective cation
channels: Pharmacology, Physiology and Biophysics., vol. 66, D. Siemen, Ed.
Birkhäuser, 1993, pp. 61–76.'
ista: 'Jonas PM. 1993.AMPA-type glutamate receptors - nonselective cation channels
mediating fast excitatory transmission in the CNS. In: Nonselective cation channels:
Pharmacology, Physiology and Biophysics. EXS, vol. 66, 61–76.'
mla: 'Jonas, Peter M. “AMPA-Type Glutamate Receptors - Nonselective Cation Channels
Mediating Fast Excitatory Transmission in the CNS.” Nonselective Cation Channels:
Pharmacology, Physiology and Biophysics., edited by Detlef Siemen, vol. 66,
Birkhäuser, 1993, pp. 61–76, doi:10.1007/978-3-0348-7327-7_4.'
short: 'P.M. Jonas, in:, D. Siemen (Ed.), Nonselective Cation Channels: Pharmacology,
Physiology and Biophysics., Birkhäuser, 1993, pp. 61–76.'
date_created: 2018-12-11T12:03:24Z
date_published: 1993-01-01T00:00:00Z
date_updated: 2022-03-30T11:46:44Z
day: '01'
doi: 10.1007/978-3-0348-7327-7_4
editor:
- first_name: Detlef
full_name: Siemen, Detlef
last_name: Siemen
extern: '1'
external_id:
pmid:
- '7505664'
intvolume: ' 66'
language:
- iso: eng
main_file_link:
- url: https://link.springer.com/chapter/10.1007/978-3-0348-7327-7_4
month: '01'
oa_version: None
page: 61 - 76
pmid: 1
publication: 'Nonselective cation channels: Pharmacology, Physiology and Biophysics.'
publication_identifier:
isbn:
- 978-3-0348-7327-7
publication_status: published
publisher: Birkhäuser
publist_id: '2935'
quality_controlled: '1'
scopus_import: '1'
status: public
title: AMPA-type glutamate receptors - nonselective cation channels mediating fast
excitatory transmission in the CNS
type: book_chapter
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 66
year: '1993'
...
---
_id: '3473'
abstract:
- lang: eng
text: Sixteen different K+ channel subtypes have been cloned from mammalian tissue.
Considering their sequence homology to Drosophila Shaker, Shab, Shaw and Shal
channels, they were classified into four corresponding classes Kv1-4. All K+ channels
belonging to these classes consist of four subunits with each six hydrophobic
segments (S1-S6) and a characteristic structure-function relationship of certain
domains in their amino acid sequence. These domains are, the inactivation gate
in the N-terminal region of the sequence, the voltage sensor in the fourth hydrophobic
segment (S4), and the pore-region in the H5 segment between S5 and S6. In some
functional properties K+ channels cloned from the mammalian brain, however, differ
from Drosophila K+ channels. These are pharmacological differences, differences
in the threshold of activation and in regulation of inactivation. Part of these
differences are important to understand their physiological role in the brain.
Based on their functional characteristics the expression pattern of cloned K+
channels in the rat brain can be correlated with the properties of K+ currents
measured in central neurones.
article_processing_charge: No
article_type: original
author:
- first_name: Peter
full_name: Ruppersberg, Peter
last_name: Ruppersberg
- first_name: Mamfred
full_name: Ermler, Mamfred
last_name: Ermler
- first_name: Martin
full_name: Knopf, Martin
last_name: Knopf
- first_name: Wilfried
full_name: Kues, Wilfried
last_name: Kues
- first_name: Peter M
full_name: Jonas, Peter M
id: 353C1B58-F248-11E8-B48F-1D18A9856A87
last_name: Jonas
orcid: 0000-0001-5001-4804
- first_name: Michael
full_name: Koenen, Michael
last_name: Koenen
citation:
ama: Ruppersberg P, Ermler M, Knopf M, Kues W, Jonas PM, Koenen M. Properties of
Shaker-homologous potassium channels expressed in the mammalian brain. Cellular
Physiology and Biochemistry. 1993;3:250-269. doi:10.1159/000154691
apa: Ruppersberg, P., Ermler, M., Knopf, M., Kues, W., Jonas, P. M., & Koenen,
M. (1993). Properties of Shaker-homologous potassium channels expressed in the
mammalian brain. Cellular Physiology and Biochemistry. S. Karger AG. https://doi.org/10.1159/000154691
chicago: Ruppersberg, Peter, Mamfred Ermler, Martin Knopf, Wilfried Kues, Peter
M Jonas, and Michael Koenen. “Properties of Shaker-Homologous Potassium Channels
Expressed in the Mammalian Brain.” Cellular Physiology and Biochemistry.
S. Karger AG, 1993. https://doi.org/10.1159/000154691.
ieee: P. Ruppersberg, M. Ermler, M. Knopf, W. Kues, P. M. Jonas, and M. Koenen,
“Properties of Shaker-homologous potassium channels expressed in the mammalian
brain.,” Cellular Physiology and Biochemistry, vol. 3. S. Karger AG, pp.
250–269, 1993.
ista: Ruppersberg P, Ermler M, Knopf M, Kues W, Jonas PM, Koenen M. 1993. Properties
of Shaker-homologous potassium channels expressed in the mammalian brain. Cellular
Physiology and Biochemistry. 3, 250–269.
mla: Ruppersberg, Peter, et al. “Properties of Shaker-Homologous Potassium Channels
Expressed in the Mammalian Brain.” Cellular Physiology and Biochemistry,
vol. 3, S. Karger AG, 1993, pp. 250–69, doi:10.1159/000154691.
short: P. Ruppersberg, M. Ermler, M. Knopf, W. Kues, P.M. Jonas, M. Koenen, Cellular
Physiology and Biochemistry 3 (1993) 250–269.
date_created: 2018-12-11T12:03:31Z
date_published: 1993-01-01T00:00:00Z
date_updated: 2022-03-30T10:21:04Z
day: '01'
doi: 10.1159/000154691
extern: '1'
intvolume: ' 3'
language:
- iso: eng
main_file_link:
- url: https://www.karger.com/Article/Abstract/154691
month: '01'
oa_version: None
page: 250 - 269
publication: Cellular Physiology and Biochemistry
publication_identifier:
issn:
- 1015-8987
publication_status: published
publisher: S. Karger AG
publist_id: '2914'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Properties of Shaker-homologous potassium channels expressed in the mammalian
brain.
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 3
year: '1993'
...
---
_id: '3474'
abstract:
- lang: eng
text: 1. Excitatory postsynaptic currents (EPSCs) were recorded in CA3 pyramidal
cells of hippocampal slices of 15- to 24-day-old rats (22 degrees C) using the
whole-cell configuration of the patch clamp technique. 2. Composite EPSCs were
evoked by extracellular stimulation of the mossy fibre tract. Using the selective
blockers 6-cyano-7-nitroquinoxaline-2,3-dione (CNQX) and D-2-amino-5-phosphonopentanoic
acid (APV), a major alpha-amino-3-hydroxy-5-methylisoxazole-4-propionate (AMPA)/kainate
receptor-mediated component and a minor NMDA receptor-mediated component with
slower time course were distinguished. For the AMPA/kainate receptor-mediated
component, the peak current-voltage (I-V) relation was linear, with a reversal
potential close to 0 mV. The half-maximal blocking concentration of CNQX was 353
nM. 3. Unitary EPSCs of the mossy fibre terminal (MF)-CA3 pyramidal cell synapse
were evoked at membrane potentials of -70 to -90 mV by low-intensity extracellular
stimulation of granule cell somata using fine-tipped pipettes. The EPSC peak amplitude
as a function of stimulus intensity showed all-or-none behaviour. The region of
low threshold was restricted to a few micrometres. This suggests that extracellular
stimulation was focal, and that the stimulus-evoked EPSCs were unitary. 4. Latency
and rise time histograms of EPSCs evoked by granule cell stimulation showed narrow
unimodal distributions within each experiment. The mean latency was 4.2 +/- 1.0
ms, and the mean 20-80% rise time was 0.6 +/- 0.1 ms (23 cells). When fitted within
the range 0.7 ms to 20 ms after the peak, the decay of the EPSCs with the fastest
rise (rise time 0.5 ms or less) could be described by a single exponential function;
the mean time constant was in the range 3.0-6.6 ms with a mean of 4.8 ms (8 cells).
5. Peak amplitudes of the EPSCs evoked by suprathreshold granule cell stimulation
fluctuated between trials. The apparent EPSC peak conductance in normal extracellular
solution (2 mM Ca2+, 1 mM Mg2+), excluding failures, was 1 nS. Reducing the Ca2+
concentration and increasing the Mg2+ concentration reduced the mean peak amplitude
in a concentration-dependent manner. 6. Peaks in EPSC peak amplitude distributions
were apparent in low Ca2+ and high Mg2+. Using the criteria of equidistance and
the presence of peaks and dips in the autocorrelation function, five of nine EPSC
peak amplitude distributions were judged to be quantal.
acknowledgement: "We are indebted to Professor B. Katz for critically reading the
manuscript and for helpful suggestions. We especially thank Professor D. Colquhoun
for several discussions, for generously providing the source codes of programs for
maximum-likelihood fit with sums of Gaussian functions, a routine for calculating
the error function and for critically reading the manuscript. We also thank Drs
A. Larkman, P. Ruppersberg, N. Spuston and G. Stuart for critically reading the
manuscript, P. Andersen, B. Betz, J. Evans, K. Harris, E. v. Kitzing, R. Rahamimov
and K. Stratford for helpful discussions, and J. J. B. Jack for much-needed advice
and guidance to G.M. We thank K. Bauer, F. Helmchen, M. Huke, B. Manz and especially
A. Roth for computer programming, B. Werner for typing the manuscript, and M. Kaiser
for excellent technical assistance. Part of the project was supported by the Deutsche
Forschungsgemeinschaft (SFB-317)\r\nand the Wellcome Trust."
article_processing_charge: No
article_type: original
author:
- first_name: Peter M
full_name: Jonas, Peter M
id: 353C1B58-F248-11E8-B48F-1D18A9856A87
last_name: Jonas
orcid: 0000-0001-5001-4804
- first_name: Guy
full_name: Major, Guy
last_name: Major
- first_name: Bert
full_name: Sakmann, Bert
last_name: Sakmann
citation:
ama: Jonas PM, Major G, Sakmann B. Quantal components of unitary EPSCs at the mossy
fibre synapse on CA3 pyramidal cells of rat hippocampus. Journal of Physiology.
1993;472:615-663. doi:10.1113/jphysiol.1993.sp019965
apa: Jonas, P. M., Major, G., & Sakmann, B. (1993). Quantal components of unitary
EPSCs at the mossy fibre synapse on CA3 pyramidal cells of rat hippocampus. Journal
of Physiology. Wiley-Blackwell. https://doi.org/10.1113/jphysiol.1993.sp019965
chicago: Jonas, Peter M, Guy Major, and Bert Sakmann. “Quantal Components of Unitary
EPSCs at the Mossy Fibre Synapse on CA3 Pyramidal Cells of Rat Hippocampus.” Journal
of Physiology. Wiley-Blackwell, 1993. https://doi.org/10.1113/jphysiol.1993.sp019965.
ieee: P. M. Jonas, G. Major, and B. Sakmann, “Quantal components of unitary EPSCs
at the mossy fibre synapse on CA3 pyramidal cells of rat hippocampus,” Journal
of Physiology, vol. 472. Wiley-Blackwell, pp. 615–663, 1993.
ista: Jonas PM, Major G, Sakmann B. 1993. Quantal components of unitary EPSCs at
the mossy fibre synapse on CA3 pyramidal cells of rat hippocampus. Journal of
Physiology. 472, 615–663.
mla: Jonas, Peter M., et al. “Quantal Components of Unitary EPSCs at the Mossy Fibre
Synapse on CA3 Pyramidal Cells of Rat Hippocampus.” Journal of Physiology,
vol. 472, Wiley-Blackwell, 1993, pp. 615–63, doi:10.1113/jphysiol.1993.sp019965.
short: P.M. Jonas, G. Major, B. Sakmann, Journal of Physiology 472 (1993) 615–663.
date_created: 2018-12-11T12:03:31Z
date_published: 1993-12-01T00:00:00Z
date_updated: 2022-03-30T09:33:19Z
day: '01'
doi: 10.1113/jphysiol.1993.sp019965
extern: '1'
external_id:
pmid:
- '7908327'
intvolume: ' 472'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1160505
month: '12'
oa: 1
oa_version: Published Version
page: 615 - 663
pmid: 1
publication: Journal of Physiology
publication_identifier:
issn:
- 0022-3751
publication_status: published
publisher: Wiley-Blackwell
publist_id: '2913'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Quantal components of unitary EPSCs at the mossy fibre synapse on CA3 pyramidal
cells of rat hippocampus
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 472
year: '1993'
...
---
_id: '3568'
article_processing_charge: No
author:
- first_name: Herbert
full_name: Edelsbrunner, Herbert
id: 3FB178DA-F248-11E8-B48F-1D18A9856A87
last_name: Edelsbrunner
orcid: 0000-0002-9823-6833
citation:
ama: 'Edelsbrunner H. Geometric algorithms. In: Handbook of Convex Geometry.
North Holland; 1993:699-735. doi:10.1016/C2009-0-15705-7'
apa: Edelsbrunner, H. (1993). Geometric algorithms. In Handbook of Convex Geometry
(pp. 699–735). North Holland. https://doi.org/10.1016/C2009-0-15705-7
chicago: Edelsbrunner, Herbert. “Geometric Algorithms.” In Handbook of Convex
Geometry, 699–735. North Holland, 1993. https://doi.org/10.1016/C2009-0-15705-7.
ieee: H. Edelsbrunner, “Geometric algorithms,” in Handbook of Convex Geometry,
North Holland, 1993, pp. 699–735.
ista: 'Edelsbrunner H. 1993.Geometric algorithms. In: Handbook of Convex Geometry.
, 699–735.'
mla: Edelsbrunner, Herbert. “Geometric Algorithms.” Handbook of Convex Geometry,
North Holland, 1993, pp. 699–735, doi:10.1016/C2009-0-15705-7.
short: H. Edelsbrunner, in:, Handbook of Convex Geometry, North Holland, 1993, pp.
699–735.
date_created: 2018-12-11T12:04:00Z
date_published: 1993-08-24T00:00:00Z
date_updated: 2022-03-30T09:30:11Z
day: '24'
doi: 10.1016/C2009-0-15705-7
extern: '1'
language:
- iso: eng
main_file_link:
- url: https://www.sciencedirect.com/book/9780444895967/handbook-of-convex-geometry
month: '08'
oa_version: None
page: 699 - 735
publication: Handbook of Convex Geometry
publication_identifier:
isbn:
- 978-0-444-89596-7
publication_status: published
publisher: North Holland
publist_id: '2817'
status: public
title: Geometric algorithms
type: book_chapter
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
year: '1993'
...